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Journal articles on the topic 'Central Fab'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Mohamed, Muhammad Azfar, Mazshurraiezal Nasir, Mohd Syukri Said, et al. "FACIES ANALYSIS AND DEPOSITIONAL MODEL OF THE MIDDLE-UPPER TRIASSIC SEMANTAN FORMATION, CENTRAL PAHANG, MALAYSIA." ASEAN Engineering Journal 12, no. 2 (2022): 195–203. http://dx.doi.org/10.11113/aej.v12.17312.

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This study details the sedimentological analysis of the Middle-Upper Triassic Semantan Formation in the Jerantut-Temerloh-Kemayan region of central Pahang. Seven (F1-7) facies have been identified which are; F1) poorly sorted conglomerate, F2) pebbly sandstone, F3) structureless-to-parallel laminated sandstone, F4) wavy-to-ripple fine-to-medium laminated sandstone, F5) slumped thin-interbeded sandstone and shale , F6) interbedded sandstone and shale, and F7) shale, represent a subordinate part of the Semantan Formation. Examination of the succession of the vertical facies resulted in concessio

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de Almeida, Monique Marylin Alves, Cleide dos Santos Souza, Naiara Silva Dourado та ін. "Phytoestrogen Agathisflavone Ameliorates Neuroinflammation-Induced by LPS and IL-1β and Protects Neurons in Cocultures of Glia/Neurons". Biomolecules 10, № 4 (2020): 562. http://dx.doi.org/10.3390/biom10040562.

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Inflammation and oxidative stress are common aspects of most neurodegenerative diseases in the central nervous system. In this context, microglia and astrocytes are central to mediating the balance between neuroprotective and neurodestructive mechanisms. Flavonoids have potent anti-inflammatory and antioxidant properties. Here, we have examined the anti-inflammatory and neuroprotective potential of the flavonoid agathisflavone (FAB), which is derived from the Brazilian plant Poincianella pyramidalis, in in vitro models of neuroinflammation. Cocultures of neurons/glial cells were exposed to lip

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3

Mitropoulou, Alkistis N., Tom Ceska, James T. Heads, et al. "Engineering the Fab fragment of the anti-IgE omalizumab to prevent Fab crystallization and permit IgE-Fc complex crystallization." Acta Crystallographica Section F Structural Biology Communications 76, no. 3 (2020): 116–29. http://dx.doi.org/10.1107/s2053230x20001466.

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Immunoglobulin E (IgE) plays a central role in the allergic response, in which cross-linking of allergen by Fc∊RI-bound IgE triggers mast cell and basophil degranulation and the release of inflammatory mediators. The high-affinity interaction between IgE and Fc∊RI is a long-standing target for therapeutic intervention in allergic disease. Omalizumab is a clinically approved anti-IgE monoclonal antibody that binds to free IgE, also with high affinity, preventing its interaction with Fc∊RI. All attempts to crystallize the pre-formed complex between the omalizumab Fab and the Fc region of IgE (Ig

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Clemens, Daniel L., Bai-Yu Lee, and Marcus A. Horwitz. "The Mycobacterium tuberculosis Phagosome in Human Macrophages Is Isolated from the Host Cell Cytoplasm." Infection and Immunity 70, no. 10 (2002): 5800–5807. http://dx.doi.org/10.1128/iai.70.10.5800-5807.2002.

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ABSTRACT Knowledge of whether Mycobacterium tuberculosis resides within a relatively impermeable membrane-bound vacuole or is free within the cytoplasm within its host cell is central to an understanding of the immunobiology of this intracellular parasite but is a matter of controversy. To explore this issue, we assessed the accessibility of medium-size protein molecules (Fab fragments of 50,000 Da) to M. tuberculosis within human macrophages. We infected the macrophages with wild-type or green fluorescent protein-expressing M. tuberculosis, microinjected Fab fragments directed against a major

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Redpath, Nicholas T., Yibin Xu, Nicholas J. Wilson та ін. "Production of a human neutralizing monoclonal antibody and its crystal structure in complex with ectodomain 3 of the interleukin-13 receptor α1". Biochemical Journal 451, № 2 (2013): 165–75. http://dx.doi.org/10.1042/bj20121819.

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Gene deletion studies in mice have revealed critical roles for IL (interleukin)-4 and -13 in asthma development, with the latter controlling lung airways resistance and mucus secretion. We have now developed human neutralizing monoclonal antibodies against human IL-13Rα1 (IL-13 receptor α1) subunit that prevent activation of the receptor complex by both IL-4 and IL-13. We describe the crystal structures of the Fab fragment of antibody 10G5H6 alone and in complex with D3 (ectodomain 3) of IL-13Rα1. Although the structure showed significant domain swapping within a D3 dimer, we showed that Arg23

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Crucillà, Salvatore, Federico Caldart, Marco Michelon, Giovanni Marasco, and Andrea Costantino. "Functional Abdominal Bloating and Gut Microbiota: An Update." Microorganisms 12, no. 8 (2024): 1669. http://dx.doi.org/10.3390/microorganisms12081669.

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(1) Background: Functional abdominal bloating and distension (FAB/FAD) are common disorders of the gut–brain interaction. Their physiopathology is complex and not completely clarified, although gut microbiota imbalances play a central role. The treatment of FAB/FAD still represents a clinical challenge for both patients and healthcare providers. Gut microbiota modulation strategies might play a crucial role in their management. The aim of this narrative review was to update the current evidence on FAB/FAD, with a focus on gut microbiota. (2) Methods: In October 2023, a review was conducted thr

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Kucharska, Iga, Špela Binter, Rajagopal Murugan, et al. "High-density binding to Plasmodium falciparum circumsporozoite protein repeats by inhibitory antibody elicited in mouse with human immunoglobulin repertoire." PLOS Pathogens 18, no. 11 (2022): e1010999. http://dx.doi.org/10.1371/journal.ppat.1010999.

