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Journal articles on the topic 'Cementum Protein 1 (CEMP1)'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Santana, Maricela, Gonzalo Montoya, Raúl Herrera, et al. "Cemp1-p3 Peptide Promotes the Transformation of Octacalcium Phosphate into Hydroxyapatite Crystals." Crystals 10, no. 12 (2020): 1131. http://dx.doi.org/10.3390/cryst10121131.

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Dental cementum contains unique molecules that regulate the mineralization process in vitro and in vivo, such as cementum protein 1 (CEMP1). This protein possesses amino acid sequence motifs like the human recombinant CEMP1 with biological activity. This novel cementum protein 1-derived peptide (CEMP1-p3, from the CEMP1’s N-terminal domain: (QPLPKGCAAVKAEVGIPAPH), consists of 20 amino acids. Hydroxyapatite (HA) crystals could be obtained through the combination of the amorphous precursor phase and macromolecules such as proteins and peptides. We used a simple method to synthesize peptide/hydro

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Arroyo, Rita, Sonia López, Enrique Romo та ін. "Carboxy-Terminal Cementum Protein 1-Derived Peptide 4 (cemp1-p4) Promotes Mineralization through wnt/β-catenin Signaling in Human Oral Mucosa Stem Cells". International Journal of Molecular Sciences 21, № 4 (2020): 1307. http://dx.doi.org/10.3390/ijms21041307.

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Human cementum protein 1 (CEMP1) is known to induce cementoblast and osteoblast differentiation and alkaline phosphatase (ALP) activity in human periodontal ligament-derived cells in vitro and promotes bone regeneration in vivo. CEMP1′s secondary structure analysis shows that it has a random-coiled structure and is considered an Intrinsic Disordered Protein (IDP). CEMP1′s short peptide sequences mimic the biological capabilities of CEMP1. However, the role and mechanisms of CEMP1′s C-terminal-derived synthetic peptide (CEMP1-p4) in the canonical Wnt/β-catenin signaling pathway are yet to be de

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Yasunaga, Madoka, Hiroyuki Ishikawa, Sachio Tamaoki, Hidefumi Maeda, and Jun Ohno. "Embedded Human Periodontal Ligament Stem Cells Spheroids Enhance Cementogenic Differentiation via Plasminogen Activator Inhibitor 1." International Journal of Molecular Sciences 23, no. 4 (2022): 2340. http://dx.doi.org/10.3390/ijms23042340.

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Spheroids reproduce the tissue structure that is found in vivo more accurately than classic two-dimensional (2D) monolayer cultures. We cultured human periodontal ligament stem cells (HPLSCs) as spheroids that were embedded in collagen gel to examine whether their cementogenic differentiation could be enhanced by treatment with recombinant human plasminogen activator inhibitor-1 (rhPAI-1). The upregulated expression of cementum protein 1 (CEMP1) and cementum attachment protein (CAP), established cementoblast markers, was observed in the 2D monolayer HPLSCs that were treated with rhPAI-1 for 3

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Bourdon, Laura, Nina Attik, Liza Belkessam, et al. "Direct-Writing Electrospun Functionalized Scaffolds for Periodontal Regeneration: In Vitro Studies." Journal of Functional Biomaterials 14, no. 5 (2023): 263. http://dx.doi.org/10.3390/jfb14050263.

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Multiphasic scaffolds that combine different architectural, physical, and biological properties are the best option for the regeneration of complex tissues such as the periodontium. Current developed scaffolds generally lack architectural accuracy and rely on multistep manufacturing, which is difficult to implement for clinical applications. In this context, direct-writing electrospinning (DWE) represents a promising and rapid technique for developing thin 3D scaffolds with controlled architecture. The current study aimed to elaborate a biphasic scaffold using DWE based on two polycaprolactone

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Serrano, Janeth, Enrique Romo, Mercedes Bermúdez, et al. "Bone Regeneration in Rat Cranium Critical-Size Defects Induced by Cementum Protein 1 (CEMP1)." PLoS ONE 8, no. 11 (2013): e78807. http://dx.doi.org/10.1371/journal.pone.0078807.

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6

Tian, Zhiwei, Zhongqi Zhao, Marco Aoqi Rausch, et al. "Potential of Trilayered Gelatin/Polycaprolactone Nanofibers for Periodontal Regeneration: An In Vitro Study." International Journal of Molecular Sciences 26, no. 2 (2025): 672. https://doi.org/10.3390/ijms26020672.

