Relevant bibliographies by topics / CGEN

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Academic literature on the topic 'CGEN'

Author: Grafiati
Published: 4 June 2021
Last updated: 1 February 2022

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Journal articles on the topic "CGEN"

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Chen, Haiming, Mingjie Li, Jennifer Li, Marissa P. Dreyer, Cameryn P. Ahles, Tiffany Lee, Joleen T. Qiu, et al. "Blockage of CGEN-928 Expression Down-Regulates AKT Signaling Pathway and Inhibits Multiple Myeloma (MM) Cell Proliferation." Blood 118, no. 21 (November 18, 2011): 5102. http://dx.doi.org/10.1182/blood.v118.21.5102.5102.

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Abstract Abstract 5102 We have recently reported that CGEN-928 is highly expressed on the cell membrane of cell lines, human xenografts, and primary tumor cells from MM. Anti-CGEN-928 (anti-TM21) polyclonal antibody blocked the expression of CGEN-928 which decreased MM tumor cell proliferation and increased apoptosis in the MM cell lines MM1s, RPMI8226 and U266 as well as primary MM tumor cells. The mechanism through which blocking CGEN-928 decreases MM tumor cell proliferation and enhances apoptosis has not been elucidated clear. In this study, a CGEN-928 shRNA (lentiviral particles) was used to silence this gene's expression, and determine its impact on the AKT signal transduction pathway which has been shown to play an important role in MM tumor cell metabolism proliferation, and survival. Briefly, MM1s or primary MM tumor cells were cultured in a 12-well plate for 24 hours prior to the viral infection. On the following day, a mixture of 5ug/ml Polybrene and fresh medium were added to the cells. The CGEN-928 shRNA lentiviral particles were then added to the culture. While transducing cells, we treated a portion of the cells with a negative control through introduction of control shRNA lentiviral particles. To ensure we achieved a successful transduction, we also treated another portion of the cells with cop GFP control Lentiviral particles. We confirmed that 75% of MM cells were transduced based on GFP+ cell counts after 24 hours treatment. The day following the transduction, the cultured medium was removed and replaced with fresh medium without polybrene. Two days following transduction, we used fresh 10ug/ml puromycin-containing medium to select stable MM cells. We replaced the medium with fresh puromycin-containing medium every three days until resistant MM tumor cells were stable. Proliferation rate of the MM1s tumor cells transduced with CGEN-928 shRNA (85%) 24 hours was much lower than the tumor cells transduced with control lentiviral particles rate (170%). The proportion of MM cells undergoing apoptosis treated with CGEN-928 shRNA (42%) was higher than MM cells transduced with control lentiviral particles (13%). We next examined several protein phosphorylation sites related to AKT signaling pathway by Western blot. The results showed AKT1 phosphorylation in MM tumor cells transduced with CGEN-928 shRNA or anti- CGEN-928 polyclonal antibody was decreased and phosphorylation of c-Raf, GSK-3β, factors downstream of AKT were also down-regulated. PTEN phosphorylation slightly decreased in MM cell treated with anti-CGEN-928 antibody but did not change in MM cells silenced with CGEN-928 shRNA. We further examined downstream gene expression of the AKT pathway when CGEN-928 was silenced using siRNA or the anti-CGEN-928 TM-21 antibody. We found AKT1 gene expression was reduced in the presence of CGEN-928 siRNA or antibody but it did not impact ATK2 and AKT3. mTOR gene expression in MM tumor cells was decreased with exposure to CGEN-928 siRNA but anti-TM21 showed no effect. Cyclin D1 gene expression in MM tumor cell was not affected by CGEN-928 siRNA and antibody. These studies suggest that blockage of CGEN-928 antigen expression inhibits MM tumor cell proliferation and enhance tumor cell apoptosis through AKT signaling pathway. Currently, a monoclonal anti-CGEN-928 antibody is in development that will be used by our group to evaluate its anti-MM effects both in vitro and in vivo using our SCID-hu models of human MM. Disclosures: Berenson: Novartis: Consultancy, Honoraria, Research Funding, Speakers Bureau; Millennium Pharmaceuticals, Inc.: Consultancy, Honoraria, Research Funding, Speakers Bureau; Onyx Pharmaceuticals: Consultancy, Honoraria, Research Funding, Speakers Bureau; Celgene: Consultancy, Honoraria, Research Funding, Speakers Bureau; Medtronic: Consultancy, Honoraria, Research Funding, Speakers Bureau; Merck: Research Funding; Genentech: Research Funding.
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Chen, Haiming, Mingjie Li, Cathy Wang, Jessica Wang, Eric Sanchez, Zhi-Wei Li, Benjamin Bonavida, et al. "Multiple Myeloma (MM) Highly Expresses CGEN-928 and the Anti-CGEN-928 TM21 Antibody Markedly Inhibits the Growth of MM Cells and Enhances the Anti-Myeloma Effects of Dexamethasone, Melphalan and Bortezomib." Blood 116, no. 21 (November 19, 2010): 4067. http://dx.doi.org/10.1182/blood.v116.21.4067.4067.

