To see the other types of publications on this topic, follow the link: Center for Perinatal Biology.
Journal articles on the topic 'Center for Perinatal Biology'
Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles
Consult the top 50 journal articles for your research on the topic 'Center for Perinatal Biology.'
Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.
You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.
Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.
1
Vanyarkina, Anastasiya, Alla Petrova, Lyubov Rychkova, Ekaterina Moskaleva, and Evgeniya Novikova. "Socio-Demographic Factors and Epidemiological Characteristics of HIV-Positive Pregnant Women with High Risk of Vertical Transmission of the Immunodeficiency Virus." International Journal of Biomedicine 11, no. 4 (December 10, 2021): 564–69. http://dx.doi.org/10.21103/article11(4)_oa27.
Full textAbstract:
The purpose of this study was to determine the features of the course of pregnancy, delivery, and the postpartum period in HIV-positive women with a high risk of HIV vertical transmission. Methods and Results: A retrospective, longitudinal cohort study of mother-child pairs for the period from 2017 to 2019 was conducted in the Irkutsk City Perinatal Center (level III). The clinical observation group included HIV-positive women (n=213) and their newborn children with a high risk of perinatal immunodeficiency virus transmission (n=214). The findings of the conducted study demonstrated that most HIV-seropositive women with a high risk of HIV vertical transmission had an aggravated social history, a high prevalence of pelvic inflammatory diseases, and a high incidence of opportunistic and AIDS-defining conditions. Evaluation of PMTCT preventive complex showed that the target parameters in women with a high risk of HIV transmission were not reached: the first stage was performed for 49.3% of pregnant women with good ART adherence, the second stage – for 97.1% of obstetric patients, the third stage – in 100% of HIV perinatally exposed children. HIV RNA was detected in 3.7% of children, which evidences their antenatal infection. Conclusion: Development of efficient communication with HIV-positive women aimed at preservation of their health and decrease of logistic barriers to access to medical care.
2
Manaenkova, T. L., T. A. Bairova, A. Yu Sambyalova, A. I. Paramonov, E. V. Belyaeva, O. V. Bugun, and L. V. Rychkova. "Comorbid disease in children and adolescents with perinatal HIV infection: A pilot study." Acta Biomedica Scientifica 7, no. 5-2 (December 10, 2022): 74–85. http://dx.doi.org/10.29413/abs.2022-7.5-2.8.
Full textAbstract:
Background. With the increased use of combination antiretroviral therapy, the mortality of people living with HIV has decreased significantly, which has led to an increase of comorbidity and secondary HIV-related pathology in both adults and also in children and adolescents living with HIV infection. The incidence of children and adolescents with HIV infection and those in the general population varies significantly.The aim. To assess the frequency and range of chronic comorbidities in children and adolescents with perinatal HIV infection Methods. We carried out an observational study. Data on the incidence of 161 children with perinatal HIV infection registered in the Irkutsk Regional AIDS Center were copied.Results. Overall incidence of tuberculosis (18633.5 per 100 000 children), diseases of the digestive system (24844.7 per 100 000 children), diseases of the eye and adnexa (28571.4 per 100 000 children), diseases of the nervous system (18012.4 per 100 000 children), mental and behavioral disorders (13,664.6 per 100 000 children) in children with perinatal HIV infection is the higher than in children of comparable age. The overall incidence values of the endocrine system diseases, eating and metabolic disorders, diseases of the ear and mastoid process, diseases of the circulatory system, diseases of the genitourinary system, as well as congenital disorders and chromosomal disorders in children and adolescents with and without perinatal HIV infection are comparable.Conclusion. The prevalence of diseases of the circulatory, respiratory and genitourinary systems in children with perinatal HIV infection is comparable to that in the corresponding population. Prevalence of tuberculosis, anemia, diseases of the gastrointestinal tract, diseases of the eye and adnexa, diseases of the nervous system, mental and behavioral disorders is higher compared to children not exposed to HIV.
3
Babu, Mahesh, Bhavya H U, and Shyam Sundar S. "To evaluate the tests of antepartum fetal surveillance for predicting adverse perinatal outcome in pregnancy with IUGR." Indian Journal of Obstetrics and Gynecology Research 8, no. 2 (June 15, 2021): 235–39. http://dx.doi.org/10.18231/j.ijogr.2021.048.
Full textAbstract:
IUGR is one of the most common pregnancy complications which substantially increase risk of adverse neonatal outcome. The sequelae of IUGR include stillbirth, neuro-developmental delay in childhood and high risk of diseases like hypertension, diabetes in adulthood. Therefore, IUGR in pregnancy warrants intensive antepartum fetal surveillance to ensure optimal perinatal outcome.To evaluate the tests of antepartum fetal surveillance like AFI, BPS and Doppler ultrasound, alone and in combination for predicting adverse perinatal outcome in pregnancy with IUGR.This was a prospective observational study done on 100 pregnant IUGR women > 34weeks of gestation, at a tertiary care centre in Karnataka, from June 2017 till December 2018. They were monitored by tests of fetal surveillance like Amniotic Fluid Index (AFI), Bio Physical score (BPS) and Doppler ultrasound. Tests done within 48 hours before labour and its relation to perinatal outcome were assessed. Continuous data such as age, height, weight were described by mean and standard deviation. The sensitivity specificity, positive and negative predictive value were calculated for each test.The statistical difference between the normal and abnormal tests of antepartum fetal surveillance in relation to perinatal outcome was significant. Diagnostic accuracy of Doppler was 67%, BPS and AFI was 69%. In case of combination of findings of BPS and Doppler, the accuracy rose to 75%.Biophysical profile was most reliable diagnostic method than Doppler in predicting adverse outcome. Sensitivity increased when BPS and Doppler was combined which is beneficial in predicting perinatal outcome.
4
Asare, Eugenia Vicky Naa Kwarley, Yvonne Adomakoh, Edeghonghon Olayemi, Enoch Mensah, Harriet Ghansah, Yvonnne Osei- Bonsu, Selina Crabbe, et al. "Prospective Implementation of Multi-Disciplinary Obstetric Team Decreases the Mortality Rate of Pregnant Women with Sickle Cell Disease in Ghana." Blood 128, no. 22 (December 2, 2016): 1017. http://dx.doi.org/10.1182/blood.v128.22.1017.1017.
Full textAbstract:
Abstract Introduction: Pregnant women with sickle cell disease (SCD) are at increased risk for both pregnancy and SCD related morbidity and mortality. At the Korle-Bu Teaching Hospital (KBTH), a national referral center in Accra, Ghana, the estimated maternal mortality ratio of women with and without SCD is 8,300 and 690 per 100,000 live births respectively (US, general population, maternal mortality ratio 14 per 100, 000 live births). In 2015, a multi-disciplinary obstetric SCD team was formed comprising obstetricians, hematologists, pulmonologists and nurses. In a before and after study design, we tested the hypothesis that implementing a multi-disciplinary team for care of pregnant women with SCD would significantly decrease maternal mortality. Methodology: The study received ethical approval from the Ethical and Protocol Review Committee, College of Health Sciences, University of Ghana Institutional Review Board and Vanderbilt University Medical Center (Data Coordinating Center (DCC). The pre-intervention period was from January 2014 to April 2015, and the post intervention period was May 2015 to May 2016. During the intervention period, members of the multi-disciplinary team evaluated participants at enrollment, during outpatient visits and during acute illnesses (inpatient and outpatient). Simple protocols were implemented for preventing and treating Acute Chest Syndrome (ACS). Balloons were purchased (substituted for incentive spirometry devices) and used routinely during management of acute pain episodes and after surgery. Multiple pulse oximetry machines were integrated into routine clinical practice for monitoring of oxygen desaturation. Close maternal and fetal monitoring were implemented. During the pre-intervention period, pregnant women were admitted to multiple wards throughout the hospital. Post-intervention, pregnant women were primarily admitted to two designated wards at the Obstetrics Department, for better coordinated care. All participants in the post-intervention period were followed from enrollment until six weeks postpartum. Members of the clinical research team and DCC adjudicated every vaso-occlusive pain episode, ACS episode, and acute event requiring hospitalization. Pain was defined as an acute episode, unrelated to labor and requiring hospitalization. ACS was defined based on the presence of at least 2 of the following criteria: fever, increased respiratory rate, chest pain, pulmonary auscultatory findings, increased O2 requirement or new radiodensity on chest roentgenogram. Results: A total of 154 and 91 deliveries by women with SCD were evaluated in the pre- and post-intervention period, respectively. The median age for cases in the pre-intervention period was 29 (range 18- 43) years. The median age for cases in post-intervention period was 29 (range 18-41) years and 35 participants had hemoglobin SSand 56had HbSC. Among the 91 participants, rates of pain and ACS were 194.6 (64/32.89) and 42.6 (14/32.89) events per 100 patient-years, respectively. Median gestational age at enrollment was 24 (range 7 - 40) weeks. Median gestational age at delivery was 38 (range 26 - 41) weeks. Perinatal mortality rates pre- and post-intervention were 74.3 per 1000 total births (11/ 148 X 1000) and 54.9 per 1000 total births (5/91 X 1000) respectively. Maternal mortality pre- and post-intervention were 9.7% (15 of 154) and 1.1% (1 of 91) of total deliveries respectively. The maternal mortality ratio pre- and post-intervention were 10,949 (15/137) and 1,163 (1/86) per 100,000 live births respectively. Cause of death pre-intervention period included: cardiopulmonary disease-60.0%, preeclampsia-6.67%, acute kidney injury-6.67%, severe anemia-20.0%, hypovolemic shock-6.67%. During the post-intervention period, the only death was an autopsy confirmed massive pulmonary embolism four days postpartum. Conclusion: In a low and middle income setting, a multidisciplinary team approach to care of pregnant women with SCD can dramatically decrease maternal mortality, as well as perinatal mortality. Further strategies must be employed to decrease the SCD related maternal mortality and perinatal mortality rates to levels expected in the non-SCD population and to implement multi-disciplinary SCD obstetric teams in other regions. Disclosures Asare: Vanderbilt University Medical Center Gift Funds: Research Funding; Intramural University of Ghana Research fund: Research Funding. Adomakoh:Vanderbilt University Medical Center Gift Funds: Research Funding; Intramural University of Ghana Research fund: Research Funding. Olayemi:Intramural University of Ghana Research fund: Research Funding; Vanderbilt University Medical Center Gift Funds: Research Funding. Mensah:Vanderbilt University Medical Center Gift Funds: Research Funding; Intramural University of Ghana Research fund: Research Funding. Ghansah:Vanderbilt University Medical Center Gift Funds: Research Funding; Intramural University of Ghana Research fund: Research Funding. Osei- Bonsu:Vanderbilt University Medical Center Gift Funds: Research Funding; Intramural University of Ghana Research fund: Research Funding. Crabbe:Vanderbilt University Medical Center Gift Funds: Research Funding; Intramural University of Ghana Research fund: Research Funding. Musah:Vanderbilt University Medical Center Gift Funds: Research Funding; Intramural University of Ghana Research fund: Research Funding. Hayfron- Benjamin:Vanderbilt University Medical Center Gift Funds: Research Funding; Intramural University of Ghana Research fund: Research Funding. Boafor:Vanderbilt University Medical Center Gift Funds: Research Funding; Intramural University of Ghana Research fund: Research Funding. Kassim:Vanderbilt University Medical Center Gift Funds: Research Funding; Intramural University of Ghana Research fund: Research Funding. James:Vanderbilt University Medical Center Gift Funds: Research Funding; Intramural University of Ghana Research Fund: Research Funding. Oppong:Vanderbilt University Medical Center Gift Funds: Research Funding; Intramural University of Ghana Research fund: Research Funding.
