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1

Høilund-Carlsen, Poul F., Mona-Elisabeth Revheim, Tommaso Costa, et al. "FDG-PET versus Amyloid-PET Imaging for Diagnosis and Response Evaluation in Alzheimer’s Disease: Benefits and Pitfalls." Diagnostics 13, no. 13 (2023): 2254. http://dx.doi.org/10.3390/diagnostics13132254.

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In June 2021, the US Federal Drug and Food Administration (FDA) granted accelerated approval for the antibody aducanumab and, in January 2023, also for the antibody lecanemab, based on a perceived drug-induced removal of cerebral amyloid-beta as assessed by amyloid-PET and, in the case of lecanemab, also a presumption of limited clinical efficacy. Approval of the antibody donanemab is awaiting further data. However, published trial data indicate few, small and uncertain clinical benefits, below what is considered “clinically meaningful” and similar to the effect of conventional medication. Fur
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Reale, Giuseppe, Augusto Fusco, Fabrizio Cocciolillo, et al. "Live Effects of Anodal and Cathodal Transcranial Direct Current Stimulation on Brain Metabolism in a Patient with Typical Hemorrhagic Stroke: A Case Study." Brain Sciences 15, no. 6 (2025): 594. https://doi.org/10.3390/brainsci15060594.

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In this study, we aimed to assess the effects of transcranial direct current stimulation (tDCS) stimulation on brain metabolism in a patient with typical hemorrhagic stroke in a subacute phase. The patient was evaluated with 18F-FDG PET (18F-fluoro-2-deoxy-D-glucose positron emission tomography) during tDCS brain stimulation at 6, 8, and 10 weeks from the event. The patient underwent the following protocol: baseline cerebral 18F-FDG-PET (T0); cerebral 18F-FDG-PET during anodal-tDCS on the affected hemisphere (T1); and cerebral 18F-FDG-PET during cathodal-tDCS on the unaffected hemisphere (T2).
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3

Renard, Dimitri, Sebastien Dufour, Laurent Collombier, and Pierre Labauge. "Cerebral FDG-PET Hypermetabolism in Carcinomatous Meningitis." European Neurology 66, no. 6 (2011): 332–33. http://dx.doi.org/10.1159/000334096.

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4

Moloney, Patrick, Ruth Boylan, Marwa Elamin, Sean O’Riordan, Ronan Killeen, and Christopher McGuigan. "Semi-quantitative analysis of cerebral FDG-PET reveals striatal hypermetabolism and normal cortical metabolism in a case of VGKCC limbic encephalitis." Neuroradiology Journal 30, no. 2 (2017): 160–63. http://dx.doi.org/10.1177/1971400916689578.

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In the context of delayed autoimmune encephalitis antibody results, functional imaging can support the diagnosis of limbic encephalitis associated with anti-voltage-gated potassium channel complex (VGKCC) antibodies. Here we present a typical case of VGKCC encephalitis in a 69-year-old woman whose symptoms responded to plasmapheresis. A cerebral 18F-fluoro-2-deoxy-d-glucose positron emission tomography (FDG-PET) scan performed prior to commencing treatment revealed striatal hypermetabolism assessed qualitatively and semi-quantitatively, with normal uptake in the cortex and cerebellum when anal
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Ayituhongman, Ameina, Zhang Qizhou, Qin Yongde, Amina Yibulayin, Li Yubin, and Li Xiaohong. "Application of 11C-CHO in the imaging of cerebral alveolar echinococcosis: A prospective study." Medicine 104, no. 21 (2025): e42191. https://doi.org/10.1097/md.0000000000042191.

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11C-acetylcholine (11C-CHO) is a positron emission tomography (PET) radiotracer that has been utilized in the diagnosis and treatment of prostate, esophageal, and lung cancers. This preliminary study aimed to assess the feasibility of using 11C-CHO PET/computed tomography (CT) for imaging cerebral alveolar echinococcosis (CAE). In a prospective single-center study, patients with CAE underwent 18F-fludeoxyglucose (18F-FDG) and 11C-CHO PET/CT imaging. The number and location of lesions detected by the 2 tracers were compared, along with determining the maximum standard uptake value (SUVmax) of t
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Durand-Martel, Pascali, Dominic Tremblay, Catherine Brodeur, and Nancy Paquet. "Autopsy as Gold Standard in FDG-PET Studies in Dementia." Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 37, no. 3 (2010): 336–42. http://dx.doi.org/10.1017/s0317167100010222.

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Positron emission tomography (PET) imaging with F18-fluorodeoxyglucose (FDG) is increasingly used as an adjunct to clinical evaluation in the diagnosis of dementia. Considering that most FDG-PET studies in dementia use clinical diagnosis as gold standard and that clinical diagnosis is approximately 80% sensitive or accurate, we aim to review the evidence-based data on the diagnostic accuracy of brain FDG-PET in dementia when cerebral autopsy is used as gold standard. We searched the PubMed and Medline databases for dementia-related articles that correlate histopathological diagnosis at autopsy
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7

Høilund-Carlsen, Poul F., Abass Alavi, and Jorge R. Barrio. "PET/CT/MRI in Clinical Trials of Alzheimer’s Disease." Journal of Alzheimer's Disease 101, s1 (2024): S579—S601. http://dx.doi.org/10.3233/jad-240206.

