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Journal articles on the topic 'Cervical cancer recurrence'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

van den Tillaart, Sabrina A. H. M., Annelies Schoneveld, Inge T. Peters, et al. "Abdominal Scar Recurrences of Cervical Cancer: Incidence and Characteristics: A Case-Control Study." International Journal of Gynecologic Cancer 20, no. 6 (2010): 1031–40. http://dx.doi.org/10.1111/igc.0b013e3181db5153.

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Background:Tumor recurrence in the surgical scar after radical hysterectomy for cervical cancer has been reported, but the incidence is unknown. Facts about patient and tumor characteristics and follow-up are lacking. The objective of this study was to analyze the incidence and characteristics of cervical cancer scar recurrences.Methods:All patients who were surgically treated for cervical cancer in our center between 1984 and 2007 were reviewed for scar recurrences. For each case, 5 random controls were selected. Clinical characteristics were compared between the cases and controls.Results:El

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Gaikwad, Sujata. "The Scenario of Recurrence of Cervical Cancer by Epigenetics." International Journal for Research in Applied Science and Engineering Technology 11, no. 12 (2023): 129–40. http://dx.doi.org/10.22214/ijraset.2023.57250.

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Abstract: Epigenetic changes happen all the time during life, however, some differences are responsible for specific diseases. One such disease is cancer; nevertheless, a cancer recurrence can be exceedingly lethal and hasten the demise process. Epigenetic changes have the power to completely rule out all current modalities of treatment and have a rapid and substantial impact on the recurrence of cancer. Research indicates that recurrences may occur in up to 70% of individuals with stage III to IVB of cervical cancer. Even with extensive therapy, the 5-year overall survival (OS) rate for recur

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Dzhurayev, Mirzhalol Dekhkanovich, Khilola Ubayduldayevna Ortikova, Mehriniso Rakhmonovna Oripova, and Nodir Mahammatkulovich Rakhimov. "Key Priorities For Immunohistochemical Testing In Predicting Cervical Cancer Recurrence." American Journal of Medical Sciences and Pharmaceutical Research 03, no. 06 (2021): 87–93. http://dx.doi.org/10.37547/tajmspr/volume03issue06-14.

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Cervical cancer is an urgent problem due to its high morbidity, its growth tendency in women of reproductive age, and late presentation. As a result of insufficiently effective surgical and/or radiation treatment of the primary tumor, local recurrences occur in 10-40% of treated patients, and distant metastases in 35% of patients [10]. The first place according to the frequency of distant metastasis in RCC patients is occupied by para-aortic lymph nodes (31.2%), the second - lungs (16.1%), the third - bones (12.9%) [9]. Treatment of recurrent and generalized cervical cancer is a complex and un

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Ubaydullayevna, Ortikova Hilola, Esankulova Bustonoy Sobirovna, and Musayev Mexroj Bakhtiyorovich. "PREDICTION AND STUDY OF THE OCCURRENCE OF CERVICAL CANCER RECURRENCE." International Journal of Medical Sciences And Clinical Research 03, no. 04 (2023): 121–24. http://dx.doi.org/10.37547/ijmscr/volume03issue04-19.

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Cervical cancer has been found to have increased morbidity and mortality in women around the world. Despite complex treatment according to stratification, the risk of relapse is observed in up to 40% of patients Purpose of the study: - Improving the result of early diagnosis of recurrence of cervical cancer stump after complex treatment, by determining the value of the immune response by immunohistochemical markers in combination with the results of complex research methods Materials and methods: - The basis of the research work was a retrospective analysis of the results of the examination an

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Mourton, S. M., Y. Sonoda, N. R. Abu-Rustum, B. H. Bochner, R. R. Barakat, and D. S. Chi. "Resection of recurrent cervical cancer after total pelvic exenteration." International Journal of Gynecologic Cancer 17, no. 1 (2007): 137–40. http://dx.doi.org/10.1111/j.1525-1438.2007.00807.x.

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The objective of this study was to describe the management of patients with recurrent cervical cancer after total pelvic exenteration (TPE). We reviewed the records of patients who underwent TPE for recurrent cervical cancer between June 1992 and December 2003 and subsequently developed recurrent disease. Thirty-seven patients underwent TPE during the study period, and 25 (68%) subsequently developed recurrence proven by radiographic and/or biopsy studies. Recurrence sites included pelvic (12), inguinal (5), retroperitoneal (5), hepatic (4), vulva (2), perineum (1), transposed ovary (1), and l

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Atjimakul, Thiti, and Jitti Hanprasertpong. "Clinical Outcomes and Their Prognostic Factors among Cervical Cancer Patients with Bone Recurrence." Obstetrics and Gynecology International 2022 (September 10, 2022): 1–6. http://dx.doi.org/10.1155/2022/3446293.

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Background. Bone recurrence occurs in 0.75%-8% of cervical cancer patients after primary treatment. Only a few previous studies have reported on survival times associated with prognostic factors for bone recurrent cervical cancer. This study aimed to evaluate the oncological outcomes and their predictors among cervical cancer patients with bone recurrence. Methods. The medical records of cervical cancer patients with bone recurrence who received primary treatment at Songklanagarind Hospital from January 2002 to December 2017 were retrospectively reviewed. Prognostic factors were identified usi

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Tazhibayeva, K., A. Sadykova, D. Tasboltaeva, A. Ormanov, and G. Kaldygozova. "Ways to improve the diagnostics and detection of cervical cancer development and recurrence risk." Oncologia i radiologia Kazakhstana 62, no. 4 (2021): 24–27. http://dx.doi.org/10.52532/2663-4864-2021-4-62-24-27.

