Relevant bibliographies by topics / Cephradine

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  2. Dissertations / Theses
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  5. Conference papers

Academic literature on the topic 'Cephradine'

Author: Grafiati
Published: 4 June 2021
Last updated: 1 February 2022

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Journal articles on the topic "Cephradine"

1

Aboubakr, Mohamed, and Mohamed Elbadawy. "Bioavailability, pharmacokinetics and tissue residues of cephradine (Atocef Forte®) in healthy and colisepticemic broiler chickens." International Journal of Pharmacology and Toxicology 5, no. 1 (April 22, 2017): 57. http://dx.doi.org/10.14419/ijpt.v5i1.7428.

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The pharmacokinetics (after single intravenous and oral dose) and tissue residues (orally and daily for five days) of cephradine (20 mg/kg b.wt.) were investigated in healthy and experimentally E.coli infected broiler chickens. Following single intravenous injection to healthy chickens, cephradine obeyed a two compartments open model and the elimination half-life (t1/2β), volume of distribution (Vdss) and total body clearance (CLtot) of cephradine were 2.93 h, 321.5 ml/kg and 0.08 L/h/kg, respectively. Following single oral administration of cephradine to healthy chickens, the peak serum concentration (Cmax) of it was 26.7 µg/mL and achieved (Tmax) at 2.41 h. The oral bioavailability of cephradine was 87.7%. Cephradine was assayed in kidney, liver, heart, gizzard, spleen, breast muscle, thigh muscle and skin after 24, 48, 72, 96 and 120 h after last dose. On conclusion, cephradine is a good choice for treatment of colisepticemia in chickens due to its higher oral bioavailability and distribution.
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2

Azad, Md Abul Kalam, Zaheedur Rahman, and Md Nurul Amin. "A study on Antimicrobial Resistance: recent trend in Armed Forces of Bangladesh." Journal of Armed Forces Medical College, Bangladesh 9, no. 2 (February 2, 2015): 03–09. http://dx.doi.org/10.3329/jafmc.v9i2.21818.

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Introduction: Antimicrobial resistance has increased dramatically & to be a serious threat to the treatment of infectious disease on a global basis. As a result morbidity, mortality & economic burden of infections with multiple drug resistance organisms for which there are no effective therapies. Over use of antibiotics in developed nations of paradoxically both misuses of under use in developing nations have contributed to the burden. Objectives: The objective of the study is to identify common microorganisms and to assess their sensitivity to three selected antibiotics. Methods: This observational study was conducted in Armed Forces Institute of Pathology (AFIP), Dhaka, Bangladesh among samples of urine, blood, pus, sputum and throat swab. All of the samples of urine (173), Blood (31), pus (63), sputum (28) and throat swab (14) were tested for culture and sensitivity at AFIP over a period from January 2012 to February 2013. Selected antibiotics were ciprofloxacin, cephradine and cefixime. Results: Commonest organisms found in different samples were Escherichia coli in urine (57.8%), Salmonella typhi in blood (54.8%), Staphylococcus aureus in pus (42.9%), klebsiella in sputum (67.9%) and Streptococcus pyogens in throat swab 03 JAFMC Bangladesh. Vol 9, No 2 (December) 2013 (78.6%). In urine samples, microorganisms were found resistant to cephradine in 95% cases but sensitive to cefixime in 30.4% cases. Microorganisms in blood samples were sensitive to cefixime in 83.3% and Ciprofloxacin in 80.6% cases. Ciprofloxacin, cephradin and cefixime all three antibiotics encountered resistance in 63.5%, 82.5% and 75.8% samples of pus respectively. Among sputum samples organisms were sensitive to ciprofloxacin in 71.4% and cefixime in 64.3% cases whereas resistant to cephradin in 92.9% cases. In organisms of throat swab Cephradine Showed sensitivity in 71.4% cases but cefixime encountered resistance in 57.1% cases. Conclusion: The study reveals an alarming picture of antimicrobial resistance pattern in Bangladesh Armed Forces. DOI: http://dx.doi.org/10.3329/jafmc.v9i2.21818 Journal of Armed Forces Medical College Bangladesh Vol.9(2) 2013
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3

Chohan, Zahid H., and Maimoon F. Jaffery. "Synthesis, Characterization and Biological Evaluation of Co(II), Cu(II), Ni(II) and Zn(II) Complexes With Cephradine." Metal-Based Drugs 7, no. 5 (January 1, 2000): 265–69. http://dx.doi.org/10.1155/mbd.2000.265.

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Some Co(II), Cu(II), Ni(II) and Zn(II) complexes of antibacterial drug cephradine have been prepared and characterized by their physical, spectral and analytical data. Cephradine acts as bidentate and the complexes have compositions, [M(L)2X2] where [M = Co(II), Ni(II) and Zn(II), L = cephradine and X = Cl2] showing octahedral geometry, and [M(L)2] where [M = Cu(II), L = cephradine] showing square planar geometry. In order to evaluate the effect of metal ions upon chelation, eephradine and its complexes have been screened for their antibacterial activity against bacterial strains, Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa.
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4

Sultan, M. Z., M. A. Mazid, and M. A. Rashid. "Stability Assessment of Cephradine Suspension Formulated in Bangladesh." Journal of Scientific Research 3, no. 2 (April 28, 2011): 383–91. http://dx.doi.org/10.3329/jsr.v3i2.7024.