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With the advent of PET imaging in 1976, 2-deoxy-2-[18F]fluoro-D-glucose (FDG)-PET became the preferred method for in vivo investigation of cerebral processes, including regional hypometabolism in Alzheimer’s disease. With the emergence of amyloid-PET tracers, [11C]Pittsburgh Compound-B in 2004 and later [18F]florbetapir, [18F]florbetaben, and [18F]flumetamol, amyloid-PET has replaced FDG-PET in Alzheimer’s disease anti-amyloid clinical trial treatments to ensure “amyloid positivity” as an entry criterion, and to measure treatment-related decline in cerebral amyloid deposits. MRI has been used
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8

Heckmann, Josef G., Wolfgang Niedermeier, Markus Büchner, and Bernhard Scher. "Distinctive FDG-PET/CT Findings in Acute Neurological Hospital Care." Neurohospitalist 9, no. 2 (2018): 93–99. http://dx.doi.org/10.1177/1941874418805339.

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A compilation of 6 distinctive 18F-fluorodeoxyglucose positron emission tomography (PET) combined with computed tomography (CT) findings in the acute setting of neurohospital care is presented. In case 1, PET/CT allowed the final diagnosis of circumscribed ischemic infarction by demonstrating a clear pattern of luxury perfusion. In case 2, diagnosis of thalamic abscess was made, whereby PET/CT demonstrated an empty zone. Hypermetabolic enlarged hilar lymph nodes and hypermetabolic spinal lumbar roots in PET/CT led to the diagnosis of neurosarcoidosis in case 3. In case 4, a hypermetabolic brai
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9

Seiffert, Alexander P., Adolfo Gómez-Grande, Alberto Villarejo-Galende, et al. "High Correlation of Static First-Minute-Frame (FMF) PET Imaging after 18F-Labeled Amyloid Tracer Injection with [18F]FDG PET Imaging." Sensors 21, no. 15 (2021): 5182. http://dx.doi.org/10.3390/s21155182.

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Dynamic early-phase PET images acquired with radiotracers binding to fibrillar amyloid-beta (Aβ) have shown to correlate with [18F]fluorodeoxyglucose (FDG) PET images and provide perfusion-like information. Perfusion information of static PET scans acquired during the first minute after radiotracer injection (FMF, first-minute-frame) is compared to [18F]FDG PET images. FMFs of 60 patients acquired with [18F]florbetapir (FBP), [18F]flutemetamol (FMM), and [18F]florbetaben (FBB) are compared to [18F]FDG PET images. Regional standardized uptake value ratios (SUVR) are directly compared and intrap
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10

Maza, Sofiane, Ralph Buchert, Winfried Brenner, et al. "Brain and whole-body FDG-PET in diagnosis, treatment monitoring and long-term follow-up of primary CNS lymphoma." Radiology and Oncology 47, no. 2 (2013): 103–10. http://dx.doi.org/10.2478/raon-2013-0016.

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Background. Positron emission tomography (PET) with F-18-labeled fluorodeoxyglucose (FDG) provides remarkable accuracy in detection, treatment monitoring and follow-up of systemic malignant lymphoma. Its value in the management of patients with primary central nervous system lymphoma (PCNSL) is less clear. Patients and methods. In a prospective trial, 42 FDG-PET examinations were performed in ten immunocompetent patients with newly diagnosed or recurrent PCNSL before and repeatedly during and after the treatment. Brain and whole body FDG-PET were compared to brain MRI and extra-cerebral CT, re
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11

Perani, Daniela. "FDG-PET and amyloid-PET imaging: the diverging paths." Curr Opin Neurol. 27, no. 4 (2014): 405–13. https://doi.org/10.1097/WCO.0000000000000109.

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<strong>Abstract</strong> PURPOSE OF REVIEW:&nbsp;The availability of PET neuroimaging tools for the in-vivo assessment of metabolic dysfunction and amyloid burden in Alzheimer&#39;s disease has opened important methodological and practical issues in the diagnostic design and the conduct of new clinical trials. This review, addressing the different molecular information that the amyloid-PET and fluorodeoxyglucose-PET (FDG-PET) tools can provide, highlights their diverging paths in Alzheimer&#39;s disease and possible new perspectives in research and clinical applications. RECENT FINDINGS:&nbsp
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12

Henkel, Rebecca, Matthias Brendel, Marco Paolini, et al. "FDG PET Data is Associated with Cognitive Performance in Patients from a Memory Clinic." Journal of Alzheimer's Disease 78, no. 1 (2020): 207–16. http://dx.doi.org/10.3233/jad-200826.

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Background: Various reasons may lead to cognitive symptoms in elderly, including the development of cognitive decline and dementia. Often, mixed pathologies such as neurodegeneration and cerebrovascular disease co-exist in these patients. Diagnostic work-up commonly includes imaging modalities such as FDG PET, MRI, and CT, each delivering specific information. Objective: To study the informative value of neuroimaging-based data supposed to reflect neurodegeneration (FDG PET), cerebral small vessel disease (MRI), and cerebral large vessel atherosclerosis (CT) with regard to cognitive performanc
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13

Valk, Peter E., Thomas F. Budinger, Victor A. Levin, Pamela Silver, Philip H. Gutin, and Werner K. Doyle. "PET of malignant cerebral tumors after interstitial brachytherapy." Journal of Neurosurgery 69, no. 6 (1988): 830–38. http://dx.doi.org/10.3171/jns.1988.69.6.0830.

