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Journal articles on the topic 'CEST imaging'

Author: Grafiati

Published: 7 July 2024

Last updated: 31 July 2025

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1

Döpfert, Jörg, Moritz Zaiss, Christopher Witte, and Leif Schröder. "Ultrafast CEST imaging." Journal of Magnetic Resonance 243 (June 2014): 47–53. http://dx.doi.org/10.1016/j.jmr.2014.03.008.

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2

Xu, Xiang, Nirbhay N. Yadav, Xiaolei Song, et al. "Screening CEST contrast agents using ultrafast CEST imaging." Journal of Magnetic Resonance 265 (April 2016): 224–29. http://dx.doi.org/10.1016/j.jmr.2016.02.015.

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3

Saito, Shigeyoshi. "5. Advanced Imaging Technology—T1rho—CEST Imaging." Japanese Journal of Radiological Technology 78, no. 1 (2022): 95–100. http://dx.doi.org/10.6009/jjrt.780111.

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4

Kejia Cai, Rongwen Tain, Xiaohong J. Zhou, and Charles E. Ray. "CEST MRI for Molecular Imaging of Brain Metabolites." Current Molecular Imaging 4, no. 2 (2015): 100–108. http://dx.doi.org/10.2174/2211555204666160210232349.

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As a sensitive MRI method, Chemical Exchange Saturation Transfer (CEST) MRI based on endogenous contrast has been increasingly utilized for molecular imaging of various metabolites. Among these applications, the authors have described CEST MRI for molecular imaging of brain metabolites in this review, including brain glutamate, the most abundant excitatory neurotransmitter; creatine, a key molecular of bioenergetics; and myo-inositol, a biomarker of glial cells. Those metabolites conventionally have been quantified with MR spectroscopy methods. Compared to MR spectroscopy, CEST methods typical

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5

Sun, Phillip Zhe. "Quasi–steady‐state CEST (QUASS CEST) solution improves the accuracy of CEST quantification: QUASS CEST MRI‐based omega plot analysis." Magnetic Resonance in Medicine 86, no. 2 (2021): 765–76. http://dx.doi.org/10.1002/mrm.28744.

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6

Sawaya, Reika, Sohei Kuribayashi, Junpei Ueda, and Shigeyoshi Saito. "Evaluating the Cisplatin Dose Dependence of Testicular Dysfunction using Creatine Chemical Exchange Saturation Transfer Imaging." Diagnostics 12, no. 5 (2022): 1046. http://dx.doi.org/10.3390/diagnostics12051046.

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Chemical exchange saturation transfer (CEST) imaging is a non-invasive molecular imaging technique for indirectly measuring low-concentration endogenous metabolites. Conventional CEST has low specificity, owing to the effects of spillover, magnetization transfer (MT), and T1 relaxation, thus necessitating an inverse Z-spectrum analysis. We aimed to investigate the usefulness of inverse Z-spectrum analysis in creatine (Cr)-CEST in mice, by conducting preclinical 7T-magnetic resonance imaging (MRI) and comparing the conventional analysis metric magnetization transfer ratio (MTRconv) with the nov

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Yu, Qin, Zian Yu, Lijiao Yang, and Yue Yuan. "Recent progress on diaCEST MRI for tumor imaging." JUSTC 53, no. 6 (2023): 0601. http://dx.doi.org/10.52396/justc-2023-0027.

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Chemical exchange saturation transfer (CEST) magnetic resonance imaging (MRI) is an advanced imaging method that probes the chemical exchange between bulk water protons and exchangeable solute protons. This chemical exchange decreases the MR signal of water and reveals the distribution and concentration of certain endogenous biomolecules or extrogenous contrast agents in organisms with high sensitivity and spatial resolution. The CEST signal depends not only on the concentration of the CEST contrast agent and external magnetic field but also on the surrounding environments of the contrast agen

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Longo, Dario Livio, Fatima Zzahra Moustaghfir, Alexandre Zerbo, et al. "EXCI-CEST: Exploiting pharmaceutical excipients as MRI-CEST contrast agents for tumor imaging." International Journal of Pharmaceutics 525, no. 1 (2017): 275–81. http://dx.doi.org/10.1016/j.ijpharm.2017.04.040.

