Academic literature on the topic 'Cfi1'
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Journal articles on the topic "Cfi1"
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Singh, Surendra, Avdhesh Sharma, Akhil Ranjan Garg, Om Prakash Mahela, Baseem Khan, Ilyes Boulkaibet, Bilel Neji, Ahmed Ali, and Julien Brito Ballester. "Power Quality Detection and Categorization Algorithm Actuated by Multiple Signal Processing Techniques and Rule-Based Decision Tree." Sustainability 15, no. 5 (February 28, 2023): 4317. http://dx.doi.org/10.3390/su15054317.
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This paper introduces a power quality (PQ) detection and categorization algorithm actuated by multiple signal processing techniques and rule-based decision tree (RBDT). This is aimed to recognize PQ events of simple nature and higher order multiplicity with less computational time using hybridization of the signal processing techniques. A voltage waveform with a PQ event (PQE) is processed using the Stockwell transform (ST) to compute the Stockwell PQ detection index (SPDI). The voltage waveform is also processed using the Hilbert transform (HT) to compute the Hilbert PQ detection index (HPDI). A voltage waveform is also decomposed using the Discrete Wavelet transform (DWT) to compute the classification feature index (CFI) [CFI1 to CFI4]. A combined PQ detection index (CPDI) is computed by multiplication of the SPDI, the HPDI and CFI1 to CFI4. Incidence of a PQE on a voltage signal is located with the help of a location PQ disturbance index (LPDI) which is computed by differentiating the CPDI with respect to time. CFI5, CFI6 and CFI7 are computed from the SPDI, the HPDI and the CPDI, respectively. Categorization of PQ events is performed using CFI1 to CFI7 by the rule-based decision tree (RBDT) with the help of simple decision rules. We conclude that the proposed algorithm is effective to identify the PQE with an accuracy of 98.58% in a noise-free environment and 97.62% in the presence of 20 dB SNR (signal-to-noise ratio) noise. Ten simple nature PQEs and eight combined PQ events (CPQEs) with multiplicity of two, three and four are effectively detected and categorized using the algorithm. The algorithm is also tested to detect a sag PQ event due to a line-to-ground (LG) fault incident on a practical distribution utility network. The performance of the investigated method is compared with a DWT-based technique in terms of accuracy of classification with and without noise, maximum computational time of PQ detection and multiplicity of PQE which can be effectively detected. A simulation is performed using the MATLAB software. MATLAB codes are used for modelling the PQE disturbances and the proposed algorithm using mathematical formulations.
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Visintin, Rosella, Frank Stegmeier, and Angelika Amon. "The Role of the Polo Kinase Cdc5 in Controlling Cdc14 Localization." Molecular Biology of the Cell 14, no. 11 (November 2003): 4486–98. http://dx.doi.org/10.1091/mbc.e03-02-0095.
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In budding yeast, the protein phosphatase Cdc14 controls exit from mitosis. Its activity is regulated by a competitive inhibitor Cfi1/Net1, which binds to and sequesters Cdc14 in the nucleolus. During anaphase, Cdc14 is released from its inhibitor by the action of two regulatory networks. The Cdc Fourteen Early Anaphase Release (FEAR) network initiates Cdc14 release from Cfi1/Net1 during early anaphase, and the Mitotic Exit Network (MEN) promotes Cdc14 release during late anaphase. Here, we investigate the relationship among FEAR network components and propose an order in which they function to promote Cdc14 release from the nucleolus. Furthermore, we examine the role of the protein kinase Cdc5, which is a component of both the FEAR network and the MEN, in Cdc14 release from the nucleolus. We find that overexpression of CDC5 led to Cdc14 release from the nucleolus in S phase-arrested cells, which correlated with the appearance of phosphorylated forms of Cdc14 and Cfi1/Net1. Cdc5 promotes Cdc14 phosphorylation and, by stimulating the MEN, Cfi1/Net1 phosphorylation. Furthermore, we suggest that Cdc14 release from the nucleolus only occurs when Cdc14 and Cfi1/Net1 are both phosphorylated.
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Jin, Quan-Wen, Samriddha Ray, Sung Hugh Choi, and Dannel McCollum. "The Nucleolar Net1/Cfi1-related Protein Dnt1 Antagonizes the Septation Initiation Network in Fission Yeast." Molecular Biology of the Cell 18, no. 8 (August 2007): 2924–34. http://dx.doi.org/10.1091/mbc.e06-09-0853.
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The septation initiation network (SIN) and mitotic exit network (MEN) signaling pathways regulate cytokinesis and mitotic exit in the yeasts Schizosaccharomyces pombe, and Saccharomyces cerevisiae, respectively. One function of these pathways is to keep the Cdc14-family phosphatase, called Clp1 in S. pombe, from being sequestered and inhibited in the nucleolus. In S. pombe, the SIN and Clp1 act as part of a cytokinesis checkpoint that allows cells to cope with cytokinesis defects. The SIN promotes checkpoint function by 1) keeping Clp1 out of the nucleolus, 2) maintaining the cytokinetic apparatus, and 3) halting the cell cycle until cytokinesis is completed. In a screen for suppressors of the SIN mutant cytokinesis checkpoint defect, we identified a novel nucleolar protein called Dnt1 and other nucleolar proteins, including Rrn5 and Nuc1, which are known to be required for rDNA transcription. Dnt1 shows sequence homology to Net1/Cfi1, which encodes the nucleolar inhibitor of Cdc14 in budding yeast. Like Net1/Cfi1, Dnt1 is required for rDNA silencing and minichromosome maintenance, and both Dnt1 and Net1/Cfi1 negatively regulate the homologous SIN and MEN pathways. Unlike Net1/Cfi1, which regulates the MEN through the Cdc14 phosphatase, Dnt1 can inhibit SIN signaling independently of Clp1, suggesting a novel connection between the nucleolus and the SIN pathway.
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Visintin, Rosella, and Angelika Amon. "Regulation of the Mitotic Exit Protein Kinases Cdc15 and Dbf2." Molecular Biology of the Cell 12, no. 10 (October 2001): 2961–74. http://dx.doi.org/10.1091/mbc.12.10.2961.
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In budding yeast, the release of the protein phosphatase Cdc14 from its inhibitor Cfi1/Net1 in the nucleolus during anaphase triggers the inactivation of Clb CDKs that leads to exit from mitosis. The mitotic exit pathway controls the association between Cdc14 and Cfi1/Net1. It is comprised of the RAS-like GTP binding protein Tem1, the exchange factor Lte1, the GTPase activating protein complex Bub2-Bfa1/Byr4, and several protein kinases including Cdc15 and Dbf2. Here we investigate the regulation of the protein kinases Dbf2 and Cdc15. We find that Cdc15 is recruited to both spindle pole bodies (SPBs) during anaphase. This recruitment depends on TEM1 but notDBF2 or CDC14 and is inhibited byBUB2. Dbf2 also localizes to SPBs during anaphase, which coincides with activation of Dbf2 kinase activity. Both events depend on the mitotic exit pathway components TEM1 andCDC15. In cells lacking BUB2, Dbf2 localized to SPBs in cell cycle stages other than anaphase and telophase and Dbf2 kinase was prematurely active during metaphase. Our results suggest an order of function of mitotic exit pathway components with respect to SPB localization of Cdc15 and Dbf2 and activation of Dbf2 kinase. BUB2 negatively regulates all 3 events. Loading of Cdc15 on SPBs depends on TEM1, whereas loading of Dbf2 on SPBs and activation of Dbf2 kinase depend onTEM1 and CDC15.
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Visintin, Rosella, Ellen S. Hwang, and Angelika Amon. "Cfi1 prevents premature exit from mitosis by anchoring Cdc14 phosphatase in the nucleolus." Nature 398, no. 6730 (April 1999): 818–23. http://dx.doi.org/10.1038/19775.