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✓ Positron emission tomography (PET) with rubidium-82 (82Rb) and fluorine-18-fluorodeoxyglucose (18F-FDG) was used to diagnose active tumor recurrence and to differentiate this from radiation injury after interstitial irradiation of malignant gliomas. Patients were studied when they presented with radiological or clinical deterioration after an initial period of posttreatment stabilization. Forty studies were performed in 34 patients. The 82Rb was used as a blood-brain barrier tracer to localize the lesion. Uptake of 18F-FDG by the lesion was then compared to uptake by adjacent brain in order
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Harada, Yae, Kenji Hirata, Naoki Nakayama, et al. "Improvement of cerebral hypometabolism after resection of radiation-induced necrotic lesion in a patient with cerebral arteriovenous malformation." Acta Radiologica Open 4, no. 6 (2015): 205846011558411. http://dx.doi.org/10.1177/2058460115584112.

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A 55-year-old woman underwent radiosurgery for a left cerebral hemisphere arteriovenous malformation (AVM) and developed radiation-induced necrosis causing a massive edema in the surrounding brain tissues. Despite various therapies, the edema expanded to the ipsilateral hemisphere and induced neurological symptoms. The radiation-induced necrotic lesion was surgically removed 4 years after radiosurgery. While the preoperative FDG PET revealed severe hypometabolism in the left cerebrum, the necrotomy significantly ameliorated the brain edema, glucose metabolism (postoperative FDG PET), and sympt
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15

Subtirelu, Robert Christopher, Eric Michael Teichner, Yvonne Su, et al. "Aging and Cerebral Glucose Metabolism: 18F-FDG-PET/CT Reveals Distinct Global and Regional Metabolic Changes in Healthy Patients." Life 13, no. 10 (2023): 2044. http://dx.doi.org/10.3390/life13102044.

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Alterations in cerebral glucose metabolism can be indicative of both normal and pathological aging processes. In this retrospective study, we evaluated global and regional neurological glucose metabolism in 73 healthy individuals (mean age: 35.8 ± 13.1 years; 82.5% female) using 18F-Fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT). This population exhibited a low prevalence of comorbidities associated with cerebrovascular risk factors. We utilized 18F-FDG-PET/CT imaging and quantitative regional analysis to assess cerebral glucose metabolism. A statistically s
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Pozzi, Federico Emanuele, Daniele Licciardo, Monica Musarra, et al. "Depressive Pseudodementia with Reversible AD-like Brain Hypometabolism: A Case Report and a Review of the Literature." Journal of Personalized Medicine 12, no. 10 (2022): 1665. http://dx.doi.org/10.3390/jpm12101665.

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Recent European guidelines recommend using brain FDG-PET to differentiate between Alzheimer’s disease (AD) and depressive pseudodementia (DP), with specific hypometabolism patterns across the former group, and typically normal or frontal hypometabolism in the latter. We report the case of a 74 years-old man with DP (MMSE 16/30), whose FDG-PET visual rating and semiquantitative analysis closely mimicked the typical AD pattern, showing severe hypometabolism in bilateral precuneus, parietal and temporal lobes, and sparing frontal areas, suggesting the diagnosis of moderate AD. Shortly after start
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Yu, Mi-Hee, Ji Sun Lim, Hyon-Ah Yi, Kyoung Sook Won, and Hae Won Kim. "Association between Visceral Adipose Tissue Metabolism and Cerebral Glucose Metabolism in Patients with Cognitive Impairment." International Journal of Molecular Sciences 25, no. 13 (2024): 7479. http://dx.doi.org/10.3390/ijms25137479.

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Visceral adipose tissue (VAT) dysfunction has been recently recognized as a potential contributor to the development of Alzheimer’s disease (AD). This study aimed to explore the relationship between VAT metabolism and cerebral glucose metabolism in patients with cognitive impairment. This cross-sectional prospective study included 54 patients who underwent 18F-fluorodeoxyglucose (18F-FDG) brain and torso positron emission tomography/computed tomography (PET/CT), and neuropsychological evaluations. VAT metabolism was measured by 18F-FDG torso PET/CT, and cerebral glucose metabolism was measured
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18

Moradiya, Priyankkumar G., Rahul S. Mahajan, Shrikant V. Solav, et al. "Gallium 68-Fibroblast Activation Protein Inhibitor: PET/CT Improves Diagnosis of Neurocysticercosis." Asian Journal of Research in Infectious Diseases 14, no. 2 (2023): 30–35. http://dx.doi.org/10.9734/ajrid/2023/v14i2285.

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F18-FDG (Fluorine18- fluoro-deoxyglucose) Positron emission tomography/computerized tomography scan (PET/CT Scan) scan shows intense physiologic uptake in the brain parenchyma. This prevents evaluation of small cerebral lesions. Ga-68-FAPI (Gallium68- Fibroblast activation protein inhibitor) does not localize in normal brain parenchyma. Hence, it can detect cerebral lesions which concentrate the tracer. We report a case of neurocysticercosis in a 32 years old female who presented with headache, nausea and one episode of seizure. MRI brain raised possibility of tuberculoma over neurocysticercos
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19

Blacklock, J. Bob, Edward H. Oldfield, Giovanni Di Chiro, et al. "Effect of barbiturate coma on glucose utilization in normal brain versus gliomas." Journal of Neurosurgery 67, no. 1 (1987): 71–75. http://dx.doi.org/10.3171/jns.1987.67.1.0071.

