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Dissertations / Theses on the topic 'Cerebral small vessel disease'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Tan, Yan Ying Rhea. "Genetics of cerebral small vessel disease." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/283203.

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Cerebral small vessel disease (SVD) is a leading cause of stroke and vascular dementia. The majority of cases are sporadic, occurring in the elderly hypertensive population. However, there also exist patients with familial disease. The most common form is Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL), caused by mutations in the NOTCH3 gene. In recent years, other genes have also been found to cause familial SVD, such as COL4A1/A2, HTRA1, FOXC1 and TREX1. Genome wide association studies (GWAS) have also revealed loci associated with sporadi

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2

Potter, Gillian Margaret. "Neuroimaging of cerebral small vessel disease." Thesis, University of Edinburgh, 2011. http://hdl.handle.net/1842/5598.

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Lacunar stroke accounts for one quarter of all ischaemic stroke and in the long term carries a greater risk of death and disability than was previously realised. Much of our current knowledge originated from neuropathological studies in the 1950s and 1960s. In the last thirty years, brain computed tomography (CT) and magnetic resonance imaging (MRI) have revolutionised our understanding of lacunar stroke and associated features of cerebral small vessel disease (SVD), namely white matter lesions (WML), enlarged perivascular spaces (EPVS) and brain microbleeds (BMB). The purpose of the projects

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3

Gormley, Kelly. "The genetic basis of cerebral small vessel disease." Thesis, St George's, University of London, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.441269.

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4

Rannikmäe, Kristiina. "Genetic associations with sporadic cerebral small vessel disease." Thesis, University of Edinburgh, 2017. http://hdl.handle.net/1842/23585.

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Background: Cerebral small vessel disease (SVD) causes substantial cognitive, psychiatric and physical disabilities. Despite its common nature, SVD pathogenesis and molecular mechanisms remain poorly understood, and prevention and treatment are probably suboptimal. Identifying the genetic determinants of SVD will improve understanding and may help identify novel treatment targets. The aim of this thesis is to better understand genetic associations with SVD through investigating its pathological, radiological and clinical phenotypes. Methods: To unravel the genetic associations with SVD, I used

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5

Shi, Yulu. "Cerebral blood flow and intracranial pulsatility in cerebral small vessel disease." Thesis, University of Edinburgh, 2018. http://hdl.handle.net/1842/29625.

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Cerebral small vessel disease (SVD) is associated with increased risks of stroke and dementia, however the mechanisms remain unclear. Low cerebral blood flow (CBF) has long been suggested and accepted, but clinical evidence is conflicting. On the other hand, growing evidence suggests that increased intracranial pulsatility due to vascular stiffening might be an alternative mechanism. Pulse-gated phase-contrast MRI is an imaging technique that allows measuring of CBF contemporaneously with pulsatility in multiple vessels and cerebrospinal fluid (CSF) spaces. The overall aim of this thesis was t

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6

Wiseman, Stewart John. "The role of systemic inflammation in cerebral small vessel disease." Thesis, University of Edinburgh, 2016. http://hdl.handle.net/1842/22915.

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Cerebral small vessel disease (SVD) is a distinct microvascular disorder that can lead to lacunar stroke, an important stroke subtype that accounts for a quarter of all ischaemic strokes. SVD is associated with imaging biomarkers such as white matter hyperintensities (WMH). The cause of SVD is largely unknown, although inflammation and blood-brain barrier failure via endothelial dysfunction have been implicated. Elevated plasma biomarkers of inflammation are associated with coronary heart disease and large vessel stroke but the role of inflammation in SVD is less well understood. Our hypothesi

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7

Khan, Usman. "Studies on the pathogenesis of cerebral small vessel disease." Thesis, University of London, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.539378.

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8

Duperron, Marie-Gabrielle. "Genetic determinants and clinical significance of cerebral small vessel disease." Thesis, Bordeaux, 2019. http://www.theses.fr/2019BORD0449.

