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Dissertations / Theses on the topic 'CGAP'

Author: Grafiati

Published: 5 June 2025

Last updated: 15 July 2025

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1

Ferreira, Joana Filipa Dias. "The role of STING on peroxisome-dependent signalling." Master's thesis, Universidade de Aveiro, 2017. http://hdl.handle.net/10773/21999.

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Mestrado em Biomedicina Molecular<br>Viruses are recognized by several cellular sensors from the innate immune system, activating signalling cascades which result in the production of interferons and other cytokines that affect the virus life cycle and hinder spreading to other cells. Although the RIG-I/MAVS and the STING pathways are assumed to signal, respectively, for RNA and DNA viruses, there is still some controversy on how these pathways interact with and influence each other. The interaction between STING and MAVS, previously reported to take place at mitochondria, supports a c

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2

Kotera, Jun. "Studies on Characterization and Tissue Distribution of cGMP-binding cGMP-specific Phosphodiesterase." Kyoto University, 2000. http://hdl.handle.net/2433/181074.

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3

Müllershausen, Florian. "Desensitisierung der NO/cGMP-vermittelten Signaltransduktion." [S.l.] : [s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=968309941.

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4

Voß, Ulrike. "Immunhistochemische Lokalisation der cGMP-stimulierten Phosphodiesterase /." [S.l. : s.n.], 1998. http://www.gbv.de/dms/bs/toc/243260539.pdf.

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5

Tian, Yuehui [Verfasser], and Georg [Gutachter] Nagel. "Characterization of novel rhodopsins with light-regulated cGMP production or cGMP degradation / Yuehui Tian ; Gutachter: Georg Nagel." Würzburg : Universität Würzburg, 2019. http://d-nb.info/1194836224/34.

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6

Yamahara, Kenichi. "Significance and therapeutic potential of the natriuretic peptides/cGMP/cGMP-depnendent protein kinase pathway in vascular regeneration." Kyoto University, 2004. http://hdl.handle.net/2433/147491.

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7

Santos, Paulo Gonçalo Pinto dos. "Expressão e distribuição de CGRP, VEGF e TGF-β na gengiva dos dentes de ratos com periodontite induzida por ligadura: aspectos imunohistoquímicos." Universidade do Estado do Rio de Janeiro, 2009. http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=2233.

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No momento em que há a agressão tecidual e a defesa inata é deflagrada, mediadores químicos são liberados no local afetado. Esses mediadores podem ser de origem celular tais como CGRP, VEGF e TGFß. Os objetivos desta pesquisa foram avaliar a expressão e distribuição de CGRP, TGFß e VEGF na gengiva do primeiro molar inferior esquerdo de rato no 7 e 14 dias após a indução por ligadura; a expressão e distribuição de CGRP, TGFß e VEGF na gengiva do dente contralateral correspondente sem ligadura, no 7 e 14 dias, e se a indução da periodontite por ligadura no dente experimental provoca uma inflamaç

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8

Charles, Joseph William. "Studies On The Molecular Mechanism Of S-Tide Mediated Activation Of Pkg-Iα". ScholarWorks @ UVM, 2019. https://scholarworks.uvm.edu/graddis/1005.

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cGMP-dependent protein kinases (PKG) are key players in intracellular second messenger signaling within many cellular systems throughout the body. Most notably PKG is known for its role in smooth muscle relaxation (Pfeiffer et.al, 1999). The Iα PKG isozyme has been identified as the primary effector of the nitric oxide pathway (and serves to be a novel drug target). To date the overall knowledge of structure and function of PKG is lacking in terms of the mechanisms of activation and the structural orientations that coordinate them. Recently, our laboratory has solved the crystal structure of t

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9

Sheehe, Jessica Lynne. "The A-Site In The Pkg Iα Regulatory Domain Controls Both Cgmp- And Oxidative-Dependent Activation". ScholarWorks @ UVM, 2018. https://scholarworks.uvm.edu/graddis/950.

