Academic literature on the topic 'Cementum Protein 1 (CEMP1)'

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Journal articles on the topic "Cementum Protein 1 (CEMP1)"

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Santana, Maricela, Gonzalo Montoya, Raúl Herrera, et al. "Cemp1-p3 Peptide Promotes the Transformation of Octacalcium Phosphate into Hydroxyapatite Crystals." Crystals 10, no. 12 (2020): 1131. http://dx.doi.org/10.3390/cryst10121131.

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Dental cementum contains unique molecules that regulate the mineralization process in vitro and in vivo, such as cementum protein 1 (CEMP1). This protein possesses amino acid sequence motifs like the human recombinant CEMP1 with biological activity. This novel cementum protein 1-derived peptide (CEMP1-p3, from the CEMP1’s N-terminal domain: (QPLPKGCAAVKAEVGIPAPH), consists of 20 amino acids. Hydroxyapatite (HA) crystals could be obtained through the combination of the amorphous precursor phase and macromolecules such as proteins and peptides. We used a simple method to synthesize peptide/hydro
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Arroyo, Rita, Sonia López, Enrique Romo та ін. "Carboxy-Terminal Cementum Protein 1-Derived Peptide 4 (cemp1-p4) Promotes Mineralization through wnt/β-catenin Signaling in Human Oral Mucosa Stem Cells". International Journal of Molecular Sciences 21, № 4 (2020): 1307. http://dx.doi.org/10.3390/ijms21041307.

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Human cementum protein 1 (CEMP1) is known to induce cementoblast and osteoblast differentiation and alkaline phosphatase (ALP) activity in human periodontal ligament-derived cells in vitro and promotes bone regeneration in vivo. CEMP1′s secondary structure analysis shows that it has a random-coiled structure and is considered an Intrinsic Disordered Protein (IDP). CEMP1′s short peptide sequences mimic the biological capabilities of CEMP1. However, the role and mechanisms of CEMP1′s C-terminal-derived synthetic peptide (CEMP1-p4) in the canonical Wnt/β-catenin signaling pathway are yet to be de
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Yasunaga, Madoka, Hiroyuki Ishikawa, Sachio Tamaoki, Hidefumi Maeda, and Jun Ohno. "Embedded Human Periodontal Ligament Stem Cells Spheroids Enhance Cementogenic Differentiation via Plasminogen Activator Inhibitor 1." International Journal of Molecular Sciences 23, no. 4 (2022): 2340. http://dx.doi.org/10.3390/ijms23042340.

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Spheroids reproduce the tissue structure that is found in vivo more accurately than classic two-dimensional (2D) monolayer cultures. We cultured human periodontal ligament stem cells (HPLSCs) as spheroids that were embedded in collagen gel to examine whether their cementogenic differentiation could be enhanced by treatment with recombinant human plasminogen activator inhibitor-1 (rhPAI-1). The upregulated expression of cementum protein 1 (CEMP1) and cementum attachment protein (CAP), established cementoblast markers, was observed in the 2D monolayer HPLSCs that were treated with rhPAI-1 for 3
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Bourdon, Laura, Nina Attik, Liza Belkessam, et al. "Direct-Writing Electrospun Functionalized Scaffolds for Periodontal Regeneration: In Vitro Studies." Journal of Functional Biomaterials 14, no. 5 (2023): 263. http://dx.doi.org/10.3390/jfb14050263.

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Multiphasic scaffolds that combine different architectural, physical, and biological properties are the best option for the regeneration of complex tissues such as the periodontium. Current developed scaffolds generally lack architectural accuracy and rely on multistep manufacturing, which is difficult to implement for clinical applications. In this context, direct-writing electrospinning (DWE) represents a promising and rapid technique for developing thin 3D scaffolds with controlled architecture. The current study aimed to elaborate a biphasic scaffold using DWE based on two polycaprolactone
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Serrano, Janeth, Enrique Romo, Mercedes Bermúdez, et al. "Bone Regeneration in Rat Cranium Critical-Size Defects Induced by Cementum Protein 1 (CEMP1)." PLoS ONE 8, no. 11 (2013): e78807. http://dx.doi.org/10.1371/journal.pone.0078807.

