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Relevant bibliographies by topics / Cellule tumorali K-ras

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Academic literature on the topic 'Cellule tumorali K-ras'

Author: Grafiati

Published: 9 March 2023

Last updated: 10 March 2023

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Journal articles on the topic "Cellule tumorali K-ras"

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Morioka, C. Y., F. P. Costa, S. Saito, E. M. Lima, A. Watanabe, and C. C. Huang. "Can antisense oligonucleotides targeted K-ras gene downregulate the expression of MMP-2 and MMP-9 in orthotopically implanted pancreatic cancer in Syrian golden hamsters." Journal of Clinical Oncology 25, no. 18_suppl (2007): 14147. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.14147.

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14147 Background: Matrix metalloproteinases (MMP), especially MMP-2 and MMP-9, are thought to play major roles in pancreatic cancer growth and metastasis.Ras activates a multitude of downstream activities with roles in cellular processing, including invasion and metastasis.Therefore, antisense oligonucleotides (ASO) targeting K-ras gene may be a therapeutic approach. Aim: To elucidate the effectiveness of this gene therapy in growth, invasiveness,and expression of MMPs,in hamster experimental pancreatic cancer model. Materials and Methods: HaP-T1,a cell line derived from BHP-induced pancreatic

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Molina, Jennifer R., Joseph M. Gozgit, Melissa M. Vasbinder, et al. "Abstract 2154: PARP7 inhibitor RBN-2397 increases tumoral IFN signaling leading to various tumor cell intrinsic effects and tumor regressions in mouse models." Cancer Research 82, no. 12_Supplement (2022): 2154. http://dx.doi.org/10.1158/1538-7445.am2022-2154.

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Abstract Targeting cytosolic nucleic acid sensing pathways to activate the Type I interferon (IFN) response is an emerging therapeutic strategy being explored in oncology. The PARP family consists of seventeen enzymes that regulate fundamental biological processes including response to cellular stress. PARP7 (TIPARP) is a stress-induced mono-ART that catalyzes the transfer of a single unit of ADP-ribose onto substrates (MARylation) to regulate their function and plays a role in suppressing the Type I IFN response in tumor cells (Gozgit 2021 Cancer Cell). RBN-2397 is the first potent and select

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Dissertations / Theses on the topic "Cellule tumorali K-ras"

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PALORINI, ROBERTA. "K-ras cancer cell fate under glucose deprivation is influenced by alteration of bioenergetic metabolism." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2013. http://hdl.handle.net/10281/41975.

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Molte cellule tumorali, al fine di generare ATP e sostenere i processi anabolici, si servono principalmente della glicolisi piuttosto che della respirazione mitocondriale. Di conseguenza, il glucosio assume un ruolo critico per la sopravvivenza e la proliferazione delle cellule tumorali. Inoltre, attraverso la via dei pentosi fosfati, il glucosio porta alla formazione di NADPH, contribuendo al mantenimento nelle cellule dell’equilibrio ossidativo. Nondimeno, il glucosio può entrare anche nel pathway biosintetico delle esosammine (HBP), sostenendo la N- e O-glicosilazione di lipidi e proteine,

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Chirica, Mircea. "Analyse de la réponse immunitaire anti-tumorale selon les caractéristiques oncogénétiques du cancer colorectal." Sorbonne Paris Cité, 2015. http://www.theses.fr/2015USPCC082.

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Les cancers colorectaux (CCR) se développent en face d'un système immunitaire important associé à la muqueuse intestinale. Les avancées récentes en immunologie tumorale ont mis en évidence le rôle de la réponse immunitaire dans le développement, l'évolution et le pronostic des cancers. Le système immunitaire est capable de modifier activement les cellules précancéreuses à fur et à mesure qu'elles apparaissent dans les tissus. La qualité de la réponse immunitaire contre la tumeur est un facteur pronostique important chez les patients atteints de CCR. Différents types de mutations génétiques imp

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Regina, Sandra. "Expression du facteur tissulaire dans le cancer bronchique non à petites cellules : relation avec l'angiogenèse tumorale et les mutations des gènes K-RAS, p53, PTEN ET LKB1." Thesis, Tours, 2008. http://www.theses.fr/2008TOUR3115.

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Le facteur tissulaire (FT), protéine centrale de la coagulation plasmatique, joue un rôle direct dans le développement tumoral. Nous avons étudié l’expression génique et protéique du FT dans des échantillons de cancer bronchique non à petites cellules (CBNPC) et avons recherché une relation entre le niveau d’expression du FT, l’angiogénèse tumorale, les mutations de K- RAS, p53, PTEN et LKB1 et l’expression de l’héparanase. Nos résultats montrent que l’expression de FT est plus importante dans les tumeurs de grande taille et dans les stades avancés. Aucune relation n’a été retrouvée entre l’ex

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