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Journal articles on the topic 'Center-Gated Disk'

Author: Grafiati

Published: 4 June 2021

Last updated: 14 February 2022

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1

Altan, M. Cengiz, and Bharath N. Rao. "Closed‐form solution for the orientation field in a center‐gated disk." Journal of Rheology 39, no. 3 (May 1995): 581–99. http://dx.doi.org/10.1122/1.550714.

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2

Mazahir, S. M., G. M. Vélez-García, P. Wapperom, and D. Baird. "Fiber orientation in the frontal region of a center-gated disk: Experiments and simulation." Journal of Non-Newtonian Fluid Mechanics 216 (February 2015): 31–44. http://dx.doi.org/10.1016/j.jnnfm.2014.12.008.

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3

Park, Jang Min, and Tai Hun Kwon. "Nonisothermal transient filling simulation of fiber suspended viscoelastic liquid in a center-gated disk." Polymer Composites 32, no. 3 (December 29, 2010): 427–37. http://dx.doi.org/10.1002/pc.21061.

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4

Vélez-García, Gregorio M., Peter Wapperom, Donald G. Baird, Alex O. Aning, and Vlastimil Kunc. "Unambiguous orientation in short fiber composites over small sampling area in a center-gated disk." Composites Part A: Applied Science and Manufacturing 43, no. 1 (January 2012): 104–13. http://dx.doi.org/10.1016/j.compositesa.2011.09.024.

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5

Mazahir, S. M., G. M. Vélez-García, P. Wapperom, and D. Baird. "Evolution of fibre orientation in radial direction in a center-gated disk: Experiments and simulation." Composites Part A: Applied Science and Manufacturing 51 (August 2013): 108–17. http://dx.doi.org/10.1016/j.compositesa.2013.04.008.

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6

Kim, I. H., S. J. Park, S. T. Chung, and T. H. Kwon. "Numerical modeling of injection/compression molding for center-gated disk: Part II. Effect of compression stage." Polymer Engineering & Science 39, no. 10 (October 1999): 1943–51. http://dx.doi.org/10.1002/pen.11587.

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7

Kim, I. H., S. J. Park, S. T. Chung, and T. H. Kwon. "Numerical modeling of injection/compression molding for center-gated disk: Part I. Injection molding with viscoelastic compressible fluid model." Polymer Engineering & Science 39, no. 10 (October 1999): 1930–42. http://dx.doi.org/10.1002/pen.11586.

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8

Li, Tianyi, and Jean-François Luyé. "Optimization of Fiber Orientation Model Parameters in the Presence of Flow-Fiber Coupling." Journal of Composites Science 2, no. 4 (December 18, 2018): 73. http://dx.doi.org/10.3390/jcs2040073.

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In this paper, we propose a novel systematic procedure to minimize the discrepancy between the numerically predicted and the experimentally measured fiber orientation results on an injection-molded part. Fiber orientation model parameters are optimized simultaneously using Latin hypercube sampling and kriging-based adaptive surrogate modeling techniques. Via an adequate discrepancy measure, the optimized solution possesses correct skin–shell–core structure and global orientation evolution throughout the considered center-gated disk. Some non-trivial interaction between these parameters and flow-fiber coupling effects as well as their quantitative importance are illustrated. The parametric fine-tuning of orientation models mostly leads to a better agreement in the skin and shell regions, while the coupling effect via a fiber-dependent viscosity improves prediction in the core.

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9

Lee, Young Bok, Tai Hun Kwon, and Kyunghwan Yoon. "Numerical prediction of residual stresses and birefringence in injection/compression molded center-gated disk. Part II: Effects of processing conditions." Polymer Engineering & Science 42, no. 11 (November 2002): 2273–92. http://dx.doi.org/10.1002/pen.11115.

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10

Wapperom, Peter, and Donald G. Baird. "The use of flow type dependent strain reduction factor to improve fiber orientation predictions for an injection molded center-gated disk." Physics of Fluids 31, no. 12 (December 1, 2019): 123105. http://dx.doi.org/10.1063/1.5129679.

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11

Lee, Young Bok, Tai Hun Kwon, and Kyunghwan Yoon. "Numerical prediction of residual stresses and birefringence in injection/compression molded center-gated disk. Part I: Basic modeling and results for injection molding." Polymer Engineering & Science 42, no. 11 (November 2002): 2246–72. http://dx.doi.org/10.1002/pen.11114.