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Over the past few years, biomaterial-based periodontal tissue engineering has gained popularity. An ideal biomaterial for treating periodontal defects is expected to stimulate periodontal-derived cells, allowing them to contribute most efficiently to tissue reconstruction. The present study focuses on evaluating the in vitro behavior of human periodontal ligament-derived stromal cells (hPDL-MSCs) when cultured on gelatin/Polycaprolactone prototype (GPP) and volume-stable collagen matrix (VSCM). Cells were cultured onto the GPP, VSCM, or tissue culture plate (TCP) for 3, 7, and 14 days. Cell mo

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Hoz, Lía, Enrique Romo, Margarita Zeichner‑David, et al. "Cementum protein 1 (CEMP1) induces differentiation by human periodontal ligament cells under three-dimensional culture conditions." Cell Biology International 36, no. 2 (2011): 129–36. http://dx.doi.org/10.1042/cbi20110168.

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Komaki, Motohiro, Kengo Iwasaki, Higinio Arzate, A. Sampath Narayanan, Yuichi Izumi, and Ikuo Morita. "Cementum protein 1 (CEMP1) induces a cementoblastic phenotype and reduces osteoblastic differentiation in periodontal ligament cells." Journal of Cellular Physiology 227, no. 2 (2011): 649–57. http://dx.doi.org/10.1002/jcp.22770.

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9

Bakr, Mahmoud M., Mahmoud Al Ankily, Mohammed Meer, and Mohamed Shamel. "Comparative Analysis of Gene Expression in Periodontal Ligament Stem Cells Exposed to Biodentine and Bio-C Repair: Implications for Cementogenesis—An In Vitro Study." Oral 5, no. 1 (2025): 19. https://doi.org/10.3390/oral5010019.

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Background/Objectives: Bioactive materials are gaining increased popularity as materials of choice for pulpal regeneration. A similar trend is emerging with root repair materials; however, there is a significant gap in the literature about cementogenic ability of bioceramic repair materials on the periodontal ligament cells. The aim of the present study was to investigate the effect of bioceramic materials (Biodentine and Bio-C Repair) on the cementogenesis potential of the periodontal ligament stem cells (PDLSCs). Methods: PDLSCs were isolated using the enzymatic digestion approach from sound

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10

Wang, Qing-qing, Siqing Wang, Tian Zhao, et al. "Biomimetic oligopeptide formed enamel-like tissue and dentin tubule occlusion via mineralization for dentin hypersensitivity treatment." Journal of Applied Biomaterials & Functional Materials 19 (January 2021): 228080002110053. http://dx.doi.org/10.1177/22808000211005384.

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Objective: Dentin hypersensitivity (DH) is a common oral disease with approximately 41.9% prevalence. Reconstruction of dental hard tissues is the preferred treatment for relieving DH. Here, we applied biomineralization method using oligopeptide simulating cementum protein 1 (CEMP1) to regenerate hard tissues on demineralized dentin. Methods: The self-assembly and biomineralization property of the oligopeptide were detected by scanning electron microscopy (SEM), circular dichroism spectroscopy, and transmission electron microscopy. Oligopeptide’s binding capacity to demineralized dentin was ev

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Liu, Jin, Quan Dai, Michael D. Weir, et al. "Biocompatible Nanocomposite Enhanced Osteogenic and Cementogenic Differentiation of Periodontal Ligament Stem Cells In Vitro for Periodontal Regeneration." Materials 13, no. 21 (2020): 4951. http://dx.doi.org/10.3390/ma13214951.

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Decays in the roots of teeth is prevalent in seniors as people live longer and retain more of their teeth to an old age, especially in patients with periodontal disease and gingival recession. The objectives of this study were to develop a biocompatible nanocomposite with nano-sized calcium fluoride particles (Nano-CaF2), and to investigate for the first time the effects on osteogenic and cementogenic induction of periodontal ligament stem cells (hPDLSCs) from human donors.Nano-CaF2 particles with a mean particle size of 53 nm were produced via a spray-drying machine.Nano-CaF2 was mingled into

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Astuty, Syanti Wahyu, Hari Sunarto, Lisa Amir, and Erik Idrus. "EVALUATION OF REGENERATIVE THERAPY USING CELL SHEET THROUGH CEMENTUM PROTEIN-1 EXPRESSION ON MACACA NEMESTRINA." International Journal of Applied Pharmaceutics 9 (January 1, 2018): 107. http://dx.doi.org/10.22159/ijap.2017.v9s2.26.

