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Relevant bibliographies by topics / Cellular RNA / Dissertations / Theses

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Dissertations / Theses on the topic 'Cellular RNA'

Author: Grafiati

Published: 4 June 2021

Last updated: 20 February 2023

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1

Hunt, Sarah Louise. "Cellular proteins required for rhinovirus RNA translation." Thesis, University of Cambridge, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.313880.

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2

Chan, Annie Yee-Man. "Interactions between the influenza virus RNA polymerase and cellular RNA polymerase II." Thesis, University of Oxford, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.670083.

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3

Bailey, Daniel John. "Cellular proteins in picornavirus replication." Thesis, University of Reading, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.298484.

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4

Vasale, Jessica J. "Roles of Cellular RNA-Dependent RNA Polymerases in Endogenous Small RNA Pathways in Caenorhabditis elegans: A Dissertation." eScholarship@UMMS, 2010. https://escholarship.umassmed.edu/gsbs_diss/481.

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The RNA interference (RNAi) pathway in Caenorhabditis elegans is a two-step, small RNA-mediated silencing pathway. Unlike in other organisms, Dicer processing of double-stranded RNA into small interfering (si) RNAs is not sufficient in worms to induce gene silencing. The activity of cellular RNA-dependent RNA polymerase (RdRP) is necessary to synthesize a secondary pool of siRNAs, which interact with a unique class of Argonaute proteins to form the functional effector complexes that mediate silencing. The aims of this thesis were to: 1) characterize the role of RdRP family members in endogenou

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5

Osborn, Maire. "Cellular RNA Targeting by Platinum (II) Anticancer Therapeutics." Thesis, University of Oregon, 2014. http://hdl.handle.net/1794/17920.

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Cis-diamminedichloroplatinum (II), or cisplatin, is a widely prescribed anticancer compound, currently one of only three platinum (II) complexes FDA approved for cancer treatment. Despite its widespread use, we lack a comprehensive picture of global drug targets, which would lend valuable insights into the molecular mechanisms of action and resistance in different tissues. Drug binding to genomic DNA is an accepted cause of downstream apoptotic signaling, but less than 10% of Pt (in the case of cisplatin) accumulates within genomic DNA. Non-genomic contributions to cisplatin's therapeutic acti

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6

Brown, E. C. "Cellular proteins involved in translation of human rhinovirus RNA." Thesis, University of Cambridge, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.596963.

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Translation of picornavirus RNA takes place by internal initiation, determined by the presence of an internal ribosome entry site (IRES) in the 5'-untranslated region of the genomic RNA. Efficient translation from the human rhinovirus-2 (HRV-2) IRES is dependent on host cell <I>trans</I>-acting factors. These include unr, p38 and polypyrimidine tract binding protein (PTB). This thesis details the investigation into how these factors act to promote translation from the HRV-2 IRES. Unr, an RNA-binding protein with five cold-shock domains (CSDs), binds to the HRV-2 IRES and this interaction was s

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7

Todorova, Tanya (Tanya Todorova). "Function and regulation of PARP13 binding to cellular RNA." Thesis, Massachusetts Institute of Technology, 2015. http://hdl.handle.net/1721.1/97789.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Biology, 2015.<br>Cataloged from PDF version of thesis. Vita.<br>Includes bibliographical references.<br>Poly(ADP-ribose) polymerase-13 (PARP13) is a member of the PARP family of proteins - enzymes that use NAD+ to synthesize a posttranslational protein modification called poly(ADP-ribose) (PAR). PARPs function in multiple cellular pathways, and recently several members of the family have been implicated in regulating various steps in RNA metabolism, from splicing to translation and decay. PARP1 3 is the best-understood RNA-r

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8

Mullani, Nowsheen. "An RNA Signature Links Oxidative Stress To Cellular Senescence." Electronic Thesis or Diss., Sorbonne université, 2019. https://accesdistant.sorbonne-universite.fr/login?url=https://theses-intra.sorbonne-universite.fr/2019SORUS560.pdf.

