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Relevant bibliographies by topics / Cellular Migration / Dissertations / Theses

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Dissertations / Theses on the topic 'Cellular Migration'

Author: Grafiati

Published: 4 June 2021

Last updated: 16 November 2024

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1

Dimchev, Georgi Aleksandrov. "Cellular regulators of myoblast migration and myogenesis." Thesis, Manchester Metropolitan University, 2012. http://e-space.mmu.ac.uk/315695/.

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Migration of myogenic cells is an important step in myogenesis and skeletal muscle repair. Migration is required for the cells to reach the site of damage, for their alignment and subsequent fusion. Limited migration is also one of the limitations of proposed therapies of diseases, such as Duchenne Muscular Dystrophy (DMD). Therefore, revealing the regulators of myogenic cell migration is important for improving our knowledge of myogenesis, but could also be applied in therapies for conditions, associated with loss of muscle mass and muscle weakness. In this thesis, extracellular and intracell

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2

Corvaglia, Valentina. "pna - assisted cellular migration on patterned surfaces." Doctoral thesis, Università degli studi di Trieste, 2013. http://hdl.handle.net/10077/8646.

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2011/2012<br>ABSTRACT - The ability to control the cellular microenvironment, such as cell-substrate and cell-cell interactions at the micro- and nanoscale, is important for advances in several fields such as medicine and immunology, biochemistry, biomaterials, and tissue engineering. In order to undergo fundamental biological processes, most mammalian cells must adhere to the underlying extracellular matrix (ECM), eliciting cell adhesion and migration processes that are critical to embryogenesis, angiogenesis, wound healing, tissue repair, and immunity response, to cite few. For instance, upo

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3

Hennig, Katharina. "Dynamique des forces motiles et brisure de symétrie chez la cellule migrante." Thesis, Université Grenoble Alpes (ComUE), 2018. http://www.theses.fr/2018GREAY040/document.

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La motilité cellulaire directionnelle au cours du développement de l'organisme et des tissus, l'homéostasie et la maladie nécessite une rupture de symétrie. Ce processus repose sur la capacité des cellules individuelles à établir une polarité avant-arrière, et peut se produire en l'absence de signaux externes. L'initiation de la migration a été attribuée à la polarisation spontanée des composants du cytosquelette, tandis que l'évolution spatio-temporelle des forces du cytosquelette résultant de l'interaction mécanique cellule-substrat continue n'a pas encore été résolue. Ici, nous établissons

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4

English, Jane Louise. "Cellular regulation of matrix metalloproteinase function." Thesis, University of East Anglia, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.247107.

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5

Ashrafzadeh, Parham. "Exploring Cellular Dynamics : From Vesicle Tethering to Cell Migration." Doctoral thesis, Uppsala universitet, Institutionen för medicinsk cellbiologi, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-306174.

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Cells in the body communicate with each other in order to cooperate efficiently. This communication is in part achieved by regulated secretion of signaling molecules, which when released from a cell may activate receptors present at the plasma membrane of an adjacent cell. Such signals affect both cell fate and behavior. Dysregulated signaling may lead to disease, including cancer. This thesis is focused on how exocytosis and subsequent activation and trafficking of receptors can be regulated, and what the consequences of this regulation may be for cell migration. Actin filaments are important

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6

Rodriguez, Marbelys. "Two Adaptation Mechanisms Regulate Cellular Migration in Dictyostelium discouideum." FIU Digital Commons, 2014. http://digitalcommons.fiu.edu/etd/1144.

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Dictyostelium discoideum is a simple model widely used to study many cellular functions, including differentiation, gene regulation, cellular trafficking and directional migration. Adaptation mechanisms are essential in the regulation of these cellular processes. The misregulation of adaptation components often results in persistent activation of signaling pathways and aberrant cellular responses. Studying adaptation mechanisms regulating cellular migration will be crucial in the treatment of many pathological conditions in which motility plays a central role, such as tumor metastasis and acut

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7

Petrolli, Vanni. "Confinement induced transition between wave-like cellular migration modes." Thesis, Université Grenoble Alpes (ComUE), 2019. http://www.theses.fr/2019GREAY056.

