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Journal articles on the topic 'Central odontogenic fibroma (COF)'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Maraimalai, Nivedhitha, Manisha Ahire Sardar, Shubhangi M. Patil, Yogita Adhane, Priyanka Pachpande, and Tabita Joy Chettiankandy. "Central odontogenic fibroma: A case report." Archives of Dental Research 13, no. 1 (2023): 45–48. http://dx.doi.org/10.18231/j.adr.2023.009.

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The central odontogenic fibroma (COF) is a rare benign odontogenic mesenchymal tumour of jaw bone derived from the odontogenic ectomesenchyme. It is characterized by a fibrous mature stroma with variable number of strands or islands of inactive-looking odontogenic epithelium. The presented case is a 46 years old male complaining of asymptomatic mandibular bony swelling. Radiographically, the lesion is unilocular radiolucent, with root resorption and displacement of teeth. Histopathology showed dense fibrous connective tissue stroma, loosely arranged with spindle and stellate-shaped mesenchymal

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2

Thankappan, Prasanth, Naga Sirisha V. Chundru, Rajesh Amudala, Prashanthi Yanadi, S. A. K. Uroof Rahamthullah, and Meeramma Botu. "Central Odontogenic Fibroma of Simple Type." Case Reports in Dentistry 2014 (2014): 1–3. http://dx.doi.org/10.1155/2014/642905.

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Central odontogenic fibroma (COF) is an extremely rare benign tumor that accounts for 0.1% of all odontogenic tumors. It is a lesion associated with the crown of an unerupted tooth resembling dentigerous cyst. In this report, a 10-year-old male patient is presented, who was diagnosed with central odontogenic fibroma of simple type from clinical, radiological, and histopathological findings.

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3

Bennabi, Sabrina, Philippe Lesclous, and Alexandra Cloitre. "Central Odontogenic Fibroma: characteristics and management." Journal of Oral Medicine and Oral Surgery 27, no. 2 (2021): 25. http://dx.doi.org/10.1051/mbcb/2020066.

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Introduction: Central Odontogenic Fibroma (COF) is a rare benign odontogenic tumour of the jaws. Until its recent change in classification by the WHO in 2017, this entity has gone without an agreed upon definition for many years. For this reason, COF would remain largely unknown to practitioners. Corpus: The pedagogical objectives of this article are, through a systematic review of the literature using the PRISMA methodology, to list the epidemiological, aetiological, clinical, radiological, histological, therapeutic and prognostic characteristics of COF. All the data collected made it possibl

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4

Vinita V, Belure, Baron Tarun Kumar A, Gowda Triveni M, and Mehta Dhoom S. "A typical Odontogenic Neoplasm: Peripheral Odontogenic Fibroma." RGUHS Journal of Dental Sciences 9, no. 2 (2017): 35–38. http://dx.doi.org/10.26715/rjds.9_2_7.

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There appears to be similarities between the clinical appearances of different types of gingival overgrowths. The WHO type peripheral odontogenic fibroma (POdF) is an unusual benign odontogenic neoplasma of the gingiva. It is considered to be an extraosseous counterpart of the central odontogenic fibroma (COF). Among all biopsy specimens, POdF comprehend only upto 0.05%. Odontogenic fibromas are rare but still they provide a noteworthy diagnostic and therapeutic challenge. Along with clinical, radiographic appearance, and histologic features, a sound knowledge on biologic behavior of rare ging

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5

Vakili Saatloo, Maedeh. "Hybrid Central Odontogenic Fibroma/ Central Giant Cell Lesion of the Mandible: A case Report and Review of the Literature." Open Access Journal of Dental and Oral Surgery (OAJDOS) 4, no. 4 (2023): 1–5. http://dx.doi.org/10.54026/oajdos/1069.

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Central odontogenic fibroma (COF) is a rare neoplasm of the jaw. The combination of COF and Central Giant Cell Granuloma (CGCG) is exceedingly rare. To the best of our knowledge just 57 cases of hybrid COF-CGCG have been reported worldwide. Here we report a case of hybrid COF-CGCG in a 31-year-old woman. a well-defined radiolucency in the premolar region of the mandible was seen. Surgical excision was performed, and histologic study shows fibro-cellular tissue containing giant cells, zones of mesenchymal cells proliferation, in a whorled pattern and, multiple cords and small nests of odontogen

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6

`Fomete, B., M. O. A. Samaila, R. Agbara, S. O. Ajike, and W. F. Foto. "Giant Aggressive Odontogenic Fibroma in a 15-month-old Female: Case Report and Review of Literature." West Africa Journal of Medicine 38, no. 12 (2021): 1238–41. http://dx.doi.org/10.55891/wajm.v38i12.54.

