Academic literature on the topic 'Center for Perinatal Biology'

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Journal articles on the topic "Center for Perinatal Biology"

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Vanyarkina, Anastasiya, Alla Petrova, Lyubov Rychkova, Ekaterina Moskaleva, and Evgeniya Novikova. "Socio-Demographic Factors and Epidemiological Characteristics of HIV-Positive Pregnant Women with High Risk of Vertical Transmission of the Immunodeficiency Virus." International Journal of Biomedicine 11, no. 4 (December 10, 2021): 564–69. http://dx.doi.org/10.21103/article11(4)_oa27.

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The purpose of this study was to determine the features of the course of pregnancy, delivery, and the postpartum period in HIV-positive women with a high risk of HIV vertical transmission. Methods and Results: A retrospective, longitudinal cohort study of mother-child pairs for the period from 2017 to 2019 was conducted in the Irkutsk City Perinatal Center (level III). The clinical observation group included HIV-positive women (n=213) and their newborn children with a high risk of perinatal immunodeficiency virus transmission (n=214). The findings of the conducted study demonstrated that most HIV-seropositive women with a high risk of HIV vertical transmission had an aggravated social history, a high prevalence of pelvic inflammatory diseases, and a high incidence of opportunistic and AIDS-defining conditions. Evaluation of PMTCT preventive complex showed that the target parameters in women with a high risk of HIV transmission were not reached: the first stage was performed for 49.3% of pregnant women with good ART adherence, the second stage – for 97.1% of obstetric patients, the third stage – in 100% of HIV perinatally exposed children. HIV RNA was detected in 3.7% of children, which evidences their antenatal infection. Conclusion: Development of efficient communication with HIV-positive women aimed at preservation of their health and decrease of logistic barriers to access to medical care.
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Manaenkova, T. L., T. A. Bairova, A. Yu Sambyalova, A. I. Paramonov, E. V. Belyaeva, O. V. Bugun, and L. V. Rychkova. "Comorbid disease in children and adolescents with perinatal HIV infection: A pilot study." Acta Biomedica Scientifica 7, no. 5-2 (December 10, 2022): 74–85. http://dx.doi.org/10.29413/abs.2022-7.5-2.8.

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Background. With the increased use of combination antiretroviral therapy, the mortality of people living with HIV has decreased significantly, which has led to an increase of comorbidity and secondary HIV-related pathology in both adults and also in children and adolescents living with HIV infection. The incidence of children and adolescents with HIV infection and those in the general population varies significantly.The aim. To assess the frequency and range of chronic comorbidities in children and adolescents with perinatal HIV infection Methods. We carried out an observational study. Data on the incidence of 161 children with perinatal HIV infection registered in the Irkutsk Regional AIDS Center were copied.Results. Overall incidence of tuberculosis (18633.5 per 100 000 children), diseases of the digestive system (24844.7 per 100 000 children), diseases of the eye and adnexa (28571.4 per 100 000 children), diseases of the nervous system (18012.4 per 100 000 children), mental and behavioral disorders (13,664.6 per 100 000 children) in children with perinatal HIV infection is the higher than in children of comparable age. The overall incidence values of the endocrine system diseases, eating and metabolic disorders, diseases of the ear and mastoid process, diseases of the circulatory system, diseases of the genitourinary system, as well as congenital disorders and chromosomal disorders in children and adolescents with and without perinatal HIV infection are comparable.Conclusion. The prevalence of diseases of the circulatory, respiratory and genitourinary systems in children with perinatal HIV infection is comparable to that in the corresponding population. Prevalence of tuberculosis, anemia, diseases of the gastrointestinal tract, diseases of the eye and adnexa, diseases of the nervous system, mental and behavioral disorders is higher compared to children not exposed to HIV.
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Babu, Mahesh, Bhavya H U, and Shyam Sundar S. "To evaluate the tests of antepartum fetal surveillance for predicting adverse perinatal outcome in pregnancy with IUGR." Indian Journal of Obstetrics and Gynecology Research 8, no. 2 (June 15, 2021): 235–39. http://dx.doi.org/10.18231/j.ijogr.2021.048.

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IUGR is one of the most common pregnancy complications which substantially increase risk of adverse neonatal outcome. The sequelae of IUGR include stillbirth, neuro-developmental delay in childhood and high risk of diseases like hypertension, diabetes in adulthood. Therefore, IUGR in pregnancy warrants intensive antepartum fetal surveillance to ensure optimal perinatal outcome.To evaluate the tests of antepartum fetal surveillance like AFI, BPS and Doppler ultrasound, alone and in combination for predicting adverse perinatal outcome in pregnancy with IUGR.This was a prospective observational study done on 100 pregnant IUGR women > 34weeks of gestation, at a tertiary care centre in Karnataka, from June 2017 till December 2018. They were monitored by tests of fetal surveillance like Amniotic Fluid Index (AFI), Bio Physical score (BPS) and Doppler ultrasound. Tests done within 48 hours before labour and its relation to perinatal outcome were assessed. Continuous data such as age, height, weight were described by mean and standard deviation. The sensitivity specificity, positive and negative predictive value were calculated for each test.The statistical difference between the normal and abnormal tests of antepartum fetal surveillance in relation to perinatal outcome was significant. Diagnostic accuracy of Doppler was 67%, BPS and AFI was 69%. In case of combination of findings of BPS and Doppler, the accuracy rose to 75%.Biophysical profile was most reliable diagnostic method than Doppler in predicting adverse outcome. Sensitivity increased when BPS and Doppler was combined which is beneficial in predicting perinatal outcome.
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Asare, Eugenia Vicky Naa Kwarley, Yvonne Adomakoh, Edeghonghon Olayemi, Enoch Mensah, Harriet Ghansah, Yvonnne Osei- Bonsu, Selina Crabbe, et al. "Prospective Implementation of Multi-Disciplinary Obstetric Team Decreases the Mortality Rate of Pregnant Women with Sickle Cell Disease in Ghana." Blood 128, no. 22 (December 2, 2016): 1017. http://dx.doi.org/10.1182/blood.v128.22.1017.1017.