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✓ Glucose utilization by normal and neoplastic cerebral tissue can be measured in humans using positron emission tomography (PET) with fluorine-18-labeled 2-deoxy-D-glucose (FDG). Malignant gliomas are known to exhibit hypermetabolic glucose consumption compared to normal brain. Barbiturate-sensitive cerebral glucose utilization is coupled to neuronal activity, and lesions lacking neuronal activity should be relatively insensitive to barbiturate suppression of glucose utilization. In a study to examine this phenomenon, three patients with cerebral gliomas underwent FDG-PET while awake and duri
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Yoshida, Koji, Kuniaki Ogasawara, Hiroaki Saura, et al. "Post-carotid endarterectomy changes in cerebral glucose metabolism on 18F-fluorodeoxyglucose positron emission tomography associated with postoperative improvement or impairment in cognitive function." Journal of Neurosurgery 123, no. 6 (2015): 1546–54. http://dx.doi.org/10.3171/2014.12.jns142339.

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OBJECT Cognitive function is often improved or impaired after carotid endarterectomy (CEA) for patients with cerebral hemodynamic impairment. Cerebral glucose metabolism measured using positron emission tomography (PET) with 18F-fluorodeoxyglucose (FDG) correlates with cognitive function in patients with neurodegenerative diseases. The present study aimed to determine whether postoperative changes in cerebral glucose metabolism are associated with cognitive changes after CEA. METHODS In patients who were scheduled to undergo CEA for ipsilateral internal carotid artery (ICA) stenosis (≥ 70% nar
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Kim, Dongwoo, Hae Young Ko, Sangwon Lee, et al. "Glucose Loading Enhances the Value of 18F-FDG PET/CT for the Characterization and Delineation of Cerebral Gliomas." Cancers 12, no. 7 (2020): 1977. http://dx.doi.org/10.3390/cancers12071977.

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This study aimed to assess how to enhance the value of 18F-Fluorodeoxyglucose (FDG) PET/CTs for glioma grading and better delineation of the tumor boundary by glucose loading. In mouse models of brain tumor using U87MG cells, 18F-FDG-PET images were obtained after fasting and after glucose loading. There was a significant difference in the tumor-to-normal cortex-uptake ratio (TNR) between the fasting and glucose-loading scans. 14C-2-Deoxy-D-glucose (14C-DG) uptake was measured in vitro using U87MG, U373MG and primary neurons cultured with different concentrations of glucose. The tumor-to-neuro
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Patronas, Nicholas J., Giovanni Di Chiro, Conrad Kufta, et al. "Prediction of survival in glioma patients by means of positron emission tomography." Journal of Neurosurgery 62, no. 6 (1985): 816–22. http://dx.doi.org/10.3171/jns.1985.62.6.0816.

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✓ The aim of this study was to determine whether positron emission tomography (PET) with fluorine-18 (18F)-2-deoxyglucose (FDG) can be used as a prognostic test in patients with high-grade cerebral gliomas, regardless of the treatment given. Forty-five patients with astrocytoma Grade III or IV were included in this analysis. The mean survival time of patients with tumors exhibiting high glucose utilization as determined by PET-FDG was 5 months, whereas patients with gliomas showing lower glucose utilization had a mean survival period of 19 months. It is postulated that PET-FDG scans reflect th
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23

Kim, Shin, Hyon-Ah Yi, Kyoung Sook Won, Ji Soo Lee, and Hae Won Kim. "Association between Visceral Adipose Tissue Metabolism and Alzheimer’s Disease Pathology." Metabolites 12, no. 3 (2022): 258. http://dx.doi.org/10.3390/metabo12030258.

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The visceral adipose tissue (VAT) has been recognized as an endocrine organ, and VAT dysfunction could be a risk factor for Alzheimer’s disease (AD). We aimed to evaluate the association of VAT metabolism with AD pathology. This cross-sectional study included 54 older subjects with cognitive impairment who underwent 2-deoxy-2-[fluorine-18]-fluoro-D-glucose (18F-FDG) torso positron emission tomography (PET) and 18F-florbetaben brain PET. 18F-FDG uptake in VAT on 18F-FDG PET images was used as a marker of VAT metabolism, and subjects were classified into high and low VAT metabolism groups. A vox
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Perani, Daniela, Cristina Colombo, Sergio Bressi, et al. "[18F]FDG PET Study in Obsessive–Compulsive Disorder." British Journal of Psychiatry 166, no. 2 (1995): 244–50. http://dx.doi.org/10.1192/bjp.166.2.244.

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BackgroundWe used [18F]FDG and PET in patients with obsessive–compulsive disorder (OCD) to evaluate cerebral metabolic involvement before and after treatment with serotonin-specific reuptake inhibitors.MethodIn 11 untreated, drug-free adults, regional cerebral metabolic rate for glucose (rCMRglu) was compared with that of 15 age-matched normal controls.ResultsrCMRglu values were significantly increased in the cingulate cortex, thalamus and pallidum/putamen complex. After treatment a significant improvement in obsessive–compulsive symptoms on the Y-BOC scale (t = 3.59, P &lt; 0.01) was associat
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Harris, Mary Louise, Peter Julyan, Bhavna Kulkarni, et al. "Mapping Metabolic Brain Activation during Human Volitional Swallowing: A Positron Emission Tomography Study Using [18F]fluorodeoxyglucose." Journal of Cerebral Blood Flow & Metabolism 25, no. 4 (2005): 520–26. http://dx.doi.org/10.1038/sj.jcbfm.9600042.

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We have previously shown that labelled water positron emission tomography (H215O PET) can be used to identify regional cerebral blood flow (rCBF) changes in the human brain during volitional swallowing. (18F) fluorodeoxyglucose (FDG PET), by comparison, uses a glucose analogue to quantitatively measure regional cerebral glucose metabolism (rCMRglc) rather than rCBF. The main advantage of FDG PET is improved spatial resolution, and because of its pharmacodynamic properties, activation can be performed external to the scanner, allowing subjects to assume more physiologic positions. We therefore
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Kim, Yeon-Jung, and Sun U. Kwon. "Recurrent steroid-responsive cerebral vasogenic edema in status migrainosus and persistent aura." Cephalalgia 35, no. 8 (2014): 728–34. http://dx.doi.org/10.1177/0333102414553820.