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Tomson, Brett N., Damien D'Amours, Brittany S. Adamson, Luis Aragon, and Angelika Amon. "Ribosomal DNA Transcription-Dependent Processes Interfere with Chromosome Segregation." Molecular and Cellular Biology 26, no. 16 (August 15, 2006): 6239–47. http://dx.doi.org/10.1128/mcb.00693-06.
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ABSTRACT The ribosomal DNA (rDNA) is a specialized genomic region not only owing to its function as the nucleolar organizing region (NOR) but also because it is repetitive in nature and, at least in budding yeast, silenced for polymerase II (Pol II)-mediated transcription. Furthermore, cohesin-independent linkages hold the sister chromatids together at the rDNA loci, and their resolution requires the activity of the conserved protein phosphatase Cdc14. Here we show that rRNA transcription-dependent processes establish linkages at the rDNA, which affect segregation of this locus. Inactivation of Cfi1/Net1, a protein required for efficient rRNA transcription, or elimination of Pol I activity, which drives rRNA transcription, diminishes the need for CDC14 in rDNA segregation. Our results identify Pol I transcription-dependent processes as a novel means of establishing linkages between chromosomes.
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Manzoni, Romilde, Francesca Montani, Clara Visintin, Fabrice Caudron, Andrea Ciliberto, and Rosella Visintin. "Oscillations in Cdc14 release and sequestration reveal a circuit underlying mitotic exit." Journal of Cell Biology 190, no. 2 (July 26, 2010): 209–22. http://dx.doi.org/10.1083/jcb.201002026.
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In budding yeast, the phosphatase Cdc14 orchestrates progress through anaphase and mitotic exit, thereby resetting the cell cycle for a new round of cell division. Two consecutive pathways, Cdc fourteen early anaphase release (FEAR) and mitotic exit network (MEN), contribute to the progressive activation of Cdc14 by regulating its release from the nucleolus, where it is kept inactive by Cfi1. In this study, we show that Cdc14 activation requires the polo-like kinase Cdc5 together with either Clb–cyclin-dependent kinase (Cdk) or the MEN kinase Dbf2. Once active, Cdc14 triggers a negative feedback loop that, in the presence of stable levels of mitotic cyclins, generates periodic cycles of Cdc14 release and sequestration. Similar phenotypes have been described for yeast bud formation and centrosome duplication. A common theme emerges where events that must happen only once per cycle, although intrinsically capable of oscillations, are limited to one occurrence by the cyclin–Cdk cell cycle engine.
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Waples, William G., Charly Chahwan, Marta Ciechonska, and Brigitte D. Lavoie. "Putting the Brake on FEAR: Tof2 Promotes the Biphasic Release of Cdc14 Phosphatase during Mitotic Exit." Molecular Biology of the Cell 20, no. 1 (January 2009): 245–55. http://dx.doi.org/10.1091/mbc.e08-08-0879.
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The completion of chromosome segregation during anaphase requires the hypercondensation of the ∼1-Mb rDNA array, a reaction dependent on condensin and Cdc14 phosphatase. Using systematic genetic screens, we identified 29 novel genetic interactions with budding yeast condensin. Of these, FOB1, CSM1, LRS4, and TOF2 were required for the mitotic condensation of the tandem rDNA array localized on chromosome XII. Interestingly, whereas Fob1 and the monopolin subunits Csm1 and Lrs4 function in rDNA condensation throughout M phase, Tof2 was only required during anaphase. We show that Tof2, which shares homology with the Cdc14 inhibitor Net1/Cfi1, interacts with Cdc14 phosphatase and its deletion suppresses defects in mitotic exit network (MEN) components. Consistent with these genetic data, the onset of Cdc14 release from the nucleolus was similar in TOF2 and tof2Δ cells; however, the magnitude of the release was dramatically increased in the absence of Tof2, even when the MEN pathway was compromised. These data support a model whereby Tof2 coordinates the biphasic release of Cdc14 during anaphase by restraining a population of Cdc14 in the nucleolus after activation of the Cdc14 early anaphase release (FEAR) network, for subsequent release by the MEN.
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Liang, Fengshan, Fengzhi Jin, Hong Liu, and Yanchang Wang. "The Molecular Function of the Yeast Polo-like Kinase Cdc5 in Cdc14 Release during Early Anaphase." Molecular Biology of the Cell 20, no. 16 (August 15, 2009): 3671–79. http://dx.doi.org/10.1091/mbc.e08-10-1049.
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In the budding yeast Saccharomyces cerevisiae , Cdc14 is sequestered within the nucleolus before anaphase entry through its association with Net1/Cfi1, a nucleolar protein. Protein phosphatase PP2ACdc55 dephosphorylates Net1 and keeps it as a hypophosphorylated form before anaphase. Activation of the Cdc fourteen early anaphase release (FEAR) pathway after anaphase entry induces a brief Cdc14 release from the nucleolus. Some of the components in the FEAR pathway, including Esp1, Slk19, and Spo12, inactivate PP2ACdc55, allowing the phosphorylation of Net1 by mitotic cyclin-dependent kinase (Cdk) (Clb2-Cdk1). However, the function of another FEAR component, the Polo-like kinase Cdc5, remains elusive. Here, we show evidence indicating that Cdc5 promotes Cdc14 release primarily by stimulating the degradation of Swe1, the inhibitory kinase for mitotic Cdk. First, we found that deletion of SWE1 partially suppresses the FEAR defects in cdc5 mutants. In contrast, high levels of Swe1 impair FEAR activation. We also demonstrated that the accumulation of Swe1 in cdc5 mutants is responsible for the decreased Net1 phosphorylation. Therefore, we conclude that the down-regulation of Swe1 protein levels by Cdc5 promotes FEAR activation by relieving the inhibition on Clb2-Cdk1, the kinase for Net1 protein.
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Riaz, Muhammad Hasnain, Aamir Iqbal, Samiullah Khan, Muhammad Tahir, Mian Nazir Shah, Sameeullah Memoon, Peter Karkach, et al. "EFFECT OF PROTEASE SUPPLEMENTATION ON THE PERFORMANCE AND DIGESTIBILITY OF BROILERS." Tehnologìâ virobnictva ì pererobki produktìv tvarinnictva, no. 1(156) (May 25, 2020): 15–21. http://dx.doi.org/10.33245/2310-9270-2020-157-1-15-21.
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Premise of the study was to validate the growth promoting eff ect of protease on the performance and to explore its digestion enhancer eff ect in broiler chicks. For this purpose 4 commercial diets were divided into two types (low and high density) and were enriched with protease using a completely randomized design with 4 replicates per diet having 10 chicks each having totaled 200 poultry broiler chickens (day-old). Until 14 days, no eff ects were observed on chicks however at day 14; little variations were observed on weight gain, feed intake and FCR (feed conversion ratio) among the enzyme enriched diets. At day 28, prominent response of protease supplementation in low protein was procured. The chicks gained 10.06 and 8.0 % more weight on CFP1 than CFG1 and CFG2, respectively. Similar response in FCR was observed and was found to be 0.20 and 0.15 points better on CFP1 than on CFG1 and CFG2, respectively. However, CFP2 failed to show protease effi cacy declining the weight gain by 23.01 % while the FCR by 0.49 points as compared with CFP1. This suggested that the nature of feed ingredients in the diets is important for obtaining maximum benefi t of protease supplementation. The overall performance indicated signifi cant response to enzyme supplemented diets. Among the low protein diets CP digestibility remained unchanged but they were diff erent in sparing AME (apparent metabolizable energy) for chicks. The CFP2 spared 98.21 kcal/Kg more AME than CFP1. However, this increased AME values did not help to boost the performance and was attributed to the widening ratio between CP and AME. These results demonstrated that the overall growth response of chicks was improved on low protein diet enriched with protease. It showed higher CP digestibility and AME values than good quality diets. However, the inconsistent results observed within the two types of diets revealed that the nature of diets might have infl uenced the effi cacy of protease. Key words: Broilers, digestibility, protease, FCR, Feed intake.