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Abstract Introduction: Pregnant women with sickle cell disease (SCD) are at increased risk for both pregnancy and SCD related morbidity and mortality. At the Korle-Bu Teaching Hospital (KBTH), a national referral center in Accra, Ghana, the estimated maternal mortality ratio of women with and without SCD is 8,300 and 690 per 100,000 live births respectively (US, general population, maternal mortality ratio 14 per 100, 000 live births). In 2015, a multi-disciplinary obstetric SCD team was formed comprising obstetricians, hematologists, pulmonologists and nurses. In a before and after study design, we tested the hypothesis that implementing a multi-disciplinary team for care of pregnant women with SCD would significantly decrease maternal mortality. Methodology: The study received ethical approval from the Ethical and Protocol Review Committee, College of Health Sciences, University of Ghana Institutional Review Board and Vanderbilt University Medical Center (Data Coordinating Center (DCC). The pre-intervention period was from January 2014 to April 2015, and the post intervention period was May 2015 to May 2016. During the intervention period, members of the multi-disciplinary team evaluated participants at enrollment, during outpatient visits and during acute illnesses (inpatient and outpatient). Simple protocols were implemented for preventing and treating Acute Chest Syndrome (ACS). Balloons were purchased (substituted for incentive spirometry devices) and used routinely during management of acute pain episodes and after surgery. Multiple pulse oximetry machines were integrated into routine clinical practice for monitoring of oxygen desaturation. Close maternal and fetal monitoring were implemented. During the pre-intervention period, pregnant women were admitted to multiple wards throughout the hospital. Post-intervention, pregnant women were primarily admitted to two designated wards at the Obstetrics Department, for better coordinated care. All participants in the post-intervention period were followed from enrollment until six weeks postpartum. Members of the clinical research team and DCC adjudicated every vaso-occlusive pain episode, ACS episode, and acute event requiring hospitalization. Pain was defined as an acute episode, unrelated to labor and requiring hospitalization. ACS was defined based on the presence of at least 2 of the following criteria: fever, increased respiratory rate, chest pain, pulmonary auscultatory findings, increased O2 requirement or new radiodensity on chest roentgenogram. Results: A total of 154 and 91 deliveries by women with SCD were evaluated in the pre- and post-intervention period, respectively. The median age for cases in the pre-intervention period was 29 (range 18- 43) years. The median age for cases in post-intervention period was 29 (range 18-41) years and 35 participants had hemoglobin SSand 56had HbSC. Among the 91 participants, rates of pain and ACS were 194.6 (64/32.89) and 42.6 (14/32.89) events per 100 patient-years, respectively. Median gestational age at enrollment was 24 (range 7 - 40) weeks. Median gestational age at delivery was 38 (range 26 - 41) weeks. Perinatal mortality rates pre- and post-intervention were 74.3 per 1000 total births (11/ 148 X 1000) and 54.9 per 1000 total births (5/91 X 1000) respectively. Maternal mortality pre- and post-intervention were 9.7% (15 of 154) and 1.1% (1 of 91) of total deliveries respectively. The maternal mortality ratio pre- and post-intervention were 10,949 (15/137) and 1,163 (1/86) per 100,000 live births respectively. Cause of death pre-intervention period included: cardiopulmonary disease-60.0%, preeclampsia-6.67%, acute kidney injury-6.67%, severe anemia-20.0%, hypovolemic shock-6.67%. During the post-intervention period, the only death was an autopsy confirmed massive pulmonary embolism four days postpartum. Conclusion: In a low and middle income setting, a multidisciplinary team approach to care of pregnant women with SCD can dramatically decrease maternal mortality, as well as perinatal mortality. Further strategies must be employed to decrease the SCD related maternal mortality and perinatal mortality rates to levels expected in the non-SCD population and to implement multi-disciplinary SCD obstetric teams in other regions. Disclosures Asare: Vanderbilt University Medical Center Gift Funds: Research Funding; Intramural University of Ghana Research fund: Research Funding. Adomakoh:Vanderbilt University Medical Center Gift Funds: Research Funding; Intramural University of Ghana Research fund: Research Funding. Olayemi:Intramural University of Ghana Research fund: Research Funding; Vanderbilt University Medical Center Gift Funds: Research Funding. Mensah:Vanderbilt University Medical Center Gift Funds: Research Funding; Intramural University of Ghana Research fund: Research Funding. Ghansah:Vanderbilt University Medical Center Gift Funds: Research Funding; Intramural University of Ghana Research fund: Research Funding. Osei- Bonsu:Vanderbilt University Medical Center Gift Funds: Research Funding; Intramural University of Ghana Research fund: Research Funding. Crabbe:Vanderbilt University Medical Center Gift Funds: Research Funding; Intramural University of Ghana Research fund: Research Funding. Musah:Vanderbilt University Medical Center Gift Funds: Research Funding; Intramural University of Ghana Research fund: Research Funding. Hayfron- Benjamin:Vanderbilt University Medical Center Gift Funds: Research Funding; Intramural University of Ghana Research fund: Research Funding. Boafor:Vanderbilt University Medical Center Gift Funds: Research Funding; Intramural University of Ghana Research fund: Research Funding. Kassim:Vanderbilt University Medical Center Gift Funds: Research Funding; Intramural University of Ghana Research fund: Research Funding. James:Vanderbilt University Medical Center Gift Funds: Research Funding; Intramural University of Ghana Research Fund: Research Funding. Oppong:Vanderbilt University Medical Center Gift Funds: Research Funding; Intramural University of Ghana Research fund: Research Funding.
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Nouri, Kazem, Johannes Ott, Lucia Stoegbauer, Detlef Pietrowski, Sophie Frantal, and Katharina Walch. "Obstetric and perinatal outcomes in IVF versus ICSI-conceived pregnancies at a tertiary care center - a pilot study." Reproductive Biology and Endocrinology 11, no. 1 (2013): 84. http://dx.doi.org/10.1186/1477-7827-11-84.

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Mohammadi, Solmaz, Kobra Shojaei, Elham Maraghi, and Zahra Motaghi. "Quality of perinatal care for women with high-risk pregnancies during the COVID-19 pandemic in Iran." Journal of International Medical Research 50, no. 7 (July 2022): 030006052211067. http://dx.doi.org/10.1177/03000605221106723.

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Background COVID-19 has had a catastrophic effect on the healthcare system. Healthcare quality assessment measures the difference between expected and actual performances to identify gaps in the healthcare system. This study aimed to evaluate the quality of perinatal care for women with high-risk pregnancies (HPR) during the COVID-19 pandemic. Materials and Methods This cross-sectional study enrolled 450 women with HPR from health centers in Ahvaz, Iran, from December 2020 to May 2021, using a multi-stage sampling method. Quality of care was assessed using an observational checklist adapted from Ministry of Health guidelines. Data were analyzed using descriptive and statistical methods. Results The quality of the assessed aspect in comprehensive health centers and in peripartum, perinatal, and postpartum wards was moderate. The overall score for peripartum care was significantly positively correlated with the length of the retraining period, and the quality of perinatal care was significantly related to the proportion of elective cesarean sections and preterm delivery. Conclusion The development of care practices in health centers in Iran should focus on education and counseling. Practices in peripartum wards should emphasize the use of partographs, physical/mental support, and privacy for mothers, while perinatal wards should focus on timely counseling.
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Pronina, Tatiana, Ekaterina Pavlova, Liliya Dil’mukhametova, and Michael Ugrumov. "Development of the Periventricular Nucleus as a Brain Center, Containing Dopaminergic Neurons and Neurons Expressing Individual Enzymes of Dopamine Synthesis." International Journal of Molecular Sciences 23, no. 23 (November 24, 2022): 14682. http://dx.doi.org/10.3390/ijms232314682.

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We have recently shown that the periventricular nucleus (PeVN) of adult rats is a “mixed dopaminergic (DAergic) center” containing three thousand neurons: DAergic neurons and those expressing one of the dopamine (DA)-synthesizing enzymes. This study aims to evaluate the development of the PeVN as a mixed DAergic center in rats in the perinatal period, critical for brain morphogenesis. During this period, the PeVN contains DAergic neurons and monoenzymatic neurons expressing individual enzymes of DA synthesis: tyrosine hydroxylase (TH) or aromatic L-amino acid decarboxylase (AADC). In the perinatal period, the total number of such neurons triples, mainly due to monoenzymatic neurons; the content of L-DOPA, the end product of monoenzymatic TH neurons, doubles; and the content of DA, the end product of monoenzymatic AADC neurons and DAergic neurons, increases sixfold. Confocal microscopy has shown that, in the PeVN, all types of neurons and their processes are in close relationships, which suggests their mutual regulation by L-DOPA and DA. In addition, monoenzymatic and DAergic fibers are close to the third cerebral ventricle, located in the subependymal zone, between ependymal cells and in the supraependymal zone. These observations suggest that these fibers deliver L-DOPA and DA to the cerebrospinal fluid, participating in the neuroendocrine regulation of the brain.
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Beiguelman, Bernardo, and Carla Franchi-Pinto. "Perinatal mortality among twins and singletons in a city in southeastern Brazil, 1984-1996." Genetics and Molecular Biology 23, no. 1 (March 2000): 15–23. http://dx.doi.org/10.1590/s1415-47572000000100003.

