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Journal articles on the topic 'Centriole elimination'

Author: Grafiati
Published: 14 March 2023
Last updated: 31 July 2025

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1

Pimenta-Marques, A., I. Bento, C. A. M. Lopes, P. Duarte, S. C. Jana, and M. Bettencourt-Dias. "A mechanism for the elimination of the female gamete centrosome inDrosophila melanogaster." Science 353, no. 6294 (2016): aaf4866. http://dx.doi.org/10.1126/science.aaf4866.

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An important feature of fertilization is the asymmetric inheritance of centrioles. In most species it is the sperm that contributes the initial centriole, which builds the first centrosome that is essential for early development. However, given that centrioles are thought to be exceptionally stable structures, the mechanism behind centriole disappearance in the female germ line remains elusive and paradoxical. We elucidated a program for centriole maintenance in fruit flies, led by Polo kinase and the pericentriolar matrix (PCM): The PCM is down-regulated in the female germ line during oogenes
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2

Borrego-Pinto, Joana, Kálmán Somogyi, Matthia A. Karreman, et al. "Distinct mechanisms eliminate mother and daughter centrioles in meiosis of starfish oocytes." Journal of Cell Biology 212, no. 7 (2016): 815–27. http://dx.doi.org/10.1083/jcb.201510083.

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Centriole elimination is an essential process that occurs in female meiosis of metazoa to reset centriole number in the zygote at fertilization. How centrioles are eliminated remains poorly understood. Here we visualize the entire elimination process live in starfish oocytes. Using specific fluorescent markers, we demonstrate that the two older, mother centrioles are selectively removed from the oocyte by extrusion into polar bodies. We show that this requires specific positioning of the second meiotic spindle, achieved by dynein-driven transport, and anchorage of the mother centriole to the p
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3

Bonente, Denise, Giuliano Callaini, and Maria Giovanna Riparbelli. "Inactivation and Elimination of Centrioles During Development in the Genus Drosophila: Current Insights and Open Questions." Cells 14, no. 12 (2025): 865. https://doi.org/10.3390/cells14120865.

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Centrioles are remarkably stable organelles that play a main role in the assembly of centrosomes and ciliary structures. However, there are several differentiated tissues that must eliminate their centrioles to avoid centrosome formation and improper cell proliferation. Therefore, centriole elimination represents an important process in many organisms to ensure successful cell differentiation and maintenance of tissue homeostasis. In this review, we analyzed centriole inactivation and elimination in various Drosophila cell types in relation to the dynamics of the pericentriolar material.
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4

Fuge, H. "Unorthodox male meiosis in Trichosia pubescens (Sciaridae). Chromosome elimination involves polar organelle degeneration and monocentric spindles in first and second division." Journal of Cell Science 107, no. 1 (1994): 299–312. http://dx.doi.org/10.1242/jcs.107.1.299.

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Male meiosis in Trichosia pubescens (Sciaridae) was investigated by means of serial section electron microscopy and immunofluorescence light microscopy. From earlier studies of another sciarid fly, Sciara coprophila (Phillips (1967) J. Cell. Biol. 33, 73–92), it is known that the spindle poles in sciarid spermatogonia are characterized by pairs of ‘giant centrioles’, ring-shaped organelles composed of large numbers of singlet microtubules. In the present study spermatocytes in early prophase of Trichosia were found to possess single giant centrioles at opposite sides of the nucleus. The obviou
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5

Mikeladze-Dvali, T., L. von Tobel, P. Strnad, et al. "Analysis of centriole elimination during C. elegans oogenesis." Development 139, no. 9 (2012): 1670–79. http://dx.doi.org/10.1242/dev.075440.

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6

Wang, Chia-Yih, Yung-Hsin Kao, Pao-Yen Lai, Wei-Yi Chen, and Bon-chu Chung. "Steroidogenic Factor 1 (NR5A1) Maintains Centrosome Homeostasis in Steroidogenic Cells by Restricting Centrosomal DNA-Dependent Protein Kinase Activation." Molecular and Cellular Biology 33, no. 3 (2012): 476–84. http://dx.doi.org/10.1128/mcb.01064-12.

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ABSTRACTSteroidogenic factor 1 (SF-1 or NR5A1) is a nuclear receptor that controls adrenogenital cell growth and differentiation. Adrenogenital primordial cells fromSF-1knockout mice die of apoptosis, but the mechanism by which SF-1 regulates cell survival is not entirely clear. Besides functioning in the nucleus, SF-1 also resides in the centrosome and controls centrosome homeostasis. Here, we show that SF-1 restricts centrosome overduplication by inhibiting aberrant activation of DNA-dependent protein kinase (DNA-PK) in the centrosome. SF-1 was found to be associated with Ku70/Ku80 only in t
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7

Samanta, Minu, Daivd Groff, Isabel Soria-Bretones, et al. "Abstract 1201: The PLK4 inhibitor RP-1664 drives centriole modulation and single agent tumor regressions in preclinical neuroblastoma models." Cancer Research 85, no. 8_Supplement_1 (2025): 1201. https://doi.org/10.1158/1538-7445.am2025-1201.

