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Dissertations / Theses on the topic 'Cellule Mononucleate'

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1

Silva, Walkiria Ferreira. "Comparação da viabilidade das células mononucleares totais da medula óssea de suínos em diferentes protocolos de congelamento." Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/10/10132/tde-18032008-151448/.

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A necessidade de tratamentos mais eficazes e menos invasivos para os pacientes, em adição à capacidade de diferenciação celular da medula óssea sugere que o transplante de células mononucleares totais poderia ser uma das melhores formas de tratamento para as diversas patologias existentes. Entretanto, vários fatores implicam sobre a viabilidade das células da medula óssea dos quais destacamos a ausência de padronização de protocolo de criopreservação que permita a manutenção da viabilidade celular, sendo altamente necessário o desenvolvimento de estudos nesta área. Deste modo, neste estudo, ap
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2

ALARY, FLORENCE. "Nephropathie interstitielle aigue abacterienne : etude nosologique, anatomo-pathologique et etiopathogenique." Toulouse 3, 1992. http://www.theses.fr/1992TOU31099.

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3

Chalmers, Isobel Margaret Hood. "Cellular and cytokine profile of cord and adult blood mononuclear cells." Thesis, University of Aberdeen, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.324413.

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Umbilical cord blood (CB) has been used as a source of haemopoietic stem cells in both related and unrelated bone marrow transplantation and in both settings there appears to be a reduced incidence of graft-versus-host disease (GVHD) when compared to bone marrow transplantation. The aim of this study was to perform a phenotypic and cellular analysis of both cord and adult mononuclear cells <I>in vitro</I> in order to identify any immunological characteristic that could account for the apparent reduced incidence of GVHD observed, <I>in vivo</I>. For this, the cell surface phenotype, allogeneic
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4

Davies, Euryl Howell. "An investigation of iron metabolism in cells of the mononuclear phagocyte system." Thesis, University of Bristol, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.330323.

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5

Buzzetto, Lilian Cristina. "Estudo molecular da via extrínseca da apoptose em indivíduos com imunodeficiência comum variável." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/42/42133/tde-18092012-110222/.

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A Imunodeficiência de Variável Comum (ICV) é caracterizada por baixos níveis de imunoglobulinas com susceptibilidade a. Analisamos a distribuição de linfócitos, apoptose espontânea e a expressão gênica de receptores de morte, ligantes, adaptadores, moléculas reguladoras, inibidoras e anti-apotóticas em células CD4+ e CD8+ de 19 pacientes ICV e 19 controles. Pacientes com ICV apresentam diminuição na frequência de linfócitos TCD4+ e CD4+CD45RA+ e menor relação CD4/CD8 que indivíduos saudáveis. O grupo de pacientes mostrou maior frequência de apoptose espontânea em linfócitos totais e CD4+. Cé
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6

Zoulim, Fabien. "Signification de l'expression des proteines pre-s1 dans le serum et les cellules mononucleees du sang au cours des infections chroniques dues au virus de l'hepatite b." Lyon 1, 1990. http://www.theses.fr/1990LYO1M151.

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7

Pereira, Andréa Mendes. "Ativação de células mononucleares caninas por interleucina-2 e interleucina -12 recombinantes homólogas." reponame:Repositório Institucional da FIOCRUZ, 2006. https://www.arca.fiocruz.br/handle/icict/5882.

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Submitted by Ana Maria Fiscina Sampaio (fiscina@bahia.fiocruz.br) on 2012-11-27T17:22:07Z No. of bitstreams: 1 Andréa Mendes Pereira Ativação de celulas... 2006.pdf: 40276494 bytes, checksum: 9f4656b98e4c74bae9c81e7797e85988 (MD5)<br>Made available in DSpace on 2012-11-27T17:22:07Z (GMT). No. of bitstreams: 1 Andréa Mendes Pereira Ativação de celulas... 2006.pdf: 40276494 bytes, checksum: 9f4656b98e4c74bae9c81e7797e85988 (MD5) Previous issue date: 2006<br>Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Bahia, Brasil<br>Visando avaliar futuramente o potencial de citoci
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8

Pourshafie, Mohammed R. "Modifications in Cellular Responses of Mononuclear Cells Exposed to Mycobacterium Avium Serovar-specific Glycopeptidolipid and Its Lipopeptide Fragment." Thesis, University of North Texas, 1992. https://digital.library.unt.edu/ark:/67531/metadc278939/.