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Relevance: Cervical cancer is the fourth leading cause of female death and the third most common female cancer worldwide. The purpose of the study was to determine risk factors and time to progression and recurrence in patients with cervical cancer after complex treatment (neoadjuvant chemotherapy + radical hysterectomy + combined radiation therapy). Materials and methods: This retrospective study involved female patients with stage IB-IIA cervical cancer registered at Shymkent city oncological dispensary in 2011-2021 (n=883). All patients underwent radical hysterectomy with pelvic

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8

Musacchio, Michael J., Anthony W. Kim, Joseph D. Vijungco, and Richard A. Prinz. "Greater Local Recurrence Occurs with “Berry Picking” than Neck Dissection in Thyroid Cancer." American Surgeon 69, no. 3 (2003): 191–97. http://dx.doi.org/10.1177/000313480306900303.

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Managing cervical lymph node metastases in well-differentiated thyroid cancer with either “berry picking” (BP) or anatomic neck dissection (AND) has not been shown to alter survival. Nevertheless local control of thyroid cancer is important. The purpose of this study is to determine whether the local recurrence rate of well-differentiated thyroid cancer is equivalent with BP versus AND. A retrospective analysis revealed 41 patients with well-differentiated thyroid cancer and cervical node metastases seen by a single surgeon from 1985 to 2002. A total of 83 initial and repeat neck operations we

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Brown, A. K., S. Gillis, C. Deuel, C. Angel, C. Glantz, and B. Dubeshter. "Abnormal cervical cytology: a risk factor for endometrial cancer recurrence." International Journal of Gynecologic Cancer 15, no. 3 (2005): 517–22. http://dx.doi.org/10.1136/ijgc-00009577-200505000-00017.

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The objective of this study was to evaluate the relationship between cervical cytology, histologic type, and risk of endometrial cancer recurrence. We performed a retrospective study of patients undergoing surgery for endometrial carcinoma. Risk factors for recurrence including histology, tumor grade, nodal status, myometrial invasion, peritoneal washings, stage, and cervical cytology were assessed. Abnormal cervical cytology was defined as the presence of any endometrial cells on Pap smear. Papillary serous and clear cell carcinomas were considered high-risk histologies. Univariate and multiv

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Moutardier, V., G. Houvenaeghel, M. Martino, et al. "Surgical resection of locally recurrent cervical cancer: a single institutional 70 patient series." International Journal of Gynecologic Cancer 14, no. 5 (2004): 846–51. http://dx.doi.org/10.1136/ijgc-00009577-200409000-00016.

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Pelvic recurrence of cervical cancer is a life-threatening situation and only local control can provide hope for remission. The aim of this study was to evaluate the role of surgery in the treatment of cervical cancer recurrence. This retrospective study analyzed a series of 70 patients who underwent resection of cervix locoregional recurrence. Thirteen patients had palliative salvage surgery for pelvic complications. Twenty-nine resections were considered as curative. Fifty recurrences required pelvic exenterations. The hospital mortality rate was 9% and the morbidity rate was 44%. Overall 5-

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Zouridis, Andreas, Kianoush Zarrindej, Joshua Rencher, et al. "The Prognostic Characteristics and Recurrence Patterns of High Grade Endometrioid Endometrial Cancer: A Large Retrospective Analysis of a Tertiary Center." Journal of Clinical Medicine 12, no. 9 (2023): 3141. http://dx.doi.org/10.3390/jcm12093141.

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High grade endometrioid endometrial cancer (HGEEC) is a heterogeneous group of tumors with unclear prognostic features. The aim of the present study is to evaluate the independent risk factors for recurrence and mortality and to describe the recurrence patterns of HGEEC. Ninety-six consecutive cases of HGEEC treated with primary surgery in a single Tertiary Center were retrospectively reviewed. Clinicopathological and treatment details were recorded, and all patients were closely followed up. Disease-free, overall and cancer-specific survival rates were 83.8%, 77.8% and 83.6%, respectively. Ce

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Maeda, Michihide, Tsuyoshi Hisa, Hiroki Kurahashi, et al. "Surgical Management for Transposed Ovarian Recurrence of Cervical Cancer: A Systematic Review with Our Experience." Current Oncology 29, no. 10 (2022): 7158–70. http://dx.doi.org/10.3390/curroncol29100563.

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In early-stage cervical cancer, ovarian metastasis is relatively rare, and ovarian transposition is often performed during surgery. Although rare, the diagnosis and surgical approach for recurrence at transposed ovaries are challenging. This study focused on the diagnosis and surgical management of transposed ovarian recurrence in cervical cancer patients. A 45-year-old premenopausal woman underwent radical hysterectomy, bilateral salpingectomy, and pelvic lymphadenectomy following postoperative concurrent chemoradiotherapy for stage IB1 cervical cancer. During the initial surgery, the ovary w

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Aimagambetova, Gulzhanat, Gauri Bapayeva, Talshyn Ukybassova, et al. "Risks of Cervical Cancer Recurrence After Fertility-Sparing Surgery and the Role of Human Papillomavirus Infection Types." Journal of Clinical Medicine 13, no. 21 (2024): 6318. http://dx.doi.org/10.3390/jcm13216318.