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Background Status migrainosus (SM) and persistent aura (PA) without infarction are complications of migraine. Although several patients have been reported to have reversible brain lesions associated with complications of migraine, their nature and pathophysiology remain unclear. Case We report on a 38-year-old male who presented with nine episodes of SM and PA over eight years. Serial neuroimaging studies including brain magnetic resonance imaging (MRI), blood flow single photon emission tomography (SPECT),18 F-fluorodeoxyglucose positron emission tomography (FDG-PET) and11 C-flumazenil PET (F
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27

Sathekge, M. M., A. Maes, V. Thijst, and M. De Roo. "Hypermetabolism of basal ganglia in chorea associated with antiphospholipid antibodies demonstrated by F-18 FDG." South African Journal of Radiology 2, no. 4 (1997): 14. http://dx.doi.org/10.4102/sajr.v2i4.1630.

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A brain FDG PET study was performed on a 21-year-old woman with subacute chorea of unknown origin. Associated with her chorea, she had abnormal levels of antiphospholipid antibodies. She had none of the classical features of SLE nor primary antiphospholipid syndrome. The images showed high F-18 FDG uptake in the basal ganglia, while the brain MRI and EEG were normal. An association between chorea and antiphospholipid antibodies had been demonstrated before, with normal brain CT, MRI, 123IMPSPECT and cerebral angiography. The report suggests the advantage of FDG PET in imaging of unexplained ca
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Engel, Jerome. "PET Scanning in Partial Epilepsy." Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 18, S4 (1991): 588–92. http://dx.doi.org/10.1017/s0317167100032765.

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ABSTRACT:Many biologically active tracers are available for positron emission tomography (PET) investigations, but most studies of epilepsy have utilized l8F-fluorodeoxyglucose (FDG) to measure local cerebral metabolic rate for glucose. Over 70% of patients with medically refractory partial seizures demonstrate an interictal zone of hypometabolism corresponding to the epileptogenic region. This metabolic defect commonly involves the temporal lobe in patients with complex partial seizures of mesial temporal origin, and is encountered less consistently with seizures of extratemporal neocortical
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29

Martin, W. R. Wayne, and Michael R. Hayden. "Cerebral Glucose and Dopa Metabolism in Movement Disorders." Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 14, S3 (1987): 448–51. http://dx.doi.org/10.1017/s0317167100037896.

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ABSTRACT:The development of positron emission tomography (PET) has enabled us to perform in vivo measurements of certain aspects of regional cerebral function. Regional cerebral glucose metabolism may be readily quantified with [18F] fluoro-2-deoxyglucose (FDG) and presynaptic dopaminergic function may be studied with the labelled dopa analog 6-[18F] fluoro-L-dopa. We have applied a model to the analysis of 6-FD/PET data with which in vivo age-related changes in dopaminergic function may be demonstrated in normal subjects. With this technique, we have studied a series of asymptomatic MPTP-expo
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30

Menendez, Jose A., David L. Lilien, Anil Nanda, and Richard S. Polin. "Use of fluorodeoxyglucose–positron emission tomography for the differentiation of cerebral lesions in patients with acquired immune deficiency syndrome." Neurosurgical Focus 8, no. 2 (2000): 1–4. http://dx.doi.org/10.3171/foc.2000.8.2.3.

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Intracranial mass lesions comprise approximately half of all acquired immune deficiency syndrome (AIDS)–related neurological complications. Although toxoplasmosis and lymphoma are the most common causes of these lesions, diagnosis and treatment can be delayed because computerized tomography and magnetic resonance imaging studies cannot accurately differentiate between them. The authors retrospectively studied nine patients with AIDS in whom, after a 6-hour fast, [18F]-fluorodeoxyglucose (FDG)–positron emission tomography (PET) scanning demonstrated intracranial mass lesions. The FDG uptake wit
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Provost, Karine, Renaud La Joie, Amelia Strom, et al. "Crossed cerebellar diaschisis on 18F-FDG PET: Frequency across neurodegenerative syndromes and association with 11C-PIB and 18F-Flortaucipir." Journal of Cerebral Blood Flow & Metabolism 41, no. 9 (2021): 2329–43. http://dx.doi.org/10.1177/0271678x211001216.

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We used 18F-FDG-PET to investigate the frequency of crossed cerebellar diaschisis (CCD) in 197 patients with various syndromes associated with neurodegenerative diseases. In a subset of 117 patients, we studied relationships between CCD and cortical asymmetry of Alzheimer’s pathology (β-amyloid (11C-PIB) and tau (18F-Flortaucipir)). PET images were processed using MRIs to derive parametric SUVR images and define regions of interest. Indices of asymmetry were calculated in the cerebral cortex, basal ganglia and cerebellar cortex. Across all patients, cerebellar 18F-FDG asymmetry was associated
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32

Iaccarino, Leonardo, Konstantinos Chiotis, Pierpaolo Alongi, et al. "A Cross-Validation of FDG- and Amyloid-PET Biomarkers in Mild Cognitive Impairment for the Risk Prediction to Dementia due to Alzheimer's Disease in a Clinical Setting." Journal of Alzheimer's Disease 59, no. 2 (2017): 603–14. https://doi.org/10.3233/JAD-170158.