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The type Iα cGMP-dependent protein kinase (PKG Iα) is an essential regulator of vascular tone and systemic blood pressure. Located in the smooth muscle of resistance vessels, PKG Iα stimulates vasodilation through the phosphorylation of multiple intracellular substrates. Its primary regulator is the small molecule, 3',5'-cyclic guanosine monophosphate (cGMP); however, the Iα isoform can also be activated by oxidation. Despite the established physiological importance of PKG Iα, the structural underpinnings of these two activation mechanisms are largely unknown. The work presented in this disser

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10

Stodola, Marek. "Robotický manipulátor prostředky CGA." Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2019. http://www.nusl.cz/ntk/nusl-401581.

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Conformal geometric algebra is defined in the thesis. Representations of geometric objects and possibilities of their geometric transformations are presented. Conformal geometric algebra is applied to the calculation of forward kinematics of a robotic manipulator UR10 from Universal Robots. It is also applied to determine the position of the machine based on the location and rotation of two cameras. Then it is used in an inverse task, where based on records from the two cameras, dimensions of the UR10 manipulator and possibilities of its movement, the mutual position of these cameras is determ

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11

Wörner, René. "Mechanismen der cGMP-induzierten Relaxation der Mausaorta." [S.l.] : [s.n.], 2006. http://edoc.ub.uni-muenchen.de/archive/00005008.

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12

Prado, Sánchez Judith. "Regulation of neuroinflammation by cGMP-mediated pathways." Doctoral thesis, Universitat Autònoma de Barcelona, 2012. http://hdl.handle.net/10803/96910.

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En el trabajo aquí presentado se investigó la participación de los niveles intracelulares de GMP-cíclico (CMPC) en la regulación de diferentes aspectos de la neuroinflamación. En el primer capítulo hemos observado que los cultivos de astrocitos y de celulas microgliales aisladas de rata expresan la maquinaria necesaria para sintetizar GMPc en repuesta a Péptidos Natriuréticos (PN) y también los enzimas necesarios para degradar el nucleótido. También se investigaron los efectos de la estimulación por PN en la expresión de la proteína pro-inflamatoria iNOS. Hemos observado que el pretratamiento

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13

Antl, Melanie. "Funktionelle Domänen des cGMP-Kinase-Substratproteins IRAG." [S.l. : s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=973383372.

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14

Wörner, René. "Mechanismen der cGMP-induzierten Relaxation der Mausaorta." Diss., lmu, 2006. http://nbn-resolving.de/urn:nbn:de:bvb:19-50086.

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15

Thorsson, Mathilda. "CGRP som läkemedelsmål vid behandling av migrän." Thesis, Linnéuniversitetet, Institutionen för kemi och biomedicin (KOB), 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-73706.

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Bakgrund: Migrän är en neurologisk sjukdom som består av återkommande anfall med måttlig till svår huvudvärk. Andra symtom som är kopplade till migrän är illamående, ljuskänslighet och ljudkänslighet. I Sverige är det cirka 15 % av den vuxna befolkningen som lider utav sjukdomen. Hypotesen idag är att migrän beror på en aktivering av det trigeminovaskulära systemet med en sensibilisering som följd, på grund av en defekt i hjärnan. Calcitonin Gene-Related Peptide (CGRP), en neuropeptid, har visat sig ha en nyckelroll vid uppkomsten av migrän. Förhöjda nivåer av CGRP har bland annat lyckats påvi

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16

Kandepedu, Hemachandra Nishanth. "Synthèse et évaluation de nouveaux squelettes de molécules potentiellement antagonistes du récepteur au CGRP : application à la douleur chronique." Thesis, Clermont-Ferrand 2, 2015. http://www.theses.fr/2015CLF22627.