5
Nouri, Kazem, Johannes Ott, Lucia Stoegbauer, Detlef Pietrowski, Sophie Frantal, and Katharina Walch. "Obstetric and perinatal outcomes in IVF versus ICSI-conceived pregnancies at a tertiary care center - a pilot study." Reproductive Biology and Endocrinology 11, no. 1 (2013): 84. http://dx.doi.org/10.1186/1477-7827-11-84.
Full text
6
Mohammadi, Solmaz, Kobra Shojaei, Elham Maraghi, and Zahra Motaghi. "Quality of perinatal care for women with high-risk pregnancies during the COVID-19 pandemic in Iran." Journal of International Medical Research 50, no. 7 (July 2022): 030006052211067. http://dx.doi.org/10.1177/03000605221106723.
Full textAbstract:
Background COVID-19 has had a catastrophic effect on the healthcare system. Healthcare quality assessment measures the difference between expected and actual performances to identify gaps in the healthcare system. This study aimed to evaluate the quality of perinatal care for women with high-risk pregnancies (HPR) during the COVID-19 pandemic. Materials and Methods This cross-sectional study enrolled 450 women with HPR from health centers in Ahvaz, Iran, from December 2020 to May 2021, using a multi-stage sampling method. Quality of care was assessed using an observational checklist adapted from Ministry of Health guidelines. Data were analyzed using descriptive and statistical methods. Results The quality of the assessed aspect in comprehensive health centers and in peripartum, perinatal, and postpartum wards was moderate. The overall score for peripartum care was significantly positively correlated with the length of the retraining period, and the quality of perinatal care was significantly related to the proportion of elective cesarean sections and preterm delivery. Conclusion The development of care practices in health centers in Iran should focus on education and counseling. Practices in peripartum wards should emphasize the use of partographs, physical/mental support, and privacy for mothers, while perinatal wards should focus on timely counseling.
7
Pronina, Tatiana, Ekaterina Pavlova, Liliya Dil’mukhametova, and Michael Ugrumov. "Development of the Periventricular Nucleus as a Brain Center, Containing Dopaminergic Neurons and Neurons Expressing Individual Enzymes of Dopamine Synthesis." International Journal of Molecular Sciences 23, no. 23 (November 24, 2022): 14682. http://dx.doi.org/10.3390/ijms232314682.
Full textAbstract:
We have recently shown that the periventricular nucleus (PeVN) of adult rats is a “mixed dopaminergic (DAergic) center” containing three thousand neurons: DAergic neurons and those expressing one of the dopamine (DA)-synthesizing enzymes. This study aims to evaluate the development of the PeVN as a mixed DAergic center in rats in the perinatal period, critical for brain morphogenesis. During this period, the PeVN contains DAergic neurons and monoenzymatic neurons expressing individual enzymes of DA synthesis: tyrosine hydroxylase (TH) or aromatic L-amino acid decarboxylase (AADC). In the perinatal period, the total number of such neurons triples, mainly due to monoenzymatic neurons; the content of L-DOPA, the end product of monoenzymatic TH neurons, doubles; and the content of DA, the end product of monoenzymatic AADC neurons and DAergic neurons, increases sixfold. Confocal microscopy has shown that, in the PeVN, all types of neurons and their processes are in close relationships, which suggests their mutual regulation by L-DOPA and DA. In addition, monoenzymatic and DAergic fibers are close to the third cerebral ventricle, located in the subependymal zone, between ependymal cells and in the supraependymal zone. These observations suggest that these fibers deliver L-DOPA and DA to the cerebrospinal fluid, participating in the neuroendocrine regulation of the brain.
8
Beiguelman, Bernardo, and Carla Franchi-Pinto. "Perinatal mortality among twins and singletons in a city in southeastern Brazil, 1984-1996." Genetics and Molecular Biology 23, no. 1 (March 2000): 15–23. http://dx.doi.org/10.1590/s1415-47572000000100003.
Full textAbstract:
Analysis of 116,699 deliveries (1062 twin pairs and 115,637 singletons) which occurred from 1984 to 1996 at the largest obstetric center in Campinas, SP, Brazil, provided the following conclusions: 1) despite the low percentage of twin births (0.9%), 10.7% of all early neonatal deaths and 3.5% of all stillbirths were twins. Compared to singletons, the likelihood of stillbirths and early neonatal deaths among twins was 1.9 and 6.5 times greater, respectively. 2) The proportion of twins among early neonatal deaths tended to decrease, probably because of improvements in prenatal and perinatal care. 3) The critical period for early neonatal deaths in singletons and twins lasted for the three first days after birth. 4) The incidence of perinatal deaths among twins was highest among MM pairs, followed by FF pairs, and lowest among MF pairs. 5) There was a trend towards a decrease in the annual rate of early neonatal deaths among both singletons and twins, and of stillbirths among singletons, the latter being more conspicuous among females. 6) The sex ratio of singletons was practically stable among living newborns, but showed strong cyclic variation among early neonatal deaths, and a tendency to increase among stillbirths. Twins who died in the first week, as well as living twins showed a strong increase in their sex ratio from 1984 to 1996. 7) The mean gestational age of singletons was highest among living newborns followed by stillbirths, and was lowest among early neonatal deaths. The mean gestational age of living twins was higher than that of early neonatal deaths, but not different from that of stillbirths. 8) The mean birth weight of singletons and twins was highest among living newborns, followed by stillbirths, and lowest among early neonatal deaths. 9) Apgar scores > or = 7 obtained five minutes after birth are inadequate as a reliable indicator of the clinical condition of the newborn, since almost half of the early neonatal deaths had 5-min Apgar scores varying from 7 to 10.
9
Hernández, F., A. Y. Lujano Negrete, C. M. Skinner Taylor, L. Pérez Barbosa, E. Barriga-Maldonado, R. A. Rodriguez Chavez, L. G. Espinosa Banuelos, R. Moyeda Martinez, G. Figueroa-Parra, and D. Á. Galarza-Delgado. "AB0843 OBSTETRIC AND PERINATAL OUTCOMES IN MEXICAN WOMEN WITH RHEUMATIC DISEASES." Annals of the Rheumatic Diseases 80, Suppl 1 (May 19, 2021): 1445–46. http://dx.doi.org/10.1136/annrheumdis-2021-eular.3718.
Full textAbstract:
Background:Rheumatic diseases (RD) are more frequent among women of childbearing age. Adverse events during pregnancy in RDs have been frequently reported, leading some women to avoid pregnancy. “CEER” is an outpatient clinic in Monterrey, Nuevo Leon, Mexico, that was created for pregnant women with RD.Objectives:The objective is to describe pregnancy outcomes in patients with RD surveilled at a rheumatology outpatient clinic.Methods:A single-center retrospective study of women with RD at CEER between 2017 and 2020 was conducted. Clinical features and maternal, fetal and neonatal outcomes were retrospectively collected. The rate of adverse perinatal outcomes (APO) was compared with the tertiary referral center´s general obstetric population (GOP). All data was retrieved from clinical files.Results:Overall, 62 pregnancies in women with RD were recorded. The median maternal age at conception was significantly higher in pregnancies with RD than GOP (29 [24-35] years old vs 23 [19-28] years old, p<0.001).The odds of preterm delivery were increased among pregnancies with RD (OR 1.85, 95% CI 1.03-3.30, p=0.038). Other APO are summarized in Table 1. Rheumatoid arthritis (RA) was the leading diagnosis followed by systemic erythematosus lupus (SLE) and antiphospholipid syndrome (APS).Cesarean sections were recorded in 41 pregnancies in RD group, more frequent than in GOP (66.1% vs 50.8%, p=0.016). Figure 1 shows the distribution of indications for cesarean sections, the two leading indications were previous cesarean section (43.9%) and Nonreassuring fetal heart rate pattern (19.5%) Pregnancies with RD appeared to have frequent, emergency cesarean sections and preterm deliveries compared with GOP (12.9% vs 15.9%, p=0.02 and 23.7% vs 12.2%, p=0.006, respectively).Conclusion:Pregnancies with RD were at increased risk for APO. Women of this population should be made aware of these risks and be closely monitored by a multidisciplinary team as a high-risk pregnancy.References:[1]Aljary H, Czuzoj-Shulman N, Spence AR, Abenhaim HA. Pregnancy outcomes in women with rheumatoid arthritis: a retrospective population-based cohort study. J Matern Fetal Neonatal Med. 2020;33(4):618-24.[2]Alvarez-Nemegyei J, Cervantes-Díaz MT, Avila-Zapata F, Marín-Ordóñez J. [Pregnancy outcomes before and after the onset of rheumatoid arthritis]. Rev Med Inst Mex Seguro Soc. 2011;49(6):599-604.[3]Davutoğlu EA, Ozel A, Yilmaz N, Madazli R. Pregnancy outcome in 162 women with rheumatic diseases: experience of a university hospital in Turkey. Arch Gynecol Obstet. 2017;296(6):1079-84.[4]Harris N, Eudy A, Clowse M. Patient-Reported Disease Activity and Adverse Pregnancy Outcomes in Systemic Lupus Erythematosus and Rheumatoid Arthritis. Arthritis Care Res (Hoboken). 2019;71(3):390-7.[5]Ideguchi H, Ohno S, Uehara T, Ishigatsubo Y. Pregnancy outcomes in Japanese patients with SLE: retrospective review of 55 pregnancies at a university hospital. Clin Rev Allergy Immunol. 2013;44(1):57-64.Table 1.Pregnant outcome, maternal, fetal and neonatal adverse eventsRD (n=62)GOP (n=31254)OR (CI 95%)pPregnancy outcomePregnancy lossa6 (9.68)1560 (4.99)1.94 (0.84-4.49)0.122Live birthsa60 (90.9)29694 (95)0.96 (0.67-1.35)0.8Gestational age,median (IQR) (weeks)b37.6 (37-39)39 (38-40.2)-<0.001Birth weight,mean (CI) (Kg)c2831.6(2677.4-2985.8)3022.2(2986.8-3057.6)-0.007Maternal adverse eventsPreterm deliveries(<37 weeks)a14 (23.7)3821 (12.2)1.85 (1.03-3.3)0.038<34 weeksa3 (5.1)1065 (3.4)1.42 (0.45-4.53)0.553Gestational diabetesa4 (6.5)1406 (4.5)1.43 (0.52-3.95)0.485Preeclampsiaa5 (8.1)2471 (7.89)1.02 (0.41-2.54)0.97Postpartum hemorrhagea0930 (2.97)0.27 (0.017-4.35)0.355Emergency cesarean sectiona8 (12.9)1844 (5.9)2.19 (1.05-4.57)0.037Fetal adverse eventsMiscarriagesa3 (4.8)663 (2.12)2.28 (0.71-7.29)0.164Stillbirthsa3 (4.8)897 (2.87)1.69 (0.53-5.38)0.377Congenital abnormalitiesa4 (6.5)1094 (3.5)1.84 (0.67-5.08)0.237an,%bIQR, interquartile range (25th–75th percentile)cCI, confidence interval (95%)Disclosure of Interests:None declared
10
Trevisanuto, Daniele, Camilla Gizzi, Luigi Gagliardi, Stefano Ghirardello, Sandra Di Fabio, Artur Beke, Giuseppe Buonocore, et al. "Neonatal Resuscitation Practices in Europe: A Survey of the Union of European Neonatal and Perinatal Societies." Neonatology 119, no. 2 (2022): 184–92. http://dx.doi.org/10.1159/000520617.