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Abstract Background: Increased expression of TRIM37, an E3 ligase encoded at chromosome 17q23, causes dysfunction of the pericentriolar material and creates a synthetic lethal vulnerability with PLK4 inhibition in cancer cells (Yeow, Nature 2020 and Meitinger, Nature 2020). High-risk neuroblastoma (HRNB) is a childhood cancer that is typically, widely metastatic at diagnosis and is lethal in over 50% of patients despite intensive multimodal therapy. Copy number gain of 17q is a common somatic aberration across human cancers but is a universal feature of HRNB. Here we tested the hypothesis that
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8

Schoborg, Todd A., and Nasser M. Rusan. "Taking Centrioles to the Elimination Round." Developmental Cell 38, no. 1 (2016): 10–12. http://dx.doi.org/10.1016/j.devcel.2016.06.027.

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9

Ryniawec, John M., Gregory C. Rogers, and Anne E. Cress. "Abstract A016: Mechanism of hypoxia-induced centrosome loss in early prostate cancer." Cancer Research 83, no. 11_Supplement (2023): A016. http://dx.doi.org/10.1158/1538-7445.prca2023-a016.

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Abstract PURPOSE: We aim to understand cellular and microenvironmental determinants of chromosomal instability in prostate cancer and use these findings as prognostic biomarkers portending aggressive disease. Disease transitions during prostate cancer progression are accompanied by bursts of chromosomal instability (CIN), including chromosomal translocations, oncogene amplifications, and chromothripsis. While high CIN correlates with most metrics of aggressive disease, we lack a mechanistic understanding of how CIN originates in prostate cancer. Recently, we discovered that low Gleason score,
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10

Kim, Dae Young, and Richard Roy. "Cell cycle regulators control centrosome elimination during oogenesis in Caenorhabditis elegans." Journal of Cell Biology 174, no. 6 (2006): 751–57. http://dx.doi.org/10.1083/jcb.200512160.

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In many animals, the bipolar spindle of the first zygotic division is established after the contribution of centrioles by the sperm at fertilization. To avoid the formation of a multipolar spindle in the zygote, centrosomes are eliminated during oogenesis in most organisms, although the mechanism of this selective elimination is poorly understood. We show that cki-2, a Caenorhabditis elegans cyclin-dependent kinase (Cdk) inhibitor, is required for their appropriate elimination during oogenesis. In the absence of cki-2, embryos have supernumerary centrosomes and form multipolar spindles that re
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11

Pecio, Anna, John R. Burns, and Stanley H. Weitzman. "Comparison of spermiogenesis in the externally fertilizing Hemigrammus erythrozonus and the inseminating Corynopoma riisei (Teleostei: Characiformes: Characidae)." Neotropical Ichthyology 5, no. 4 (2007): 457–70. http://dx.doi.org/10.1590/s1679-62252007000400005.

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Spermiogenesis and sperm ultrastructure were analyzed in two species of characids with different modes of fertilization: externally fertilizing Hemigrammus erythrozonus and inseminating Corynopoma riisei. Spermiogenesis in H. erythrozonus is characterized by lateral development of the flagellum, nuclear rotation, formation of a shallow nuclear fossa, condensation of the chromatin by elimination of the electron-lucent area from the peripheral region of the nucleus, and renewal of the nuclear membrane. Multilammelated membrane and multivesicular bodies were also observed during elimination of th
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12

Valbuena, Galder, Juan Francisco Madrid, María Martínez de Ubago, et al. "N-Glycans in Xenopus laevis testis characterised by lectin histochemistry." Reproduction, Fertility and Development 28, no. 3 (2016): 337. http://dx.doi.org/10.1071/rd14077.

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Analysis of glycan chains of glycoconjugates is difficult because of their considerable variety. Despite this, several functional roles for these glycans have been reported. N-Glycans are oligosaccharides linked to asparagine residues of proteins. They are synthesised in the endoplasmic reticulum (ER) in a unique way, and later modified in both the ER and Golgi apparatus, developing different oligosaccharide chains. An essential role for complex N-glycans in mammalian spermatogenesis has been reported. The aim of the present study was to analyse the N-glycans of the Xenopus laevis testis by me
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13

Pierron, Marie, Alexander Woglar, Coralie Busso, et al. "Centriole elimination during Caenorhabditis elegans oogenesis initiates with loss of the central tube protein SAS‐1." EMBO Journal, November 21, 2023. http://dx.doi.org/10.15252/embj.2023115076.