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Le stress oxydatif est l’une des voies menant à la sénescence cellulaire. Bien que les dommages causés par les espèces réactives de l'oxygène aux protéines et à l'ADN soient bien décrits, notre compréhension de la manière dont la transcription peut participer à l'apparition de la sénescence est encore limitée. Au niveau de la transcription, le stress oxydatif entraîne l’accumulation d’ARN promoteurs (ARNAu) et d’ARN amplificateur (ARNs), conséquence de la libération défectueuse du RNAPII de la chromatine, un phénomène connu sous le nom de RNAPII crawling. Nous avons observé que l'exploration d

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9

Stassinopoulos, Ioannis A. "Interactions of picornavirus internal ribosome entry sites with cellular proteins." Thesis, University of Sussex, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.322940.

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10

Schmier, Brad J. "The Molecular Machinery Critical to the Degradation of Cellular RNA." Scholarly Repository, 2012. http://scholarlyrepository.miami.edu/oa_dissertations/714.

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Exoribonucleases are indispensable for cellular RNA metabolism. RNA processing, end-turnover, and degradation all require the concerted action of exoribonucleases. In this thesis, two families of exoribonucleases that act in the final steps of RNA decay pathways are explored. The first of these is the RNR superfamily of processive 3’→5’ RNases with major roles in both mRNA and stable RNA degradation. The initial focus of this work is the structural and enzymatic characterization of an unusual RNR family enzyme from the radiation-resistant bacterium Deinococcus radiodurans. This enzyme is d

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11

Tedeschi, Frank A. Tedeschi. "IDENTIFICATION OF CELLULAR RNA BINDING SITES OF DEAD-BOX HELICASES." Case Western Reserve University School of Graduate Studies / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=case1531217057171378.

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12

Idris, Jalilah. "Investigating novel roles of RNA binding proteins SAFB1 and SAFB2 in RNA processing and in cellular stress." Thesis, University of Bristol, 2017. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.738206.

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13

Cordiner, Ross Andrew Alex. "The cellular functions of the microprocessor complex." Thesis, University of Edinburgh, 2016. http://hdl.handle.net/1842/25877.

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DGCR8 (DiGeorge critical region 8) protein constitutes part of the Microprocessor complex together with Drosha, and is involved in the nuclear phase of microRNA (miRNA) biogenesis. DGCR8 recognises the hairpin RNA substrates of precursor miRNAs through two double-stranded RNA (dsRNA) binding motifs and acts as a molecular anchor to direct Drosha cleavage at the base of the pri-miRNA hairpin. Recent characterisation of the RNA targets of the Microprocessor by HITSCLIP of DGCR8 protein revealed that this complex also binds and regulates the stability of several types of transcripts, including mR

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14

Ozes, Ali Rayet. "Targeting the long non coding RNA HOTAIR in cancer." Thesis, Indiana University, 2016. http://pqdtopen.proquest.com/#viewpdf?dispub=10154781.

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<p> Ovarian cancer (OC) takes the lives of nearly 14,000 US women every year. Although platinum is one of the most effective drugs in treating ovarian cancer, the development of platinum resistance is one of the biggest challenges facing patients. I have shown that the long non-coding RNA HOTAIR contributes to platinum-resistant OC and determined the regulators and targets of HOTAIR during the platinum-induced DNA damage response. My published data supports the role of HOTAIR in contributing to DNA damage induced cellular senescence and secretion of pro-inflammatory cytokines leading to cispla

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15

Babendure, Jeremy R. "Utilizing RNA structure as a tool in molecular and cellular biology." Diss., Connected to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2005. http://wwwlib.umi.com/cr/ucsd/fullcit?p3190000.

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Thesis (Ph. D.)--University of California, San Diego, 2005.<br>Title from first page of PDF file (viewed Mar. 6, 2006). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references (p. 122-131).

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16

Nurmohamed, Salima. "Communication between the Escherichia coli RNA degradative machineries and cellular metabolism." Thesis, University of Cambridge, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.611286.

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17

Öhrmalm, Christina. "Functional characterization of the cellular protein p32 : a protein regulating adenovirus transcription and splicing through targeting of phosphorylation /." Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-6794.

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18

McNally, Beth Anne. "A role for cytoplasmic PML in the cellular antiviral response." Columbus, Ohio : Ohio State University, 2005. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1133377007.