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Analysis of 116,699 deliveries (1062 twin pairs and 115,637 singletons) which occurred from 1984 to 1996 at the largest obstetric center in Campinas, SP, Brazil, provided the following conclusions: 1) despite the low percentage of twin births (0.9%), 10.7% of all early neonatal deaths and 3.5% of all stillbirths were twins. Compared to singletons, the likelihood of stillbirths and early neonatal deaths among twins was 1.9 and 6.5 times greater, respectively. 2) The proportion of twins among early neonatal deaths tended to decrease, probably because of improvements in prenatal and perinatal care. 3) The critical period for early neonatal deaths in singletons and twins lasted for the three first days after birth. 4) The incidence of perinatal deaths among twins was highest among MM pairs, followed by FF pairs, and lowest among MF pairs. 5) There was a trend towards a decrease in the annual rate of early neonatal deaths among both singletons and twins, and of stillbirths among singletons, the latter being more conspicuous among females. 6) The sex ratio of singletons was practically stable among living newborns, but showed strong cyclic variation among early neonatal deaths, and a tendency to increase among stillbirths. Twins who died in the first week, as well as living twins showed a strong increase in their sex ratio from 1984 to 1996. 7) The mean gestational age of singletons was highest among living newborns followed by stillbirths, and was lowest among early neonatal deaths. The mean gestational age of living twins was higher than that of early neonatal deaths, but not different from that of stillbirths. 8) The mean birth weight of singletons and twins was highest among living newborns, followed by stillbirths, and lowest among early neonatal deaths. 9) Apgar scores > or = 7 obtained five minutes after birth are inadequate as a reliable indicator of the clinical condition of the newborn, since almost half of the early neonatal deaths had 5-min Apgar scores varying from 7 to 10.
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Hernández, F., A. Y. Lujano Negrete, C. M. Skinner Taylor, L. Pérez Barbosa, E. Barriga-Maldonado, R. A. Rodriguez Chavez, L. G. Espinosa Banuelos, R. Moyeda Martinez, G. Figueroa-Parra, and D. Á. Galarza-Delgado. "AB0843 OBSTETRIC AND PERINATAL OUTCOMES IN MEXICAN WOMEN WITH RHEUMATIC DISEASES." Annals of the Rheumatic Diseases 80, Suppl 1 (May 19, 2021): 1445–46. http://dx.doi.org/10.1136/annrheumdis-2021-eular.3718.

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Background:Rheumatic diseases (RD) are more frequent among women of childbearing age. Adverse events during pregnancy in RDs have been frequently reported, leading some women to avoid pregnancy. “CEER” is an outpatient clinic in Monterrey, Nuevo Leon, Mexico, that was created for pregnant women with RD.Objectives:The objective is to describe pregnancy outcomes in patients with RD surveilled at a rheumatology outpatient clinic.Methods:A single-center retrospective study of women with RD at CEER between 2017 and 2020 was conducted. Clinical features and maternal, fetal and neonatal outcomes were retrospectively collected. The rate of adverse perinatal outcomes (APO) was compared with the tertiary referral center´s general obstetric population (GOP). All data was retrieved from clinical files.Results:Overall, 62 pregnancies in women with RD were recorded. The median maternal age at conception was significantly higher in pregnancies with RD than GOP (29 [24-35] years old vs 23 [19-28] years old, p<0.001).The odds of preterm delivery were increased among pregnancies with RD (OR 1.85, 95% CI 1.03-3.30, p=0.038). Other APO are summarized in Table 1. Rheumatoid arthritis (RA) was the leading diagnosis followed by systemic erythematosus lupus (SLE) and antiphospholipid syndrome (APS).Cesarean sections were recorded in 41 pregnancies in RD group, more frequent than in GOP (66.1% vs 50.8%, p=0.016). Figure 1 shows the distribution of indications for cesarean sections, the two leading indications were previous cesarean section (43.9%) and Nonreassuring fetal heart rate pattern (19.5%) Pregnancies with RD appeared to have frequent, emergency cesarean sections and preterm deliveries compared with GOP (12.9% vs 15.9%, p=0.02 and 23.7% vs 12.2%, p=0.006, respectively).Conclusion:Pregnancies with RD were at increased risk for APO. Women of this population should be made aware of these risks and be closely monitored by a multidisciplinary team as a high-risk pregnancy.References:[1]Aljary H, Czuzoj-Shulman N, Spence AR, Abenhaim HA. Pregnancy outcomes in women with rheumatoid arthritis: a retrospective population-based cohort study. J Matern Fetal Neonatal Med. 2020;33(4):618-24.[2]Alvarez-Nemegyei J, Cervantes-Díaz MT, Avila-Zapata F, Marín-Ordóñez J. [Pregnancy outcomes before and after the onset of rheumatoid arthritis]. Rev Med Inst Mex Seguro Soc. 2011;49(6):599-604.[3]Davutoğlu EA, Ozel A, Yilmaz N, Madazli R. Pregnancy outcome in 162 women with rheumatic diseases: experience of a university hospital in Turkey. Arch Gynecol Obstet. 2017;296(6):1079-84.[4]Harris N, Eudy A, Clowse M. Patient-Reported Disease Activity and Adverse Pregnancy Outcomes in Systemic Lupus Erythematosus and Rheumatoid Arthritis. Arthritis Care Res (Hoboken). 2019;71(3):390-7.[5]Ideguchi H, Ohno S, Uehara T, Ishigatsubo Y. Pregnancy outcomes in Japanese patients with SLE: retrospective review of 55 pregnancies at a university hospital. Clin Rev Allergy Immunol. 2013;44(1):57-64.Table 1.Pregnant outcome, maternal, fetal and neonatal adverse eventsRD (n=62)GOP (n=31254)OR (CI 95%)pPregnancy outcomePregnancy lossa6 (9.68)1560 (4.99)1.94 (0.84-4.49)0.122Live birthsa60 (90.9)29694 (95)0.96 (0.67-1.35)0.8Gestational age,median (IQR) (weeks)b37.6 (37-39)39 (38-40.2)-<0.001Birth weight,mean (CI) (Kg)c2831.6(2677.4-2985.8)3022.2(2986.8-3057.6)-0.007Maternal adverse eventsPreterm deliveries(<37 weeks)a14 (23.7)3821 (12.2)1.85 (1.03-3.3)0.038<34 weeksa3 (5.1)1065 (3.4)1.42 (0.45-4.53)0.553Gestational diabetesa4 (6.5)1406 (4.5)1.43 (0.52-3.95)0.485Preeclampsiaa5 (8.1)2471 (7.89)1.02 (0.41-2.54)0.97Postpartum hemorrhagea0930 (2.97)0.27 (0.017-4.35)0.355Emergency cesarean sectiona8 (12.9)1844 (5.9)2.19 (1.05-4.57)0.037Fetal adverse eventsMiscarriagesa3 (4.8)663 (2.12)2.28 (0.71-7.29)0.164Stillbirthsa3 (4.8)897 (2.87)1.69 (0.53-5.38)0.377Congenital abnormalitiesa4 (6.5)1094 (3.5)1.84 (0.67-5.08)0.237an,%bIQR, interquartile range (25th–75th percentile)cCI, confidence interval (95%)Disclosure of Interests:None declared
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Trevisanuto, Daniele, Camilla Gizzi, Luigi Gagliardi, Stefano Ghirardello, Sandra Di Fabio, Artur Beke, Giuseppe Buonocore, et al. "Neonatal Resuscitation Practices in Europe: A Survey of the Union of European Neonatal and Perinatal Societies." Neonatology 119, no. 2 (2022): 184–92. http://dx.doi.org/10.1159/000520617.