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Objective: The main objective of periodontal therapy is tissue regeneration. Previous studies have identified the potential of mesenchymal stem cells to improve major periodontal defect reconstruction in bone tissue engineering. Cell sheet technology (CST), in which a cell culture is obtained from a material coated with a temperature-sensitive substrate, has been developed for the reconstruction of various tissues, including periodontal tissue. Cementum protein-1 (CEMP-1) is a 50-kDa protein that plays a crucial role in cementogenesis by enhancing the combining of cells formed by cell cementob

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Dellavia, Claudia, Elena Canciani, Giulio Rasperini, Giorgio Pagni, Matteo Malvezzi, and Gaia Pellegrini. "CEMP-1 Levels in Periodontal Wound Fluid during the Early Phase of Healing: Prospective Clinical Trial." Mediators of Inflammation 2019 (February 24, 2019): 1–8. http://dx.doi.org/10.1155/2019/1737306.

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Objectives. Cementogenesis seems to be significantly compromised during tissue inflammation. In dental practice, surgical procedures are performed with the aim to regenerate periodontium including cementum. However, inflammation that occurs during the initial healing phases after surgery may impair regeneration of this tissues. The aim of the present study was to assess if surgical procedures designed to regenerate periodontium might affect levels of cementum protein-1 (CEMP-1) in periodontal wound fluid during early phase of healing. Materials and Methods. In 36 patients, 18 intrabony periodo

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Lopez-Ayuso, Christian Andrea, Benjamin Aranda-Herrera, Dulce Guzman-Rocha, Patricia Alejandra Chavez-Granados, and Rene Garcia-Contreras. "Synthetic Proteins in Dental Applications." SynBio 2, no. 1 (2023): 1–20. http://dx.doi.org/10.3390/synbio2010001.

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Biotechnology and artificial intelligence have sparked a revolution in dentistry, with a focus on restoring natural tissue functions. This transformation has given rise to bioactive materials, inspired by biomimetics, aimed at replicating the processes found in nature. As synthetic biology advances, there is a heightened focus on signaling systems crucial for bio-based diagnostics and therapeutics. Dentistry now harnesses synthetic proteins for tissue regeneration and dental material enhancement. A current research priority is bacterial biofilm inhibition, vital for dental health. Given the ro

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Amir, Lisa R., Yuniarti Soeroso, Dewi Fatma, et al. "Periodontal Ligament Cell Sheets and RGD-Modified Chitosan Improved Regeneration in the Horizontal Periodontal Defect Model." European Journal of Dentistry 14, no. 02 (2020): 306–14. http://dx.doi.org/10.1055/s-0040-1709955.

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Abstract Objective The aim of this study was to examine the potential of periodontal ligament (PDL) cells sheet and arginine-glycyl-aspartic acid (RGD)-modified chitosan scaffold for periodontal tissue regeneration in horizontal periodontal defect model. Materials and Methods PDL cell cytotoxicity was tested with 3–[4,5- dimethylthiazol-2yl]–2,5-diphenyl-2H-tetrazolium bromide assay. Cell migration toward the chitosan-based materials was analyzed with trans-well migration assay. Horizontal periodontal defect model was created in four maxillary and mandibular lateral incisors of Macaque nemestr

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Hussein, Nancy, Josephine Meade, Hemant Pandit, Elena Jones, and Reem El-Gendy. "Characterisation and Expression of Osteogenic and Periodontal Markers of Bone Marrow Mesenchymal Stem Cells (BM-MSCs) from Diabetic Knee Joints." International Journal of Molecular Sciences 25, no. 5 (2024): 2851. http://dx.doi.org/10.3390/ijms25052851.

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Type 2 diabetes mellitus (T2DM) represents a significant health problem globally and is linked to a number of complications such as cardiovascular disease, bone fragility and periodontitis. Autologous bone marrow mesenchymal stem cells (BM-MSCs) are a promising therapeutic approach for bone and periodontal regeneration; however, the effect of T2DM on the expression of osteogenic and periodontal markers in BM-MSCs is not fully established. Furthermore, the effect of the presence of comorbidities such as diabetes and osteoarthritis on BM-MSCs is also yet to be investigated. In the present study,

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Sun, Weibin, Yu Liu, Leiying Miao, et al. "Controlled release of recombinant human cementum protein 1 from electrospun multiphasic scaffold for cementum regeneration." International Journal of Nanomedicine Volume 11 (July 2016): 3145–58. http://dx.doi.org/10.2147/ijn.s104324.