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AbstractIn most metazoans, centrioles are lost during oogenesis, ensuring that the zygote is endowed with the correct number of two centrioles, which are paternally contributed. How centriole architecture is dismantled during oogenesis is not understood. Here, we analyze with unprecedent detail the ultrastructural and molecular changes during oogenesis centriole elimination in Caenorhabditis elegans. Centriole elimination begins with loss of the so‐called central tube and organelle widening, followed by microtubule disassembly. The resulting cluster of centriolar proteins then disappears gradu
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14

Kalbfuss, Nils, and Pierre Gönczy. "Towards understanding centriole elimination." Open Biology 13, no. 11 (2023). http://dx.doi.org/10.1098/rsob.230222.

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Centrioles are microtubule-based structures crucial for forming flagella, cilia and centrosomes. Through these roles, centrioles are critical notably for proper cell motility, signalling and division. Recent years have advanced significantly our understanding of the mechanisms governing centriole assembly and architecture. Although centrioles are typically very stable organelles, persisting over many cell cycles, they can also be eliminated in some cases. Here, we review instances of centriole elimination in a range of species and cell types. Moreover, we discuss potential mechanisms that enab
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15

Tkemaladze, Jaba. "Centriole Elimination: A Mechanism for Resetting Entropy in the Cell." February 15, 2025. https://doi.org/10.5281/zenodo.15053431.

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Centrioles are highly conserved organelles within the eukaryotic domain of life, playing an indispensable role in microtubule organization, cellular differentiation, and the formation of cilia and flagella. However, in the processes of oogenesis and spermatogenesis in certain organisms, centrioles undergo elimination, thereby preventing the transmission of either young or aged centrioles to the zygote, depending on the specific system of asymmetric division. The removal of centrioles in gametes can be interpreted as a mechanism of resetting cellular entropy and restoring totipotency, which is
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16

Kalbfuss, Nils, and Pierre Gönczy. "Extensive programmed centriole elimination unveiled in C. elegans embryos." Science Advances 9, no. 22 (2023). http://dx.doi.org/10.1126/sciadv.adg8682.

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Centrioles are critical for fundamental cellular processes, including signaling, motility, and division. The extent to which centrioles are present after cell cycle exit in a developing organism is not known. The stereotypical lineage of Caenorhabditis elegans makes it uniquely well-suited to investigate this question. Using notably lattice light-sheet microscopy, correlative light electron microscopy, and lineage assignment, we found that ~88% of cells lose centrioles during embryogenesis. Our analysis reveals that centriole elimination is stereotyped, occurring invariably at a given time in
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17

Qi, Feifei, Shanshan Yin, Xiangrui Yang, et al. "Dynamic SAS-6 phosphorylation aids centrosome duplication and elimination in C. elegans oogenesis." EMBO Reports, May 23, 2025. https://doi.org/10.1038/s44319-025-00485-7.

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Abstract In most metazoans, centrosome elimination during oogenesis ensures accurate centriole inheritance in the zygote, yet the molecular mechanisms remain poorly understood. Here, we reveal a critical role for controlled SAS-6 phosphorylation in centrosome dynamics during oogenesis. Centrioles disassemble during late meiotic prophase, while the cartwheel protein SAS-6 exhibits dynamic behavior in early meiotic prophase. Purified SAS-6 undergoes phase separation in vitro, and overexpressed SAS-6 forms droplets in cells. Mass spectrometry and kinase assays reveal that SAS-6 is phosphorylated
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18

Woglar, Alexander, Coralie Busso, Gabriela Garcia-Rodriguez, et al. "Mechanisms of axoneme and centriole elimination in Naegleria gruberi." EMBO Reports, December 2, 2024. https://doi.org/10.1038/s44319-024-00329-w.

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AbstractThe early branching eukaryote Naegleria gruberi can transform transiently from an amoeboid life form lacking centrioles and flagella to a flagellate life form where these elements are present, followed by reversion to the amoeboid state. The mechanisms imparting elimination of axonemes and centrioles during this reversion process are not known. Here, we uncover that flagella primarily fold onto the cell surface and fuse within milliseconds with the plasma membrane. Once internalized, axonemes are severed by Spastin into similarly-sized fragments that are then enclosed by membranes, bef
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19

Tkemaladze, Jaba. "Elimination of centrioles." GEORGIAN SCIENTISTS, November 19, 2024. http://dx.doi.org/10.52340/gs.2024.06.04.25.

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20

Tkemaladze, Jaba. "Concept to The Eternal Youth." January 18, 2025. https://doi.org/10.5281/zenodo.15048562.

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Eternal youth, a concept once relegated to the realm of fantasy, is becoming a reality through advancements in regenerative medicine and cellular technologies. Central to this breakthrough is the replacement of aged adult stem cells, which lose their regenerative potential and accumulate old centrioles and mutations, with rejuvenated, functional stem cells. Aged stem cells divide slowly, contributing to tissue dysfunction, and their targeted removal is critical for restoring youthful cellular environments. Rejuvenated stem cells are induced by reprogramming a patient’s somatic cells, cre
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