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19

York, Ashley D. "A study of viral and cellular factors in the regulation of the influenza virus RNA-dependent RNA polymerase." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:5958fafd-4c91-4434-910e-29e2dd0539b9.

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The segmented negative-sense vRNA genome of influenza A virus is replicated via a complementary RNA (cRNA) intermediate by the viral RNA-dependent RNA polymerase (RdRP). The replicative intermediate has been thought to exist as a complementary ribonucleoprotein (cRNP) complex. Development of an RNA-based affinity-purification strategy for the isolation of viral ribonucleoprotein complexes enabled the structural and functional characterisation of the previously uncharacterised cRNP complex. The cRNP exhibits a filamentous double-helical organisation with defined termini, containing the viral Rd

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20

Jeyaraj, Selvi Chrysolyte. "A role for the mRNA-stabilizing protein HuR in protection from cellular ATP depletion." Columbus, Ohio : Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1186773861.

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21

Wong, Tsz-lo, and 黃子璐. "Cellular role of miR-143 in cervical cancer." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hub.hku.hk/bib/B48274045.

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Cervical cancer is a largely preventable malignancy due to the availability of cytology screening and vaccination against the essential initiation factor of cervical carcinogenesis, human papillomavirus (HPV). However, cervical cancer remains a significant medical burden worldwide, particularly in developing countries where large scale screening or vaccination programs are not financially feasible. Molecular tests such as HPV DNA tests have the potential to improve the speed and sensitivity of cervical cancer screening but suffer from limited specificity. Additional adjunct molecular markers

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22

Schonauer, Melissa. "Intersection of RNA Processing and Fatty Acid Synthesis and Attachment in Yeast Mitochondria." Diss., The University of Arizona, 2008. http://hdl.handle.net/10150/194674.

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Intersections of distinct biological pathways in cells allow for nodes of metabolic regulation. This work describes the discovery of the intersection of two pathways in yeast mitochondria: RNA processing and fatty acid synthesis and attachment. Analysis of the components of the pathways is presented here along with a model illustrating the connection as a potential mode of regulation of mitochondrial gene expression.A genome-wide screen of respiratory-deficient <italic>Saccharomyces cerevisiae</italic> deletion strains for defects in mitochondrial RNA processing revealed that two novel genes a

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23

Mahmoudi, Massoud. "Induction of Interferon Messenger RNA and Expression of Cellular Oncogenes in Human Lymphoblastoid Cells." Thesis, North Texas State University, 1986. https://digital.library.unt.edu/ark:/67531/metadc798199/.

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The purposes of this study was to demonstrate the induction of alpha interferon mRNA in Sendai virus-induced Namalava cells, to follow the level of alpha interferon mRNA synthesis at the transcriptional level, and to determine whether the Namalava cell line expresses the c-myc oncogene and to what degree. The amount of c-myc message deteted in Namalva cell RNA was about one-tenth that of Daudi cell RNA, whereas no difference in the amount of the c-Ha-ras message was observed between the two cell lines.

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24

Mina, Ibarra Leonardo Bruno. "Cellular mRNA decay factors involved in the hepatitis C virus life cycle." Doctoral thesis, Universitat Pompeu Fabra, 2010. http://hdl.handle.net/10803/7215.

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The group of positive strand RNA ((+)RNA) viruses includes numerous plant, animal and human pathogens such as the hepatitis C virus (HCV). Their viral genomes mimic cellular mRNAs, however, besides acting as messengers for translation of viral proteins, they also act as templates for viral replication. Since these two functions are mutually exclusive, a key step in the replication of all (+) RNA viruses is the regulated exit of the genomic RNAs from the cellular translation machinery to the viral replication complexes. By using a model system that allows the replication of the plant (+) RNA Br

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25

Plakos, Kory. "Platinum-seq: High-throughput mapping of small-molecule platinum adducts on cellular RNA." Thesis, University of Oregon, 2017. http://hdl.handle.net/1794/22269.