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Antibodies targeting the human malaria parasite Plasmodium falciparum circumsporozoite protein (PfCSP) can prevent infection and disease. PfCSP contains multiple central repeating NANP motifs; some of the most potent anti-infective antibodies against malaria bind to these repeats. Multiple antibodies can bind the repeating epitopes concurrently by engaging into homotypic Fab-Fab interactions, which results in the ordering of the otherwise largely disordered central repeat into a spiral. Here, we characterize IGHV3-33/IGKV1-5-encoded monoclonal antibody (mAb) 850 elicited by immunization of tra

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Oosterbroek, Pjotr, and Ida R. M. Tangelder. "A HYBRID POPULATION OF NEPHROTOMA (DIPTERA: TIPULIDAE) FROM A CENTRAL TEXAS REFUGIUM." Canadian Entomologist 119, no. 1 (1987): 45–47. http://dx.doi.org/10.4039/ent11945-1.

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AbstractA discussion is presented about specimens that are morphologically intermediate between Nephrotoma ferruginea (Fab.) and N. suturalis suturalis (Loew). The specimens came from far outside the present ranges of these two species, namely Kerrville, Texas. It is concluded that the specimens might represent a population of hybrids. It is further estimated that the withdrawal of the parental species from central Texas could possibly have occurred a thousand years ago or earlier.

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Bzymek, Krzysztof P., Yuelong Ma, Kendra A. Avery, David A. Horne, and John C. Williams. "Cyclization strategies of meditopes: affinity and diffraction studies of meditope–Fab complexes." Acta Crystallographica Section F Structural Biology Communications 72, no. 6 (2016): 434–42. http://dx.doi.org/10.1107/s2053230x16007202.

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Recently, a unique binding site for a cyclic 12-residue peptide was discovered within a cavity formed by the light and heavy chains of the cetuximab Fab domain. In order to better understand the interactions that drive this unique complex, a number of variants including the residues within the meditope peptide and the antibody, as well as the cyclization region of the meditope peptide, were created. Here, multiple crystal structures of meditope peptides incorporating different cyclization strategies bound to the central cavity of the cetuximab Fab domain are presented. The affinity of each cyc

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Duncan, J., N. Murphy, E. Fitzpatrick, R. Nelson, and K. Hurley. "P036: Digoxin immune fab treatment for digoxin and non-digoxin cardioactive steroid toxicity: a scoping review." CJEM 21, S1 (2019): S75—S76. http://dx.doi.org/10.1017/cem.2019.227.

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Introduction: Cardioactive steroid poisoning occurs worldwide with the use of pharmaceutical digoxin and botanical cardiac glycosides. The wholesale price of the antidote, digoxin immune fab, has increased over 300% from 2010 to 2015. Our objective was to identify gaps in the existing literature with respect to the use of digoxin immune fab in cardioactive steroid toxicity in acute care settings. Methods: We used scoping study methodology, as described by Arksey and O'Malley, to assess the range and scope of empiric research and will report: 1) sources of cardioactive steroid toxicity in acute

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Huang, B. S., and F. H. Leenen. "Blockade of brain "ouabain" prevents sympathoexcitatory and pressor responses to high sodium in SHR." American Journal of Physiology-Heart and Circulatory Physiology 271, no. 1 (1996): H103—H108. http://dx.doi.org/10.1152/ajpheart.1996.271.1.h103.

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The effects of blockade of brain "ouabain" by central infusion of antibody Fab fragments, which bind ouabain and brain "ouabain" with high affinity, on sodium-sensitive hypertension were studied in spontaneously hypertensive rats (SHR) from 5 to 9 wk of age on high- or regular sodium diet. The Fab fragments or, in controls, gamma-globulins were infused intracerebroventricularly via osmotic minipump. Blood pressure (BP), heart rate (HR), and renal sympathetic nerve activity (RSNA) and their responses to air stress and to the alpha 2-adrenoceptor agonist guanabenz intracerebroventricularly were

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Sun, Tao, Jiyuan Yang, Maximilian Gamburg, et al. "IMMU-50. BBB CROSSING NANO-IMMUNOMEDICINE COMBINATION THERAPY TO TREAT BRAIN PRIMARY CENTRAL NERVOUS SYSTEM LYMPHOMA." Neuro-Oncology 22, Supplement_2 (2020): ii115. http://dx.doi.org/10.1093/neuonc/noaa215.480.

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Abstract INTRODUCTION Lack of standard treatment of Primary Central Nervous System Lymphoma (PCNSL) was acknowledged in phase III intergroup study (HOVON 105/ALLG NHL 24). PCNSL incidence is increasing for unknown reasons, particularly among persons over 65 years. One of the major limitations of successful treatment of PCNSL is the blood-brain barrier (BBB), which prevents drug delivery into the brain. METHODS Polymer nanoconjugate based on biodegradable poly(N-(2-hydroxypropyl) methacrylamide) (PHPMA) was used for treatment of BALB/C mice with intracranially inoculated murine A20 lymphoma. PH

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Haque, S., K. Saizawa, J. Rojo, and C. A. Janeway. "The influence of valence on the functional activities of monoclonal anti-L3T4 antibodies. Discrimination of signaling from other effects." Journal of Immunology 139, no. 10 (1987): 3207–12. http://dx.doi.org/10.4049/jimmunol.139.10.3207.