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Gao, Tianxin, Chuyue Zou, Yifan Li, Zhenqi Jiang, Xiaoying Tang, and Xiaolei Song. "A Brief History and Future Prospects of CEST MRI in Clinical Non-Brain Tumor Imaging." International Journal of Molecular Sciences 22, no. 21 (2021): 11559. http://dx.doi.org/10.3390/ijms222111559.

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Chemical exchange saturation transfer (CEST) MRI is a promising molecular imaging tool which allows the specific detection of metabolites that contain exchangeable amide, amine, and hydroxyl protons. Decades of development have progressed CEST imaging from an initial concept to a clinical imaging tool that is used to assess tumor metabolism. The first translation efforts involved brain imaging, but this has now progressed to imaging other body tissues. In this review, we summarize studies using CEST MRI to image a range of tumor types, including breast cancer, pelvic tumors, digestive tumors,

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10

Lingl, Julia P., Arthur Wunderlich, Steffen Goerke, et al. "The Value of APTw CEST MRI in Routine Clinical Assessment of Human Brain Tumor Patients at 3T." Diagnostics 12, no. 2 (2022): 490. http://dx.doi.org/10.3390/diagnostics12020490.

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Background. With fast-growing evidence in literature for clinical applications of chemical exchange saturation transfer (CEST) magnetic resonance imaging (MRI), this prospective study aimed at applying amide proton transfer-weighted (APTw) CEST imaging in a clinical setting to assess its diagnostic potential in differentiation of intracranial tumors at 3 tesla (T). Methods. Using the asymmetry magnetization transfer ratio (MTRasym) analysis, CEST signals were quantitatively investigated in the tumor areas and in a similar sized region of the normal-appearing white matter (NAWM) on the contrala

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11

Huang, Jianpan, Zilin Chen, Se-Weon Park, Joseph H. C. Lai, and Kannie W. Y. Chan. "Molecular Imaging of Brain Tumors and Drug Delivery Using CEST MRI: Promises and Challenges." Pharmaceutics 14, no. 2 (2022): 451. http://dx.doi.org/10.3390/pharmaceutics14020451.

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Chemical exchange saturation transfer (CEST) magnetic resonance imaging (MRI) detects molecules in their natural forms in a sensitive and non-invasive manner. This makes it a robust approach to assess brain tumors and related molecular alterations using endogenous molecules, such as proteins/peptides, and drugs approved for clinical use. In this review, we will discuss the promises of CEST MRI in the identification of tumors, tumor grading, detecting molecular alterations related to isocitrate dehydrogenase (IDH) and O-6-methylguanine-DNA methyltransferase (MGMT), assessment of treatment effec

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12

Wang, Chengguang, Guisen Lin, Zhiwei Shen, and Runrun Wang. "Angiopep-2 as an Exogenous Chemical Exchange Saturation Transfer Contrast Agent in Diagnosis of Alzheimer’s Disease." Journal of Healthcare Engineering 2022 (April 5, 2022): 1–7. http://dx.doi.org/10.1155/2022/7480519.

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Background. Chemical exchange saturation transfer (CEST) is a novel imaging modality in clinical practice and scientific research. Angiopep-2 is an artificial peptide that can penetrate blood-brain barrier. The aim of this study was to explore the feasibility of Angiopep-2 serving as an exogenous CEST contrast. Methods. Phantoms of Angiopep-2 with different concentrations were prepared and then scanned using the 7.0T small animal MRI scanner. Different parameters including saturation powers and saturation duration were used to achieve the optimal CEST effect, and the optimal parameters were fi

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13

Koike, Hirofumi, Minoru Morikawa, Hideki Ishimaru, Reiko Ideguchi, Masataka Uetani, and Mitsuharu Miyoshi. "Amide Proton Transfer–Chemical Exchange Saturation Transfer Imaging of Intracranial Brain Tumors and Tumor-Like Lesions: Our Experience and a Review." Diagnostics 13, no. 5 (2023): 914. http://dx.doi.org/10.3390/diagnostics13050914.