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18

Carmona-Rodríguez, Bruno, Marco Antonio Álvarez-Pérez, A. Sampath Narayanan, et al. "Human Cementum Protein 1 induces expression of bone and cementum proteins by human gingival fibroblasts." Biochemical and Biophysical Research Communications 358, no. 3 (2007): 763–69. http://dx.doi.org/10.1016/j.bbrc.2007.04.204.

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Ye, L., S. Zhang, H. Ke, L. F. Bonewald, and JQ Feng. "Periodontal Breakdown in the Dmp1 Null Mouse Model of Hypophosphatemic Rickets." Journal of Dental Research 87, no. 7 (2008): 624–29. http://dx.doi.org/10.1177/154405910808700708.

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Dentin Matrix Protein 1 (DMP1) is highly expressed in alveolar bone and cementum, which are important components of the periodontium. Therefore, we hypothesized that Dmp1 is critical for the integrity of the periodontium, and that deletion may lead to increased susceptibility to disease. An early-onset periodontal defect was observed in the Dmp1 null mouse, a mouse model of hypophosphatemic rickets. The alveolar bone is porous, with increased proteoglycan expression. The cementum is also defective, as characterized by irregular, punctate fluorochrome labeling and elevated proteoglycan. The ost

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Villarreal-Ramírez, Eduardo, Abel Moreno, Jaime Mas-Oliva, et al. "Characterization of recombinant human cementum protein 1 (hrCEMP1): Primary role in biomineralization." Biochemical and Biophysical Research Communications 384, no. 1 (2009): 49–54. http://dx.doi.org/10.1016/j.bbrc.2009.04.072.

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Ripamonti, Ugo, and A. Hari Reddi. "Tissue Engineering, Morphogenesis, and Regeneration of the Periodontal Tissues By Bone Morphogenetic Proteins." Critical Reviews in Oral Biology & Medicine 8, no. 2 (1997): 154–63. http://dx.doi.org/10.1177/10454411970080020401.

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Tissue engineering is the emerging field of science developing techniques for fabrication of new tissues for replacement based on principles of cell and developmental biology and biomaterials. Morphogenesis is the cascade of pattern formation and the attainment of form of the various organs and the organism as a whole. The periodontium consists of the periodontal ligament, cementum, and alveolar bone. Bone has considerable potential for regeneration and therefore is a prototypic model for tissue engineering. The three main ingredients for tissue engineering are regulatory signals, responding s

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Zhang, H., M. B. Chavez, T. N. Kolli, et al. "Dentoalveolar Defects in the Hyp Mouse Model of X-linked Hypophosphatemia." Journal of Dental Research 99, no. 4 (2020): 419–28. http://dx.doi.org/10.1177/0022034520901719.

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Mutations in PHEX cause X-linked hypophosphatemia (XLH), a form of hypophosphatemic rickets. Hyp ( Phex mutant) mice recapitulate the XLH phenotype. Dental disorders are prevalent in individuals with XLH; however, underlying dentoalveolar defects remain incompletely understood. We analyzed Hyp mouse dentoalveolar defects at 42 and 90 d postnatal to comparatively define effects of XLH on dental formation and function. Phex mRNA was expressed by odontoblasts (dentin), osteocytes (bone), and cementocytes (cellular cementum) in wild-type (WT) mice. Enamel density was unaffected, though enamel volu

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Sawada, T., T. Ishikawa, S. Shintani, and T. Yanagisawa. "Ultrastructural immunolocalization of dentin matrix protein 1 on Sharpey's fibers in monkey tooth cementum." Biotechnic & Histochemistry 87, no. 5 (2012): 360–65. http://dx.doi.org/10.3109/10520295.2012.671493.

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Zairi, Anna, Theodoros Lambrianidis, Ourania Pantelidou, Serafim Papadimitriou, and Dimitrios Tziafas. "Periradicular Tissue Responses to Biologically Active Molecules or MTA When Applied in Furcal Perforation of Dogs' Teeth." International Journal of Dentistry 2012 (2012): 1–9. http://dx.doi.org/10.1155/2012/257832.