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<strong>Abstract</strong> Assessments of brain glucose metabolism (18F-FDG-PET) and cerebral amyloid burden (11C-PiB-PET) in mild cognitive impairment (MCI) have shown highly variable performances when adopted to predict progression to dementia due to Alzheimer&#39;s disease (ADD). This study investigates, in a clinical setting, the separate and combined values of 18F-FDG-PET and 11C-PiB-PET in ADD conversion prediction with optimized data analysis procedures. Respectively, we investigate the accuracy of an optimized SPM analysis for 18F-FDG-PET and of standardized uptake value ratio semiquant
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Gil Martínez, E. M., M. A. Ramírez López, F. Moya García, and P. González Cabezas. "Control evolutivo con PET-FDG cerebral de pinealoblastoma metastásico." Revista Española de Medicina Nuclear 25, no. 1 (2006): 40. http://dx.doi.org/10.1157/13083349.

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Wolf, Emily, Madiha Iqbal, Zhuo Li, Han W. Tun, and Ephraim E. Parent. "Chimeric Antigen Receptor T-Cell Therapy Associated Cerebral Glucose Hypometabolism (CART-CGHM): A Novel Cerebral Metabolic Complication." Blood 144, Supplement 1 (2024): 3418. https://doi.org/10.1182/blood-2024-206396.

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Introduction: CAR-T (chimeric antigen receptor T-cell) therapy is known to be associated with immune-mediated toxicities including cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS). [18F]-Flurodeoxyglucose-positron emission tomography (FDG-PET) is frequently utilized for cancer staging before and after CAR-T therapy. Case series have demonstrated cerebral glucose hypometabolism (CGHM) on FDG-PET imaging in patients who developed CRS and ICANS. In this study, we aim to further characterize CART-CGHM. Methods: Patients who received CAR-T therapy a
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Hua, Chiaho, Barry L. Shulkin, Daniel J. Indelicato, et al. "Postoperative cerebral glucose metabolism in pediatric patients receiving proton therapy for craniopharyngioma." Journal of Neurosurgery: Pediatrics 16, no. 5 (2015): 567–73. http://dx.doi.org/10.3171/2015.4.peds159.

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OBJECT The aim of the study was to document postoperative cerebral glucose distribution before proton therapy using F-18 fluorodeoxyglucose positron emission tomography (FDG PET) in children with craniopharyngioma. METHODS Between August 2011 and April 2014, 50 patients (20 males, 30 females) enrolled in a prospective trial for craniopharyngioma underwent FDG PET imaging before proton therapy. Proton therapy was delivered using doublescattered beams with a total prescribed dose of 54 cobalt gray equivalent. Tracer uptake in each of 63 anatomical regions was computed after warping PET images to
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Martín, Abraham, Vanessa Gómez-Vallejo, Eneko San Sebastián, et al. "In Vivo Imaging of Dopaminergic Neurotransmission after Transient Focal Ischemia in Rats." Journal of Cerebral Blood Flow & Metabolism 33, no. 2 (2012): 244–52. http://dx.doi.org/10.1038/jcbfm.2012.162.

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The precise biologic mechanisms involved in functional recovery processes in response to stroke such as dopaminergic neurotransmission are still largely unknown. For this purpose, we performed in parallel in vivo magnetic resonance imaging and positron emission tomography (PET) with [18F]fluorodeoxyglucose ([18F]FDG) and [11C]raclopride at 1, 3, 7, 14, 21, and 28 days after middle cerebral artery occlusion in rats. In the ischemic territory, PET [18F]FDG showed a initial decrease in cerebral metabolism followed by a time-dependent recovery to quasi-normal values at day 14 after ischemia. The P
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Tsukada, Hideo, Hiroyuki Ohba, Shingo Nishiyama, Masakatsu Kanazawa, Takeharu Kakiuchi, and Norihiro Harada. "PET Imaging of Ischemia-Induced Impairment of Mitochondrial Complex I Function in Monkey Brain." Journal of Cerebral Blood Flow & Metabolism 34, no. 4 (2014): 708–14. http://dx.doi.org/10.1038/jcbfm.2014.5.

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To assess the capability of 18F-2-tert-butyl-4-chloro-5-{6-[2-(2-fluoroethoxy)-ethoxy]-pyridin-3-ylmethoxy}-2H-pyridazin-3-one (18F-BCPP-EF), a novel positron emission tomography (PET) probe for mitochondrial complex I (MC-I) activity, as a specific marker of ischemia-induced neuronal death without being disturbed by inflammation, translational research was conducted using an animal PET in ischemic brains of Cynomolgus monkeys ( Macaca fascicularis). Focal ischemia was induced by the right middle cerebral artery occlusion for 3 hours, then PET scans were conducted at Day-7 with 15O-gases for r
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Le Goubey, Jean-Baptiste, Charline Lasnon, Ines Nakouri, et al. "18F-FDG PET/CT versus Diagnostic Contrast-Enhanced CT for Follow-Up of Stage IV Melanoma Patients Treated by Immune Checkpoint Inhibitors: Frequency and Management of Discordances over a 3-Year Period in a University Hospital." Diagnostics 11, no. 7 (2021): 1198. http://dx.doi.org/10.3390/diagnostics11071198.