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<b><i>Background:</i></b> We aimed to evaluate the policies and practices about neonatal resuscitation in a large sample of European hospitals. <b><i>Methods:</i></b> This was a cross-sectional electronic survey. A 91-item questionnaire focusing on the current delivery room practices in neonatal resuscitation domains was individually sent to the directors of 730 European neonatal facilities or (in 5 countries) made available as a Web-based link. A comparison was made between hospitals with ≤2,000 and those with &#x3e;2,000 births/year and between hospitals in 5 European areas (Eastern Europe, Italy, Mediterranean countries, Turkey, and Western Europe). <b><i>Results:</i></b> The response rate was 57% and included participants from 33 European countries. In 2018, approximately 1.27 million births occurred at the participating hospitals, with a median of 1,900 births/center (interquartile range: 1,400–3,000). Routine antenatal counseling (<i>p</i> &#x3c; 0.05), the presence of a resuscitation team at all deliveries (<i>p</i> &#x3c; 0.01), umbilical cord management (<i>p</i> &#x3c; 0.01), practices for thermal management (<i>p</i> &#x3c; 0.05), and heart rate monitoring (<i>p</i> &#x3c; 0.01) were significantly different between hospitals with ≤2,000 births/year and those with &#x3e;2,000 births/year. Ethical and educational aspects were similar between hospitals with low and high birth volumes. Significant variance in practice, ethical decision-making, and training programs were found between hospitals in 5 different European areas. <b><i>Conclusions:</i></b> Several recommendations about available equipment and clinical practices recommended by the international guidelines are already implemented by centers in Europe, but a large variance still persists. Clinicians and stakeholders should consider this information when allocating resources and planning European perinatal programs.
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Dissertations / Theses on the topic "Center for Perinatal Biology"

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Kee, Nohjin. "Receptor protein tyrosine kinases in perinatal developing rat kidney." Thesis, McGill University, 1996. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=20260.

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We have identified receptor protein tyrosine kinases (PTKs) that are expressed and/or activated during kidney development. mRNA from fetal rat kidneys in late gestation (embryonic day 21), was used to prepare cDNA template for polymerase chain reaction amplification with primers based on conserved regions of PTKs, and products were subcloned and sequenced. Among 346 clones, we identified epidermal growth factor receptor (EGFr), Tie 2, platelet derived growth factor receptor (PDGFr)-alpha, PDGFr-beta, Flk-1, Flt-4, fibroblast growth factor receptor (FGFr)-1, FGFr-3, FGFr-4, Met, and RYK//Nbtk-1. PTK expression was studied by immunoprecipitation and immunoblotting of kidney membrane proteins with specific antibodies. EGFr, PDGFr-alpha, FGFr-1, FGFr-3, Met, and in some cases Tie-2 protein expression was greater in fetal kidneys, as compared with kidneys from 12 week adult rats, (controls). Flk-1, PDGFr-beta, and FGFr-4 proteins were expressed comparably; Flt-4 was not detected. As a reflection of receptor PTK activity, we assessed endogenous tyrosine phosphorylation, and in vitro autophosphorylation. EGFr and PDGFr-alpha displayed activity in fetal, but not adult kidneys. FGFr-3 and Flk-1 were active in some fetal kidneys; the other PTKs were not active. Thus, in late gestational rat kidney, there are distinct patterns of receptor PTK expression and activity. EGFr, PDGFr-alpha, FGFr-3 and Flk-1 are among PTKs that are activated, and they may mediate perinatal development of renal epithelial, interstitial, or vascular structures.
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Labban, Margaret. "The effects of perinatal hypoxia on hippocampal neurogenesis /." Thesis, McGill University, 2006. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=101594.

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Schizophrenia (SCZ) is believed to be a neurodevelopmental disorder resulting from genetic and environmental factors. Obstetric complications, particularly fetal hypoxia, seem to be a risk factor for SCZ. The hippocampus is highly sensitive to ischemic episodes, and there is substantial evidence for hippocampal malfunction in SCZ. Thus, utilizing a rat model of global anoxia (15 min and 21 min) during Cesarean-section birth (C-section), hippocampal proliferation was examined in the dentate gyrus and CAI region at postnatal day 21 and day 60. Incorporation of 5-bromo-2-deoxyuridine (BrdU) was used as a marker of cell proliferation. Rats were sacrificed 2 hours after BrdU injection to quantify cell proliferation, or 4 weeks after BrdU injection to quantify survival of newly proliferating cells and to identify if these cells express a neuronal phenotype. Only rats that had undergone 15 minutes of hypoxia during C-section birth compared to C-sectioned controls, showed a significant increase in cell proliferation in the dentate gyrus on postnatal day 21. Thus perinatal hypoxia can have lasting effects on the hippocampus that depend on the duration of the hypoxic insult.
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Brake, Wayne Gerard. "Influence of perinatal and early postnatal insults on the adult dopamine stress response in rats." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0016/NQ55304.pdf.

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Ridruejo, Carlos Mateo. "Isla del Rey : a marine biology center." Thesis, Massachusetts Institute of Technology, 1996. http://hdl.handle.net/1721.1/69353.

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Thesis (M. Arch.)--Massachusetts Institute of Technology, Dept. of Architecture, 1996.
Includes bibliographical references (p. 78-79).
In our changing times many of our necessities have geared us to search for new spaces that can accommodate them. This thesis attempts to devise the use and expansion of a distinguished 18th Century building dominating a small island, Isla del Rey; in the deep sea port, Port de Mao, of Menorca. The task allows for the exploration of a specific type of intervention, which transforms both the isolated object of the historical building and the landscape of the site into a mutually dependent organization within the island a nd beyond. This design process considers the morphology of this extension (rather than addition) as an open system, so eloquently described in H. Wolfflin's Principle of Art History ...
Carlos Mateo Ridruejo.
M.Arch.
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Wall, Michelle. "Influence of perinatal anoxia and adolescent stress on the adult locomotor response to psychostimulants." Thesis, McGill University, 2011. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=103453.