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La capacité des cellules à générer spontanément de l'ordre a l’échelle supra cellulaire repose sur l'interaction de signaux mécaniques et biochimiques. Si le consensus général est que la signalisation chimique est le régulateur principal du comportement cellulaire, il est aujourd’hui bien établi que l'impact des facteurs mécaniques est primordial sur des processus fondamentaux de la physiologie cellulaire tel que la différenciation, la prolifération, la motilité et qu’une dérégulation des paramètres mécaniques du microenvironnement des cellules sont impliqués dans un grand nombre de pathologie

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8

da, Silva Barbara Luisa. "Glioblastoma cell behaviour : a study of chemically-induced cellular connectivity and 3D modelling of cellular migration." Thesis, University of Leeds, 2018. http://etheses.whiterose.ac.uk/22479/.

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Glioblastoma multiforme (GBM) is the most common and deadliest brain cancer in adults. Despite considerable efforts at both bench and bedside, the average survival for GBM patients is only 14-15 months. This dismal prognosis stems from challenges in treatment and a malignant tumour biology. A key need in addressing GBM is to better understand and therapeutically target GBM cell invasion into the surrounding healthy brain tissue. Cytoskeletal remodelling and dynamics, mediated by ROCK effector proteins, play an important role in the ability of GBM cells to migrate. ROCK inhibition is being cons

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9

Kumar, Arun. "Cellular and molecular mechanism controlling collective glial cell migration in drosophila." Thesis, Strasbourg, 2013. http://www.theses.fr/2013STRAJ071/document.

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Le bon fonctionnement des réseaux neuronaux dépend des interactions entre les neurones et les cellules gliales. Alors que de nombreux efforts ont été faits pour comprendre les interactions entre les neurones, moins est connu sur la nature des interactions entre les cellules gliales ; ceci est due à la complexité du système nerveux des vertébrés, qui comprend plus de cellules gliales que de neurones. Cependant, le système nerveux de la drosophile à un rapport neurones-cellules gliales faible, ce qui fait de cet animal simple un modèle idéal pour évaluer ce concept. J’ai utilisé des approches gé

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10

Myer, Nicole M. "CLASP1 Regulated Endothelial Cell Branching Morphology and Directed Migration." Thesis, University of the Sciences in Philadelphia, 2017. http://pqdtopen.proquest.com/#viewpdf?dispub=10631484.

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<p> The eukaryotic cytoskeleton is composed of varying proteinaceous filaments and is responsible for intracellular transport, cell proliferation, cell morphogenesis, and cell motility. Microtubules are one of three cytoskeletal components and have a unique polymer structure. The hollow cylinders undergo rapid polymerization and depolymerization events (<i>i.e.</i> dynamic instability) to promote assembly at the leading edge of the cell and disassembly in the rear of the cell to drive the cell front forward and facilitate directional migration. High-resolution light microscopy and automated tr

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11

Long, Jennifer A. "Hormonal and Cellular Mechanisms of Fattening in Migratory Songbirds." Fogler Library, University of Maine, 2007. http://www.library.umaine.edu/theses/pdf/LongJA2007.pdf.

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12

Werner, Maria. "Studies of Cellular Regulatory Mechanisms : from Genetic Switches to Cell Migration." Doctoral thesis, KTH, Beräkningsbiologi, CB, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-12096.

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Cellular behaviour depends ultimately on the transcription of genes. If we know how transcription is controlled we have a better chance of understanding cellular processes. This thesis presents six studies, all concerning cellular regulatory mechanisms. One study is purely experimental and five are computational studies. A large part of the research concerns the Epstein-Barr virus (EBV). We investigate the latency programme switching of EBV, with an equilibrium statistical mechanics model that describes the transcription activities of two central viral promoters. We demonstrate that this syste

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13

Berzsenyi, Sara. "Cellular and molecular control of collective glial cell migration in drosophilia." Strasbourg, 2010. http://www.theses.fr/2010STRA6292.