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Immunological and ultrastructural changes in mononuclear cells exposed to Mycobacterium avium serovar-specific glycopeptidolipid (GPL) and the chemically derived R-lipid (lipopeptide fragment) were examined.
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9

Oliveira, Sheilla Andrade de. "Estudo do potencial terapêutico de células mononucleares de medula óssea em lesões hepáticas crônicas em camundongos." reponame:Repositório Institucional da FIOCRUZ, 2007. https://www.arca.fiocruz.br/handle/icict/4301.

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Submitted by Ana Maria Fiscina Sampaio (fiscina@bahia.fiocruz.br) on 2012-08-29T20:29:44Z No. of bitstreams: 1 Sheilla Andrade deOliveira. Estudo do potencial terapêutico de células mononucleares de medula óssea em lesões hepáticas crônicas em camundongos - UFBA-FIOCRUZ-CPqGM - Tese Doutorado.pdf: 16762445 bytes, checksum: f804f2624774de877295c8841f4ff9c1 (MD5)<br>Made available in DSpace on 2012-08-29T20:29:44Z (GMT). No. of bitstreams: 1 Sheilla Andrade deOliveira. Estudo do potencial terapêutico de células mononucleares de medula óssea em lesões hepáticas crônicas em camundongos - UFBA-F
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10

Mutez, Eugénie. "Apport du transcriptome des cellules mononucléées sanguines à l’étude de cas familiaux et sporadiques atteints de la maladie de Parkinson." Thesis, Lille 2, 2011. http://www.theses.fr/2011LIL2S033/document.

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La maladie de Parkinson (MP) est caractérisée par la mort des neurones dopaminergiques de la substance noire et la présence de corps de Lewy. Son diagnostic reste sujet à des erreurs notamment aux stades précoces. Les cellules mononucléées sanguines périphériques (PBMC) jouent un rôle dans la cascade délétère et sont le reflet d’événements associés à la MP. Même si elles ne représentent qu’un faible pourcentage, les formes génétiquement déterminées permettent d’identifier des sujets à un stade précoce. Nous avons émis l’hypothèse que les PBMC pouvaient constituer un modèle d’étude reflétant ce
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11

Godman, Jennifer Delgado BVMS MRCVS. "The effect of hypothermia on influx of mononuclear cells in the digital lamellae of horses with oligofructose-induced laminitis." The Ohio State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=osu1462843751.

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12

Liu, Yu-li. "Comparison of Beta-adrenoceptor Coupled Camp Production in Cultured Human Mononuclear Leukocytes and Myometrial Cells." Digital Commons @ East Tennessee State University, 1997. https://dc.etsu.edu/etd/2940.

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$\beta\sb2$-Adrenoceptor ($\beta\sb2$-AR) agonists, such as terbutaline, are used as tocolytic agents in the treatment of preterm labor. $\beta$-Adrenoceptor stimulation relaxes myometrium through specific receptors coupled through Gs to adenylyl cyclase (AC) that catalyzes the conversion of ATP to cAMP. The purpose of this study was to compare $\beta$-adrenoceptors and cAMP production in cultured human leukocytes and myometrial cells, and to determine the importance of $\beta$-adrenoceptors and cAMP production in isoproterenol-induced myometrial relaxation. $\sp{125}$I-iodopin
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13

Askew, Sandra Lyn. "Cytokine signalling functions of human soluble IgE receptors in peripheral blood mononuclear cells from normal and hyper-allergic individuals and in B-lymphoblastoid and monocytic cell lines." Thesis, Nelson Mandela Metropolitan University, 2006. http://hdl.handle.net/10948/455.