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Chemical exchange saturation transfer (CEST) is a molecular magnetic resonance imaging (MRI) method that can generate image contrast based on the proton exchange between labeled protons in solutes and free, bulk water protons. Amide proton transfer (APT) imaging is the most frequently reported amide-proton-based CEST technique. It generates image contrast by reflecting the associations of mobile proteins and peptides resonating at 3.5 ppm downfield from water. Although the origin of the APT signal intensity in tumors is unclear, previous studies have suggested that the APT signal intensity is

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14

Kikuchi, Kazufumi, Keisuke Ishimatsu, Shanrong Zhang, et al. "Presaturation Power Adjusted Pulsed CEST: A Method to Increase Independence of Target CEST Signals." Contrast Media & Molecular Imaging 2018 (2018): 1–11. http://dx.doi.org/10.1155/2018/3141789.

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Chemical exchange saturation transfer (CEST) imaging has been demonstrated to discuss the concentration changes of amide proton, glutamate, creatine, or glucose measured at 3.5, 3.0, 2.0, and 1.0–1.2 ppm. However, these peaks in z-spectra are quite broad and overlap with each other, and thus, the independence of a CEST signal on any specific metabolite is still open to question. Here, we described whether there was interference among the CEST signals and how these CEST signals behave when the power of the presaturation pulse was changed. Based on these results, further experiments were designe

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15

Kortje, Zoe A., and Horacio Bach. "CEST MRI in the Management/Diagnosis of Neuroinfectious Diseases." International Journal of Molecular Sciences 26, no. 12 (2025): 5650. https://doi.org/10.3390/ijms26125650.

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Chemical exchange saturation transfer (CEST) MRI is a novel technique that allows for the specific imaging of certain molecules that contain exchangeable protons. Neuroimaging is a major contributor to diagnosing and monitoring infections of the central nervous system (CNS). This review focuses on summarizing the current literature surrounding the use of CEST MRI imaging in diagnosing, monitoring, and treating CNS infections. BacCEST is a new technique to detect bacterial infection in organs at profound levels. This technique allows for the specific pathogen causing the infection to be underst

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16

Shen, Zhi-wei, Lv-hao Wang, Zhuo-zhi Dai, Gang Xiao, Yin Wu, and Ren-hua Wu. "Chemical Exchange Saturation Transfer (CEST) Imaging of pH." Neuroscience and Biomedical Engineering 1, no. 2 (2014): 111–15. http://dx.doi.org/10.2174/2213385202666140207001055.

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17

Longo, D. "SP-0555 MRI-CEST Imaging of tumor acidosis." Radiotherapy and Oncology 133 (April 2019): S291—S292. http://dx.doi.org/10.1016/s0167-8140(19)30975-2.

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18

Peng, Qiaoli, Yaping Yuan, Huaibin Zhang, et al. "19F CEST imaging probes for metal ion detection." Organic & Biomolecular Chemistry 15, no. 30 (2017): 6441–46. http://dx.doi.org/10.1039/c7ob01068k.

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19

Yuan, Yifan, Yang Yu, Yu Guo, et al. "Noninvasive Delineation of Glioma Infiltration with Combined 7T Chemical Exchange Saturation Transfer Imaging and MR Spectroscopy: A Diagnostic Accuracy Study." Metabolites 12, no. 10 (2022): 901. http://dx.doi.org/10.3390/metabo12100901.

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For precise delineation of glioma extent, amino acid PET is superior to conventional MR imaging. Since metabolic MR sequences such as chemical exchange saturation transfer (CEST) imaging and MR spectroscopy (MRS) were developed, we aimed to evaluate the diagnostic accuracy of combined CEST and MRS to predict glioma infiltration. Eighteen glioma patients of different tumor grades were enrolled in this study; 18F-fluoroethyltyrosine (FET)-PET, amide proton transfer CEST at 7 Tesla(T), MRS and conventional MR at 3T were conducted preoperatively. Multi modalities and their association were evaluat

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20

Wu, Yulun, Tobias C. Wood, Fatemeh Arzanforoosh, et al. "3D APT and NOE CEST-MRI of healthy volunteers and patients with non-enhancing glioma at 3 T." Magnetic Resonance Materials in Physics, Biology and Medicine 35, no. 1 (2022): 63–73. http://dx.doi.org/10.1007/s10334-021-00996-z.