Full textAbstract:
<b><i>Background:</i></b> We aimed to evaluate the policies and practices about neonatal resuscitation in a large sample of European hospitals. <b><i>Methods:</i></b> This was a cross-sectional electronic survey. A 91-item questionnaire focusing on the current delivery room practices in neonatal resuscitation domains was individually sent to the directors of 730 European neonatal facilities or (in 5 countries) made available as a Web-based link. A comparison was made between hospitals with ≤2,000 and those with >2,000 births/year and between hospitals in 5 European areas (Eastern Europe, Italy, Mediterranean countries, Turkey, and Western Europe). <b><i>Results:</i></b> The response rate was 57% and included participants from 33 European countries. In 2018, approximately 1.27 million births occurred at the participating hospitals, with a median of 1,900 births/center (interquartile range: 1,400–3,000). Routine antenatal counseling (<i>p</i> < 0.05), the presence of a resuscitation team at all deliveries (<i>p</i> < 0.01), umbilical cord management (<i>p</i> < 0.01), practices for thermal management (<i>p</i> < 0.05), and heart rate monitoring (<i>p</i> < 0.01) were significantly different between hospitals with ≤2,000 births/year and those with >2,000 births/year. Ethical and educational aspects were similar between hospitals with low and high birth volumes. Significant variance in practice, ethical decision-making, and training programs were found between hospitals in 5 different European areas. <b><i>Conclusions:</i></b> Several recommendations about available equipment and clinical practices recommended by the international guidelines are already implemented by centers in Europe, but a large variance still persists. Clinicians and stakeholders should consider this information when allocating resources and planning European perinatal programs.
11
Singh, Sukhdip, Shagufta Y. Chaudry, Amy L. Phelps, and Manuel C. Vallejo. "A 5-Year Audit of Accidental Dural Punctures, Postdural Puncture Headaches, and Failed Regional Anesthetics at a Tertiary-Care Medical Center." Scientific World JOURNAL 9 (2009): 715–22. http://dx.doi.org/10.1100/tsw.2009.94.
Full textAbstract:
Obstetric anesthesia-related complications occur as a result of labor epidural or spinal placement. The purpose of this continuous quality-improvement audit was to review the occurrence of accidental dural punctures (ADPs), postdural puncture headaches (PDPHs), and failed regional anesthetics at an academic tertiary-care medical center over a 5-year period. Obstetric anesthesia complications contained in three databases consisting of ADPs, PDPHs, and failed regional anesthetics were matched to a perinatal database, with no complications serving as controls. Of the 40,894 consecutive parturients, there were 765 documented complications. Complication rates were 0.73% (95% CI: 0.65–0.82) for ADP, 0.49% (95% CI: 0.43–0.56) for PDPH, and 0.65% (95% CI: 0.57–0.73) for failed regional anesthetic. When compared to the no complication group, factors associated with obstetric anesthesia complications included increased weight and BMI (p< 0.01), epidural block (p< 0.01), and vaginal delivery (p< 0.01).
12
Strunk, Tobias, Ashok Buchiboyina, Mary Sharp, Elizabeth Nathan, Dorota Doherty, and Sanjay Patole. "Implementation of the Neonatal Sepsis Calculator in an Australian Tertiary Perinatal Centre." Neonatology 113, no. 4 (2018): 379–82. http://dx.doi.org/10.1159/000487298.
Full text
13
An, Hongmin, Wei Zheng, Qinghua Zhu, and Haiyan Wen. "Retrospective study of intrapartum fever in term pregnancies and adverse obstetric and neonatal outcomes." PeerJ 10 (October 27, 2022): e14242. http://dx.doi.org/10.7717/peerj.14242.
Full textAbstract:
Background Intrapartum fever is a well-known predisposing factor for severe perinatal outcomes. Herein, we explored the intrapartum features, obstetric outcomes, and neonatal outcomes in relation to the extent of intrapartum fever via three group analyses. Methods A retrospective cohort analysis consisting of 575 term, singleton live births in one medical center from January 1st to December 31st, 2020 was carried out. Parturients who had experienced a maximal intrapartum fever of <38.0 °C were compared with two sub-groups of parturients who had experienced respective maximal fevers of 38.0–38.9 °C and ≥39.0 °C. We computed the adjusted risks for adverse perinatal outcomes via multiple logistic regression models to control for confounders. Results There were statistically remarkable differences among the three groups in 13 items including body mass index, epidural, and WBC before delivery (p < 0.05). In contrast with intrapartum fevers of 37.5–37.9 °C, intrapartum fevers of 38.0–38.9 °C were linked to an elevated risk of neonatal sepsis and neonatal intensive care unit admission with an odds ratio (OR) of 4.28 (95% CI 2.162–8.479) and 1.73 (95% CI 1.125–2.666), nonetheless, the relationship was remarkably higher for intrapartum fever ≥39.0 °C, with an OR of 6.40 (95% CI 2.450–16.725) and 2.23 (95% CI 1.021–4.854). Additionally, intrapartum fevers of 38.0-38.9 °C and ≥39.0 °C were related to remarkably higher risk for operative deliveries (OR 2.24, 95% CI 1.373–3.648; OR 3.59, 95% CI 1.398–9.226; respectively) and histological chorioamnionitis (OR 3.77, 95% CI 2.261-6.271; OR 19.24, 95% CI 7.385–50.111, respectively). Conclusions Intrapartum fever is an important indicator of adverse perinatal outcomes. The higher the temperature, the higher risk of histological chorioamnionitis, as well as the risk of neonatal sepsis and neonatal intensive care unit admission.
14
Narayanan, S., T. Mohamed, and N. Shankar. "Cord centrality and eccentricity indices of the placenta and their associations." Journal of Morphological Sciences 32, no. 03 (July 2015): 216–18. http://dx.doi.org/10.4322/jms.076414.
Full textAbstract:
Abstract Introduction: The shape of the placenta and position of umbilical cord insertion are associated with perinatal outcome. Cord centrality index (CCI) is a measure of the distance of the umbilical cord insertion from the center of the placenta. Eccentricity index (EI) is a measure of placental shape. Hyrtl's anastomosis (HA) connects the two umbilical arteries and helps to equalize pressure differences. The hypothesis of the study was that there would be a significant correlation between the diameter of HA and the CCI and EI. Materials and Methods: The maximum length, maximum breadth, and distance of the umbilical cord insertion from the center were estimated using Image J software on superior view digital photographs of 88 placentae. The CCI and EI were then calculated. Relevant diameters were measured, and the twist of each umbilical cord was categorized as left and right. Strength of association was estimated using Spearman's correlation, and the independent sample T test for estimating group differences. Results: The mean values of the CCI and EI were 0.41±0.19 and 0.42±0.17. A significant correlation was noted with the diameter of HA between both CCI (0.237, p = 0.029) and EI (-0.252, p = 0.020). No significant differences were observed in the CCI and EI between cords with right and left twist. Conclusion: A greater diameter of the HA is likely be indicative of a higher difference in the blood flow between the umbilical arteries which in turn could influence the placental shape and umbilical cord insertion.
15
Hutchinson, Fiona H., and Mark W. Davies. "Time-to-Delivery after Maternal Transfer to a Tertiary Perinatal Centre." BioMed Research International 2014 (2014): 1–6. http://dx.doi.org/10.1155/2014/325919.
Full textAbstract:
Objectives. To determine, in women transferred antenatally for acute admission with high risk pregnancies, the numbers who deliver, the average time from transfer to delivery, and whether the reason for transfer influences the time-to-delivery.Methods. A retrospective analysis of time-to-delivery was performed in a population of women transferred to the Royal Brisbane and Women’s Hospital, QLD. Data were obtained from the hospital obstetric, neonatal, and admission databases.Results. A total of 941 women were transferred antenatally with high risk pregnancies where delivery was deemed potentially imminent. Of these 821 (87%) delivered at RBWH. The remaining 120 women (13%) were discharged prior to delivery and then delivered elsewhere. Of the 821 maternal transfers that delivered, the median time to delivery was 24.4 hrs. There were 43% who delivered within 24 hours of admission and 29% who either delivered after 7 days or delivered elsewhere. Most transfers for fetal abnormality delivered in the first 24 hours while most transfers for antepartum haemorrhage and preterm prelabour membrane rupture delivered beyond 24 hours.Conclusion. There are significant differences in time-to-delivery following transfer depending on the reason for transfer and many infants transferredin uterowill not deliver imminently.
16
Prka, Matija, Dubravko Habek, Egon Kruezi, Dunja Plačko-Vršnak, Lidija Srnec, and Kristina Medved. "Association of weather conditions and the day with extreme number of deliveries with spontaneous onset in a tertiary referral perinatal center." Periodicum Biologorum 124, no. 1-2 (November 29, 2022): 63–65. http://dx.doi.org/10.18054/pb.v124i1-2.20829.
Full textAbstract:
Background and purpose: The effect of weather on people’s well-being and health has been previously noticed and has been a subject of interest for medical professionals and laypeople throughout human history. There are many studies connecting gynecology and obstetrics with weather, some of them investigating the weather and physiological processes such as onset of labor.Materials and methods: In this paper we tried to find relationship between weather conditions and the day with extreme number of deliveries with spontaneous onset (contractions and/or rupture of membranes) in a tertiary referral perinatal center. It is still debatable whether we could connect the weather conditions with actual childbirth.Results: A case analysis shows that there could be a connection between the development of the weather situation and the extreme number of deliveries with spontaneous onset.Conclusion: Unfavorable biometeorological conditions were the result of weather conditions that affect people. In our case there was strong cold advection during the analyzed period, especially on the day with an extreme number of deliveries with spontaneous onset, and significant drop of barometric pressure.
17
Vasiljevic, Milena, Dejan Nesic, Stasa Krasic, Sanja Ninic, Sergej Prijic, Milika Asanin, Sanja Stankovic, et al. "Correlation between echocardiographic findings and biochemical markers in term newborns with moderate to severe perinatal asphyxia." Archives of Biological Sciences 73, no. 2 (2021): 175–83. http://dx.doi.org/10.2298/abs210121012v.
Full textAbstract:
Perinatal asphyxia (PA) is a condition characterized by a gas exchange disorder due to a lack of blood flow or gas exchange, with potential multiorgan dysfunction. Our study aimed to determine the correlation between biochemical markers and echocardiography findings in a group of asphyxiated newborns. The prospective cohort study included 120 neonates (52/120 with PA) treated at a tertial referral pediatric center, from 2012 to 2014. A moderate-strong positive correlation was recorded between the transtricuspid pressure gradient (TRPG) and serum lactate, and between TRPG and NT-proBNP in the PA group (P<0.001) on the 1st day of life. A moderate positive correlation was found between NT-proBNP, lactate and troponins on one side, and TRPG on the other in the PA group after the 2nd measurement. Multinomial regression analysis showed that the lactate level was an independent factor for survival on the 1st (odds ratio (OR) 41.3, 95% confidence interval (CI) 2.14-797.1) and 3rd (OR 136.4, 95% CI 2.27-8206.7) days. Our research confirmed a significant correlation between echocardiographic and biochemical parameters of the myocardial lesion and cardiac function. Due to their complementarity, the use of the biochemical and echocardiographic parameters may be conditioned by their availability.