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Methods to map small-molecule interactions with cellular RNAs are important for understanding endogenous activation, such as in riboswitches, as well as the potential for exogenous compounds to target RNA. Cisplatin is one of the most widely used of the platinum anticancer drugs that are prescribed in approximately 40-50% of all chemotherapy treatments (Dyson and Sava, 2006; Harper et al., 2010). Despite nearly 40 years of experience with this class of drugs, we still lack a comprehensive understanding of the targets of Pt compounds and their effects on cells. Pt(II) compounds are well-known D

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26

Chambers, A. "RNA 3' cleavage and polyadenylation in oocytes, eggs and embryos of Xenopus laevis." Thesis, University of Warwick, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.380275.

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27

Rubilar, Guzman Paulina. "Cellular host factors involved in the translation of the HIV-1 genomic RNA." Thesis, Lyon, École normale supérieure, 2015. http://www.theses.fr/2015ENSL1009/document.

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Le virus de l’immunodéficience humaine de type 1 (VIH-1) est un virus à simple brin positif qui appartient au genre Lentivirus dans la famille retroviridae et qui constitue l’agent étiologique du SIDA pandémique.Pendant le cycle réplicatif du VIH-1, la traduction de protéines virales dépend exclusivement de la machinerie traductionnelle cellulaire. Pour cette raison, nous avons cherché à comprendre le rôle de quelques facteurs cellulaires qui pourraient contrôler la traduction du VIH-1 à différents nivaux. Nous avons centré nos recherches sur la traduction de l’ARN génomique (ARNg) du virus qu

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28

Win, Maung Nyan Parker Carl Stevens Smolke Christina D. "Engineering RNA devices for gene regulation, biosensing, and higher-order cellular information processing /." Diss., Pasadena, Calif. : Caltech, 2008. http://resolver.caltech.edu/CaltechETD:etd-05282008-142750.

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29

Palsule, Geeta. "Mechanism and Functional Consequences of Generating and Processing Drosophila RNase P RNA from an Intron." The Ohio State University, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=osu1555628225881656.

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30

Kheimar, Ahmed Mahmoud Osman [Verfasser]. "Tumor promoting functions of cellular telomerase RNA and viral RNAs in herpesvirus-induced cancer formation / Ahmed Mahmoud Osman Kheimar." Berlin : Freie Universität Berlin, 2017. http://d-nb.info/1147758247/34.

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31

Ostertag, Derek Glenn. "Novel dsRNA-dependent activation of a cellular antiviral response to vesicular stomatitis virus /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2005. http://wwwlib.umi.com/cr/ucsd/fullcit?p3167840.

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32

Childs, April Celeste. "The Effects of EIF5A and of the Polyamines on RNA Processing, Translation, and P-Body Formation." Diss., Tucson, Ariz. : University of Arizona, 2005. http://etd.library.arizona.edu/etd/GetFileServlet?file=file:///data1/pdf/etd/azu%5Fetd%5F1326%5F1%5Fm.pdf&type=application/pdf.

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33

Guo, Bing. "Positive correlation between cellular levels of storage compounds and RNA in activated sludge bacteria." Thesis, McGill University, 2012. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=107874.

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In order to implement rational solutions to solids separation problems such as bulking and foaming and to rationally design new processes for the production of value-added products, it is necessary to understand the ecological functions and dynamics of heterotrophic bacterial populations inhabiting activated sludge wastewater treatment plants. Although phylogenetic (DNA- and RNA-based) characterization of these microbial communities demonstrated their wide diversity, the link between heterotrophic populations and specific functional niches is still tenuous. Because RNA levels are related to th

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34

Wang, Dong 1975. "Cisplatin-induced nucleosome and RNA polymerase II modification mediate cellular response to the drug." Thesis, Massachusetts Institute of Technology, 2004. http://hdl.handle.net/1721.1/28693.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 2004.<br>Vita.<br>Includes bibliographical references.<br>(cont.) with recombinant material. The in vitro system established in this study will facilitate the investigation of platinum-DNA damage by DNA repair processes and help elucidate the role of specific post-translational modification in NER of platinum-DNA adducts at the physiologically relevant nucleosome level. Chapter 3: Nucleotide Excision Repair of Site-Specifically Platinum-Modified Tetrasomes. The nucleosome, the basic structural unit of chromatin, is com

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35

Ribeiro, Diogo. "Discovery of the role of protein-RNA interactions in protein multifunctionality and cellular complexity." Thesis, Aix-Marseille, 2018. http://www.theses.fr/2018AIXM0449/document.