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Abstract Objective Clinical application of chemical exchange saturation transfer (CEST) can be performed with investigation of amide proton transfer (APT) and nuclear Overhauser enhancement (NOE) effects. Here, we investigated APT- and NOE-weighted imaging based on advanced CEST metrics to map tumor heterogeneity of non-enhancing glioma at 3 T. Materials and methods APT- and NOE-weighted maps based on Lorentzian difference (LD) and inverse magnetization transfer ratio (MTRREX) were acquired with a 3D snapshot CEST acquisition at 3 T. Saturation power was investigated first by varying B1 (0.5–2

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21

Li, Yuguo, Hanwei Chen, Jiadi Xu, et al. "CEST theranostics: label-free MR imaging of anticancer drugs." Oncotarget 7, no. 6 (2016): 6369–78. http://dx.doi.org/10.18632/oncotarget.7141.

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22

Dai, Zhuozhi, Jim Ji, Gang Xiao, et al. "Magnetization Transfer Prepared Gradient Echo MRI for CEST Imaging." PLoS ONE 9, no. 11 (2014): e112219. http://dx.doi.org/10.1371/journal.pone.0112219.

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23

Cobb, Jared Guthrie, Ke Li, Jingping Xie, Daniel F. Gochberg, and John C. Gore. "Exchange-mediated contrast in CEST and spin-lock imaging." Magnetic Resonance Imaging 32, no. 1 (2014): 28–40. http://dx.doi.org/10.1016/j.mri.2013.08.002.

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24

Zhang, Shanrong, Robert Trokowski, and A. Dean Sherry. "A Paramagnetic CEST Agent for Imaging Glucose by MRI." Journal of the American Chemical Society 125, no. 50 (2003): 15288–89. http://dx.doi.org/10.1021/ja038345f.

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25

Shin, Soo Hyun, Michael F. Wendland, Brandon Zhang, An Tran, Albert Tang, and Moriel H. Vandsburger. "Noninvasive imaging of renal urea handling by CEST‐MRI." Magnetic Resonance in Medicine 83, no. 3 (2019): 1034–44. http://dx.doi.org/10.1002/mrm.27968.

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26

Pavuluri, KowsalyaDevi, and Michael T. McMahon. "pH Imaging Using Chemical Exchange Saturation Transfer (CEST) MRI." Israel Journal of Chemistry 57, no. 9 (2017): 862–79. http://dx.doi.org/10.1002/ijch.201700075.

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27

Dixon, W. Thomas, Ileana Hancu, S. James Ratnakar, A. Dean Sherry, Robert E. Lenkinski, and David C. Alsop. "A multislice gradient echo pulse sequence for CEST imaging." Magnetic Resonance in Medicine 63, no. 1 (2009): 253–56. http://dx.doi.org/10.1002/mrm.22193.

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28

Farrar, Christian T., Jason S. Buhrman, Guanshu Liu, et al. "Establishing the Lysine-rich Protein CEST Reporter Gene as a CEST MR Imaging Detector for Oncolytic Virotherapy." Radiology 275, no. 3 (2015): 746–54. http://dx.doi.org/10.1148/radiol.14140251.

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29

Sawaya, Reika, Junpei Ueda, and Shigeyoshi Saito. "Quantitative Susceptibility Mapping and Amide Proton Transfer-Chemical Exchange Saturation Transfer for the Evaluation of Intracerebral Hemorrhage Model." International Journal of Molecular Sciences 24, no. 7 (2023): 6627. http://dx.doi.org/10.3390/ijms24076627.

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This study aimed to evaluate an intracerebral hemorrhage (ICH) model using quantitative susceptibility mapping (QSM) and chemical exchange saturation transfer (CEST) with preclinical 7T-magnetic resonance imaging (MRI) and determine the potential of amide proton transfer-CEST (APT-CEST) for use as a biomarker for the early detection of ICH. Six Wistar male rats underwent MRI, and another six underwent histopathological examinations on postoperative days 0, 3, and 7. The ICH model was created by injecting bacterial collagenase into the right hemisphere of the brain. QSM and APT-CEST MRI were pe

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30

Cai, Zimeng, Qiaoling Zhong, Yanqiu Feng, et al. "Non-invasive mapping of brown adipose tissue activity with magnetic resonance imaging." Nature Metabolism 6, no. 7 (2024): 1367–79. http://dx.doi.org/10.1038/s42255-024-01082-z.