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La maladie des petites artères cérébrales (MPAC) constitue une étiologie importante d’accident vasculaire cérébral (AVC), de déclin cognitif et de démence. Les marqueurs en imagerie par résonance magnétique (IRM) de MPAC comprennent les hypersignaux de la substance blanche (HSB), les infarctus lacunaires (IL), les microsaignements (MS) et les espaces dilatés périvasculaires (EdPV). Une revue systématique et méta-analyse incluant plus de 16,000 participants a permis de mieux caractériser l’association des HSB, IL et MS avec le risque d’AVC et de démence, ainsi que leurs sous-types, et la mortal

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9

MELAZZINI, LUCA. "IMAGING BIOMARKERS OF CEREBRAL SMALL VESSEL DISEASE IN ADULTS WITH CONGENITAL HEART DISEASE." Doctoral thesis, Università degli Studi di Milano, 2021. http://hdl.handle.net/2434/805883.

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Aim Imaging biomarkers in medical fields other than oncology tend to be confined to research settings. In neuroimaging, biomarkers of cerebral small vessel disease (SVD) have shown promising results for translation into the clinic but need further validation. In this work, we strove for a more clinically-oriented classification of one of the most representative of SVD biomarkers, i.e. white matter hyperintensities (WMHs), on a large cohort of community-dwelling subjects. We also used this classification to better analyse signs of SVD in a selected population of adults with congenital heart

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10

Lau, Gary Kui Kai. "Cerebral small vessel disease : mechanistic insights, ethnic differences and prognostic value." Thesis, University of Oxford, 2017. https://ora.ox.ac.uk/objects/uuid:5d9d38c7-9239-4264-9b42-836d6dcdec12.

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Small vessel disease (SVD) accounts for approximately 25% of all strokes and 45% of all dementias. Although the small vessels cannot be visualised with conventional neuroimaging, the pathological changes in the cerebral white and deep grey matter secondary to SVD has been adopted as markers of SVD. These are best appreciated with magnetic resonance imaging (MRI) and includes recent small subcortical infarcts, white matter hyperintensity (WMH), lacunes, cerebral microbleeds and enlarged perivascular spaces (PVSs). There are however a number of outstanding questions regarding these surrogate neu

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11

Rajani, Rikesh Mukesh. "Is small vessel disease a disease of the blood brain barrier?" Thesis, University of Edinburgh, 2016. http://hdl.handle.net/1842/25866.

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Cerebral small vessel disease (SVD) is a vascular neurodegenerative disease which is the leading cause of vascular dementia and causes 20% of strokes. 20-30% of those over 80 show signs of the disease as white matter hyperintensities on MRI scans, doubling their risk of stroke and trebling their risk of dementia. Sporadic SVD is thought to be caused by hypertension but 30% of sufferers are normotensive and an alternative hypothesis implicates loss of integrity of the blood brain barrier (BBB). To investigate this, I studied brains from normotensive people with early stage SVD and found reduced

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12

Baykara, Ebru [Verfasser], and Marco [Akademischer Betreuer] Düring. "Imaging markers of cerebral small vessel disease / Ebru Baykara ; Betreuer: Marco Düring." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2018. http://d-nb.info/1173087494/34.

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13

Hassan, Ahmad. "The genetics of ischaemic stroke and the cerebral small vessel disease subtype." Thesis, St George's, University of London, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.407965.

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14

O'Sullivan, Michael. "Cognitive dysfunction and cerebral small vessel disease : exploring the mechanisms with MRI." Thesis, St George's, University of London, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.404817.

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15

Zagten, Maria Sophia Gerarda van. "Cerebral small-vessel disease vascular risk factor profiles, clinical manifestations, and disease progression in stroke /." Maastricht : Maastricht : Universiteit Maastricht ; University Library, Maastricht University [Host], 1997. http://arno.unimaas.nl/show.cgi?fid=6019.

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16

Reitz, Christiane. "Genetic and vascular risk factors for cognitive decline and cerebral small-vessel disease." [S.l.] : [The Author], 2006. http://hdl.handle.net/1765/13309.

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17

Landinger, Timon [Verfasser], and Christof [Akademischer Betreuer] Haffner. "Contractile cell plasticity in inherited cerebral small vessel disease / Timon Landinger ; Betreuer: Christof Haffner." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2021. http://d-nb.info/1233200887/34.

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18

Benjamin, Philip. "A magnetic resonance imaging study evaluating neuro-imaging markers in cerebral small vessel disease." Thesis, St George's, University of London, 2015. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.703111.

