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Dissertations / Theses on the topic 'Cerebral ischemia – Animal models'

Author: Grafiati
Published: 4 June 2021
Last updated: 1 February 2022

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1

Ng, Kit-ying, and 吳潔瑩. "Neuroprotective effects of adiponectin in focal cerebral ischemia." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B39634371.

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2

Tsang, Hing-wai, and 曾慶威. "In vitro studies of hypoxic ischemic down-regulated 1 (HID-1) protein encoded by a novel gene down-regulated in neonatal hypoxic-ischemicencephalopathy in different cell death paradigms." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B45608192.

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3

Mullins, Paul Gerald Mark. "Magnetic resonance imaging in the study of animal models of cerebral ischaemia /." [St. Lucia, Qld.], 2001. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe16186.pdf.

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4

Liu, Lingguang, and 刘灵光. "Neuroprotection of melatonin and/or electro-acupuncture in a rat model of focal cerebral ischemia." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hdl.handle.net/10722/198928.

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Stroke is a serious cerebral vascular event and a leading cause of death and disability worldwide, and ischemic stroke is the most common type. Evidence from animal research in acute cerebral ischemia shows that a combination of neuroprotectants might be more efficacious than the single agent given individually. Both melatonin and electro-acupuncture (EA) have been suggested to be effective treatments against cerebral ischemia. However, it is unknown whether a combination of these two therapies could be beneficial against focal cerebral ischemia. In the first study, the effect of post-tr
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5

Chan, Chu-fung, and 陳柱峰. "Neuroprotective effects of granulocyte-colony stimulating factor in a mice stroke model." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B40687284.

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6

Wang, Yanxin, and 王燕欣. "Hypoxic-ischemic injury in the neonatal rat model: prediction of irreversible infarction size by DiffusionWeighted MR Imaging." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2005. http://hub.hku.hk/bib/B35757577.

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7

Sicard, Kenneth M. "Multimodal MRI, Behavioral Testing, and Histology in a Rat Model of Transient Focal Cerebral Ischemia : A Dissertation." eScholarship@UMMS, 2006. http://escholarship.umassmed.edu/gsbs_diss/318.

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Cerebral ischemia is defined as a decrease in blood flow to the brain. It is most often caused by obstruction of a cerebral blood vessel, and is recognized by the World Health Organization as the leading cause of serious adult disability and one of the top three causes of adult death worldwide. Most survivors demonstrate partial restitution of function over time, but the underlying recovery mechanism(s) remain unclear especially in a subset of patients with persistent neurological morbidities despite normal-appearing brain on neuroimaging. The optimal way to understand any human disease state
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8

Jeffs, Graham J. "The effect of sodium/calcium exchanger 3 (NCX3) knockout on neuronal survival following global cerebral ischaemia in mice." University of Western Australia. School of Biomedical, Biomolecular and Chemical Sciences, 2007. http://theses.library.uwa.edu.au/adt-WU2008.0063.

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Cerebral ischaemia is a leading cause of disability and death world-wide. The only effective treatments are thrombolytic therapy (plasminogen activator; tPA) and hypothermia (33?C). However, tPA has limited clinical application due to its short therapeutic time window and its specific application in thrombo-embolic stroke. Moderate hypothermia (33?C) is only being used following cardiac arrest in comatose survivors. Hence more treatments are urgently required. The first step in developing new treatments is the identification and characterisation of a potential therapeutic target. Since brain d
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9

Brodin, Camille. "De la paillasse au lit du patient, surmonter les problèmes de translation dans le domaine de l'AVC ischémique Single- and two- chain tissue plasminogen activator treatment differentially influence cerebral recovery after stroke Single- and two- chain tissue plasminogen activator treatment differentially influence cerebral recovery after stroke Cerebral blood flow correlates with ischemic brain lesion only when Stroke occurs awake: a preclinical model to bypass the translational roadblocks to clinic." Thesis, Normandie, 2019. http://www.theses.fr/2019NORMC427.