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Abstract Abstract 4067 Although patients with multiple myeloma (MM) initially respond to current treatment modalities, it remains an incurable disease. Many new therapeutic options have become available during the past several years but nearly all patients develop resistance to currently available therapeutic options. In addition, there is no tumor marker that is uniformly expressed in all MM cells although CD138 is considered to be present on the surface of tumor cells in most cases of MM but generally is only present in a subset of the patients' tumor population and may be absent in the most resistant part of the tumor clone. In order to address these unmet clinical needs, we queried Compugen's MED Platform, an expression database which covers over 40,000 microarray experiments, for genes overexpressed in B cell-derived malignancies including MM and that exhibit low expression levels in normal cells and tissues. One of the most prominent candidates was CGEN-928, which was validated as over-expressed in MM at the mRNA level using an independent panel of both hematological malignancies and normal tissues. In this study, we first investigated whether the previously unidentified membrane antigen CGEN-928 is expressed in cells from human MM cell lines, human MM xenografts and fresh bone marrow (BM) aspirates derived from MM patients using flow cytometric analysis and immunohistochemical staining with the anti-CGEN-928 TM21 polyclonal antibody (Compugen Ltd, Tel Aviv, Israel). Using this antibody, we found that CGEN-928 was highly expressed in cells from the MM1s, U266 and RPMI8226 MM cell lines. Next, we examined CGEN-928 antigen expression in fresh tumor cells from BM aspirates from 17 MM patients and also showed high expression of CGEN-928. Notably, expression of this antigen was not only found on CD138+ MM cells but also on MM tumor cells lacking CD138 expression. We also examined the expression of CGEN-928 using our human MM xenograft models LAGκ-1A (bortezomib-sensitive), LAGκ-1B (bortezomib-resistant) and LAGλ-1 (melphalan-resistant). The bortezomib-sensitive MM tumor LAGκ-1A expresses CD138 whereas the bortezomib-resistant version LAGκ-1B developed from the same patient after the patient developed bortezomib reisistance does not express CD138. Cells from all three tumor types showed high levels of reactivity with the TM21 antibody. Similar to the fresh MM BM samples, CGEN-928 expression was not only found on CD138+ MM cells but also on CD138- tumor cells derived from these human MM xenografts. Because this molecule is highly expressed on MM cells, we hypothesized that the anti-CGEN-928 antibody may show anti-MM effects and enhance the anti-MM effects of other anti-MM drugs. To evaluate this, we examined the effect of the TM21 antibody alone and in combination with dexamethasone, melphalan and bortezomib in vitro using cell proliferation MTT assays. Anti-TM21 polyclonal antibody (100 mg/ml) decreased MM tumor cell proliferation and increased apoptosis in cells from the MM1s, RPMI8226 and U266 cell lines. Next, we determined the effects of combining the anti-CGEN-928 antibody with bortezomib, melphalan or dexamethasone on MM1s cells. Cell proliferation assays demonstrated marked enhanced anti-proliferative effects when CGEN-928 antibody at concentrations of 5, 10, 50 and 100 mg/ml was combined with bortezomib, melphalan or dexamethasone. Further investigations are defining the mechanisms and signal transduction pathways that produce the anti-MM effects of CGEN-928. These preliminary studies suggest that the CGEN-928 antigen is highly expressed in MM and treatment with an anti-CGEN-928 polyclonal antibody produces anti-MM effects alone and in combination with other anti-MM agents; and thus, this antigen may be a target for the treatment of multiple myeloma. Currently, a monoclonal anti-CGEN-928 antibody is in development that will be used by our group to evaluate its anti-MM effects both in vitro and in vivo using our SCID-hu models of human MM. Disclosures: Levy: Compugen Ltd.: Employment. Dassa:Compugen Ltd.: Employment. Cojocaru:Compugen Ltd.: Employment. Berenson:Compugen Ltd.: Research Funding. Levine:Compugen Ltd.: Employment.
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Møller, Pål, and Neal Clark. "CGEN-A clinical GENetics software application." Human Mutation 32, no. 5 (March 8, 2011): 537–42. http://dx.doi.org/10.1002/humu.21452.

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Tomchinsky, Bernardo, Lin Chau Ming, Ari De Freitas Hidalgo, Izabel De Carvalho, and Carolina Weber Kffuri. "IMPACTOS DA LEGISLAÇÃO NA PESQUISA ETNOBOTÂNICA NO BRASIL, COM ÊNFASE NA REGIÃO AMAZÔNICA." Amazônica - Revista de Antropologia 5, no. 3 (May 7, 2014): 734. http://dx.doi.org/10.18542/amazonica.v5i3.1603.

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A região amazônica possui uma grande sociobiodiversidade, com povos detentores de conhecimentos tradicionais sobre os usos de seus recursos naturais. Com a Convenção sobre a Diversidade Biológica (CDB) em 1992, foi reconhecida a autonomia de cada nação sobre seu patrimônio genético e o direito das populações tradicionais sobre o uso e conhecimento destes recursos naturais. Em 2001 foi editada a Medida Provisória 2.186-16/2001 que criou o Conselho Nacional de Gestão do Patrimônio Genético (CGEN) e as primeiras regras sobre o acesso ao patrimônio genético e ao conhecimento tradicional associado no Brasil. Desde sua criação, as ações do CGEN têm recebido críticas de vários setores, tanto privados quanto públicos e, ao contrário de sua proposta inicial, tem se constituído em um dos principais entraves das pesquisas etnobotânicas, pela burocracia, pelo longo período de análise dos processos, e pela dificuldade de comunicação com este órgão. Palavras-chave: legislação, biodiversidade, acesso ao patrimônio genético, conhecimento tradicional associado, etnobotânica, Amazônia.
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Aboal López, María. "Reflejo y construcción de la mujer decimonónica en "la ilustración española y americana"." Comunicación y Género 2, no. 1 (July 3, 2019): 65–86. http://dx.doi.org/10.5209/cgen.64945.

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La prensa del Ochocientos nos ofrece la posibilidad de observar la evolución social de la mujer en una época en la que se produjo la consolidación del periodismo y el florecimiento de la prensa ilustrada y de la prensa femenina. A través de una de las revistas ilustradas más representativas del período restaurador, La Ilustración Española y Americana (1869-1921), propongo responder a una pregunta: ¿qué es lo que leían las mujeres burguesas en la prensa de aquella época para convertirse en una Emma Bovary o en una Ana Ozores? Las mujeres eran un nuevo público lector al que las publicaciones comenzaban a tener muy en cuenta. ¿A qué estaban expuestas como objeto comercial y social?
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Díaz Hernández, José Andrés. "Virginie Despentes. 'Teoría King Kong'. Barcelona, Editorial Penguin Random House, colección Literatura, nueva edición de 2018, 175 págs. ISBN: 9788439733997 (tapas blandas). Traducción directa del francés de Paul B. Preciado." Comunicación y Género 2, no. 2 (November 20, 2019): 267–74. http://dx.doi.org/10.5209/cgen.65304.

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Saneleuterio, Elia, and Rocío López-García-Torres. "Cuestiones de género y ciudadanía en el discurso fílmico." Comunicación y Género 2, no. 2 (November 20, 2019): 147–59. http://dx.doi.org/10.5209/cgen.66507.

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El cine y la ficción seriada, incluida la animación, son transmisores de modelos, de actitudes, de valores y normas de conducta que son replicados, consciente e inconscientemente, por la ciudadanía, al mismo tiempo que la reflejan. Esta doble vertiente de causa y consecuencia de los patrones sociales existentes explica el interés de la comunidad científica por determinar en qué medida mantienen los prejuicios y en qué medida laboran en su superación. Por ello se abordan en este volumen obras fílmicas, en su mayoría protagonizadas por mujeres, con metodologías de análisis que beben del feminismo, que trascienden la mirada masculina y que encaran la problemática de la agencia de los personajes de ficción.
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Russo, Michela. "Devolver la mirada: el personaje de Vera en 'La piel que habito' de Pedro Almodóvar." Comunicación y Género 2, no. 2 (November 20, 2019): 161–82. http://dx.doi.org/10.5209/cgen.66508.