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Une caractéristique fondamentale de nombreux types de cellules dans le corps, c'est leur capacité à se déplacer. L'aile de la drosophile en développement fournit un excellent modèle pour suivre le comportement de la migration des cellules gliales en chaînes in vitro et in vivo par microscopie time-lapse. Les cellules gliales sont organisées d'une manière tête-à-queue et se déplacent le long des axones. Avec la technique «UV-ablation», j’ai démontré que les cellules pionnières au début de la chaîne sont nécessaires pour la migration de la chaîne avant qu’elles commencent à bouger. Par l'ablatio

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Barbier, Lucie. "Study of cellular mechanisms allowing dendritic cell migration in restricted spaces." Thesis, université Paris-Saclay, 2020. http://www.theses.fr/2020UPASL028.

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En cas d'infection, les cellules dendritiques matures (CDm) migrent des tissus périphériques vers les ganglions lymphatiques où ils déclenchent la réponse immunitaire adaptative. Ce déplacement impose une série de contraintes physiques sur les CDm. Au niveau cellulaire, la migration des CDm repose sur la contractilité du cytosquelette d’actine et de myosine. Toutefois, la réponse mécanique spécifique qui permet aux CDm d'adapter leur mode de migration aux contraintes physiques n'a pas été entièrement caractérisée. Dans ce travail, nous avons combiné une série d'approches, des outils microfluid

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Rebman, Jane K. "Cellular and Molecular Mechanisms of Collective Migration in Facial Branchiomotor Neurons." VCU Scholars Compass, 2019. https://scholarscompass.vcu.edu/etd/5985.

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The directed migration of neurons is influenced by multiple guidance cues, that may include soluble attractive chemotactic factors and cell-cell contact mediated collective migration. The nature of these neuron-neuron interactions and their integration with chemotaxis remains unclear. Contact inhibition of locomotion (CIL), a process whereby cells undergoing a collision cease their migration towards the colliding cell, has been identified as a driving force behind the collective migration of several cell populations in vivo, but has not been described for neurons in the central nervous system.

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16

Molina, Delgado Angie. "Role of the microtubule-associated protein ATIP3 in cell migration and breast cancer metastasis." Phd thesis, Université René Descartes - Paris V, 2014. http://tel.archives-ouvertes.fr/tel-01068663.

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Breast cancer is the most common malignancy in women, affecting one out of eight women worldwide. Even if most of the breast tumors are efficiently treated using targeted therapies, there is still a heterogeneous breast cancer subpopulation known as "triple-negative", which is highly metastatic and, due to the absence of targeted therapies, of poor prognosis. The elucidation of the processes involved in tumor progression and metastasis remains an important challenge in the search for new therapies against this subtype of breast cancer. Previous results from the laboratory have shown that ATIP3

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Sailland, Juliette. "Régulation de la migration cellulaire par ERRα". Thesis, Lyon, École normale supérieure, 2012. http://www.theses.fr/2012ENSL0792.

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Le récepteur ERRα (Estrogen Receptor-Related Receptor alpha) appartient à la superfamille des récepteurs nucléaires. Une forte expression de ERRα est corrélée à un mauvais pronostic, suggérant l’implication de ce récepteur dans le processus métastatique. Mon projet est d'analyser le rôle de ERRα dans les mouvements cellulaires. J’ai montré qu’inhiber ERRα perturbe la migration cellulaire. L’étude des mouvements montre que l’absence de ERRα induit une perturbation de l’orientation cellulaire, du nombre des fibres de stress et des protrusions membranaires. Les cellules migrent de façon désorient

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18

Jones, Patrick. "CAMSAP2 and CAMSAP3 Alter MT Dynamics and Promote Cellular Migration in Polarized HUVECs." Thesis, University of the Sciences in Philadelphia, 2016. http://pqdtopen.proquest.com/#viewpdf?dispub=10294819.

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<p> Angiogenesis, the formation of new blood vessels, requires the reorganization of microtubules (MT), which are polar cytoskeletal structures, consisting of a free-plus end and a minus-end that is free or anchored. CAMSAP2 and CAMSAP3 have been shown to bind and stabilize MT minus-ends; yet, this activity's contribution to MT organization and directional migration is unknown. To investigate this contribution, we performed live-cell imaging of polarized HUVECs expressing CAMSAP2 or CAMSAP3. Our results show that CAMSAP2 and CAMSAP3 localized to the trailing edge

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19

Bawazir, Nada Sami. "Tuning of Plasma Membrane PI(4,5)P2 Charge Regulates Cell Migration and Glycolysis." Thesis, University of the Sciences in Philadelphia, 2020. http://pqdtopen.proquest.com/#viewpdf?dispub=27666361.