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This project focused on the influence of perinatal anoxia and adolescent stress onthe adult locomotor response of rats to psychostimulants. Epidemiological evidencesuggests that obstetric complications can increase the risk for mental disorders includingschizophrenia and that early onset schizophrenia may be precipitated by stress duringadolescence. Taken together we hypothesized that these insults during two crucialperiods of brain maturation may manifest developmental alterations in dopamine (DA)function evident only at adulthood. Thus, I investigated the influence of perinatal anoxiaand chronic unpredictable adolescent stress (CUAS) on the adult locomotor response toamphetamine (AMPH) and cocaine (COC). In Study 1 I found that perinatal anoxia alonedid not affect the adult locomotor response to AMPH however caesarean birth aloneenhanced the adult locomotor response to both acute and repeated COC administration. In Study 2 I found that CUAS following perinatal anoxia did not affect the adultlocomotor response to AMPH but enhanced the adult locomotor response to acute COCadministration and resulted in a sensitized response to repeated COC administration notseen in animals born vaginally or by caesarean birth. These studies demonstrate thatcaesarean birth alone or with an added period of anoxia interact differently with CUASenhancing the adult locomotor response to COC but not to AMPH.
Ce projet porte sur l'influence de l'anoxie périnatale suivie par le stress enadolescence sur la réponse locomotrice de rats adultes à la suite de l'introduction depsychostimulants. Les données épidémiologiques suggèrent que les complicationsobstétricales peuvent augmenter le risque de désordres mentaux, y compris laschizophrénie, et que la schizophrénie précoce peut être déclenchée par le stress durantl'adolescence. Étant donné ces faits, nous avons pris comme hypothèse que ces atteintesau cours de deux périodes cruciales de la maturation du cerveau pourraient se manifesterdans des altérations développementales du fonctionnement de la dopamine (DA) qui neseraient évidentes qu'à l'âge adulte. Ainsi, j'ai étudié l'influence de l'anoxie périnatalesuivie par le stress chronique imprévisible en adolescence (CUAS) sur la réponselocomotrice à l'amphétamine (AMPH) et à la cocaïne (COC) à l'âge adulte. Dans lapremière étude, j'ai constaté que l'anoxie périnatale seule n'affecte pas la réponselocomotrice adulte à l'AMPH, cependant naître d'une césarienne a augmentéindépendamment la réponse locomotrice des adultes à l'administration aiguë et répétée dela COC. Dans la deuxième étude, j'ai constaté que le traitement CUAS suivant l'anoxiepérinatale n'a pas affecté la réponse locomotrice adulte à l'AMPH mais a augmenté laréponse locomotrice adulte suite à l'administration aiguë de la COC, et en plus, a abouti àune réponse sensibilisée à l'administration répétée de la COC qui n'a pas été vue chez lesanimaux nés par voie vaginale ou par césarienne. Ces études démontrent que la naissancepar césarienne seule et avec une période d'anoxie interagit différemment avec letraitement CUAS et produit une réponse locomotrice adulte augmentée à la COC, maispas à l'AMPH.
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Babintseva, A. G. "Perinatal risk factors of neonatal acute kidney injury in Ukraine: a 5-year retrospective single-center study." Thesis, БДМУ, 2020. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/17656.

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Ågren, Johan. "Water transport through perinatal skin : Barrier function and aquaporin water channels." Doctoral thesis, Uppsala University, Department of Women's and Children's Health, 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3369.

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While constituting a well functioning interface with the aqueous environment in utero, the skin offers a poor barrier after very preterm birth. As a result, transepidermal water loss (TEWL) is high, a fact which has important clinical consequences in these infants. To investigate the transport of water through perinatal skin and the potential role of aquaporin (AQP), a water channel protein, in this process, we determined TEWL in a group of extremely preterm infants, and in an experimental rat model we analyzed the expression and distribution of AQP in perinatal skin in relation to TEWL, skin surface hydration and water content. The effects of antenatal corticosteroids (ANS) and of restricted intake of fluids and nutrients on barrier characteristics of the perinatal skin and its AQP expression were also studied.

In infants born at 24 and 25 weeks of gestation TEWL was very high in the first days after birth and decreased with increasing postnatal age. At a postnatal age of 4 weeks, TEWL was still twice as high as previously reported in infants born at a gestational age of 25-27 weeks and four times higher than in infants born at term. In the rat model, immunohistochemical analysis revealed that AQP1 and AQP3 are abundantly expressed in the skin. AQP1 was expressed exclusively in dermal capillaries and AQP3 in basal layers of the epidermis. AQP1 and AQP3 mRNA as assessed by semiquantitative RT-PCR was higher in fetal than in adult skin. As in infants, TEWL and skin surface hydration were inversely related to gestational age in the rat. In preterm rat pups exposed to ANS, TEWL and skin surface hydration were lower than in unexposed controls, and AQP3 expression was selectively induced by ANS. In term newborn rat pups, restriction of fluid and nutrient intake resulted in a higher skin water content and higher TEWL early after birth, while at an age of 7 days TEWL was lower in fasting rat pups than in controls, although skin water content was still higher.

To conclude, TEWL is very high in extremely preterm infants early after birth and then decreases at a slower rate than previously reported for a group of slightly more mature infants.

This is the first time that the distribution and gene expression of AQP1 and AQP3 have been demonstrated in perinatal skin. The localization and expression of AQP in the skin might indicate that these water channels are involved in the regulation of skin hydration and transepidermal water transport in the fetus and newborn infant.

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Desai, Avanti N. "Effects of Perinatal Polychlorinated Biphenyl Mixtures on Estrogen Receptor Beta, Hippocampus, and Learning and Memory." Bowling Green State University / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1182713137.

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Allen, Christopher David Caballero. "Germinal center dark and light zone organization and cellular dynamics." Diss., Search in ProQuest Dissertations & Theses. UC Only, 2007. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3261258.

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Thesis (Ph.D.)--University of California, San Francisco, 2007.
Source: Dissertation Abstracts International, Volume: 68-04, Section: B, page: 2232. Adviser: Jason G. Cyster. Includes supplementary digital materials.
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Gemmel, Mary. "Perinatal SSRI Effects on Social Behavior and Neurolimbic Development: The Role of Maternal Stress." Ohio University / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1521192241954673.

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Books on the topic "Center for Perinatal Biology"

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Center for Developmental Biology and Perinatal Medicine (U.S.). Intellectual and Developmental Disabilities Branch. Intellectual and Developmental Disabilities (IDD) Branch, NICHD: Report to the NACHHD Council. Bethesda, Md.]: U.S. Dept. of Health and Human Services, National Institutes of Health, Eunice Kennedy Shriver National Institutes of Child Health and Human Development, 2009.

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International Symposium on Perinatal Biology (1988 Istituto superiore di sanità). International Symposium on Perinatal Biology. Roma: Istituto superiore de sanità, 1988.

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Steinkraus, Volker, Frauke Willems, and Cato Jans. Haut: Fotowettbewerb, Skin Biology Center, Hamburg 2002. Hamburg: Junius, 2002.

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United States. National Marine Fisheries Service. Alaska Fisheries Science Center. [Washington, D.C.?: National Marine Fisheries Service, 1991.

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Shortridge, Jennie. Love and biology at the center of the universe. New York: NAL Accent, 2008.

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Shortridge, Jennie. Love and Biology at the Center of the Universe. New York: Penguin Group USA, Inc., 2008.

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United States. Agricultural Research Service. Plant Molecular Biology Laboratory, Beltsville Agricultural Research Center, Beltsville, Maryland. Beltsville, Md: U.S. Dept. of Agriculture, Agricultural Research Service, 1989.

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Center for Biologics Evaluation and Research (U.S.) Division of Cytokine Biology. Annual report : Center for Biologics Evaluation and Research. Division of Cytokine Biology. [Bethesda, Md.]: The Center, 1992.