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CD23 is a multifunctional receptor/ligand, found in a variety of cell types, such as human peripheral blood mononuclear cells (PBMCs), B-lymphoblastoid cell lines, mast cells and basophils. It is also found on a variety of haematopoietic cell lines. As the low-affinity receptor for immunoglobulin E (IgE), CD23 plays a role in antigen-presentation and macrophage activation. As a surface molecule cleaved from the cell membrane, soluble CD23 (sCD23) can act as an adhesion molecule and a cytokine. Perturbances of such molecular interactions may lead to various diseases such as allergies and other
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14

Mathieu, Myrielle. "Comparison between therapeutic efficiency of bone marrow derived mononuclear and mesenchymal stem cells in chronic myocardial infarction." Doctoral thesis, Universite Libre de Bruxelles, 2009. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/210138.

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<p>Background: Stem cell therapy can facilitate cardiac repair after healed myocardial infarction but the optimal cell type remains uncertain. <p>Aims: To investigate the pathophysiology of heart failure in a canine model of healed myocardial infarction and to compare the efficacy and the safety of autologous bone marrow mononuclear cell (BMNC) transfer and mesenchymal stem cell (MSC) transfer in this model. It was a blind, randomized and placebo control study.<p>Methods: Eleven weeks after coronary ligation, 24 dogs received intramyocardial injections of BMNC, MSC or Placebo (n = 8 per groups
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15

Knaust, Eva. "Experimental studies on multidrug resistance in human leukaemia : role of cellular heterogeneity for daunorubicin kinetics /." Linköping : Dept. of Medicine and Care, Univ, 2005. http://www.bibl.liu.se/liupubl/disp/disp2005/med901s.pdf.

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16

Cabrera, Aulestia Francisco Javier. "Treating Cellular Stress and Damage : Use of Healthy Mitochondria Isolated from Donor Cells in the Artificial Mitochondria Transfer / Transplant (Amt/T) to Repair Mitochondrial Disfunction in Differentiated (Peripheral Blood Mononuclear Cells) and Germinal Cells (Oocytes)." Thesis, Montpellier, 2019. http://www.theses.fr/2019MONTT073.

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Selon la théorie endosymbiotique, la mitochondrie est un organite dérivé d'une ancienne alpha-protéobactérie qui développa une symbiose avec un ancêtre eucaryote. L'ADN mitochondrial (ADNmt) existe dans des centaines à des milliers d'exemplaires dans chaque cellule et code pour 13 protéines structurelles qui sont des sous-unités de la chaîne respiratoire. Les mitochondries génèrent de l'énergie pour les processus cellulaires en produisant de l'ATP par phosphorylation oxydative. Ils contrôlent également d’autres processus tels que la synthèse de nucléotide et d’hème, l’équilibre rédox, le métab
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17

Tron, Camille. "Étude des relations entre concentrations sanguines, biliaires, intracellulaires, et effet immunosuppresseur du tacrolimus en transplantation hépatique." Thesis, Rennes 1, 2019. http://www.theses.fr/2019REN1B038.

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Le tacrolimus est la pierre angulaire du traitement préventif du rejet de greffe en transplantation hépatique. Les posologies de tacrolimus doivent être adaptées aux patients en fonction des concentrations résiduelles sanguines mesurées tout au long du traitement. Cependant, ce suivi thérapeutique pharmacologique présente des limites puisque la réponse au tacrolimus n’est pas optimale chez tous les patients. Dans ce contexte, ce travail avait pour objectifs d’évaluer l’intérêt de nouveaux biomarqueurs de suivi pharmacologique du tacrolimus chez les patients transplantés hépatiques. Un premier
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18

Lemaitre, Florian. "Optimisation des thérapeutiques immunosuppressives par méthode pharmacologique." Thesis, Paris 11, 2014. http://www.theses.fr/2014PA114832/document.