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Directional cell migration, chemotaxis, requires a polarized cell morphology in which the cell extends pseudopodia at the front and contracts the rear to move towards a stimulus. PI(4,5)P2 levels set up a threshold for the activity of signaling molecules at the rear and the leading-edge of a cell. To further demonstrate the importance of plasma membrane (PM) PI(4,5)P2 in maintaining cell morphology during chemotaxis, we used a mutant strain of the eukaryotic model system, Dictyostelium discoideum. This mutant strain lacks the type I PIP5 kinase, which is the main enzyme synthesizing PI(4,5)P2.

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20

Zhang, Congyingzi. "Morphological study of cell protrusions during redirected migration in human fibroblast cells." Bowling Green State University / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1367724529.

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21

Chu, Calvin School of Biomedical Engineering UNSW. "Development of a semi-automatic method for cellular migration and division analysis." Awarded by:University of New South Wales. School of Biomedical Engineering, 2005. http://handle.unsw.edu.au/1959.4/20543.

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Binary image processing algorithms have been implemented in this study to create a background subtraction mask for the segmentation of cellular time lapse images. The complexity in the development of the background subtraction mask stems from the inherent difficulties in contrast resolution at the cellular boundaries. Coupling the background subtraction mask with the path reconstruction method via superposition of overlapping binary segmented objects in sequential time lapse images produces a semi-automatic method for cellular tracking. In addition to the traditional center of mass or centroid

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22

Burdyga, Alex. "Control of cAMP signalling in the cellular migration of pancreatic ductal adenocarcinoma." Thesis, University of Liverpool, 2013. http://livrepository.liverpool.ac.uk/12081/.

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Pancreatic ductal adenocarcinoma (PDAC) is characterised by a very high mortality rate and is the 4th most common cause of cancer death (Siegel et al., 2012). The disease initially develops asymptomatically, and at the time of diagnosis patients usually have multiple metastases (Rhim et al., 2012). It would therefore be highly desirable to develop treatments which specifically impede the ability of PDAC cells to metastasise by interfering with the cellular processes responsible for efficient cellular migration. Intracellular signalling cascades, which utilise various signalling proteins, ultim

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23

Cobb, Jessica Ann. "Design of a microfluidic device for inducing cellular deformation and quantifying migration." [Gainesville, Fla.] : University of Florida, 2009. http://purl.fcla.edu/fcla/etd/UFE0041079.

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24

Durand, Ellen Marie. "Regulation of hematopoietic stem cell migration and function." Thesis, Harvard University, 2014. http://dissertations.umi.com/gsas.harvard:11550.

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Hematopoietic stem cell transplantation (HSCT) is an effective treatment for blood disorders and autoimmune diseases. Following HSCT, these cells must successfully migrate to the marrow niche and replenish the blood system of the recipient. This process requires both non-cell and cell-autonomous regulation of hematopoietic stem and progenitor cells (HSPCs). A transgenic reporter line in zebrafish allowed the investigation of factors that regulate HSPC migration and function. To directly observe cells in their endogenous microenvironment, confocal live imaging was used to track runx1:GFP+ HSP

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Liu, Wei. "Tetraspanin KAI1/CD82 inhibits cell migration-related cellular events via reorganizing actin network." View the abstract Download the full-text PDF version, 2007. http://etd.utmem.edu/WORLD-ACCESS/Liu/2007-030-Liu.pdf.

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Thesis (M.S. )--University of Tennessee Health Science Center, 2007.<br>Title from title page screen (viewed on July 17, 2008). Research advisor: Xin Zhang, Ph.D. Document formatted into pages (xv, 197 p. : ill.). Vita. Abstract. Includes bibliographical references (p. 159-197).

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Wagstaff, Laura. "The cellular and molecular mechanisms controlling cardiac precursor cell migration in chick embryos." Thesis, University of East Anglia, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.437635.