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The aim of this study was the comparative evaluation of inflammatory reactions and tissue responses to four growth factors, or mineral trioxide aggregate (MTA), or a zinc-oxide-eugenol-based cement (IRM) as controls, when used for the repair of furcal perforations in dogs’ teeth. Results showed significantly higher inflammatory cell response in the transforming growth factorβ1 (TGFβ1) and zinc-oxide-eugenol-based cement (IRM) groups and higher rates of epithelial proliferation in the TGFβ1, basic fibroblast growth factor (bFGF), and insulin growth factor-I (IGF-I) groups compared to the MTA. S

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Romo-Arévalo, Enrique, Higinio Arzate, Gonzalo Montoya-Ayala, and Adela Rodríguez-Romero. "High-level expression and characterization of a glycosylated human cementum protein 1 with lectin activity." FEBS Letters 590, no. 1 (2016): 129–38. http://dx.doi.org/10.1002/1873-3468.12032.

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Komaki, M., M. Kang, and A. S. Narayanan. "Role of MAP Kinases p42erk-2/p44erk-1 in Cementum-derived Attachment-protein-mediated Cell Attachment." Journal of Dental Research 79, no. 10 (2000): 1789–93. http://dx.doi.org/10.1177/00220345000790101001.

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Correa, Rodrigo, Jesús Arenas, Gonzalo Montoya, et al. "Synthetic cementum protein 1–derived peptide regulates mineralization in vitro and promotes bone regeneration in vivo." FASEB Journal 33, no. 1 (2018): 1167–78. http://dx.doi.org/10.1096/fj.201800434rr.

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Garna, Devy, Manmeet Kaur, Francis J. Hughes, and Mandeep Ghuman. "Comparison of the Expression of Periodontal Markers in Dental and Bone Marrow-derived Mesenchymal Stem Cells." Open Dentistry Journal 14, no. 1 (2020): 196–202. http://dx.doi.org/10.2174/1874210602014010196.

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Background: Periodontal ligament stem cells are a source of mesenchymal stem cells, but it is unclear whether their phenotype is distinct from mesenchymal stem cells derived from different tissues, such as those derived from bone marrow. Objective: To investigate the expression of the putative PDL markers asporin, periostin, nestin and cementum protein 1, by periodontal ligament stem cells both constitutively and during osteogenic differentiation when compared to bone marrow-derived mesenchymal stem cells, and dental pulp stem cells. Methods: The primary human periodontal ligament, bone marrow

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Villegas-Mercado, C. E., L. T. Agredano-Moreno, M. Bermúdez, et al. "Cementum protein 1 transfection does not lead to ultrastructural changes in nucleolar organization of human gingival fibroblasts." Journal of Periodontal Research 53, no. 4 (2018): 636–42. http://dx.doi.org/10.1111/jre.12553.

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Dab, Sandeep, Nancy Abdelhay, Carlos Alberto Figueredo, Seema Ganatra, and Monica Prasad Gibson. "Characterization of SIBLING Proteins in the Mineralized Tissues." Dentistry Journal 10, no. 8 (2022): 144. http://dx.doi.org/10.3390/dj10080144.

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The SIBLING proteins are a family of non-collagenous proteins (NCPs) previously thought to be expressed only in dentin but have been demonstrated in other mineralized and non-mineralized tissues. They are believed to play vital roles in both osteogenesis and dentinogenesis. Since they are tightly regulated lifelong processes and involve a peak of mineralization, three different age groups were investigated. Fifteen wild-type (WT) mice were euthanized at ages 1, 3, and 6 months. Hematoxylin and eosin staining (H&E) was performed to localize various microscopic structures in the mice mandibl

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Das, Neelam. "Periodontal Ligament-associated Protein-1/Asporin in Periodontal Health: A Crucial Regulator of Oral and Systemic Function." Indian Journal of Dental Sciences 17, no. 1 (2025): 26–31. https://doi.org/10.4103/ijds.ijds_117_24.

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The periodontal ligament (PDL) is a specialized, vascularized fibrous tissue that anchors teeth to the alveolar bone, supports mechanical actions like chewing, and aids in tissue maintenance, wound repair, and regeneration. It is mainly composed of fibroblasts that form a network of key fibers linking the tooth root’s cementum to the alveolar bone. Recently, PDL-associated protein-1 (PLAP-1), also known as asporin, a member of the small leucine-rich proteoglycan family, has been identified as a crucial protein within the PDL. Asporin plays a key role in maintaining tissue balance by regulating

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Yokokoji, Takayoshi, and A. S. Narayanan. "Role of D 1 and E Cyclins in Cell Cycle Progression of Human Fibroblasts Adhering to Cementum Attachment Protein." Journal of Bone and Mineral Research 16, no. 6 (2001): 1062–67. http://dx.doi.org/10.1359/jbmr.2001.16.6.1062.

