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Journal articles on the topic 'Central Dogma of the Molecular Biology'

Author: Grafiati

Published: 4 June 2021

Last updated: 6 February 2022

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1

Morange, Michel. "The Central Dogma of molecular biology." Resonance 14, no. 3 (2009): 236–47. http://dx.doi.org/10.1007/s12045-009-0024-6.

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2

Song, Yiyun. "Central dogma, redefined." Nature Chemical Biology 17, no. 8 (2021): 839. http://dx.doi.org/10.1038/s41589-021-00850-2.

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3

Hunter, Nora. "Prion diseases and the central dogma of molecular biology." Trends in Microbiology 7, no. 7 (1999): 265–66. http://dx.doi.org/10.1016/s0966-842x(99)01543-7.

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4

Peedicayil, Jacob. "DNA methylation and the central dogma of molecular biology." Medical Hypotheses 64, no. 6 (2005): 1243–44. http://dx.doi.org/10.1016/j.mehy.2004.12.022.

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5

Schmeets, Marcel G. J. "About epigenetics and the central dogma of molecular biology." Neuropsychoanalysis 16, no. 1 (2014): 45–48. http://dx.doi.org/10.1080/15294145.2014.900936.

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6

DeBruyn, Jennifer M. "Teaching the Central Dogma of Molecular Biology using Jewelry †." Journal of Microbiology & Biology Education 13, no. 1 (2012): 62–64. http://dx.doi.org/10.1128/jmbe.v13i1.356.

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7

Schneider-Poetsch, Tilman, and Minoru Yoshida. "Along the Central Dogma—Controlling Gene Expression with Small Molecules." Annual Review of Biochemistry 87, no. 1 (2018): 391–420. http://dx.doi.org/10.1146/annurev-biochem-060614-033923.

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The central dogma of molecular biology, that DNA is transcribed into RNA and RNA translated into protein, was coined in the early days of modern biology. Back in the 1950s and 1960s, bacterial genetics first opened the way toward understanding life as the genetically encoded interaction of macromolecules. As molecular biology progressed and our knowledge of gene control deepened, it became increasingly clear that expression relied on many more levels of regulation. In the process of dissecting mechanisms of gene expression, specific small-molecule inhibitors played an important role and became

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8

Newman, Dina L., Christopher W. Snyder, J. Nick Fisk, and L. Kate Wright. "Development of the Central Dogma Concept Inventory (CDCI) Assessment Tool." CBE—Life Sciences Education 15, no. 2 (2016): ar9. http://dx.doi.org/10.1187/cbe.15-06-0124.

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Scientific teaching requires scientifically constructed, field-tested instruments to accurately evaluate student thinking and gauge teacher effectiveness. We have developed a 23-question, multiple select–format assessment of student understanding of the essential concepts of the central dogma of molecular biology that is appropriate for all levels of undergraduate biology. Questions for the Central Dogma Concept Inventory (CDCI) tool were developed and iteratively revised based on student language and review by experts. The ability of the CDCI to discriminate between levels of understanding of

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9

Liu, Chang C., Michael C. Jewett, Jason W. Chin, and Chris A. Voigt. "Toward an orthogonal central dogma." Nature Chemical Biology 14, no. 2 (2018): 103–6. http://dx.doi.org/10.1038/nchembio.2554.

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10

Tabotabo-Picardal, Marchee, and Jennifer D. Paño. "Facilitating Instruction of Central Dogma of Molecular Biology through Contextualization." Journal of Teacher Education and Research 13, no. 2 (2018): 118. http://dx.doi.org/10.5958/2454-1664.2018.00012.5.

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11

Noble, Denis. "The Illusions of the Modern Synthesis." Biosemiotics 14, no. 1 (2021): 5–24. http://dx.doi.org/10.1007/s12304-021-09405-3.

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AbstractThe Modern Synthesis has dominated biology for 80 years. It was formulated in 1942, a decade before the major achievements of molecular biology, including the Double Helix and the Central Dogma. When first formulated in the 1950s these discoveries and concepts seemed initially to completely justify the central genetic assumptions of the Modern Synthesis. The Double Helix provided the basis for highly accurate DNA replication, while the Central Dogma was viewed as supporting the Weismann Barrier, so excluding the inheritance of acquired characteristics. This article examines the languag

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12

Wright, L. Kate, J. Nick Fisk, and Dina L. Newman. "DNA → RNA: What Do Students Think the Arrow Means?" CBE—Life Sciences Education 13, no. 2 (2014): 338–48. http://dx.doi.org/10.1187/cbe.cbe-13-09-0188.