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Zorn, Matthias [Verfasser], and Joachim [Akademischer Betreuer] Rädler. "Towards cellular hydrodynamics: collective migration in artificial microstructures / Matthias Zorn ; Betreuer: Joachim Rädler." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2018. http://d-nb.info/1188200070/34.

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Sawant, Anagha Chandrasekhar Anand. "Cellular behaviors regulating tangential migration of facial branchiomotor neurons in the zebrafish embryo." Diss., Columbia, Mo. : University of Missouri--Columbia, 2009. http://hdl.handle.net/10355/6541.

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The entire thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file; a non-technical public abstract appears in the public.pdf file. Title from PDF of title page (University of Missouri--Columbia, viewed on January 20, 2010). Thesis advisor: Dr. Anand Chandrasekhar. Includes bibliographical references.

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Riahi, Reza. "Engineered Molecular Probes for Systematic Studies of Cellular Response in Collective Cell Migration." Diss., The University of Arizona, 2013. http://hdl.handle.net/10150/312515.

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The investigation of complex biological processes, such as wound healing, cell migration, cancer cell invasion, and gene regulatory networks can be benefited tremendously by novel biosensing techniques with high stability and spatiotemporal resolution. In particular, molecular probes with qualities including high stability, sensitivity, and specificity are highly sought-after for long-term monitoring of gene expression in individual cells. Among different single-cell analysis techniques oligonucleotide optical probes is a promising detection method to monitor the dynamics of cellular responses

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Zorn, Matthias Verfasser], and Joachim [Akademischer Betreuer] [Rädler. "Towards cellular hydrodynamics: collective migration in artificial microstructures / Matthias Zorn ; Betreuer: Joachim Rädler." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2018. http://d-nb.info/1188200070/34.

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31

Vareed, Rebecca. "Characterizing the Cellular Nature of the Physical Interactions Necessary for Collective Neuron Migration." VCU Scholars Compass, 2019. https://scholarscompass.vcu.edu/etd/5895.

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Neuronal migration is an essential process in the development of the nervous system. Neurons are born in one location and migrate sizable distances to their final location. In many other developmental processes, cells migrate as collectives, where the migration of one cell influences the migration of another cell; this process has yet to be shown in the developing central nervous system. Using the conserved tangential migration of facial branchiomotor neurons (FBMNs), I aim to determine the nature of the collective migration in the developing nervous system. Here, two models of FBMN collective

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SCHIAVO, IRENE. "KRIT1 LOSS-OF-FUNCTION INDUCES ANGIOGENESIS AND MIGRATION IN A CCM CELLULAR MODEL." Doctoral thesis, Università di Siena, 2019. http://hdl.handle.net/11365/1072696.

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KRIT1 is a gene involved in Cerebral Cavernous Malformations (CCMs), a cerebrovascular disease characterized by thin-walled capillaries lacking of normal vessel structure that predispose to headaches, neurological deficits, seizures, stroke and intracerebral hemorrhage (ICH). KRIT1 protein presents a pleiotropic effect, by regulating multiple molecular mechanisms involved in redox homeostasis, angiogenesis, endothelial cellular permeability and alteration of cell-cell and cell- extracellular matrix (ECM) adhesion. The effective correlation between KRIT1 loss- of-function and CCM pathogenesis r

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Lautenschlaeger, Franziska. "Cell compliance : cytoskeletal origin and importance for cellular function." Thesis, University of Cambridge, 2011. https://www.repository.cam.ac.uk/handle/1810/239393.

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Mechanical properties of cells, mainly defined by their cytoskeleton, are closely related to cell function and can be measured with a dual-beam laser trap (optical stretcher). Functional changes, which go hand in hand with changes of the cytoskeleton, also occur during differentiation of stem cells. This suggests monitoring differentiation by the changing compliance of the cells. During the course of my PhD I measured the compliance of three different types of stem cells before and after differentiation and was able to detect differences in some of the cell types. In order to relate rheologica

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Wimmer, Ryszard. "Migration of neural stem cells during human neocortical development." Electronic Thesis or Diss., Université Paris sciences et lettres, 2024. http://www.theses.fr/2024UPSLS016.