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Biology and violence: From birth to adulthood. Cambridge [England]: Cambridge University, 1990.

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Rabinow, Paul. Designing human practices: An experiment with synthetic biology. Chicago: The University of Chicago Press, 2012.

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Book chapters on the topic "Center for Perinatal Biology"

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Pearce, William J. "The Fetal Cerebral Circulation: Three Decades of Exploration by the LLU Center for Perinatal Biology." In Advances in Fetal and Neonatal Physiology, 177–91. New York, NY: Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4939-1031-1_16.

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Leonelli, Sabina. "Stock Center." In Encyclopedia of Systems Biology, 2013. New York, NY: Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4419-9863-7_1610.

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Honda, Hisao, and Tatsuzo Nagai. "Applications of the Cell Center Model." In Theoretical Biology, 19–37. Singapore: Springer Nature Singapore, 2022. http://dx.doi.org/10.1007/978-981-19-2916-8_3.

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Huang, Chuanxin. "Germinal Center Reaction." In Advances in Experimental Medicine and Biology, 47–53. Singapore: Springer Singapore, 2020. http://dx.doi.org/10.1007/978-981-15-3532-1_4.

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Musen, Mark A. "National Center for Biomedical Ontology." In Encyclopedia of Systems Biology, 1492. New York, NY: Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4419-9863-7_1515.

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Ubels, F. L., W. P. Meeuwsen, S. Wijkstra, and B. Oeseburg. "Perinatal Changes in Hemoglobin Concentration in Rats." In Advances in Experimental Medicine and Biology, 791–96. Boston, MA: Springer US, 1990. http://dx.doi.org/10.1007/978-1-4684-8181-5_90.

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Herrera, E., I. López-Soldado, M. Limones, E. Amusquivar, and M. P. Ramos. "Experimental Models for Studying Perinatal Lipid Metabolism." In Advances in Experimental Medicine and Biology, 95–108. Dordrecht: Springer Netherlands, 2005. http://dx.doi.org/10.1007/1-4020-3535-7_14.

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Robert, Philippe A., Ananya Rastogi, Sebastian C. Binder, and Michael Meyer-Hermann. "How to Simulate a Germinal Center." In Methods in Molecular Biology, 303–34. New York, NY: Springer New York, 2017. http://dx.doi.org/10.1007/978-1-4939-7095-7_22.

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Lyman, William D. "Perinatal AIDS: Drugs of Abuse and Transplacental Infection." In Advances in Experimental Medicine and Biology, 211–17. Boston, MA: Springer US, 1993. http://dx.doi.org/10.1007/978-1-4615-2980-4_29.

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Justice, Jason A., and Russell M. Sanchez. "A Rat Model of Perinatal Seizures Provoked by Global Hypoxia." In Methods in Molecular Biology, 155–59. New York, NY: Springer New York, 2018. http://dx.doi.org/10.1007/978-1-4939-7526-6_13.

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Conference papers on the topic "Center for Perinatal Biology"

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Mamedova, S. N. "Features of perinatal losses in very early preterm birth data of the Republican Perinatal Center of Baku." In Scientific achievements of the third millennium. LJournal, 2019. http://dx.doi.org/10.18411/scienceconf-09-2019-17.

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Kosian, P., TH Ayub, C. Jansen, U. Gembruch, and W. Merz. "Maternal and perinatal outcome in patients with portal hypertension: A single-center experience." In 30. Kongress der Deutschen Gesellschaft für Perinatale Medizin – „Wandel als Herausforderung“. Georg Thieme Verlag, 2021. http://dx.doi.org/10.1055/s-0041-1739851.

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Lavanga, M., G. Naulaers, S. Van Huffel, O. De Wel, A. Caicedo, M. Deviaene, J. Moeyersons, et al. "The implementation of an apnea-based perinatal stress calculator." In 2019 41st Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC). IEEE, 2019. http://dx.doi.org/10.1109/embc.2019.8856955.

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Plotnikova, E. Y., E. A. Badeeva, T. I. Murashkina, A. N. Lonteva, A. G. Fomenko, E. L. Shapovalova, E. G. Davydenko, E. S. Kochetkova, and A. V. Olenskay. "FEATURES OF BREASTFEEDING AND ARTIFICIAL FEEDING OF NEWBORNS OF THE PERINATAL PERIOD." In NOVEL TECHNOLOGIES IN MEDICINE, BIOLOGY, PHARMACOLOGY AND ECOLOGY. Institute of information technology, 2022. http://dx.doi.org/10.47501/978-5-6044060-2-1.336-341.

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The interrelation of anatomical and physiological features of the language during breastfeed-ing and artificial feeding with the strength of its pressure is considered. The introduction of fiber-optic diagnostics of the pressure force of the newborn's tongue, as it will facilitate the selection of the optimal diameter of the nipple outlet during artificial feeding of the child with an untenable sucking reflex.
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Toga, A. W. "The Center for Computational Biology." In 2005 IEEE Computational Systems Bioinformatics Conference (CSB'05). IEEE, 2005. http://dx.doi.org/10.1109/csb.2005.50.

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Aeyels, Bruno, Georges van der Perre, Laura Pello, Andre van Assche, and Bernard Spitz. "On-line processing of perinatal fetal heart rate and intra-uterine pressure." In 1992 14th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE, 1992. http://dx.doi.org/10.1109/iembs.1992.5761651.

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Aeyels, Van Der Perre, Pello, van Assche, and Spitz. "On-line Processing Of Perinatal Fetal Heart Rate And Intra-uterine Pressure." In Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE, 1992. http://dx.doi.org/10.1109/iembs.1992.592973.

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Сандуляк, Т. В. "ПОПЕРЕДЖУВАНІСТЬ ЗАХВОРЮВАНЬ І ВІДВОРОТНІСТЬ ПРИЧИН СМЕРТІ ПЕРЕДЧАСНО НАРОДЖЕНИХ ДІТЕЙ З ВНУТРІШНЬОУТРОБНОЮ ІНФЕКЦІЄЮ." In International Trends in Science and Technology. RS Global Sp. z O.O., 2020. http://dx.doi.org/10.31435/rsglobal_conf/30122020/7349.

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We carried out research about disease prevention and avoiding of death causes in premature babies with different body masses and intrauterine infections at the modern perinatal center. Under conditions of help localization to pregnant women and newborns and implementation of acknowledged standards of the evidence-based medicine and perinatal strategies of health care to mother and child, we found out some demographic changes in the structure of birth giving, diseases and death of premature babies. Although there is a significant improvement of medical care quality to pregnant women and newborns, as well as an increase in the survival rate among premature newborns with very little and extremely little body masses, a number of newborns has grown who suffered from long-lasting infections and hypoxi before birth, which caused negative disease side-effects
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Yunfeng Liu, Congle Zhou, Hongmei Wang, Zezhong Tang, and Haiyan Ding. "3D ultrasound in assessment of growth and development of frontal lobes in children with perinatal brain injury." In 2009 Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE, 2009. http://dx.doi.org/10.1109/iembs.2009.5332549.

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"CANNABIS USE AND ANXIETY DISORDERS DURING PREGNANCY - DUAL DISORDER TO DUAL PATIENTS." In 23° Congreso de la Sociedad Española de Patología Dual (SEPD) 2021. SEPD, 2021. http://dx.doi.org/10.17579/sepd2021p144s.