Dissertations / Theses on the topic "Cfi1"
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Mimun, G. M. F. "CDC5-MEDIATED PHOSPHORYLATION OF CLB2, CDC14 AND/OR CFI1 IS REQUIRED FOR THE NUCLEOLAR RELEASE OF CDC14." Doctoral thesis, Università degli Studi di Milano, 2011. http://hdl.handle.net/2434/156038.
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In budding yeast, the protein phosphatase Cdc14 is a critical regulator of exit from mitosis. Cdc14 activity is regulated by changes in its subcellular localization. The phosphatase is sequestered in the nucleolus from G1 up to metaphase by binding to a competitive inhibitor called Cfi1. During anaphase, Cdc14 is released from its inhibitor by the sequential activation of two signaling networks, the FEAR network and the MEN. Several observations suggest that phosphorylation of Cdc14 and/or Cfi1 is responsible for the dissociation of Cdc14 from Cfi1. Three kinases play a relevant role in regulating Cdc14 release: the polo-like kinase Cdc5, the Clb2-Cdk complex and the MEN kinase Dbf2. The aim of my project was to assess the relevance of the phosphorylation of Cdc14 and Cfi1 for Cdc14 release and to investigate the contribution of the mentioned kinases to this process. By modulating the kinases of interest, we found that a correlation exists between the release of Cdc14 from the nucleolus and the phosphorylation of both Cdc14 and Cfi1. Our results suggest a role for Cdc5 in promoting the phosphorylation of Cdc14 and for Clb-Cdk and MEN in promoting the phosphorylation of Cfi1. Moreover we propose that Cfi1 phosphorylation by Clb-Cdk or MEN serves as a priming step to build up the Cdc5-mediated phosphorylation events. Our data also suggest that Clb2-Cdk is not sufficient to promote Cfi1 phosphorylation and that phosphorylation of Clb2 by Cdc5 could enable the protein to perform its function in the FEAR network, likely to promote Cfi1phosphorylation.
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Holmér, Fredrik. "CFIL-Sundbyberg." Thesis, KTH, Arkitektur, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-187883.
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Jag läste uppgiften som ett nutida ABF-hus dit man kan komma för att lära sig allt från odling, metallslöjd och yoga till omvårdnad, drama och konst. Jag tycker också att platsen har ett intressant strategiskt läge nära Sundbybergs station med mycket goda kommunikationer och precis i den punkt där bostäder möter, shoppinggator och industriområdet Solna business park. Här finns alltså alla möjligheter för nya spännande möten och utbyten. För att ta tillvara denna möjlighet så har jag skapat ett torgrum med kopplingar till de olika vägarna som kommer mest naturligt från de olika områdena. Detta för att jag framför allt tycker att det saknas platser av lugn och avslappning i området. Ett parkliknande torg skulle då kunna fylla denna lucka då platsen är väldigt tyst och lugn, har delvis mycket goda solförhållanden och programmet för CFIL innehåller inomhus- och utomhusodling. En win-win alltså. Programmet innehåller också ett café men man skulle lika gärna kunna ta med sig egen lunch att äta på platsen.This project is about a centre for informal learning, CFIL in Sundbybergs kommun. I read the task as a contemporary ABF-house where people can come to learn everything from cultivation, metalwork and yoga to nursing, drama and art. I also think that the place has an interesting strategic position close to Sundbyberg station with very good transport links and just at the point where the housing meets, shopping streets and the industrial area Solna Business Park. So, those are all possibilities for exciting new encounters and exchanges. To take advantage of this opportunity, I have created a torgrum with links to the different paths that come most naturally from the different areas. This is because I find that there is a lack of places of peace and relaxation in the area. A park-like square would then be able to fill this gap since the property is very quiet and calm has partly very good sun conditions and the program for CFIL includes indoor and outdoor cultivation. A win-win, that is. The program also includes a cafe but you might as well bring your own lunch to eat on the spot.
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Wang, Yonghua. "CFC1₃ transport in the atmosphere." Diss., Georgia Institute of Technology, 1995. http://hdl.handle.net/1853/25974.
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Brown, David. "Understanding the role of CFP1 at CpG islands." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:baf2e91a-4417-407a-8938-bbef1f6c411f.
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Vertebrate genomes are punctuated by CpG islands regions, which have an elevated frequency of CpG dinucleotides. CpG islands are associated with over 70% of mammalian promoters suggesting they may contribute to the regulation of transcription. However, despite being discovered over 30 years ago, the function of CpG islands is still not understood. Unlike the majority of the genome, CpG islands are resistant to DNA methylation. This provides a binding site for CFP1 which binds specifically to non-methylated DNA via its zinc-finger CXXC (zf-CXXC) domain. CFP1 is a subunit of the SET1 methyltransferase complex, and is thought to direct the activating histone modification H3K4me3 to CpG islands. Interestingly, CFP1 also contains a PHD domain which is proposed to bind the H3K4me3 mark, potentially producing a feedback loop between H3K4me3 and the SET1 complex. Although the structural basis for discrimination of non-methylated CpGs is known, it is not clear how zf-CXXC proteins distinguish CpG islands amongst the irregular nucleosomal landscape which exists within the nucleus. This thesis is focused on the role of CFP1 in the relationship between CpG islands, SET1 and H3K4me3. To address these questions, it was important to mechanistically dissect the contribution of the PHD and zf-CXXC domains. The proposal that the PHD domain of CFP1 binds selectively to H3K4me3 was confirmed by in vitro experiments, however this study demonstrates that the PHD domain is insufficient for stable interactions with chromatin. Using complementary genome-wide and live cell imaging approaches, the zf-CXXC domain shown to be required for PHD-dependent interactions. Genome-wide snapshots of binding interactions, together with spatial and temporal details, expose a surprising contribution of the SET1 complex to the nuclear mobility of CFP1, providing a new perspective on the role of CFP1 in H3K4 methylation.
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Xiao, Song. "Research on insulation performance of SF6 substitute CF31/CO2 under power frequency voltage and the influence of micro-moisture on CF31." Thesis, Toulouse 3, 2016. http://www.theses.fr/2016TOU30184/document.