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Au fil du temps, la vie a évolué pour produire des organismes remarquablement complexes. Pour faire face à cette complexité, les organismes ont développé une pléthore de mécanismes régulateurs. Par exemple, les mammifères transcrivent des milliers d'ARN longs non codants (ARNlnc), accroissant ainsi la capacité régulatrice de leurs cellules. Un concept émergent est que les ARNlnc peuvent servir d'échafaudages aux complexes protéiques, mais la prévalence de ce mécanisme n'a pas encore été démontrée. De plus, pour chaque ARN messager, plusieurs régions 3’ non traduites (3’UTRs) sont souvent prése

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36

Saini, Harleen. "Intron and Small RNA Localization in Mammalian Neurons." eScholarship@UMMS, 2019. https://escholarship.umassmed.edu/gsbs_diss/1044.

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RNA molecules are diverse in form and function. They include messenger RNAs (mRNAs) that are templates for proteins, splice products such as introns that can generate functional noncoding RNAs, and a slew of smaller RNAs such as transfer RNAs (tRNAs) that help decode mRNAs into proteins. RNAs can show distinct patterns of subcellular localization that play an important role in protein localization. However, RNA distribution in cells is incompletely understood, with prior studies focusing primarily on RNAs that are long (>200 nucleotides), fully processed, and polyadenylated. We examined the di

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37

Svensson, Valentine. "Probabilistic modelling of cellular development from single-cell gene expression." Thesis, University of Cambridge, 2017. https://www.repository.cam.ac.uk/handle/1810/267937.

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The recent technology of single-cell RNA sequencing can be used to investigate molecular, transcriptional, changes in cells as they develop. I reviewed the literature on the technology, and made a large scale quantitative comparison of the different implementations of single cell RNA sequencing to identify their technical limitations. I investigate how to model transcriptional changes during cellular development. The general forms of expression changes with respect to development leads to nonparametric regression models, in the forms of Gaussian Processes. I used Gaussian process models to inv

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38

Kolisnichenko, Marina. "The role of the polyadenylation site of the melanocortin 1 receptor in generating MC1R-TUBB3 chimeras and attenuation of TORC1 delays the onset of replicative and RAS-induced cellular senescience." Thesis, University of Oxford, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.711654.

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39

Cooper, Samuel J. "Proteomic investigation of factors binding Gurken RNA in Drosphila and Hepatitis C virus cellular interactions." Thesis, University of Oxford, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.540148.

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40

Burns, David M. "Post-Transcriptional Control of Human Cellular Senescence: A Dissertation." eScholarship@UMMS, 2010. https://escholarship.umassmed.edu/gsbs_diss/491.

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The central dogma of biology asserts that DNA is transcribed into RNA and RNA is translated into protein. However, this overtly simplistic assertion fails to portray the highly orchestrated and regulated mechanisms of transcription and translation. During the process of transcription, RNA provides the template for translation and protein synthesis as well as the structural and sequence specificity of many RNA and protein-based machines. While only 1-5% of the genome will escape the nucleus to be translated as mRNAs, complex, parallel, highly-conserved mechanisms have evolved to regulate specif

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Smith, Gregory Robert. "Unraveling the Role of Cellular Factors in Viral Capsid Formation." Research Showcase @ CMU, 2015. http://repository.cmu.edu/dissertations/475.

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Understanding the mechanisms of virus capsid assembly has been an important research objective over the past few decades. Determining critical points along the pathways by which virus capsids form could prove extremely beneficial in producing more stable DNA vectors or pinpointing targets for antiviral therapy. The inability of current experimental technology to address this objective has resulted in a need for alternative approaches. Theoretical and computational studies offer an unprecedented opportunity for detailed examination of capsid assembly. The Schwartz Lab has previously developed a

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42

Zhang, Wei. "Functional elucidation of BS69 /." View abstract or full-text, 2008. http://library.ust.hk/cgi/db/thesis.pl?BICH%202008%20ZHANG.

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43

Bryant, Helen Elizabeth. "Analysis of cellular and viral proteins that interact with the IE63 protein of herpes simplex virus type 1." Thesis, University of Glasgow, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.312135.

