Relevant bibliographies by topics / Central nervous system Meningitis in children

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers

Academic literature on the topic 'Central nervous system Meningitis in children'

Author: Grafiati
Published: 4 June 2021
Last updated: 1 February 2022

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Journal articles on the topic "Central nervous system Meningitis in children"

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Janowski, Andrew B., and Jason G. Newland. "From the microbiome to the central nervous system, an update on the epidemiology and pathogenesis of bacterial meningitis in childhood." F1000Research 6 (January 27, 2017): 86. http://dx.doi.org/10.12688/f1000research.8533.1.

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In the past century, advances in antibiotics and vaccination have dramatically altered the incidence and clinical outcomes of bacterial meningitis. We review the shifting epidemiology of meningitis in children, including after the implementation of vaccines that target common meningitic pathogens and the introduction of intrapartum antibiotic prophylaxis offered to mothers colonized withStreptococcus agalactiae. We also discuss what is currently known about the pathogenesis of meningitis. Recent studies of the human microbiome have illustrated dynamic relationships of bacterial and viral popul
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Ahmed, Amina. "Treatment of Central Nervous System Tuberculosis." Journal of Pediatric Infectious Diseases 13, no. 02 (2018): 141–52. http://dx.doi.org/10.1055/s-0037-1607235.

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AbstractCentral nervous system tuberculosis (CNS-TB) manifests as tuberculous meningitis, intracranial tuberculoma, or spinal tuberculous arachnoiditis. Children are disproportionately affected, with high rates of mortality and morbidity reported even in the era of treatment. Most guidelines for the treatment of drug-susceptible CNS-TB recommend 9 to 12 months of a standard regimen of isoniazid, rifampin, pyrazinamide, and ethambutol, with the adjunctive use of corticosteroids early in therapy. Recent trials have demonstrated improved outcomes with intensified regimens using nonstandard regime
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Andreeva, I. G., R. N. Mamleev, A. D. Evdokimova, and A. F. Galiullina. "Neurological complications of acute otitis media in children." Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics) 64, no. 5 (2019): 250–55. http://dx.doi.org/10.21508/1027-4065-2019-64-5-250-255.

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The complications of acute otitis media remain an unsolved problem in pediatrics, as they often lead to disability of children. The damage to the nervous system is the most dramatic complications of acute purulent otitis media. Neurological complications include both intracranial lesions of the central nervous system (meningitis, encephalitis, brain abscesses) and neuropathy of the cranial nerves. We presented clinical cases of various neurological complications of otitis media, analyzed diagnostic and therapeutic errors and showed the ways to solve this difficult problem.
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Rahaman, Sk Rafikul, Anshuman Panda, Pradyut K. Mandal, Kripasindhu Chatterjee, and R. V. Borgaonkar. "Adenosine deaminase activity in cerebrospinal fluid: diagnostic investigation in central nervous system disorders in children." International Journal of Contemporary Pediatrics 4, no. 2 (2017): 596. http://dx.doi.org/10.18203/2349-3291.ijcp20170716.

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Background: Tubercular meningitis (TBM) is an endemic disease in developing countries. Adenosine deaminase activity (ADA) has been of great importance for many years in TBM diagnosis. The objective of this study was to determine the CSF-ADA levels in different CNS disorders, to compare the CSF-ADA activity in different types of meningitis, to find out the sensitivity and specificity of CSF-ADA in the diagnosis of TBM and to establish the prognostic value of CSF-ADA in TBM in comparison to Control group.Methods: For control group CSF was collected from the patients of simple febrile convulsions
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Volotko L. O. "NEUROSONOGRAPHIC STUDY OF CHILDREN WITH HYPOXIC-ISCHEMIC BRAIN IJURY." Science Review, no. 4(31) (April 30, 2020): 7–11. http://dx.doi.org/10.31435/rsglobal_sr/30042020/7050.