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Les appareillages utilisant des gaz de coupure se sont fortement développés dans les réseaux haute et ultra-haute tension de par leur grande stabilité, leur faible maintenance, faible surface au sol, et leur configuration flexible. De nos jours, le SF6 est utilisé comme gaz principal dans la majeure partie des équipements de coupure haute tension, mais il reste un gaz à effet de serre dont les émissions sont néfastes pour l'environnement. Il devient donc indispensable de trouver des solutions alternatives au SF6 dans ces dispositifs électriques, comme son remplacement par des gaz moins polluants. Dans une optique de certification, des tests sont réalisés systématiquement pour évaluer les caractéristiques d'isolation du mélange sous une tension de fonctionnement, ici du CF3I/CO2. Les caractéristiques isolantes du gaz pur CF3I et des mélanges CF3I/CO2 sont testées sous différents types de défaut et l'influence des particules métalliques est évaluée au travers des propriétés thermodynamiques et des propriétés de transport d'un plasma CF3I contaminé par ces particules. Les performances globales du CF3I/CO2 (électriques et thermiques) sont donc évaluées sous des contraintes typiques et pour des matériaux métalliques différents. Enfin, l'impact de l'humidité (aléatoirement présente dans les dispositifs) sur la tenue diélectrique de l'appareil est étudié car sa présence peut avoir des conséquences dramatiquesA large amount of gas insulated equipment are applied widely as the key part of power system. Gas insulated equipment develop quickly and used widely in high and ultra-high voltage field owing to its high stability, less maintenance work, smaller floor space, and flexible configuration. Nowadays, SF6 is adopted as the main insulation medium of gas insulated equipment, which is considered a kind of dangerous greenhouse gas to environment. Global climate warming caused by greenhouse effect brings disastrous consequences to our living conditions. Electric devices account much for the emission of SF6, which makes it urgent to find a kind of environment-friendly substitute insulating gas. Besides, the decomposed products of SF6 under discharge may be corrosive to internal material and poisonous to power workers. In the early period of global research and development of environment-friendly insulated devices, mastering the formula and key technique of substitute gas is vital to electrical development. According to the above circumstance, systematic investigation of the insulating characteristics of CF3I/CO2 mixed gases under power-frequency voltage was carried out firstly, which could provide useful information for the best mixed ratio of CF3I/CO2 and the design of internal structure in matching devices. Then insulating characteristic of CF3I/CO2 and CF3I were tested under a kind of normal insulating defect of free metal particles defect, and the influence of metal particles on the thermodynamic characteristics and transmission properties of CF3I discharge plasma were calculated theoretically. The overall performance of CF3I/CO2 under typical defects were tested for the choice of internal metal materials of electrical devices. Finally, the influence of moisture, the main hazardous material on gas insulated equipment, on the insulating performance of CF3I were conducted experimentally and theoretically, which proved the harmful effect of moisture on the new insulating medium and provided theoretical foundation for the standard constitution of moisture content
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Beurton, Flore. "Étude de l’interaction physique et fonctionnelle entre le complexe histone méthyltransférase SET-2/SET1 et le complexe histone déacétylase SIN-3S dans l’embryon de C. elegans." Thesis, Lyon, 2018. http://www.theses.fr/2018LYSEN017.
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Les complexes histones méthyltransférases SET1, hautement conservés de la levure aux mammifères, sont ciblés aux régions promotrices par la protéine CFP1/CXXC, résultant en l’implémentation de la méthylation de la lysine 4 de l’histone H3 (H3K4me), modification post-traductionnelle influençant l’expression des gènes selon le contexte chromatinien. La présence de plusieurs complexes SET1 distincts dans différents systèmes modèles eucaryotes a compliqué l’étude de leurs fonctions dans un contexte développemental. Caenorhabditis elegans contient une seule protéine homologue de SET1, SET-2, et d’uniques homologues des autres sous-unités du complexe, RBBP5, ASH2, WDR5, DPY30 et CFP1. Cependant, la composition biochimique du complexe n’a pas été décrite. En couplant des expériences de co-immunoprécipitation avec des analyses de spectrométrie de masse, j’ai identifié le complexe SET-2/SET1 dans les embryons de C. elegans. D’autre part, j’ai montré que le complexe SET-2/SET1 co-immunoprécipite aussi un autre complexe conservé modifiant la chromatine et j’ai mis en évidence les interactions mises en jeu entre ces deux complexes. Mon analyse génétique a démontré que les mutants de perte de fonction des sous-unités des deux complexes partagent des phénotypes communs, en cohérence avec des fonctions développementales communes. Le laboratoire a également entrepris des expériences de transcriptomique et d’immunoprécipitation de la chromatine montrant un nouveau rôle de CFP-1 dans le recrutement de ce complexe au niveau de sites spécifiques de la chromatineThe highly conserved SET1 family complexes are targeted by CFP1/CXXC protein to promoter regions through multivalent interactions to implement methylation of histone H3 Ly4 (H3K4me), a modification that correlates with gene expression depending on the chromatin context. The presence of distinct SET1 complexes in multiple eukaryotic model systems has hampered studies aimed at identifying the complete array of functions of SET1/MLL regulatory networks in a developmental context. Caenorhabditis elegans contains one SET1 protein, SET-2, one MLL-like protein, SET-16, and single homologs of RBBP5, ASH2, WDR5, DPY30 and CFP1. The biochemical composition of the complex however, has not been described. Through the use of co-immunoprecipitation coupled to mass spectrometry-based proteomics, I identified the SET-2/SET1 complex in C. elegans embryos. Most importantly, I showed that the SET-2/SET1 complex also co-immunoprecipitates another conserved chromatin-modifying complex and I highlighted the interactions involved between these two complexes. My genetic analysis revealed that loss of function mutants of the two complex subunits share common phenotypes, consistent with common developmental functions. The laboratory has also undertaken transcriptomic and chromatin immunoprecipitation experiments showing that CFP-1 has a role in the binding of this complex at specific chromatin regions
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Adjei, David, and Stina Nilsson. "From project to practice : Creating conditions for digital healthcare implementation using the CFIR framework." Thesis, Umeå universitet, Institutionen för informatik, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-185741.
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Despite the phenomenal innovations and huge investments in healthcare, it is evident that some digital transformation innovations in the healthcare context fail to meet their desired outcomes. Whilst some researchers argue that this is partly due to ineffective implementation, others argue otherwise. Essentially, there is an outspoken need to evaluate implementation processes, and one way to do so is through the use of an implementation framework, where one such framework showing great potential is the Consolidated Framework for Implementation Research (CFIR). By using a qualitative case study through the lenses of the CFIR, the study carries out a summative evaluation and examination of a previously conducted implementation process in a region in the north of Sweden, with the purpose of developing a greater understanding of implementation processes in order to improve patient care, as well as experiences and outcomes of digital transformation implementations. The study successfully identifies factors of both success and challenge in relation to implementation processes, where some of the success factors include the involvement of caregivers in the process and competition of private healthcare providers, whilst some of the challenges include deficient involvement of end-users as well as lack of structure. The study unearths some lessons which can be used as a guide for future implementations within the healthcare context, but also other contexts as well.
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Hardy, Jessica. "Human cleavage factor I (CFIm) and its role in alternative polyadenylation of pre-mRNA." Thesis, University of Oxford, 2017. https://ora.ox.ac.uk/objects/uuid:a3ba5d10-b3fa-4ab7-9709-a0d642e21543.
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For many human protein-coding genes, alternative cleavage and polyadenylation (APA) of pre-mRNA generates distinct 3' untranslated regions (3'UTRs) with differing regulatory potential. Widespread 3'UTR shortening via APA occurs in proliferative cell states, including cancer, where it can lead to oncogene overexpression. There has therefore been significant interest in identifying factors which influence poly(A) site choice in different physiological states. The multi-subunit human cleavage factor I complex (CFIm), a core component of the mammalian pre-mRNA cleavage machinery, has been identified as a potential master regulator of APA, as its depletion leads to widespread 3'UTR shortening. However, mechanistic understanding of how CFIm influences poly(A) site selection, and how its activity is regulated, is lacking. In this work, gene editing was used to generate cell lines with substantial, permanent depletion of the 25 kDa or 68 kDa subunits of CFIm (CFIm25 and CFIm68), which exhibited the expected 3'UTR shortening for representative transcripts. Reversal of this 3'UTR shortening by CFIm25 or CFIm68 re-expression provided the basis for a complementation assay, which allowed various aspects of CFIm25 and CFIm68 function to be investigated in vivo. The capacity of CFIm25 to recognise UGUA RNA sequences was shown to make an important contribution to poly(A) site selection transcriptome-wide, and a novel function for the C-terminal arginine/serine-rich (RS domain) of CFIm68 in poly(A) site selection was identified. The potential contribution of CFIm post-translational modification (PTM) to APA regulation was also explored. Novel acetylation sites on CFIm25 and CFIm68 were identified, as well as extensive serine phosphorylation in the CFIm68 RS domain. Complementation analysis revealed that phosphomimetic mutations in this RS domain inhibited distal poly(A) site selection, suggesting a potential role for CFIm68 phosphorylation in APA regulation. Taken together, the findings presented here provide insights into several important determinants of CFIm function, and the complementation assay developed provides a useful tool for future investigations.