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Objectives From clinical cases of patients observed in Perinatal Psychiatry - Setúbal Hospital Center (Portugal), we conducted a review of the impact of both cannabis use and anxiety disorders during pregnancy. Methods and material Case reports and literature review of PubMed for cannabis use, anxiety disorders and pregnancy. Results and conclusions In Outpatient Perinatal Psychiatry we observed women with anxiety disorders who reported using cannabis during pregnancy. Indeed, pregnancy is a highly vulnerable period to the onset or worsening of previous anxiety symptoms. Anxiety disorders may adversely impact not only the mother, but also fetal maturation and child development. In fact, preterm labor and low birth weight are consistently linked with anxiety during pregnancy. Recent studies reveal a general increase in the use of cannabis during pregnancy, representing the most commonly used illicit drug during the perinatal period. The endocannabinoid system appears to be involved in the regulation of human fertility and pregnancy. Although still conflicting, there is data demonstrating that cannabis use during pregnancy is associated with stillbirth, preterm birth, small for gestational age, low birth weight, smaller head circumferences and increased admission to neonatal intensive care units. The use of cannabis during pregnancy is frequently a way to improve symptoms of anxiety disorders. All patients should be screened to substance use comorbid to other frequent psychiatric disorders during pregnancy, such as anxiety disorders, in order to improve the health and well-being not only of the mother, but also of the developing baby, as a dual disorder has a negative effect in both individuals.
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Reports on the topic "Center for Perinatal Biology"

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Colvin, Michael, and Masakatsu Watanabe. UC Merced Center for Computational Biology Final Report. Office of Scientific and Technical Information (OSTI), November 2010. http://dx.doi.org/10.2172/993507.

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Strange, Kevin, and Viravuth Yin. Center for Regenerative Biology and Medicine at Mount Desert Island Biological Lab. Fort Belvoir, VA: Defense Technical Information Center, June 2012. http://dx.doi.org/10.21236/ada612702.

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Yin, Viravuth, and Kevin Strange. The Center for Regenerative Biology and Medicine at Mount Desert Island Biological Lab. Fort Belvoir, VA: Defense Technical Information Center, June 2014. http://dx.doi.org/10.21236/ada612697.

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Strange, Kevin, and Viravuth Yin. The Center for Regenerative Biology and Medicine at Mount Desert Island Biological Lab. Fort Belvoir, VA: Defense Technical Information Center, June 2013. http://dx.doi.org/10.21236/ada612701.

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Strange, Kevin, and Viravuth Yin. The Center for Regenerative Biology and Medicine at Mount Desert Island Biological Lab. Fort Belvoir, VA: Defense Technical Information Center, August 2015. http://dx.doi.org/10.21236/ada621326.

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Brau, Charles A. Development of a Free-Electron Laser Center and Research in Medicine, Biology and Materials Science,. Fort Belvoir, VA: Defense Technical Information Center, May 1992. http://dx.doi.org/10.21236/ada251611.

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Trewhella, Jill. FINAL REPORT: DOE CONTRACT NUMBER FG0205ER64026 Biological Neutron Scattering: A Collaboration with the Oak Ridge Center for Structural Molecular Biology. Office of Scientific and Technical Information (OSTI), January 2011. http://dx.doi.org/10.2172/1001398.

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McDonagh, Marian, Andrea C. Skelly, Amy Hermesch, Ellen Tilden, Erika D. Brodt, Tracy Dana, Shaun Ramirez, et al. Cervical Ripening in the Outpatient Setting. Agency for Healthcare Research and Quality (AHRQ), March 2021. http://dx.doi.org/10.23970/ahrqepccer238.

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Objectives. To assess the comparative effectiveness and potential harms of cervical ripening in the outpatient setting (vs. inpatient, vs. other outpatient intervention) and of fetal surveillance when a prostaglandin is used for cervical ripening. Data sources. Electronic databases (Ovid® MEDLINE®, Embase®, CINAHL®, Cochrane Central Register of Controlled Trials, and Cochrane Database of Systematic Reviews) to July 2020; reference lists; and a Federal Register notice. Review methods. Using predefined criteria and dual review, we selected randomized controlled trials (RCTs) and cohort studies of cervical ripening comparing prostaglandins and mechanical methods in outpatient versus inpatient settings; one outpatient method versus another (including placebo or expectant management); and different methods/protocols for fetal surveillance in cervical ripening using prostaglandins. When data from similar study designs, populations, and outcomes were available, random effects using profile likelihood meta-analyses were conducted. Inconsistency (using I2) and small sample size bias (publication bias, if ≥10 studies) were assessed. Strength of evidence (SOE) was assessed. All review methods followed Agency for Healthcare Research and Quality Evidence-based Practice Center methods guidance. Results. We included 30 RCTs and 10 cohort studies (73% fair quality) involving 9,618 women. The evidence is most applicable to women aged 25 to 30 years with singleton, vertex presentation and low-risk pregnancies. No studies on fetal surveillance were found. The frequency of cesarean delivery (2 RCTs, 4 cohort studies) or suspected neonatal sepsis (2 RCTs) was not significantly different using outpatient versus inpatient dinoprostone for cervical ripening (SOE: low). In comparisons of outpatient versus inpatient single-balloon catheters (3 RCTs, 2 cohort studies), differences between groups on cesarean delivery, birth trauma (e.g., cephalohematoma), and uterine infection were small and not statistically significant (SOE: low), and while shoulder dystocia occurred less frequently in the outpatient group (1 RCT; 3% vs. 11%), the difference was not statistically significant (SOE: low). In comparing outpatient catheters and inpatient dinoprostone (1 double-balloon and 1 single-balloon RCT), the difference between groups for both cesarean delivery and postpartum hemorrhage was small and not statistically significant (SOE: low). Evidence on other outcomes in these comparisons and for misoprostol, double-balloon catheters, and hygroscopic dilators was insufficient to draw conclusions. In head to head comparisons in the outpatient setting, the frequency of cesarean delivery was not significantly different between 2.5 mg and 5 mg dinoprostone gel, or latex and silicone single-balloon catheters (1 RCT each, SOE: low). Differences between prostaglandins and placebo for cervical ripening were small and not significantly different for cesarean delivery (12 RCTs), shoulder dystocia (3 RCTs), or uterine infection (7 RCTs) (SOE: low). These findings did not change according to the specific prostaglandin, route of administration, study quality, or gestational age. Small, nonsignificant differences in the frequency of cesarean delivery (6 RCTs) and uterine infection (3 RCTs) were also found between dinoprostone and either membrane sweeping or expectant management (SOE: low). These findings did not change according to the specific prostaglandin or study quality. Evidence on other comparisons (e.g., single-balloon catheter vs. dinoprostone) or other outcomes was insufficient. For all comparisons, there was insufficient evidence on other important outcomes such as perinatal mortality and time from admission to vaginal birth. Limitations of the evidence include the quantity, quality, and sample sizes of trials for specific interventions, particularly rare harm outcomes. Conclusions. In women with low-risk pregnancies, the risk of cesarean delivery and fetal, neonatal, or maternal harms using either dinoprostone or single-balloon catheters was not significantly different for cervical ripening in the outpatient versus inpatient setting, and similar when compared with placebo, expectant management, or membrane sweeping in the outpatient setting. This evidence is low strength, and future studies are needed to confirm these findings.
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Shani, Uri, Lynn Dudley, Alon Ben-Gal, Menachem Moshelion, and Yajun Wu. Root Conductance, Root-soil Interface Water Potential, Water and Ion Channel Function, and Tissue Expression Profile as Affected by Environmental Conditions. United States Department of Agriculture, October 2007. http://dx.doi.org/10.32747/2007.7592119.bard.