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AbstractThermogenic brown adipose tissue (BAT) has a positive impact on whole-body metabolism. However, in vivo mapping of BAT activity typically relies on techniques involving ionizing radiation, such as [18F]fluorodeoxyglucose ([18F]FDG) positron emission tomography (PET) and computed tomography (CT). Here we report a noninvasive metabolic magnetic resonance imaging (MRI) approach based on creatine chemical exchange saturation transfer (Cr-CEST) contrast to assess in vivo BAT activity in rodents and humans. In male rats, a single dose of the β3-adrenoceptor agonist (CL 316,243) or norepineph

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31

Chen, Yu-Wen, Hong-Qing Liu, Qi-Xuan Wu, et al. "pH Mapping of Skeletal Muscle by Chemical Exchange Saturation Transfer (CEST) Imaging." Cells 9, no. 12 (2020): 2610. http://dx.doi.org/10.3390/cells9122610.

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Magnetic resonance imaging (MRI) is extensively used in clinical and basic biomedical research. However, MRI detection of pH changes still poses a technical challenge. Chemical exchange saturation transfer (CEST) imaging is a possible solution to this problem. Using saturation transfer, alterations in the exchange rates between the solute and water protons because of small pH changes can be detected with greater sensitivity. In this study, we examined a fatigued skeletal muscle model in electrically stimulated mice. The measured CEST signal ratio was between 1.96 ppm and 2.6 ppm in the z-spect

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32

Liu, Jing, Chengyan Chu, Jia Zhang, et al. "Label-Free Assessment of Mannitol Accumulation Following Osmotic Blood–Brain Barrier Opening Using Chemical Exchange Saturation Transfer Magnetic Resonance Imaging." Pharmaceutics 14, no. 11 (2022): 2529. http://dx.doi.org/10.3390/pharmaceutics14112529.

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Purpose: Mannitol is a hyperosmolar agent for reducing intracranial pressure and inducing osmotic blood–brain barrier opening (OBBBO). There is a great clinical need for a non-invasive method to optimize the safety of mannitol dosing. The aim of this study was to develop a label-free Chemical Exchange Saturation Transfer (CEST)-based MRI approach for detecting intracranial accumulation of mannitol following OBBBO. Methods: In vitro MRI was conducted to measure the CEST properties of D-mannitol of different concentrations and pH. In vivo MRI and MRS measurements were conducted on Sprague-Dawley

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33

Kunth, Martin, Christopher Witte, and Leif Schröder. "Mapping of Absolute Host Concentration and Exchange Kinetics of Xenon Hyper-CEST MRI Agents." Pharmaceuticals 14, no. 2 (2021): 79. http://dx.doi.org/10.3390/ph14020079.

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Xenon magnetic resonance imaging (MRI) provides excellent sensitivity through the combination of spin hyperpolarization and chemical exchange saturation transfer (CEST). To this end, molecular hosts such as cryptophane-A or cucurbit[n]urils provide unique opportunities to design switchable MRI reporters. The concentration determination of such xenon binding sites in samples of unknown dilution remains, however, challenging. Contrary to 1H CEST agents, an internal reference of a certain host (in this case, cryptophane-A) at micromolar concentration is already sufficient to resolve the entire ex

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34

Nasrallah, Fatima A., Guilhem Pagès, Philip W. Kuchel, Xavier Golay, and Kai-Hsiang Chuang. "Imaging Brain Deoxyglucose Uptake and Metabolism by Glucocest MRI." Journal of Cerebral Blood Flow & Metabolism 33, no. 8 (2013): 1270–78. http://dx.doi.org/10.1038/jcbfm.2013.79.