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Este ensayo analiza la dialéctica entre mirada masculina y mirada femenina en el cine a través del análisis del personaje de Vera en La piel que habito (2011) de Pedro Almodóvar. El movimiento de la cámara, sus ángulos y tomas materialmente establecen la mirada que estructura una película y construye a sus personajes. Consideramos la noción de mirada masculina desarrollada por Laura Mulvey en 1970, como una mirada que corresponde al placer masculino objetivador. Suplementamos esta noción con la definición de mirada femenina desarrollada por Jill Soloway, como un intento de contrastar esta perspectiva. A través de Vera, que es un personaje transexual, Almodóvar exacerba esta dialéctica entre miradas hasta romperla, a la vez tematizando una noción de feminidad más amplia capaz de instituir una mirada queer.
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Martínez Istillarte, Cristina. "María Egipciaca y 'Breaking the Waves': la irresistible atracción de la prostituta mártir." Comunicación y Género 2, no. 2 (November 20, 2019): 183–91. http://dx.doi.org/10.5209/cgen.66509.

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La vida de María Egipciaca ha sido por siglos imaginada y diseminada a mano de un notable puñado de hombres, en su mayoría miembros del clero, con propósitos correspondientes. Dentro de dicho corpus literario se evidencia toda una manera de escribir sobre conversiones de mujeres, espacio donde se idealiza el sacrificio corporal femenino y, por ende, promueve imágenes e ideas esencialistas sobre la mujer y/o lo femenino. Este estudio analiza la intertextualidad entre la leyenda de María Egipciaca y el filme Breaking the Waves (1996), del director danés Lars Von Trier, cuya protagonista —aquí se propone— es eco directo de María Egipciaca.
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Pastor, Brígida M. "Pride and Prejudice: Fashioning a Cuban Discourse of 'Difference' in 'Fresa y Chocolate'." Comunicación y Género 2, no. 2 (November 20, 2019): 193–209. http://dx.doi.org/10.5209/cgen.66510.

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El cine ha surgido como un foco de producción en el que las representaciones de las sexualidades se construyen e inscriben dentro del discurso simbólico del poder y la película cubana Fresa y chocolate representa un ejemplo esclarecedor. El objetivo de Gutiérrez Alea y Juan Carlos Tabío es hacer explícita la construcción social del orden simbólico dominante y los problemas involucrados en su deconstrucción, para mostrar hasta qué punto la política sexual está profundamente arraigada en todas las formaciones culturales y sociales a lo largo de la historia. Este estudio intenta dilucidar la relación dialéctica entre el orden simbólico social —la norma— y la conciencia individual. Los cineastas construyen estratégicamente la relación y los conflictos y contradicciones que surgen de ella, incluida la crítica de algunos aspectos de la Revolución Cubana, a saber, el pathos de la cultura queer, lo que potencia la diferencia sexual como un elemento de cambio social.
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Dissertations / Theses on the topic "CGEN"

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Fraxe, Jaiza Maria Pinto. "Do geodireito ao Conselho de Gestão do Patrimônio Genético CGEN: caminhos e instrumentos de gestão do conhecimento biotecnológico na Amazônia." Universidade Federal do Amazonas, 2011. http://tede.ufam.edu.br/handle/tede/3086.

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Made available in DSpace on 2015-04-20T12:31:29Z (GMT). No. of bitstreams: 1 Jaiza Maria Pinto Fraxe.pdf: 1743018 bytes, checksum: 6d8b9d82b71d72005e324a3238622586 (MD5) Previous issue date: 2011-11-17
The Genetic Heritage Management Council (CGEN), is part of the Brazilian Environment Ministry MMA and was created by the MP 2.186-16 to serve as a deliberative and normative organism, an active voice for the protection of the native genetic patrimony, restoration of the environment and the sustainable use of natural resources. It is comprised of representatives from other Brazilian ministries, entities of the Federal Administration, besides representatives from the civil society and prosecutors. The CGEN is responsible for addressing the following issues: authorization for access to the genetic patrimony and research involving traditional knowledge of native populations, associated with genetic patrimony. In view of the complexity of the demands imposed by CGEN to meet the requirements of the regulatory framework and considering its eight years of existence this work was conducted aiming at assessing the past accomplishments of this council and impacts caused thereby. Additional approaches were carried out to investigate the pathways to be followed to adapt the so called Geodireito to the everyday facts and phenomena related to bioprospection of genetic resources in Brazil as well as exploitation of traditional knowledge of forest peoples. The methodological strategy adopted was based on theoretical and methodological paradigms of scientific research supported by dogmatic and non dogmatic principles provided by the legal system; principles from the positive law and from the nacional and foreign legal doctrines which are rooted on bioethics, anthropology, sociology, geography and mainly on biotechnology principles. Semi-structured interviews and oral testimony besides intensive literature revision were used as research tools for data collection. The ultimate goal of this work was contributing to expand discussions on the ethical and legal limits imposed to the advance of life science researches and to the sustainable exploitation of natural resources in the Amazon
O CGEN - Conselho de Gestão do Patrimônio Genético, órgão de caráter deliberativo e normativo criado pela MP 2.186-16 no âmbito do Ministério do Meio Ambiente - MMA, é integrado por representantes de diversos Ministérios, órgão e entidades da Administração Pública Federal, representantes da sociedade civil e Ministério Público. Dentre as competências do CGEN está a responsabilidade para emissão de autorização para pesquisas que envolvam o conhecimento tradicional associado ao patrimônio genético nacional. Diante da complexidade de ações que devem ser perpetradas para atender os requisitos do marco legal disciplinado por este órgão, o presente trabalho se propõe a pesquisar os caminhos multidisciplinares das pesquisas a serem percorridos diante do CGEN, em face da necessidade de adaptação do Geodireito ao estado de fatos e fenômenos cotidianos ligados à bioprospecção de recursos genéticos existentes no território brasileiro, bem como à exploração dos conhecimentos tradicionais dos povos da floresta. A metodologia está amparada no propósito dos paradigmas teórico-metodológicos de investigação científica, que se sustentam em princípios dogmáticos e não-dogmáticos, obtidos através do sistema jurídico, do direito positivo e da doutrina nacional e estrangeira, enquanto estes últimos se fundamentam em estudos da Bioética, Filosofia, Antropologia, Sociologia, Geografia e, sobretudo, Biotecnologia. Foi utilizada como instrumento de pesquisa a entrevista semi-estruturada. Tal investigação objetiva, finalmente, contribuir para a ampliação do debate argumentativo em torno dos limites ético-jurídicos impostos aos avanços das ciências da vida e da exploração sustentável de recursos naturais na Amazônia
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Savergnini, Silvia Silveira Quintao. "Avaliação dos efeitos cardiovasculares do novo agonista do receptor MAS, CGEN 856S." Universidade Federal de Minas Gerais, 2011. http://hdl.handle.net/1843/ICBD-8LRJEU.