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Aims: I investigate potential MRI markers in cerebral small vessel disease (SVD), to determine their relationship to cognitive impairment and investigate whether they are feasible for use as surrogate outcome measures in clinical trials by estimating their sensitivity to longitudinal change and calculating sample sizes for a hypothetical clinical trial. I also carry out pilot work to investigate the potential use of 7T MRI in SVD. Methods: Data from the prospective St Georges Cognition and Neuroimaging in Stroke (SCANS) study of patients with symptomatic SVD was used (n=121). Neuropsychologica

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19

Konieczny, Marek [Verfasser], and Marco [Akademischer Betreuer] Düring. "Clinical application of novel marker for cerebral small vessel disease / Marek Konieczny ; Betreuer: Marco Düring." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2021. http://d-nb.info/1229835636/34.

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20

Chanda, Mullen. "ANTI-S100B Autoantibodies in Cerebral Small Vessel Disease and Brain Metastasis in a Lung Cancer Population." Cleveland State University / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=csu1452097886.

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21

Finsterwalder, Sofia [Verfasser], and Marco [Akademischer Betreuer] Düring. "Diffusion imaging markers of cerebral small vessel disease : validation and application / Sofia Finsterwalder ; Betreuer: Marco Düring." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2020. http://d-nb.info/1218466006/34.

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22

Nylander, Ruta. "Magnetic resonance imaging markers of cerebral small vessel disease in an elderly population – association with cardiovascular disease and cognitive function." Doctoral thesis, Uppsala universitet, Radiologi, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-319766.

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Cerebral small vessel disease (SVD) is identifiable by clinical, neuroimaging, neuropathological and cognitive findings. The aim of this thesis was to assess SVD and cerebral perfusion on magnetic resonance imaging (MRI) in a 75-year-old population and compare the findings with scars of myocardial infarctions, cardiovascular risk markers and cognitive function. In addition, the evolution of SVD over 5 years was studied. The study population included subjects from the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study. The subjects had been chosen in a randomized mann

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23

Nitkunan, Arani. "The use of quantitative magnetic resonance imaging techniques and neuropsychological tests to study cerebral small vessel disease." Thesis, St George's, University of London, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.497769.

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24

Kern, Kyle C., Clinton B. Wright, Kaitlin L. Bergfield, et al. "Blood Pressure Control in Aging Predicts Cerebral Atrophy Related to Small-Vessel White Matter Lesions." FRONTIERS MEDIA SA, 2017. http://hdl.handle.net/10150/624394.

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Cerebral small-vessel damage manifests as white matter hyperintensities and cerebral atrophy on brain MRI and is associated with aging, cognitive decline and dementia. We sought to examine the interrelationship of these imaging biomarkers and the influence of hypertension in older individuals. We used a multivariate spatial covariance neuroimaging technique to localize the effects of white matter lesion load on regional gray matter volume and assessed the role of blood pressure control, age and education on this relationship. Using a case-control design matching for age, gender, and educationa

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25

Wang, Xin. "The role of blood brain barrier failure in progression of cerebral small vessel disease : a detailed magnetic resonance imaging study." Thesis, University of Edinburgh, 2014. http://hdl.handle.net/1842/18744.

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Small vessel disease (SVD) is an important cause of stroke, cognitive decline, and age-related disability. The cause of SVD is unknown, increasing evidence from neuropathology and neuroimaging suggests that failure of the blood-brain barrier (BBB) precipitates or worsens cerebral SVD progression and its failure is associated with SVD features such as white matter hyperintensities (WMH), perivascular spaces (PVS) and lacunar infarcts. The BBB change mechanism may also contribute to other common disorders of ageing such as Alzheimer's disease (AD). Magnetic resonance imaging (MRI) has revolution

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26

Edrissi, Hamidreza. "Blood Brain Barrier Dysfunction in Chronic Cerebral Ischemia." Thesis, Université d'Ottawa / University of Ottawa, 2015. http://hdl.handle.net/10393/32531.

