Relevant bibliographies by topics / Cellules DN T

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  1. Journal articles
  2. Dissertations / Theses

Academic literature on the topic 'Cellules DN T'

Author: Grafiati
Published: 4 June 2021
Last updated: 2 February 2022

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Journal articles on the topic "Cellules DN T"

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Haug, Tabea, Heiko Bruns, Michael Aigner, Andreas Mackensen, and Simon Voelkl. "Human Double-Negative Regulatory T Cells Selectively Suppress mTOR Signaling and Metabolic Reprogramming of Conventional T Cells." Blood 128, no. 22 (2016): 3694. http://dx.doi.org/10.1182/blood.v128.22.3694.3694.

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Abstract Regulatory T (Treg) cells have been shown to be involved in downregulating immune responses in autoimmunity, transplant rejection, and graft-versus-host disease (GvHD). The subpopulation of TCRαβ+ CD4- CD8- (double-negative, DN) T cells has been described to suppress immune responses in both mice and humans. Of particular interest, infusion and/or activation of murine DN T cells specifically suppressed alloreactive T cells and prevented development of GvHD after allogeneic hematopoietic stem cell transplantation (SCT). Moreover, clinical studies in patients after SCT revealed an inver
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Tu, Cheng-Wei, Fang-Chang Tsai, Jem-Kun Chen, et al. "Preparations of Tough and Conductive PAMPS/PAA Double Network Hydrogels Containing Cellulose Nanofibers and Polypyrroles." Polymers 12, no. 12 (2020): 2835. http://dx.doi.org/10.3390/polym12122835.

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To afford an intact double network (sample abbr.: DN) hydrogel, two-step crosslinking reactions of poly(2-acrylamido-2-methylpropanesulfonic acid) (i.e., PAMPS first network) and then poly(acrylic acid) (i.e., PAA second network) were conducted both in the presence of crosslinker (N,N′-methylenebisacrylamide (MBAA)). Similar to the two-step processes, different contents of 2,2,6,6-tetramethyl-1-piperidinyloxy (TEMPO) oxidized cellulose nanofibers (TOCN: 1, 2, and 3 wt.%) were initially dispersed in the first network solutions and then crosslinked. The TOCN-containing PAMPS first networks subse
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Haug, Tabea, Michael Aigner, Heiko Bruns, et al. "Human Double-Negative Regulatory T Cells Modulate Effector Functions of Conventional T Cells By Selectively Blocking mTOR Signaling." Blood 132, Supplement 1 (2018): 2410. http://dx.doi.org/10.1182/blood-2018-99-112943.

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Abstract Regulatory T cells play an important role in the maintenance of immune tolerance to self-antigens and are involved in modulating immune responses to promote resolution of inflammation. The population of TCRαβ+ CD4-/CD8- (double-negative, DN) T cells has attracted growing attention as a result of their potent immune regulatory function. In murine models, DN T cells were able to prevent rejection of allogeneic and xenogeneic organ grafts by effectively suppressing reactive T cells. In addition, DN T cells possess the capacity to resolve various inflammatory conditions, including graft-v
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Antonelli, Lis R. V., Walderez O. Dutra, Ricardo R. Oliveira та ін. "Disparate Immunoregulatory Potentials for Double-Negative (CD4− CD8−) αβ and γδ T Cells from Human Patients with Cutaneous Leishmaniasis". Infection and Immunity 74, № 11 (2006): 6317–23. http://dx.doi.org/10.1128/iai.00890-06.

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ABSTRACT Although most T lymphocytes express the αβ T-cell receptor and either CD4 or CD8 molecules, a small population of cells lacking these coreceptors, CD4− CD8− (double negative [DN]) T cells, has been identified in the peripheral immune system of mice and humans. To better understand the role that this population may have in the human immune response against Leishmania spp., a detailed study defining the activation state, cytokine profile, and the heterogeneity of DN T cells bearing αβ or γδ T-cell receptors was performed with a group of well-defined cutaneous leishmaniasis patients. Str
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Herrera, Marcela, Magnus Söderberg, Alan Sabirsh, et al. "Inhibition of T-cell activation by the CTLA4-Fc Abatacept is sufficient to ameliorate proteinuric kidney disease." American Journal of Physiology-Renal Physiology 312, no. 4 (2017): F748—F759. http://dx.doi.org/10.1152/ajprenal.00179.2016.

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Diabetic nephropathy (DN) remains an unmet medical challenge as its prevalence is projected to continue to increase and specific medicines for treatment remain undeveloped. Activation of the immune system, in particular T-cells, is emerging as a possible mechanism underlying DN disease progression in humans and animal models. We hypothesized that inhibition of T-cell activation will ameliorate DN. Interaction of B7-1 (CD80) on the surface of antigen presenting cells with its binding partners, CTLA4 (CD152) and CD28 on T-cells, is essential for T-cell activation. In this study we used the solub
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Voelkl, Simon, Regina Gary та Andreas Mackensen. "Characterization of the Immunoregulatory Function of Human TCRαβ+ CD4-CD8- Double-Negative T Cells". Blood 116, № 21 (2010): 2776. http://dx.doi.org/10.1182/blood.v116.21.2776.2776.