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Cervical cancer is a largely preventable malignancy of the uterine cervix. The tendencies in cervical cancer morbidity and mortality have remained similar for the past decade, albeit with increasing frequency in low- and middle-income countries (LMICs). Moreover, in the majority of LMICs, cervical cancer is the second most prevalent cancer and the second most common cause of cancer-related death among reproductive-age women. High-risk human papillomavirus (HR-HPV) infections have been proven to be associated with up to 95% of cervical cancer cases, with HPV-16 and HPV-18 types being responsibl

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Song, Yong, Long Nie, and Yu-Ting Zhang. "LncRNAs specifically overexpressed in endocervical adenocarcinoma are associated with an unfavorable recurrence prognosis and the immune response." PeerJ 9 (September 21, 2021): e12116. http://dx.doi.org/10.7717/peerj.12116.

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Background Cervical cancer is the fourth most common gynecological tumor in terms of both the incidence and mortality of females worldwide. Cervical squamous cell carcinoma (CSCC) accounts for 70–80% of cervical cancers, and endocervical adenocarcinoma (EAC) accounts for 20–25%. Unlike CSCC, EAC has worse clinical outcomes and prognosis. In this study, we explored the relationship between various types of long noncoding RNAs (lncRNAs) and pathological types of cervical cancer. Methods RNA sequencing (RNA-Seq) and clinical data from The Cancer Genome Atlas (TCGA) were used in this study. A sing

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Senchukova, Marina A., Elena V. Makarova, Elena I. Shurygina, and Nadezhda N. Volchenko. "Morphological Characteristics and Clinical Significance of Different Types of Tumor Vessels in Patients with Stages I-IIA of Squamous Cervical Cancer." Journal of Oncology 2020 (August 12, 2020): 1–20. http://dx.doi.org/10.1155/2020/3818051.

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The determination of factors associated with progression of cervical cancer is important, both for a recurrence risk assessment and for determining optimal treatment tactics. Previously, we showed the prognostic value of different types of tumor microvessels (MVs) in gastric and breast cancer. The object of this research was to study the morphology and clinical significance of different tumor microvessels in early cervical cancer. A total of 65 archived paraffin blocks of patients with I-IIA stages of squamous cervical cancer were investigated. Samples were stained with Mayer hematoxylin and i

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Chambers, Laura M., Alyssa Herrmann, Chad M. Michener, Cecile A. Ferrando, and Stephanie Ricci. "Vaginal estrogen use for genitourinary symptoms in women with a history of uterine, cervical, or ovarian carcinoma." International Journal of Gynecologic Cancer 30, no. 4 (2020): 515–24. http://dx.doi.org/10.1136/ijgc-2019-001034.

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ObjectiveMenopausal symptoms may adversely affect quality of life and health in women diagnosed with a gynecologic malignancy. The aim of this study was to determine the incidence of adverse outcomes, including cancer recurrence, venous thromboembolism, and secondary malignancies, among patients with a history of endometrial, ovarian, or cervical cancer prescribed vaginal estrogen for genitourinary syndrome of menopause.MethodsA retrospective cohort study was performed including women who were diagnosed with endometrial, ovarian, or cervical cancer from January 1, 1991 to December 31, 2017 and

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Ashrafyan, L. A., T. E. Belokrinitskaya, L. F. Sholokhov, E. V. Kayukova, and V. A. Mudrov. "The recurrences of cervical cancer: Possibilities of molecular prediction." Acta Biomedica Scientifica 7, no. 2 (2022): 34–41. http://dx.doi.org/10.29413/abs.2022-7.2.4.

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The incidence of recurrence of cervical cancer ranges from 10 to 40 %. The 5-year survival rate for patients with recurrent cervical cancer is about 5–15 % against the background of current drug therapy. Clinical and morphological characteristics of the tumor process are known, which are used as markers of an unfavorable prognosis for the development of cervical cancer recurrence. The search for molecular prognostic markers of the course of cervical cancer continues.The aim. To determine the level of immune cycle proteins in patients with cervical cancer 0–IV stages, depending on the occurrenc

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Shumeykina, A. O., A. G. Kedrova, E. A. Zhdanova, A. V. Tarkhov, and S. E. Krasilnikov. "Recurrent high-grade squamous intraepithelial lesion and early-stage cervical cancer (in situ): predictors, long-term treatment outcomes, and opportunities for treatment and prevention." Tumors of female reproductive system 21, no. 1 (2025): 106–15. https://doi.org/10.17650/1994-4098-2025-21-1-106-115.

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Background. The incidence of recurrent cervical dysplasia and early-stage cervical cancer varies between 2 % and 34 % depending on risk factors; thus, treatment and prevention strategies should be chosen individually. Constantly high incidence of cervical cancer and its recurrence necessitates improved preventive measures.Aim. To identify predictors of intracervical recurrence of high-grade squamous intraepithelial lesion (HSIL) and earlystage cervical cancer using multivariate analysis in order to improve treatment strategies for newly diagnosed HSIL patients and patients with recurrent HSIL.

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Serouart, Benjamin, Abel Cordoba, Carlos Martinez-Gomez, et al. "Results of a 20 Year Retrospective Analysis of Early-Stage Cervical Cancer: Should 3 cm Be Considered the New Ariadne’s Thread in Early Cervical Cancer Treatment?" Cancers 15, no. 5 (2023): 1570. http://dx.doi.org/10.3390/cancers15051570.