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Chez les espèces gyrencéphaliques, et en particulier chez l'homme, la forte augmentation de la taille du néocortex est largement soutenue par une niche neurogénique élargie, la zone sous-ventriculaire externe (oSVZ). Cela est dû en grande partie à l'amplification d'une population de cellules souches neurales, les cellules gliales radiales basales (bRG, également appelées oRG). Les cellules bRG colonisent la zone sous-ventriculaire externe grâce à un mouvement dépendant de l'acto-myosine appelé translocation somale mitotique (MST). Le mécanisme moléculaire exact de la MST, la question de savoir

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Trichas, Georgios. "Elucidating the cellular basis for directional migration of anterior visceral endoderm in mouse embryo." Thesis, University of Oxford, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.510249.

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Steinwachs, Julian [Verfasser], Ben [Akademischer Betreuer] Fabry, and Andreas [Akademischer Betreuer] Bausch. "Cellular Forces during Migration through Collagen Networks / Julian Steinwachs. Gutachter: Ben Fabry ; Andreas Bausch." Erlangen : Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 2015. http://d-nb.info/1081544155/34.

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Kumar, Neil. "A computational and experimental study of HER2-signaling effects on cellular migration and proliferation." Thesis, Massachusetts Institute of Technology, 2006. http://hdl.handle.net/1721.1/39263.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering, February 2007.<br>Includes bibliographical references.<br>The fundamental question posed in this thesis is: how does a cell 'decide' to behave in a particular way? The human body is comprised of [approx.] 1014 cells that interpret extracellular information and respond with such behavior as migration, proliferation, apoptosis, or differentiation. Thirty years of research in the related fields of biochemistry, molecular biology, and genetics have demonstrated that, in most cases, the cellular decision-making p

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Bortone, Dante Stephen Polleux Franck. "Cellular and molecular mechanisms controlling pyramidal neuron and interneuron migration in the developing neocortex." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2008. http://dc.lib.unc.edu/u?/etd,2160.

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Thesis (Ph. D.)--University of North Carolina at Chapel Hill, 2008.<br>Title from electronic title page (viewed Feb. 26, 2009). "... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Curriculum of Neurobiology." Discipline: Neurobiology; Department/School: Medicine.

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Ware, James. "Optically manipulated control over micron-scale signalling dynamics for directing cellular differentiation and migration." Thesis, University of Nottingham, 2017. http://eprints.nottingham.ac.uk/39745/.

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Cellular microenvironments are an important area of study, and their implications with regard to development, tissue function, and disease, mean that they have particular relevance in tissue engineering. The development of tissue engineered therapeutics is underpinned by the understanding of how the cells exist in their natural environment. A fundamental lack of insight into the signalling mechanisms within microenvironments, due to in part a lack of appropriate technologies, has meant that the therapeutic potential of tissue engineering is limited. To this end, the development of a micropatte

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Ng, Mei Rosa. "Mechanical Regulation of Epithelial Cell Collective Migration." Thesis, Harvard University, 2012. http://dissertations.umi.com/gsas.harvard:10578.

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Cell migration is a fundamental biological process involved in tissue development, wound repair, and diseases such as cancer metastasis. It is a biomechanical process involving the adhesion of a cell to a substratum, usually an elastic extracellular matrix, as well as the physical contraction of the cell driven by intracellular actomyosin network. In the migration of cells as a group, known as collective migration, the cells are also physically linked to one another through cell-cell adhesions. How mechanical interactions with cell substratum and with neighboring cells regulate movements durin

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Fan, Yi. "POLARIZATION OF CYTOSKELETON-REGULATORY PROTEINS DURING ENDOTHELIAL CELL MIGRATION." Case Western Reserve University School of Graduate Studies / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=case1247148451.

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Sidhaye, Jaydeep. "Cellular dynamics in Zebrafish optic cup morphogenesis." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2018. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-232445.