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The increasing evidence of the beneficial effects of Angiotensin-(1-7) [Ang-(1- 7)] through the activation of its receptor Mas, as vasodilation, antiarrhythmogenesis, antitrombogenesis, antifibrogenesis, improvement of erectile dysfunction and lipdic and glicemic metabolism, raised the possibility to develop new drugs based on the ACE2/Ang-(17)/Mas axis. Advances in biotechnology allowed the discovery of a potential Mas agonist, CGEN-856S. This was achieved using a computational biology platform, developed by the biotechnology company Compugen, for predicting novel naturally occurring peptides that may activate G protein-coupled receptors. CGEN-856S was found to activate the Mas receptor, in a cell-based system (Shemesh et al., 2008). In this study we evaluated the cardiovascular effects of this potential Mas agonist, intending to clarify its specificity in binding Mas. CGEN-856S induced an endothelium- and NO-dependent vasodilating effect in aorta rings of mice and rats. The relaxing effect of CGEN-856S was mediated by Mas, as indicated by the lack of action in Mas knockout aortic rings and inhibition by the Mas antagonist, A-779. Our data also show the antiarrhythmogenic effect of CGEN-856S (0,04 nmol/L) in isolated rat hearts. This effect was followed by an improvement of the systolic and diastolic tension during reperfusion, without alterations on the heart rate. CGEN-856S also produced cardio-protection in the isoproterenol-induced heart remodeling model, as demonstrated by a reduction in collagen I, III and fibronectin staining, as well as an anti-hypertrophic effect. The acute (i.v.) and chronic (28 days) administration of CGEN-856S in spontaneously hypertensive rats produced a marked decrease in mean arterial pressure. Radioligand binding competition assay showed that CGEN-856S did not activate AT1 or AT2 Ang II receptors. On the other hand, the CGEN-856S induced an effective displacement of the FAM-Ang-(1-7) binding to CHO Mas-transfected cells. Furthermore, infarcted animals treated with the novel Mas agonist, presented an improvement of cardiac function and a reduction in myocardial infarcted area. These results reinforce the increasing evidence of a key role of Mas in the cardiovascular system. The discovery of CGEN-856S as a novel Mas agonist, might has a therapeutic value and represents an important step for exploration of the effects mediated by Mas and of its potential as a cardiovascular drug target
Devido à crescente evidência dos efeitos benéficos promovidos pelaAngiotensina-(1-7) [Ang-(1-7)] via receptor Mas, entre eles vasodilatação, antiarritmogênese, anti-trombogênese, anti-fibrogênese, facilitação da função erétil e melhora do metabolismo glicêmico e lipídico, o eixo ECA2/Ang-(1-7)/Mas é, atualmente, um alvo potencial para novas abordagens terapêuticas de doenças cardiovasculares. Recentes avanços em biotecnologia permitiram a descoberta de um potencial agonista do Mas, o CGEN-856S. Isto foi possível através da utilização de uma plataforma biológica computacional, desenvolvida pela empresa de biotecnologia Compugen, usada para identificar novos peptídeos ligantes de receptores acoplados à proteína G. A capacidade do CGEN-856S ativar o receptor Mas foi demonstrada pela indução do influxo de cálcio em células CHO-K1 cotransfectadas com o Mas (Shemesh et al., 2008). Neste estudo, avaliamos os efeitos cardiovasculares deste novo peptídeo, assim como sua especificidade de ligação ao Mas. Nossos dados mostram que o CGEN-856S induziu um efeito vasodilatador dependente do endotélio e da produção de óxido nítrico, em anéis de aorta de ratos e camundongos. O efeito relaxante do CGEN-856S foi mediado pela interação com o receptor Mas, como indicado pela inibição da resposta vasodilatadora na presença do A-779 e em anéis de aorta de camundongos KO-Mas. Nossos dados também mostram o efeito anti-arritmogênico induzido pelo CGEN-856S (0,04 nmol/L) em corações isolados de rato. Este efeito foi seguido de melhora da função cardíaca, observada pela preservação da tensão sistólica e diastólica durante a reperfusão, sem alterações na frequência cardíaca. Através da utilização do modelo de hipertrofia cardíaca induzida pelo isoproterenol, observamos que o CGEN-856S reduziu a deposição de colágeno I, III e fibronectina no coração, além de produzir efeito anti-hipertrófico. Além disso, a administração aguda (i.v.) e crônica (28 dias) do novo agonista do Mas produziu uma redução da pressão arterial em ratos espontaneamente hipertensos. Ensaios de competição de radioligante mostraram que o CGEN-856S possui baixa afinidade pelos receptores de angiotensina II, AT1 e AT2. Interessantemente, o composto CGEN-856S deslocou a ligação da FAM-Ang-(1-7) em células CHO transfectadas com o Mas. Finalmente, o papel cardioprotetor vido novo agonista do Mas, CGEN-856S, foi também observado no odelo de insuficiência cardíaca induzida pela oclusão da artéria coronária esquerda. O tratamento com o novo peptídeo preservou a função cardíaca pós-isquêmica de ratos infartados, além de reduzir a área de infarto. Estes resultados reforçam a crescente evidência de um papel chave do receptor Mas na função cardiovascular. A descoberta do CGEN-856S como um novo agonista do Mas representa um passo importante para a exploração das ações deste receptor e para a validação de seu potencial como alvo terapêutico em patologias cardiovasculares
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Peluso, Antonio Augusto Bastos. "Efeito comparativo entre a angiotensina-(1-7) e o novo agonista do receptor MAS, CGEN 856S, nas vias AKT/eNOS e AKT/FOXO1 utilizando modelos celulares." Universidade Federal de Minas Gerais, 2014. http://hdl.handle.net/1843/BUBD-9NBKEF.