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Kato, Akihito, Hirofumi Miyaji, Ryosuke Ishizuka, et al. "Combination of Root Surface Modification with BMP-2 and Collagen Hydrogel Scaffold Implantation for Periodontal Healing in Beagle Dogs." Open Dentistry Journal 9, no. 1 (2015): 52–59. http://dx.doi.org/10.2174/1874210601509010052.

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Objective : Biomodification of the root surface plays a major role in periodontal wound healing. Root surface modification with bone morphogenetic protein (BMP) stimulates bone and cementum-like tissue formation; however, severe ankylosis is simultaneously observed. Bio-safe collagen hydrogel scaffolds may therefore be useful for supplying periodontal ligament cells and preventing ankylosis. We examined the effects of BMP modification in conjunction with collagen hydrogel scaffold implantation on periodontal wound healing in dogs. Material and Methods: The collagen hydrogel scaffold was compos

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KADOKURA, HIROSHI, TAKAHIDE YAMAZAKI, YOSHIKO MASUDA, et al. "Establishment of a Primary Culture System of Human Periodontal Ligament Cells that Differentiate into Cementum Protein 1-expressing Cementoblast-like Cells." In Vivo 33, no. 2 (2019): 349–52. http://dx.doi.org/10.21873/invivo.11480.

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Wang, J., D. Massoudi, Y. Ren, et al. "BMP1 and TLL1 Are Required for Maintaining Periodontal Homeostasis." Journal of Dental Research 96, no. 5 (2017): 578–85. http://dx.doi.org/10.1177/0022034516686558.

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Mutations in bone morphogenetic protein 1 (BMP1) in humans or deletion of BMP1 and related protease tolloid like 1 (TLL1) in mice lead to osteogenesis imperfecta (OI). Here, we show progressive periodontal defects in mice in which both BMP1 and TLL1 have been conditionally ablated, including malformed periodontal ligament (PDL) (recently shown to play key roles in normal alveolar bone formation), significant loss in alveolar bone mass ( P < 0.01), and a sharp reduction in cellular cementum. Molecular mechanism studies revealed a dramatic increase in the uncleaved precursor of type I collage

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Sanchez, Nerea, Fabio Vignoletti, Ignacio Sanz-Martin, et al. "Cell Therapy Based on Gingiva-Derived Mesenchymal Stem Cells Seeded in a Xenogeneic Collagen Matrix for Root Coverage of RT1 Gingival Lesions: An In Vivo Experimental Study." International Journal of Molecular Sciences 23, no. 6 (2022): 3248. http://dx.doi.org/10.3390/ijms23063248.

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(1) Background: To investigate the effect of a xenogeneic collagen matrix (CMX) seeded with autologous gingiva-derived mesenchymal cells (GMSCs) when combined with a coronally advanced flap (CAF) in the treatment of localized gingival recession type 1 (RT1). (2) Methods: Dehiscence-type defects were created in seven dogs. GMSCs were isolated, transfected with a vector carrying green fluorescent protein (GFP) and expanded. Once chronified, the defects were randomly treated with (1) CAF plus the combination of CMX and GFP+ GMSCs, (2) CAF plus CMX with autologous fibroblasts, (3) CAF plus CMX and

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Colorado, Catalina, Lina M. Escobar, Gloria Inés Lafaurie, Camilo Durán, and Sandra Janneth Perdomo-Lara. "Human recombinant cementum protein 1, dental pulp stem cells, and PLGA/hydroxyapatite scaffold as substitute biomaterial in critical size osseous defect repair in vivo." Archives of Oral Biology 137 (May 2022): 105392. http://dx.doi.org/10.1016/j.archoralbio.2022.105392.

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MacDougall, Mary, Aaron Unterbrink, David Carnes, Sheela Rani, Xianhong Luan, and Shuo Chen. "Utilization of M06-G3 Immortalized Odontoblast Cells in Studies Regarding Dentinogenesis." Advances in Dental Research 15, no. 1 (2001): 25–29. http://dx.doi.org/10.1177/08959374010150010601.