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Introduction: Odontogenic fibroma (OF) is a rare benign tumor of mesenchymal odontogenic tissue with variable global incidence. Two variants comprising extraosseous /peripheral (POF) and intraosseous /central (COF) have been identified based on the anatomical origin of the tumor. OF isslow growing, and often asymptomatic with characteristic radiographic appearance of a unilocular or multilocular cyst frequently associated with unerupted or displaced teeth while histologically, varying amount of inactive odontogenic epithelium embedded in a mature relatively dense collagenous stroma is diagnost

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7

Soolari, Ahmad, and Asghar Khan. "Central Odontogenic Fibroma of the Gingiva: A Case Report." Open Dentistry Journal 8, no. 1 (2015): 280–88. http://dx.doi.org/10.2174/1874210601408010280.

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In this paper, we present a case of an uncommon and slow-growing tumor known as a central odontogenic fibroma (COF). The patient in question is a 53-year-old African-American man who was referred for periodontal evaluation of asymptomatic space formation between the mandibular central incisors. Clinical and radiological evaluations disclosed tumor-like tissue expanding the alveolar ridge in the buccolingual dimension, along with thinning of the cortical plates. Surgical excision was performed, and the specimen was sent for histopathology, which later confirmed that the lesion was a COF. Period

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8

Khandekar, SP, and Alka Dive. "Central odontogenic fibroma." Journal of Oral and Maxillofacial Pathology 11, no. 2 (2007): 73. http://dx.doi.org/10.4103/0973-029x.37387.

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9

Venugopal, Sanjay, Satish Radhakrishna, Akshatha Raj, and Anshul Sawhney. "Central odontogenic fibroma." Journal of Indian Society of Periodontology 18, no. 2 (2014): 240. http://dx.doi.org/10.4103/0972-124x.131341.

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10

Watt-Smith, S. R., Nawal G. Ell-Labban, and Susan M. Tinkler. "Central odontogenic fibroma." International Journal of Oral and Maxillofacial Surgery 17, no. 2 (1988): 87–91. http://dx.doi.org/10.1016/s0901-5027(88)80156-5.

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11

Sepheriadou-Mavropoulou, Th, A. Patrikiou, and S. Sotiriadou. "Central odontogenic fibroma." International Journal of Oral Surgery 14, no. 6 (1985): 550–55. http://dx.doi.org/10.1016/s0300-9785(85)80064-8.

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12

de Matos, Felipe Rodrigues, Maiara de Moraes, Antonio Capistrano Neto, Márcia Cristina da Costa Miguel, and Éricka Janine Dantas da Silveira. "Central odontogenic fibroma." Annals of Diagnostic Pathology 15, no. 6 (2011): 481–84. http://dx.doi.org/10.1016/j.anndiagpath.2010.08.006.

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13

Bokhari, Kamran, Mustafa Abdel Bagi, Mutasim Al Nager, Sulphi Abdul Basheer, and Mohammed Abdullah M. Assiri. "Cemento-ossifying Fibroma Involving Mandible." International Journal of Experimental Dental Science 2, no. 2 (2013): 127–29. http://dx.doi.org/10.5005/jp-journals-10029-1054.

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ABSTRACT Cemento-ossifying fibroma (COF) is a rare neoplasm representing one of the benign fibro-osseous lesions of the jaw. This benign mesenchymal odontogenic lesion occurs more frequently in women than in men. Clinically, these tumors are slow growing with a centrifugal growth pattern. Radiologically, COFs present a number of patterns depending on the degree of mineralization. Histologically, these lesions are characterized by fibrous tissue with islands of bone or cementiform calcifications. We present a case of COF involving mandible in a 35-year-old male patient treated by excision. How

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14

Prasad, Bhange, Wankhede Shubhada, and Gavit Tejas. "Cemento-ossifying Fibroma." International Journal of Pharmaceutical and Clinical Research 15, no. 10 (2023): 203–5. https://doi.org/10.5281/zenodo.11246696.