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The study is aimed at neurosonographic characteristics of brain injury in newborn patients with perinatal hypoxic-ischemic injury of central nervous system, complicated with inflectional process (meningitis, ventriculitis). It is settled that brain immaturity, hydrocephalic syndrome, ischemia of the brain tissue and intraventricular hemorrhages are found 2 times more often in infants with perinatal hypoxic-ischemic injury of central nervous system, complicated with inflectional process. This fact generally characterizes disorders of the hemato-encephalic barrier and the development of destruct
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Jawad, Aiyar Shakir. "Spectrum of central nervous system infections in neurosciences hospital in two years : a retrospective study." AL-Kindy College Medical Journal 16, no. 1 (2020): 67–73. http://dx.doi.org/10.47723/kcmj.v16i1.197.

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Background :Infectious disorders in general have high morbidity and mortality.. CNS infections include many disorders like bacterial meningitis, tuberculous and other subacute and chronic meningitis, viral meningitis, cerebral abscess, spinal cord infections, and others.Objective: To assess our locality about prevalence of CNS infections , to have more awareness regarding CNS infections, and to try to find the proper way to reduce their prevalence and to treat them in appropriate way.Method :We revised the records of all the cases of CNS infections excluding cases of spinal cord infections who
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Bahtera, Tjipta, Bagus Putu Ngurah Arsana, and Maria Lidwina. "Early Ditection of Central Nervous System Infection by C-reactive Protein Examination of Cerebrospinal Fluid." Paediatrica Indonesiana 32, no. 5-6 (2019): 144–52. http://dx.doi.org/10.14238/pi32.5-6.1992.144-52.

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There are still many cases of bacterial meningitis in Indonesia. The highest morbidity rate are between 2 months until 2 years of age. The important factors that influence the success of treatment are early diagnosis and detection of the cause. C-reactive protein (=CRP) could be found in the spinal fluid of meningitis patients. The aim of this study is to judge the ability of CRP as a tool in making diagnosis as soon as possible whether there is a bacterial infection of the central nervous system and to compare it with the result of the spinal fluid culture. Also to compare the ability of it a
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Gupta, Sanjay, Shobhan Vachhrajani, Abhaya V. Kulkarni, et al. "Neurosurgical management of extraaxial central nervous system infections in children." Journal of Neurosurgery: Pediatrics 7, no. 5 (2011): 441–51. http://dx.doi.org/10.3171/2011.2.peds09500.

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Object Extraaxial infections of the CNS, including subdural empyema and epidural abscess, are rare but potentially life-threatening conditions. Symptoms are usually progressive, and early diagnosis is therefore important. Early intervention with appropriate treatment offers the best opportunity for eradicating the infection and promoting maximal neurological recovery. Methods The medical records of children with extraaxial CNS infection over the last 24 years at the Hospital for Sick Children were analyzed. Only those patients with radiological and/or operative confirmation of the diagnosis of
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Liberalesso, Paulo Breno Noronha, Izabella Celidônio Bertoldo da Silva, Karlin Fabianne Klagenberg, Ari Leon Jurkiewicz, Bianca Simone Zeigelboim, and Victor Horácio Costa Júnior. "Incidence and risk factors for seizures in central nervous system infections in childhood." Journal of Epilepsy and Clinical Neurophysiology 15, no. 2 (2009): 83–88. http://dx.doi.org/10.1590/s1676-26492009000200007.

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INTRODUCTION: The infections of the central nervous system remain as a public health problem in several countries and there is a direct relation between poverty and underdevelopment with high mortality and morbidity rates. Seizures represents a complication related to infections of the central nervous system, are considered a clinical emergency and requiring neurological investigation. OBJECTIVE: In this article, we propose to describe the incidence and risk factors for seizures in central nervous system infections in childhood. METHODS: a retrospective study was performed between October 2007
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Калоева, Zinaida Kaloeva, Гуссоева, et al. "Clinical and epidemiological features and residual manifestations of serous enteroviralmeningitis in children in North Ossetia-Alania." Vladikavkaz Medico-Biological Bulletin 21, no. 32 (2016): 46–51. http://dx.doi.org/10.12737/18547.

