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Dissertations / Theses on the topic 'CEST imaging'

Author: Grafiati

Published: 7 July 2024

Last updated: 31 July 2025

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1

Truong, Yen Janette. "Discovery of Signal Suppression by N-hydroxy Piperidine to Enable Activity-based Sensing by Chemical Exchange Saturation Transfer Magnetic Resonance Imaging." Thesis, Université d'Ottawa / University of Ottawa, 2020. http://hdl.handle.net/10393/41091.

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Fluorescent probes are useful tools for studying chemical biology, available in a wide variety of colours and applicable to different biochemical processes. One of their hallmarks is the ability to tune their chemistry and allow them to selectively “turn on” in response to different biomolecular targets of interest. However, fluorescence is largely limited by shallow tissue depth of penetration. Magnetic resonance imaging (MRI) can overcome the depth of penetration limitations to better map these biochemical processes and mechanisms with contrast agents. Chemical exchange saturation transfer (

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2

Meißner, Jan-Eric [Verfasser], and Peter [Akademischer Betreuer] Bachert. "Quantitative pulsed CEST MR imaging / Jan-Eric Meißner ; Betreuer: Peter Bachert." Heidelberg : Universitätsbibliothek Heidelberg, 2017. http://d-nb.info/118098594X/34.

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3

Sinharay, Sanhita. "Development and Application of CatalyCEST MRI Contrast Agents for the Study of Enzyme Activities in Tumor Models." Diss., The University of Arizona, 2016. http://hdl.handle.net/10150/612945.

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The in vivo detection of enzyme activity is a significant biomarker in tumorigenesis. Assessment of enzyme activity relative to enzyme concentration can serve as quite an accurate measurement of several disease states. Chemical Exchange Saturation Transfer (CEST) MRI is a non-invasive imaging technique that can be used to evaluate enzyme activity. Compared to other contrast agents CEST MRI agents have a slower chemical exchange rate and thus have greater specificity for detecting the intended biomarker. Chapter 1 provides an overview of the advances made in the field of molecular imaging for d

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4

Chen, Liu Qi. "Development and Application of AcidoCEST MRI for Evaluating Tumor Acidosis in Pre-Clinical Cancer Models." Diss., The University of Arizona, 2014. http://hdl.handle.net/10150/323450.

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Tumor acidosis is an important biomarker in cancer. We have developed a noninvasive imaging method, termed acidosis Chemical Exchange Saturation Transfer (acidoCEST) MRI to measure extracellular pH (pHe) in the tumor microenvironment. Chapter 1 introduces the importance of measuring tumor acidosis and presents various imaging modalities and their shortcoming to measure pHe. Chapter 2 describes the optimization of acidoCEST MRI for in vivo pHe measurement. The acidoCEST MRI protocol consists of a CEST-FISP acquisition and Lorentzian line shape fittings. We determined the optimal saturation time

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5

Sheth, Vipul Ravindra. "A CEST MRI METHOD TO MEASURE pH." Case Western Reserve University School of Graduate Studies / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=case1290287480.

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6

Hingorani, Dina Vinoo. "Developing Responsive MRI Contrast Agents to Study Tumor Biology." Diss., The University of Arizona, 2014. http://hdl.handle.net/10150/333481.

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Enzymes are important biomarkers for determining tumor growth and progression. We have developed two molecules to image enzyme response by catalyCEST MRI. This technology allows for non-invasive detection of enzymes. A background of importance of measuring enzyme activity and MRI agents developed for this purpose have been covered in Chapter 1. We have synthesized a responsive paramagnetic Chemical Exchange Saturation Transfer (CEST) agent, called Tm-DO3A-cadaverine. This contrast agents has been successfully cross-linked to the protein albumin by the enzyme transglutaminase leading to the ap

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7

Daryaei, Iman, and Iman Daryaei. "Study, Evaluation, and Applications of MRI Contrast Agents that Work Based on CEST and T2-EX Mechanisms." Diss., The University of Arizona, 2017. http://hdl.handle.net/10150/625366.

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MRI is a powerful imaging method that offers several advantages including non-ionizing radiation, significant depth of penetration, and great spatial resolution. Current demand for precision medicine and the movement toward personalized medicine have encouraged researchers in the field of medical imaging to develop MRI-based techniques. Various techniques are now available for molecular imaging by MRI. MRI started by utilizing T1 relaxation properties of molecules but soon after other relaxation mechanisms such as T2 and recently Chemical Exchange Saturation Transfer (CEST) were developed. Eac

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8

Jones, Kyle M., and Kyle M. Jones. "Improving the Accuracy and Precision of Chemical Exchange Saturation Transfer (CEST) MRI." Diss., The University of Arizona, 2016. http://hdl.handle.net/10150/621793.