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Les défauts de translation des études précliniques vers les essais cliniques dans le domaine des AVC ischémiques et l'échec des développements thérapeutiques pourraient être expliqués par trois aspects : (1) le manque de compréhension des mécanismes des deux formes de rtPA, le traitement pharmacologique de l'AVC; (2) le manque d'outils adaptés d'imagerie de perfusion chez le petit animal et (3) l'influence de l'anesthésie sur l’effet des traitements testés dans les modèles animaux.Le tPA utilisé en clinique (Actilyse®) est un mélange de deux formes de tPA: une forme chaîne simple (sc-rtPA) et
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10

Chaparro-Buitrago, Rafael Eduardo. "Neuroprotection with Anesthetics in Two Models of Cerebral Ischemia." Scholar Commons, 2010. http://scholarcommons.usf.edu/etd/3521.

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Neuroprotection with anesthetics has been studied for many decades; important advances in this field have modified the way Anesthesiologists treat patients in the operating room. Animal models have played an important role in the study of ischemia in the operating room. Recent studies have demonstrated that the effect of anesthetics seems to be different in different animal models. We decided to evaluate anesthetics in a well-known model of cerebral ischemia and also in hypotensive models designed by us. We used a model of cerebral ischemia (MCAO) to test anesthetics neuroprotective effect in
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11

Thomas, Sunu Samuel. "Murine models of cerebral ischemia, development of a mouse model of global cerebral ischemia; response of GluR2 knockout mice in a model of permanent focal cerebral ischemia." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0026/MQ50439.pdf.

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12

Zur, Nedden Stephanie. "Targeting the purine salvage pathway in in vitro models of cerebral ischemia." Thesis, University of Warwick, 2011. http://wrap.warwick.ac.uk/45926/.

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An interruption of the blood supply to the brain, as occurs during ischemic stroke, results in a rapid decline of ATP levels and a subsequent loss of neuronal function and viability. Under physiological conditions the brain reuses ATP degradation metabolites, such as hypoxanthine, via the purine salvage pathway, to restore its ATP pool. However, the massive degradation of ATP during ischemia results in the accumulation and loss of diffusible purine metabolites and thereby leads to a reduction in the post-ischemic ATP pool size, leaving the brain more vulnerable to secondary ischemic insults (r
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13

Messager, Tristan. "Etude d'un accident ischemique cerebral fonctionnel par irm, doppler pulse et video angiometrie cerebrale (doctorat : signaux et images en biologie et medecine)." Angers, 2000. http://www.theses.fr/2000ANGE0502.

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14

von, Geymüller Teresa. "Einfluss einer autologen Knochenmarkzelltherapie auf reaktive Astrogliose und Glukosetransporter-1-Expression in grauer und weißer Substanz des Großhirns nach fokaler zerebraler Ischämie beim Schaf." Doctoral thesis, Universitätsbibliothek Leipzig, 2012. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-98722.

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Ziele der hier vorliegenden Arbeit waren eine immunhistochemische Analyse von GFAP (‚glial fibrillary acidic protein’) und GLUT-1 (Glukosetransporter-1) nach fokaler zerebraler Ischämie sowie deren mögliche Beeinflussung durch eine intravenöse Transplantation autologer mononukleärer Knochenmarkzellen (mKMZ) im Schafmodell. Eine differenzierte Analyse der Zielstrukturen in grauer und weißer Substanz (GS bzw. WS) sollte Aufschluss über eventuell unterschiedliche Reaktionsmuster liefern. Das Gehirnmaterial von zehn Tieren der bereits 2006/2007 stattgefundenen Studie, welche mit PET und MRT-Unters
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15

Lui, Sing-leung, and 雷聲亮. "Therapeutic potential of rapamycin in renal parenchymal diseases: insights from murine models of lupusnephritis, adriamycin nephropathy and renal ischemia reperfusioninjury." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2008. http://hub.hku.hk/bib/B41291013.

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16

Wu, Ona. "Predictive models of tissue outcome in acute human cerebral ischemia using diffusion and perfusion weighted MRI." Thesis, Massachusetts Institute of Technology, 2002. http://hdl.handle.net/1721.1/8358.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2002.<br>Includes bibliographical references.<br>Diffusion (DWI) and perfusion weighted (PWI) magnetic resonance imaging (MRI) provide significant insight into acute stroke and can potentially be useful for clinical decision-making. In particular, current therapeutic decisions for acute human cerebral ischemia are typically based on time of symptom onset, limiting the number of patients treated. Imaging, however, offers insight into the physiologic integrity of brain tissue that is not
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17

Zhang, Xiaohui. "Analysis of nitric oxide generation in various organs of animal models during ischemia-reperfusion /." Hong Kong : University of Hong Kong, 1999. http://sunzi.lib.hku.hk/hkuto/record.jsp?B21185426.