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Cephradine, one of the commonly used and widely prescribed antibiotics in Bangladesh, is usually formulated in the dosage forms of capsule, dry suspension and IV injection. The dry-suspension is instructed to re-disperse in pre-boiled cooled water before use. A reversed phase high performance liquid chromatographic method (HPLC) has been developed for determination of cephradine in pharmaceutical preparation. To study the stability of cephradine suspension formulated by Bangladeshi manufacturers in aqueous medium and buffer of different pHs at room temperature, a simple and rapid chromatographic method was developed using acetonitrile and monobasic sodium phosphate buffer as mobile phase in the ratio of 15:85 (v/v) over C-8 bonded silica at ambient temperature using a flow rate of 1.0 mL/min. The study revealed that the potency of cephradine suspension was almost stable at room temperature up to 13 days in aqueous medium at pH between 4 and 5.Keywords: Cephradine; Suspension; HPLC; Potency; pH.© 2011 JSR Publications. ISSN: 2070-0237 (Print); 2070-0245 (Online). All rights reserved.doi:10.3329/jsr.v3i2.7024 J. Sci. Res. 3 (2), 383-391 (2011)
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5

Sohn, Young Taek, and Sun Hee Park. "Crystal form of cephradine." Archives of Pharmacal Research 29, no. 2 (February 2006): 178–82. http://dx.doi.org/10.1007/bf02974281.

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6

Farag, Shawky A. "Simultaneous Liquid Chromatographic Analysis of the β-Lactam Antibiotics Cefazolin, Cefadroxil, Cephalexin, Ampicillin, and Cephradine in Solution." Journal of AOAC INTERNATIONAL 81, no. 2 (March 1, 1998): 381–85. http://dx.doi.org/10.1093/jaoac/81.2.381.

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abstract A liquid chromatographic method was developed for the determination of nanogram quantities of 5 broad-spectrum structurally related β-lactam antibiotics (cefazolin, cefadroxil, cephalexin, cephradine, and ampicillin) in solution. The method uses a C18 reversed-phase column, UV absorption (240 nm) detection, and an aqueous mobile phase containing isopropyl alcohol and acetic acid. Relative resolution between the antibiotic peaks ranged from 1.7 to 5.9 for all peaks. Chromatographic retention times were 2.97, 3.92, 4.57, 5.37, and 6.56 min for cefazolin, cefadroxil, cephalexin, ampicillin, and cephradine, respectively. Accuracy, precision, linearity, and long term analytical reproducibility were determined by statistical analysis. Use of the proposed method to evaluate the degradation of cephradine solutions stored at room temperature illustrated its potential as a stability-indicating assay.
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7

Elkomy, Ashraf, Mohamed Aboubakr, Faten Elsayed, Elsayed Emam, and Mohammed Kassem. "Immunological status in broiler chickens vaccinated with newcastle vaccine and treated with cephradine." International Journal of Pharmacology and Toxicology 7, no. 2 (July 22, 2019): 22. http://dx.doi.org/10.14419/ijpt.v7i2.29194.

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The objective of this study is to clarify the effect of cephradine on cellular and humeral immune responses in broiler chickens. One hundred one-day-old Hubbard broiler chicks were divided into four equal groups (25 chicks in each). 1st group healthy broiler chickens non-vaccinated non medicated (control group), 2nd healthy broilers vaccinated with Newcastle vaccine only, 3rd group healthy broilers received 20 mg cephradine in drinking water daily for 5 consecutive days and 4th group healthy broilers vaccinated and received 20 mg/kg b.wt cephradine daily for 5 consecutive days. At 1st, 10th and 20th day post administration, blood samples were collected for determination total and differential leucocytic count, phagocytic activity, index, killing percentage and HI titer. Vaccinated broilers by Newcastle disease virus vaccine only, showed insignificant increase in leukocytic count, lymphocyte, heterophils, nitric oxide, lysozyme activity, total protein, total, γ globulin and HI titers at 1st day post vaccination. Beside significant increase at 10th and 20th day post vaccination coupled with insignificant increase in eosinophils, basophils, monocyte, phagocytic activity, phagocytic index, killing %, albumin and α globulin and non-significant decrease in serum β globulin and A/G ratio allover experimental periods post vaccination. Broilers received cephradine and/or vaccinated with Newcastle vaccineeither alone or together, showed insignificant increase in leukocyte, heterophils, lymphocyte, eosinophils, basophils, monocyte, nitric oxide, lysozyme activity, total protein, albumin, total, α, β, γ globulin, A/G ratio throughout experimental period post vaccination. Beside significant decrease in phagocytosis, phagocytic index and killing % at 1st day and insignificant decrease at 10th & 20th day post vaccination coupled with significant decrease in HI titers at 1st day post administration and insignificant decrease at 10th & 20th day post vaccination. It was concluded that vaccination by Newcastle disease virus vaccine induced immune-stimulant but cephradine provoked a remarkable immunosuppressive effect in broiler chickens. Therefore, vaccination not recommended during treatment by cephradine.
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8