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Chemical exchange saturation transfer (CEST) MRI has the ability to noninvasively measure endogenous biomarkers and exogenous agents relevant to various diseases and medical conditions. My work has focused on the development of MRI pulse sequences and data analysis methods to more accurately estimate endogenous and exogenous CEST contrast measurements at 7 T and 3 T magnetic field strengths. Chapter 1 discusses the various sources of signal that have been measured with CEST MRI in the clinic, the acquisition methods used to acquire these signals, and the data analysis methods used to quantify

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9

Pépin, Jérémy. "Développement de l’imagerie métabolique par IRM-CEST : application à la maladie de Huntington." Thesis, Université Paris-Saclay (ComUE), 2018. http://www.theses.fr/2018SACLS032/document.

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La maladie de Huntington (MH) est une maladie neurodégénérative héréditaire qui affecte le cerveau. Cette maladie est caractérisée par des signes cliniques tels que la dépression, la démence ainsi que des troubles moteurs s’aggravant au fil du temps. Ces déficiences sont dues à une augmentation anormale de la taille des répétitions CAG dans le gène codant la protéine huntingtine. Celle-ci s’accumule dans les cellules cérébrales et entraine leur mort. Des études antérieures ont démontré que le profil métabolique mesuré en spectroscopie RMN ¹H pouvait être altéré chez les patients atteints de ce

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10

Goldsher, Anetta Victoria, and Anetta Victoria Goldsher. "Detection of Enzyme Activity in a Pancreatic Tumor Model Using CatalyCEST Contrast MRI." Thesis, The University of Arizona, 2017. http://hdl.handle.net/10150/625887.

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Detection of enzyme activity has gained popularity in molecular imaging because increased activity of enzymes such as urokinase plasminogen activator (uPA) can serve as biomarkers and assist in cancer diagnosis. Chemical exchange saturation transfer (CEST) Magnetic Resonance Imaging (MRI) is a non-invasive technique that can be utilized to detect enzyme activity; however, CEST MRI is not the only technique that can assess enzyme activity. Chapter 1 provides an overview of various imaging modalities that have been used to detect enzyme activity in vivo. Advances made in probe-design are discuss

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11

Lázňovský, Jakub. "Analýza dýchacích cest předčasně narozených dětí na základě MRI a CT dat." Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2020. http://www.nusl.cz/ntk/nusl-413140.

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Předkládaná Diplomová práce se zabývá analýzou a tvorbou modelů dýchacích cest předčasně narozených dětí. Nejprve je položen teoretický základ v oblasti vývoje dýchacího ústrojí a tvorby modelů dýchacích cest. Poté jsou představeny využité zobrazovací modality a popsány metody pro práci s obrazovými daty. Praktická část práce se zabývá vytvořením modelů dýchacích cest tří novorozenců. Všechny tyto modely jsou vytvořeny na základě klinických CT a MRI dat novorozenců narozených ve 30. týdnu gestačního věku. U těchto vytvořených modelů jsou dále analyzovány vybrané parametry související s anatomi

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12

Delebarre, Thaddée. "Development of fast and robust metabolic imaging in humans at high magnetic field." Electronic Thesis or Diss., université Paris-Saclay, 2024. http://www.theses.fr/2024UPAST001.

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L'imagerie par résonance magnétique du transfert de saturation par échange chimique (IRM CEST) représente un outil puissant pour l'étude du métabolisme, offrant une résolution temporelle et spatiale supérieure ainsi qu'une sensibilité accrue par rapport à la spectroscopie par résonance magnétique. L'IRM CEST permet la détection indirecte de certains métabolites grâce à l'interaction entre leurs protons et ceux de l'eau. Le CEST peut cartographier le glucose, le glutamate et la créatine, qui sont des métabolites importants impliqués dans les cancers et les maladies neurodégénératives et musculo

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13

Clark, Daniel James. "Chemical Exchange Saturation Transfer and Quantitative MRI Methods: Applications for Osteoarthritis and Cartilage Injury." The Ohio State University, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=osu1431016691.