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18

Rohlicek, Charles Vaclav. "Properties of sympathetic neuron responses to cerebral ischemia and to systemic hypoxia or hypercapnia which suggest mediation by central chemosensitive mechanisms." Thesis, McGill University, 1988. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=75944.

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This thesis concerns the possible existence of central nervous system (CNS) chemosensitive mechanisms influencing sympathetic activity. The thesis is based on observations of sympathetic neuron and cardiovascular responses to CNS ischemia, systemic hypoxia and systemic hypercapnia. Investigation of the pressor response to cerebral ischemia in the cat indicates that it is mediated by superficial regions of the ventral medulla also involved in the pressor response to central hypercapnia. Experiments concerning the sympathetic response to systemic hypoxia in the CNS-intact sino-aortic denervated
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19

Menard, Janet L. "Effects of intra-cerebral infusion of anxiolytic compounds in animal models of anxiety." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape10/PQDD_0005/NQ39569.pdf.

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20

Liman, Suryamin, and 陳明正. "Ketamine on chronic post-ischemia pain (CPIP) model of complex regional pain syndrome (CRPS) type I in Sprague-Dawley (SD) rats." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B45989448.

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21

Fournet, Gabrielle. "IVIM : modeling, experimental validation and application to animal models." Thesis, Université Paris-Saclay (ComUE), 2016. http://www.theses.fr/2016SACLS367/document.

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Cette thèse porte sur l’étude de la séquence d’imagerie IRM IVIM (« Intravoxel incoherent motion »). Cette séquence permet l’étude des microvaisseaux sanguins tels que les capillaires, artérioles et veinules. Pour être sensible seulement aux groupes de spins non statiques dans les tissus, des gradients de diffusion sont ajoutés avant et après l’impulsion 180° d’une séquence d’écho de spin. La composante du signal correspondant aux spins qui diffusent dans le tissu peut être séparée de celle des spins en mouvement dans les vaisseaux sanguins qui est appelée signal IVIM. Ces deux composantes son
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22

Geißler, Philippine Camilla. "1H NMR spectroscopy based metabolic profiling of cerebral tissue extracts from animal models of brain disease." Thesis, University of Nottingham, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.555385.

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Background. Over the past decades metabolic profiling has become a valuable tool for the investigation of metabolic changes specific to particular diseases. As this concept considers participants of several metabolic networks and processes within one analyt- ical step, it has been considered suitable for the investigation of cellular mechanisms underlying brain diseases whose pathological backgrounds are assumed to be inher- ently complex. One main technical platform of metabolic profiling is based on in vitro nuclear magnetic resonance (NMR) spectroscopy: a technique that is also available fo
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23

Lebhardt, Philipp [Verfasser], and Alexander [Akademischer Betreuer] Sartorius. "Combining Optogenetics and fMRI to Study Cerebral Networks in Animal Models / Philipp Lebhardt ; Betreuer: Alexander Sartorius." Heidelberg : Universitätsbibliothek Heidelberg, 2017. http://d-nb.info/1178009831/34.

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24

Nelson, Alan John. "Cognitive deficit by global cerebral ischaemia in the rat : strategies to promote functional recovery by drug treatment and neural transplantation." Thesis, King's College London (University of London), 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.265185.

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25

Hinken, Aaron C. "Effects of ischemic metabolites and chronic exercise on cardiac myocyte function." Diss., Columbia, Mo. : University of Missouri-Columbia, 2005. http://hdl.handle.net/10355/4150.

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Thesis (Ph. D.)--University of Missouri-Columbia, 2005.<br>The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Vita. "May, 2005" Includes bibliographical references.
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26

Poignet, Hervé. "Activites pharmacologiques des antagonistes du calcium sur differents modeles physiopathologiques utilises dans l'ischemie cerebrale experimentale : effets sur les atteintes fonctionnelles et neuronales." Clermont-Ferrand 2, 1988. http://www.theses.fr/1988CLF21111.