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Abstract Anti-L3T4 antibodies have different functional effects on different ligands that activate a cloned, L3T4+ helper T cell line. It is reported here that some of these effects involve positive or negative signaling induced by cross-linking L3T4 molecules, because such effects are not observed using the Fab fragment of anti-L3T4. However, the Fab fragment does inhibit responses to antigen:self class II major histocompatibility complex (MHC) and to anti-T cell receptor monoclonal antibodies directed at a particular V region epitope. The finding that the Fab fragment of anti-L3T4, which doe

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McManama, G., JN Lindon, M. Kloczewiak, et al. "Platelet aggregation by fibrinogen polymers crosslinked across the E domain." Blood 68, no. 2 (1986): 363–71. http://dx.doi.org/10.1182/blood.v68.2.363.363.

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Abstract There is evidence that platelet interactions with artificial surfaces are mediated by plasma proteins, especially fibrinogen, adsorbed on the surfaces. Multiple site interactions between fibrinogen molecules adsorbed in high concentration and receptors in the unactivated platelet may be sufficient for platelet adhesion and subsequent activation. To examine this hypothesis, we prepared soluble polymers of fibrinogen. Polymers produced by interaction of fibrinogen with Fab'2 fragments of antibodies against fibrinogen's E (central) domain (Fg- Fab'2(E] induced, in gel-filtered platelets,

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McManama, G., JN Lindon, M. Kloczewiak, et al. "Platelet aggregation by fibrinogen polymers crosslinked across the E domain." Blood 68, no. 2 (1986): 363–71. http://dx.doi.org/10.1182/blood.v68.2.363.bloodjournal682363.

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There is evidence that platelet interactions with artificial surfaces are mediated by plasma proteins, especially fibrinogen, adsorbed on the surfaces. Multiple site interactions between fibrinogen molecules adsorbed in high concentration and receptors in the unactivated platelet may be sufficient for platelet adhesion and subsequent activation. To examine this hypothesis, we prepared soluble polymers of fibrinogen. Polymers produced by interaction of fibrinogen with Fab'2 fragments of antibodies against fibrinogen's E (central) domain (Fg- Fab'2(E] induced, in gel-filtered platelets, aggregat

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Gu, Jiang, Yu Lei, Yuanping Huang, et al. "Fab fragment glycosylated IgG may play a central role in placental immune evasion." Human Reproduction 30, no. 2 (2014): 380–91. http://dx.doi.org/10.1093/humrep/deu323.

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Harkness, R. D., and N. G. Maroudas. "Central place foraging by an ant (Cataglyphis bicolor Fab.): a model of searching." Animal Behaviour 33, no. 3 (1985): 916–28. http://dx.doi.org/10.1016/s0003-3472(85)80026-9.

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18

Fisicaro, Francesco, Giuseppe Lanza, Mariagiovanna Cantone, et al. "Clinical and Electrophysiological Hints to TMS in De Novo Patients with Parkinson’s Disease and Progressive Supranuclear Palsy." Journal of Personalized Medicine 10, no. 4 (2020): 274. http://dx.doi.org/10.3390/jpm10040274.

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Background: Transcranial magnetic stimulation (TMS) can non-invasively probe cortical excitability in movement disorders, although clinical significance is still controversial, especially at early stages. We compare single-pulse TMS in two prototypic synucleinopathy and tauopathy—i.e., Parkinson’s disease (PD) and Progressive Supranuclear Palsy (PSP), respectively—to find neurophysiological differences and identify early measures associated with cognitive impairment. Methods: 28 PD and 23 PSP de novo patients were age-matched with 28 healthy controls, all right-handed and drug-free. Amplitude

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Zarco Juarez, Mónica, Joel Omar Martínez, Olivia Noguez Cordova, et al. "A Green Approach to the Production of Hybrid Diindolylmethane-Phenylboronic Acids via a 3MCR: Promising Antineoplasic Molecules." Journal of Chemistry 2013 (2013): 1–9. http://dx.doi.org/10.1155/2013/531208.

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The current role of the “Green Chemistry Protocol” in multicomponent reactions is first highlighted. Then, the green approach to the production of three novel hybrid diindolylmethanes-phenylboronic acids via a 3MCR is discussed, which features the following: solventless conditions, the use of microwave irradiation to activate the reactions, the absence of catalyst, and an efficient atom economy. The products were achieved with moderate yields (41–61%) within a short time frame (5 min) and appropriately characterized by elemental analysis and spectroscopic methods (NMR:1H,13C,11B; MS: EI, CI, F

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Benny, Danilo Belviso, Felice Mangiatordi Giuseppe, Alberga Domenico, Mangini Vincenzo, Carrozzini Benedetta, and Caliandro Rocco. "Structural Characterization of the Full-Length Anti-CD20 Antibody Rituximab." Front Mol Biosci 9 (February 6, 2023): 823174. https://doi.org/10.3389/fmolb.2022.823174.