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Cerebral small vessel pathology is now known to be associated with the development of cognitive impairment and mild motor impairments such as gait disturbance in a variety of neurodegenerative diseases. This dissertation explores the hypothesis that blood brain barrier dysfunction is an early event in cerebral ischemia and contributes to the development of cerebral small vessel disease (CSVD). A common rodent model of CSVD is permanent bilateral common carotid artery occlusion in the rat. This model was used to study several aspects of the progression of CSVD including the timecourse of blood

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27

Heye, Anna Kathrin. "Measurement of subtle blood-brain barrier disruption in cerebral small vessel disease using dynamic contrast-enhanced magnetic resonance imaging." Thesis, University of Edinburgh, 2016. http://hdl.handle.net/1842/22929.

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Cerebral small vessel disease (SVD) is a common cause of strokes and dementia. The pathogenesis of SVD is poorly understood, but imaging and biochemical investigations suggest that subtle blood-brain barrier (BBB) leakage may contribute to tissue damage. The most widely-used imaging method for assessing BBB integrity and other microvascular properties is dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). DCE-MRI has primarily been applied in situations where contrast uptake in tissue is typically large and rapid (e.g. neuro-oncology); the optimal approach for quantifying BBB integ

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28

Gregoire, S. M. F. "Cerebral microbleeds as a marker of small vessel disease : new insights from neuro-imaging and clinical studies in stroke patients." Thesis, University College London (University of London), 2014. http://discovery.ucl.ac.uk/1437813/.

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Introduction: A portfolio of studies is presented aimed at understanding the clinical and pathophysiological significance of cerebral microbleeds (CMBs) in stroke patients. CMBs are the radiological marker of microscopic haemosiderin deposits on iron-sensitiveMRI sequences (mainly gradient-recalled echo [GRE] T2* MRI). They are common in patients with cerebrovascular disease and are hypothesised to be a biomarker for brain small vessel diseases, including hypertensive arteriopathy and cerebral amyloid angiopathy (CAA). Important questions relating to CMBs include their use as a prognostic mark

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29

Khallout, Karim. "Cerebral hypoperfusion in the rat and its consequences." Thesis, University of Edinburgh, 2013. http://hdl.handle.net/1842/8064.

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Vascular, especially cerebrovascular, dysfunction may be a critical factor in ageing and dementia. Cerebrovascular impairment due to risk factors such as ageing, stroke, smoking, diabetes and cerebral hypoperfusion has a deterious impact on the normal supply of basic nutrients such as oxygen and glucose to the brain; their absence leads inevitably to neuronal death. The cerebral white matter lesions found in most forms of dementia are reportedly the result of chronic cerebral hypoperfusion. However the temporal and spatial evolution of damage remains unclear. Furthermore, any decrease in the i

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Zeestraten, Eva Anna. "Investigating mechanisms of cognitive decline in patients with cerebral small vessel disease using a combination of neuropsychology and advanced MRI techniques." Thesis, St George's, University of London, 2016. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.719395.

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Aims: To investigate the potential of neuro imaging parameters, including those derived from diffusion tensor imaging (DTI), as surrogate markers of cerebral small vessel disease (SVD), by determining their sensitivity to SVD progression and relationship to cognitive impairment. Methods: A group of 121 patients with symptomatic SVD were assessed on a range of neuropsychological tests and multimodal magnetic resonance imaging (MRI) techniques in the prospective St George’s Cognition And Neuroimaging in Stroke study. MRI was acquired annually for 3 years to evaluate brain volume, lacune and cere

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Williams, Owen A. "The application of a diffusion tensor image segmentation technique in healthy ageing and cerebral small vessel disease : microstructural changes in the cerebrum related to cognitive decline." Thesis, St George's, University of London, 2016. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.719394.

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Brain changes and cognitive decline are observed in healthy ageing and cerebral small vessel disease (SVD), an age-related disease. This thesis describes the optimisation and application of a diffusion tensor image segmentation technique (DSEG) to measure microstructural changes in healthy ageing and SVD in order to predict cognitive decline and dementia risk. Neuropsychological and magnetic resonance imaging data were collected in two prospective cohorts. 112 healthy ageing participants (aged 50-90), tested up to four years. 120 SVD patients (aged 43-89) tested annually for MR! and neuropsych

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Verdura, Edgard. "Familial Cerebral Small Vessel Diseases of unknown etiology : a high throughput approach towards a better understanding of pathophysiological mechanisms." Thesis, Sorbonne Paris Cité, 2016. http://www.theses.fr/2016USPCC264.