18
Yu, VY. "Neonatal consequences of placental and membrane dysfunction." Reproduction, Fertility and Development 3, no. 4 (1991): 431. http://dx.doi.org/10.1071/rd9910431.
Full textAbstract:
Early amnion rupture is a sporadic event that results in mechanical teratogenesis due to amniotic-band disruption and/or compression. It may cause abortion or stillbirth, craniofacial clefts, and cerebral, body wall and limb/skeletal defects. Prolonged and premature rupture of membranes and oligohydramnios result in the dry-lung syndrome and pulmonary hypoplasia. The risk of chorioamnionitis is also increased, with serious consequences to the fetus and neonate. Placental lesions are associated with fetal growth retardation, preterm birth, fetal malformations and other neonatal disorders (congenital infections, erythroblastosis, alpha thalassaemia). In particular, the impact of extremely preterm births on perinatal mortality rates and health costs is substantial. The 1-year survival rate of singleton infants born at the Monash Medical Centre was 10% at a gestation period of 23 weeks, 37% at 24 weeks, 42% at 25 weeks, 61% at 26 weeks and 78% at 27 weeks (11% at birthweights of 500-599 g, 30% at 600-699 g, 55% at 700-799 g and 71% at 800-899 g). Proven measures to minimize the neonatal consequences of extremely preterm delivery include in utero transfer of at-risk fetuses to a perinatal centre and antepartum corticosteroids. Research into the pathophysiological basis of placental and membrane dysfunction may help reduce the prematurity rate.
19
Mailath-Pokorny, Mariella, Stephan Polterauer, Katharina Worda, Stephanie Springer, and Dieter Bettelheim. "Isolated Short Fetal Femur Length in the Second Trimester and the Association with Adverse Perinatal Outcome: Experiences from a Tertiary Referral Center." PLOS ONE 10, no. 6 (June 5, 2015): e0128820. http://dx.doi.org/10.1371/journal.pone.0128820.
Full text
20
Toboso Silgo, Leonie, Sara Cruz-Melguizo, María Luisa de la Cruz Conty, María Begoña Encinas Pardilla, María Muñoz Algarra, Yolanda Nieto Jiménez, Alexandra Arranz Friediger, and Óscar Martínez-Pérez. "Screening for Vaginal and Endocervical Infections in the First Trimester of Pregnancy? A Study That Ignites an Old Debate." Pathogens 10, no. 12 (December 10, 2021): 1610. http://dx.doi.org/10.3390/pathogens10121610.
Full textAbstract:
Objectives: Vaginal and endocervical infections are considered a global health problem, especially after recent evidence of their association with preterm delivery and other adverse obstetric outcomes. Still, there is no consensus on the efficacy of a screening strategy for these infections in the first trimester of pregnancy. This study evaluated their prevalence and whether screening and treatment resulted as effective in reducing pregnancy and perinatal complications. Methods: A single-center prospective observational study was designed; a sample size of 400 first-trimester pregnant women was established and they were recruited between March 2016–October 2019 at the Puerta de Hierro University Hospital (Spain). They were screened for vaginal and endocervical infections and treated in case of abnormal flora. Pregnancy and delivery outcomes were compared between abnormal and normal flora groups by univariate analysis. Results: 109 patients had an abnormal flora result (27.2%). The most frequently detected infection was Ureaplasma urealyticum (12.3%), followed by Candida spp. (11.8%), bacterial vaginosis (5%), Mycoplasma hominis (1.2%) and Trichomonas vaginalis (0.8%). Patients with abnormal flora had a 5-fold increased risk of preterm premature rupture of membranes (5.3% vs. 1.1% of patients with normal flora, Odds Ratio 5.11, 95% Confidence Interval 1.20–21.71, p = 0.028). No significant differences were observed regarding preterm delivery or neonatal morbidity. Conclusions: Considering the morbimortality related to prematurity and that the results of our study suggest that the early treatment of abnormal flora could improve perinatal outcomes, the implementation of a screening program during the first trimester should be considered.
21
Fruchtman, Yariv, Miri Ben harosh, Joseph Kapelushnik, Julia Mazar, Gili Kenet, and Nurit Rosenberg. "Factor VII Deficiency in the Negev - a 10 Years' Experience of One Tertiary Center." Blood 126, no. 23 (December 3, 2015): 4695. http://dx.doi.org/10.1182/blood.v126.23.4695.4695.
Full textAbstract:
Abstract Inherited factor VII (FVII) deficiency is the most common among the autosomal recessive rare bleeding disorders, with an estimated prevalence of 1:300,000 in European countries. Affected individuals display a wide range of clinical phenotypes, ranging from mild non spontaneous bleeding to life threatening (i.e. central nervous system[CNS] bleeding, gastrointestinal [GI] bleeding or haemarthrosis), whereas up to one-third of individuals with a FVII deficiency are asymptomatic and are mainly diagnosed during family studies or after screening for surgery. Unfortunately, the residual activity of FVII does not predict the individual propensity to bleed, and even in individuals with the same mutation, differences in clotting phenotypes can be seen. As our tertiary center serves a unique population in the Negev, we aimed at studying the prevalence and phenotype of FVII deficiency within the last decade. Methods: We searched all electronic records for the last 10 years depicting rare bleeding disorders by ICD 9 code - 2863 and compared them to the hematologic record of factor VII deficiency depicted in our lab - 50% or less activity. Patients with any record of genetic diagnosis, were compared with clinical findings. Results: The population in the Negev is estimated as 700000 people Most of them are Jewish and 150000 of them are Arab-Bedouins. We found 800 records of rare bleeding disorders (ICD 9-2863), Including 200 with FVII deficiency - 100/200 had FVII levels below 50%. Most (90%) of cases were of Jewish origin (mostly oriental Jews) and only 10% were Arab- Bedouins. Forty patients were asymptomatic with 50-30% FVII activity and 20 patients with 30-10% FVII activity were either asymptomatic or presented with mild bleeding diathesis. Out of 23 cases with lower than 10% FVII activity, 7 were symptomatic and suffered severe life threatening bleedings (2 infant died of perinatal ICH. Five families (3 Bedouin and 2 oriental Jews) were identified with severe FVII deficiencies. The 4 Bedouin patients were identified to be homozygous to unique mutation. Interestingly, most medical records depicted FVII deficiency were of women studies due to fertility problems. Conclusions: The prevalence of FVII deficiency depicted in the Negev is much higher in comparison to literature reports (200/700000) Severe FVII deficiency was found in 23: 700000, consistent with 1: 30000 prevalence. As patients are highly variable, in order to "tailor" treatments according to disease severity, new directions should be pursued to identify those with the most severe phenotypes. Disclosures Kenet: Bayer, Novo Nordisk: Other: Advisory Boards, Speakers Bureau; Opko Biologics: Consultancy, Other: Advisory Boards; BPL; Baxelta: Research Funding; Pfizer: Honoraria.
22
Nair, Jayasree, Rachel Longendyke, and Satyan Lakshminrusimha. "Necrotizing Enterocolitis in Moderate Preterm Infants." BioMed Research International 2018 (October 10, 2018): 1–6. http://dx.doi.org/10.1155/2018/4126245.
Full textAbstract:
Necrotizing enterocolitis (NEC) is a devastating morbidity usually seen in preterm infants, with extremely preterm neonates (EPT ≤28 weeks) considered at highest risk. Moderately preterm infants (MPT 28–34 weeks) constitute a large percentage of NICU admissions. In our retrospective data analysis of NEC in a single regional perinatal center, NEC was observed in 10% of extremely EPT and 7% of MPT, but only 0.7% of late-preterm/term admissions. There was an inverse relationship between postnatal age at onset of NEC and gestational age at birth. Among MPT infants with NEC, maternal hypertensive disorders (29%) and small for gestational age (SGA-15%) were more common than in EPT infants (11.6 and 4.6%, resp.). Congenital gastrointestinal anomalies were common among late preterm/term infants with NEC. SGA MPT infants born to mothers with hypertensive disorders are particularly at risk and should be closely monitored for signs of NEC. Identifying risk factors specific to each gestational age may help clinicians to tailor interventions to prevent NEC.
23
Suzuki, Shunji. "Relation between delivery mode and maternal mental status one month after delivery at a perinatal center in Japan: A cross-sectional study." F1000Research 8 (October 27, 2022): 1755. http://dx.doi.org/10.12688/f1000research.20677.4.
Full textAbstract:
Background: Maternal mental status has been thought to be affected by the delivery modes. We examined the relation between delivery modes and the mental status of women who delivered at our institute in Japan. Methods: Data were collected from the medical charts of 643 primiparous women without a history of mental disorders who delivered singleton babies and underwent a 1-month postpartum check-up at our institute from September 2018 to June 2019. The maternal mental status was examined based on the scores of the Edinburgh Postnatal Depression Scale (EPDS) and the Mother-Infant Bonding Scale (MIBS). Results: The rate of high scores of the EPDS and the MIBS in women choosing elective cesarean section were higher than in women with vaginal delivery and emergency cesarean section. Conclusion: Mental health care may be necessary for women choosing elective cesarean section.
24
Kasahara, Kyoko, Tetsuo Ono, Asuka Higuchi, Daisuke Katsura, Kaori Hayashi, Shinsuke Tokoro, Shunichiro Tsuji, Fuminori Kimura, and Takashi Murakami. "Smoking during Pregnancy Is a Predictor of Poor Perinatal Outcomes in Maternal Anorexia Nervosa: A Case Series and Single-Center Cross-Sectional Study in Japan." Tohoku Journal of Experimental Medicine 250, no. 4 (2020): 191–200. http://dx.doi.org/10.1620/tjem.250.191.
Full text
25
Bhatt, Dilip R., Nirupa Reddy, Reynaldo Ruiz, Darla V. Bustos, Torria Peacock, Roman-Angelo Dizon, Sunjeeve Weerasinghe, David X. Braun, and Rangasamy Ramanathan. "Perinatal quality improvement bundle to decrease hypothermia in extremely low birthweight infants with birth weight less than 1000 g: single-center experience over 6 years." Journal of Investigative Medicine 68, no. 7 (July 19, 2020): 1256–60. http://dx.doi.org/10.1136/jim-2020-001334.