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Abstract Abstract 2776 Regulatory T (Treg) cells have been shown to be involved in downregulating immune responses in autoimmunity, transplant rejection, and graft-versus-host disease. Moreover, the important role of Treg cells in tumor progression has also been extensively investigated and Treg-mediated immune suppression has emerged as a crucial mechanism of tumor evasion. Recently, a novel subset of TCRαβ+ CD4−CD8− (double-negative, DN) T cells has been characterized to specifically suppress immune responses in mice. Here we demonstrate that human DN T cells belong to the family of inducibl
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7

Peuser, Moritz, Tabea Haug, Michael Aigner, Andreas Mackensen, and Simon Voelkl. "Effect of Proinflammatory and Homeostatic Cytokines on the Functionality of Human Double-Negative Regulatory T Cells." Blood 132, Supplement 1 (2018): 3726. http://dx.doi.org/10.1182/blood-2018-99-112977.

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Abstract Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is often the only curative treatment option for patients with hematologic malignancies. Its therapeutic effect is mediated by donor T cells, recognizing and eliminating residual malignant cells of the patient. However, the main adverse effect of allo-HSCT is also mediated by these T cells: the so-called graft-versus-host disease (GvHD). A promising approach to treat GvHD is the use of immunosuppressive T cell populations to inhibit uncontrolled T cell activation. A novel regulatory T cell population described in the settin
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Foskett, Shannon M., Romi Ghose, Derek Ng Tang, Dorothy E. Lewis, and Andrew P. Rice. "Antiapoptotic Function of Cdk9 (TAK/P-TEFb) in U937 Promonocytic Cells." Journal of Virology 75, no. 3 (2001): 1220–28. http://dx.doi.org/10.1128/jvi.75.3.1220-1228.2001.

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ABSTRACT Cdk9 is the catalytic subunit of TAK (cyclinT1/P-TEFb), a cellular protein kinase that mediates human immunodeficiency virus type 1 (HIV-1) Tat transcriptional activation function. To examine Cdk9 function in cells relevant to HIV-1 infection, we used a murine leukemia virus retrovirus vector to transduce and overexpress the cDNA of a dominant negative mutant Cdk9 protein (Cdk9-dn) in Jurkat T cells and U937 promonocytic cells. In Jurkat cells, overexpression of Cdk9-dn specifically inhibited Tat transactivation and HIV-1 replication but had no inhibitory effect on induction of CD69,
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Lin, Kui, Nancy S. Longo, Xin Wang, Judy A. Hewitt та Kristin M. Abraham. "Lck Domains Differentially Contribute to Pre–T Cell Receptor (Tcr)–And TCR-α/β–Regulated Developmental Transitions". Journal of Experimental Medicine 191, № 4 (2000): 703–16. http://dx.doi.org/10.1084/jem.191.4.703.

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Maturational changes at the CD4−CD8− double negative (DN) to CD4+CD8+ double positive (DP) transition are dependent on signals generated via the pre–T cell receptor (TCR) and the nonreceptor protein tyrosine kinase p56lck (Lck). How Lck activities are stimulated or relayed after pre-TCR formation remains obscure. Our structure–function mapping of Lck thymopoietic properties reveals that the noncatalytic domains of Lck are specialized to signal efficient cellular expansion at DN to DP transition. Moreover, although substitution of the Lck catalytic domain with FynT sequences minimally impacts D
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Lin, Jian-Xin, Rosanne Spolski, and Warren J. Leonard. "Critical role for Rsk2 in T-lymphocyte activation." Blood 111, no. 2 (2008): 525–33. http://dx.doi.org/10.1182/blood-2007-02-072207.

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During T-cell activation, a number of cytokine-activated signaling cascades, including the Jak-STAT, phosphoinositol 3-kinase (PI 3-kinase), and mitogen-activated protein kinase (MAPK) pathways, play important roles in modulating the expression of target genes and mediating a cellular response. We now report that interleukin 2 (IL-2) and IL-15, but not IL-7, rapidly activate the p90 ribosomal S6 kinases, Rsk1 and Rsk2, in human T lymphocytes. Surprisingly, mouse spleen T cells transduced with either the wild-type or a dominant-negative (DN) Rsk2-expressing retrovirus could not be recovered, in
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Dissertations / Theses on the topic "Cellules DN T"

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Boulos, Sandra. "Étude des fonctions immunomodulatrices des lymphocytes T « Doubles-Négatifs »." Thèse, 2011. http://hdl.handle.net/1866/6095.

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La réaction du greffon contre l’hôte (GvH) est responsable d’un grand taux de morbidité et de mortalité chez les patients recevant des greffes de cellules souches (GCSH) allogéniques. Dans ce contexte, les cellules T régulatrices sont largement étudiées et semblent avoir un grand potentiel d’utilisation dans le domaine de la thérapie cellulaire de la GvH. Parmi les populations cellulaires T régulatrices, les lymphocytes T CD4-CD8- TCRαβ+ « Doubles-Négatifs » (DN), qui ne représentent que 1-3% des lymphocytes T, ont été décrits. Ces cellules ont des propriétés inhibitrices de la réponse immunit
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Collin, Roxanne. "Immunogénétique et développement des lymphocytes T CD4-CD8- immunorégulateurs chez la souris." Thèse, 2018. http://hdl.handle.net/1866/21851.

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