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Guzmán, Bernal Sofía Belén. "Efecto de lovastatina sobre células de carcinoma mamario canino (Canis lupus familiaris) CF41.Mg." Tesis, Universidad de Chile, 2018. http://repositorio.uchile.cl/handle/2250/171004.
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Memoria para optar al Título Profesional de Médico VeterinarioEl cáncer mamario es la neoplasia que se presenta con mayor frecuencia en la hembra canina reproductivamente entera. Diversos investigadores han demostrado que lovastatina exhibe un efecto antitumoral in vitro sobre diversas líneas celulares neoplásicas humanas, sin embargo, su potencial efecto aún no ha sido evaluado sobre células de carcinoma mamario canino. Lovastatina inhibe a la enzima hidroxi-metil-glutaril coenzima A (HMG-CoA) reductasa, bloqueando la biosíntesis de colesterol y de sus isoprenoides farnesil pirofosfato (FPP) y geranil-geranil pirofosfato (GGPP), importantes mediadores de algunas vías de transducción de señales asociadas a sobrevida celular. El objetivo de este estudio fue determinar los efectos de lovastatina sobre la proliferación, invasión y apoptosis de células de carcinoma mamario canino CF41.Mg. Se cultivaron células CF41.Mg y se trataron con lovastatina (0-20 μM) por diferentes tiempos. Luego, se evaluó viabilidad celular (método de reducción de MTS), invasión celular (método Transwell) y apoptosis (ensayo de Anexina V/Yoduro de Propidio). Lovastatina indujo una disminución significativa en la viabilidad celular (p ≤ 0.05), efecto que fue dependiente de su concentración y el tiempo. La invasión celular fue inhibida en respuesta a concentraciones no citotóxicas de lovastatina (p ≤ 0.05). Además, esta droga ejerció un efecto pro-apoptótico dependiente del tiempo (p ≤ 0.05). Estos resultados demuestran que lovastatina cumpliría un importante papel sobre la proliferación y capacidad invasiva de células de carcinoma mamario canino CF41.Mg, lo cual sustenta futuros estudios clínicos con esta droga
Mammary cancer is the tumor that occurs most frequently in the reproductively intact female dog. Several researchers have shown that lovastatin exhibits an in vitro antitumor effect on various human neoplastic cell lines, however, its potential effect has not yet been evaluated in canine mammary carcinoma cells. Lovastatin inhibits HMG-CoA reductase, blocking the biosynthesis of cholesterol and its isoprenoids FPP and GGPP, important mediators of some signal transduction pathways associated with cell survival. The aims of this study were to determine the effects of lovastatin on the proliferation, invasion and apoptosis of canine mammary carcinoma cells CF41.Mg. CF41.Mg cells were cultured and treated with lovastatin (0-20 μM) for different times. Then, cell viability (MTS reduction method), cell invasion (Transwell method) and apoptosis (Annexin V/Propidium Iodide assay) were evaluated. Lovastatin induced a significant decrease in cell viability (p ≤ 0.05), an effect that was dependent on its concentration and time. Cell invasion was inhibited in response to non-cytotoxic concentrations of lovastatin (p ≤ 0.05). In addition, lovastatin exerted a pro-apoptotic effect dependent on time (p ≤ 0.05). These results demonstrate that lovastatin would play an important role in the proliferation and invasive capacity of canine mammary carcinoma cells CF41.Mg, which supports future clinical studies with this drug
Proyecto Fondecyt 11110148
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Terraciano, Paula Barros. "Vitrificação versus congelamento lento não automatizado em tecido ovariano de camundongos CF1." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2016. http://hdl.handle.net/10183/151510.
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Introdução: a alta prevalência do câncer e o aumento significativo da sobrevivência em longo prazo geraram interesse quanto à preservação da fertilidade em mulheres jovens expostas a quimioterapia e radioterapia. Neste sentido estudos de congelamento de tecido ovariano para posterior transplante, abriram uma nova perspectiva de aplicação no tratamento e prevenção da infertilidade feminina. Objetivos: comparar dois protocolos de congelamento de tecido ovariano, um lento não automatizado e um por vitrificação, com o intuito de avaliar a viabilidade dos tecidos para posterior transplante autólogo. Método: Foram utilizadas 30 camundongos fêmea CF1 com aproximadamente 8 semanas e pesando 29,29g±2,9. •Os ovários extraídos foram vitrificados ou congelados, mantidos em nitrogênio líquido por 30 dias e descongelados. Após o descongelamento, o ovário esquerdo foi destinado às análises histológicas e caracterização por imuno histoquímica para o marcador mouse vasa homologue (MVH) e o ovário direito foi utilizado para os testes de viabilidade celular com exclusão por azul de trypan. Resultados: Nas análises de Hematoxilina e Eosina (HE) foram contados folículos primordiais, primários, pré-antrais e antrais. Não houve diferença significativa na proporção de folículos primordiais, primários e pré-antrais após descongelamento entre os grupos testados. A contagem de folículos antrais foi significativamente maior no grupo de vitrificação (p = 0,004). No ensaio de imunohistoquímica para o marcador MVH, folículos MVH + e MVH- foram contados e comparados com o número total de folículos. O grupo congelamento lento apresentou maior número de células não marcadas (p = 0,012). Conclusão: Embora ambos os protocolos tenham apresentado resultados semelhantes na análise histológica das contagens foliculares, o protocolo de vitrificação foi significativamente melhor para preservar a população de células tronco ovarianas.Introduction: The high prevalence of cancer and the significant increase in long-term survival have generated interest as the preservation of fertility in young women exposed to chemotherapy and radiotherapy. Experimental techniques have been tried in an attempt to reverse the ovarian failure induced by these treatments. In this regard studies of ovarian tissue freezing for subsequent transplantation disclose a new application perspective in the treatment and prevention of female infertility. Objective: two ovarian tissue freezing protocols were tested, a non-automated slow-freezing and by vitrification, in order to assess the viability of the tissues for subsequent autologous transplantation. Methods: as ovaries donors, were used 30 female CF1 mice approximately 8 weeks and weighing 29,29g±2,9. • The ovaries were vitrified or frozen, stored in liquid nitrogen for 30 days and thawed. After thawing, the left ovary was intended for histological and immunohistochemical characterization by histochemical marker for MVH and right ovary was used for the tests with cell viability by trypan blue exclusion. Results: In HE slides was counting primordial, primary, pre antral and antral follicles. No significant difference was found in the proportion of high-quality primordial, primary and pre antral follicles after thawing/warming in the slow-freezing and vitrification group, respectively. The antral follicle counting was significant higher in vitrification group (p=0,004). In immunohistochemistry assay for MVH Antibody , MVH+ and MVH- follicles were counted and compared with the total number of follicles and slow freeze group had a higher number of not marked cells (p=0,012). Conclusion: Although both protocols showed similar results in the histological analysis for follicular counts, the vitrification protocol was significantly better for preserve the ovarian stem cell population.
Books on the topic "Cfi1"
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1930-, Brigham Eugene F., ed. CFIN℗ø. Mason, OH: South Western Cengage Learning, 2012.
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Ontario. Ministry of Natural Resources., ed. CFIP, Community Fisheries Involvement Program. [Toronto]: Ontario Ministry of Natural Resources, 1989.
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Brown, Gregory N. The savvy flight instructor: Secrets of the successful CFI. Newcastle, Wash: Aviation Supplies & Academics, 1997.
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Kerr, S. J. Fish stocking activities under the Community Fisheries Involvement Programm (CFIP), 1982-2001. [Peterborough: Ontario Ministry of Natural Resources, Fish and Wildlife Branch], 2002.
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Kern, James R. The APEX CFI feasibility study: An independent assessment : final report. [Manila]: The Bureau, 1989.
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Weinreb, Michael P. Balloon-based infrared solar occultation measurements of stratospheric O, HO, HNO, and CFC1. Washington, D.C: National Environmental Satellite, Data, and Information Service, 1987.
