Log in

Relevant bibliographies by topics / Challenge formulation / Journal articles

To see the other types of publications on this topic, follow the link: Challenge formulation.

Journal articles on the topic 'Challenge formulation'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 journal articles for your research on the topic 'Challenge formulation.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

Frokjaer, Sven, and Daniel E. Otzen. "Protein drug stability: a formulation challenge." Nature Reviews Drug Discovery 4, no. 4 (2005): 298–306. http://dx.doi.org/10.1038/nrd1695.

Full text

APA, Harvard, Vancouver, ISO, and other styles

2

Carvalho, Luísa. "Entrepreneurship and Regional Development: State of the Art." Technology Transfer and Entrepreneurship 5, no. 2 (2019): 58–66. http://dx.doi.org/10.2174/2213809906666190102111108.

Full text

Abstract:

The presence of subvisible particles (SVPs) in parenteral formulations of biologics is a major challenge in the development of therapeutic protein formulations. Distinction between proteinaceous and non-proteinaceous SVPs is vital in monitoring formulation stability.

APA, Harvard, Vancouver, ISO, and other styles

3

Farrah Payyadhah, B., Siti Salwa, A. G, and Noorul Huda, S. "Artificial Neural Network in the Development of Halal Cosmetic Formulation Containing Okara." global journal al thaqafah SI, no. 1 (2023): 41–52. http://dx.doi.org/10.7187/gjatsi072023-4.

Full text

Abstract:

The development of halal cosmetic formulations presents a challenge to obtain optimised formulations with desirable qualities as it involves many ingredients. The advancement of cosmetic technologies employs multivariate statistical techniques such as artificial neural networks (ANN) to optimise cosmetic formulation, which aims to overcome the shortcomings of traditional formulation methods, which are laborious and cumbersome. Okara is a by-product of the production of soy-based products. Okara has been found to have numerous benefits for many industries and has been discovered as a promising

APA, Harvard, Vancouver, ISO, and other styles

4

Wright, Harry Charles, Duncan Drummond Cameron, and Anthony John Ryan. "Rational Design of a Polyurethane Foam." Polymers 14, no. 23 (2022): 5111. http://dx.doi.org/10.3390/polym14235111.

Full text

Abstract:

Polyurethane (PU) foams are exceptionally versatile due to the nature of PU bond formation and the large variety of polymeric backbones and formulation components such as catalysts and surfactants. This versatility introduces a challenge, namely a near unlimited number of variables for formulating foams. In addition to this, PU foam development requires expert knowledge, not only in polyurethane chemistry but also in the art of evaluating the resulting foams. In this work, we demonstrate that a rational experimental design framework in conjunction with a design of experiments (DoE) approach re

APA, Harvard, Vancouver, ISO, and other styles

5

Lukić, Milica, and Danina Krajišnik. "Challenges and advances in waterless cosmetic product development: Raising awareness of water sustainability." Arhiv za farmaciju 74, no. 6 (2024): 735–57. https://doi.org/10.5937/arhfarm74-52750.

Full text

Abstract:

Water conservation is an essential strategy for managing the world's limited water resources. The life cycle of cosmetic products, which are used in immeasurable quantities in everyday life, involves significant water consumption. Water is a common ingredient in cosmetic products, and it is also used in the manufacturing process. Numerous strategies are being developed to reduce water consumption in the life cycles of different cosmetic products. This paper therefore focuses on efforts to minimize water use in formulation development and challenges which accompany these efforts. Waterless cosm

APA, Harvard, Vancouver, ISO, and other styles

6

Linder, Stephen H., and B. Guy Peters. "Policy formulation and the challenge of conscious design." Evaluation and Program Planning 13, no. 3 (1990): 303–11. http://dx.doi.org/10.1016/0149-7189(90)90061-z.