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14

Chahid, Bochra. "Développement et caractérisation de nouveaux agents de contraste lipidiques ultrasensibles pour l'imagerie par résonnance magnétique destinés à l'imagerie moléculaire." Thesis, Paris 11, 2012. http://www.theses.fr/2012PA114867/document.

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L’effet des composés paramagnétiques sur le déplacement chimique des protons, c’est-à-dire sur leur fréquence de résonance propre, beaucoup utilisé en RMN conventionnelle, peut également être un outil de contraste en Imagerie par Résonance Magnétique (IRM) pour réaliser des images encodées en fréquence et donc sélectives selon la nature ou l’environnement de l’entité que l’on cherche à révéler. Cette approche fait intervenir le transfert d’aimantation par échange chimique de protons mobiles, en anglais « Chemical Exchange Saturation Transfer » (CEST). Le principe consiste à saturer sélectiveme

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15

Tee, Yee Kai. "Quantitative measurement of pH in stroke using chemical exchange saturation transfer magnetic resonance imaging." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:e5634676-55a5-43ef-92e7-12166f3d6bf0.

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Stroke is one of the leading causes of death and adult disability worldwide. The major therapeutic intervention for acute ischemic stroke is the administration of recombinant tissue plasminogen activator (rtPA) to help to restore blood flow to the brain. This has been shown to increase the survival rate and to reduce the disability of ischemic stroke patients. However, rtPA is associated with intracranial haemorrhage and thus its administration is currently limited to only about 5% of ischemic stroke patients. More advanced imaging techniques can be used to better stratify patients for rtPA tr

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16

Msayib, Yunus. "Quantifying impaired metabolism following acute ischaemic stroke using chemical exchange saturation transfer magnetic resonance imaging." Thesis, University of Oxford, 2017. http://ora.ox.ac.uk/objects/uuid:a98323ce-5998-436d-bca4-09df549cf191.

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In ischaemic stroke a disruption of cerebral blood flow leads to impaired metabolism and the formation of an ischaemic penumbra in which tissue at risk of infarction is sought for clinical intervention. In stroke trials, therapeutic intervention has largely been based on perfusion-weighted measures, but these have not been shown to be good predictors of tissue outcome. The aim of this thesis was to develop analysis techniques for magnetic resonance imaging (MRI) of chemical exchange saturation transfer (CEST) in order to quantify metabolic signals associated with tissue fate in patients with a

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17

Draskovic, Gordana. "Statistiques des estimateurs robustes pour le traitement du signal et des images." Thesis, Université Paris-Saclay (ComUE), 2019. http://www.theses.fr/2019SACLC069.

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Un des défis majeurs en traitement radar consiste à identifier une cible cachée dans un environnement bruité. Pour ce faire, il est nécessaire de caractériser finement les propriétés statistiques du bruit, en particulier sa matrice de covariance. Sous l'hypothèse gaussienne, cette dernière est estimée par la matrice de covariance empirique (SCM) dont le comportement est parfaitement connu. Cependant, dans de nombreuses applications actuelles, tels les systèmes radar modernes à haute résolution par exemple, les données collectées sont de nature hétérogène, et ne peuvent être proprement décrites

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18

Terreaux, Eugénie. "Théorie des Matrices Aléatoires pour l'Imagerie Hyperspectrale." Thesis, Université Paris-Saclay (ComUE), 2018. http://www.theses.fr/2018SACLC091/document.

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La finesse de la résolution spectrale et spatiale des images hyperspectrales en font des données de très grande dimension. C'est également le cas d'autres types de données, où leur taille tend à augmenter pour de plus en plus d'applications. La complexité des données provenant de l'hétérogénéité spectrale et spatiale, de la non gaussianité du bruit et des processus physiques sous-jacents, renforcent la richesse des informations présentes sur une image hyperspectrale. Exploiter ces informations demande alors des outils statistiques adaptés aux grandes données mais aussi à leur nature non gaussi

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19

Icke, Ilknur. "Machine learning applications for measuring pH using CEST MRI." Thesis, 2019. https://hdl.handle.net/2144/38675.

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Non-invasive measurement of pH provides multiple potential benefits in oncology such as better identifying the type of drug that can be more effective in chemotherapy, potentially identifying tumors that are more likely to metastasize and also better assessing the treatment effects. Chemical Exchange Saturation Transfer (CEST) Magnetic Resonance Imaging (MRI) is a versatile non-invasive technique for molecular imaging. AcidoCEST MRI techniques have been developed over the recent years to perform tumor pH measurements by utilizing a contrast agent for which chemical exchange saturation transfe

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20

Lenich, Tobias. "Development and Application of an NMR Metabolic Imaging Technique based on CEST/NOE." 2018. https://ul.qucosa.de/id/qucosa%3A32395.