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Constraints on water resources and the environment necessitate more efficient use of water. The key to efficient management is an understanding of the physical and physiological processes occurring in the soil-root hydraulic continuum.While both soil and plant leaf water potentials are well understood, modeled and measured, the root-soil interface where actual uptake processes occur has not been sufficiently studied. The water potential at the root-soil interface (yᵣₒₒₜ), determined by environmental conditions and by soil and plant hydraulic properties, serves as a boundary value in soil and plant uptake equations. In this work, we propose to 1) refine and implement a method for measuring yᵣₒₒₜ; 2) measure yᵣₒₒₜ, water uptake and root hydraulic conductivity for wild type tomato and Arabidopsis under varied q, K⁺, Na⁺ and Cl⁻ levels in the root zone; 3) verify the role of MIPs and ion channels response to q, K⁺ and Na⁺ levels in Arabidopsis and tomato; 4) study the relationships between yᵣₒₒₜ and root hydraulic conductivity for various crops representing important botanical and agricultural species, under conditions of varying soil types, water contents and salinity; and 5) integrate the above to water uptake term(s) to be implemented in models. We have made significant progress toward establishing the efficacy of the emittensiometer and on the molecular biology studies. We have added an additional method for measuring ψᵣₒₒₜ. High-frequency water application through the water source while the plant emerges and becomes established encourages roots to develop towards and into the water source itself. The yᵣₒₒₜ and yₛₒᵢₗ values reflected wetting and drying processes in the rhizosphere and in the bulk soil. Thus, yᵣₒₒₜ can be manipulated by changing irrigation level and frequency. An important and surprising finding resulting from the current research is the obtained yᵣₒₒₜ value. The yᵣₒₒₜ measured using the three different methods: emittensiometer, micro-tensiometer and MRI imaging in both sunflower, tomato and corn plants fell in the same range and were higher by one to three orders of magnitude from the values of -600 to -15,000 cm suggested in the literature. We have added additional information on the regulation of aquaporins and transporters at the transcript and protein levels, particularly under stress. Our preliminary results show that overexpression of one aquaporin gene in tomato dramatically increases its transpiration level (unpublished results). Based on this information, we started screening mutants for other aquaporin genes. During the feasibility testing year, we identified homozygous mutants for eight aquaporin genes, including six mutants for five of the PIP2 genes. Including the homozygous mutants directly available at the ABRC seed stock center, we now have mutants for 11 of the 19 aquaporin genes of interest. Currently, we are screening mutants for other aquaporin genes and ion transporter genes. Understanding plant water uptake under stress is essential for the further advancement of molecular plant stress tolerance work as well as for efficient use of water in agriculture. Virtually all of Israel’s agriculture and about 40% of US agriculture is made possible by irrigation. Both countries face increasing risk of water shortages as urban requirements grow. Both countries will have to find methods of protecting the soil resource while conserving water resources—goals that appear to be in direct conflict. The climate-plant-soil-water system is nonlinear with many feedback mechanisms. Conceptual plant uptake and growth models and mechanism-based computer-simulation models will be valuable tools in developing irrigation regimes and methods that maximize the efficiency of agricultural water. This proposal will contribute to the development of these models by providing critical information on water extraction by the plant that will result in improved predictions of both water requirements and crop yields. Plant water use and plant response to environmental conditions cannot possibly be understood by using the tools and language of a single scientific discipline. This proposal links the disciplines of soil physics and soil physical chemistry with plant physiology and molecular biology in order to correctly treat and understand the soil-plant interface in terms of integrated comprehension. Results from the project will contribute to a mechanistic understanding of the SPAC and will inspire continued multidisciplinary research.
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Koven, William, Gordon Grau, Benny Ron, and Tetsuya Hirano. Improving fry quality, survival and growth in commercially farmed fish by dietary stimulation of thyroid hormone production in premetamorphosing larvae. United States Department of Agriculture, 2004. http://dx.doi.org/10.32747/2004.7695856.bard.

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Abstract:
There is a direct correlation between successful metamorphosis from larvae to post-larvae and the quality of the resultant juveniles or fry. Juvenile quality, in turn, is a major factor influencing fish production level and market price. However, following the profound morphological and physiological changes occurring during metamorphosis, the emerging juveniles in some species characteristically demonstrate heterotrophic growth, poor pigmentation, cannibalism and generally poor survival. The white grouper (Epinephelus aeneus) in Israel and the Pacific threadfin (Polydactylussexfilis) in Hawaii are two promising candidates for mariculture that have high market value but a natural fishery that has sharply declined in recent years. Unfortunately, their potential for culture is severely hampered by variable metamorphic success limiting their production. The main objective was to compare the efficacy and economic viability of dietary or environmental iodine on metamorphic success and juvenile quality in the white grouper and the pink snapper which would lead to improved commercial rearing protocols and increased production of these species both in Israel and the US. The Hawaii Institute of Marine Biology encountered problems with the availability of pink snapper brood stock and larvae and changed to Pacific threadfin or moi which is rapidly becoming a premier aquaculture species in Hawaii and throughout the Indo-Pacific. The white grouper brood stock at the National Center for Mariculture was lost as a result of a viral outbreak following the sudden breakdown of the ozone purification system. In addition, the NCM suffered a devastating fire in the fall of 2007 that completely destroyed the hatchery and laboratory facilities although the BARD project samples were saved. Nevertheless, by studying alternate species a number of valuable findings and conclusions that can contribute to improved metamorphosis in commercially valuable marine species resulted from this collaborative effort. The Israeli group found that exposing white grouper larvae to external TH levels synchronized and increased the rate of metamorphosis. This suggested that sub-optimal synthesis of TH may be a major factor causing size heterogeneity in the larval population and high mortality through cannibalism by their larger more metamorphosed cohorts. Two protocols were developed to enrich the larvae with higher levels of the TH precursor, iodine; feeding iodine enriched Artemia or increasing the level of seawater iodine the larvae are exposed to. Results of accumulated iodine in gilthead seabream larvae indicated that the absorption of iodine from the water is markedly more efficient than feeding iodine enriched Artemia nauplii. Samples for TH, which will be analyzed shortly, will be able to determine if another dietary factor is lacking to effectively utilize surplus tissue iodine for TH synthesis. Moreover, these samples will also clarify which approach to enriching larvae with iodine, through the live food or exposure to iodine enriched seawater is the most efficient and cost effective. The American group found that moi larvae reared in ocean water, which possessed substantially higher iodine levels than those found in seawater well water, grew significantly larger, and showed increased survival compared with well water reared larvae. Larvae reared in ocean water also progressed more rapidly through developmental stages than those in low-iodine well seawater. In collaboration with Israeli counterparts, a highly specific and precise radioimmunoassay procedure for thyroid hormones and cortisol was developed. Taken altogether, the combined Hawaiian and Israeli collaborative research suggests that for teleost species of commercial value, adequate levels of environmental iodine are more determinate in metamorphosis than iodine levels in the live zooplankton food provided to the larvae. Insuring sufficiently high enough iodine in the ambient seawater offers a much more economical solution to improved metamorphosis than enriching the live food with costly liposomes incorporating iodine rich oils.
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