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Aim: To perform a comprehensive analysis of discordances between contrast-enhanced CT (ceCT) and 18F-FDG PET/CT in the evaluation of the extra-cerebral treatment monitoring in patients with stage IV melanoma. Materials and methods: We conducted a retrospective monocentric observational study over a 3-year period in patients referred for 18F-FDG PET/CT and ceCT in the framework of therapy monitoring of immune checkpoint (ICIs) as of January 2017. Imaging reports were analyzed by two physicians in consensus. The anatomical site responsible for discordances, as well as induced changes in treatmen
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Fulham, Michael J., Arturo Brunetti, Luigi Aloj, Ramesh Raman, Andrew J. Dwyer, and Giovanni Di Chiro. "Decreased cerebral glucose metabolism in patients with brain tumors: an effect of corticosteroids." Journal of Neurosurgery 83, no. 4 (1995): 657–64. http://dx.doi.org/10.3171/jns.1995.83.4.0657.

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✓ The authors measured cerebral glucose metabolism (CMRglu) using [18F]fluoro-2-deoxyglucose (FDG) positron emission tomography (PET) in patients with brain tumors to evaluate the effect of exogenous corticosteroids (in this instance, dexamethasone) on glucose metabolism. Fifty-six FDG-PET studies obtained in 45 patients with unilateral supratentorial brain tumors were analyzed. Patients with brain tumors were divided into three groups: 1) patients with cushingoid symptoms, who had been treated with combinations of radiotherapy and chemotherapy taking oral dexamethasone; 2) patients not taking
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Cabrera-Martín, M. N., P. Romero Fernández, M. K. Meneses Navas, et al. "High Grade tumor vs stroke. Utility of PET and MRI corregistration." ANALES RANM 138, no. 138(02) (2021): 176–79. http://dx.doi.org/10.32440/ar.2021.138.02.cc01.

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Sometimes, the clinical presentation of a brain tumour mimics that of stroke or viceversa. In these cases it is useful to evaluate follow-up with MR. The coregistration of PET and MR images improves the diagnostic performance of both techniques. In the area of interest, FDG uptake of any degree, with reference to the adjacent brain tissue uptake, should be considered suggestive of tumor if it corresponds to brain injury in MR, even when the FDG uptake is equal to or lower than that of the normal cerebral cortex. We present a case in which coregistration of images from both techniques contribut
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Bergsneider, Marvin, David A. Hovda, Ehud Shalmon, et al. "Cerebral hyperglycolysis following severe traumatic brain injury in humans: a positron emission tomography study." Journal of Neurosurgery 86, no. 2 (1997): 241–51. http://dx.doi.org/10.3171/jns.1997.86.2.0241.

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✓ Experimental traumatic brain injury studies have shown that cerebral hyperglycolysis is a pathophysiological response to injury-induced ionic and neurochemical cascades. This finding has important implications regarding cellular viability, vulnerability to secondary insults, and the functional capability of affected regions. Prior to this study, posttraumatic hyperglycolysis had not been detected in humans. The characteristics and incidence of cerebral hyperglycolysis were determined in 28 severely head injured patients using [18F]fluorodeoxyglucose—positron emission tomography (FDG-PET). Th
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Gao, Zhong-Bao, Wei Wang, Xing-Li Zhao, et al. "Multi-modality molecular imaging characteristics of dementia with Lewy bodies." Journal of International Medical Research 46, no. 6 (2018): 2317–26. http://dx.doi.org/10.1177/0300060518764749.

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Objective Dementia with Lewy bodies (DLB) is a common type of neurodegenerative dementia. Molecular neuroimaging using dopamine transporter (DaT), Pittsburgh compound B (PIB), and fluorodeoxyglucose (FDG) positron emission tomography (PET) has advantages in detecting dopaminergic neuron loss, abnormal amyloid β-protein deposition, and glucose metabolism changes in patients with neurodegenerative disorders. However, the multi-modality molecular imaging features of patients with DLB have rarely been reported. Methods Five patients with a probable diagnosis of DLB were enrolled. PET/magnetic reso
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Reesink, F. E., D. Vállez García, C. A. Sánchez-Catasús, et al. "Crossed Cerebellar Diaschisis in Alzheimer’s Disease." Current Alzheimer Research 15, no. 13 (2018): 1267–75. http://dx.doi.org/10.2174/1567205015666180913102615.

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Background: We describe the phenomenon of crossed cerebellar diaschisis (CCD) in four subjects diagnosed with Alzheimer’s disease (AD) according to the National Institute on Aging - Alzheimer Association (NIA-AA) criteria, in combination with 18F-FDG PET and 11C-PiB PET imaging. Methods: 18F-FDG PET showed a pattern of cerebral metabolism with relative decrease most prominent in the frontal-parietal cortex of the left hemisphere and crossed hypometabolism of the right cerebellum. 11C-PiB PET showed symmetrical amyloid accumulation, but a lower relative tracer delivery (a surrogate of relative
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Kudura, Ken, Florentia Dimitriou, Daniela Mihic-Probst, et al. "Malignancy Rate of Indeterminate Findings on FDG-PET/CT in Cutaneous Melanoma Patients." Diagnostics 11, no. 5 (2021): 883. http://dx.doi.org/10.3390/diagnostics11050883.

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Background: The use of 18F-2-Fluor-2-desoxy-D-glucose Positron Emission Tomography/Computed Tomography FDG-PET/CT in clinical routine for staging, treatment response monitoring and post treatment surveillance in metastatic melanoma patients has noticeably increased due to significant improvement of the overall survival rate in melanoma patients. However, determining the dignity of the findings with increased metabolic activity on FDG-PET/CT can be sometimes challenging and may need further investigation. Purpose: We aimed to investigate the malignancy rate of indeterminate findings on FDG-PET/
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Kaech, D., P. Kalvach, K. Leenders, and U. Roelcke. "PET FDG Study after Severe Head Injury." Rivista di Neuroradiologia 9, no. 1 (1996): 25–35. http://dx.doi.org/10.1177/197140099600900103.