Full textAbstract:
Normothermia (36.5°C–37. 5°C) at the time of admission to the neonatal intensive care unit (NICU) in extremely low birthweight (ELBW) infants (birth weight <1000 g) is associated with decreased morbidity and mortality, decreased length of stay and hospital costs. We designed a thermoregulation bundle to decrease hypothermia (<36.5°C) in ELBW infants with a multidisciplinary perinatal quality improvement initiative that included the following key interventions: dedicated delivery room (DR)/operating room (OR) for all preterm deliveries of ≤32 weeks with DR/OR temperature set 24/7 at 74°F by the hospital engineering staff, use of exothermic mattress, preheated radiant warmer set at 100% for heat prior to delivery, servo-controlled mode after the neonate is placed on the warmer, and use of plastic wrap, head cap and warm towels. A total of 200 ELBW infants were admitted to our NICU between January 1, 2014 and December 31, 2019. Hypothermia (<36.5°C) occurred in 2.5% of infants, normothermia (36.5°C–37.5°C) in 91% of infants and transitional hyperthermia (>37.5°C) in 6.5% of ELBW infants. No case of moderate hypothermia (32°C–36°C) was seen in our infants. Our target rate of less than 10% hypothermia was reached in ELBW infants over the last 2 years with no cases of moderate hypothermia in 6 years. Eliminating hypothermia among ELBW remains a challenge and requires team effort and continuous quality improvement efforts.
26
Alfsen, G. Cecilie, Jacek Gulczyński, Ivana Kholová, Bart Latten, Javier Martinez, Myriam Metzger, Katarzyna Michaud, et al. "Code of practice for medical autopsies: a minimum standard position paper for pathology departments performing medical (hospital) autopsies in adults." Virchows Archiv 480, no. 3 (December 10, 2021): 509–17. http://dx.doi.org/10.1007/s00428-021-03242-y.
Full textAbstract:
AbstractThe medical autopsy (also called hospital or clinical autopsy) is a highly specialised medical procedure, which requires professional expertise and suitably equipped facilities. To ensure high standards of performance, the Working Group of Autopsy Pathology of the European Society of Pathology (ESP) suggests a code of practice as a minimum standard for centres performing medical autopsies. The proposed standards exclusively address autopsies in adults, and not forensic autopsies, perinatal/or paediatric examinations. Minimum standards for organisation, standard of premises, and staffing conditions, as well as minimum requirements for level of expertise of the postmortem performing specialists, documentation, and turnaround times of the medical procedure, are presented. Medical autopsies should be performed by specialists in pathology, or by trainees under the supervision of such specialists. To maintain the required level of expertise, autopsies should be performed regularly and in a number that ensures the maintenance of good practice of all participating physicians. A minimum number of autopsies per dedicated pathologist in a centre should be at least 50, or as an average, at least one autopsy per working week. Forensic autopsies, but not paediatric/perinatal autopsies may be included in this number. Turnaround time for final reports should not exceed 3 weeks (14 working days) for autopsies without fixation of brain/spinal cord or other time-consuming additional examinations, and 6 weeks (30 working days) for those with fixation of brain/spinal cord or additional examinations.
27
Kukawczynska-Noczynska, Joanna, Rita Suchanska, and Marta Berghausen-Mazur. "Echocardiographic ultrasound screening assessment of the circulatory system of newborns delivered at basic level perinatal care centers." Advances in Clinical and Experimental Medicine 28, no. 12 (December 17, 2019): 1691–95. http://dx.doi.org/10.17219/acem/110327.
Full text
28
Shi, Wenhao, Wei Zhang, Na Li, Xia Xue, Chen Liu, Pengfei Qu, Juanzi Shi, and Chen Huang. "Comparison of perinatal outcomes following blastocyst and cleavage-stage embryo transfer: analysis of 10 years’ data from a single centre." Reproductive BioMedicine Online 38, no. 6 (June 2019): 967–78. http://dx.doi.org/10.1016/j.rbmo.2018.12.031.
Full text
29
Melekoglu, Rauf, Sevil Eraslan, Ebru Celik, and Yavuz Simsek. "Perinatal and Neonatal Outcomes of Patients Who Were Diagnosed with Neural Tube Defect in Midtrimester Fetal Ultrasound Scan and Refused Request for Termination of Pregnancy." BioMed Research International 2016 (2016): 1–6. http://dx.doi.org/10.1155/2016/6382825.
Full textAbstract:
Objectives. In this study, we aimed to demonstrate the perinatal and neonatal outcomes of patients who were diagnosed with neural tube defect (NTD) in the midtrimester fetal ultrasound scan and refused the request for termination of pregnancy. Material and Methods. The records of 69 patients, for whom NTD was detected in the midtrimester fetal ultrasound scan and who preferred the continuation of the pregnancy after comprehensive counselling about the possible prognosis and treatment options during the period between January 2011 and February 2016, were reviewed retrospectively. Results. Of these patients, 66.7% were 25–35 years old; 95.7% were multiparous; and 1.4% had a history of a fetus having NTD in previous pregnancies. There were 7 (10.1%) neonatal deaths in these patients. Meningomyelocele closure procedure was the most performed surgery in the postnatal period (92%). Of these patients, 30.7% had paraplegia; 51.6% had neurogenic bladder; and 6.4% had infections due to surgery. Conclusion. The results of this study demonstrated perinatal and neonatal outcomes of fetuses with NTD who were not terminated by the preference of the family in midtrimester. The experience of our centre would be beneficial as a tool for nondirective counselling of these patients when considering the antenatal/postnatal care options and postnatal prognosis.
30
Hage, Aglaia, Naomi C. A. Juliana, Leonie Steenhof, Ralph R. Voigt, Servaas A. Morré, Elena Ambrosino, and Nurah M. Hammoud. "Frequency of Chlamydia trachomatis and Neisseria gonorrhoeae in Patients with Imminent Preterm Delivery on the Island of Curaçao." Pathogens 11, no. 6 (June 9, 2022): 670. http://dx.doi.org/10.3390/pathogens11060670.
Full textAbstract:
Sexually transmitted infections are one of the important risk factors for preterm delivery, which is among the important contributors to perinatal morbidity and mortality. The aim of this study was to assess the prevalence of Chlamydia trachomatis and Neisseria gonorrhoeae infections in women with imminent preterm delivery in Curaçao, an island of the Dutch Caribbean. All women from Curaçao with either preterm premature rupture of the membranes or preterm labor, common indications of imminent preterm delivery, and presenting at the Curaçao Medical Center between 15 November 2019 and 31 December 2020, were included in this single cohort study. Data were retrospectively collected from medical records. The presence of Chlamydia trachomatis and Neisseria gonorrhoeae was assessed by Cepheid GeneXpert ® (Xpert) CT/NG assay (Sunnyvale, CA, USA). In the included cohort, the prevalence of Chlamydia trachomatis infection was 15.5% and of Neisseria gonorrhoeae infection was 2.1%. All patients infected with Neisseria gonorrhoeae were co-infected with Chlamydia trachomatis. The prevalence of Chlamydia trachomatis and Neisseria gonorrhoeae infections in patients with imminent preterm delivery in Curaçao is high. It is recommended to test all patients with imminent preterm delivery for these sexually transmitted infections and possibly consider testing all women in early pregnancy on the island.
31
Gibson, Elizabeth. "Biomedical Applications in Primatology." Practicing Anthropology 8, no. 1-2 (January 1, 1986): 6–7. http://dx.doi.org/10.17730/praa.8.1-2.7w042p8453x06jv3.
Full textAbstract:
Studies of the biology and behavior of nonhuman primates have played an integral role in biomedical research, from the development of models of human disease, injury, and brain function, to toxicity testing and the evaluation of novel environments. In most situations primatologists are consulted for their expertise in the anatomy, physiology, genetics, behavior, and ecology of human and nonhuman primates. Opportunities for applied primatologists as consultants, salaried research scientists, data analysts, and administrators exist in a wide range of nonacademic settings including medical centers, nonprofit research organizations, commercial animal supply houses, government agencies, museums, and zoos. Several broad topical areas are usually of interest: 1) behavior, including observation and measurement of psychological and social variables in projects such as pharmacological/toxicological testing, child abuse, and surgery; 2) nutrition, including causes, effects, and prevention of dietary deficiencies and obesity, and their interaction with disease; 3) reproduction, including documentation and measurement of sexual cycles, fertility, pregnancy, perinatal studies, and birth control; 4) human chronic and infectious disease models; and 5) miscellaneous studies on genetics, exercise physiology, aging, artificial limbs, organ transplants, and vehicular safety.
32
Xu, Mei-Yan, Yan-Jun Guo, Li-Juan Zhang, and Qing-Bin Lu. "Effect of individualized weight management intervention on excessive gestational weight gain and perinatal outcomes: a randomized controlled trial." PeerJ 10 (March 8, 2022): e13067. http://dx.doi.org/10.7717/peerj.13067.
Full textAbstract:
It is unclear whether weight management is still effective for pregnant women with excessive weight gain in the second or third trimester in China. This study adopted individualized weight management intervention for pregnant women with abnormal weight gain in the second or third trimester, to analyze the effect of intervention by observing the gestational weight gain and perinatal outcomes. This randomized controlled trial was performed at Aerospace Center Hospital. The obstetrician determined whether the pregnant women gained too much weight in the second or third trimester according to the Institute of Medicine guidelines, and randomly divided the pregnant women who gained too much weight in the second or third trimester into the intervention group or the control group according to the inclusion and exclusion criteria. The pregnant women in the intervention group and in the control group all received routine prenatal examination and diet nutrition education by the doctors in the Department of Obstetrics and Gynecology. The intervention group underwent individualized weight management, including individualized diet, exercise, psychological assessment, cognitive intervention and continuous communication, the whole process is tracked and managed by professional nutritionists. The obstetrician collected the prenatal examination data and pregnancy outcome data of all enrolled pregnant women. The primary outcome measure was weight gain during pregnancy. A generalized linear model and a logistic regression model were used to compare the outcomes between the two groups. In total, 348 pregnant women participated in this study with 203 in the intervention group and 145 in the control group. The whole gestational weight gain in the intervention group (15.8 ± 5.4 Kg) was lower than that in the control group (17.5 ± 3.6 Kg; adjusted β = − 1.644; 95% CI [−2.660–−0.627]; P = 0.002). The percent of pregnant women with excessive weight gainbefore delivery was 54.2% (110/203) in the intervention group, which was lower than 69.7% (101/145) in the control group (adjusted RR = 0.468; 95% CI [0.284–0.769] P = 0.003). The pregnant women given the individualized weight management intervention from the second to the third trimester experienced less weight gain than that from the third trimester (15.5 ± 5.6 Kg vs. 16.2 ± 5.2 Kg), but without significant difference (P = 0.338). Lower rates of GDM, preeclampsia and gestational hypertension, higher rates of fetal distress and puerperal infection were observed in the intervention group than in the control group (all P < 0.05). Individualized weight management during the second or third trimesters is still beneficial for pregnant women who gain excessive weight and can decrease the associated adverse outcomes.
33
Pangratz-Fuehrer, Susanne, Orsolya Genzel-Boroviczény, Wolfgang Bodensohn, Robin Eisenburger, Janne Scharpenack, Philipp E. Geyer, Johannes B. Müller-Reif, et al. "Cohort profile: the MUNICH Preterm and Term Clinical study (MUNICH-PreTCl), a neonatal birth cohort with focus on prenatal and postnatal determinants of infant and childhood morbidity." BMJ Open 11, no. 6 (June 2021): e050652. http://dx.doi.org/10.1136/bmjopen-2021-050652.