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Rituximab, a murine–human chimera, is the first monoclonal antibody (mAb) developed as a therapeutic agent to target CD20 protein. Its Fab domain and its interaction with CD20 have been extensively studied and high-resolution atomic models obtained by X-ray diffraction or cryo-electron microscopy are available. However, the structure of the full-length antibody is still missing as the inherent protein flexibility hampers the formation of well-diffracting crystals and the reconstruction of 3D microscope images. The global structure of rituximab from its dilute solution is here elucidated

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AL-Baldawi, Shahad Ali Ahmed, Nabeeha Najatee Akram, and Zead I. Ibrahim. "The outcome of B-cell Non-Hodgkin's lymphoma in children treated with modified UKCCSG FAB LMB 96 protocol: A single center experience." Baghdad Journal of Biochemistry and Applied Biological Sciences 5, no. 1 (2024): 9–24. http://dx.doi.org/10.47419/bjbabs.v5i01.268.

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Introduction: Non-Hodgkin lymphoma (NHL) results from the malignant proliferation of cells of lymphocytic lineage. Aim: To asses outcome of B-cell Non-Hodgkin ’s lymphoma in children treated with modified FAB LMB 96 protocol. Patients and methods: This descriptive retrospective study for 103 patients <14 years with B-cell non-Hodgkin’s lymphoma in Child Central Teaching Hospital from 1st January 2010 to 31 December 2014. All cases were treated with Modified FAB LMB 96 protocol. According to modified UKCCSG NHL FAB 96 PROTOCOL: patients divided into low risk (group A) which include (complete

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Silva, Thays Ramos, Fábio Pinto Da Silva, and Evelise Anicet Ruthschilling. "Laboratórios de fabricação digital: uma revisão sistemática." Revista Geometria Gráfica 3, no. 1 (2019): 20. http://dx.doi.org/10.51359/2595-0797.2019.241302.

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O objetivo deste artigo é mapear quais temáticas vêm sendo abordadas emproduções científicas acerca de laboratórios de fabricação, e quais tipos demetodologias são empregadas nestes estudos, a partir de uma revisão sistemática de artigos e dissertações que tenham esse tipo de espaço como tema central. A busca se deu em bases de dados como Web of Science, SciELO, Scopus e Google Acadêmico (utilizado pela escassez de trabalhos desenvolvidos no Brasil nas outras bases de dados), incluindo trabalhos publicados entre 2014 e 2018, em português, inglês e espanhol. Foram analisados 26 artigos que cont

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Foisner, R., B. Feldman, L. Sander, and G. Wiche. "Monoclonal antibody mapping of structural and functional plectin epitopes." Journal of Cell Biology 112, no. 3 (1991): 397–405. http://dx.doi.org/10.1083/jcb.112.3.397.

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To map structural and functional epitopes of the cytomatrix protein plectin, a set of mAbs was prepared by immunization of mice. Using immunoblot analysis of plectin fragments obtained after limited digestion with various proteases, two groups of mAbs were distinguished. The epitopes of one group (1) were located on a 130-kD terminal segment of the plectin 300-kD polypeptide chain, whereas those of the other group (2) bound within a 40kD segment confined to a central domain of the polypeptide chain. Domains containing the epitopes of group 2 mAbs were shown to include in vitro phosphorylation

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Leenen, Frans H. H., Baoxue Yuan, and Bing S. Huang. "Brain “ouabain” and angiotensin II contribute to cardiac dysfunction after myocardial infarction." American Journal of Physiology-Heart and Circulatory Physiology 277, no. 5 (1999): H1786—H1792. http://dx.doi.org/10.1152/ajpheart.1999.277.5.h1786.

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In chronic heart failure (CHF), sympathetic activity increases in parallel with the impairment of left ventricle (LV) function, and sympathetic hyperactivity has been postulated to contribute to the progression of heart failure. In the brain, compounds with ouabain-like activity (“ouabain,” for brevity) and the renin-angiotensin system contribute to sympathetic hyperactivity in rats with CHF after myocardial infarction (MI). In the present studies, we assessed whether, in rats, chronic blockade of brain “ouabain” or the brain renin-angiotensin system inhibits the post-MI LV dysfunction. In rat

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Huang, Bing S., Shereeni J. Veerasingham, and Frans H. H. Leenen. "Brain “ouabain,” ANG II, and sympathoexcitation by chronic central sodium loading in rats." American Journal of Physiology-Heart and Circulatory Physiology 274, no. 4 (1998): H1269—H1276. http://dx.doi.org/10.1152/ajpheart.1998.274.4.h1269.

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Both brain ouabain-like activity (“ouabain”) and brain angiotensin II (ANG II) contribute to the sympathoexcitatory and pressor responses to high sodium intake in spontaneously hypertensive (SHR) and Dahl salt-sensitive (Dahl S) rats. To assess whether increases in cerebrospinal fluid (CSF) sodium can mimic this pattern of changes, Wistar rats were chronically infused with artificial CSF (aCSF) or sodium-rich aCSF (0.8 or 1.2 M sodium) intracerebroventricularly through osmotic minipumps for 14 days. Sodium-rich aCSF (0.8 M) was also infused intracerebroventricularly for 2 wk concomitantly with

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Whattam, Scott A., John W. Shervais, Mark K. Reagan, et al. "Mineral compositions and thermobarometry of basalts and boninites recovered during IODP Expedition 352 to the Bonin forearc." American Mineralogist 105, no. 10 (2020): 1490–507. http://dx.doi.org/10.2138/am-2020-6640.