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The article presents the analysis of the epidemiological, clinical and laboratory features of serous meningitis enteroviral etiology in children hospitalized at the RCCH of Vladikavkaz in 2008–2012. We have also studied the residual manifestations of enteroviral meningitis in 44 patients in the early period of convalescence. The study showed that of RNO-Alania typical summer – autumn seasonality of serous meningitis enteroviral etiology in children. The central nervous system caused by enteroviruses more often develops in children of preschool and school age. The clinical picture of enterovira
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Dissertations / Theses on the topic "Central nervous system Meningitis in children"

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Carlini, Sophia Magdalena. "Adenylate kinase values in cerebrospinal fluid as a marker to predict neurological outcome in children with meningitis." Thesis, Cape Technikon, 1997. http://hdl.handle.net/20.500.11838/1456.

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Thesis (Master's Diploma(Technology (Medical Technology))-- Cape Technikon, 1997<br>Meningitis in children is a common and serious disease. Bacterial and tuberculous meningitis often lead to neurological complications. A sensitive marker to predict brain damage in children with meningitis could be of great importance. Frithz F et aI, 1982 suggested that increased adenylate kinase values could indeed be used as a marker for brain damage. Adenylate kinase (AK) is an enzyme present in brain tissue. Low concentrations are present in normal cerebrospinal fluid (CSF) « 1 uti). Increased concentrat
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Ryder, Stephen J. "Studies on the recruitment of macrophages into the central nervous system." Thesis, University of Cambridge, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.309144.

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Tager, Dany, Anne Hatch, Jennifer Segar, Brentin Roller, Mohajer Mayar Al, and Tirdad T. Zangeneh. "Coccidioidal meningitis complicated by central nervous system vasculitis in a patient with leukemia." ELSEVIER SCIENCE BV, 2017. http://hdl.handle.net/10150/625216.

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Central Nervous System (CNS) vasculitis is the most common life-threatening complication of coccidioidal meningitis. It is manifested by cerebral ischemia, hemorrhage, and infarction. We report a case of CNS vasculitis in a patient receiving chemotherapy and review of the literature on coccidioidal meningitis. The patient was treated with combination antifungal therapy and a short course of high dose corticosteroids with a modest improvement in her neurological examination after initiation of steroids.
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Stanley, Alan Michael. "The utility of CSF PCR in central nervous system Varicella zoster infection in HIV." Master's thesis, University of Cape Town, 2015. http://hdl.handle.net/11427/16778.

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Includes bibliographical references<br>Aims: To assess the clinical and cerebrospinal fluid characteristics, and the role of tuberculous meningitis (TBM) as a confounder, in a cohort of HIV positive individuals with positive varicella zoster virus (VZV) positive cerebrospinal fluid PCR. Methods: Patients in the NHLS database at Groote Schuur Hospital with positive CSF VZV PCR who were also HIV co-infected and whose folders were available for clinical review were reviewed. Clinical and biochemical data were collected. Patients were divided into two groups based an accepted case definition for T
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Abdalla, Hana Khidir. "Modulation of inflammatory mediators during experimental bacterial meningitis /." Linköping : Department of Molecular and Clinical Medicine, Linköping university, 2005. http://www.bibl.liu.se/liupubl/disp/disp2005/med907s.pdf.

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Pelegrín, Senent Iván. "Clinical approach and management of bacterial infections of the central nervous system related to hydrocephalus." Doctoral thesis, Universitat de Barcelona, 2017. http://hdl.handle.net/10803/585886.

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INTRODUCTION: Community-acquired bacterial meningitis is a relevant entity related to a high morbidity and mortality, despite of the adjuvant and antibiotic treatments available. Morbidity and mortality are caused by neurological complications, being hydrocephalus one of the less investigated one and related to Listeria monocytogenes meningoencephalitis episodes, which increase have been reported in the last decade. Moreover, the devices used for treatment of hydrocephalus have a high risk of infection. These infections have a high personal and economic costs, and their prevention and treatme
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Saba, Villarroel Paola Mariela. "Epidemiology of central nervous system infections and of Zika virus in Bolivia." Thesis, Aix-Marseille, 2020. http://theses.univ-amu.fr.lama.univ-amu.fr/200424_SABAVILLARROEL_796lerwvy638nrfmjn965osdp469z_TH.pdf.