Full textAbstract:
PurposeThe MUNICH Preterm and Term Clinical (MUNICH-PreTCl) birth cohort was established to uncover pathological processes contributing to infant/childhood morbidity and mortality. We collected comprehensive medical information of healthy and sick newborns and their families, together with infant blood samples for proteomic analysis. MUNICH-PreTCl aims to identify mechanism-based biomarkers in infant health and disease to deliver more precise diagnostic and predictive information for disease prevention. We particularly focused on risk factors for pregnancy complications, family history of genetically influenced health conditions such as diabetes and paediatric long-term health—all to be further monitored and correlated with proteomics data in the future.ParticipantsNewborns and their parents were recruited from the Perinatal Center at the LMU University Hospital, Munich, between February 2017 and June 2019. Infants without congenital anomalies, delivered at 23–41 weeks of gestation, were eligible.FindingsFindings to date concern the clinical data and extensive personal patient information. A total of 662 infants were recruited, 44% were female (36% in preterm, 46% in term). 90% of approached families agreed to participate. Neonates were grouped according to gestational age: extremely preterm (<28 weeks, N=28), very preterm (28 to <32 weeks, N=36), late preterm (32 to <37 weeks, N=97) and term infants (>37+0 weeks, N=501). We collected over 450 data points per child–parent set, (family history, demographics, pregnancy, birth and daily follow-ups throughout hospitalisation) and 841 blood samples longitudinally. The completion rates for medical examinations and blood samples were 100% and 95% for the questionnaire.Future plansThe correlation of large clinical datasets with proteomic phenotypes, together with the use of medical registries, will enable future investigations aiming to decipher mechanisms of disorders in a systems biology perspective.Trial registration numberDRKS (00024189); Pre-results.
34
Cruz-Machado, A. R., S. C. Barreira, P. Martins, M. Centeno, C. Araújo, L. Pinto, and S. Capela. "FRI0515 MATERNAL AND PERINATAL OUTCOMES IN WOMEN WITH RHEUMATIC DISEASES – A 10-YEAR EXPERIENCE FROM A PORTUGUESE TERTIARY CENTRE." Annals of the Rheumatic Diseases 79, Suppl 1 (June 2020): 856.2–857. http://dx.doi.org/10.1136/annrheumdis-2020-eular.2125.
Full textAbstract:
Background:Pregnant women with rheumatic diseases (RD) represent a population at a higher risk for adverse pregnancy outcomes (APO). At our unit, these patients (pts) are surveilled at a high-risk pregnancy clinic, by both rheumatologists and obstetricians.Objectives:To assess pregnancy outcomes in pts with RD surveilled at our unit over the last decade.Methods:Single-centre observational retrospective study of pregnant women with RD followed at a portuguese tertiary centre between 2009 to 2019.Results:Overall, 353 pregnancies (preg) in 295 pts with RD were managed at our unit. Table 1 summarizes clinical data and the main APO recorded. Systemic lupus erythematous (SLE) was the leading diagnosis followed by spondyloarthritis (SpA) and rheumatoid arthritis (RA). Antiphospholipid syndrome (APS) was diagnosed in 49 (13.9%) preg. We documented 284 (78%) live births (9 twin preg), 32 (10%) miscarriages, 7 (2%) elective abortions, 2 stillbirths (0.6%) and 2 ectopic preg; 35 (10%) of the overall preg were lost to follow up before delivery. Miscarriages occurred predominantly in pts with APS (34%). Fetal growth restriction (FGR) was recorded in 6% of preg, more than 1/3 of those in pts with APS. Preeclampsia (PE) complicated a total of 10 (4%) preg, 3 of those with superimposed HELLP syndrome, with SLE and APS accounting for 60% of the cases. Preterm births (15.5%) occurred mainly in APS, SLE and juvenile idiopathic arthritis (JIA) pts. Neonatal lupus ensued in 3 (3.8%) preg positive for anti-Ro/La antibodies. No neonatal deaths were recorded. SpA and RA represented the diseases which flared the most considering both pregnancy and the postpartum period.Table 1.Pregnancy outcomes by diseaseMain diagnosisN, %Gest age at delivery(weeks)MiscarrFGRPEPreterm birthsFlares in pregFlares in PPSLE116,32.938±2.313/110,11.86/82,7.35/78,6.415/76,21.116/92,17.45/79,6.3SpA60,1739±2.62/55,3.65/44,11.41/45,2.25/40,12.518/40,455/23,21.7RA51,14.439±1.26/49,12.21/35,2.91/33,31/29,3.410/37,277/30,23.3Vasculitis25,7.138±1.81/24,4.21/21,4.80/19,04/21,197/23,30.42/17,11.8Primary APS22,6.238±1.63/22,13.61/17,5.91/16,6.32/16,12.5NANAJIA17,4.838±2.51/17,5.90/12,00/11,04/12,33.32/13,15.41/8,12.5UCTD15,4.239±1.52/15,13.30/11,01/10,101/11,9.10/15,00/15,0Primary Sjögren Syndrome12,3.439±1.40/11,00/9,00/10,01/9,11.11/8,12.50/6,0Others35,9.938±2.34/31,12.92/20,101/18,5.63/18,16.74/27,14.81/22,4.5Total353,10038±2.232/334,9.616/251,6.410/240,4.236/232,15.558/255,22.721/200,10.5Secondary diagnosisAPS2737±2.78/26,30.85/16,31.32/12,16.75/15,33.3NANASjögren Syndrome937±2.51/9,11.11/7,14.30/7,03/6,50NANALegend - gest: gestational; miscarr: miscarriages; NA – not applicable; PP: postpartum; preg: pregnancy; UCTD - Undifferentiated connective tissue disease. Continuous variables are presented as mean±SD. Categorical variables as n/mN, % - modified(m)N stands for total N – (not applicable+missing data); “Others” accounts for diagnosis with N≤6, such as APS non criteria, mixed connective tissue disease, myositis, overlap syndromes, Still’s disease and systemic sclerosis.Conclusion:In pregnant women with RD, it is of vital importance to be aware of the increased risk for APO. In our cohort, APS and SLE were the conditions most associated with APO, while SpA and RA were responsible for most maternal flares. Nevertheless, the majority of these pts, surveilled by a multidisciplinary team, had successful gestations.Disclosure of Interests:None declared
35
Basso, Neusa A. S., Roberto A. A. Costa, Adriano Dias, Claudia G. Magalhães, Marilza V. C. Rudge, and Iracema M. P. Calderon. "Symphysis-Fundal Height Curve in Pregnancies Complicated by Maternal Hyperglycemia: Comparison with Curves of Nondiabetic Pregnant Women." BioMed Research International 2020 (September 1, 2020): 1–10. http://dx.doi.org/10.1155/2020/1908764.
Full textAbstract:
Background. Reference symphysis-fundal height (SFH) curves for pregnancies complicated by maternal hyperglycemia are not available. Objective. To build an SFH curve according to gestational age for pregnant women with hyperglycemia-type 2 diabetes (T2DM), gestational diabetes mellitus (GDM), or mild gestational hyperglycemia (MGH) and compare it with three other curves in use in Brazil. Methods. Prospective cohort study of 422 pregnant women with hyperglycemia attending the Perinatal Diabetes Research Center (PDRC) of Botucatu Medical School, São Paulo State University/UNESP. Between 13 and 41 weeks of pregnancy, 2470 SFH measurements were obtained (mean 5.85 per woman). For the assessment of glycemic control, 2074 glucose level measurements were taken and the glycemic mean (GM) at each gestational week was estimated. Results. GM was adequate (<120 mg/dL) in 94.9% and inadequate (≥120 mg/dL) in 5.1% of the cases. The equation applied for SFH prediction was expressed as SFH=1.082+0.966∗week (r2=84.6%). At visual analysis, P10 and P90 SFH measurements were higher in the study curve than in the three other curves. Statistical analysis confirmed that SFH median values in this study were higher than those in the reference curve of habitual risk pregnancies, especially after 19 weeks of pregnancy. Conclusion. Taking into account that the maternal hyperglycemia was at strict control, our unedited results suggest that the current SFH curve can be a useful tool in prenatal care of T2DM, GDM, and MGH pregnant women.
36
Preethi, Bhuvana, Mala Vijayakrishnan, and Prasanth Nagarajan. "A study of postnatal depression in a tertiary care centre – A prospective observational study." Indian Journal of Obstetrics and Gynecology Research 9, no. 4 (November 15, 2022): 501–5. http://dx.doi.org/10.18231/j.ijogr.2022.096.
Full textAbstract:
Postnatal depression is defined as non-psychotic depressive episodes of mild to major severity which occurs during pregnancy or postpartum. It is one of the most common non obstetric disorders that causes significant morbidity in women during the perinatal period. It is often unrecognized, but an extremely common yet a disorder (100-150 per 100 births) and is prevalent among Indian women up to 19% - 22% as well. The aim of this study is to find out incidence of postnatal depression in Vijaya Hospital, a private tertiary care hospital. This study aims at identifying the incidence of postnatal depression in postnatal mothers in a tertiary care centre using Edinburg Postnatal Depression Scale (EPDS) questionnaire and the risk factors contributing to postpartum depression. The results were incidence of postnatal depression at week one was 40% and week four was 27%.: It is a prospective observational study with a sample size of 100. Postnatal mothers were screened using EPDS questionnaire at one week when they are admitted in hospital and four weeks when they come for postnatal checkup. Women with EPDS score of 13 and above was considered having Postpartum Depression. Age, socioeconomic status, educational status, employment status, type of family, menstrual history, premenstrual syndrome, obstetric score, mode of delivery, planning of pregnancy, relationship with parents, in laws and partner was compared at one week and four weeks.The Primary outcome of the study was to measure the incidence of PPD at week one which was 40% and week four which was 27%. The secondary outcome identified the risk factors contributing to PPD in my study was menstrual history, mode of delivery, relationship with in laws, lack of partner support which was found to be statistically significant. In my study done in a private tertiary care hospital, the cumulative incidence of PPD was 52%. Delivery through Caesarean section, menstrual history and poor relationship with in laws at one week was found to be statistically significant with a p-value of <0.05. Lack of partner support at one week and four weeks were found to be statistically significant with a p- value of < 0.05.
37
Arnold, Lauren, Susan Gennaro, Adrienne Kirby, Marisa Atendido, Marjorie Laverty, and Dorothy Brooten. "The perinatal evaluation center." Journal of Perinatal & Neonatal Nursing 9, no. 1 (June 1995): 45–51. http://dx.doi.org/10.1097/00005237-199506000-00008.
Full text
38
Kutlar, Abdullah, Niren Patel, Celalettin Ustun, Kavita Natarajan, Anand Jillella, Betsy Clair, Ferdane Kutlar, Rosemary Chandler, Steffen E. Meiler, and Kapil N. Bhalla. "LBH589 (panobinostat): A Potential Novel Anti-Switching Therapy." Blood 114, no. 22 (November 20, 2009): 2568. http://dx.doi.org/10.1182/blood.v114.22.2568.2568.