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Abstract Central aims of IODP Expedition 352 were to delineate and characterize the magmatic stratigraphy in the Bonin forearc to define key magmatic processes associated with subduction initiation and their potential links to ophiolites. Expedition 352 penetrated 1.2 km of magmatic basement at four sites and recovered three principal lithologies: tholeiitic forearc basalt (FAB), high-Mg andesite, and boninite, with subordinate andesite. Boninites are subdivided into basaltic, low-Si, and high-Si varieties. The purpose of this study is to determine conditions of crystal growth and differentiat

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Haferlach, Torsten, Claudia Schoch, Helmut Löffler, et al. "Morphologic Dysplasia in De Novo Acute Myeloid Leukemia (AML) Is Related to Unfavorable Cytogenetics but Has No Independent Prognostic Relevance Under the Conditions of Intensive Induction Therapy: Results of a Multiparameter Analysis From the German AML Cooperative Group Studies." Journal of Clinical Oncology 21, no. 2 (2003): 256–65. http://dx.doi.org/10.1200/jco.2003.08.005.

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Purpose: On the basis of cytomorphology according to the French-American-British (FAB) classification, we evaluated the prognostic impact of dysplastic features and other parameters in de novo acute myeloid leukemia (AML). We also assessed the clinical significance of the recently introduced World Health Organization (WHO) classification for AML, which proposed dysplasia as a new parameter for classification. Patients and Methods: We analyzed prospectively 614 patients with de novo AML, all of whom were diagnosed by central morphologic analysis and treated within the German AML Cooperative Gro

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Huang, Bing S., Warren J. Cheung, Hao Wang, Junhui Tan, Roselyn A. White, and Frans H. H. Leenen. "Activation of brain renin-angiotensin-aldosterone system by central sodium in Wistar rats." American Journal of Physiology-Heart and Circulatory Physiology 291, no. 3 (2006): H1109—H1117. http://dx.doi.org/10.1152/ajpheart.00024.2006.

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Functional studies indicate that the sympathoexcitatory and pressor responses to an increase in cerebrospinal fluid (CSF) [Na+] by central infusion of Na+-rich artificial cerebrospinal fluid (aCSF) in Wistar rats are mediated in the brain by mineralocorticoid receptor (MR) activation, ouabain-like compounds (OLC), and AT1-receptor stimulation. In the present study, we examined whether increasing CSF [Na+] by intracerebroventricular infusion of Na+-rich aCSF activates MR and thereby increases OLC and components of the renin-angiotensin system in the brain. Male Wistar rats received via osmotic

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Webb, David K. H., Georgina Harrison, Richard F. Stevens, Brenda G. Gibson, Ian M. Hann, and Keith Wheatley. "Relationships between age at diagnosis, clinical features, and outcome of therapy in children treated in the Medical Research Council AML 10 and 12 trials for acute myeloid leukemia." Blood 98, no. 6 (2001): 1714–20. http://dx.doi.org/10.1182/blood.v98.6.1714.

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Abstract Between May 1988 and June 2000, 698 children were treated in the Medical Research Council acute myeloid leukemia 10 and 12 trials. The presenting features and outcomes of therapy in these children were compared by age. Although there was no single cutoff in age, younger children were more likely to have intermediate risk and less likely to have favorable cytogenetics (P &lt; .001), and they had a higher incidence of translocations involving chromosome 11q23 (P &lt; .001). The distribution of French-American-British (FAB) types also varied with age; FAB types M5 (P &lt; .00

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Benton, Donald J., Andrea Nans, Lesley J. Calder, et al. "Influenza hemagglutinin membrane anchor." Proceedings of the National Academy of Sciences 115, no. 40 (2018): 10112–17. http://dx.doi.org/10.1073/pnas.1810927115.

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Viruses with membranes fuse them with cellular membranes, to transfer their genomes into cells at the beginning of infection. For Influenza virus, the membrane glycoprotein involved in fusion is the hemagglutinin (HA), the 3D structure of which is known from X-ray crystallographic studies. The soluble ectodomain fragments used in these studies lacked the “membrane anchor” portion of the molecule. Since this region has a role in membrane fusion, we have determined its structure by analyzing the intact, full-length molecule in a detergent micelle, using cryo-EM. We have also compared the structu

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Wikstrand, C. J., P. A. Humphrey, Y. S. Lee, et al. "Specific Imaging of Human Brain Tumor Xenografts Utilizing Radiolabelled Monoclonal Antibodies (MAbs)." Nuklearmedizin 25, no. 06 (1986): 210–15. http://dx.doi.org/10.1055/s-0038-1624344.

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At the present time, specific imaging and treatment of central nervous system malignancies is not possible. The development of monoclonal hybridoma technology may provide the solution to this problem. We have utilized human glioma-derived cell lines (HGCL) transplanted subcutaneously and intracranially into athymic mice and rats to evaluate the imaging and localizing properties of a panel of MAbs. MAbs 81C6, C12, and D12 and 81C6 Fab have shown significant in vivo localization against HGCL D-54 MG and 81C6 against U-251 MG when compared to equivalent non-specific MAbs. In subcutaneous D-54 MG-

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Bernstein, S. H., V. L. Brunetto, F. R. Davey, et al. "Acute myeloid leukemia-type chemotherapy for newly diagnosed patients without antecedent cytopenias having myelodysplastic syndrome as defined by French-American-British criteria: a Cancer and Leukemia Group B Study." Journal of Clinical Oncology 14, no. 9 (1996): 2486–94. http://dx.doi.org/10.1200/jco.1996.14.9.2486.