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Biotechnology studies based on a computational platform developed by Compugen, Tel Aviv, Israel - allowed the discovery of a potential Mas agonist, CGEN 856S, which produces several effects resembling those produced by Angiotensin-(1-7) [Ang-(1-7)], including anti-hypertensive and cardioprotective effects, such as decrease of ischemia, renal and cardiac fibrosis reduction and vasodilation nitric oxide (NO) dependent. Moreover, CGEN 8566S attenuates isoproterenol-induced cardiac remodeling and myocardial infarction injury. Studies using phosphoproteomics have shown that Ang-(1-7) promotes FOXO1 activation and nuclear translocation in human aortic endothelial cells (HAEC). It is not clear, however, whether CGEN 856S is capable to activate the same intracellular pathways than those previously demonstrated for Ang-(1-7). This study evaluated and compared the effect of CGEN 856S and Ang-(1-7) on AKT/eNOS and AKT/FOXO1 activation, using different cell types. Mas-transfected CHO (Chinese Hamster Ovary - CHO-Mas) cells were stimulated with CGEN 856S and Ang-(1-7). Non-transfected CHO cells were used as control. The protein extract was used for, AKT, phospho-AKT, phospho-eNOS, phospho-FOXO1, Mas and GAPDH detection by western blot. CHO-Mas and CHO cells were also exposed to both peptides for NO release measurement, through DAF-FM incorporation technique. HAEC, A549 and DU145 (human tumoral linages from lungs and prostate, respectively) cells were treated with CGEN 856S and Ang-(1-7) with or without previous A779 treatment. The cells were used for immunolocalization of FOXO1, analyzed by confocal microscope and the nuclear fluorescence intensity was quantified. A549 and DU145 cells were also used for cytotoxicity test, being treated with a combination of PI3 kinase inhibitors wortmannin or LY294002 in different concentrations and CGEN856S or Ang-(1-7). The results showed a significant increase phosphorylation of AKT, eNOS as well as the dephosphorylation of FOXO1 only in CHO-Mas cells treated with CGEN856S and Ang-(1-7). CHO-Mas transfect cells treated with CGEN 856S and Ang-(1-7) also promoted a significant release of NO compared with CHO-Mas non-treated cell. No differences were observed in CHO non-transfected cells. HAEC, A549 and DU145 cell types treated with CGEN 856S and Ang-(1-7) showed a significant FOXO1 nuclear translocation. A779 blocked this effect, at least partly. In both A549 and DU145 cells, the combination of the PI3 kinase inhibitors wortmannin and LY294002 with CGEN 856S or Ang-(1-7) showed a potentiated anti-proliferative effect. These data suggest that CGEN 856S and Ang-(1-7) as agonists of Mas receptor had similar effects, and thus represent a potential therapeutic target in cancer and cardiovascular pathologies.
Estudos em biotecnologia baseados em uma plataforma computacional desenvolvida pela empresa Compugen, Tel Aviv Israel permitiram a descoberta de um potencial agonista do receptor Mas, o CGEN 856S, o qual produz vários efeitos semelhantes àqueles produzidos pela Ang-(1-7), incluindo efeitos anti-hipertensivos e cardioprotetores, como diminuição de isquemia, redução de fibrose renal e cardíaca e vasodilatação dependente de óxido nítrico (NO). Além disso, o CGEN 856S é capaz de atenuar o remodelamento cardíaco induzido por isoproterenol e lesão por infarto do miocárdio. Estudos utilizando fosfoproteômica mostraram que a Ang-(1-7) promove ativação e translocação nuclear do fator de transcrição FOXO1 em células de endotélio de aorta humana (HAEC). No entanto, ainda não é claro se o CGEN 856S é capaz de ativar as mesmas vias de sinalização intracelular anteriormente já demonstradas para Ang-(1-7). Este trabalho avaliou e comparou os efeitos do CGEN 856S e da Ang-(1-7) sobre a ativação das vias AKT/eNOS e AKT/FOXO1, utilizando diferentes modelos celulares. Células de ovário de hamster chinês (CHO) transfectadas com o receptor Mas (CHO-Mas) foram estimuladas com CGEN 856S e Ang-(1-7). Células CHO não transfectadas foram usadas como controle. O extrato proteico foi utilizado em Western Blot para detecção das proteínas AKT, AKT fosforilada, eNOS fosforilada, FOXO1 fosforilado, Mas e GAPDH. Células CHO-Mas e CHO foram expostas a ambos os peptídeos para medida da liberação de NO, através da técnica de incorporação de DAF-FM. Células HAEC, A549 e DU145 (as duas últimas, linhagens tumorais de câncer de pulmão humano e próstata humana, respectivamente) foram tratadas com CGEN 856S e Ang-(1-7) com ou sem tratamento prévio com A779, utilizadas para imunolocalização de FOXO1, analisadas por microscopia confocal e a intensidade de fluorescência nuclear foi quantificada. Células A549 e DU145 também foram utilizadas em teste de citotoxicidade, sendo tratadas com uma combinação dos inibidores de PI3K wortmannin ou LY294002 em diferentes concentrações e CGEN 856S ou Ang-(1-7). Os resultados mostraram uma diferença significativa no aumento da fosforilação da AKT, eNOS, bem como na desfosrorilação de FOXO1 apenas em células CHO-Mas tratadas com CGEN 856S e Ang-(1-7). Células CHO-Mas tratadas com ambos os peptídeos também promoveram um aumento significativo na liberação de NO comparado com células CHO-Mas não tratadas. Não foram observadas diferenças em células CHO não transfectadas. Células HAEC, A549 e DU145 tratadas com CGEN 856S e Ang-(1-7) promoveram translocação nuclear significativa de FOXO1. O A779 bloqueou este efeito, pelo menos, parcialmente. Tanto em células A549 quanto em DU145, a combinação dos inibidores de PI3K wortmannin e LY294002 com CGEN 856S e Ang-(1-7) mostrou um efeito anti-proliferativo potencializado. Estes dados sugerem que tanto o CGEN 856S quanto a Ang-(1-7), como agonistas do receptor Mas, possuem efeitos semelhantes e representam um potencial alvo terapêutico no câncer e em patologias cardiovasculares.
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Lechner, Julia. "Urban CGE Modeling: An Introduction." WU Vienna University of Economics and Business, 2011. http://epub.wu.ac.at/3247/1/sre%2Ddisc%2D2011_04.pdf.

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Cities are usually confronted with a large variety of economic development choices. With growing environmental concern as well as rising income and wealth inequalities, assessment of the impacts of such choices is likely to gain in importance. Consequently, the demand for adequate assessment tools will grow. Computable general equilibrium (CGE) models analyze issues of resource allocation and income distribution in market economies. They have become a widely accepted tool for policy assessment over the past two decades but are currently still primarily a field for specialists. This is particularly distinctive in the case of urban CGE models, which are the focus of this paper. (author's abstract)
Series: SRE - Discussion Papers
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Hubic, Amela. "A financial CGE model for Luxembourg." Doctoral thesis, Universite Libre de Bruxelles, 2015. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209083.