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Les maladies des petites artères cérébrales sont un groupe hétérogène de maladies qui affectent les petites artères, artérioles, veines et/ou capillaires du cerveau. La plupart des patients sont des cas sporadiques, mais plusieurs formes héréditaires ont été identifiées.Toutefois, 15 % seulement des patients atteints d’une cSVD familiale sont porteurs d’une mutation dans l’un de ces gènes, suggérant l’implication d’autres gènes. Dans cette thèse, nous avons montré que des mutations hétérozygotes du gène HTRA1 étaient responsables d’environ 5 % des cSVD familiales. L’analyse fonctionnelle de ce

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Dunn, Paul J. "Identifying new genes and genetic factors causative of CADASIL and related stroke and dementia disorders." Thesis, Queensland University of Technology, 2022. https://eprints.qut.edu.au/229972/1/Paul_Dunn_Thesis.pdf.

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CADASIL is a rare and severe neurological disease which causes recurrent strokes, dementia, and migraines. Mutations in the NOTCH3 gene are known to cause CADASIL, however, only ~20% of patients with a clinical presentation (phenotype) of CADASIL have a genetic diagnosis. By completing whole exome sequencing, bioinformatics and statistical investigations, other genes were investigated which may be causative of CADASIL or CADASIL symptoms. This work identified several genes and genetic factors which may be causing or contributing to new variations of CADASIL and provided novel insights into the

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34

Raposo, Nicolas. "Apport des nouveaux biomarqueurs sur la physiopathologie, le diagnostic et le pronostic de l'angiopathie amyloïde cérébrale." Thesis, Toulouse 3, 2019. http://www.theses.fr/2019TOU30340.

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L'angiopathie amyloïde cérébrale (AAC) sporadique est une microangiopathie cérébrale, dont l'intérêt auprès des cliniciens et des chercheurs est grandissant. L'AAC est fréquente chez les sujets âgés et constitue une cause majeure et croissante d'hémorragie intracérébrale et de démence. Des avancées importantes ont été réalisées ces dernières années dans ce champ de recherche, permettant d'identifier de nouveaux biomarqueurs de la maladie, grâce aux progrès réalisés en neuroimagerie structurelle, fonctionnelle et moléculaire. Des thérapies anti-amyloïdes sont en cours de développement et des es

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Caro, Ilana. "Caractérisation de la signature moléculaire de la maladie des petites artères cérébrales occultes par l'étude de biomarqueurs multi-omiques." Electronic Thesis or Diss., Bordeaux, 2024. http://www.theses.fr/2024BORD0453.

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La maladie des petits vaisseaux cérébraux (MPVC) regroupe des processus pathologiques affectant les petits vaisseaux cérébraux (artérioles, capillaires, etc.), détectables en imagerie cérébrale par résonance magnétique (IRM) et dont la prévalence augmente avec l’âge. La MPVC constitue un contributeur vasculaire majeur au déclin cognitif et au risque de démence, et augmente significativement le risque d'accident vasculaire cérébral (AVC). Elle résulte de facteurs génétiques et environnementaux complexes. Bien que plus de 70 loci génétiques aient été associés à la MPVC, les mécanismes moléculair

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Elyas, S. P. "Differences in vascular function between small vessel disease (SVD) stroke and atherosclerotic large vessel (LVD) stroke." Thesis, Exeter and Plymouth Peninsula Medical School, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.700492.

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Fujita, Youshi. "Cilostazol alleviates cerebral small-vessel pathology and white-matter lesions in stroke-prone spontaneously hypertensive rats." Kyoto University, 2009. http://hdl.handle.net/2433/124276.

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Wilson, D. R. "Clinical relevance of neuroimaging biomarkers of small vessel disease in relation to intracranial haemorrhage." Thesis, University College London (University of London), 2018. http://discovery.ucl.ac.uk/10053154/.