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(1) This study aims to evaluate the overall survival (OS) and recurrence-free survivals (RFS) and assess disease recurrence of early-stage cervical cancer (ESCC) patients treated with minimally invasive surgery (MIS). (2) This single-center retrospective analysis was performed between January 1999 and December 2018, including all patients managed with MIS for ESCC. (3) All 239 patients included in the study underwent pelvic lymphadenectomy followed by radical hysterectomy without the use of an intrauterine manipulator. Preoperative brachytherapy was performed in 125 patients with tumors measur

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Senthilkumar, Geeitha, Renuka Pitchaimuthu, Seshathiri Dhanasekaran, and Prabu Sankar Panneerselvam. "Integrating Clinical and Transcriptomic Profiles Associated with Vitamin D to Enhance Disease-Free Survival in Cervical Cancer Recurrence Using the CatBoost Algorithm." Diagnostics 15, no. 13 (2025): 1579. https://doi.org/10.3390/diagnostics15131579.

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Background/Objectives: Cervical cancer is a leading cancer-related cause of death among women, with recurrence being a serious clinical issue. Recent evidence demonstrates that long non-coding RNAs (lncRNAs) affect cancer recurrence. This research investigates vitamin D’s regulatory actions in the recurrence of cervical cancer, centering on the involvement of lncRNA. Clinical data on 738 patients shows that greater serum vitamin D levels are linked to reduced recurrence rates and enhanced disease-free survival (DFS). Methods: A transcriptomic analysis of CaSki cervical cancer cells using data

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Ferriss, J. S., W. Brix, M. Henretta, et al. "Extent of cervical involvement in endometrial cancer as a predictor of outcome." Journal of Clinical Oncology 27, no. 15_suppl (2009): e16566-e16566. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.e16566.

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e16566 Background: Endometrial cancer will affect 40,000 women this year. Extent of myometrial invasion and presence of cervical stromal disease are risk-factors for metastasis and recurrence. Uterine cervical involvement is often not known in advance of surgery, and superficial involvement may not be seen at frozen section. The objective of this study was to determine if the extent of cervical invasion is a predictor of outcome. Methods: The institutional cancer registry was searched for cases of stage II uterine cancer from 1996–2006. Inclusion criteria were endometrioid histology and clinic

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Germanova, Anna, Francesco Raspagliesi, Luis Chiva, et al. "Oncological outcome of surgical management in patients with recurrent uterine cancer—a multicenter retrospective cohort study—CEEGOG EX01 Trial." International Journal of Gynecologic Cancer 29, no. 4 (2019): 711–20. http://dx.doi.org/10.1136/ijgc-2019-000292.

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ObjectivesTo assess the survival of patients who have received an operation for recurrent cervical and endometrial cancer and to determine prognostic variables for improved oncologic outcome.MethodsA retrospective multicenter analysis of the medical records of 518 patients with cervical (N = 288) or endometrial cancer (N = 230) who underwent surgery for disease recurrence and who had completed at least 1 year of follow-up.ResultsThe median survival reached 57 months for patients with cervical cancer and 113 months for patients with endometrial cancer after surgical treatment of recurrence (p =

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Guskova, Ekaterina, Oleg Ivanovich Kit, Galina Andreevna Nerodo, et al. "Prognostic factors of cervical cancer recurrence." Journal of Clinical Oncology 34, no. 15_suppl (2016): e17025-e17025. http://dx.doi.org/10.1200/jco.2016.34.15_suppl.e17025.

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Tazhibayeva, K., A. Sadykova, D. Tasboltaeva, A. Ormanov, and G. Kaldygozova. "Ways to improve the diagnostics and detection of cervical cancer development and recurrence risk." Oncologia i radiologia Kazakhstana 62, no. 4 (2021): 24–27. http://dx.doi.org/10.52532/2521-6414-2021-4-62-24-27.

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th and the third most common female cancer worldwide. The purpose of the study was to determine risk factors and time to progression and recurrence in patients with cervical cancer after complex treatment (neoadjuvant chemotherapy + radical hysterectomy + combined radiation therapy). Methods: This retrospective study involved female patients with stage IB-IIA cervical cancer registered at Shymkent city oncological dispensary in 2011- 2021 (n=883). All patients underwent (n=883) radical hysterectomy with pelvic lymph node dissection. The patients

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Law, Kim-Seng, Chung-Er Huang, and Sheng-Wen Chen. "Detection of Circulating Tumor Cell-Related Markers in Gynecologic Cancer Using Microfluidic Devices: A Pilot Study." International Journal of Molecular Sciences 24, no. 3 (2023): 2300. http://dx.doi.org/10.3390/ijms24032300.

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The detection of circulating tumor cells (CTCs) is an emerging strategy for the early detection, prognostication, and identification of recurrent cancer. The clinical utility of CTC detection has been established, but few studies have employed this strategy for the detection of gynecologic cancers. Here, we present a novel, biochip-based microfluidic device for the detection of CTCs in gynecologic cancers. The study cohort included three patients with cervical cancer, eight with endometrial cancer, two with ovarian cancer, two with breast cancer, and one with vaginal small cell carcinoma. Four

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van der Velden, Jacobus, Constantijne H. Mom, Luc van Lonkhuijzen, Ming Y. Tjiong, Henrike Westerveld, and Guus Fons. "Analysis of isolated loco-regional recurrence rate in intermediate risk early cervical cancer after a type C2 radical hysterectomy without adjuvant radiotherapy." International Journal of Gynecologic Cancer 29, no. 5 (2019): 874–78. http://dx.doi.org/10.1136/ijgc-2019-000445.