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Cemento-ossifying fibromas are rare fibro-osseous benign neoplasms that affect the jaws. They are included in the group of mesodermal odontogenic tumors and commonly present as a progressively growing lesion that might attain enormous size with resultant deformity, if left untreated. A case of cemento-ossifying fibroma involving the left mandibular region of 10-year-old male patient. The clinical, radiographic, histologic features are presented and the various differential diagnosis are discussed. Cemento-ossifying fibroma (COF) is a distinct form of a benign fibro-osseous tumor, affecting pre

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15

Grégoire, Kwedi Karl Guy, and Diakite Youssouf. "Peripheral Odontogenic Fibroma: Case Report and Literature Review." EAS Journal of Dentistry and Oral Medicine 4, no. 3 (2022): 97–101. http://dx.doi.org/10.36349/easjdom.2022.v04i03.004.

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Odontogenic fibroma is a rare benign tumor of mature fibrous connective tissue, with varying amounts of inactive-appearing odontogenic epithelium, with or without evidence of calcification. There are two types ; central odontogenic fibroma and peripheral odontogenic fibroma. Peripheral odontogenic fibroma is a rare, non-encapsulated benign tumor of the oral mucosa often mistaken for a reactive lesion. Peripheral odontogenic fibroma is very often underdiagnosed or simply misdiagnosed, and therefore not much is known about this lesion. Through this work, we tried to bring out the sociodemographi

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16

Gardner, David G. "Central odontogenic fibroma current concepts." Journal of Oral Pathology and Medicine 25, no. 10 (1996): 556–61. http://dx.doi.org/10.1111/j.1600-0714.1996.tb01731.x.

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17

Hirshberg, Abraham, Dan Dayan, Isack Horowitz, and Mark M. Littner. "The simple central odontogenic fibroma." Journal of Cranio-Maxillofacial Surgery 15 (January 1987): 379–80. http://dx.doi.org/10.1016/s1010-5182(87)80088-4.

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18

Benson, K. "Central odontogenic fibroma current concepts." Journal of Oral and Maxillofacial Surgery 55, no. 6 (1997): 653–54. http://dx.doi.org/10.1016/s0278-2391(97)90514-0.

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19

Vincent, Steven D., Harold L. Hammond, Gary L. Ellis, and James P. Juhlin. "Central granular cell odontogenic fibroma." Oral Surgery, Oral Medicine, Oral Pathology 63, no. 6 (1987): 715–21. http://dx.doi.org/10.1016/0030-4220(87)90376-8.

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20

Allen, Carl M., Harold L. Hammond, and Paul G. Stimson. "Central odontogenic fibroma, WHO∗ type." Oral Surgery, Oral Medicine, Oral Pathology 73, no. 1 (1992): 62–66. http://dx.doi.org/10.1016/0030-4220(92)90156-k.

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21

Betancourt Carpio, M. I. J., J. R. Dopazo, H. Velez Gimon, et al. "Odontogenic central fibroma case report." International Journal of Oral and Maxillofacial Surgery 40, no. 10 (2011): 1183. http://dx.doi.org/10.1016/j.ijom.2011.07.531.

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22

Kim, Su-Wan, Jae-Seek You, Gyeong-Yun Kim, and Dong-Ho Shin. "Central odontogenic fibroma case report." Oral Biology Research 48, no. 1 (2024): 26–30. http://dx.doi.org/10.21851/obr.48.01.202403.26.

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23

Brademann, Goetz, Jochen A. Werner, Ute Jänig, Hubertus M. Mehdorn, and Heinrich Rudert. "Cemento-ossifying fibroma of the petromastoid region: case report and review of the literature." Journal of Laryngology & Otology 111, no. 2 (1997): 152–55. http://dx.doi.org/10.1017/s0022215100136709.

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AbstractThe cemento-ossifying fibroma (COF) is a mesodermal, non-odontogenic tumour of ectopic multipotential periodontal membrane blast cells. It is aggressive, locally destructive, and has a high recurrence rate. A case report of COF of the petromastoid region is presented. This location has not been described until now. Trauma may act as a trigger to sudden growth of the atopic periodontal tissue. Due to the aggressive behaviour of this tumour and its frequent recurrence radical surgery is needed.

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24

Monteiro, Luis Silva, Marco Martins, José Júlio Pacheco, et al. "Er:YAG Laser Assisted Treatment of Central Odontogenic Fibroma of the Mandible." Case Reports in Dentistry 2015 (2015): 1–6. http://dx.doi.org/10.1155/2015/230297.