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PURPOSE To determine the treatment outcome of standard acute myeloid leukemia (AML)-type chemotherapy in a subset of patients with newly diagnosed myelodysplastic syndromes (MDS) compared with that of patients with de novo AML as defined using French-American-British (FAB) criteria. In addition, to determine the pretreatment variables having prognostic significance for treatment outcome in patients with MDS. PATIENTS AND METHODS Nine hundred seven newly diagnosed patients with no history of cytopenias having a local institutional de novo AML successfully karyotyped and treated on Cancer and Le

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Ntlholang, Ontefetse, Kevin McCarroll, Eamon Laird, et al. "The relationship between adiposity and cognitive function in a large community-dwelling population: data from the Trinity Ulster Department of Agriculture (TUDA) ageing cohort study." British Journal of Nutrition 120, no. 5 (2018): 517–27. http://dx.doi.org/10.1017/s0007114518001848.

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AbstractPrevious reports investigating adiposity and cognitive function in the population allude to a negative association, although the relationship in older adults is unclear. The aim of this study was to investigate the association of adiposity (BMI and waist:hip ratio (WHR)) with cognitive function in community-dwelling older adults (≥60 years). Participants included 5186 adults from the Trinity Ulster Department of Agriculture ageing cohort study. Neuropsychological assessment measures included the Mini-Mental State Examination (MMSE), Frontal Assessment Battery (FAB) and Repeatable Batte

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Stadler, Herbert, Sabine Przibilla, Stefan Dreher, Christian Stemberger, Lothar Germeroth, and Dirk Busch. "Rapid and Effective Isolation Of (T) Cell Populations By a New Method Avoiding Magnetic Beads." Blood 122, no. 21 (2013): 4830. http://dx.doi.org/10.1182/blood.v122.21.4830.4830.

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In the last two decades, conventional isolation of therapeutic cells has been carried out using high affinity antibodies and magnetic bead technology. Although good purity and reasonable yields can be obtained in many cases, major disadvantages remain comprising biological interference of non-reversible selection reagents (e.g. stimulation, receptor blockade etc.), the difficulty to purify complex multi-parametric cell populations by positive selection, time consuming protocols as well as limitations in high-throughput processing. We report here on the development of a new non-magnetic and fas

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J.A, Ayo, Ibrahim A.G, Kundam D.N, Aondona M.M, Osabo P, and Maji B.D. "Chemical Composition, Functional and Sensory Qualities of Madidi Produced From Millet (Panicum Miliaceum), Sorghum (Sorghum Bicolor), Rice (Oryza Sativa), and Acha (Digitaria Exilis) Flour." Journal of food and Biotechnology 6, no. 1 (2025): 15–21. https://doi.org/10.51470/fab.2025.6.1.15.

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Madidi, a thick gruel food product commonly consumed as a snack or meal, is referred to by different names across Nigeria, including Eko in the Southwest, Agidi in the Southeast, and Madidi in the Northern and Central regions. Traditionally, the production of Madidi has relied heavily on millet, despite the underutilization of other locally available cereal grains. Therefore, there is a pressing need to explore and incorporate alternative cereals in Madidi production. This study investigates the preparation of Madidi from millet, sorghum, rice, and acha flour/grains using the local production

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Isnaniah, Siti, Dian Uswatun Hasanah, and Endang Rahmawati. "PELATIHAN PENULISAN ARTIKEL POPULER BERBASIS KEARIFAN LOKAL BAGI MASYARAKAT KARANGANYAR JAWA TENGAH." Dimasatra 2, no. 1 (2022): 29–44. http://dx.doi.org/10.17509/dm.v2i1.47505.

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The people of Karanganyar, Central Java, have a high enthusiasm for writing literacy culture, one of which is the writing community of Forum Lingkar Pena (FLP), which always carries civilization by writing to provide enlightenment to the community. Their enthusiasm still needs to be honed because their writings are not fully in accordance with the guidelines for writing popular articles. Therefore, the TBI FAB IAIN Surakarta Study Program organizes Community Service (PkM) activities in the form of training in writing popular articles about local wisdom for the community. This activity aims to

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Nolte, D., R. Hecht, P. Schmid, et al. "Role of Mac-1 and ICAM-1 in ischemia-reperfusion injury in a microcirculation model of BALB/C mice." American Journal of Physiology-Heart and Circulatory Physiology 267, no. 4 (1994): H1320—H1328. http://dx.doi.org/10.1152/ajpheart.1994.267.4.h1320.

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The leukocyte beta 2-integrin Mac-1 (CD11b/CD18) and its endothelial ligand intercellular adhesion molecule 1 (ICAM-1) are involved in leukocyte adhesion to and macromolecular leakage from postcapillary venules during inflammatory reactions. Both events are also encountered after ischemia-reperfusion of striated muscle, suggesting a central role of both adhesion proteins in reperfusion injury. Using intravital fluorescence microscopy and a microcirculation model in awake BALB/C mice, we investigated the effects of monoclonal antibodies (MAb) and Fab fragments to Mac-1 and MAb to ICAM-1 on leuk

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Kyrchanova, Olga, Vladimir Sokolov, Maxim Tikhonov, Galya Manukyan, Paul Schedl, and Pavel Georgiev. "Transcriptional Readthrough Interrupts Boundary Function in Drosophila." International Journal of Molecular Sciences 24, no. 14 (2023): 11368. http://dx.doi.org/10.3390/ijms241411368.