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2-Deoxy-D-glucose (2DG) is a known surrogate molecule that is useful for inferring glucose uptake and metabolism. Although 13C-labeled 2DG can be detected by nuclear magnetic resonance (NMR), its low sensitivity for detection prohibits imaging to be performed. Using chemical exchange saturation transfer (CEST) as a signal-amplification mechanism, 2DG and the phosphorylated 2DG-6-phosphate (2DG6P) can be indirectly detected in 1H magnetic resonance imaging (MRI). We showed that the CEST signal changed with 2DG concentration, and was reduced by suppressing cerebral metabolism with increased gene

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35

Abecassis Schmitz, B., E. Ercan, J. de Bresser, et al. "P15.12.A Amine CEST contrast in gliomas to measure metabolic treatment effect at 7T." Neuro-Oncology 24, Supplement_2 (2022): ii86. http://dx.doi.org/10.1093/neuonc/noac174.302.

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Abstract Background Chemical exchange saturation transfer (CEST) is an imaging technique that generates contrast based on proton exchange between water and a solute pool of interest. CEST is sensitive to molecules containing amine groups such as glutamate and creatine. Since creatine is a crucial metabolite in cellular metabolism and deregulation in cellular bioenergetics is a hallmark of cancer, CEST could be relevant for glioma imaging, specifically when evaluating treatment response. No clear consensus has been established on its use, therefore we wanted to preliminarily investigate the pre

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36

Villano, Daisy, Feriel Romdhane, Pietro Irrera, et al. "A fast multislice sequence for 3D MRI‐CEST pH imaging." Magnetic Resonance in Medicine 85, no. 3 (2020): 1335–49. http://dx.doi.org/10.1002/mrm.28516.

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37

Carniato, Fabio, Giuseppe Ferrauto, Mónica Muñoz-Úbeda, and Lorenzo Tei. "Water Diffusion Modulates the CEST Effect on Tb(III)-Mesoporous Silica Probes." Magnetochemistry 6, no. 3 (2020): 38. http://dx.doi.org/10.3390/magnetochemistry6030038.

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The anchoring of lanthanide(III) chelates on the surface of mesoporous silica nanoparticles (MSNs) allowed their investigation as magnetic resonance imaging (MRI) and chemical exchange saturation transfer (CEST) contrast agents. Since their efficiency is strongly related to the interaction occurring between Ln-chelates and “bulk” water, an estimation of the water diffusion inside MSNs channels is very relevant. Herein, a method based on the exploitation of the CEST properties of TbDO3A-MSNs was applied to evaluate the effect of water diffusion inside MSN channels. Two MSNs, namely MCM-41 and S

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Schmitt, Benjamin, Martin Brix, and Stephan Domayer. "CEST Imaging." Current Radiology Reports 2, no. 3 (2014). http://dx.doi.org/10.1007/s40134-013-0038-4.

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39

Chung, Julius Juhyun, and Tao Jin. "Correction of the post-irradiation T1 relaxation effect for chemical exchange-sensitive MRI: A phantom study." Frontiers in Physics 10 (October 21, 2022). http://dx.doi.org/10.3389/fphy.2022.1033767.

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Purpose: In many pulse sequences of chemical exchange-sensitive MRI including multi-slice chemical exchange saturation transfer (CEST) or chemical exchange sensitive spin-lock (CESL), there is a finite time delay between the irradiation preparation and the imaging acquisition, during which the T1-relaxation reduces the chemical exchange contrast and affects the accuracy for volumetric imaging. We propose a simple post-acquisition method to correct this contamination.Methods: A simple formula was derived to evaluate the cross-slice T1-relaxation contamination in multi-slice echo-planar imaging

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A, Rong, Haoyu Wang, Chaoqun Nie, et al. "Glycerol-weighted chemical exchange saturation transfer nanoprobes allow 19F/1H dual-modality magnetic resonance imaging-guided cancer radiotherapy." Nature Communications 14, no. 1 (2023). http://dx.doi.org/10.1038/s41467-023-42286-3.