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Nous avons réalisé une étude prospective (nov-2017 à oct-2018) chez des patients boliviens hospitalisés suspectés d'infection du SNC pour identifier les plus courants étiologies et orienter les stratégies de diagnostic, de traitement, de prévention et de santé publique. Nous avons recruté 257 patients hospitalisés (20,2% VIH positifs), une étiologie infectieuse a été confirmée chez 49,8% des patients. Les principales étiologies chez les patients VIH positifs étaient Cryptococcus spp. (41,7%) et M. tuberculosis (27,8%) et chez les patients VIH négatifs, M. tuberculosis (26,1%) et S. pneumoniae
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Kihara, Michael. "Neurocognitive impairment following central nervous system infections in Kenyan children as detected by event related potentials." Thesis, Open University, 2008. http://oro.open.ac.uk/54642/.

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As mortality in childhood decreases due to advances in modern medicine, presence of better nutrition and fresh water supply, the impact of disability has become increasingly important especially in resource poor countries. Children living in sub- Saharan Africa are also exposed to a number of potentially debilitating infections which have been shown to have long-term cognitive effects even in absence of clinical neurological sequelae. The objective of the study is to demonstrate that event related potentials (ERPs) can be used to detect neurocognitive impairment following the most common centr
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Nunes, Rafaella Almeida Lima. "Aplicação de técnicas moleculares no diagnóstico laboratorial complementar das infecções virais do sistema nervoso central no Hospital Universitário da USP." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/42/42132/tde-19032014-160513/.

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Enterovírus (HEV), herpesvírus 1 e 2 (HHV-1 e HHV-2) e adenovírus (HAdV) são importantes agentes de infecções do SNC. Neste trabalho, técnicas moleculares foram aplicadas para a detecção destes vírus em quadros de infecção do SNC. Amostras de líquor foram colhidas de pacientes atendidos no HU-USP entre agosto e novembro/2010 e fevereiro/2012 a janeiro/2013. Através da Nested-PCR HEV foram detectados em 9,8% das amostras, HAdV em 2,5% e HHV-1 e 2 em 1,1%, além de 3 casos de coinfecção, 2 entre HEV e HHV, e 1 entre HEV e HAdV. O material genético viral foi extraído através dos métodos Qiaamp DNA
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Nunes, Cristina Freitas. "Etiologia das encefalites e meningites de líquor claro." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/99/99131/tde-27112018-144215/.

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Infecções no sistema nervoso central (SNC) causadas por microrganismos desencadeiam sintomas de moderados a severos, dependendo da região atingida, podendo ser designadas como encefalites ou meningites. Os vírus são os agentes mais comuns nestas infecções. Os agentes virais responsáveis por essas enfermidades que apresentam maior incidência na população mundial são certos herpesvírus, flavivírus, influenza A, enterovírus e vírus da caxumba. Entretanto, essa prevalência varia de acordo com a população, estado imunológico do indivíduo, idade e região estudada. Embora existam dados bem estabeleci
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Books on the topic "Central nervous system Meningitis in children"

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Britain), SCOPE (Great, ed. CNS magnetic resonance imaging in infants and children. MacKeith Press, 1995.

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Faerber, Eric N. CNS magnetic resonance imaging in infants and children. MacKeith Press, 1995.

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Neurobehavioral and perceptual dysfunction in learning disabled children. C.J. Hogrefe, 1985.

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Virgilio, Gallai, ed. Maturation of the CNS and evoked potentials: Proceedings of the International Congress on Maturation of the Central Nervous System and Clinical Applications of Cerebral Evoked Potentials in Children, Perugia, 21-24 May 1986. Excerpta Medica, 1986.

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Catherine, Bagwell, and Erkulwater Jennifer L, eds. Medicating children: ADHD and pediatric mental health. Harvard University Press, 2008.