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In higher eukaryotes, distance enhancer-promoter interactions are organized by topologically associated domains, tethering elements, and chromatin insulators/boundaries. While insulators/boundaries play a central role in chromosome organization, the mechanisms regulating their functions are largely unknown. In the studies reported here, we have taken advantage of the well-characterized Drosophila bithorax complex (BX-C) to study one potential mechanism for controlling boundary function. The regulatory domains of BX-C are flanked by boundaries, which block crosstalk with their neighboring domai

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Cairo, Mitchell S., Mary Gerrard, Richard Sposto, et al. "Results of a randomized international study of high-risk central nervous system B non-Hodgkin lymphoma and B acute lymphoblastic leukemia in children and adolescents." Blood 109, no. 7 (2006): 2736–43. http://dx.doi.org/10.1182/blood-2006-07-036665.

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Abstract The prognosis for higher risk childhood B-cell non-Hodgkin lymphoma has improved over the past 20 years but the optimal intensity of treatment has yet to be determined. Children 21 years old or younger with newly diagnosed B-cell non-Hodgkin lymphoma/B-cell acute lymphoblastic leukemia (B-NHL/B-ALL) with higher risk factors (bone marrow [BM] with or without CNS involvement) were randomized to standard intensity French-American-British/Lymphoma Malignancy B (FAB/LMB) therapy or reduced intensity (reduced cytarabine plus etoposide and deletion of 3 maintenance courses M2, M3, M4). All p

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Bronfman, Paulina. "Narratives of Rebellion: Memories and prefiguration in the work of Fab Ciraolo during Chile’s October uprising." Art & the Public Sphere 13, no. 1 (2024): 107–22. https://doi.org/10.1386/aps_00103_1.

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Artistic activism has become a central element for political change in Chile. In 2019, during Chile’s October uprising, graffiti and muralism were at the centre of the street protests. Taking concepts of memory and prefiguration as a theoretical framework, this article examines how visual artist Fab Ciraolo created his narratives of rebellion during October’s uprising and, in turn, posits the potential of contemporary Chilean graffiti and muralism as a repertoire of political action. This article explores the inspiration that social movements have gained from these types of artistic practices

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Huang, Bing S., Baoxue Yuan, and Frans HH Leenen. "Chronic blockade of brain "ouabain" prevents sympathetic hyper-reactivity and impairment of acute baroreflex resetting in rats with congestive heart failure." Canadian Journal of Physiology and Pharmacology 78, no. 1 (1999): 45–53. http://dx.doi.org/10.1139/y99-115.

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In rats with congestive heart failure (CHF) post myocardial infarction (MI) acute blockade of brain "ouabain" reverses sympathetic hyperactivity and chronic blockade prevents the desensitization of baroreflex function. This study was conducted to determine: i) if chronic blockade of brain "ouabain" maintains normal sympathetic reactivity; andii) if acute baroreflex resetting (another parameter of baroreflex function) also becomes impaired, and if so, does brain "ouabain" contribute to impairment in acute baroreflex resetting. CHF post MI was induced by acute coronary artery ligation in Wistar

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Kandhadi, Jaipal, Ravi Kumar Kanaparthi, and Lingamallu Giribabu. "Germanium(IV) phthalocyanine-porphyrin based hetero trimers: synthesis, spectroscopy and photochemistry." Journal of Porphyrins and Phthalocyanines 16, no. 03 (2012): 282–89. http://dx.doi.org/10.1142/s1088424612500319.

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The known oxophilicity of Germanium(IV) ion of Germanium(IV) phthalocyanine and porphyrins have been exploited to synthesize functionally active, "axial-bonding" -type hetero oligomers. These hetero trimers have been fully characterized by elemental analysis, FAB-MS, UV-visible, proton nuclear magnetic resonance (1D and 1 H -1 H COSY) and fluorescence spectroscopies, as well as differential pulse voltammetric method. Comparison of their spectroscopic and electrochemical data with those of the corresponding individual constituents reveals that there is no apparent π–π interactions in these "ver

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Wenthold, R. J., K. K. Skaggs, and R. R. Reale. "Characterization of retrograde axonal transport of antibodies in central and peripheral neurons." Journal of Histochemistry & Cytochemistry 34, no. 3 (1986): 373–80. http://dx.doi.org/10.1177/34.3.3950386.

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Retrograde axonal transport of antibodies against synaptic membrane glycoproteins was studied in the hypoglossal nerve and several CNS pathways of the rat. Injection into the tongue of polyclonal antibodies against synaptic membrane glycoproteins produced immunocytochemically labeled cells in the hypoglossal nucleus 4-5 hr later. Immunoreactive staining increased through 48 hr after injection and then declined. Injections of Fab preparations of the antibody gave labeling patterns indistinguishable from those of the whole antibody. The specificity of this method is shown by control studies in w

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Kubalek, E., S. Ralston, J. Lindstrom, and N. Unwin. "Location of subunits within the acetylcholine receptor by electron image analysis of tubular crystals from Torpedo marmorata." Journal of Cell Biology 105, no. 1 (1987): 9–18. http://dx.doi.org/10.1083/jcb.105.1.9.

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The binding sites on the nicotinic acetylcholine receptor of labels specific for the alpha-, beta-, and delta-subunits were determined by electron image analysis, using tubular crystals of receptors grown from the postsynaptic membranes of Torpedo marmorata electric organ. The labels were alpha-bungarotoxin (which attaches to the acetylcholine binding sites on the pair of alpha-subunits), Fab35 (a monoclonal antibody Fab fragment directed against the main immunogenic region of the alpha-subunit), Fab111 (a monoclonal antibody Fab fragment directed against a cytoplasmic site on the beta-subunit

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Pulsoni, Alessandro, Massimo Breccia, Sonia Maria Orlando, et al. "Acute Erythroid Leukemia: A Distinctive Subtype of AML? Outcome and Prognostic Factors in Comparison with Non-M6 AML. The Gimema Experience." Blood 114, no. 22 (2009): 1019. http://dx.doi.org/10.1182/blood.v114.22.1019.1019.