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12

Goyal, S. K., E. Chu, and M. R. Kamal. "Non-isothermal radial filling of center-gated disc cavities with viscoelastic polymer melts." Journal of Non-Newtonian Fluid Mechanics 28, no. 3 (January 1988): 373–406. http://dx.doi.org/10.1016/0377-0257(88)87007-1.

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13

Meyer, Kevin J., John T. Hofmann, and Donald G. Baird. "Initial conditions for simulating glass fiber orientation in the filling of center-gated disks." Composites Part A: Applied Science and Manufacturing 49 (June 2013): 192–202. http://dx.doi.org/10.1016/j.compositesa.2013.03.004.

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14

Lee, Y. B., and T. H. Kwon. "Modeling and numerical simulation of residual stresses and birefringence in injection molded center-gated disks." Journal of Materials Processing Technology 111, no. 1-3 (April 2001): 214–18. http://dx.doi.org/10.1016/s0924-0136(01)00524-6.

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15

Vincent, M., and J. F. Agassant. "Experimental study and calculations of short glass fiber orientation in a center gated molded disc." Polymer Composites 7, no. 2 (April 1986): 76–83. http://dx.doi.org/10.1002/pc.750070203.

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16

Li, Chien-Te, and F. C. Lai. "Visualization of the surface tension and gravitational effects on flow injection in center-gated disks." International Communications in Heat and Mass Transfer 37, no. 3 (March 2010): 230–33. http://dx.doi.org/10.1016/j.icheatmasstransfer.2009.11.009.

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17

Li, C. T., B. Y. Wu, and T. S. Chen. "Modeling study of the surface tension and gravitational effects on flow injection in center-gated disks." International Journal of Advanced Manufacturing Technology 28, no. 11-12 (June 22, 2005): 1104–10. http://dx.doi.org/10.1007/s00170-004-2479-7.

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18

Li, C. T. "Numerical and experimental study on the gravitation and surface tension effects on flow injection in center-gated disks." Journal of Materials Processing Technology 140, no. 1-3 (September 2003): 167–72. http://dx.doi.org/10.1016/s0924-0136(03)00708-8.

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19

Yu, Xinjian, Pan Li, Heyuan Feng, Jian Kang, Xichang Zheng, Yunmei Zhang, Wenhong Yang, Tong Wu, and Shuangyou Liu. "The Quick Antigen Identification By Tissue Flow Cytometry for CAR-T Therapy in Relapsed/Refractory B-Cell Malignancies without Bone Marrow Involvement or Serous Cavity Effusions." Blood 136, Supplement 1 (November 5, 2020): 11–12. http://dx.doi.org/10.1182/blood-2020-139437.

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Abstract:

In recent years, chimeric antigen receptor (CAR) T-cell therapy has been widely used to treat relapsed/refractory B-cell malignancies. Before CAR-T, the identification of target antigens on tumor cells is needed for choosing a suitable antigen-specific CAR, which is usually performed by multiparameter flow cytometry (FCM) for bone marrow (BM) samples or immunohistochemical (IHC) staining for tissue samples. However, some patients with tumor masses only and without BM involvement or serous cavity effusions (SCE) may not have much time to wait the results from IHC staining owing to rapidly growing tumor cells, therefore, we established a quick antigen identification by FCM using tissue samples. Fresh tumor tissues taken by fine or coarse needle puncture from different body parts were put in saline with 2% fetal calf serum and sent to the FCM lab as quickly as possible, once in lab, samples were processed immediately. Tissue strips were placed into a 60 mm petri dish, gently pressed by a syringe piston and repeatedly flushed with saline to separate cells from tissues; then the liquid with cells in petri dish were transferred into a 100μm cell strainer on top of 50 mL conical tube to exclude non-cellular tissue components, the strainer was washed with saline for 2-3 times. The strained cell suspension in conical tube was centrifuged at 1000rpm for 5 minutes, the supernatant was discarded by pipetting, cells were counted and resuspended with saline at a concentration of 104-105/ml, then the single cell suspension was ready for flow cytometry assay. 7-AAD and antibodies CD19/CD22/CD7/CD45 were added into the first tube to quantify viable cells and identify cells available for analysis, if dead cells were more than 30% of all cells, 7-AAD was needed for all next tubes, otherwise, it could be omitted. The standard antibody panels consist of CD10/CD20/CD34/CD19/CD38/CD45 for precursor B-cells and kappa/lambda/CD10/CD19/CD20/CD38/CD45 for mature B-cells, extra antibodies could be added according to patient's situations. Samples were performed on the 8-color BD FACSCanto II flow cytometer, and analyzed by BD FACS Diva software or Kaluza software from Beckman Coulter. Antigen expression, partial expression and no expression were defined as >80%, 20-80% and <20% of gated cells displaying interested antigen, respectively. Dim expression was defined as more than one log weaker than the normal counterpart's mean fluorescence intensity (MFI). From October 2017 through June 2020, a total of 63 patients with relapsed/refractory B-cell malignancies who had tumor masses only and no BM involvement or malignant SCE were hospitalized in our center for CAR-T treatment after failure of multiple-line therapies, including 11 (17.5%) acute lymphoblastic leukemia (ALL) and 52 (82.5%) non-Hodgkin's lymphoma (NHL), the median age was 41 years (range, 1-71) with both adults (n=47, 74.6%) and children younger than 18 years (n=16, 25.4%). Acquired events from tissue samples varied from 1000 to more than 100, 000 each tube (5 cases <5000 and 17 cases >100,000), the percentages of tumor cells in all cells available for analysis varied from 0.03% to 99.44% (5 cases <5% and 13 cases >90%). We have CD19-, CD20- and CD22-specific CAR-T cells for B-ALL and B-NHL, the choice of a CAR-T product depends on the antigen expression on tumor cells, patients with partial or no or dim expression (PND expression) of certain antigen are not suitable for the relevant antigen-specific CAR-T therapy. Among this cohort of patients, CD19 expressed in all but 1 ALL case who had accepted CD19 CAR-T; PND expression of CD20 occurred in 19.2% (10/52) of NHL patients since they were repeatedly administrated anti-CD20 antibodies in previous treatments which resulted in antigen diminishment or loss, all B-ALL patients had no or partial CD20 expression; PND expression of CD22 was seen in 18.2% (2/11) of ALL and 13.5% (7/52) of NHL. All flow results came back within hours (< 4-6 hours), much quicker than results from IHC staining which takes days. In conclusion, the correct selection of a target antigen is the basis of effective CAR-T treatment in relapsed/refractory B-cell malignancies especially for patients having accepted antibody or CAR-T therapies, our antigen detection by tissue flow cytometry provided a quick and accurate antigen identification for patients with no BM or SCE samples. Disclosures No relevant conflicts of interest to declare.

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20

Hamidi, Youssef K., Sudha Dharmavaram, Levent Aktas, and M. Cengiz Altan. "Effect of Fiber Content on Void Morphology in Resin Transfer Molded E-Glass/Epoxy Composites." Journal of Engineering Materials and Technology 131, no. 2 (March 9, 2009). http://dx.doi.org/10.1115/1.3030944.

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Effect of fiber volume fraction on occurrence, morphology, and spatial distribution of microvoids in resin transfer molded E-glass/epoxy composites is investigated. Three disk-shaped center-gated composite parts containing 8, 12, and 16 layers of randomly-oriented, E-glass fiber perform are molded, yielding 13.5%, 20.5%, and 27.5% fiber volume fractions. Voids are evaluated by microscopic image analysis of the samples obtained along the radius of these disk-shaped composites. The number of voids is found to decrease moderately with increasing fiber content. Void areal density decreased from 10.5 voids/mm2 to 9.5 voids/mm2 as fiber content is increased from 13.5% to 27.5%. Similarly, void volume fraction decreased from 3.1% to 2.5%. Increasing fiber volume fraction from 13.5% to 27.5% is found to lower the contribution of irregularly-shaped voids from 40% of total voids down to 22.4%. Along the radial direction, combined effects of void formation by mechanical entrapment and void mobility are shown to yield a spatially complex void distribution. However, increasing fiber content is observed to affect the void formation mechanisms as more voids are able to move toward the exit vents during molding. These findings are believed to be applicable not only to resin transfer molding but generally to liquid composite molding processes.

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21

"Numerical Analysis of Residual Stresses and Birefringence in Injection/Compression Molded Center-gated Disks (II) - Effects of Processing Conditions -." Transactions of the Korean Society of Mechanical Engineers A 26, no. 11 (November 1, 2002): 2355–63. http://dx.doi.org/10.3795/ksme-a.2002.26.11.2355.

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22

"Numerical Analysis of ]Residual Stresses and Birefringence in Injection/Compression Molded Center-gated Disks (I) - Modeling and Basic Results -." Transactions of the Korean Society of Mechanical Engineers A 26, no. 11 (November 1, 2002): 2342–54. http://dx.doi.org/10.3795/ksme-a.2002.26.11.2342.

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