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Analgésiques opiacés et les antidépresseurs tricycliques (ATC) sont deux grandes classes d'agents thérapeutiques qui sont utilisés pour soulager les symptômes dus au nociception chronique. Mais ces agents chimio thérapeutiques présentent des effets secondaires comme la constipation, dépendance physique plus soulagement de la douleur insuffisante. D'où des complications aggravent la nécessité de concevoir une molécule qui agit sur nouvelle cible en vue de surmonter les effets secondaires causés par la classe dit ci-dessus de médicaments. Pendant ce temps, la distribution du peptide lié au gène

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17

Bernhard, Dominik. "Die Funktion des cGMP-Kinase Substrates IRAG und der Isoformen der cGMP-abhängigen Proteinkinase Typ I im vaskulären System." Diss., lmu, 2007. http://nbn-resolving.de/urn:nbn:de:bvb:19-77720.

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18

Wen, Lai [Verfasser], and Robert [Akademischer Betreuer] Feil. "Generation and characterization of FRET-based cGMP sensor knock-in mice for cGMP imaging / Lai Wen ; Betreuer: Robert Feil." Tübingen : Universitätsbibliothek Tübingen, 2014. http://d-nb.info/1198119799/34.

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19

Barbosa, Pfannes Eva Katharina. "Probing the regulatory mechanisms of the actomyosin system in motile cells." Phd thesis, Universität Potsdam, 2011. http://opus.kobv.de/ubp/volltexte/2012/5781/.

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Actin-based directional motility is important for embryonic development, wound healing, immune responses, and development of tissues. Actin and myosin are essential players in this process that can be subdivided into protrusion, adhesion, and traction. Protrusion is the forward movement of the membrane at the leading edge of the cell. Adhesion is required to enable movement along a substrate, and traction finally leads to the forward movement of the entire cell body, including its organelles. While actin polymerization is the main driving force in cell protrusions, myosin motors lead to the co

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20

Asplund, Persson Anna K. "Pharmacological evaluation of the NO/cGMP signalling system /." Linköping : Linköpings universitet, 2005. http://www.bibl.liu.se/liupubl/disp/disp2005/med919s.pdf.

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21

Woolley, Michael J. "The structure and function of the CGRP receptor." Thesis, University of Warwick, 2014. http://wrap.warwick.ac.uk/66794/.

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G protein-coupled receptors (GPCRs) are a superfamily of membrane proteins that bind to a diverse array of stimuli and are involved in a large number of physiological functions. The family A GPCRs are the largest and most comprehensively studied. The family B GPCRs are a small but important group of receptors (~15 members) that bind to peptide ligands and are involved in physiological processes that include vasodilation, stress, digestion and glucose homeostasis. The CGRP receptor is a unique member of this family as it is a heterodimer consisting of a GPCR subunit (calcitonin receptor-like re

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22

Oliveira, Alessandra Guaracy de. "Implementação do plano projetivo orientado na biblioteca CGAL." [s.n.], 2004. http://repositorio.unicamp.br/jspui/handle/REPOSIP/276448.

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Orientador: Pedro J. de Rezende<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Computação<br>Made available in DSpace on 2018-08-04T19:09:13Z (GMT). No. of bitstreams: 1 Oliveira_AlessandraGuaracyde_M.pdf: 3073500 bytes, checksum: 2795c9b64015430b6a77162d260d2f2a (MD5) Previous issue date: 2005<br>Resumo: CGAL (Computational Geometry Algorithms Library) é uma biblioteca de estruturas de dados e algoritmos geométricos confiáveis que vem sendo desenvolvida de forma cooperativa por um consórcio formado por instituições na Europa e em Israel. Os algoritmos de CGAL es

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23

Gallinari, Marjorie de Oliveira [UNESP]. "Influência do peróxido e do uso de diferentes substâncias de combate à dor na inflamação e na expressão de neuropeptídeos pró-inflamatórios após o tratamento clareador." Universidade Estadual Paulista (UNESP), 2016. http://hdl.handle.net/11449/138849.