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BackgroundThe efficacy of adjuvant radiotherapy in patients with intermediate risk early cervical cancer after radical hysterectomy is still under debate. Most guidelines recommend adjuvant radiotherapy, whereas others consider observation a viable option.ObjectiveTo investigate if patients with intermediate risk factors for cervical cancer who underwent radical hysterectomy may benefit from adjuvant radiotherapy.MethodsConsecutive patients with tumor confined to the cervix and intermediate risk factors (according to Sedlis), treated between January 1982 and December 2014 who were observed aft

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Maksimov, A. Yu, M. Yu Timoshkova, E. V. Verenikina, E. A. Lukbanova, and M. M. Kecheryukova. "Evaluation of microRNA profile in cervical epithelium for predicting cervical cancer recurrence." Almanac of Clinical Medicine 48, no. 5 (2020): 333–40. http://dx.doi.org/10.18786/2072-0505-2020-48-054.

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Background: To predict the development and recurrence of cervical cancer (CC), we selected three oncoassociated miRNAs: miRNA-20a, -21, whose overexpression leads to the development of tumors, and -23b, which acts as an oncosuppressor. Aim: To evaluate the microRNA profile in the cervical epithelium for predicting CC recurrence in patients who underwent early treatment.Materials and methods: In the study of the informativeness of expression included 145 patients with T1a1-T2a1N0M0 CC who were followed up for 2 years after treatment. Expression of microR-NA-20a, -21 and -23b was analyzed in tum

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Arifah, Arifah, Rafiq Sulistyo Nugroho, and Alfred J Petrarizky. "Ki-67 AS A PREDICTING FACTOR OF NASOPHARYNGEAL, BREAST, AND CERVICAL CANCER: A LITERATURE REVIEW." International Journal of Radiology and Imaging 3, no. 01 (2024): 26–34. http://dx.doi.org/10.21776//ub.ijri.2024.003.01.5.

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Background: Although the exact role remains unknown, Ki-67 is vital in cell division. Ki-67 is a nuclear nonhistone protein present in all active phases of the cell cycle. It has the potential to predict the prognosis of responsiveness to radiotherapy, chemotherapy, or endocrine therapy, estimate residual risk, and predict recurrence in many types of cancer, including nasopharyngeal cancer (NPC), breast cancer (BC), and cervical cancer (CX), and be a marker for treatment efficacy. We want to review the efficacy of Ki-67 as a predicting factor for three types of cancer, including NPC, breast, a

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Kimmig, Rainer, Antonella Iannaccone, Paul Buderath, Bahriye Aktas, Pauline Wimberger, and Martin Heubner. "Definition of Compartment Based Radical Surgery in Uterine Cancer—Part I: Therapeutic Pelvic and Periaortic Lymphadenectomy by Michael Höckel Translated to Robotic Surgery." ISRN Obstetrics and Gynecology 2013 (March 25, 2013): 1–17. http://dx.doi.org/10.1155/2013/297921.

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Objective. To define compartment based therapeutic pelvic and periaortic lymphadenectomy in cervical and endometrial cancer. Compartment based oncologic surgery appears to be favorable for patients in terms of radicality as well as complication rates, and the same appears to be true for robotic surgery. We describe a method of robotically assisted compartment based lymphadenectomy step by step in uterine cancer and demonstrate feasibility data from 35 patients. Methods. Patients with the diagnosis of endometrial (n=16) or cervical (n=19) cancer were included. Patients were treated by rTMMR (ro

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Mangler, Mandy, Malgorzata Lanowska, Christhardt Köhler, Filiberto Vercellino, Achim Schneider, and Dorothee Speiser. "Pattern of Cancer Recurrence in 320 Patients After Radical Vaginal Trachelectomy." International Journal of Gynecologic Cancer 24, no. 1 (2014): 130–34. http://dx.doi.org/10.1097/igc.0000000000000012.

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ObjectiveThe oncological outcome regarding disease-free survival and overall survival after radical vaginal trachelectomy (RVT) is the same as the rates after radical hysterectomy. We aim to analyze predictive and risk factors and death in patients with cervical cancer undergoing fertility preservation by laparoscopic lymphadenectomy and RVT.MethodsThree hundred twenty patients with cervical cancer underwent RVT between March 1995 and February 2013. In our study, we examined recurrence rates analyzed by risk factors. We classified the presence of lymphovascular space invasion, depth of tumor i

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Okubo, Mitsuru, Tomohiro Itonaga, Tatsuhiko Saito, et al. "Predicting factors for primary cervical cancer recurrence after definitive radiation therapy." BJR|Open 3, no. 1 (2021): 20210050. http://dx.doi.org/10.1259/bjro.20210050.