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27

Hadour, Ghislaine. "Étude expérimentale de la dysfonction myocardique au cours de la mort cérébrale." Lyon 1, 2000. http://www.theses.fr/2000LYO1T157.

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28

Mendes, Fernanda Figueiredo. "O extrato etanólico da casca de pequi reduz o dano cerebral induzido em ratas submetidas à dieta hipercalórica." Universidade Federal de Goiás, 2017. http://repositorio.bc.ufg.br/tede/handle/tede/8152.

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Gonzalez, Claudia L. R., and University of Lethbridge Faculty of Arts and Science. "An analysis of poststroke motor dysfunction and cerebral reorganization in rats." Thesis, Lethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 2004, 2004. http://hdl.handle.net/10133/15.

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This thesis investigates the behavioural and anatomical correlates of recovery from motor cortex damage in rats. The effectiveness of behavioural, pharmacological, and regenerative treatments was investigated using models of focal stroke. Chronic bilateral motor deficits were found after motor cortex damage induced by various methods. These behavioural deficits were similar in severity and duration although they were correlated with different patterns of reorganization seen in Golgi-stained tissue. Animals with motor cortex injury benefited from postinjury olfactory stimulation, chronic ad
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30

Ho, Tsun-bond Horace, and 何存邦. "Generation of Na+-coupled dicarboxylate cotransporter (NaDC-1) deficient mice for the study of NaDC-1's role in caloric restrictionand renal ischemia/reperfusion injury." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B38575231.

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31

Karthikeyan, Sai Sudarshan. "Characterization of Spontaneous Motor Recovery and Changes in Plasticity-Limiting Perineuronal Nets Following Cortical and Subcortical Stroke." Thesis, Université d'Ottawa / University of Ottawa, 2017. http://hdl.handle.net/10393/36812.

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Stroke is a leading cause of neurological disability, often resulting in long-term motor impairments due to damage to the striatum and/or motor cortex. While both humans and animals show spontaneous recovery following stroke, little is known about how the injury location affects recovery and what causes recovery to plateau. This information is essential in order to improve current rehabilitation practice and develop new therapies to enhance recovery. In this thesis, we used endothelin-1 (ET-1), a potent vasoconstrictor, to produce focal infarcts in the forelimb motor cortex (FMC), the dorsolat
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32

Neto, Josà Ananias Vasconcelos. "PadronizaÃÃo de modelo de ligadura da artÃria uterina em ratas nÃo-grÃviadas, seus efeitos sobre a isquemia uterina direta e suas repercussÃes reprodutivas." Universidade Federal do CearÃ, 2009. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=4826.

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CoordenaÃÃo de AperfeiÃoamento de Pessoal de NÃvel Superior<br>A obstruÃÃo das artÃrias uterinas promove isquemia e/ou necrose no Ãtero, no entanto nÃo se conhece com que intensidade essas lesÃes ocorrem. Os objetivos deste estudo sÃo: descrever e padronizar uma tÃcnica de ligadura da artÃria uterina (LAU) direita em ratas nÃo grÃvidas e avaliar os efeitos deste modelo em Ãteros e ovÃrios de ratas. Estudo experimental, utilizando 64 ratos, 48 fÃmeas e 16 machos (Rattus norvergicus, variedade albina) maduros, de fertilidade comprovada. As ratas foram alocadas aleatoriamente em 8 grupos, de seis
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33

Gharbawie, Omar A., and University of Lethbridge Faculty of Arts and Science. "Modeling middle cerebral artery stroke in rats : an examination of the skilled reaching impairments." Thesis, Lethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 2006, 2006. http://hdl.handle.net/10133/388.

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Middle cerebral artery (MCA) stroke can produce chronic incapacitating motor impairments. Understanding the neural basis of the motor syndromes is complicated by the diversity of neural structures damaged but the problem can be addressed in laboratory rats by inducing selective infarcts. Nevertheless, the motor syndromes that ensue from stroke in rats remain poorly understood and undermine its potential as a model for clinical stroke. The objective of the present thesis was to document the skilled reaching impairments from neocortical and subcortical MCA infarcts in rats. In addition, the inte
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34

Jorge, Gracinda de Lourdes 1958. "Avaliação histológica e bioquímica tardia em ratos Wistar após o clampeamento do pedículo hepático : modelos experimentais." [s.n.], 2015. http://repositorio.unicamp.br/jspui/handle/REPOSIP/312714.