Full textAbstract:
Abstract Abstract 2568 Poster Board II-545 Reversing the perinatal switch from fetal to adult hemoglobin synthesis has been an attractive therapeutic goal for β-hemoglobinopathies such as sickle cell disease (SCD) and β-thalassemia. Fetal hemoglobin (Hb F) inhibits the polymerization of deoxy Hb S (anti-sickling effect) in SCD and ameliorates the globin chain imbalance by compensating for severely diminished or absent β-globin synthesis in β-thalassemia. Different classes of compounds have been used for this purpose; only hydroxyurea (HU), an S-phase specific chemotherapeutic agent, an inhibitor of ribonucleotide reductase, has been FDA approved for use in adults with SCD and is currently in phase III trials for infants and children. Despite the established efficacy of HU in many patients with SCD, there is a need for alternative Hb F inducing agents and therapies; an estimated 30% of patients do not respond to HU therapy. In addition, some patients are intolerant of HU due to a number of side effects. The development of novel, more effective anti-switching agents is hampered by a lack of a clear and complete understanding of the molecular mechanism(s) underlying the perinatal switch from fetal (γ-globin) to adult (β-globin) synthesis despite three decades of intensive research. Nevertheless, it has been established that epigenetic mechanisms such as histone deacetylation and DNA methylation do play an important role in the silencing of the γ-globin genes during the perinatal period. In vitro studies and early phase clinical trials in a small number of patients have provided the proof-of-principle for the efficacy of a number of histone deacetylase (HDAC) inhibitors and hypomethylating agents (DNA methyl transferase I inhibitors). Butyrate derivatives are an example of HDAC inhibitors whose efficacy in inducing Hb F has been proven in both SCD and β-thalassemia. More recently, other HDAC inhibitors (SAHA, Depsipeptide, Trichostatin A) have been shown to induce Hb F synthesis in erythroid cultures. DNMT-1 inhibitors, 5-Azacytidine and decitabine, have also been used in small clinical trials to enhance Hb F production and ameliorate the course of severe SCD. LBH589 (panobinostat, Novartis Pharma) is a pan-HDAC inhibitor that belongs to the hydroxamic acid class of HDAC inhibitors that is currently being investigated in Phase I/II trials in hematologic malignancies and a number of solid tumors. We monitored the Hb composition of 21 patients with relapsed/refractory hematologic malignancies enrolled into a Phase I/b trial of panobinostat conducted at the MCG Cancer Center. Hb quantification was done by a cation exchange HPLC procedure. Eight patients were on panobinostat for 2 months or longer with a starting dose of 40–60 mg PO administered thrice weekly (MWF). Three patients carried a diagnosis of Primary Myelofibrosis and one each had Chronic Lymphocytic Leukemia, Mantle Cell Lymphoma, Multiple Myeloma, Refractory Non-Hodgkins Lymphoma, and Chronic Myelogenous Leukemia-accelerated phase. Of these, 4 patients displayed an increase in Hb F over baseline values. None of the patients had an inherited hemoglobinopathy (SCD or β-thalassemia). The median Hb F was 0.33% at entry (range: 0–2.3) and increased to 1.1% (range 0–17%) at the end of the study period. The maximal response was seen in a patient with Primary Myelofibrosis whose Hb F increased from a pretreatment value of 0.2% to 17.0% over a period of 16 months. Overall, patients who were on panobinostat for longer periods of time (≥ 2 months) had a more pronounced increase in Hb F. The remaining 13 patients were on study drug for <2 months. In studies of other Hb F inducing agents, optimal response is not generally reached in less than 6 months. The slight but significant increase in Hb F in this small group of patients without an underlying hemoglobinopathy is encouraging and provides the rationale for a trial of panobinostat as an anti-switching agent in clinically significant hemoglobinopathies such as SCD and β-thalassemia. This effect will likely be enhanced in patients with hemoglobinopathies given the erythropoietic stress and the selection of RBCs containing Hb F. Studies in transgenic mouse models of SCD and a phase I study in patients with SCD who have failed or intolerant of HU are underway. Disclosures: Kutlar: Novartis Pharmaceuticals, Inc.: Research Funding; Celgene Corporation: Research Funding; HemaQuest Pharmaceuticals, Inc.: Research Funding. Meiler:Celgene Corporation: Research Funding; Novartis Pharmaceuticals, Inc.: Research Funding. Bhalla:Novartis: Honoraria, Research Funding; Merck: Honoraria.
39
Jia, Yuxi, Cong Zhu, Jingcheng Du, Yang Xiang, Yong Chen, Wei Wang, and Cui Tao. "Investigating safety profiles of human papillomavirus vaccine across group differences using VAERS data and MedDRA." PeerJ 7 (August 20, 2019): e7490. http://dx.doi.org/10.7717/peerj.7490.
Full textAbstract:
Background The safety of vaccines is a critical factor in maintaining public trust in national vaccination programs. This study aimed to evaluate the safety profiles of human papillomavirus (HPV) vaccines with regard to the distribution of adverse events (AE) across gender and age, and the correlations across various AEs using the Food and Drug Administration/Centers for Disease Control and Prevention Vaccine Adverse Event Reporting System (VAERS). Methods For analyses, 27,348 patients aged between 9 and 25 years old with at least one AE reported in VAERS between the year of 2006 and 2017 were included. AEs were summarized into two levels: the lower level preferred term (PT) and higher level system organ classes (SOCs) based on the structure of Medical Dictionary for Regulatory Activities (MedDRA). A series of statistical analyses were applied on both levels of AEs. Zero-truncated Poisson regression and multivariate logistic regression models were first developed to assess the rate and risk of SOCs across age groups and genders. Pairwise Pearson correlation analyses and hierarchical clustering analyses were then conducted to explore the interrelationships and clustering pattern among AEs. Results We identified 27,337 unique HPV vaccine reports between 2006 and 2017. Disproportional reporting of AEs was observed across age and gender in 21 SOCs (p < 0.05). The correlation analyses found most SOCs demonstrate weak positive correlations except for five pairs which were negatively correlated: skin and subcutaneous tissue disorders + injury poisoning and procedural complications; skin and subcutaneous tissue disorders + nervous system disorders; Skin and subcutaneous tissue disorders + pregnancy, puerperium and perinatal conditions; nervous system disorders + pregnancy, puerperium and perinatal conditions; pregnancy, puerperium and perinatal conditions + general disorders and administration site conditions. Nervous system disorders had the most AEs which contributed to 12,448 (46%) cases. In the further analyses of correlations between PT in nervous system disorders, the three most strongly correlated AEs were psychiatric disorders (r = 0.35), gastrointestinal disorders (r = 0.215), and musculoskeletal and connective tissue disorders (r = 0.261). We observed an inter-SOCs correlation of the PTs among AE pairs by nervous system disorders/psychiatric disorders/gastrointestinal disorders/musculoskeletal and connective tissue disorders. Conclusions The analyses revealed a different distribution pattern of AEs across gender and age subgroups in 21 SOC level AEs. Correlation analyses and hierarchical clustering analyses further revealed several correlated patterns across various AEs. However, findings from this study should be interpreted with caution. Further clinical studies are needed to understand the heterogeneity of AEs reporting across subgroups and the biological pathways among the statistically correlated AEs.
40
Grigoryev, E. G., L. V. Sereda, and N. I. Ayushinova. "Staged treatment of abdominal sepsis in a puerpera with COVID-19 and pancreatonecrosis after cesarean section: case report." Acta Biomedica Scientifica 7, no. 5-2 (December 10, 2022): 240–46. http://dx.doi.org/10.29413/abs.2022-7.5-2.24.
Full textAbstract:
The aim of the study. Description of the medical history and discussion of treatment tactics in a puerperal woman after a caesarean section against the background of pancreatic necrosis, panmetritis, abdominal sepsis, COVID-19.Material and methods. A 30-year-old pregnant woman (30–31 weeks) was hospitalized in a perinatal center 5 days after the onset of girdle pain in the abdomen and uncontrollable vomiting, which did not bring relief. She had a history of caesarean sections 10 and 5 years ago. Sterile pancreatic necrosis was diagnosed. Successful caesarean section was performed. During the revision of the abdominal cavity, multiple plaques of fatty necrosis, omentobursitis were found in the upper abdomen. The treatment included pancreatic abdominization, cholecystostomy, abdominal drainage. Clinical roentgenologic examination and PCR-test verified COVID-19.Infected pancreatonecrosis developed, complicated with necrotic omentitis, abscess of the omental bursa (Enterococcus faccilis 107 CFU, Acinobacter baumani 106 CFU), abdominal sepsis, successfully treated. During vaginal examination, hemorrhagic discharge appeared (Klebsiella pneumoniae 105 CFU, Pseudomonas aeruginosa 105 CFU). Extirpation of the uterus revealed the defect of the anterior wall, thrombosis of the uterine arteries and veins, peripheral vessels. The patient recovered. The body build index was 26.03 kg/m2 at admission, 18.22 kg/m2 – at discharge, 23.61 kg/ m2 – 3 months later.Conclusion. 1. During the COVID-19 pandemic, pregnant women are often targeted by SARS-CoV-2. Prevention, diagnosis and treatment of coronavirus infection should be carried out according to the recommendations approved by the authorized health organ. 2. In the presented case report, the pathogenesis of complicated sterile pancreatonecrosis, cesarean section, abdominal sepsis were significantly influenced by changes due to organ ischemia in the result of peripheral vessels thrombosis. 3. The severity of the patient’s condition was certainly determined by the miscellaneous microbial profile – association of four agents of aggressive in-hospital infection in high concentration.
41
Vuković Bobić, Mirna, Dubravko Habek, Jasna Čerkez Habek, and Dario Dilber. "Protein S and protein C in preeclamptic pregnant women." Periodicum Biologorum 123, no. 3-4 (July 1, 2022): 95–97. http://dx.doi.org/10.18054/pb.v123i3-4.8671.
Full textAbstract:
Background and purpose: Deficits of protein C and protein S are associated with an increased incidence of thrombotic disorders. The aim of the present study was to determine the levels of the mentioned natural coagulation inhibitors in women with preeclampsia and in a 6-months followup period after delivery.Materials and methods: This case-control clinical study included 55 pregnant women (cases) with preeclampsia and 50 healthy normotensive pregnant women (controls) in tertiary perinatal centre. Protein C levels were determined photometrically using a chromogen substrate, and protein S levels were determined using the clot method and optic detection.Results: There were no significant differences in protein C and protein S levels between women with preeclampsia and healthy pregnant women; however, six months after delivery protein S levels were significantly lower in women with preeclampsia as compared to healthy peers, whereas protein C levels did not differ significantly.Conclusion: Possible long-term cardiovascular morbidity should be assessed in preeclampsia women.
42
Pandey, Shilpa, Rohini Coorg, Sherrill Mohan, and Kevin Kaplan. "0860 Burst Suppression due to Diffuse Encephalopathy." Sleep 45, Supplement_1 (May 25, 2022): A369—A370. http://dx.doi.org/10.1093/sleep/zsac079.854.