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Weinreb, Michael P. Balloon-based infrared solar occultation measurements of stratospheric O, HO, HNO, and CFC1. Washington, D.C: National Environmental Satellite, Data, and Information Service, 1987.
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Portugal) Conference on Future Internet Communications (2013 Coimbra. 2013 Conference on Future Internet Communications (CFIC 2013): Coimbra, Portugal, 15-16 May 2013. Piscataway, NJ: IEEE, 2013.
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Melissa, Bud, United States. Federal Aviation Administration. Office of Aviation Research, and John A. Volpe National Transportation Systems Center (U.S.), eds. General aviation accidents, 1983-1994: Identification of factors related to controlled-flight-into-terrain (CFIT) accidents. Washington, D.C: Federal Aviation Administration, Office of Aviation Research, 1997.
Find full textBook chapters on the topic "Cfi1"
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Lopes, Fernanda M., Juliano Cé Coelho, Matheus H. Leal, Richard B. Parsons, and Fabio Klamt. "CFL1." In Encyclopedia of Signaling Molecules, 1034–39. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-67199-4_101634.
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Lopes, Fernanda M., Juliano Cé Coelho, Matheus H. Leal, Richard B. Parsons, and Fabio Klamt. "CFL1." In Encyclopedia of Signaling Molecules, 1–6. New York, NY: Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4614-6438-9_101634-1.
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Hirota, E., K. Kuchitsu, T. Steimle, J. Vogt, and N. Vogt. "15 CFIO Carbonic fluoride iodide." In Molecules Containing No Carbon Atoms and Molecules Containing One or Two Carbon Atoms, 246. Berlin, Heidelberg: Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/978-3-540-70614-4_216.
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Atri, Sanjeev, Vineet Tripathi, Gagandeep Kaur, and Sanjana Rani. "CFIP—Water Inhibitor Cable Jointing Kit." In Lecture Notes in Electrical Engineering, 173–78. Singapore: Springer Nature Singapore, 2022. http://dx.doi.org/10.1007/978-981-16-8727-3_17.
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Zhou, Xiang. "CFI Construction and Balanced Graphs." In Frontiers in Algorithmics, 97–107. Berlin, Heidelberg: Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-642-02270-8_12.
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Baerlocher, Ch, W. M. Meier, and D. H. Olson. "CFI." In Atlas of Zeolite Framework Types, 90–91. Elsevier, 2001. http://dx.doi.org/10.1016/b978-044450701-3/50327-x.
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"50 CFix Posterior Cervical System." In Spinal Instrumentation: Surgical Techniques, edited by Daniel H. Kim, Alexander R. Vaccaro, and Richard G. Fessler. Stuttgart: Georg Thieme Verlag, 2005. http://dx.doi.org/10.1055/b-0034-75874.
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"Combined Fouling Index (CFI)." In Encyclopedia of Membranes, 431. Berlin, Heidelberg: Springer Berlin Heidelberg, 2016. http://dx.doi.org/10.1007/978-3-662-44324-8_100074.
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Bhargava, Satish, and AK Srivastava. "Colour Flow Imaging (CFI)." In Textbook of Color Doppler Imaging, 31. Jaypee Brothers Medical Publishers (P) Ltd., 2007. http://dx.doi.org/10.5005/jp/books/10899_5.
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"Court of First Instance (CFI)." In Competition Law and Policy in the EU and UK, 84–85. Routledge-Cavendish, 2004. http://dx.doi.org/10.4324/9781843146711-15.
Full textConference papers on the topic "Cfi1"
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Gertsvolf, M., D. Grojo, S. Lei, L. Ramunno, D. M. Rayner, and P. B. Corkum. "Spontaneous Micro-Lens Formation and Reduction of Multiphoton Ionization inside Dielectrics." In Conference on Lasers and Electro-Optics. Washington, D.C.: OSA, 2009. http://dx.doi.org/10.1364/cleo.2009.cfi1.
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Nozaki, K., A. Shinya, S. Matsuo, T. Sato, Y. Kawaguchi, and M. Notomi. "Ultralow-power All-optical Memory using Photonic Crystal Nanocavities with Novel Buried Heterostructure." In CLEO: Science and Innovations. Washington, D.C.: OSA, 2011. http://dx.doi.org/10.1364/cleo_si.2011.cfi1.
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Zhang, Xiang. "Optical Metamaterials." In Conference on Lasers and Electro-Optics. Washington, D.C.: OSA, 2010. http://dx.doi.org/10.1364/cleo.2010.cfi1.
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Renhorn, Ingmar, Björn Broberg, and Kennet Vilhelmsson. "Coherent laser radar based on semiconductor laser technology." In The European Conference on Lasers and Electro-Optics. Washington, D.C.: Optica Publishing Group, 1994. http://dx.doi.org/10.1364/cleo_europe.1994.cfi1.
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Range, Doppler, and vibration measurements are used in a variety of applications, both military and civilian. The rapid laser development has brought about an increasing diversity in technology. Eye safety, low observability, and cost have been driving forces. A preferred wavelength is 1.54 μm, a wavelength that can be obtained by several types of lasers, one of which is the semiconductor laser. Semiconductor technology can lead to small, robust, and reasonably priced systems. The technology is compatible with fiber optics, which brings about the possibility to use a distributed sensor system. A special case already being exploited is in the area of time domain reflectometry. Due to the limited peak power capability of semiconductor lasers, direct detecting systems based on this technology have been background limited and only reached a limited capability. By using coherent detection and frequency modulation, close to quantum limited systems can be achieved. Similar capability might be obtained in a direct detecting system but only by making use of very advanced filter techniques. The linewidth of DFB and DBR lasers is now narrow enough for many applications. The advancement of semiconductor laser technology has motivated us to develop a compact and versatile coherent FMCW semiconductor laser radar.
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Braun, B., C. Hönninger, G. Zhang, U. Keller, F. Heine, T. Kellner, and G. Huber. "Efficient intracavity frequency doubling of a passively modelocked diode-pumped Nd:LSB laser." In The European Conference on Lasers and Electro-Optics. Washington, D.C.: Optica Publishing Group, 1996. http://dx.doi.org/10.1364/cleo_europe.1996.cfi1.
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We report for the first time a stable and simple method for intracavity frequency doubling of a solid-state laser passively modelocked by using a low-finesse antiresonant Fabry-Perot saturable absorber (A-FPSA [1]). With a Neodymium-Lanthanum-Scandium-Borate laser (Nd:LSB) as gain material and a beta-Barium-Borate (β-BBO) nonlinear crystal with type I phase matching, we achieved a conversion efficiency of 48% resulting in 190 mW output power of TEM00 green light at modest pump powers of 1.2 W. Intracavity frequency doubling is favourable for the low to intermediate power regime, where the typical peak intensities of the output beam are not sufficient to obtain high single pass nonlinear frequency conversion efficiencies. But random noise fluctuations in cw intracavity requency doubled lasers, caused by nonlinear coupling between the laser modes and referred to as the green problem [2], made these lasers inappropriate for many applications. This problem can be overcome with a ring laser approach, where 780 mW of green light at a pump power of 4 W could be shown [3], by the use of additional intracavity elements, which make the laser rather complex and critical to operate, or with the use of an external resonator, where up to 200 mW of green light were produced at a diode pump power of 1 W, but which requires electronic frequency locking elements [4], Another possibility to obtain stable output are modelocking techniques, which lock all longitudinal modes together in phase. We describe an all solid-state, completely passive approach for intracavity frequency doubling of a solid-state laser, which is stable, non critical to align, and does not require any electronic control elements.
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Axelsson, Rune. "Airborne Laser Surveying - Systems and Applications." In The European Conference on Lasers and Electro-Optics. Washington, D.C.: Optica Publishing Group, 1998. http://dx.doi.org/10.1364/cleo_europe.1998.cfi1.