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For a thorough investigation of metabolic changes in cases of increased activity or disease, a high-resolution imaging modality would be of high-value. Conventional MR-based metabolite mapping techniques suffer from low spatial resolution and poor sensitivity to low concentrated metabolites. In this work, a novel optimization approach for high-resolution metabolic imaging by means of chemical exchange saturation transfer (CEST) and nuclear Overhauser effect (NOE) will be introduced. The general term of saturation transfer comprises CEST, NOE and magnetization transfer (MT). It describes the tr

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21

Holý, Petr. "Detekce neuronální aktivity spojené s funkcí dolních močových cest pomocí funkční magnetické rezonance." Doctoral thesis, 2014. http://www.nusl.cz/ntk/nusl-342239.

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of the thesis Considerable research attention has been paid to the neural regulation of the lower urinary tract (LUT) in past three decades. The aim of this work is mapping of a brain activity by functional magnetic resonance imaging (fMRI) using refined scanning protocol with synchronously performed urodynamics. We aimed to detect neural activity associated with pelvic floor muscle (PF) contractions, filling of urinary bladder and miction. In addition we evaluated using fMRI brain activity associated with urinary bladder filling in patients with a complete spinal cord injury (SCI). We hypothe

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22

Zábrodský, Michal. "Využití speciálních optických metod v diagnostice benigních a maligních slizničních lézí horních cest dýchacích a polykacích." Doctoral thesis, 2019. http://www.nusl.cz/ntk/nusl-405121.

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Optical imaging methods incorporating observation of the mucosal surface of organs with narrowband filtered light are diagnostic tools with a significant development in recent years and have become an integral and inseparable part of the diagnostic process of benign and malignant pathologies of the mucosal surface of various anatomical systems of the human body. Malignant and premalignant lesions of the upper aero-digestive tract (UADT) are no exception. The present work demonstrates the benefits of evaluation of changes in microvascular architecture by narrowband imaging. Its major advantage

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23

Krchová, Tereza. "Responzivní kontrastní látky pro tomografii magnetické rezonance (MRI)." Doctoral thesis, 2017. http://www.nusl.cz/ntk/nusl-357606.

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ABSTRACT This work is focused on the synthesis of a family of new macrocyclic ligands with exchangeable protons on coordinating groups that could potentially serve (after complexation with suitable paramagnetic lanthanide(III) ions) as responsive contrast agents (CAs) for magnetic resonance imaging (MRI). It is expected that measurement of extracellular pH should bring information for tumorous disease diagnoses and/or for suggesting the most efficient treatment. Therefore, our attention was focused on pH-dependent CAs based on a PARAmagnetic Chemical Exchange Saturation Transfer (PARACEST) mec

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24

Jalon, Maria Dolores. "Imagen del Cuchillo, simbolo de cosmovision tragica en el libro el Rayo Que no Cesa, de Miguel Hernandez." Diss., 2002. http://hdl.handle.net/10500/872.

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Summaries in Spanish and English<br>Text in Spanish<br>The aim of this dissertation is to analyse those poems in which the image of the knife, el cuchillo, appears in the collection El rayo que no cesa, by Miguel Hernandez. The poet manifests his all-encompassing tragic view of life by means of this recurring negative symbol. The poetry of Miguel Hernandez is autobiographical: The universal themes of nature, love and death reveal a close link between the course of his life and the evolution of his poetry. El rayo que no cesa is central to the evolution of Hernandez's poetry: it is the pr

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25

Jalón, María Dolores. "La imagen del Cuchillo, símbolo de cosmovisión trágica en el libro el Rayo Que no Cesa, de Miguel Hernández." Diss., 2002. http://hdl.handle.net/10500/872.

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Summaries in Spanish and English<br>Text in Spanish<br>The aim of this dissertation is to analyse those poems in which the image of the knife, el cuchillo, appears in the collection El rayo que no cesa, by Miguel Hernandez. The poet manifests his all-encompassing tragic view of life by means of this recurring negative symbol. The poetry of Miguel Hernandez is autobiographical: The universal themes of nature, love and death reveal a close link between the course of his life and the evolution of his poetry. El rayo que no cesa is central to the evolution of Hernandez's poetry: it is the pr

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