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Central odontogenic fibroma is a very rare benign odontogenic tumour characterized by a fibrous mature stroma with variable strands or islands of inactive-looking odontogenic epithelium. Our aim is to report a case of a central odontogenic fibroma and describe the clinical usefulness of Er:YAG laser for the surgical treatment of this tumour. A 74-year-old woman presented with an expansive lesion located in a mandible with multilocular and mixed radiographic appearance. A conservative excision using Er:YAG laser was performed. Complete removal was obtained. There were no postoperative complicat

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25

Oueslati, Yassine, Raouaa Belkacem Chebil, Lamia Oualha, et al. "Central odontogenic fibroma of simple type: An original observation." SAGE Open Medical Case Reports 9 (January 2021): 2050313X2110124. http://dx.doi.org/10.1177/2050313x211012494.

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Central odontogenic fibroma is an uncommon, benign, slow-growing intraosseous mesenchymal odontogenic tumour. It presents a diagnostic dilemma to the clinician and the pathologist because its clinical and radiological features resemble other odontogenic and/or non-odontogenic tumours, and the differential diagnosis is based on histological examination. In this report, we describe our experience with a case of a 23-year-old female patient with central odontogenic fibroma of the mandible that was diagnosed as ‘simple type’. Highlighting a subtype that was dropped from the last World Health Organ

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26

Brannon, Robert B. "Central odontogenic fibroma, myxoma (odontogenic myxoma, fibromyxoma), and central odontogenic granular cell tumor." Oral and Maxillofacial Surgery Clinics of North America 16, no. 3 (2004): 359–74. http://dx.doi.org/10.1016/j.coms.2004.03.004.

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27

Veeravarmal, V., RNirmal Madhavan, MMohamed Nassar, and R. Amsaveni. "Central odontogenic fibroma of the maxilla." Journal of Oral and Maxillofacial Pathology 17, no. 2 (2013): 319. http://dx.doi.org/10.4103/0973-029x.119767.

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28

Harti, KarimaEl, Abdelilah Oujilal, and El Wady Wafaa. "Central odontogenic fibroma of the maxilla." Indian Journal of Dentistry 6, no. 4 (2015): 217. http://dx.doi.org/10.4103/0975-962x.165051.

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29

Chhabra, V., and A. Chhabra. "Central odontogenic fibroma of the mandible." Contemporary Clinical Dentistry 3, no. 2 (2012): 230. http://dx.doi.org/10.4103/0976-237x.96845.

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30

Nah, Kyung-Soo. "Central odontogenic fibroma: a case report." Imaging Science in Dentistry 41, no. 2 (2011): 85. http://dx.doi.org/10.5624/isd.2011.41.2.85.

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31

Sakamoto, Ichiro, Akemi Gunji, and Ken Omura. "Central Odontogenic Fibroma of the Maxilla." Asian Journal of Oral and Maxillofacial Surgery 15, no. 4 (2003): 288–91. http://dx.doi.org/10.1016/s0915-6992(03)80011-0.

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32

Reichart, Peter A., Hans Peter Philipsen, Alexander Moegelin, and Uwe Thalmann. "Central odontogenic fibroma, granular cell variant." Oral Oncology Extra 42, no. 1 (2006): 5–9. http://dx.doi.org/10.1016/j.ooe.2005.05.007.

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33

Bodner, L. "Central odontogenic fibroma. A case report." International Journal of Oral and Maxillofacial Surgery 22, no. 3 (1993): 166–67. http://dx.doi.org/10.1016/s0901-5027(05)80244-9.

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34

DE ALENCAR JUNIOR, EVANDRO FARIAS, LUIZ ARTHUR BARBOSA DA SILVA, ANTONIO DIONÍZIO DE ALBUQUERQUE NETO, et al. "Central Odontogenic Fibroma: A Case Report." Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology 120, no. 2 (2015): e25. http://dx.doi.org/10.1016/j.oooo.2015.02.075.

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35

De Noronha, Mariana Saturnino, Jefferson Da Cruz Silva, Maria Cássia Ferreira De Aguiar, and Ricardo Alves Mesquita. "Central Odontogenic Fibroma: a Case Report." Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology 126, no. 3 (2018): e87. http://dx.doi.org/10.1016/j.oooo.2018.02.267.

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36

Kaffe, Israel, and Amos Buchner. "Radiologic features of central odontogenic fibroma." Oral Surgery, Oral Medicine, Oral Pathology 78, no. 6 (1994): 811–18. http://dx.doi.org/10.1016/0030-4220(94)90101-5.

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37

Costa, Amanda Maciel, Elena Riet Correa Rivero, Aline Hsiao Bona, Iara Beatriz Arruda Machado, Liliane Janete Grando, and Túlio Del Conte Valcanaia. "Central odontogenic fibroma: a case report." Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology 139, no. 5 (2025): e61. https://doi.org/10.1016/j.oooo.2025.01.314.