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Submitted by MARJORIE DE OLIVEIRA GALLINARI null (marjo_oliveira@hotmail.com) on 2016-05-20T00:08:43Z No. of bitstreams: 1 Versão final - Diessertação!.pdf: 4298608 bytes, checksum: d78e89bc5d747df80a571cc21dbf5c26 (MD5)<br>Approved for entry into archive by Felipe Augusto Arakaki (arakaki@reitoria.unesp.br) on 2016-05-23T19:19:29Z (GMT) No. of bitstreams: 1 gallinari_mo_me_arafo.pdf: 4298608 bytes, checksum: d78e89bc5d747df80a571cc21dbf5c26 (MD5)<br>Made available in DSpace on 2016-05-23T19:19:29Z (GMT). No. of bitstreams: 1 gallinari_mo_me_arafo.pdf: 4298608 bytes, checksum: d78e89bc5d74

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24

Taylor, Gillian Marie. "Actions of adrenomedullin and characterisation of receptors mediating these actions in the rat." Thesis, Imperial College London, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.312987.

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25

Assender, Jean W. "Control of vascular smooth muscle cell proliferation by cyclic nucleotides." Thesis, Cardiff University, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.389966.

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26

Koller, Angela. "Identifizierung und Funktion von Effektorproteinen der NO/cGMP Signalkaskade." Diss., lmu, 2002. http://edoc.ub.uni-muenchen.de/219/.

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27

Grosser, Nina. "Endothelprotektion durch Acetylsalicylsäure Stickstoffmonoxid und cGMP als antioxidative Mediatoren /." [S.l.] : [s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=967136032.

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28

Geiselhöringer, Angela. "Interaktion und Gewebeverteilung von Komponenten des cGMP-Kinase Signalweges." [S.l.] : [s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=966111958.

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29

Hauptmann, Peter Hans. "Komponenten des cGMP-Systems im Corpus pineale des Menschen." [S.l.] : [s.n.], 2005. http://deposit.ddb.de/cgi-bin/dokserv?idn=974208701.

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30

Kügler, Robert [Verfasser]. "Visualization of cGMP signaling in the prostate / Robert Kügler." Gießen : Universitätsbibliothek, 2019. http://d-nb.info/1187132497/34.

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31

Tucci-Viegas, Vanina Monique [UNIFESP]. "CGRP e SP em cultura de fibroblastos de queloide." Universidade Federal de São Paulo (UNIFESP), 2011. http://repositorio.unifesp.br/handle/11600/21613.

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Made available in DSpace on 2015-12-06T23:44:51Z (GMT). No. of bitstreams: 0 Previous issue date: 2011<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)<br>Introdução: Sabendo-se que o estímulo neurogênico de origem nociceptiva é considerado o deflagrador primário do processo de cicatrização da pele, que o CGRP e SP aumentam a proliferação de fibroblastos in vitro, e diante da falta de estudos correlacionando CGRP, SP e p53 e apoptose em queloide torna-se importante investigar se os neuropeptídeos da pele podem influenciar a expressão de p53 e a apoptose no queloi

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32

Silvério, Vanessa Kovalski. "EFEITO DO SILDENAFIL SOBRE ALTERAÇÕES VASCULARES E DANO TECIDUAL INDUZIDOS PELO CHOQUE SÉPTICO." UNIVERSIDADE ESTADUAL DE PONTA GROSSA, 2015. http://tede2.uepg.br/jspui/handle/prefix/98.

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Made available in DSpace on 2017-07-21T14:13:07Z (GMT). No. of bitstreams: 1 Vanessa Kovalski Silverio.pdf: 1423306 bytes, checksum: 68729da0a75b158004d6a33911081b96 (MD5) Previous issue date: 2015-02-26<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>Septic shock, which is triggered by microbial products, is mainly characterized by an inadequate tissue perfusion caused by a decreased in blood pressure, vascular damage, hyporeactivity to vasoconstrictors and disseminated intravascular coagulation, which can lead to multiple organ dysfunction and death. Nitric oxide (NO) is

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33

Cameron, Smail Ruaridh. "Axonal excitability in sporadic migraine." Thesis, The University of Sydney, 2020. https://hdl.handle.net/2123/26808.