Full text

APA, Harvard, Vancouver, ISO, and other styles

7

Carroll, J. F., J. P. Benante, M. Kramer, K. H. Lohmeyer, and K. Lawrence. "Formulations of Deet, Picaridin, and IR3535 Applied to Skin Repel Nymphs of the Lone Star Tick (Acari: Ixodidae) for 12 Hours." Journal of Medical Entomology 47, no. 4 (2010): 699–704. http://dx.doi.org/10.1093/jmedent/47.4.699.

Full text

Abstract:

Abstract The efficacies of a 20% 1-methyl-propyl-2-(hydroxyethyl)-1-piperidinecarboxylate (picaridin) spray, 20% 3-(N-acetyl-N-butyl)aminopropionic acid ethyl ester (IR3535) spray, 20% picaridin lotion, 10% IR3535 lotion, and 33% N,N-diethyl-3-methylbenzamide (deet) cream in repelling nymphal lone star ticks, Amblyomma americanum (L.), were determined at 2-h intervals over 12 h using human subjects. A repellent formulation was applied in a 5-cm-wide band encircling a volunteer’s lower leg. For each challenge, 70 host-seeking nymphs were released on each volunteer’s ankle, and tick locations we

APA, Harvard, Vancouver, ISO, and other styles

8

Yoo, Okhee, Britta S. von Ungern-Sternberg, and Lee Yong Lim. "Paediatric Medicinal Formulation Development: Utilising Human Taste Panels and Incorporating Their Data into Machine Learning Training." Pharmaceutics 15, no. 8 (2023): 2112. http://dx.doi.org/10.3390/pharmaceutics15082112.

Full text

Abstract:

This review paper explores the role of human taste panels and artificial neural networks (ANNs) in taste-masking paediatric drug formulations. Given the ethical, practical, and regulatory challenges of employing children, young adults (18–40) can serve as suitable substitutes due to the similarity in their taste sensitivity. Taste panellists need not be experts in sensory evaluation so long as a reference product is used during evaluation; however, they should be screened for bitterness taste detection thresholds. For a more robust evaluation during the developmental phase, considerations of a

APA, Harvard, Vancouver, ISO, and other styles

9

Hill-Batorski, Lindsay, Yasuko Hatta, Michael J. Moser, et al. "Quadrivalent Formulation of Intranasal Influenza Vaccine M2SR (M2-Deficient Single Replication) Protects against Drifted Influenza A and B Virus Challenge." Vaccines 11, no. 4 (2023): 798. http://dx.doi.org/10.3390/vaccines11040798.

Full text

Abstract:

Current influenza vaccines demonstrate low vaccine efficacy, especially when the predominantly circulating strain and vaccine are mismatched. The novel influenza vaccine platform M2- or BM2-deficient single replication (M2SR and BM2SR) has been shown to safely induce strong systemic and mucosal antibody responses and provide protection against significantly drifted influenza strains. In this study, we demonstrate that both monovalent and quadrivalent (Quad) formulations of M2SR are non-pathogenic in mouse and ferret models, eliciting robust neutralizing and non-neutralizing serum antibody resp

APA, Harvard, Vancouver, ISO, and other styles

10

Iermak, Ievgeniia, Ana da Silva, Cristina Kurachi, Vanderlei Bagnato, and Natalia Inada. "Raman Microspectroscopy as a Tool to Elucidate the Efficacy of Topical Formulations Containing Curcumin." Pharmaceuticals 12, no. 1 (2019): 44. http://dx.doi.org/10.3390/ph12010044.

Full text

Abstract:

The success of the onychomycosis treatment is directly associated with factors such as the choice of the medication, the administration route, and the pharmaceutical formulation. Photodynamic therapy (PDT) is an emerging and promising technique indicated for onychomycosis treatment. For this application, the main challenge is the efficient delivery of the photosensitizer (PS). Curcumin is widely used as a PS, however it is an unstable molecule and it is a challenge to develop a formulation with good penetration into the nail plate, maintaining the stability of curcumin. In this study, the mole

APA, Harvard, Vancouver, ISO, and other styles

11

Wallach, Jason, James Gamrat, Rebekah Jauhola-Straight, Jeffrey Becker, and Thomas Eckrich. "Three Birds, One Excipient: Development of an Improved pH, Isotonic, and Buffered Ketamine Formulation for Subcutaneous Injection." Pharmaceutics 14, no. 3 (2022): 556. http://dx.doi.org/10.3390/pharmaceutics14030556.