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Abstract Abstract 1019 Poster Board I-41 INTRODUCTION: Erythroleukemia is characterized by a peculiar marrow feature: a proliferation of erythroblasts greater than 50% and of myeloblasts greater than 30%, according to the FAB classification. Treatment strategies are usually indistinct from other forms of acute myeloid leukemia (AML), with the exception of acute promyelocytic leukemia. Although generally considered as a very aggressive subtype of AML, very few data are available concerning epidemiologic features and specific outcome of erythroleukemia among AMLs. MATERIALS AND METHODs: Adult pa

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Dorofeeva, Ganna S., and Yuriy Yu Kobelyatskyy. "Effect of regional anesthesia as a component of multimodal pain relief on the cognitive status of patients in ophthalmic surgery." Regional Anesthesia and Acute Pain Management 15, no. 1 (2021): 49–56. http://dx.doi.org/10.17816/1993-6508-2021-15-1-49-56.

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This article examines and analyzes the dependence of the state of the central nervous system (CNS) in the postoperative period in patients who underwent penetrating keratoplasty. MATERIAL AND METHODS: The analysis of cognitive status was performed using neuropsychological testing involving the scale of frontal dysfunctions (Frontal Assessment BatteryFAB) and a short scale for assessing mental status (Mini-Mental State ExaminationMMSE). The results were assessed on the eve of the operation, 6 h after the operation, and 7 and 21 days after the operation. Depending on the applied method of

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Chichanovskaya, L. V., T. A. Slyusar, T. M. Nekrasova, I. N. Slyusar, A. R. Podborsky, and A. G. Flax. "Clinical, psychological and neuroimaging characteristics of chronic tension headache in elderly persons." Medical alphabet, no. 1 (March 3, 2022): 54–59. http://dx.doi.org/10.33667/2078-5631-2022-1-54-59.

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The aim of the study. To study clinical, psychological and neuroimaging characteristics of chronic tension headache (CTH) in the elderly.Materials and methods. 92 patients with CHTHN (37 men and 55 women aged 55–74 years) were examined. The control group consisted of 53 people (22 men and 31 women of the same age) who did not have neurological complaints, including headache. Pain intensity was assessed on a 10-point visual analogue scale. The severity of neurological symptoms was determined using the NIH-NINDS scale. For the study of cognitive functions, a short scale for assessing mental stat

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Shen, Mengyue, Yan-Ling Pi, Zhenlan Li, et al. "The Feasibility and Positive Effects of Wuqinxi Exercise on the Cognitive and Motor Functions of Patients with Parkinson’s Disease: A Pilot Study." Evidence-Based Complementary and Alternative Medicine 2021 (March 29, 2021): 1–7. http://dx.doi.org/10.1155/2021/8833736.

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Introduction. Parkinson’s disease (PD) is a chronic degenerative disease of the central nervous system common in middle-aged and elderly people, which has a serious impact on patients’ cognitive and motor functions. Exercise can improve the nonmotor symptoms of PD patients, but the optimal type of exercise for the cognitive function of patients is unclear. Therefore, the purpose of this study is the impact of 12 weeks of Wuqinxi exercise on the cognitive and motor function in PD patients. Methods. Thirty PD patients participated in the study and were randomly assigned to two groups: Wuqinxi gr

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Žibrat Gašparič, Andreja, Milena Horvat, and Breda Mirtič. "Ceramic petrography, mineralogy and typology of Eneolithic pottery from Krašnja, Slovenia." Documenta Praehistorica 41 (December 30, 2014): 226–36. http://dx.doi.org/10.4312/dp.41.12.

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In this article, we present newly excavated Eneolithic pottery from the site at Krašnja near Lukovica in central Slovenia. The material was AMS 14C dated and is contemporaneous with archaeological sites from the Ljubljansko barje region in Slovenia. The vessels were reconstructed and then various types of pots, dishes, cups, and beakers were analysed using petrography and the X-ray diffraction method. Additionally, the clay remains of walls and the floor of an Eneolithic kiln excavated at the site were also analysed. The results show that Eneolithic potters used different fab- rics to make ves

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Audino, Anthony N., Stanton Goldman, Matthew J. Barth, et al. "Multicenter Pilot Trial of Intrathecal Liposomal Cytarabine Combined with FAB Chemoimmunotherapy with Reduced Doxorubicin in CAYA with Mature De-Novo B-NHL." Blood 142, Supplement 1 (2023): 1727. http://dx.doi.org/10.1182/blood-2023-181756.

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Background: Children, adolescents, and young adults (C-AYA) with newly diagnosed advanced Mature B Non-Hodgkin Lymphoma (MB-NHL), specifically Burkitt Lymphoma (BL) and Diffuse Large B Cell Lymphoma (DLBCL), have achieved ≥ 90% overall survival with multi-agent chemotherapy and intrathecal chemotherapy (IT) without central nervous system (CNS) radiation (Cairo et al., Blood 2007; Goldman/Cairo et al., BJH 2014; Frazier/Cairo, et al., BJH 2014; Minard-Colin, et al., NEJM 2020). Standard therapy includes short but intensive courses of multiagent chemotherapy including CNS-penetrating high dose m

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