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Migraine is a common yet debilitating condition worldwide, affecting individuals, particularly women, of working age, causing significant impacts on quality of life and productivity. In this study, we set out to evaluate a group of individuals with sporadic migraine. We aimed to evaluate the effect of botulinum toxin or the novel calcitonin gene-related peptide (CGRP) erenumab. We were also able to consider studies on patients with familial hemiplegic migraine, where we were particularly looking to see if there were alterations in axonal excitability related to the gene mutations. A study ha

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34

Smital, Petra Angelika. "IRAG als funktionales Element der NO/cGMP Signalkaskade im Gastrointestinaltrakt." Diss., lmu, 2006. http://nbn-resolving.de/urn:nbn:de:bvb:19-56277.

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35

Chu, Ka Man Emily. "Desensitisation of the CGRP receptor in SK-N-MC cells." Thesis, Queen Mary, University of London, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.487319.

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Calcitonin gene-related peptide (CORP) and adrenomedullin (AM) are potent vasodilators that activate the calcitonin-like receptor complexed with one of three receptor activity modifying proteins (RAMP1 for CORP, RAMP 2/3 for AM). Desensitisation of these receptors was characterised in the human neuroblastoma SK-NMC cell line. Desensitisation was dose-dependent (ICso values: CORP, 2.92 x 10-7 M; AM, 1.08 x 10-7 M) and time-dependent, being maximal with a 2-hour agonist pretreatment. Inhibitor experiments showed that CORP-induced desensitisation was independent of protein kinase A (H-89) but was

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36

Herring, Neil. "NO-cGMP signalling in the cholinergic modulation of cardiac excitability." Thesis, University of Oxford, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.393393.

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37

Tomlinson, Ann E. "Characterisation of calcitonin gene-related peptide (CGRP) and amylin receptors." Thesis, Aston University, 1995. http://publications.aston.ac.uk/14312/.

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The aims of this study were to examine the binding characteristics of the rat CGRP receptor and to further the classification of CGRP and amylin receptors in guinea-pig tissue preparations. Binding characteristics of CGRP were investigated on rat splenic, cerebellar and liver membrane preparations. Human-a-CGRP, rat-a-CGRP and the CGRP receptor analogues TyrO -CGRPC28-37) and [Cys (ACMh,7 ]-human CGRP and the CGRP receptor antagonist CGRPC8-37) were utilised in competitive radioligand binding experiments to identify possible CGRP receptor subtypes in these tissues. There appeared to be no sign

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38

Sekharan, Monica R. "Structural studies of the cGMP-binding GAF domain of PDE5A /." Thesis, Connect to this title online; UW restricted, 2004. http://hdl.handle.net/1773/8502.

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39

Huang, Daming. "Molecular determinants of cGMP-binding to chicken cone photoreceptor phosphodiesterase /." Thesis, Connect to this title online; UW restricted, 2004. http://hdl.handle.net/1773/5095.

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40

Hopp, Christine S. "Functional analysis of the plasmodium falciparum cGMP-dependent protein kinase." Thesis, London School of Hygiene and Tropical Medicine (University of London), 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.549762.

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41

Dumoulin, Alexandre [Verfasser]. "cGMP signalling regulates S-palmitoylation in sensory neurons / Alexandre Dumoulin." Berlin : Freie Universität Berlin, 2017. http://d-nb.info/1144270227/34.

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42

Hussin, Norriza. "Evidential analysis for computer-generated animation (CGA)." Thesis, University of Nottingham, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.431184.

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43

L'Herondelle, Killian. "Etude sur neurones sensoriels et kératinocytes des mécanismes cellulaires et moléculaires impliqués dans le prurit de la ciguatéra." Thesis, Brest, 2016. http://www.theses.fr/2016BRES0115.