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Orientadores: Ilka de Fátima Santana Ferreira Boin, Artur Udelsmann<br>Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas<br>Made available in DSpace on 2018-08-27T00:05:18Z (GMT). No. of bitstreams: 1 Jorge_GracindadeLourdes_D.pdf: 6636878 bytes, checksum: 9167ec95670521d52d8c88a19fc3ceb9 (MD5) Previous issue date: 2015<br>Resumo: A oclusão vascular temporária do fluxo hepático é um dos procedimentos essenciais nas cirurgias hepáticas. Muitas pesquisas relacionadas à isquemia e reperfusão (I/R) em ratos Wistar, seja através de interrupção por pouco tempo, ou
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35

Soares, Matheus Schmidt. "Avaliação da hemodinâmica cerebral através da técnica de ultrassonografia Doppler e suas correlações com as variações da pressão intracraniana em um modelo animal de hipertensão intracraniana." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/5/5138/tde-02072018-122524/.

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Introdução: O aumento da pressão intracraniana (PIC) é um problema comum na prática neurocirúrgica, e a monitoração invasiva deste parâmetro faz parte da rotina de unidades de terapia intensiva. O Doppler transcraniano vem sendo testado na avaliação da hemodinâmica cerebral como parâmetro de avaliação não invasiva da PIC, porém há controvérsias na literatura sobre seu real benefício e utilidade nesta situação. Este estudo objetivou correlacionar os dados de avaliação do fluxo sanguíneo cerebral através da técnica de Doppler com as variações da monitoração invasiva da PIC na fase aguda de hiper
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36

Pinho-Apezzato, Maria Lúcia de. "Lesão causada pela isquemia seguida de reperfusão em modelo experimental de transplante de intestino em porcos jovens: avaliação por meio de métodos histológicos, imunoistoquímicos e de biologia molecular." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/5/5132/tde-24032011-144654/.

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INTRODUÇÃO: O transplante de intestino (TI) estabeleceu-se como tratamento para pacientes com falência intestinal e complicações da nutrição parenteral. Entretanto, sepse continua sendo a principal causa de mortalidade. A lesão causada pela isquemia seguida de reperfusão (LIR) é apontada como um dos fatores de ruptura da barreira mucosa intestinal, com consequente translocação bacteriana e sepse, seja precocemente, por lesão epitelial direta, seja mais tardiamente pela sua associação com o desenvolvimento da rejeição celular aguda. Criou-se um modelo de TI em porcos jovens com a finalidade de
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37

Castaño, Prat Patricia. "Oscilaciones lentas en la red cortical alterada: una caracterización de los modelos murinos 3xTg-AD, SAMP8 y Fmr1KO." Doctoral thesis, Universitat de Barcelona, 2017. http://hdl.handle.net/10803/593487.

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A lo largo de esta tesis se han utilizado las oscilaciones lentas (SO), que emergen durante el sueño de onda lenta y bajo el efecto de ciertos tipos de anestesia, como paradigma para detectar alteraciones funcionales en la corteza de varios modelos murinos de la Enfermedad de Alzheimer (AD) y el Síndrome X Frágil (FXS), para monitorizar la progresión de su enfermedad, y para evaluar la efectividad de dos intervenciones terapéuticas. La caracterización detallada de los parámetros de las SO en varias áreas corticales de los modelos de la AD 3xTg-AD y SAMP8 mostró que dichos parámetros se alter
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38

Gentric, Jean-Christophe. "La diversion de flux dans le traitement des anévrismes cérébraux : des études pré-cliniques aux études cliniques." Thesis, Brest, 2016. http://www.theses.fr/2016BRES0027/document.