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Airborne Laser Surveying - Systems and Applications. The capability to position accurately geographic data in the horizontal plane has increased enormously by the access to satellite positioning systems (GPS). GPS combined with technology of Laser Range Finding, LRF respectively Laserbathymetri, LBS form versatile tools for accurate survey. Systems for the two applications are presented.
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Ko, Myeonghoon, Tiejun Ma, and Shuping Xiong. "Effects of carbon fiber insole on lower-extremity muscle activation and wearing comfort during treadmill running." In 13th International Conference on Applied Human Factors and Ergonomics (AHFE 2022). AHFE International, 2022. http://dx.doi.org/10.54941/ahfe1002592.
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Background and Objective: Although the role of shoes on sports performance and injury has been extensively examined, only a few studies investigated the effects from insoles. Recent studies on carbon fiber insoles (CFI) on athletic performance reported that CFI could improve sports performance by reducing energy loss and increasing energy return. However, there are scarce reports on the effects of CFI on muscle fatigue and wearing comfort. While stiffer CFI insoles are superior in energy loss reduction and energy return, they could increase more muscle activation to absorb the shock or provide more propulsive force to push CFI, leading to increased muscle fatigue and discomfort. Therefore, this study aims to evaluate the effect of CFI on lower-extremity muscle activation and wearing comfort during treadmill running. Methods: Three types of insoles were compared, namely CFI, CFI with cushioning (CFIC), and a benchmark commercial insole (COM). Fifteen healthy young men participated in the experiment. Each participant wore the same sports shoe, three different insoles in a random order, and ran on a treadmill at a speed of 10 km/h for 5 minutes. Surface electromyography signals of four lower-extremity muscles (Rectus femoris, Tibialis anterior, Biceps femoris, and Gastrocnemius medialis) were recorded in real-time for measuring muscle activation. After completing a trial run with each experimental insole, the participants provided their subjective ratings on perceived insole stiffness, energy support, overall comfort, and fatigue. Analysis of variance (ANOVA) and post-hoc grouping analysis were conducted to statistically evaluate the effects from three different insoles. Paired t-test was performed to compare CFI and CFIC and explore any cushioning effect. Results: In terms of lower-extremity muscle activation, even though CFIC and COM showed no significant difference for all four lower-extremity muscles, CFI induced a marginally significant increase of 1.5% on Gastrocnemius medialis (p = 0.063) and a significant reduction of 0.7% on rectus femoris (p=0.011) than COM. For the subjective ratings, both CFI and CFIC were significantly stiffer than COM (p < 0.001), but there were no significant differences in overall comfort, energy support, and fatigue. Compared with CFI, CFIC significantly reduced Gastrocnemius medialis muscle usage by 2.1% (p = 0.012) and was marginally less stiff (p = 0.102).Conclusions: This preliminary study showed that the carbon fiber insole CFI induced higher calf muscle usage and was perceived to be stiffer during treadmill running, which could contribute to provide the propulsive force for better sports performance. Carbon fiber insole with cushioning (CFIC) can help to relieve muscular fatigue. Further research should be conducted to examine the carbon insole effects on sports performance and long-term muscle activation and perceived feelings.
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Schmalenberg, Mira, Lukas Hohmann, and Norbert Kockmann. "Miniaturized Tubular Cooling Crystallizer With Solid-Liquid Flow for Process Development." In ASME 2018 16th International Conference on Nanochannels, Microchannels, and Minichannels. American Society of Mechanical Engineers, 2018. http://dx.doi.org/10.1115/icnmm2018-7660.
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Production of fine chemicals and pharmaceuticals often includes solid-liquid suspension flow. For continuous cooling a tubular crystallizer was designed based on the coiled flow inverter (CFI) concept, providing a narrow residence time distribution (RTD) of the liquid phase. Counter-current cooling allows for a smooth adjustment of the axial temperature profile. Successful operation of up to 50 g min−1 in a prototype with 4 mm inner diameter was scaled down to a tube-in-tube CFI crystallizer (CFIC) with an inner diameter of 1.6 mm and varying length from 7.8 to 54.6 m. This leads to a significantly lower consumption of chemicals in process development with lower total mass flow rates of 15–20 g min−1. Due to modular design, mean residence time (3.8 to 6.9 min) and mean cooling rate (0.6 to 1.4 K·min−1) were varied at constant mass flow rate. Crystallization growth rate and yield are analyzed with the L-alanine/water test system and seed crystals of 125–180 μm.
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Takayuki Fujiwara and Hiroyasu Koshimizu. "On CFI and CFI-based filters." In SICE Annual Conference 2007. IEEE, 2007. http://dx.doi.org/10.1109/sice.2007.4421051.
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"CFIS 2019 Authors Index." In 2019 7th Iranian Joint Congress on Fuzzy and Intelligent Systems (CFIS). IEEE, 2019. http://dx.doi.org/10.1109/cfis.2019.8692160.
Full textReports on the topic "Cfi1"
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Smit, Amelia, Kate Dunlop, Nehal Singh, Diona Damian, Kylie Vuong, and Anne Cust. Primary prevention of skin cancer in primary care settings. The Sax Institute, August 2022. http://dx.doi.org/10.57022/qpsm1481.
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Overview Skin cancer prevention is a component of the new Cancer Plan 2022–27, which guides the work of the Cancer Institute NSW. To lessen the impact of skin cancer on the community, the Cancer Institute NSW works closely with the NSW Skin Cancer Prevention Advisory Committee, comprising governmental and non-governmental organisation representatives, to develop and implement the NSW Skin Cancer Prevention Strategy. Primary Health Networks and primary care providers are seen as important stakeholders in this work. To guide improvements in skin cancer prevention and inform the development of the next NSW Skin Cancer Prevention Strategy, an up-to-date review of the evidence on the effectiveness and feasibility of skin cancer prevention activities in primary care is required. A research team led by the Daffodil Centre, a joint venture between the University of Sydney and Cancer Council NSW, was contracted to undertake an Evidence Check review to address the questions below. Evidence Check questions This Evidence Check aimed to address the following questions: Question 1: What skin cancer primary prevention activities can be effectively administered in primary care settings? As part of this, identify the key components of such messages, strategies, programs or initiatives that have been effectively implemented and their feasibility in the NSW/Australian context. Question 2: What are the main barriers and enablers for primary care providers in delivering skin cancer primary prevention activities within their setting? Summary of methods The research team conducted a detailed analysis of the published and grey literature, based on a comprehensive search. We developed the search strategy in consultation with a medical librarian at the University of Sydney and the Cancer Institute NSW team, and implemented it across the databases Embase, MEDLINE, PsycInfo, Scopus, Cochrane Central and CINAHL. Results were exported and uploaded to Covidence for screening and further selection. The search strategy was designed according to the SPIDER tool for Qualitative and Mixed-Methods Evidence Synthesis, which is a systematic strategy for searching qualitative and mixed-methods research studies. The SPIDER tool facilitates rigour in research by defining key elements of non-quantitative research questions. We included peer-reviewed and grey literature that included skin cancer primary prevention strategies/ interventions/ techniques/ programs within primary care settings, e.g. involving general practitioners and primary care nurses. The literature was limited to publications since 2014, and for studies or programs conducted in Australia, the UK, New Zealand, Canada, Ireland, Western Europe and Scandinavia. We also included relevant systematic reviews and evidence syntheses based on a range of international evidence where also relevant to the Australian context. To address Question 1, about the effectiveness of skin cancer prevention activities in primary care settings, we summarised findings from the Evidence Check according to different skin cancer prevention activities. To address Question 2, about the barriers and enablers of skin cancer prevention activities in primary care settings, we summarised findings according to the Consolidated Framework for Implementation Research (CFIR). The CFIR is a framework for identifying important implementation considerations for novel interventions in healthcare settings and provides a practical guide for systematically assessing potential barriers and facilitators in preparation for implementing a new activity or program. We assessed study quality using the National Health and Medical Research Council (NHMRC) levels of evidence. Key findings We identified 25 peer-reviewed journal articles that met the eligibility criteria and we included these in the Evidence Check. Eight of the studies were conducted in Australia, six in the UK, and the others elsewhere (mainly other European countries). In addition, the grey