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Objectives: The study aimed to retrospectively investigate the apparent diffusion coefficient (ADC) of primary cervical cancer to examine the recurrence correlations in patients treated with radiotherapy (RT). Methods: The ADC of 31 patients with cervical cancer treated with RT were analyzed as possible risk factors for recurrence. A receiver operating characteristic (ROC) curve of the mean ADC (ADCmean) for the recurrence was generated to determine the cut-off value that yielded optimal sensitivity and specificity. The patient population was subdivided according to the risk factors for recurr

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Raspagliesi, F., A. Ditto, P. Quattrone, et al. "Prognostic factors in microinvasive cervical squamous cell cancer: long-term results." International Journal of Gynecologic Cancer 15, no. 1 (2005): 88–93. http://dx.doi.org/10.1136/ijgc-00009577-200501000-00014.

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We examined tumor-related pathologic factors and cone-related characteristics to identify parameters related to recurrence in microinvasive squamous cell carcinoma of the cervix treated with conization. This is a retrospective study on 67 consecutive cases of microinvasive carcinoma of the cervix [depth of invasion (DI) <3 mm] treated with conization. The mean follow-up was 121 months (range 72–276 months). Four (6%) invasive recurrences were observed. Presence of lymphvascular space involvement (LVSI) was significantly related with recurrences (P < 0.05). The mean distance between tumor

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Miccò, Maura, Michela Lupinelli, Matteo Mangialardi, Benedetta Gui, and Riccardo Manfredi. "Patterns of Recurrent Disease in Cervical Cancer." Journal of Personalized Medicine 12, no. 5 (2022): 755. http://dx.doi.org/10.3390/jpm12050755.

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Uterine cervical cancer is one of the most common causes of cancer-related deaths among women worldwide. Patients with cervical cancer are at a high risk of pelvic recurrence or distant metastases within the first few years after primary treatment. However, no definitive agreement exists on the best post-treatment surveillance in these patients. Imaging may represent an accurate method of detecting relapse early, right when salvage treatment could be effective. In patients with recurrent cervical cancer, the correct interpretation of imaging may support the surgeon in the proper selection of p

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Linhares Moreira, Ana Sofia, Teresa Margarida Cunha, and Susana Esteves. "Cervical cancer recurrence – can we predict the type of recurrence?" Diagnostic and Interventional Radiology 26, no. 5 (2020): 403–10. http://dx.doi.org/10.5152/dir.2020.19437.

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Oike, Tae, Yoshihito Sekiguchi, Yuya Yoshimoto, et al. "Mutation Analysis of Radioresistant Early-Stage Cervical Cancer." International Journal of Molecular Sciences 23, no. 1 (2021): 51. http://dx.doi.org/10.3390/ijms23010051.

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Radiotherapy is a definitive treatment for early-stage cervical cancer; however, a subset of this disease recurs locally, necessitating establishment of predictive biomarkers and treatment strategies. To address this issue, we performed gene panel-based sequencing of 18 stage IB cervical cancers treated with definitive radiotherapy, including two cases of local recurrence, followed by in vitro and in silico analyses. Simultaneous mutations in KRAS and SMAD4 (KRASmt/SMAD4mt) were detected only in a local recurrence case, indicating potential association of this mutation signature with radioresi

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Kojima, Yuki, Kazuki Sudo, Hiroshi Yoshida, et al. "Abstract 5083: Changes in HER3 expression profiles between initial diagnosis and recurrence in gynecologic cancers." Cancer Research 82, no. 12_Supplement (2022): 5083. http://dx.doi.org/10.1158/1538-7445.am2022-5083.

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Abstract Background: HER3 (ErbB-3) is a member of the epidermal growth factor receptor family of receptor tyrosine kinases, and its overexpression is associated with poorer prognosis in several cancer types. It is unclear whether HER3 expression status changes in tumor tissue at relapse. The purpose of this study is to evaluate changes in HER3 expression between initial diagnosis and recurrence in gynecologic cancers. Methods: This retrospective study included gynecologic cancer patients with matched paired tissues at the time of initial diagnosis and at the time of recurrence between 1999 and

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Oliver-Perez, M. Reyes, Pablo Padilla-Iserte, Octavio Arencibia-Sanchez, et al. "Lymphovascular Space Invasion in Early-Stage Endometrial Cancer (LySEC): Patterns of Recurrence and Predictors. A Multicentre Retrospective Cohort Study of the Spain Gynecologic Oncology Group." Cancers 15, no. 9 (2023): 2612. http://dx.doi.org/10.3390/cancers15092612.

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The main aim is to compare oncological outcomes and patterns of recurrence of patients with early-stage endometrioid endometrial cancer according to lymphovascular space invasion (LVSI) status. The secondary objective is to determine preoperative predictors of LVSI. We performed a multicenter retrospective cohort study. A total of 3546 women diagnosed with postoperative early-stage (FIGO I-II, 2009) endometrioid endometrial cancer were included. Co-primary endpoints were disease-free survival (DFS), overall survival (OS), and pattern of recurrence. Cox proportional hazard models were used for

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Argy, Gabriella, Kartiwa Hadi Nuryanto, and Tantri Hellyanti. "Prognostic Factors of Recurrent Cervical Cancer Stage IA2–IIA2: A Post-Surgical Treatment Analysis." Indonesian Journal of Cancer 18, no. 4 (2024): 427–32. https://doi.org/10.33371/ijoc.v18i4.1141.

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Background: Breast Cervical cancer is the most common female reproductive organ malignancy. Despite the prompt diagnosis and proper management based on the disease’s stage, the recurrent rate remains high, ranging from 18 to 44.3%. Prognostic factor detection may be the first step in reducing recurrent disease. To our knowledge, there are no studies that report the recurrence rate of cervical cancer and the prognostic factors in Indonesia yet. This study aims to report the recurrent rate of cervical cancer stage IA2–IIA2 and the prognostic factors.Methods: This is a retrospective cohort study.