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AbstractRecently, radiotherapy (RT) has entered a new realm of precision cancer therapy with the introduction of magnetic resonance (MR) imaging guided radiotherapy systems into the clinic. Nonetheless, identifying an optimized radiotherapy time window (ORTW) is still critical for the best therapeutic efficacy of RT. Here we describe pH and O2 dual-sensitive, perfluorooctylbromide (PFOB)-based and glycerol-weighted chemical exchange saturation transfer (CEST) nano-molecular imaging probes (Gly-PFOBs) with dual fluorine and hydrogen proton based CEST MR imaging properties (19F/1H-CEST). Oxygena

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Mahmud, Sultan Z., and Hye‐Young Heo. "When CEST meets diffusion: Multi‐echo diffusion‐encoded CEST (dCEST) MRI to measure intracellular and extracellular CEST signal distributions." Magnetic Resonance in Medicine, April 14, 2025. https://doi.org/10.1002/mrm.30530.

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AbstractPurposeTo develop a multi‐echo, diffusion‐encoded chemical exchange saturation transfer (dCEST) imaging technique for estimating the intracellular and extracellular/intravascular contributions to the conventional CEST signal.MethodsA dCEST pulse sequence was developed to quantify the signal fractions, transverse relaxation times (T2), and apparent diffusion coefficient (ADC) of the intracellular and extracellular/intravascular water compartments. dCEST images were acquired across a wide range of TE, b‐values, RF saturation strengths, and frequency offsets. The data were analyzed using

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Sporkin, Helen L., Toral R. Patel, Yaqub Betz, et al. "Chemical Exchange Saturation Transfer Magnetic Resonance Imaging Identifies Abnormal Calf Muscle–Specific Energetics in Peripheral Artery Disease." Circulation: Cardiovascular Imaging 15, no. 7 (2022). http://dx.doi.org/10.1161/circimaging.121.013869.

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Background: Peripheral artery disease (PAD) results in exercise-induced ischemia in leg muscles. 31 Phosphorus (P) magnetic resonance spectroscopy demonstrates prolonged phosphocreatine recovery time constant after exercise in PAD but has low signal to noise, low spatial resolution, and requires multinuclear hardware. Chemical exchange saturation transfer (CEST) is a quantitative magnetic resonance imaging method for imaging substrate (CEST asymmetry [CEST asym ]) concentration by muscle group. We hypothesized that kinetics measured by CEST could distinguish between patients with PAD and contr

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Viswanathan, Malvika, Yashwant Kurmi, and Zhongliang Zu. "A rapid method for phosphocreatine‐weighted imaging in muscle using double saturation power‐chemical exchange saturation transfer." NMR in Biomedicine, December 19, 2023. http://dx.doi.org/10.1002/nbm.5089.

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Monitoring the variation in phosphocreatine (PCr) levels following exercise provides valuable insights into muscle function. Chemical exchange saturation transfer (CEST) has emerged as a sensitive method with which to measure PCr levels in muscle, surpassing conventional MR spectroscopy. However, existing approaches for quantifying PCr CEST signals rely on time‐consuming fitting methods that require the acquisition of the entire or a section of the CEST Z‐spectrum. Additionally, traditional fitting methods often necessitate clear CEST peaks, which may be challenging to obtain at low magnetic f

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44

Xu, Jianping, Tao Zu, Yi‐Cheng Hsu, Xiaoli Wang, Kannie W. Y. Chan, and Yi Zhang. "Accelerating CEST imaging using a model‐based deep neural network with synthetic training data." Magnetic Resonance in Medicine, October 22, 2023. http://dx.doi.org/10.1002/mrm.29889.

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AbstractPurposeTo develop a model‐based deep neural network for high‐quality image reconstruction of undersampled multi‐coil CEST data.Theory and MethodsInspired by the variational network (VN), the CEST image reconstruction equation is unrolled into a deep neural network (CEST‐VN) with a k‐space data‐sharing block that takes advantage of the inherent redundancy in adjacent CEST frames and 3D spatial–frequential convolution kernels that exploit correlations in the x‐ω domain. Additionally, a new pipeline based on multiple‐pool Bloch–McConnell simulations is devised to synthesize multi‐coil CES

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Cheema, Karandeep, Pei Han, Hsu‐Lei Lee, Yibin Xie, Anthony G. Christodoulou, and Debiao Li. "Accelerated CEST imaging through deep learning quantification from reduced frequency offsets." Magnetic Resonance in Medicine, September 13, 2024. http://dx.doi.org/10.1002/mrm.30269.