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The central dogma of molecular biology, a model that has remained intact for decades, describes the transfer of genetic information from DNA to protein though an RNA intermediate. While recent work has illustrated many exceptions to the central dogma, it is still a common model used to describe and study the relationship between genes and protein products. We investigated understanding of central dogma concepts and found that students are not primed to think about information when presented with the canonical figure of the central dogma. We also uncovered conceptual errors in student interpret

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13

Ansari, Aseem Z. "Chemical crosshairs on the central dogma." Nature Chemical Biology 3, no. 1 (2007): 2–7. http://dx.doi.org/10.1038/nchembio0107-2.

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14

Hegde, Mahabaleshwar V., and Arundhati A. Saraph. "Unstable genes unstable mind: Beyond the central dogma of molecular biology." Medical Hypotheses 77, no. 2 (2011): 165–70. http://dx.doi.org/10.1016/j.mehy.2011.03.051.

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15

Thieffry, Denis, and Sahotra Sarkar. "Forty years under the central dogma." Trends in Biochemical Sciences 23, no. 8 (1998): 312–16. http://dx.doi.org/10.1016/s0968-0004(98)01244-4.

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16

Takeuchi, Nobuto, and Kunihiko Kaneko. "The origin of the central dogma through conflicting multilevel selection." Proceedings of the Royal Society B: Biological Sciences 286, no. 1912 (2019): 20191359. http://dx.doi.org/10.1098/rspb.2019.1359.

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The central dogma of molecular biology rests on two kinds of asymmetry between genomes and enzymes: informatic asymmetry, where information flows from genomes to enzymes but not from enzymes to genomes; and catalytic asymmetry, where enzymes provide chemical catalysis but genomes do not. How did these asymmetries originate? Here, we show that these asymmetries can spontaneously arise from conflict between selection at the molecular level and selection at the cellular level. We developed a model consisting of a population of protocells, each containing a population of replicating catalytic mole

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17

Keyes, Martha E. "The Prion Challenge to the `Central Dogma' of Molecular Biology, 1965–1991." Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences 30, no. 1 (1999): 1–19. http://dx.doi.org/10.1016/s1369-8486(98)00028-4.

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18

Keyes, Martha E. "The Prion Challenge to the `Central Dogma' of Molecular Biology, 1965–1991." Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences 30, no. 2 (1999): 181–218. http://dx.doi.org/10.1016/s1369-8486(98)00029-6.

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19

Šustar, Predrag. "Crick's notion of genetic information and the ‘central dogma’ of molecular biology." British Journal for the Philosophy of Science 58, no. 1 (2007): 13–24. http://dx.doi.org/10.1093/bjps/axl018.

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20

Camacho, M. Polo. "Beyond descriptive accuracy: The central dogma of molecular biology in scientific practice." Studies in History and Philosophy of Science Part A 86 (April 2021): 20–26. http://dx.doi.org/10.1016/j.shpsa.2021.01.002.

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21

White, Harold B. "Commentary: Challenging the central dogma of teaching." Biochemistry and Molecular Biology Education 41, no. 6 (2013): 443–44. http://dx.doi.org/10.1002/bmb.20735.

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22

Chen, Xing, Chun-Chun Wang, and Na-Na Guan. "Computational Models in Non-Coding RNA and Human Disease." International Journal of Molecular Sciences 21, no. 5 (2020): 1557. http://dx.doi.org/10.3390/ijms21051557.

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23

Freitas, Xaiane Martins Silva, Hiléia Monteiro Maciel-Cabral, and Cirlande Cabral da Silva. "O ensino do dogma central da biologia molecular: dificuldades e desafios." EDUCA - Revista Multidisciplinar em Educação 7, no. 17 (2020): 452. http://dx.doi.org/10.26568/2359-2087.2020.4142.