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Amar, Ali, Helma Maria Chedid, Abrão Rapoport, et al. "Update of Assessment of Survival in Head and Neck Cancer after Regional Recurrence." Journal of Oncology 2012 (2012): 1–4. http://dx.doi.org/10.1155/2012/154303.

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Objective. To evaluate site of regional recurrence in patients with squamous cell carcinoma of upper aerodigestive tract after neck dissection and the results of salvage treatment.Methods. 95 patients with regional recurrence as the first manifestation of relapse were selected between 943 patients who underwent neck dissection. We evaluated level and side of recurrence, as well disease control after salvage treatment.Results. Level II was the most frequent site of recurrence. Salvage treatment was performed in 51% of ipsilateral and in 75% of contralateral (nondissected neck) recurrences. Cont

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Wang, Christine, Beverly Lester, Longlong Huang, Shaun Sun, and Jenny J. Ko. "Patient, disease, and survival outcomes for stage IB to stage IV cervical cancer—A population study." Women's Health 19 (January 2023): 174550572311645. http://dx.doi.org/10.1177/17455057231164551.

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Background: Factors that impact recurrence in stages IB to IV include larger tumor, high-risk histology, older age, and lymphovascular invasion (LVI); however, local studies on risk factors for recurrence in British Columbia and our local recurrence patterns have not been well studied. Furthermore, the efficacy of treatment modalities including surgery and chemoradiation in the different stages of cervical cancer have not been clarified in this population. Objectives: The purpose of this study is to determine the disease and treatment characteristics of stages IB to IV cervical cancer which ar

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D’Asta, Marco, Ferdinando Antonio Gulino, Francesco Cannone, Carla Ettore, Giulia Bonanno, and Giuseppe Ettore. "Early Cervical Cancer and Recurrence after Minimally Invasive Surgery without Uterine Manipulator." Surgeries 3, no. 4 (2022): 277–83. http://dx.doi.org/10.3390/surgeries3040030.

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Objective: Worldwide cervical cancer is the fourth most common cancer and is also the fourth leading cause of death among women, after breast cancer, colorectal cancer, and lung cancer. The aim of this study is to investigate the long-term oncological safety of laparoscopic treatment without the use of a uterine manipulator for patients with early stage cervical cancer. Materials and methods: A single-center retrospective study was conducted at the Department of Obstetrics and Gynecology of ARNAS Garibaldi Nesima on patients surgically treated for early cervical cancer from 2014 to 2017. Inclu

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Birara, Malede, Tadesse Urgie, and Abraham Fessehaye Sium. "Locally advanced cervical cancer: Neoadjuvant chemotherapy plus radical surgery an alternative approach to chemo-radiation in a low-income setting: A descriptive study." PLOS ONE 19, no. 10 (2024): e0310457. http://dx.doi.org/10.1371/journal.pone.0310457.

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Objective To describe the treatment outcomes of locally advanced cervical cancer managed with neoadjuvant chemotherapy (NACT) plus radical surgery at a gynecology oncology center in Ethiopia. Methods This was a retrospective descriptive study of management of locally advanced cervical cancer (LACC) at St. Paul’s Hospital Millennium Medical College (Ethiopia) over 5 years. Data were collected by reviewing patient records. Data were analyzed using SPSS version 23. Simple descriptive analysis was employed to analyze clinical, histologic, and treatment outcomes of LACC managed with NACT+ radical s

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Wang, Yu, Tan-Tzu Lo, Lily Wang, et al. "Long-Term Efficacy and Toxicity of Intensity-Modulated Radiotherapy in Bulky Cervical Cancer." International Journal of Environmental Research and Public Health 20, no. 2 (2023): 1161. http://dx.doi.org/10.3390/ijerph20021161.

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Treatment of bulky cervical cancer is associated with both high adverse effects and local recurrence rates with traditional box method radiotherapy. Intensity-modulated radiotherapy (IMRT) has been adopted for the treatment of cervical cancer in order to deliver more precise radiation doses to the target region. We retrospectively enrolled a total of 98 patients with cervical cancer ≥4 cm who completed IMRT and point A-based brachytherapy treatment. The median follow-up time of the cohort was 6.84 years, with the 5-year OS and DFS being 66.33% and 75.12%, respectively. In addition, 7.14% of pa

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Benedetti Panici, Pierluigi, Natalina Manci, Filippo Bellati, et al. "Vaginectomy: A Minimally Invasive Treatment for Cervical Cancer Vaginal Recurrence." International Journal of Gynecologic Cancer 19, no. 9 (2009): 1625–31. http://dx.doi.org/10.1111/igc.0b013e3181a80a0a.

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Objective:Radiotherapy and/or pelvic exenteration represent the treatment of vaginal recurrence, but the prognosis remains unsatisfactory and with long-term complications. We investigated the possible role of vaginectomy for isolated vaginal relapse (IVR) in cervical cancer (CC).Methods:Patients with vaginal CC recurrence were evaluated for surgical treatment consisting in vaginectomy. Data were prospectively collected and analyzed to identify independent prognostic factors.Results:Twenty-nine patients with IVR from CC were enrolled. Early and late complications were observed in 7 (24%) and 6

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Ma, Jing-Hang, Yu Huang, Lu-Yao Liu, and Zhen Feng. "An 8-gene DNA methylation signature predicts the recurrence risk of cervical cancer." Journal of International Medical Research 49, no. 5 (2021): 030006052110184. http://dx.doi.org/10.1177/03000605211018443.