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Les avancées technologiques endovasculaires des dernières décennies ont été nombreuses ; la diversion de flux en fait partie. Lorsqu’une nouvelle approche permet de traiter de façon efficace et sûre un certain nombre de patients présentant des défis jusque-là difficiles à surmonter, son adoption en pratique clinique peut-être précoce, voire prématurée. Nous avons dans un premier travail réalisé une revue systématique sur les stents dits «Flow Diverters» (FD) et les modèles animaux. Puis nous avons mené quatre expérimentations animales évaluant l’efficacité des FDs dans différents modèles d’ané
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39

Menezes, Arteiro Queiroz. "Estudo de pulmões de ratos reperfundidos em um modelo experimental ex-vivo: comparação entre duas soluções de preservação (Perfadex® e Celsior®)." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/5/5156/tde-09082013-120744/.

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INTRODUÇÃO: A lesão de isquemia-reperfusão continua sendo considerada a maior causa de mortalidade relacionada ao transplante de pulmão e sua gravidade é influenciada por diversos fatores, dentre eles, a preservação pulmonar. OBJETIVO: Comparar duas soluções de preservação pulmonar, Perfadex® e Celsior®, quanto a capacidade de preservação de tecido pulmonar isquêmico. MÉTODOS: Sessenta pulmões de ratos preservados com Perfadex®, Celsior® ou solução salina após períodos de isquemia hipotérmica de 6 ou 12 horas, foram reperfundidos com sangue homólogo em modelo experimental ex-vivo durante 60 mi
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40

Leal, Antonio Jose Gonçalves e. "Modelo de transplante hepático large-for-size em suínos: estudos bioquímicos, histológicos, moleculares e efeito do pré-condicionamento isquêmico." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/5/5132/tde-26092013-155601/.

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INTRODUÇÃO: O transplante hepático se consolidou como terapêutica para crianças com doença hepática em estágio terminal. A principal indicação nessa faixa etária é a atresia das vias biliares, doença colestática que leva à cirrose hepática na maioria dos casos nos primeiros anos de vida mesmo nas crianças submetidas a portoenterostomia. Essas crianças evoluem entre outras complicações com desnutrição grave e necessitam do transplante precocemente. A relação ideal do peso do enxerto hepático e o peso do receptor varia de 1 a 3%. No entanto, quando o transplante é realizado em crianças em idade
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41

Barandier, Christine. "Potentiel thérapeutique du manganèse et de l'un de ses dérivés synthétiques sur le système cardiovasculaire." Université Joseph Fourier (Grenoble), 1998. http://www.theses.fr/1998GRE10238.

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Le present travail qui s'inscrit dans le cadre general des etudes consacrees a la protection pharmacologique des tissus cardiaque et vasculaire au cours de la reperfusion post-ischemique, comprend deux parties principales. La premiere a ete realisee sur un modele d'ischemie/reperfusion myocardique sur un modele experimental de coeur isole de rat. Les resultats sont exprimes en termes de donnees fonctionnelles, metaboliques et ultrastructurales. La seconde partie est une etude pharmacologique menee sur un modele d'anneaux d'aorte isolee de rat et comporte essentiellement des mesures de contract
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42

Abad, César Cavinato Cal. "Efeitos do treinamento físico contínuo ou intervalado em um modelo experimental de dislipidemia e isquemia miocárdica." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/5/5131/tde-16092013-161614/.

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O infarto do miocárdio (IM) é a doença cardiovascular que mais causa morte e invalidez em todo o mundo. O uso de animais experimentais tem auxiliado a compreender melhor a fisiopatologia e as formas de tratamento do IM. Sabendo que as dislipidemias estão associadas com o IM e que o treinamento físico pode ser prescrito para prevenção e tratamento de doenças cardiovasculares, no presente trabalho, investigamos os efeitos de dois tipos de treinamentos físicos em um modelo experimental de dislipidemia e isquemia miocárdica. Camundongos selvagens (WT) e knockout para o receptor LDL (LDL-/-) foram
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43

Keum, Sehoon. "Genetic Modifiers in Response to Ischemia." Diss., 2010. http://hdl.handle.net/10161/2291.