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A questão do ensino e aprendizagem do Dogma Central da Biologia Molecular é extremamente complexa, pois exige do aluno um aporte teórico e um grau de abstração que vai além daquele que o mesmo está acostumado. A pesquisa objetivou analisar que metodologias alternativas colaboram efetivamente para o ensino e aprendizagem do Dogma Central para os alunos do Ensino Médio. A pesquisa foi realizada no Instituto Federal do Amazonas, em duas turmas do 2º ano do ensino médio, que foram divididas em dois grupos, sendo uma turma para a aplicação dos modelos alternativos e a outra, não. Em relação à utili

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24

Pérez-Ortín, José E., Vicente Tordera, and Sebastián Chávez. "Homeostasis in the Central Dogma of molecular biology: the importance of mRNA instability." RNA Biology 16, no. 12 (2019): 1659–66. http://dx.doi.org/10.1080/15476286.2019.1655352.

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25

Hussain, U. Noorul, T. Chithralekha, A. Naveen Raj, G.Sathish, A. Dharani A.Dharani, and G. Sathish G.Sathish. "A Hybrid DNA Algorithm for DES using Central Dogma of Molecular Biology (CDMB)." International Journal of Computer Applications 42, no. 20 (2012): 1–4. http://dx.doi.org/10.5120/5813-8115.

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26

Rui Gao, Juanyi Yu, Mingjun Zhang, Tzyh-Jong Tarn, and Jr-Shin Li. "Systems Theoretic Analysis of the Central Dogma of Molecular Biology: Some Recent Results." IEEE Transactions on NanoBioscience 9, no. 1 (2010): 59–70. http://dx.doi.org/10.1109/tnb.2010.2041065.

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27

Borges dos Anjos, Laura Raniere, Leandro Do Prado Assunção, Bruno Lima Freitas, et al. "Popularização da Ciência: Desmistificando o Dogma Central da Biologia Molecular." Revista de Ensino de Bioquímica 16, no. 2 (2019): 71–86. http://dx.doi.org/10.16923/reb.v16i2.761.

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Esse projeto de extensão foi apresentado durante a XII Edição do Movimento Científico e Cultural de Aparecida de Goiânia, Goiás, Brasil (MOCCA). O objetivo foi promover o conhecimento científico básico sobre o fluxo da informação genética a partir da experimentação por métodos ilustrativos. Cada participante respondeu um questionário para avaliar seu conhecimento prévio sobre o tema. Em seguida, foi direcionado a um monitor que o acompanhava, no ambiente interativo, apresentando ilustrações com maquetes, painéis, modelos tridimensionais, bem como, na realização da extração simples de DNA de um

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28

Schreiber, Stuart L. "Small molecules: the missing link in the central dogma." Nature Chemical Biology 1, no. 2 (2005): 64–66. http://dx.doi.org/10.1038/nchembio0705-64.

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29

Pisignano, Giuseppina, and Michael Ladomery. "Post-Transcriptional Regulation through Long Non-Coding RNAs (lncRNAs)." Non-Coding RNA 7, no. 2 (2021): 29. http://dx.doi.org/10.3390/ncrna7020029.

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The discovery of thousands of non-coding RNAs (ncRNAs) pervasively transcribed from the eukaryotic genome has revolutionized the “central dogma” of biology and shifted the attention on the role of RNAs as regulatory molecules, more than simply traditional mediators of genomic information [...]

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30

Young, Eric, and Hal Alper. "Synthetic Biology: Tools to Design, Build, and Optimize Cellular Processes." Journal of Biomedicine and Biotechnology 2010 (2010): 1–12. http://dx.doi.org/10.1155/2010/130781.

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The general central dogma frames the emergent properties of life, which make biology both necessary and difficult to engineer. In a process engineering paradigm, each biological process stream and process unit is heavily influenced by regulatory interactions and interactions with the surrounding environment. Synthetic biology is developing the tools and methods that will increase control over these interactions, eventually resulting in an integrative synthetic biology that will allow ground-up cellular optimization. In this review, we attempt to contextualize the areas of synthetic biology int

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31

Kimsey, Isaac J., Huiqing Zhou, Heidi Alvey, and Hashim M. Al-Hashimi. "120 Role of dynamic base pair polymorphism in the central dogma of molecular biology." Journal of Biomolecular Structure and Dynamics 33, sup1 (2015): 75–76. http://dx.doi.org/10.1080/07391102.2015.1032753.

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32

Love‡, Martha W. "The central dogma: From Danielle steel to Steely Dan." Biochemistry and Molecular Biology Education 39, no. 2 (2011): 180. http://dx.doi.org/10.1002/bmb.20485.