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Introduction: Small vessel disease is the underlying cause of most spontaneous (non-traumatic) ICH. Cerebral imaging markers of small vessel disease, particularly cerebral microbleeds (CMBs) and white matter hyperintensities of presumed vascular origin (WMH) offer clinicians and researchers an opportunity to further understand the pathogenesis and risk of ICH in patients with stroke. In this thesis I present a portfolio of studies aimed to show the clinical relevance of neuroimaging biomarkers of small vessel disease in relation to intracerebral haemorrhage (ICH). Methods: I ascertained patien

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Patel, Bhavini. "Searching for surrogate markers of cognitive impairment in small vessel disease: a magnetic resonance imaging and blood biomarker study." Thesis, St George's, University of London, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.617005.

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Cerebral small vessel disease (SVD) is a chronic disease of the small cerebral blood vessels and a common cause of dementia. Surrogate markers for cognitive impairment are required for future treatment trials. Patients with SVD have similar risk factors and MRI features as Alzheimer's disease. Blood biomarkers would be useful for diagnostic and prognostic purposes. St George's Cognition and Neuroimaging Study (SCANS) is a longitudinal study investigating the potential of MRI as a surrogate marker for cognitive impairment. This report examines the baseline data from SCANS. 121 patients with lac

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Saba, Yasaman. "Déterminants génétiques des marqueurs IRM du vieillissement vasculaire cérébral." Electronic Thesis or Diss., Bordeaux, 2024. http://www.theses.fr/2024BORD0466.

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Au cours des dernières années l’espérance de vie accrue a conduit à une augmentation majeure du nombre de nouveaux patients atteints de maladies neurologiques communes, notamment AVC et démence. Des preuves croissantes suggèrent que des déterminants précoces tout au long de la vie, y compris des facteurs génétiques, jouent un rôle crucial dans l'apparition de ces maladies. La maladie des petits vaisseaux cérébraux (MPVC) est une cause majeure d'AVC, de déclin cognitif et de démence. La MPVC est le plus souvent « occulte », détectable en imagerie cérébrale en l'absence de manifestations cliniqu

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Backhouse, Ellen Victoria. "Early life risk factors for cerebrovascular disease and depressive symptoms in later life." Thesis, University of Edinburgh, 2018. http://hdl.handle.net/1842/33184.

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Cerebrovascular disease (CVD) can result in cerebral small vessel disease (cSVD) and structural brain changes such as decreased cortical volume, brain atrophy and cerebral infarcts which are major causes of stroke and dementia. CVD is also associated with increased depression and depressive symptoms in later life. Midlife vascular disease and adult socioeconomic status (SES) are well established risk factors but less is known about the effect of factors from earlier in life on CVD and depressive symptoms in later life. A series of systematic reviews of current literature examining early life f

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Bailey, Emma Louise. "Pathophysiology of lacunar stroke : ischaemic stroke or blood brain barrier dysfunction?" Thesis, University of Edinburgh, 2012. http://hdl.handle.net/1842/6529.

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Lacunar strokes account for approximately a quarter of all ischaemic strokes and traditionally are thought to result from occlusion of a small deep perforating arteriole in the brain. Lacunar infarcts can be up to 2cm in diameter and are found in deep brain structures such as the thalamus and internal capsule. Despite their prevalence and specific accompanying clinical syndromes, the cause of lacunar stroke and its associated vascular pathology remain unclear. Many hypotheses as to the cause exist, which fall broadly into two categories; firstly, a direct occlusion via emboli or thrombus usual

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Du, Plooy Jeanette Noel. "Comparing platelet function and ultrastructure in smoking and thrombo-embolic ischemic stroke." Diss., University of Pretoria, 2013. http://hdl.handle.net/2263/33160.

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Stroke is serious neurological disease and is a major cause of death as well as disability throughout the globe. Stroke has a complex pathophysiology that involves inflammatory pathways, excitotoxicity mechanisms, oxidative damage, apoptosis, ionic imbalances, angiogenesis and neuroprotection. 85% of strokes are ischemic and occurs when a cerebral vessel, or any vessel supplying the brain, narrows or loses pressure resulting in subsequent brain ischemia and infarction downstream to the site of obstruction depriving tissues of vital oxygen and nutrients. This may be caused by either atheroscle

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Borra, Davide. "Sviluppo ed applicazione di reti neurali convoluzionali con dati di neuroimaging." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2018.