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<p>In a mouse model of ischemic stroke, infarct volume is highly variable and strain dependent, but the natural genetic determinants responsible for this difference remain unknown. To identify genetic determinants regulating ischemic neuronal damage and to dissect apart the role of individual genes and physiological mechanisms in infarction in mice, we performed forward genetic mapping analyses of surgically induced cerebral infarct volume. We have identified multiple quantitative trait loci (QTL) that modulate infarct volume, with a major locus (<italic>Civq1 </italic>) on chromosome 7 accoun
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44

Laidley, David T. "Increased behavioural and histological variability arising from changes in cerebrovascular anatomy of the Mongolian gerbil /." 2005.

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45

"Potential of serotonin in stem cell technology and therapy in a mouse ischemic stroke model." 2012. http://library.cuhk.edu.hk/record=b5549580.

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Serotonin (5-hydroxytryptamine, 5-HT) is a neurotransmitter involved in the embryonic neural development and adult neurogenesis. But the effects of 5-HT on stem cells are not fully known. In this study, the effects and underlying signal pathways of 5- HT on proliferation and neural differentiation of mouse embryonic stem (ES) cells, neural progenitor (NP) cell line C 17.2 and embryonic neural stem (NS) cells were explored. Molecular analysis, immunostaining and western blotting revealed that NP/NB cells expressed the rate-limiting enzyme tryptophan hydroxylase (TPH) and produced endogenous 5-H
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46

"Baicalin-mediated neuronal induction of neural stem cells and improvement of cognitive function in a mouse stroke model." Thesis, 2009. http://library.cuhk.edu.hk/record=b6074973.

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Baicalin, which is a flavonoid, was previously shown to exert neuroprotective effects against ischemic injury and oxidative insults. In this study, baicalin was found to induce neuronal differentiation on both C17.2 NSC and primary mouse NSC originated from hippocampuses of E14.5 mouse embryos. The baicalin-mediated differentiation of C17.2 NSC was noted in dose- and time-dependent manners. Baicalin-treated NSC displayed long processes of neurites. The gene expression of neuronal markers, NF-L, TUBB3 and MAP2 was also significantly increased after treated with 20 to 50 muM baicalin on C17.2 NS
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47

Lee, E.-Jian, and 李宜堅. "The efficacy of melatonin in experimental models of cerebral ischemia." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/02190578732706149608.

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博士<br>國立成功大學<br>醫學工程研究所碩博士班<br>94<br>The neuroprotective properties of melatonin were evaluated in Sprague-Dawley rats and B6 mice subjected to middle cerebral artery (MCA) occlusion. A series of experiments with delayed treatment of melatonin have been employed to examine whether exogenous melatonin offers neuroprotective action against MCA occlusion which includes ischemic brain damage not only caused by necrotic but also by apoptotic processes. Postmortem infarct volumes will be determined by quantitative image analysis of Nissl-stained brain sections and TTC-staining method. In addition, p
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48

"Actions of protease activated receptors in in vivo and in vitro models of stroke." 2014. http://repository.lib.cuhk.edu.hk/en/item/cuhk-1291499.

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Ischaemic stroke has become one of the leading causes of death and disability in the world. Protease activated receptors (PARs, PAR-1 to PAR-4) belong to G protein coupled receptors that can be self-activated by tethered ligands (TL) revealed through proteolytic cleavage. Based on these TL, many activating peptides (APs) and antagonists have been synthesized to investigate PARs actions.<br>In the present study, the roles of PARs were examined in two models of ischaemic stroke. For the in vivo model, transient middle cerebral artery occlusion (tMCAO) was performed to establish cerebral ischaemi
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49

Kam, Sarah Anne. "Development of models for the study of anesthetic preconditioning using rat pheochromocytoma and mouse neuroblastoma." 2009. http://hdl.handle.net/10090/8913.

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50

(8703303), Andrew J. Boria. "MRI-TRACKABLE MURINE MODEL OF CEREBRAL RADIATION NECROSIS." Thesis, 2020.

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<p>Cerebral radiation necrosis as a consequence of radiation therapy is often observed in patients several months to years after treatment. Complications include painful headaches, seizures, and in the worst-case death. Radiation necrosis is an irreversible condition with the options available to manage it all having noticeable downsides. As such, there is a critical need for better ways of either preventing the onset of necrosis and/or managing its symptoms. As radiation necrosis cannot be induced in humans for ethical reasons, a mouse model that mirrors the features of radiation necrosis obs
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