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Luxembourg is one of the most successful financial centers in the world. Initially associated with international syndicated loans, euro-bonds and euro-currency markets, Luxembourg has developed as a center for private banking and is currently the second largest center for the domiciliation of investment funds in the world after the US - with a portfolio equivalent to about sixty times the country’s GDP -, and the first captive reinsurance market in the European Union. As in many other financial centers, the interbank market plays an important role. This partly reflects intra-group operations of foreign banks using their Luxembourg branches and subsidiaries to adjust their liquidity position. More generally, Luxembourg has attracted foreign banks seeking to benefit from its favorable regulatory framework, political stability, language skills of the local workforce and the agglomeration of specialized skills in accounting and legal services.

The importance of the financial sector in Luxembourg implies that a computable general equilibrium (CGE) model with explicit modeling of the financial sector is indispensable in order to properly take into account the interaction between the financial and the real sector in the economy and the interconnectedness between different financial institutional sectors (e.g. commercial banks and investment funds). Explicit modeling of the financial sector also allows for an analysis of how the economy might respond to financial shocks.

This dissertation contributes to the literature by developing two analytical tools:

1.\
Doctorat en Sciences économiques et de gestion
info:eu-repo/semantics/nonPublished

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Bohlin, Lars. "Taxation of intermediate goods : a CGE analysis." Doctoral thesis, Örebro universitet, Handelshögskolan vid Örebro universitet, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-11902.

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This dissertation is concerned with tax rates for the use of commodities in general, and energy in particular. Computable General Equilibrium (CGE) models are used to analyze the normative question of whether the tax rate for intermediate use by firms should be the same as the tax rate for final consumption by households. To answer this question, a distinction needs to be made between fiscal taxes for the purpose of raising revenue for the government, and Pigovian taxes for the purpose of changing behaviour. Concerning fiscal taxes, firms should not pay taxes on their use of inputs if the tax rates in final consumption are at their optimal level. If the tax rate for households is above the optimal level, intermediate use in firms should be taxed in order to increase the price of other commodities and reduce the distortion of relative prices. Essay 1 ascertains what factors determine the optimal relation between the tax rate for final consumption by households and intermediate use by firms. Essay 2 analyses Swedish energy taxes from the perspective of reducing global emission of CO2. It is found that the welfare maximizing tax rates are equal for households and firms not participating in emission trading, while firms that participate in emission trading should have a zero tax rate. Essays 3 and 4 deal with methodological issues. Essay 3 derives a new method for estimation of symmetric input-output tables from supply and use tables. This method solves the problem of negative coefficients, makes it possible to use both the industry and commodity technology assumptions simultaneously and enables the commodity technology assumption to be used even when the number of commodities is larger than the number of industries. Essay 4 describes the model used in the first two essays. The price structure developed here makes it possible to take into account price differences between different purchasers other than differences in tax rates. This essay also makes a comparison between the Swedish implementation of this model and other Swedish CGE-models used to analyse climate policy and energy taxation.
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Oñate, Sofía. "Valoración de empresas CGE método de múltiplos." Tesis, Universidad de Chile, 2015. http://repositorio.uchile.cl/handle/2250/134543.

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Tesis para optar al grado de Magíster en Finanzas
Autor, no autoriza el acceso a texto completo de su documento
El siguiente proyecto de título conducente al grado de Magister de Finanzas, tiene por finalidad realizar la valoración económica y financiera de la empresa Compañía General de Electricidad S.A., CGE, a través del método de “valoración por múltiplos”. Inicialmente este trabajo describirá en forma breve las técnicas de este método y el de “flujo de caja descontado”. Posteriormente se realizará un análisis que va de lo general a lo más detallado iniciando con la descripción de la empresa y la industria, para luego estimar la estructura de capital de la empresa, costo patrimonial y el análisis operacional del negocio y la industria. En una segunda etapa y ya con la información base calculada se procederá a proyectar los EERR y flujos de caja libre con el objetivo de realizar la valoración económica de la empresa, determinando así el precio de acción. Posteriormente, se aplicará el método de valoración por múltiplos mediante la utilización de los principales ratios.
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Touzot, Audrey. "Migration et spécification des interneurones GABAergiques corticaux issus de la CGE au cours du développement chez la souris." Thesis, Nice, 2014. http://www.theses.fr/2014NICE4089/document.

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Chez les rongeurs, les interneurones (INs) corticaux sont issus de l’éminence ganglionnaire (EG) médiale (MGE) et caudale (CGE), expriment une combinaison de facteurs définis et migrent tangentiellement puis radialement pour atteindre leur position laminaire définitive. La diversité et la spécification des sous-types d’INs provenant de la MGE ont suscité de nombreuses études, en revanche les mécanismes moléculaires contrôlant la migration et la spécification des INs issus de la CGE demeurent toujours obscurs. Dans cette étude, les voies de migration de ces INs ont été examinées grâce à une lignée de souris rapportrices des interneurones issus de la CGE avant d’analyser le rôle de deux facteurs de transcription, COUP-TFI et COUP-TFII, hautement exprimés dans la CGE. Deux voies de migration non précédemment caractérisées ont alors été identifiées : une voie dorsale (CLMS) où les INs migrent vers l’EG latérale (LGE) et une voie ventrale (CMMS) où les INs migrent vers la MGE. Le CLMS et le CMMS ont donc été analysés, ainsi que la voie de migration caudale (CMS), à différents stades de développement et l’expression spécifique de certains gènes a pu être identifiée. En inactivant conditionnellement COUP-TFI et/ou COUP-TFII dans les INs, les voies de migration sont altérées ainsi que l’expression des marqueurs moléculaires. Comme probable conséquence, les souris mutantes adultes montrent une distribution altérée des sous-populations d’INs en particulier de celles issues de la CGE. Mon étude a donc permis d’identifier et de caractériser deux nouvelles voies de migration pour les INs provenant de la CGE et a montré que COUP-TFs contribuent à leur modulation
In rodents, cortical interneurons (INs) originate from the medial (MGE) and caudal ganglionic eminence (CGE) according to precise temporal schedules, express a defined combination of factors, and reach their final laminar position through tangential and radial cell migration. The diversity and fate-specification of MGE-derived interneuron subtypes are well characterized however the molecular mechanisms controlling the migration and specification of CGE-derived INs are still vague. In this study, I have first investigated the migratory paths of cortical INs using a reporter line specific to the CGE, and then I have assessed the involvement of COUP-TFI and COUP-TFII, which are highly expressed in the embryonic CGE during development, in these paths. My data unravelled two major previously non-characterized migratory streams from the subpallium to the pallium: a dorsal stream (CLMS) in which CGE-derived cells migrate to the lateral GE (LGE), and a ventral one (CMMS) in which CGE-derived cells migrate to the MGE. I have characterized both streams and the already well-described caudal stream (CMS) during different stages of development and identified a series of genes expressed in the migrating cells. By inactivating COUP-TFI and/or COUP-TFII in the developing INs, these streams together with their molecular marker expression are perturbed. As a consequence, adult mutant mice have an altered distribution of interneuron subpopulations, particularly the ones derived from the CGE. Taken together, my study identified and characterized two novel CGE-derived interneuron migratory routes to the cortex and showed that COUP-TFs contribute in modulating these paths
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Vaittinen, Risto. "Trade policies and integration evaluations with CGE-models /." Helsinki : Helsinki School of Economics, 2004. http://helecon3.hkkk.fi/pdf/diss/a235.pdf.