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44

Zangl, Maximiliane Sophie [Verfasser]. "Influence of Viral Proteins and Cellular Exoribonuclease Xrn1 on RNA Recombination in Pestiviruses / Maximiliane Sophie Zangl." Hannover : Bibliothek der Tierärztlichen Hochschule Hannover, 2015. http://d-nb.info/1073954560/34.

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45

Vreeland, Amanda C. "Cellular Retinoic Acid-Binding Protein 2 Cooperates with HuR to Stabilize RNA and Inhibit Tumor Growth." Case Western Reserve University School of Graduate Studies / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=case1409933949.

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46

Xu, Kai. "KEY ROLES OF SUB-CELLULAR MEMBRANES AND CO-CHAPERONE IN TOMBUSVIRUS REPLICATION." UKnowledge, 2014. http://uknowledge.uky.edu/plantpath_etds/15.

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Positive strand RNA viruses, inculding tombusviruses, are known to utilize cellular membranes to assemble their replicase complexes (VRCs). Two tombusviruses , Tomato bushy stunt virus (TBSV) and Carnation Italian ringspot virus (CIRV), replicate on different organellar membranes, peroxisomes or endoplasmic reticulum (ER) for TBSV and mitochodria outer membranes in case of CIRV. I showed that both TBSV and CIRV replicase proteins could assemble VRCs and replicate viral RNA on purified microsomes (ER) and mitochondria. Different efficiencies of assembly was shown determined by multiple domains

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47

TenOever, Benjamin R. "Cellular recognition of RNA virus infection leading to activation of interferon regulatory factors three and seven and establishment of the antiviral state." Thesis, McGill University, 2004. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=84849.

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Virus infection represents an intracellular invasion of host cells for the sole purpose of multiplication. Successful virus replication requires entry into tropic cells, usurping of the cellular machinery, and the production of progeny virions to initiate further rounds of infection. Establishment of the antiviral state in response to virus begins at the site of infection and requires the initiation of a preexisting signaling network designed to inhibit virus replication and aid in the establishment of this coordinated immune response. Integral components of this network include the IRF

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48

Nitin, Nitin. "Optical and MR Molecular Imaging Probes and Peptide-based Cellular Delivery for RNA Detection in Living Cells." Diss., Available online, Georgia Institute of Technology, 2005, 2005. http://etd.gatech.edu/theses/available/etd-08102005-120350/.

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Thesis (Ph. D.)--Biomedical Engineering, Georgia Institute of Technology, 2006.<br>Dr. X. Hu, Committee Member ; Dr. Al Merrill, Committee Member ; Dr. Niren Murthy, Committee Member ; Dr. Gang Bao, Committee Chair ; Dr. Nicholas Hud, Committee Member. Includes bibliographical references.

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49

Galão, Rui Pedro Ribeiro. "Role of the cellular decapping activator LSM1-7 complex in the replication of positive-strand RNA viruses." Doctoral thesis, Universitat Pompeu Fabra, 2010. http://hdl.handle.net/10803/7222.

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By using the ability of the positive-strand RNA ((+)RNA) virus BMV to replicate in yeast it was previously shown that subunits of the LSm1-7 ring, as well as Pat1 and Dhh1 play an essential role in the transit of the BMV genome from translation to replication. In non-infected cells, these proteins mediate the transition of cellular mRNAs from a translational to a non-translational state by activating decapping in the 5'-3' - deadenylation-dependent mRNA decay pathway. Given the conservation of this pathway from yeast to humans and the common need of all (+)RNA viruses to regulate the transitio

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Hopkins, M. J. "Characterisation of the human intestinal microbiota based on community cellular fatty acid analysis and ribosomal RNA measurements." Thesis, University of Cambridge, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.604222.

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Chemostat studies were undertaken to validate the correlation between bacterial growth rate and 16S ribosomal RNA content for intestinal isolates, and also to identify potential 'signature' cellular fatty acids (CFA) for use as markers of bacterial community structure. These two methods were then used, in conjunction with traditional techniques, to investigate changes in the human colonic microflora associated with carbohydrate metabolism, antibiotic administration, and the ageing process. Short chain carbohydrates (SCC) were used to manipulate the composition and activities of the intestinal

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