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La ciguatéra est une forme d’intoxication faisant suite à l’ingestion de poissons contaminés par des toxines appelées « ciguatoxines ». Cette intoxication endémique des régions tropicales est un problème économique et de santé non négligeable qui tend à prendre de plus en plus d’ampleur. L’essor du tourisme, le réchauffement climatique et la hausse des exportations internationales de poissons tropicaux favorisent l’expansion de la ciguatéra aux parties du globe au climat tempéré, jusqu’alors peu concernées par cette maladie. Les enjeux thérapeutiques et économiques de la ciguatéra sont de tail

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44

Wanschoor, Paul. "Impact de la déficience de NEIL1 sur l'inflammation médiée par la voie des senseurs des ADNs cytosoliques." Electronic Thesis or Diss., université Paris-Saclay, 2024. http://www.theses.fr/2024UPASL032.

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Des recherches récentes ont établi des liens essentiels entre les dommages à l'ADN, le stress réplicatif et l'inflammation, révélant ainsi un mécanisme complexe dans lequel les fragments d'acides nucléiques résultants sont exportés dans le cytosol. Une fois dans le cytosol, ces fragments peuvent être détecté par des senseurs cellulaires tels que cGAS et RIG1, qui, avec l'aide respective de STING ou MAVS, déclenche la production de cytokines inflammatoires et l'activation des réponses immunitaires innées ou des voies de la mort cellulaire. Cette découverte souligne l'importance cruciale des voi

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45

Bressac, Florent. "Dynamique nucléaire de cGAS lors de la sénescence induite par des dommages à l’ADN." Electronic Thesis or Diss., Lyon 1, 2024. http://www.theses.fr/2024LYO10258.

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Les cellules des organismes eucaryotes sont soumises à des divisons qui augmentent le risque de mutations au fur et à mesures de celles-ci, et à divers stress pouvant endommager l’ADN. Afin d’éviter la transformation tumorale des cellules, ces dernières peuvent entrer en sénescence, un état qui permet l’arrêt irréversible du cycle cellulaire. Ce processus antitumoral est également impliqué dans le développement embryonnaire, la cicatrisation et l’apparition de maladies liées au vieillissement. La régulation de la mise en place de cet état fait intervenir de nombreux acteurs cellulaires, notamm

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46

Harzenetter, Marit Daniela. "Funktionen des Neuropeptids CGRP bei der neuronalen Kontrolle des hämatopoetischen Systems." [S.l.] : [s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=970955308.

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47

Schobesberger, Sophie. "Changes in cardiomyocyte structure and cAMP/cGMP signalling during heart failure." Thesis, Imperial College London, 2015. http://hdl.handle.net/10044/1/34341.

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The contractile function of the heart depends on efficient β adrenergic receptor (βAR) signalling which involves cycling nucleotides as second messengers. Correct secondary messenger signalling is only possible in healthy, well structured cardiac myocytes. Of the three βAR subtypes present in human cardiomyocytes β1AR and β2AR classically signal via 3'-5' cyclic adenosine monophosphate (cAMP) to regulate contraction after catecholamine administration, whereby the second isoform may also be cardioprotective. The far less characterised β3AR has been controversially associated to both increasing

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48

Nixon, Douglas A. "A seventeenth-century house at Ferryland, Newfoundland (CgAf-2, Area B)." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp01/MQ54944.pdf.

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49

Fabritius, Arne [Verfasser], and Oliver [Akademischer Betreuer] Grisbeck. "Novel genetically encoded biosensors for cGMP / Arne Fabritius ; Betreuer: Oliver Grisbeck." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2016. http://d-nb.info/1173087583/34.

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50

Russell, Mark A. "Characterization of FTO and cGMP signalling in clonal pancreatic B-cells." Thesis, University of Exeter, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.530387.

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