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Organ formation is an important step during development of an organism that combines different scales from the molecular to the tissue level. Many organogenesis phenomena involve epithelial morphogenesis, where sheets of cells undergo rearrangements to form complex architectures – organ precursors, which subsequently develop into mature organs. Timely development of the characteristic architectures of the organ precursors is crucial for successful organogenesis and is determined by the choice of epithelial rearrangements that organise the constituent cells in space and time. However, for many

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Moazzam, Muhammad. "The role of the WASP family proteins in cellular migration and invasion in prostate cancer." Thesis, Cardiff University, 2014. http://orca.cf.ac.uk/60160/.

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Prostate cancer metastasis is a complex process, involving multiple pathways in its orchestration. Malignant cells are influenced by different growth factors from the extracellular environment which promote or inhibit cell movement and metastasis. HGF has been implicated in progression and metastasis of prostate cancer. A cell interacts with the environment through surface molecules like integrins. These interactions are further translated in to different responses through various intracellular machineries. Furthermore organization of the actin cytoskeleton is vital for many cellular functions

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Timpson, Paul. "A study examining the role of Rho family GTPases in the intracellular targeting of Src kinase during cell polarisation and migration." Thesis, University of Glasgow, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.248188.

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Vig, Dhruv Kumar. "Spanning the Continuum: From Single Cell to Collective Migration." Diss., The University of Arizona, 2015. http://hdl.handle.net/10150/566259.

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A cell's ability to sense and respond to mechanical signals highlights the significance of physical forces in biology; however, to date most biomedical research has focused on genetics and biochemical signaling. We sought to further understand the physical mechanisms that guide the cellular migrations that occur in a number of biological processes, such as tissue development and regeneration, bacterial infections and cancer metastasis. We investigated the migration of single cells and determined whether the biomechanics of these cells could be used to elucidate multi-cellular mechanisms. We fi

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Hyde-Dunn, James. "The motile responses elicited by the cytokine CSF-1 in a stable transfection model cellular migration." Thesis, King's College London (University of London), 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.266206.

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Rich, Kirsty. "Matrix metalloproteinases in asthma : the role of mast cells and basophils." Thesis, University of Southampton, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.285664.

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Barkefors, Irmeli. "Directing Angiogenesis : Cellular Responses to Gradients in vitro." Doctoral thesis, Uppsala universitet, Institutionen för medicinsk biokemi och mikrobiologi, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-145525.

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Blood vessels are essential for the delivery of nutrients and oxygen to tissues, as well as for the removal of waste products. Patients with tumors, wounds or diabetes all have active angiogenesis, formation and remodeling of blood vessels, a process that is initiated and manipulated by gradients of secreted signaling proteins. This thesis describes the development of new microfluidic in vitro assays where directed migration of single endothelial cells and three dimensional vascular structures can be monitored in real time. Combining these assays with live imaging microscopy we have studied th

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Suryo, Rahmanto Yohan. "THE PHYSIOLOGICAL AND PATHOPHYSIOLOGICAL ROLES OF MELANOTRANSFERRIN." Thesis, The University of Sydney, 2007. http://hdl.handle.net/2123/2439.

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Melanotransferrin or melanoma tumour antigen p97 (MTf) is a transferrin homologue that is found predominantly bound to the cell membrane via a glycosylphosphatidylinositol anchor. The molecule is a member of the transferrin super-family that binds iron through a single high affinity iron(III)-binding site. Melanotransferrin was originally identified at high levels in melanoma cells and other tumours, but at lower levels in normal tissues. Since its discovery, the function of MTf has remained intriguing, particularly regarding its role in cancer cell iron transport. In fact, considering the cru

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Suryo, Rahmanto Yohan. "THE PHYSIOLOGICAL AND PATHOPHYSIOLOGICAL ROLES OF MELANOTRANSFERRIN." Faculty Medicine, Department of Pathology, 2007. http://hdl.handle.net/2123/2439.

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Doctor of Philosophy(PhD)<br>Melanotransferrin or melanoma tumour antigen p97 (MTf) is a transferrin homologue that is found predominantly bound to the cell membrane via a glycosylphosphatidylinositol anchor. The molecule is a member of the transferrin super-family that binds iron through a single high affinity iron(III)-binding site. Melanotransferrin was originally identified at high levels in melanoma cells and other tumours, but at lower levels in normal tissues. Since its discovery, the function of MTf has remained intriguing, particularly regarding its role in cancer cell iron transport.

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