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33

de Lorenzo, Víctor. "From theselfish genetoselfish metabolism: Revisiting the central dogma." BioEssays 36, no. 3 (2014): 226–35. http://dx.doi.org/10.1002/bies.201300153.

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34

Holliday, R. "The early years of molecular biology: personal recollections." Notes and Records of the Royal Society of London 57, no. 2 (2003): 195–208. http://dx.doi.org/10.1098/rsnr.2003.0206.

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The early years of molecular biology were characterized by a strong interaction between theory and experiment. This included the elucidation of the structure of DNA itself; genetic fine structure, recombination and repair; DNA replication; template–directed protein synthesis; the universality of the triplet genetic code, and the co–linearity of the DNA sequence of structural genes and the sequence of amino acids in proteins. The principle of co–linearity was later modified when split genes were discovered.. It is suggested that accurate splicing of gene transcripts might also be template direc

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35

Robinson, Douglas N., and Pablo A. Iglesias. "Bringing the physical sciences into your cell biology research." Molecular Biology of the Cell 23, no. 21 (2012): 4167–70. http://dx.doi.org/10.1091/mbc.e12-05-0354.

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Historically, much of biology was studied by physicists and mathematicians. With the advent of modern molecular biology, a wave of researchers became trained in a new scientific discipline filled with the language of genes, mutants, and the central dogma. These new molecular approaches have provided volumes of information on biomolecules and molecular pathways from the cellular to the organismal level. The challenge now is to determine how this seemingly endless list of components works together to promote the healthy function of complex living systems. This effort requires an interdisciplinar

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36

Sikumbang, D., I. Rakhmawati, and T. Suwandi. "Investigating the Cognitive Structure of Biology Preservice Teacher about Central Dogma of Molecular Biology Through Word Association Test." Journal of Physics: Conference Series 1155 (February 2019): 012047. http://dx.doi.org/10.1088/1742-6596/1155/1/012047.

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37

Marks, John. "Molecular Biology in the Work of Deleuze and Guattari." Paragraph 29, no. 2 (2006): 81–97. http://dx.doi.org/10.3366/prg.2006.0016.

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This article looks at Deleuze and Guattari's understanding of molecular biology, focusing particularly on their reading of two highly influential works by the eminent French molecular biologists François Jacob and Jacques Monod, La logique du vivant (The Logic of Living Systems) and Le hasard et la nécessité (Chance and Necessity). In these two works, Jacob and Monod present the significance of molecular biology in broadly reductionist terms. What is more, the lac operon model of gene regulation that they propose serves to reinforce the so-called Central Dogma of molecular biology, according t

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38

Bustamante, Carlos, Wei Cheng, and Yara X. Mejia. "Revisiting the Central Dogma One Molecule at a Time." Cell 145, no. 1 (2011): 160. http://dx.doi.org/10.1016/j.cell.2011.02.043.

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39

Werner, Eric. "Genome semantics, in silico multicellular systems and the Central Dogma." FEBS Letters 579, no. 8 (2005): 1779–82. http://dx.doi.org/10.1016/j.febslet.2005.02.011.

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40

Reinagel, Adam, and Elena Bray Speth. "Beyond the Central Dogma: Model-Based Learning of How Genes Determine Phenotypes." CBE—Life Sciences Education 15, no. 1 (2016): ar4. http://dx.doi.org/10.1187/cbe.15-04-0105.

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In an introductory biology course, we implemented a learner-centered, model-based pedagogy that frequently engaged students in building conceptual models to explain how genes determine phenotypes. Model-building tasks were incorporated within case studies and aimed at eliciting students’ understanding of 1) the origin of variation in a population and 2) how genes/alleles determine phenotypes. Guided by theory on hierarchical development of systems-thinking skills, we scaffolded instruction and assessment so that students would first focus on articulating isolated relationships between pairs of

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41

Takemura, Masaharu, and Mario Kurabayashi. "Using analogy role-play activity in an undergraduate biology classroom to show central dogma revision." Biochemistry and Molecular Biology Education 42, no. 4 (2014): 351–56. http://dx.doi.org/10.1002/bmb.20803.