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Tian, Zhiwei, Zhongqi Zhao, Marco Aoqi Rausch, et al. "Potential of Trilayered Gelatin/Polycaprolactone Nanofibers for Periodontal Regeneration: An In Vitro Study." International Journal of Molecular Sciences 26, no. 2 (2025): 672. https://doi.org/10.3390/ijms26020672.

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Over the past few years, biomaterial-based periodontal tissue engineering has gained popularity. An ideal biomaterial for treating periodontal defects is expected to stimulate periodontal-derived cells, allowing them to contribute most efficiently to tissue reconstruction. The present study focuses on evaluating the in vitro behavior of human periodontal ligament-derived stromal cells (hPDL-MSCs) when cultured on gelatin/Polycaprolactone prototype (GPP) and volume-stable collagen matrix (VSCM). Cells were cultured onto the GPP, VSCM, or tissue culture plate (TCP) for 3, 7, and 14 days. Cell mo
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Hoz, Lía, Enrique Romo, Margarita Zeichner‑David, et al. "Cementum protein 1 (CEMP1) induces differentiation by human periodontal ligament cells under three-dimensional culture conditions." Cell Biology International 36, no. 2 (2011): 129–36. http://dx.doi.org/10.1042/cbi20110168.

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Komaki, Motohiro, Kengo Iwasaki, Higinio Arzate, A. Sampath Narayanan, Yuichi Izumi, and Ikuo Morita. "Cementum protein 1 (CEMP1) induces a cementoblastic phenotype and reduces osteoblastic differentiation in periodontal ligament cells." Journal of Cellular Physiology 227, no. 2 (2011): 649–57. http://dx.doi.org/10.1002/jcp.22770.

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Bakr, Mahmoud M., Mahmoud Al Ankily, Mohammed Meer, and Mohamed Shamel. "Comparative Analysis of Gene Expression in Periodontal Ligament Stem Cells Exposed to Biodentine and Bio-C Repair: Implications for Cementogenesis—An In Vitro Study." Oral 5, no. 1 (2025): 19. https://doi.org/10.3390/oral5010019.

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Background/Objectives: Bioactive materials are gaining increased popularity as materials of choice for pulpal regeneration. A similar trend is emerging with root repair materials; however, there is a significant gap in the literature about cementogenic ability of bioceramic repair materials on the periodontal ligament cells. The aim of the present study was to investigate the effect of bioceramic materials (Biodentine and Bio-C Repair) on the cementogenesis potential of the periodontal ligament stem cells (PDLSCs). Methods: PDLSCs were isolated using the enzymatic digestion approach from sound
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Wang, Qing-qing, Siqing Wang, Tian Zhao, et al. "Biomimetic oligopeptide formed enamel-like tissue and dentin tubule occlusion via mineralization for dentin hypersensitivity treatment." Journal of Applied Biomaterials & Functional Materials 19 (January 2021): 228080002110053. http://dx.doi.org/10.1177/22808000211005384.

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Objective: Dentin hypersensitivity (DH) is a common oral disease with approximately 41.9% prevalence. Reconstruction of dental hard tissues is the preferred treatment for relieving DH. Here, we applied biomineralization method using oligopeptide simulating cementum protein 1 (CEMP1) to regenerate hard tissues on demineralized dentin. Methods: The self-assembly and biomineralization property of the oligopeptide were detected by scanning electron microscopy (SEM), circular dichroism spectroscopy, and transmission electron microscopy. Oligopeptide’s binding capacity to demineralized dentin was ev
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Conference papers on the topic "Cementum Protein 1 (CEMP1)"

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Liu, Yu, and Weibin Sun. "Construction of a Eukaryotic Expression Vector of Human Cementum Protein 1 and Its Stably Expression in NIH3T3 Cell." In 2010 4th International Conference on Bioinformatics and Biomedical Engineering (iCBBE). IEEE, 2010. http://dx.doi.org/10.1109/icbbe.2010.5516906.

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