literature search identified four relevant guidelines, 12 education/training resources, two Cancer Care pathways, two position statements, three reports and five other resources that we included in the Evidence Check. Question 1 (related to effectiveness) We categorised the studies into different types of skin cancer prevention activities: behavioural counselling (n=3); risk assessment and delivering risk-tailored information (n=10); new technologies for early detection and accompanying prevention advice (n=4); and education and training programs for general practitioners (GPs) and primary care nurses regarding skin cancer prevention (n=3). There was good evidence that behavioural counselling interventions can result in a small improvement in sun protection behaviours among adults with fair skin types (defined as ivory or pale skin, light hair and eye colour, freckles, or those who sunburn easily), which would include the majority of Australians. It was found that clinicians play an important role in counselling patients about sun-protective behaviours, and recommended tailoring messages to the age and demographics of target groups (e.g. high-risk groups) to have maximal influence on behaviours. Several web-based melanoma risk prediction tools are now available in Australia, mainly designed for health professionals to identify patients’ risk of a new or subsequent primary melanoma and guide discussions with patients about primary prevention and early detection. Intervention studies have demonstrated that use of these melanoma risk prediction tools is feasible and acceptable to participants in primary care settings, and there is some evidence, including from Australian studies, that using these risk prediction tools to tailor primary prevention and early detection messages can improve sun-related behaviours. Some studies examined novel technologies, such as apps, to support early detection through skin examinations, including a very limited focus on the provision of preventive advice. These novel technologies are still largely in the research domain rather than recommended for routine use but provide a potential future opportunity to incorporate more primary prevention tailored advice. There are a number of online short courses available for primary healthcare professionals specifically focusing on skin cancer prevention. Most education and training programs for GPs and primary care nurses in the field of skin cancer focus on treatment and early detection, though some programs have specifically incorporated primary prevention education and training. A notable example is the Dermoscopy for Victorian General Practice Program, in which 93% of participating GPs reported that they had increased preventive information provided to high-risk patients and during skin examinations. Question 2 (related to barriers and enablers) Key enablers of performing skin cancer prevention activities in primary care settings included: • Easy access and availability of guidelines and point-of-care tools and resources • A fit with existing workflows and systems, so there is minimal disruption to flow of care • Easy-to-understand patient information • Using the waiting room for collection of risk assessment information on an electronic device such as an iPad/tablet where possible • Pairing with early detection activities • Sharing of successful programs across jurisdictions. Key barriers to performing skin cancer prevention activities in primary care settings included: • Unclear requirements and lack of confidence (self-efficacy) about prevention counselling • Limited availability of GP services especially in regional and remote areas • Competing demands, low priority, lack of time • Lack of incentives.
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Totten, Annette, Dana M. Womack, Marian S. McDonagh, Cynthia Davis-O’Reilly, Jessica C. Griffin, Ian Blazina, Sara Grusing, and Nancy Elder. Improving Rural Health Through Telehealth-Guided Provider-to-Provider Communication. Agency for Healthcare Research and Quality, December 2022. http://dx.doi.org/10.23970/ahrqepccer254.
Full textAbstract:
Objectives. To assess the use, effectiveness, and implementation of telehealth-supported provider-to-provider communication and collaboration for the provision of healthcare services to rural populations and to inform a scientific workshop convened by the National Institutes of Health Office of Disease Prevention on October 12–14, 2021. Data sources. We conducted a comprehensive literature search of Ovid MEDLINE®, CINAHL®, Embase®, and Cochrane CENTRAL. We searched for articles published from January 1, 2015, to October 12, 2021, to identify data on use of rural provider-to-provider telehealth (Key Question 1) and the same databases for articles published January 1, 2010, to October 12, 2021, for studies of effectiveness and implementation (Key Questions 2 and 3) and to identify methodological weaknesses in the research (Key Question 4). Additional sources were identified through reference lists, stakeholder suggestions, and responses to a Federal Register notice. Review methods. Our methods followed the Agency for Healthcare Research and Quality Methods Guide (available at https://effectivehealthcare.ahrq.gov/topics/cer-methods-guide/overview) and the PRISMA reporting guidelines. We used predefined criteria and dual review of abstracts and full-text articles to identify research results on (1) regional or national use, (2) effectiveness, (3) barriers and facilitators to implementation, and (4) methodological weakness in studies of provider-to-provider telehealth for rural populations. We assessed the risk of bias of the effectiveness studies using criteria specific to the different study designs and evaluated strength of evidence (SOE) for studies of similar telehealth interventions with similar outcomes. We categorized barriers and facilitators to implementation using the Consolidated Framework for Implementation Research (CFIR) and summarized methodological weaknesses of studies. Results. We included 166 studies reported in 179 publications. Studies on the degree of uptake of provider-to-provider telehealth were limited to specific clinical uses (pharmacy, psychiatry, emergency care, and stroke management) in seven studies using national or regional surveys and claims data. They reported variability across States and regions, but increasing uptake over time. Ninety-seven studies (20 trials and 77 observational studies) evaluated the effectiveness of provider-to-provider telehealth in rural settings, finding that there may be similar rates of transfers and lengths of stay with telehealth for inpatient consultations; similar mortality rates for remote intensive care unit care; similar clinical outcomes and transfer rates for neonates; improvements in medication adherence and treatment response in outpatient care for depression; improvements in some clinical monitoring measures for diabetes with endocrinology or pharmacy outpatient consultations; similar mortality or time to treatment when used to support emergency assessment and management of stroke, heart attack, or chest pain at rural hospitals; and similar rates of appropriate versus inappropriate transfers of critical care and trauma patients with specialist telehealth consultations for rural emergency departments (SOE: low). Studies of telehealth for education and mentoring of rural healthcare providers may result in intended changes in provider behavior and increases in provider knowledge, confidence, and self-efficacy (SOE: low). Patient outcomes were not frequently reported for telehealth provider education, but two studies reported improvement (SOE: low). Evidence for telehealth interventions for other clinical uses and outcomes was insufficient. We identified 67 program evaluations and qualitative studies that identified barriers and facilitators to rural provider-to-provider telehealth. Success was linked to well-functioning technology; sufficient resources, including time, staff, leadership, and equipment; and adequate payment or reimbursement. Some considerations may be unique to implementation of provider-to-provider telehealth in rural areas. These include the need for consultants to better understand the rural context; regional initiatives that pool resources among rural organizations that may not be able to support telehealth individually; and programs that can support care for infrequent as well as frequent clinical situations in rural practices. An assessment of methodological weaknesses found that studies were limited by less rigorous study designs, small sample sizes, and lack of analyses that address risks for bias. A key weakness was that studies did not assess or attempt to adjust for the risk that temporal changes may impact the results in studies that compared outcomes before and after telehealth implementation. Conclusions. While the evidence base is limited, what is available suggests that telehealth supporting provider-to-provider communications and collaboration may be beneficial. Telehealth studies report better patient outcomes in some clinical scenarios (e.g., outpatient care for depression or diabetes, education/mentoring) where telehealth interventions increase access to expertise and high-quality care. In other applications (e.g., inpatient care, emergency care), telehealth results in patient outcomes that are similar to usual care, which may be interpreted as a benefit when the purpose of telehealth is to make equivalent services available locally to rural residents. Most barriers to implementation are common to practice change efforts. Methodological weaknesses stem from weaker study designs, such as before-after studies, and small numbers of participants. The rapid increase in the use of telehealth in response to the Coronavirus disease 2019 (COVID-19) pandemic is likely to produce more data and offer opportunities for more rigorous studies.