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42

Rajagopal, Indira, and Kevin Ahern. "Song: Central dogma zen (to the tune of “Those Were the Days”)." Biochemistry and Molecular Biology Education 37, no. 1 (2009): 68. http://dx.doi.org/10.1002/bmb.20213.

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43

Jafari, Mohieddin, Naser Ansari-Pour, Sadegh Azimzadeh, and Mehdi Mirzaie. "A logic-based dynamic modeling approach to explicate the evolution of the central dogma of molecular biology." PLOS ONE 12, no. 12 (2017): e0189922. http://dx.doi.org/10.1371/journal.pone.0189922.

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44

Holme, Thomas A. "Should Chemistry Education Be Doing More to Support the Teaching of the Central Dogma of Molecular Biology?" Journal of Chemical Education 98, no. 2 (2021): 255–56. http://dx.doi.org/10.1021/acs.jchemed.1c00054.

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45

Moss, Bernard. "Investigating Viruses During the Transformation of Molecular Biology: Part II." Annual Review of Virology 7, no. 1 (2020): 15–36. http://dx.doi.org/10.1146/annurev-virology-021020-100558.

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My scientific career started at an extraordinary time, shortly after the discoveries of the helical structure of DNA, the central dogma of DNA to RNA to protein, and the genetic code. Part I of this series emphasizes my education and early studies highlighted by the isolation and characterization of numerous vaccinia virus enzymes, determination of the cap structure of messenger RNA, and development of poxviruses as gene expression vectors for use as recombinant vaccines. Here I describe a shift in my research focus to combine molecular biology and genetics for a comprehensive understanding of

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46

Nakamura, Hideki, Robert DeRose, and Takanari Inoue. "Harnessing biomolecular condensates in living cells." Journal of Biochemistry 166, no. 1 (2019): 13–27. http://dx.doi.org/10.1093/jb/mvz028.

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Abstract As part of the ‘Central Dogma’ of molecular biology, the function of proteins and nucleic acids within a cell is determined by their primary sequence. Recent work, however, has shown that within living cells the role of many proteins and RNA molecules can be influenced by the physical state in which the molecule is found. Within living cells, both protein and RNA molecules are observed to condense into non-membrane-bound yet distinct structures such as liquid droplets, hydrogels and insoluble aggregates. These unique intracellular organizations, collectively termed biomolecular conden

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47

Dorrell, Michael I., and Jennifer E. Lineback. "Using Shapes & Codes to Teach the Central Dogma of Molecular Biology: A Hands-On Inquiry-Based Activity." American Biology Teacher 81, no. 3 (2019): 202–9. http://dx.doi.org/10.1525/abt.2019.81.3.202.

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The central dogma of molecular biology is key to understanding the relationship between genotype and phenotype, although it remains a challenging concept to teach and learn. We describe an activity sequence that engages high school students directly in modeling the major processes of protein synthesis using the major components of translation. Students use a simple system of codes to generate paper chains, allowing them to learn why codons are three nucleotides in length, the purpose of start and stop codons, the importance of the promoter region, and how to use the genetic code. Furthermore,

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48

Perovic, Slobodan. "The rebirth of the morphogenetic field as an explanatory tool in biology." Filozofija i drustvo 24, no. 4 (2013): 181–98. http://dx.doi.org/10.2298/fid1304181p.

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I discuss two uses of the concept of the morphogenetic field, a tool of the 19th century biology motivated by particular ontological views of the time, which has been re-emerging and increasingly relevant in explaining microbiological phenomena. I also consider the relation of these uses to the Central Dogma of modern biology as well as Modern Synthesis of Darwinism and genetics. An induced morphogenetic field is determined by a physical (e.g., gravitational) field, or it acquires a physical (e.g., visco-elastic) field?s characteristics. Such a morphogenetic field presents only a weak challeng

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49

Hartenian, Ella, and Britt A. Glaunsinger. "Feedback to the central dogma: cytoplasmic mRNA decay and transcription are interdependent processes." Critical Reviews in Biochemistry and Molecular Biology 54, no. 4 (2019): 385–98. http://dx.doi.org/10.1080/10409238.2019.1679083.

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50

Emanuele, Enzo. "Challenging the Central Dogma of Skin Photobiology: Are Proteins More Important than DNA?" Journal of Investigative Dermatology 134, no. 7 (2014): 2052–53. http://dx.doi.org/10.1038/jid.2014.64.

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