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38

Lotay, Harinder S., John Kalmar, and Karel DeLeeuw. "Central odontogenic fibroma with features of central granular cell odontogenic tumor." Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology 109, no. 2 (2010): e63-e66. http://dx.doi.org/10.1016/j.tripleo.2009.10.018.

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39

Koszowski, Rafał, Joanna Śmieszek-Wilczewska, and Katarzyna Stęplewska. "Odontogenic fibroma — a case report." Open Medicine 9, no. 2 (2014): 250–53. http://dx.doi.org/10.2478/s11536-012-0137-2.

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AbstractIThe present study outlines the case of a 30-year-old patient with central odontogenic fibroma. The tumour developed in the alveolar process of the maxilla in the area of 13–15. The study describes the clinical symptoms, the radiological image, treatment method and histopathological image of the tumour. The study also presents a one-year period of post-surgical observation.

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40

Bordoloi, Bharadwaj, Aanchal Tandon, Safia Siddiqui, and Rohit Jaiswal. "Central odontogenic fibroma with unusual presenting symptoms." Cancer Translational Medicine 4, no. 6 (2018): 167. http://dx.doi.org/10.4103/ctm.ctm_29_18.

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41

Alawi, F., and P. Quinn. "Atypical central odontogenic fibroma recurring as ameloblastoma." Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology 98, no. 2 (2004): 201. http://dx.doi.org/10.1016/j.tripleo.2004.06.030.

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42

MOTTA, ANA CAROLINA FRAGOSO, MATHEUS SANGALLI FILIPPIN, MARCELO RODRIGUES AZENHA, et al. "Amyloid/Dendritic Cell Associated Central Odontogenic Fibroma." Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology 120, no. 2 (2015): e77. http://dx.doi.org/10.1016/j.oooo.2015.02.340.

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43

Sachdeva, SureshK, Pradhuman Verma, Dinesh Verma, and KanikaGupta Verma. "Recurrent central odontogenic fibroma: An uncommon clinical presentation." Saudi Surgical Journal 2, no. 1 (2014): 22. http://dx.doi.org/10.4103/2320-3846.132900.

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44

Mendes, Emanuel, Taiana Campos Leite, Bruno Augusto Benevenuto De Andrade, et al. "Central Odontogenic Fibroma: Report of Three New Cases." Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology 126, no. 3 (2018): e86. http://dx.doi.org/10.1016/j.oooo.2018.02.263.

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45

Ide, Fumio, Hideaki Sakashita, and Kaoru Kusama. "Ameloblastomatoid, central odontogenic fibroma: an epithelium-rich variant." Journal of Oral Pathology & Medicine 31, no. 10 (2002): 612–14. http://dx.doi.org/10.1034/j.1600-0714.2002.00041.x.

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46

Flores-Hidalgo, A., V. A. Murrah, and T. Biggerstaff. "HYBRID CENTRAL ODONTOGENIC FIBROMA AND CENTRAL GIANT CELL GRANULOMA LESION." Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology 122, no. 5 (2016): e173. http://dx.doi.org/10.1016/j.oooo.2016.06.079.

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47

Panda, Swagatika, Saswati Sidharatha, and Neeta Mohanty. "Central Odontogenic Fibroma Coexisting with Inflammatory Odontogenic Cyst: The Second Case Report." Indian Journal of Public Health Research & Development 10, no. 11 (2019): 1183. http://dx.doi.org/10.5958/0976-5506.2019.03677.5.

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48

Seok, In-Young, Byung-Ju Park, Suk Ja Yoon, Young Kim, Byung-Cheol Kang, and Jae-seo Lee. "Case Report of Central Odontogenic Fibroma in the Maxilla." Korean Journal of Oral and Maxillofacial Pathology 44, no. 5 (2020): 147–51. http://dx.doi.org/10.17779/kaomp.2020.44.5.003.

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49

Koutlas, Dr Ioannis G., Dr Katia Julissa Ponce, Dr Rima-Marie Wazen, and Dr Antonio Nanci. "Tubuloductal/syringoid variant of central odontogenic fibroma with amyloid?" Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology 133, no. 5 (2022): e139. http://dx.doi.org/10.1016/j.oooo.2021.12.053.

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50

Daskala, Ioanna, Demos Kalyvas, Markos Kolokoudias, Dimitris Vlachodimitropoulos, and Constatinos Alexandridis. "Central odontogenic fibroma of the mandible: a case report." Journal of Oral Science 51, no. 3 (2009): 457–61. http://dx.doi.org/10.2334/josnusd.51.457.

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