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Objective This study examined the predictive utility of DNA methylation for cervical cancer recurrence. Methods DNA methylation and RNA expression data for patients with cervical cancer were downloaded from The Cancer Genome Atlas. Differentially methylated genes (DMGs) and differentially expressed genes were screened and extracted via correlation analysis. A support vector machine (SVM)-based recurrence prediction model was established using the selected DMGs. Cox regression analysis and receiver operating characteristic curve analysis were used for self-evaluation. The Gene Expression Omnibu

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Huang, Kuan-Ching, Jen-Yu Cheng, Chung-Shih Chen, Chong-Jong Wang, and Eng-Yen Huang. "The Prognostic Role of Magnetic-Resonance-Imaging-Detected Corpus Invasion in Patients with Cervical Carcinoma Who Underwent Definitive or Adjuvant Pelvic Radiotherapy." Cancers 17, no. 9 (2025): 1449. https://doi.org/10.3390/cancers17091449.

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Objectives: In patients undergoing a radical hysterectomy, uterine corpus invasion worsens cervical cancer prognosis. However, the prognostic role of the invasion in locally advanced stages remains elusive. Due to the inadequacy of typical corpus biopsies, corpus invasion is diagnosed using magnetic resonance imaging (MRI). In this study, we investigated the prognostic role of MRI-detected uterine corpus invasion in patients undergoing radiotherapy for cervical cancer. Methods: This retrospective analysis involved 259 patients without extrapelvic metastases, diagnosed with FIGO 2009 stages IB–

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Jung, Jaeyeon, Suhyun Kim, Hyoung-Tae An та Jesang Ko. "α-Actinin-4 regulates cancer stem cell properties and chemoresistance in cervical cancer". Carcinogenesis 41, № 7 (2019): 940–49. http://dx.doi.org/10.1093/carcin/bgz168.

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Abstract Cancer stem cells (CSCs) initiate tumors and possess the properties of self-renewal and differentiation. Since they are responsible for chemoresistance, CSCs are known to be a key factor in cancer recurrence. α-Actinin-4 (ACTN4) is an actin-binding protein that is involved in muscle differentiation and cancer metastasis. It promotes epithelial to mesenchymal transition and cell cycle progression via β-catenin stabilization in cervical cancer. In the present study, we investigated the role of ACTN4 in regulating cancer cell stemness and chemoresistance in cervical cancer. Results from

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Wafaa, Merssetti, El Kachtouhi Aarim Imane, Morchid Soukaina, et al. "LOCALLY ADVANCED CERVICAL CANCER : WHOS AT RISK OF RECURRENCE ?" International Journal of Advanced Research 13, no. 03 (2025): 1349–54. https://doi.org/10.21474/ijar01/20688.

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Background: In Morocco, locally advanced cervical cancer (LACC) remains a significant public health concern, with recurrence rates of 15-50% despite standard treatment involving concurrent chemoradiotherapy (CCRT) and uterovaginal brachytherapy (UVBT). Identifying predictors of recurrence is critical for optimizing therapeutic strategies. Methods: This retrospective cohort study (2018-2022) analyzed 61 LACC patients treated with CCRT at a tertiary center. Data included demographics, tumor characteristics (FIGO 2018 stage, histology, lymph node status), treatment details (UVBT use, treatment du

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Yu, Miao Crystal, R. Marshall Austin, Jeff Lin, et al. "The Role of High-Risk Human Papilloma Virus Testing in the Surveillance of Cervical Cancer After Treatment." Archives of Pathology & Laboratory Medicine 139, no. 11 (2015): 1437–40. http://dx.doi.org/10.5858/arpa.2014-0534-oa.

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Context Cervical cancer affects 12 000 women in the United States annually. However, despite its prevalence, there remains no good methodology to detect its recurrence. Objective To identify the role of cervicovaginal high-risk human papilloma virus (hr-HPV) testing in predicting cervical cancer recurrence. Design This is a retrospective study of patients who underwent hr-HPV testing as part of their routine surveillance for cervical cancer. Standard statistical analyses, including χ2 test and multivariable logistic regression, were performed with IBM SPSS 19.0. Results A total of 133 patients

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Cho, Won Kyung, Young Im Kim, Won Park, Kyungmi Yang, Haeyoung Kim, and Hyejung Cha. "Para-aortic lymph node recurrence after curative radiotherapy for cervical cancer." International Journal of Gynecologic Cancer 29, no. 7 (2019): 1116–20. http://dx.doi.org/10.1136/ijgc-2019-000615.

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ObjectiveThe para-aortic lymph nodes are one of the most common sites in recurrent cervical cancer. However, treatment strategies for para-aortic lymph node recurrence have not yet been established.This study aimed to evaluate the prognostic factors and treatment outcomes in patients with para-aortic lymph node recurrence after curative radiotherapy for cervical cancer.MethodsWe retrospectively reviewed patients who developed para-aortic lymph node recurrence following curative radiation therapy for cervical cancer from January 2001 and December 2014 at the Samsung Medical Center. Prognostic f

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