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La malattia di Alzheimer (AD) è un disordine neurodegenerativo che rappresenta la forma più comune di demenza negli adulti sopra i 65 anni, mentre la compromissione cognitiva lieve (MCI) è una condizione che in alcuni casi può rappresentare una fase prodromica della malattia di Alzheimer, mentre in altri, è comune in pazienti con la malattia dei piccoli vasi cerebrali (SVD). In questo elaborato sono state sviluppate due reti neurali convoluzionali 2-D, NeuroNet-1 e NeuroNet-2 (o NeuroNet), ed applicate alla classificazione a 2 vie di: a) MCI con SVD (40 pazienti in totale) con dati di diffusio

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Israelsson, Larsen Hanna. "Comorbidity and vascular risk factors associated with idiopathic normal pressure hydrocephalus : the INPH-CRasH Study." Doctoral thesis, Umeå universitet, Institutionen för farmakologi och klinisk neurovetenskap, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-120175.

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Idiopathic normal pressure hydrocephalus (INPH) is a dementia treatable by insertion of a cerebrospinal fluid shunt. It has been suggested that INPH has similar pathophysiological mechanisms as cerebrovascular disease, but the vascular risk factor (VRF) profile of INPH patients has not been assessed using a modern epidemiological approach. The cognitive symptoms of INPH resemble the symptoms of depression, but the prevalence of depression among INPH patients is unknown. In addition, few studies investigate the impact of shunting on the quality of life (QoL), and no study has investigated the i

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Haddad, Iman. "Caractérisation protéomique du matrisome des maladies des petits vaisseaux cérébraux par spectrométrie de masse." Thesis, Université Paris sciences et lettres, 2020. http://www.theses.fr/2020UPSLS026.

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Les maladies des petits vaisseaux cérébraux sont responsables de lésions de la substance blanche du cerveau et d'infarctus cérébrauxprofonds multiples. C'est un ensemble de processus pathologiques, qui affectent les petites artères, les artérioles, veinules oucapillaires cérébraux de moins de 400µm. Le matrisome cérébrovasculaire semble être une voie pathologique convergente entre lesdifférentes maladies des petits vaisseaux de type génétique et de type sporadique. La diversité structurale et physico-chimique desprotéines du matrisome rend cependant leur analyse particulièrement délicate. En e

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Lémeret, Sabrina. "Etude de la relation entre le métabolisme lipidique et les marqueurs de vieillissement cérébral en imagerie par résonance magnétique." Thesis, Bordeaux, 2016. http://www.theses.fr/2016BORD0063.

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L’augmentation de la longévité et une meilleure prise en charge des maladies cardiovasculaires entraînent un accroissement de la fréquence des maladies liées au vieillissement cérébral, les accidents vasculaires cérébraux (AVC) et la démence étant les plus fréquents. Les marqueurs IRM de vieillissement cérébrovasculaire (hypersignaux de la substance blanche [HSB], infarctus silencieux, microhémorragies) sont de forts prédicteurs d’AVC et de démence, très fréquents en population générale âgée et facilement mesurables. Nous avons étudié l’association entre des composantes du métabolisme lipidiqu

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Fouillade, Charles. "Voie de signalisation Notch3 dans les artères cérébrales." Thesis, Paris 5, 2012. http://www.theses.fr/2012PA05T043.

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Le gène Notch3 code pour un récepteur transmembranaire hétérodimérique exprimé principalement dans les cellules musculaires lisses des petites artères. Les travaux de ces dernières années ont montré que le récepteur Notch3 joue un rôle clé dans la physiologie et la pathologie des petites artères. Chez la souris, Notch3 est requis pour l’intégrité structurale et fonctionnelle des artères de résistance en contrôlant l’identité artérielle, la maturation postnatale des cellules musculaires lisses et le tonus myogénique des artères de résistance. Chez l’Homme, les maladies des petites artères céréb

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"Cerebral Small Vessel Disease and Cognitive Impairment." 2015. http://repository.lib.cuhk.edu.hk/en/item/cuhk-1292578.

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McMurtray, Aaron. "Small vessel vascular disease in HIV infection." Thesis, 2007. http://hdl.handle.net/10125/20430.

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