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AbstractPurposeTo shorten CEST acquisition time by leveraging Z‐spectrum undersampling combined with deep learning for CEST map construction from undersampled Z‐spectra.MethodsFisher information gain analysis identified optimal frequency offsets (termed “Fisher offsets”) for the multi‐pool fitting model, maximizing information gain for the amplitude and the FWHM parameters. These offsets guided initial subsampling levels. A U‐NET, trained on undersampled brain CEST images from 18 volunteers, produced CEST maps at 3 T with varied undersampling levels. Feasibility was first tested using retrospe

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Sedykh, Maria, Patrick Liebig, Kai Herz, et al. "snapshot CEST++ : the next snapshot CEST for fast whole‐brain APTw imaging at 3T." NMR in Biomedicine, April 19, 2023. http://dx.doi.org/10.1002/nbm.4955.

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Jin, Tao, and Julius Juhyun Chung. "Adjustment of rotation and saturation effects (AROSE) for CEST imaging." Magnetic Resonance in Medicine, November 27, 2023. http://dx.doi.org/10.1002/mrm.29938.

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AbstractPurposeEndogenous CEST signal usually has low specificity due to contaminations from the magnetization transfer contrast (MTC) and other labile protons with overlapping or close Larmor frequencies. We propose to improve CEST signal specificity with adjustment of rotation and saturation effects (AROSE).MethodsThe AROSE approach measures the difference between CEST signals acquired with the same average irradiation power but largely different duty cycles, for example, a continuous wave or a high duty cycle pulse train versus a low duty cycle pulse train with a flip angle φ. Simulation, p

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Larkin, James R., Lee Sze Foo, Brad A. Sutherland, Alexandre Khrapitchev, and Yee Kai Tee. "Magnetic Resonance pH Imaging in Stroke – Combining the Old With the New." Frontiers in Physiology 12 (February 3, 2022). http://dx.doi.org/10.3389/fphys.2021.793741.

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The study of stroke has historically made use of traditional spectroscopy techniques to provide the ground truth for parameters like pH. However, techniques like 31P spectroscopy have limitations, in particular poor temporal and spatial resolution, coupled with a need for a high field strength and specialized coils. More modern magnetic resonance spectroscopy (MRS)-based imaging techniques like chemical exchange saturation transfer (CEST) have been developed to counter some of these limitations but lack the definitive gold standard for pH that 31P spectroscopy provides. In this perspective, bo

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Chen, Bowei, Umara Khalid, Enhui Chai, and Li Chen. "Intuitionistic Fuzzy Position Embedding Transformer for Motion Artefact Correction in Chemical Exchange Saturation Transfer MRI Series." International Journal of Imaging Systems and Technology 35, no. 1 (2025). https://doi.org/10.1002/ima.70024.

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ABSTRACTChemical Exchange Saturation Transfer (CEST) Magnetic Resonance Imaging (MRI) is a cutting‐edge molecular imaging technique that enables non‐invasive in vivo visualization of biomolecules, such as proteins and glycans, with exchangeable protons. However, CEST MRI is prone to motion artefacts, which can significantly reduce its accuracy and reliability. To address this issue, this study proposes an image registration method specifically designed to correct motion artefacts in CEST MRI data, with the objective of improving the precision of CEST analysis. Traditional registration techniqu

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Zhou, Iris Y., Yang Ji, Yu Zhao, Malvika Viswanathan, Phillip Zhe Sun, and Zhongliang Zu. "Specific and rapid guanidinium CEST imaging using double saturation power and QUASS analysis in a rodent model of global ischemia." Magnetic Resonance in Medicine, December 14, 2023. http://dx.doi.org/10.1002/mrm.29960.

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AbstractPurposeGuanidinium CEST is sensitive to metabolic changes and pH variation in ischemia, and it can offer advantages over conventional pH‐sensitive amide proton transfer (APT) imaging by providing hyperintense contrast in stroke lesions. However, quantifying guanidinium CEST is challenging due to multiple overlapping components and a close frequency offset from water. This study aims to evaluate the applicability of a new rapid and model‐free CEST quantification method using double saturation power, termed DSP‐CEST, for isolating the guanidinium CEST effect from confounding factors in i

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