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Tooth formation is the result of reciprocal instructive interactions between oral epithelium and cranial neural-crest-derived ectomesenchymal tissues. These interactions lead to the cytodifferentiation of highly specialized matrix-forming cell types, the ameloblast, odontoblast, and cementoblast, that produce the mineralized tissues enamel, dentin, and cementum, respectively. Our laboratory has been developing immortalized dental cell lines representative of these various cell types to facilitate studies on gene regulation, cell differentiation, matrix formation, and mineralization. Odontoblas

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Yong, Jiawen, Sabine Gröger, Julia von Bremen, and Sabine Ruf. "Ciliary Neurotrophic Factor (CNTF) Inhibits In Vitro Cementoblast Mineralization and Induces Autophagy, in Part by STAT3/ERK Commitment." International Journal of Molecular Sciences 23, no. 16 (2022): 9311. http://dx.doi.org/10.3390/ijms23169311.

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In animal models, the administration of ciliary neurotrophic factor (CNTF) was demonstrated to reduce bone mass and to participate in bone remodeling. Cementoblasts, a cell type embedded in the cementum, are the main cells to produce and mineralize the extracellular matrix. The effect of CNTF on cementoblasts has not yet been addressed. Thus, the goal of this in vitro study was to investigate possible influences of exogenous CNTF on cementogenesis, as well as autophagy regulation and subsequent mechanisms in cementoblasts. Cementoblasts (OCCM-30) were stimulated with exogenous CNTF. Alizarin R

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Lamia, AF, A. Aminlari, T. Botero, et al. "Cellular Aging promotes CEMP1 Expression in STRO-1 positive PDL cells." July 18, 2016. https://doi.org/10.19070/2377-8075-1600057.

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We investigated the effects of cellular aging on the expression of cementum and mineralization-specific proteins in human periodontal ligament (PDL) cells, since this is not well studied. Previously, we showed that STRO-1- and cementum protein 1 (CEMP1) - positive PDL cells behave like cementoblasts, since they can be directed toward cementogenesis. However, the mineralization characteristics of these cells during aging have not been examined. Thus, we examined mineralization and expression of the mineralization-related proteins, CEMP1, collagen I (COL I) and osteopontin (OPN) in STRO-1 positi

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Romo-Arévalo, Enrique, Eduardo Villarreal-Ramírez, Juan L. Chávez-Pacheco, Cristina Piña-Barba, M. Aguilar-Franco, and Higinio Arzate. "In Vitro Effects of Cementum Protein 1 (CEMP1) on Calcium Phosphate Crystal Formation and its Role During the Mineralization Process." MRS Proceedings 1244 (2009). http://dx.doi.org/10.1557/proc-1244-5.

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ABSTRACTCementum contains specific molecules that could serve to identify, isolate and characterize the cementoblast lineage and to determine the cellular and molecular mechanisms that regulate the cementogenesis process, since it plays a key role during the periodontal regeneration process. One of these molecules is the human cementum protein 1 (CEMP1); which has a molecular weight of 25,9 kDa. In vitro experiments have shown that CEMP1 promotes cellular adhesion and differentiation. In addition, this protein has been implied in regulating the degree of deposition, composition and morphology

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Campos, Mikado Nidome, Estefanía López Giraldo, Federico del Rio Portilla, Daniel Alejandro Fernández‐Velasco, Higinio Arzate, and Enrique Romo‐Arévalo. "Solution NMR structure of cementum protein 1 derived peptide (CEMP1‐p1) and its role in the mineralization process." Journal of Peptide Science, April 13, 2023. http://dx.doi.org/10.1002/psc.3494.

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Maldonado, Silvia, Enrique Romo, Janeth Serrano, et al. "Cementum protein 1 (CEMP1) activates p38 and JNK during the mineralisation process by cementoblast-like cells in vitro." Cell Biology International Reports, December 2013, n/a. http://dx.doi.org/10.1002/cbi3.10011.

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Ebadi, Morvarid, Amirfarhang Miresmaeili, Shahrokh Shojaei, Sareh Farhadi, and Sarah Rajabi. "Isolation and characterization of apical papilla cells from root end of human third molar and their differentiation into cementoblast cells: an in vitro study." Biological Procedures Online 25, no. 1 (2023). http://dx.doi.org/10.1186/s12575-023-00190-6.