Full textAbstract:
Abstract Introduction Burst suppression is a finding on electroencephalography (EEG) associated with a severe encephalopathy associated with coma, severe infantile-onset epilepsy syndromes, hypothermia, or may be medically induced by general anesthesia. It presents as a pattern of alternating high-voltage, 75-250µV, activity separated by periods of amplitude dampening, less than 5µV, of electrical brain activity1. The duration of the burst’s activity is 1-20 seconds while the suppression lasts longer than 10 seconds1. When not medically induced, burst suppression is a known marker of poor prognosis. Report of Cases: An 18-year-old male with cerebral palsy, spastic quadriplegia, and static encephalopathy secondary to hypoxemia ischemic injury in the perinatal period presents with excessive sleepiness during therapy sessions. He was empirically placed on non-invasive ventilatory support with BPAP ST 8/4 cm H2O with a rate of 10 breaths per minute for chronic respiratory failure during sleep. While awake he shows no evidence of hypoxemia or hypercapnia on room air. A polysomnogram was ordered showing moderate obstructive sleep apnea (oAHI 9.73) and central sleep apnea (5.84 events per hour) without hypoxemia (SpO2 nadir 90%), or hypercapnia (TcCO2 max 48 mmHg). The study was scored as REM/NREM as specific sleep architecture was not identified. Diffuse burst suppression was observed. No epileptiform abnormalities were recorded. A MRI of the brain shows diffuse encephalomalacia involving the supratentorial brain parenchyma with volume loss of the cerebellum, the pons, and brain stem. Conclusion The abnormal brain activity noted in our patient is due to underlying encephalomalacia and diffuse brain injury secondary to his perinatal hypoxemic ischemic injury. Despite his significant underlying neurological abnormality, he can maintain adequate ventilation and oxygenation while awake. While asleep, he has moderate obstructive and central sleep apnea without hypoxemia or hypercapnia. This is likely due to the activity of control centers of respiration being spared despite the volume loss noted on the brain MRI. Support (If Any) References:1) Bhattacharyya, Sourya; Biswas, Arunava; Mukherjee, Jayanta; Majumdar, Arun Kumar; Majumdar, Bandana; Mukherjee, Suchandra; Singh, Arun Kumar (1 November 2013). "Detection of artifacts from high energy bursts in neonatal EEG". Computers in Biology and Medicine. 43 (11): 1804–1814.2) Lee, Jaeyun; Song, Woo-Jin; Lee, Hyang-Woon; Shin, Hyun-Chool (2016). "Novel Burst Suppression Segmentation in the Joint Time-Frequency Domain for EEG in Treatment of Status Epilepticus". Computational and Mathematical Methods in Medicine. 2016.
43
Lavanya B, Rashmi Ullagaddi, Pavani M, and K. Srinivas Rao. "Evaluation of serum lactate dehydrogenase as early diagnostic biomarker in pregnancy with preeclampsia and eclampsia." Indian Journal of Obstetrics and Gynecology Research 9, no. 1 (February 15, 2022): 83–87. http://dx.doi.org/10.18231/j.ijogr.2022.016.
Full textAbstract:
Pregnancy is a physiological state associated with many alterations in biochemical, physiological, hematological & immunological processes. Preeclampsia and eclampsia complicate 6-8% of all pregnancies and lead to various maternal and fetal complications. The aim of the present study was to evaluate serum LDH levels in the normal pregnant women and pregnant women with preeclampsia and eclampsia in ante-partum period and to study the correlation of maternal and perinatal outcomes with serum LDH levels.This prospective study was conducted among ANC mothers from 18-35 years with term singleton pregnancy attending OBG OPD and labour room at Navodaya Medical College Hospital & Research Centre, Raichur. After taking informed consent & detailed clinical examination, relevant laboratory investigations were performed. The serum LDH estimated using fully automated ERBA biochemical analyser.In the present study, a total of 200 pregnant women were included, out of which 100 were normal pregnant women which served as control group; remaining 34 (17%) cases were included in pregnancy with eclampsia and 66 (33%) were pregnancy with pre-eclampsia. In 29 cases of study group with Serum LDH in the range of 600-800 IU/L, 08 (27.6%) had severe pre-eclampsia and 18 (62.0%) had eclampsia. Of 34 eclampsia cases, 18(52.9%) had Serum LDH range 600-800IU/L and 14 (41.2%) had serum LDH >800IU/L. The mean Serum LDH in study group was 570.5 IU/L and in control group was 201.5 IU/L. The patients had maternal complications like abruption, PPH, DIC, eclampsia with LDH>600. Neonatal complications like IUGR, fetal distress, neonatal death, LBW, premature birth, IUD were increased with raised LDH. Serum LDH is the earliest marker in blood during hypoxia and oxidative stress. It is raised in cases of pre-eclampsia and eclampsia. Detection of high-risk patients with increased levels of LDH mandates close monitoring, prompt and correct management to decrease both maternal and foetal morbidity and mortality. Estimation of serum Lactate Dehydrogenase can be used as a prognostic marker for preeclampsia and eclampsia.
44
Madiba, Sphiwe, and Unaswi Josiah. "Perceived Stigma and Fear of Unintended Disclosure are Barriers in Medication Adherence in Adolescents with Perinatal HIV in Botswana: A Qualitative Study." BioMed Research International 2019 (December 2, 2019): 1–9. http://dx.doi.org/10.1155/2019/9623159.
Full textAbstract:
Background. Maintaining optimal adherence to antiretroviral treatment (ART) is a challenge for adolescents with perinatally HIV (ALPHIV), and there is little consensus on what factors contribute to adherence in this population. This study assessed self-reported medication adherence among ALPHIV and explored structural factors that hinder or motivate them to adhere. Methods. This qualitative study used in-depth interviews with ALPHIV at the infectious disease control centre of a teaching hospital in Botswana. Thirty adolescents aged 12–19 years who were aware of their HIV status were recruited purposively. Transcribed interviews were analysed using the thematic approach and NVivo data analysis software. Findings. Nonadherence was a problem across age groups and gender. Perceived stigma was a major barrier to ART adherence. The fear of stigma and unintended disclosure were more pronounced in those attending boarding school. The adolescents were not willing to take medication in front of roommates and outside of the home. They opted for hiding and taking medication in privacy which led to missed doses. The heightened fear of being seen collecting ART medication affected keeping appointments for clinic visits. Fear of stigma also influenced the choice of action when there was a clash between school activities, dosing times, and scheduled clinic appointments for ART refill. The home environment was the main facilitator for adherence. Support was the strongest motivator for adolescents to adhere and keep up with clinic visits. On a personal level, the desire to be healthy and live long was a major motivator to adhere. Conclusions. The fear of stigma shaped the adolescents’ adherence behaviour. Perceived stigma affected the time and place to take medication, the visit to the clinic for ART refill, and self-disclosure of HIV status. There is need to encourage adolescents to self-disclose their HIV status to friends since the fear of unintended disclosure fuelled perceived stigma. Planning of clinic appointments should also be consistent with realistic daily activities of adolescents.
45
Paton, John B., David E. Fisher, Stephen A. Myers, Kwang-Sun Lee, Atef Moawad, and Gail Wilson. "574 PERSISTENCE OF HIGH PERINATAL MORTALITY (PM) IN AN URBAN PERINATAL CENTER." Pediatric Research 19, no. 4 (April 1985): 206A. http://dx.doi.org/10.1203/00006450-198504000-00604.
Full text
46
Zahorodnya, O. S., V. V. Bila, Y. O. Yarotska, O. I. Klyushanova, and O. V. Akimova. "Kyiv Perinatal Center: Let pregnancy become motherhood." HEALTH OF WOMAN, no. 5-6(151-152) (July 30, 2020): 48–53. http://dx.doi.org/10.15574/hw.2020.151-152.48.
Full textAbstract:
The article presents the experience of the project on physical and psychological recovery of families after reproductive losses. The concept of fetal loss syndrome was chosen as a principle of the project, which provides both common pathogenetic mechanisms of early and late miscarriage, spontaneous and induced premature birth, which lead to neonatal death, and similar mechanisms of psychological experience of reproductive loss due to the lack of formed connection between parents and child. The main etiological factors of miscarriage, the principles of their diagnosis and the applied algorithm of treatment are considered. In particular, a detailed description of the role of progesterone deficiency in the mechanisms of miscarriage and severe obstetric complications is given, the debatability of the effectiveness of unjustified prescribing of exogenous progesterone, both from a molecular and epidemiological point of view. Attention is paid to thrombophilias of various origins, which is currently one of the recognized factors of miscarriage. The results of the project are presented, which include more than 20 meetings held in 3 years, as a result of which 20 couples were planned to have the next pregnancy and its observation. All 20 cases were completed in the Perinatal Center by timely delivery with the birth of a living healthy child, so all pregnancies became maternity. Keywords: Kyiv Perinatal Center, miscarriage, reproductive losses, pregnancy, thrombophilia, progesterone deficiency, psychology.
47
Johnson, James A. "David Gagnon, President, National Perinatal Information Center." Journal of Healthcare Management 43, no. 5 (September 1998): 385–88. http://dx.doi.org/10.1097/00115514-199809000-00002.
Full text
48
Dahlberg, Nancy L. Friest. "A Perinatal Center Based Antepartum Homecare Program." Journal of Obstetric, Gynecologic & Neonatal Nursing 17, no. 1 (January 1988): 30–34. http://dx.doi.org/10.1111/j.1552-6909.1988.tb00411.x.
Full text
49
Shpatusco, N., M. Shatalova, and I. Mogilevkina. "Cesarean section indications in the perinatal center." International Journal of Gynecology & Obstetrics 70 (2000): C84. http://dx.doi.org/10.1016/s0020-7292(00)80589-5.
Full text
50
Kim, Jin Kyu. "Plan for Establishing a Safe Perinatal Transport System." Journal of The Korean Society of Maternal and Child Health 26, no. 1 (January 31, 2022): 10–19. http://dx.doi.org/10.21896/jksmch.2022.26.1.10.
Full textAbstract:
The collapse of perinatal healthcare is inevitable considering demographic factors and factors associated with medical resources due to the rapid decrease in the fertility rate in South Korea. In order to maintain the perinatal healthcare system, an appropriate healthcare delivery system must be established, but even the regional hospitals are facing a situation in which medical care is disabled due to a shortage of workforce. Government support is required to prevent the collapse of perinatal healthcare as public healthcare, emergency healthcare, and national essential healthcare system. In reality, it is necessary to strengthen perinatal healthcare through regionalization and to establish a maternal and child transport system. However, there are no guidelines for the perinatal transport system in South Korea, which also lacks professionalism, with a focus on the simple transportation of patients. Therefore, by integrating the transport systems of advanced countries and domestic efforts to improve transport systems, a realistic perinatal transport system establishment plan is proposed as follows. In order to strengthen the perinatal healthcare center under legal and institutional support, a professional workforce equivalent to that of the emergency healthcare center is ensured to organize a specialized perinatal transport team, and a perinatal emergency information center is established to form a safe transport linkage system. The perinatal emergency information center, which provides information on perinatal healthcare, linking and evaluating transportation between hospitals, should be incorporated into the emergency healthcare system, playing a pivotal role in the perinatal emergency healthcare management system. In addition, a dedicated transport team for perinatal healthcare should be formed for each region, transport guidelines for transport vehicles and equipment should be established, and legal and financial support should be provided to ensure safe perinatal healthcare transport. The prehospitalization level perinatal transport is configured as an integrated model of the 119 paramedics, aiming at quick transport. A team of perinatal special paramedics should be organized for each base to transport patients by special vehicles, and information from the perinatal emergency information center should be used to select a transfer hospital and to receive medical guidance from a perinatal care physician during transport between hospitals. Transport between hospitals aims at safe transport with triangular transport. A perinatal transport team is in charge of transport between hospitals, and a specialist is on board in a special ambulance to provide medical care during transport between hospitals. Support from the government and local governments is absolutely necessary to strengthen the perinatal healthcare center and establish a perinatal transfer system, which must be realized through a pilot project with fee support.