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From a series of 10 patients undergoing PET studies of brain metabolism with 18Fluo-ro-Desoxy-Glucose (FDG) between 18 days and 62 months after a major head injury 3 chronic cases examined 25, 33 and 62 months after the accident are presented to illustrate some neuroradiologic aspects. Cortical defects are easily recognised on PET as zones of decreased metabolism after brain laceration corresponding to the residual neurologic deficits. A crossed cerebellar diaschisis is present, reflecting the deafferentation of the cerebellum. In the patient studied 62 months after a left frontotemporal traum
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Cardoza Ochoa, David Ricardo, Keren Contreras Contreras, Blanca Lucero Abundiz López, Gustavo Vázquez Cardoso, and Belén Rivera Bravo. "Signo de “doble corteza” visualizado en corregistro 18F-FDG PET/RM en un paciente con heterotopia subcortical en banda." Revista de la Facultad de Medicina 65, no. 1 (2022): 37–39. http://dx.doi.org/10.22201/fm.24484865e.2022.65.1.05.

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Subcortical band heterotopia (HSB) refers to the presence of smooth bilateral bands of gray matter located in the subcortical white matter. Clinical presentation is widely variable, the presentation includes intellectual disability, epileptic seizures and varied conduct disorders, making a complex diagnosis. We present a case of a 20-year-old male with a long history of treatment-refractory epilepsy referred to our center for a 18F-FDG (18F-fluorodeoxyglucose) PET/CT (Positron Emission Tomography/Computed Tomography), to search for the epileptogenic focus. Additionally, a registration was carr
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Magis, Delphine, Kevin D’Ostilio, Aurore Thibaut, et al. "Cerebral metabolism before and after external trigeminal nerve stimulation in episodic migraine." Cephalalgia 37, no. 9 (2016): 881–91. http://dx.doi.org/10.1177/0333102416656118.

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Background and aim A recent sham-controlled trial showed that external trigeminal nerve stimulation (eTNS) is effective in episodic migraine (MO) prevention. However, its mechanism of action remains unknown. We performed 18-fluorodeoxyglucose positron emission tomography (FDG-PET) to evaluate brain metabolic changes before and after eTNS in episodic migraineurs. Methods Twenty-eight individuals were recruited: 14 with MO and 20 healthy volunteers (HVs). HVs underwent a single FDG-PET, whereas patients were scanned at baseline, directly after a first prolonged session of eTNS (Cefaly®) and afte
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Schroeter, Michael, Maria A. Dennin, Maureen Walberer, et al. "Neuroinflammation Extends Brain Tissue at Risk to Vital Peri-Infarct Tissue: A Double Tracer [11C]PK11195- and [18F]FDG-PET Study." Journal of Cerebral Blood Flow & Metabolism 29, no. 6 (2009): 1216–25. http://dx.doi.org/10.1038/jcbfm.2009.36.

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Focal cerebral ischemia elicits strong inflammatory responses involving activation of resident microglia and recruitment of monocytes/macrophages. These cells express peripheral benzodiazepine receptors (PBRs) and can be visualized by positron emission tomography (PET) using [11C]PK11195 that selectively binds to PBRs. Earlier research suggests that transient ischemia in rats induces increased [11C]PK11195 binding within the infarct core. In this study, we investigated the expression of PBRs during permanent ischemia in rats. Permanent cerebral ischemia was induced by injection of macrospheres
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Ran, Pengcheng, Cheng Li, Jieqin Lv, Xiang Liang, and Aisheng Dong. "18F-FAPI-42 Versus 18F-FDG PET/MRI in a Case of Primary Peripheral T-Cell Lymphoma of the Skeletal Muscles." Clinical Nuclear Medicine, June 3, 2024. http://dx.doi.org/10.1097/rlu.0000000000005311.

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Abstract Primary skeletal muscle lymphoma is rare. We describe 18F-FAPI-42 and 18F-FDG PET/MRI findings in a case of primary peripheral T-cell lymphoma of the skeletal muscles with brain involvement. The multiple skeletal muscle tumors and one larger cerebral tumor showed intense FDG uptake and mild to moderate FAPI uptake. FDG PET was superior to FAPI PET in delineating the muscle tumors because of significantly higher FDG uptake of the muscle tumors than FAPI uptake. FAPI PET was superior to FDG PET in delineating the cerebral lesion because of a very low background FAPI activity in the brai
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Nowell, Joseph, Grazia Daniela Femminella, Craig Ritchie, et al. "Do glial‐reactivity and cerebral blood flow modulate cerebral glucose metabolism in Alzheimer’s disease?" Alzheimer's & Dementia 20, S2 (2024). https://doi.org/10.1002/alz.088897.

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AbstractBackgroundAlzheimer’s disease is a devastating neurodegenerative disorder with a complex pathogenesis. One main pathological feature utilised in diagnosis is neurodegeneration or neuronal injury, which is reflected in reductions in cerebral glucose metabolism measured by [18F]Fluorodeoxyglucose ([18F]FDG) positron emission tomography (PET). Here we evaluated the involvement of glial reactivity measured with magnetic resonance spectroscopy (MRS) and cerebral blood flow measured with arterial spin labelling (ASL) on [18F]FDG PET as a measure of cerebral glucose metabolism.Method123 peopl
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