Middlehurst, R. J., J. Pedlar, G. R. Barker, and J. P. Rood. "Cephradine penetration of mandibular bone." Journal of Oral and Maxillofacial Surgery 47, no. 7 (July 1989): 672–73. http://dx.doi.org/10.1016/s0278-2391(89)80003-5.

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9

Cai, Wei-Ping, Yao-Guo Ouyang, Xue-Yuan Lin, and Jin-Gou Xu. "Photochemical Fluorimetric Determination of Cephradine." Analytical Letters 31, no. 3 (February 1998): 439–50. http://dx.doi.org/10.1080/00032719808001850.

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10

Middlehurst, R. J., and J. P. Rood. "Cephradine (Velosef) penetration of mandibular bone." International Journal of Oral and Maxillofacial Surgery 19, no. 2 (April 1990): 120–21. http://dx.doi.org/10.1016/s0901-5027(05)80208-5.

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Dissertations / Theses on the topic "Cephradine"

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洪瑞泰. "Bioavailability Studies of Cephradine." Thesis, 1998. http://ndltd.ncl.edu.tw/handle/64419040115921620639.

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碩士
中國醫藥學院
藥物化學研究所
86
Cephradine is a cephalosporin antibiotics active against a broad spectrum of gram-positive and gram-negative bacteria by inhibiting the synthesis of bacterial cell wall. Cephradine is the only cephalosprine that can be administrated via oral and injection. Cephradine is stable in acid solution, well absorbed via oral and excreted unchanged in the urine. 　　Two quantitative methods are adopted in this study-bioassay and HPLC to quantify the concentration of cephradine in plasma for the 12 subjects in a bioequivalency test after dosing cephradine preparations-Velosef and Sephros capsules.The results of blood samples quantified by two said analysis methods reveal no difference in the two quantitative methods by pair-t test. From the mean pharmacokinetic parameters of each subject, we found the mean serum half-life is around 0.78 hour, clearance is around 20L/hr, distributive volume is 35.5L. No variety among the pharmacokinetic parameters for each subject after statistical by pair-t test. Besides, no variety among the pharmacokinectic parameters treatment with ANOVA procedure. The result of the 90% confidence intervals by two-one sided test design is between 0.8-1.2, it reveals that Velosef an Sephros are bioequivalent. 　　Two guantitative method used in this bioequivalent and bioavailability study are validated to bear acceptable precision and accuracy. 　　From the results of this study, we can find there is some difference of cephradine pharmacokinetic characters between Chinese and foreigners, that is the clearance rate, distribution volume of cephradine is higher in Chinese than in foreigner.
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Books on the topic "Cephradine"

1

Fleming, D. H. The influence of various factors on the absorption, disposition and elimination of two cephalosporin antibiotics: Cefaclor and cephradine. Birmingham: University of Birmingham, 1986.

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2

A, Percival, Woods P, and E.R. Squibb & Sons., eds. Cephradine 12 years on--a routine antibiotic for therapy and prophylaxis. London: Royal Society of Medicine, 1985.

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Book chapters on the topic "Cephradine"

1

Boeschoten, E. W., P. J. Rietra, R. T. Krediet, M. J. Visser, and L. Arisz. "No Difference Between Oral and Intraperitoneal Treatment of CAPD Peritonitis with Cephradine." In Frontiers in Peritoneal Dialysis, 625–29. Berlin, Heidelberg: Springer Berlin Heidelberg, 1986. http://dx.doi.org/10.1007/978-3-662-11784-2_121.

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2

Castle, Sharon S. "Cephradine." In xPharm: The Comprehensive Pharmacology Reference, 1–5. Elsevier, 2007. http://dx.doi.org/10.1016/b978-008055232-3.61419-9.

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3

Paterson, David, and Marta Gomez. "Cephadroxil, Cephaloridine, Cephacetrile, Cephapirin, Cephradine and Other Rarely Used First-Generation Cephalosporins." In Kucers' The Use of Antibiotics Sixth Edition, 275–79. CRC Press, 2010. http://dx.doi.org/10.1201/b13787-25.

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Conference papers on the topic "Cephradine"

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Jiang, Qingfeng, Yibin Ying, Jianping Wang, Zunzhong Ye, and Yanbin Li. "Detection of cephradine through the electrochemical study of the degradation product of cephradine." In Optics East 2005, edited by Arthur J. SedlacekIII, Steven D. Christesen, Roger J. Combs, and Tuan Vo-Dinh. SPIE, 2005. http://dx.doi.org/10.1117/12.630648.

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