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Abstract Background Periodontal regeneration, treatment of periodontal-related diseases and improving the function of implants are global therapeutic challenges. The differentiation of human stem cells from apical papilla into cementoblasts may provide a strategy for periodontitis treatment. This study aimed to evaluate the differentiation of primary human stem cells apical papilla (hSCAPs) to cementoblast cells. Material and methods SCAPs cells were isolated from human third molar and then incubated for 21 days in a differentiation microenvironment. Alkaline phosphatase (ALP) and Alizarin red

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Montoya, Gonzalo, Rodrigo Correa, Jesús Arenas, et al. "Cementum protein 1‐derived peptide (CEMP 1‐p1) modulates hydroxyapatite crystal formation in vitro." Journal of Peptide Science 25, no. 10 (2019). http://dx.doi.org/10.1002/psc.3211.

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Hakki, Sema S., Serife Buket Bozkurt, Anton Sculean, and Darko Božić. "Hyaluronic acid enhances cell migration, viability, and mineralized tissue‐specific genes in cementoblasts." Journal of Periodontal Research, December 9, 2023. http://dx.doi.org/10.1111/jre.13201.

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AbstractBackground/ObjectivesIt has been repeatedly demonstrated that cementum formation is a crucial step in periodontal regeneration. Hyaluronic acid (HA) is an important component of the extracellular matrix which regulates cells functions and cell–cell communication. Hyaluronic acid/derivatives have been used in regenerative periodontal therapy, but the cellular effects of HA are still unknown. To investigate the effects of HA on cementoblast functions, cell viability, migration, mineralization, differentiation, and mineralized tissue‐associated genes and cementoblast‐specific markers of t

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Rodríguez, Lía Hoz, Maricela Santana Vázquez, Luis Fernando Ramírez González, et al. "Cementum attachment protein‐derived peptide induces cementum formation." FASEB BioAdvances, December 30, 2024. https://doi.org/10.1096/fba.2024-00119.

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AbstractA pentapeptide AVIFM (CAP‐p5) derived from the carboxy‐terminus end of cementum attachment protein was examined for its role on proliferation, differentiation, and mineralization of human periodontal ligament cells (HPLC), and for its potential to induce cementum deposition in vivo. CAP‐p5 capability to induce hydroxyapatite crystal formation on demineralized dentin blocks was characterized by scanning electron microscopy, μRAMAN, and high‐resolution transmission electron microscopy. The results revealed that CAP‐p5 promoted cell proliferation and cell differentiation and increases alk

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Hoz, Lía, Sonia López, Margarita Zeichner‐David, and Higinio Arzate. "Regeneration of rat periodontium by cementum protein 1‐derived peptide." Journal of Periodontal Research, September 12, 2021. http://dx.doi.org/10.1111/jre.12921.

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Nagasaki, A., K. Nagasaki, E. Y. Chu, et al. "Ablation of Pyrophosphate Regulators Promotes Periodontal Regeneration." Journal of Dental Research, December 24, 2020, 002203452098185. http://dx.doi.org/10.1177/0022034520981854.

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Biomineralization is regulated by inorganic pyrophosphate (PPi), a potent physiological inhibitor of hydroxyapatite crystal growth. Progressive ankylosis protein (ANK) and ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) act to increase local extracellular levels of PPi, inhibiting mineralization. The periodontal complex includes 2 mineralized tissues, cementum and alveolar bone (AB), both essential for tooth attachment. Previous studies demonstrated that loss of function of ANK or ENPP1 (reducing PPi) resulted in increased cementum formation, suggesting PPi metabolism may be a targe

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Huang, X., L. Ma, X. Wang, et al. "Ckip-1 Mediates P. gingivalis–Suppressed Cementoblast Mineralization." Journal of Dental Research, December 7, 2021, 002203452110547. http://dx.doi.org/10.1177/00220345211054744.

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Porphyromonas gingivalis is responsible for the destruction of cementum in patients with periodontitis and periapical periodontitis. However, research about the effects of P. gingivalis on cementoblast mineralization and the underlying mechanism is still lacking. Casein kinase 2 interacting protein 1 (Ckip-1) is a scaffold protein that interacts with various proteins and signals to regulate different cell functions, such as cell morphology, apoptosis, and differentiation. In this study, we verified the suppressive effects of P. gingivalis and lipopolysaccharide (Pg-LPS) on OCCM-30 mineralizati

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