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Azdan, M. Donny. "Water policy reform in Jakarta, Indonesia : a CGE analysis /." The Ohio State University, 2001. http://rave.ohiolink.edu/etdc/view?acc_num=osu1373993667.

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Books on the topic "CGEN"

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Lee, Jaewoo, Jonathan Ostry, Alessandro Prati, Luca Ricci, and Gian-Maria Milesi-Ferretti. Exchange Rate Assessments: CGER Methodologies. Washington, D.C.: International Monetary Fund, 2008. http://dx.doi.org/10.5089/9781589066380.084.

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Miller, Michael. CGE Alcatel: A strategic analysis. New York, NY: Northern Business Information, 1990.

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Bussolo, Maurizio. An interregional CGE model for Italy. [s.l.]: typescript, 1992.

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Su, Min-Jiun. The Taiwanese tariff: A linear CGE approach. Nankang, Taipei: Institute of Economics, Academia Sinica, 1990.

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Huan jing CGE mo xing ji ying yong. Beijing: Ke xue chu ban she, 2011.

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Vaittinen, Risto. Trade policies and integration: Evaluations with CGE -models. [Helsinki]: Helsinki School of Economics, 2004.

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Söderlind, Paul. MAMTAX: A dynamic CGE model for tax reform simulations. Stockholm, Sweden: Konjunkturinstitutet, 1989.

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Broer, D. Peter, and Jukka Lassila, eds. Pension Policies and Public Debt in Dynamic CGE Models. Heidelberg: Physica-Verlag HD, 1997. http://dx.doi.org/10.1007/978-3-662-01660-2.

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Gaudí, Antoni. Antoni Gaudí (1852-1926): Galerie CGER, Bruxelles, 4 octobre-1er décembre 1985. [Barcelona, Spain]: Fundació Caixa de Pensions, 1985.

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Davies, James B. Microsimulation, CGE and macro modelling for transition and developing economies. Helsinki: United Nations University, World Institute for Development Economics Research, 2004.

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Book chapters on the topic "CGEN"

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Robshaw, M. J. B. "Searching for Compact Algorithms: cgen." In Progress in Cryptology - VIETCRYPT 2006, 37–49. Berlin, Heidelberg: Springer Berlin Heidelberg, 2006. http://dx.doi.org/10.1007/11958239_3.

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Borkar, Meenal A., and Nitin. "3D-CGIN: A 3 Disjoint Paths CGIN with Alternate Source." In Advances in Computing and Communications, 25–36. Berlin, Heidelberg: Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-22726-4_4.

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Wlodarczak, G. "51 CGaN Gallium cyanide." In Linear Polyatomic Molecules, 114. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-540-44926-3_53.

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Wlodarczak, G. "52 CGaN Gallium isocyanide." In Linear Polyatomic Molecules, 115–16. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-540-44926-3_54.

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Engelhardt, Heinz, Wolfgang Beck, and Thomas Schmitt. "Kapillar-Gelelektrophorese (CGE)." In Kapillarelektrophorese, 158–76. Berlin, Heidelberg: Springer Berlin Heidelberg, 1994. http://dx.doi.org/10.1007/978-3-642-57901-1_8.

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Engelhardt, Heinz, Wolfgang Beck, and Thomas Schmitt. "Capillary Gel Electrophoresis (CGE)." In Capillary Electrophoresis, 166–85. Berlin, Heidelberg: Springer Berlin Heidelberg, 1996. http://dx.doi.org/10.1007/978-3-642-85854-3_8.

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Larsen, Mette Voldby, Katrine G. Joensen, Ea Zankari, Johanne Ahrenfeldt, Oksana Lukjancenko, Rolf Sommer Kaas, Louise Roer, et al. "The CGE Tool Box." In Applied Genomics of Foodborne Pathogens, 65–90. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-43751-4_5.

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Meng, Samuel, and Mahinda Siriwardana. "Useful CGE Modelling Packages." In Assessing the Economic Impact of Tourism, 25–59. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-40328-1_2.

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Knowlton, Christin A., Michelle Kolton Mackay, Tod W. Speer, Robyn B. Vera, Douglas W. Arthur, David E. Wazer, Rachelle Lanciano, et al. "Cobalt Gray Equivalent (CGE)." In Encyclopedia of Radiation Oncology, 125. Berlin, Heidelberg: Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-540-85516-3_627.

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Hosoe, Nobuhiro, Kenji Gasawa, and Hideo Hashimoto. "The Simple CGE Model." In Textbook of Computable General Equilibrium Modelling, 13–22. London: Palgrave Macmillan UK, 2010. http://dx.doi.org/10.1057/9780230281653_2.

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Conference papers on the topic "CGEN"

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Birmingham, W. P., and D. P. Siewiorek. "Capturing designer expertise the CGEN system." In the 1989 26th ACM/IEEE conference. New York, New York, USA: ACM Press, 1989. http://dx.doi.org/10.1145/74382.74487.

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Saldeen, K., R. Moalli, and T. Saldeen. "EFFECT OF A FIBRIN-DERIVED PEPTIDE ON PULMONARY ANGIOTENSIN CONVERTING ENZYME (ACE) ACTIVITY AND ON PRESSURE RESPONSES TO BRADYKININ (BK)." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644331.