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Conference on Brain and Behavior in Pediatric HIV Infection (1989 New York, N.Y.). Brain in pediatric AIDS: Proceedings of the Conference on Brain and Behavior in Pediatric HIV Infection, New York, N.Y., July 24-25, 1989. Edited by Kozlowski Piotr B. 1950-. Karger, 1990.

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Current issues in clinical neurovirology: Pathogenesis, diagnosis and treatment. Saunders, 2008.

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Catherine, Mollica, and Maruff Paul, eds. Cognitive impairment in children with ADHD. Nova Science, 2010.

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Handbook of learning disabilities: A multisystem approach. Allyn and Bacon, 1990.

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Cruz, Andrea T., and Jeffrey R. Starke. Central Nervous System Tuberculosis. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199937837.003.0154.

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Mycobacterium tuberculosis is a common cause of bacterial meningitis in areas with high HIV prevalence and its diagnosis often is delayed in industrialized nations. Children (particularly infants) and immunocompromised persons are at higher risk of developing TB meningitis. Lymphocytic meningitis, high CSF protein, and (in children) frequently an abnormal chest radiograph should raise clinician index of suspicion for TB meningitis. Neuroimaging may show hydrocephalus, basilar leptomeningeal enhancement, ischemia, and/or tuberculomas. Prompt recognition and initiation of antituberculous antibio
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Book chapters on the topic "Central nervous system Meningitis in children"

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Bodman, Alexa, and Walter A. Hall. "Meningitis and Meningoencephalitis." In Fungal Infections of the Central Nervous System. Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-06088-6_17.

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Malhotra, Hardeep Singh, and Ravindra K. Garg. "Vascular Complications of Tuberculous Meningitis." In Tuberculosis of the Central Nervous System. Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-50712-5_12.

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Schmutzhard, Erich, Ulrich Roelcke, and Thomas P. Bleck. "Tuberculous Meningitis and Central Nervous System Tuberculosis." In Neurocritical Care. Springer Berlin Heidelberg, 1994. http://dx.doi.org/10.1007/978-3-642-87602-8_37.

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Jain, Amita. "Methods of Microbiological Confirmation in Tuberculous Meningitis." In Tuberculosis of the Central Nervous System. Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-50712-5_26.

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Figaji, Anthony, Graham Fieggen, and Ursula Rohlwink. "Hydrocephalus Surgery in Childhood Tuberculous Meningitis with Hydrocephalus." In Tuberculosis of the Central Nervous System. Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-50712-5_29.

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Bloom, H. J. G. "Tumours of the Central Nervous System." In Cancer in Children. Springer Berlin Heidelberg, 1986. http://dx.doi.org/10.1007/978-3-642-96889-1_20.

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Tait, D. M., C. C. Bailey, and M. M. Cameron. "Tumours of the Central Nervous System." In Cancer in Children. Springer Berlin Heidelberg, 1992. http://dx.doi.org/10.1007/978-3-642-84722-6_17.

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Parker, Whitney E., Shahiba Q. Ogilvie, Lily McLaughlin, and Mark M. Souweidane. "Management of Solid Tumor CNS Metastases in Children." In Central Nervous System Metastases. Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-42958-4_18.

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Yadav, Y. R., Nishtha Yadav, Vijay Parihar, Shailendra Ratre, and Jitin Bajaj. "Role of Endoscopic Third Ventriculostomy in Tuberculous Meningitis with Hydrocephalus." In Tuberculosis of the Central Nervous System. Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-50712-5_30.

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Tlili-Graiess, Kalthoum, Nadia Mama-Larbi, Nadine Girard, and Charles Raybaud. "Central Nervous System Vasculitis in Children." In Systemic Vasculitis. Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/174_2011_354.

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Conference papers on the topic "Central nervous system Meningitis in children"

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Saliou, G., M. Eyries, M. Iacobucci, et al. "Clinical and Molecular Findings in a Cohort of Children with Central Nervous System Arteriovenous Fistulas." In Joint Annual Meeting 2017: Swiss Society of Neurosurgery, Swiss Society of Neuroradiology. Georg Thieme Verlag KG, 2017. http://dx.doi.org/10.1055/s-0037-1603839.