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Les immunosuppresseurs sont des médicaments ayant démontré leur efficacité dans la prévention du rejet de transplantation d’organe solide. Néanmoins, ces médicaments présentent une importante variabilité de la réponse pharmacologique notamment liée à une variation de leur pharmacocinétique. Cette variabilité peut être à l’origine d’un défaut d’efficacité du traitement ou de sur-expositions entrainant une toxicité. Le suivi thérapeutique pharmacologique (STP) des concentrations sanguines d’immunosuppresseur permet de limiter ces risques de sur ou de sous-exposition en facilitant l’adaptation de
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19

Pellati, Donatella. "Co-individuazione delle isoforme di mRNA per il recettore dei mineralcorticoidi (MR) e dell' enzima 11ß-idrossisteroide deidrogenasi in cellule e tessuti umani atipici, rispondenti all'aldosterone. Studio particolareggiato in pazienti affetti da iperaldosteronismo primitivo e ricerca di mutazioni nel gene MR in una famiglia con diagnosi di pseudo-ipoaldosteronismo." Doctoral thesis, Università degli studi di Padova, 2008. http://hdl.handle.net/11577/3425495.

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The steroid hormone aldosterone, that normally controls the urinary Na+/K+ balance, and the osmolarity in the kidney, colon, salivary and swab glands epithelial tissues, exerts also many different effects, by binding to the mineralocorticoid receptor (MR). This receptor binds both aldosterone and glucocorticoids (mostly cortisol) with approximately the same affinity. However, cortisol has a 1000-fold higher concentration in plasma than that of aldosterone. In its classical target tissues, the mineralocorticoid selectivity mainly depends on the enzymatic activity of the type 2 11ß-hydroxystero
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20

Potiron, Laurent. "Rôle des phagocytes mononuclées dans la réponse immunitaire innée contre cryptosporidium parvum." Thesis, Tours, 2016. http://www.theses.fr/2016TOUR3809.

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Les nouveau-nés (enfants, ruminants) sont particulièrement sensibles à l’infection intestinale par le parasite Cryptosporidium parvum car leur système immunitaire est encore en cours de développement. Peu de solutions de contrôle existent à ce jour. Il n’existe pas de vaccin et seule une molécule l’Halocur™ possède une AMM pour les veaux mais l’utilisation du traitement est contraignante et il peut présenter une toxicité pour l’animal. Le développement de nouvelles alternatives immunoprophylactiques requiert de mieux comprendre les mécanismes immunitaires mis en jeux lors de l’infection. L’imm
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21

Souki, Rima. "Utilisation des miARN circulants comme indicateurs d'exposition aux hydrocarbures aromatiques polycycliques seuls et en mélange." Electronic Thesis or Diss., Université de Rennes (2023-....), 2023. http://www.theses.fr/2023URENB015.

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Les Hydrocarbures Aromatiques Polycycliques (HAP) sont des polluants environnementaux majeurs présentant des effets toxiques sur la santé humaine. Parmi les types cellulaires ciblés par les HAP, se trouvent les cellules mononucléaires circulantes du sang (PBMC). La présente étude vise à 1) étudier l'effet du B[a]P, HAP de référence, sur le profil d'expression des microARN (miRNA)in vitro dans les PBMC, ainsi que dans les vésicules extracellulaires (EV) sécrétées par ces cellules, en utilisant une approche de small RNA-seq, 2) Confirmer la présence de miRNA vésiculaires in vivo dans le plasma d
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22

CARELLA, SARA. "NUOVE OPZIONI TERAPEUTICHE NEL CAMPO DELLA CHIRURGIA RIGENENERATIVA PER IL TRATTAMENTO DELLE DISTROFIE VULVARI FISIOLOGICHE E PATOLOGICHE." Doctoral thesis, 2017. http://hdl.handle.net/11573/935742.

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La nostra Unità Operativa si dedica da diversi anni ad approfondire il tema dell'applicazione delle cellule staminali in Medicina Rigenerativa. In particolare, abbiamo contribuito allo sviluppo di protocolli terapeutici alternativi al trapianto di tessuto, dapprima mediante la ricostruzione di epiteli semplici (cute) e di mucose (orale, vaginale, uretrale, congiuntivale da biopsia di congiuntiva), e poi dedicandoci alla ricostituzione di alcuni tessuti mesenchimali come cartilagine, osso e tendini, mediante l'utilizzo delle cellule staminali mesenchimali di derivazione adiposa. Sulla base dei
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23

Adassi, Ines. "Evaluating the Antileukemic and Antiviral Activity of TH9402-Photodepleted Peripheral Blood Mononuclear Cells." Thèse, 2018. http://hdl.handle.net/1866/22800.

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