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Decreased ACE activity is a common finding in patients with adult respiratory distress syndrome (ARDS) and in animal models of lung injury. The nature of this effect is unknown. Fibrin, also a common finding in lung injury, is degraded to small peptides by proteolytic enzymes. Peptide 6A, corresponding to amino acid residues 43-47 of the BB-chain of fibrin (cgen), is produced by plasmin degradation of fibrin and has been shown to inhibit ACE in vitro. The purpose of the present investigation was to study whether peptide 6A inhibits pulmonary ACE in vivo and, if so, determine its effect of hemodynamic changes induced by bradykinin (BK) in the rabbit. We investigated the effect of peptide 6A an the hydrolysis of a synthetic ACE substrate, benzoyl-phe-ala-pro (BPAP) in anesthetized rabbits and in isolated lungs. Peptide 6A caused a reversible, dose-dependent inhibition of BPAP hydrolysis. The ID 50 for peptide 6A inhibition of ACE hydrolysis of BPAP was approximately 1 micrcmole.In both isolated rabbit lupgp and in the intact animal, BK injection elicited a dose dependent increase in pulmonary arterial pressure. In intact animals, this was accompanied by a dose dependent decrease in systemic arterial pressure.In both preparations, responses to BK were potentiated by addition of 1 micromole of peptide 6A. In isolated lungs, co-injection of peptide 6A significantly increased the pulmonary artery pressure response to every dose of BK except the highest (1 mg). In the anesthetized rabbit, 1 micromole of peptide 6A significantly (p<0.05) increased the pulmonary hypertensive response to 100 and 200 nanograms of BK and significantly (p<0.05) decreased the systemic hypotensive response following 100 , 200 , 300 and 400 nanograms of BK. The amount of BK needed to increase pulmonary arterial pressure was 1000-fold greater in the isolated lungs than in the intact animals. Peptides of this type might contribute to decreased ACE activity in patients with ARDS and may potentiate BK induced pulmonary hypertension and systemic hypotension in these patients.
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Xu, Wanru, Jian Yu, Zhenjiang Miao, Lili Wan, and Qiang Ji. "Prediction-CGAN." In MM '19: The 27th ACM International Conference on Multimedia. New York, NY, USA: ACM, 2019. http://dx.doi.org/10.1145/3343031.3351073.

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Xiao, Xuerong, Swetava Ganguli, and Vipul Pandey. "VAE-Info-cGAN." In SIGSPATIAL '20: 28th International Conference on Advances in Geographic Information Systems. New York, NY, USA: ACM, 2020. http://dx.doi.org/10.1145/3423457.3429361.

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Kothalawala, I. U., and Thushari Silva. "Colour-based Image Generation using CGAN." In 2018 18th International Conference on Advances in ICT for Emerging Regions (ICTer). IEEE, 2018. http://dx.doi.org/10.1109/icter.2018.8615538.

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Hsieh, Cheng-Pan, Shih-Kai Lee, Ya-Yi Liao, Ren-Jie Huang, and Jung-Hua Wang. "Binarization Using Morphological Decomposition Followed by cGAN." In 2019 IEEE International Conference on Artificial Intelligence and Virtual Reality (AIVR). IEEE, 2019. http://dx.doi.org/10.1109/aivr46125.2019.00044.

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Ma, Hong, Yongjuan Wu, Yan Ma, and Zhenhua Wang. "Optimization scheme of CGN logs." In 2012 IEEE 2nd International Conference on Cloud Computing and Intelligence Systems (CCIS). IEEE, 2012. http://dx.doi.org/10.1109/ccis.2012.6664289.

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Ma, Si, Yinhong Zhang, Jian Min, and Kejun Zhu. "The Design of BESIII CGEM Detector Control System." In 2018 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC). IEEE, 2018. http://dx.doi.org/10.1109/nssmic.2018.8824618.

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Aizawa, Masashi, Ryohei Orihara, Yuichi Sei, Yasuyuki Tahara, and Akihiko Ohsuga. "Hair Shading Style Transfer for Manga with cGAN." In 12th International Conference on Agents and Artificial Intelligence. SCITEPRESS - Science and Technology Publications, 2020. http://dx.doi.org/10.5220/0008961405870594.

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Lin, Chuan-Jie, and Shao-Heng Chen. "NTOU Chinese Grammar Checker for CGED Shared Task." In Proceedings of the 2nd Workshop on Natural Language Processing Techniques for Educational Applications. Stroudsburg, PA, USA: Association for Computational Linguistics, 2015. http://dx.doi.org/10.18653/v1/w15-4403.

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Reports on the topic "CGEN"

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Heinonen, E. W., and R. E. Tapscott. USAF/AAWG/CGET Advanced Agent Reference Database Description. Fort Belvoir, VA: Defense Technical Information Center, January 1996. http://dx.doi.org/10.21236/ada348555.

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Velasco, Andrés M., and Camilo Alberto Cárdenas-Hurtado. A macro CGE model for the colombian economy. Bogotá, Colombia: Banco de la República, January 2015. http://dx.doi.org/10.32468/be.863.

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Cicowiez, Martín, and Agustin Filippo. Macroeconomic Shocks: Simulations in a CGE Model for Haiti. Inter-American Development Bank, January 2019. http://dx.doi.org/10.18235/0001534.

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Cicowiez, Martín, and Agustín Filippo. Human Development: Simulations in a CGE Model for Haiti. Inter-American Development Bank, January 2019. http://dx.doi.org/10.18235/0001535.

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Jiang, S., D. Guo, and B. Carpenter. An Incremental Carrier-Grade NAT (CGN) for IPv6 Transition. RFC Editor, June 2011. http://dx.doi.org/10.17487/rfc6264.

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Iregui-Bohórquez, Ana María. Tax exporting: an analysis using a multiregional CGE model. Bogotá, Colombia: Banco de la República, February 2001. http://dx.doi.org/10.32468/be.171.

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7

Edwards, Brian Keith, Riccardo Boero, and Michael Kelly Rivera. Initial CGE Model Results Summary Exogenous and Endogenous Variables Tests. Office of Scientific and Technical Information (OSTI), August 2017. http://dx.doi.org/10.2172/1374298.

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8

Cianfarani, J. Carrier-Grade NAT (CGN) Deployment with BGP/MPLS IP VPNs. Edited by V. Kuarsingh. RFC Editor, June 2014. http://dx.doi.org/10.17487/rfc7289.

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9

Cicowiez, Martín, and Agustín Filippo. Production and Productive Sectors: Simulations in a CGE Model for Haiti. Inter-American Development Bank, January 2019. http://dx.doi.org/10.18235/0001536.

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10

Cicowiez, Martin, and Agustín Filippo. Government and Institutional Capacity: Simulations in a CGE Model for Haiti. Inter-American Development Bank, January 2019. http://dx.doi.org/10.18235/0001537.

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