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Elmoneim, Abeer Abd, Ahlam Eladawy, Mona Abu Elkasem, and Soumaya Hadhood. "Abstract 4910: Neurocognitive effects of central nervous system directed chemotherapy in Non Hodgkin Lymphoma diseased children." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.sabcs18-4910.

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Elmoneim, Abeer Abd, Ahlam Eladawy, Mona Abu Elkasem, and Soumaya Hadhood. "Abstract 4910: Neurocognitive effects of central nervous system directed chemotherapy in Non Hodgkin Lymphoma diseased children." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.am2019-4910.

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Rayamajhi, A., and S. Sharma. "G440(P) Validation of world health organization definition of acute encephalitis syndrome with central nervous system infection in nepali children." In Royal College of Paediatrics and Child Health, Abstracts of the RCPCH Conference–Online, 25 September 2020–13 November 2020. BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health, 2020. http://dx.doi.org/10.1136/archdischild-2020-rcpch.381.

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Shvaikova, Irina N. "Of the application a vector-modeling and visual diagnostic images in the system of monitoring and diagnostics of pathology of the central nervous system at children." In EUROCON 2007 - The International Conference on "Computer as a Tool". IEEE, 2007. http://dx.doi.org/10.1109/eurcon.2007.4400525.

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Lefrere, J. J., D. Vittecoq, D. Gozin, and J. Modai. "CIRCULATING ANTICOAGULANT IN AIDS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644859.

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The frequency of a circulating anticoagulant has been reported to be high in AIDS, in particular in case of Pneumocystic carinii pneumonia (Pep). Twenty-five non-hemophiliac patients (23 homosexual males,1 drug addict, 1 tranfused) with AIDS were followed over a six month period. Mean age was 32 (21-42). All patients had a markedly decreased T4/T8 ratio (mean 0.12), a low absolute T4 level (mean : 155/mm3), an elevated total serum immunoglobulins level.Activated partial thromboplastin time (APTT), prothrombintime and thrombin time were measured once a week during hospitalisation. A prolonged A
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Khatua, Soumen, Vidya Gopalakrishnan, Laurence Cooper, et al. "Abstract CT033: Phase I study of intraventricular infusions of autologous exvivo expanded NK cells in children with recurrent/refractory malignant posterior fossa tumors of the central nervous system." In Proceedings: AACR Annual Meeting 2017; April 1-5, 2017; Washington, DC. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1538-7445.am2017-ct033.

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Khatua, Soumen, Dean Lee, Laurence Cooper, et al. "Abstract CT216: Phase I study of intraventricular infusions of autologous ex vivo expanded NK cells in children with recurrent/refractory malignant posterior fossa tumors of the central nervous system." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.sabcs18-ct216.

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Khatua, Soumen, Dean Lee, Laurence Cooper, et al. "Abstract CT216: Phase I study of intraventricular infusions of autologous ex vivo expanded NK cells in children with recurrent/refractory malignant posterior fossa tumors of the central nervous system." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.am2019-ct216.

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Hood, R. Lyle, Tobias Ecker, John Rossmeisl, John Robertson, and Christopher G. Rylander. "Improving Convection-Enhanced Delivery Through Photothermal Augmentation of Fluid Dispersal." In ASME 2012 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/sbc2012-80720.

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Malignant tumors of the central nervous system are the third leading cause of cancer-related deaths in adolescents and adults between the ages of 15 and 34; in children, brain tumors are the leading cause of cancer death. Convection-enhanced delivery (CED) has emerged as a promising method for the transport of high concentrations of chemotherapeutic macromolecules to brain tumors. CED is a minimally-invasive surgical procedure wherein a stereotactically-guided small-caliber catheter is inserted into the brain parenchyma, to a tumor site, for low flowrate infusion of chemotherapy [1]. This dire
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