Full text

Abstract:

Subcutaneous (SC) ketamine has been found to be effective in pain management, though reports of injection site irritation and sterile abscesses exist with currently available ketamine HCl formulations. Such adverse SC reactions are commonly associated with low pH, high osmolality and/or high injection volumes. An optimal SC formulation of ketamine would thus have a pH and osmolality close to physiological levels, without compromising on concentration and, thus, injection volume. Such a formulation should also be buffered to maintain the pH at the acceptable level for extended time periods. As

APA, Harvard, Vancouver, ISO, and other styles

12

Singh, Dilpreet, Manmeet Singh, Abhay Tharmatt, Ashok K. Tiwary, and Neena Bedi. "Polymeric precipitation inhibitor as an effective trigger to convert supersaturated into supersaturable state in vivo." Therapeutic Delivery 10, no. 9 (2019): 599–608. http://dx.doi.org/10.4155/tde-2019-0053.

Full text

Abstract:

The supersaturated state of the drug in vivo is thermodynamically unstable resulting in a delayed response and reduced efficacy. The use of polymeric precipitation inhibitor (PPI) has been demonstrated as an effective trigger for the conversion of supersaturated state to supersaturable state for improving solubilization, thermodynamic maintenance of drug concentration and oral absorption of poorly water-soluble compounds. PPI retards drug precipitation and provides a kinetically stabilized supersaturation state for an extended period in gastric and intestinal fluids. However, the selection of

APA, Harvard, Vancouver, ISO, and other styles

13

Wang, Youqing, Yi Yang, Furong Gao, and Donghua Zhou. "CONTROL OF MULTI-PHASE BATCH PROCESSES: FORMULATION AND CHALLENGE." IFAC Proceedings Volumes 40, no. 5 (2007): 339–44. http://dx.doi.org/10.3182/20070606-3-mx-2915.00104.

Full text

APA, Harvard, Vancouver, ISO, and other styles

14

Tango, Hiroki, Michio Shiotsu, Kohei Yamauchi, and Keiji Imai. "Challenge for Stable Production on Oral Formulation Manufacturing Process." Journal of the Society of Powder Technology, Japan 53, no. 9 (2016): 564–70. http://dx.doi.org/10.4164/sptj.53.564.

Full text

APA, Harvard, Vancouver, ISO, and other styles

15

Bandilla, Dirk, Marcel Goverde, Paolo Giudici, and Olivier Lambert. "Microbial challenge test of a novel epoprostenol sodium formulation." Drug Design, Development and Therapy Volume 11 (August 2017): 2347–57. http://dx.doi.org/10.2147/dddt.s140033.

Full text

APA, Harvard, Vancouver, ISO, and other styles

16

Khan, Dilawar, Daniel Kirby, Simon Bryson, Maryam Shah, and Afzal Rahman Mohammed. "Development of an Age-Appropriate Mini Orally Disintegrating Carvedilol Tablet with Paediatric Biopharmaceutical Considerations." Pharmaceutics 13, no. 6 (2021): 831. http://dx.doi.org/10.3390/pharmaceutics13060831.

Full text

Abstract:

Owing to considerable differences observed in anatomy and physiology between paediatric subsets, it has been well established that children respond to drugs differently compared to adults. Furthermore, from a formulation perspective, there is a distinct challenge to develop a dosage form that is capable of safely, accurately, and reliably delivering the dose across the whole paediatric population. Orally disintegrating mini-tablets (ODMT) have widely been considered as an age-appropriate formulation option that possess the ability for adequate dose flexibility, avoids swallowing difficulties,

APA, Harvard, Vancouver, ISO, and other styles

17

Faroughi, S., and H. Ahmadian. "Shape functions associated with inverse element formulations." Proceedings of the Institution of Mechanical Engineers, Part C: Journal of Mechanical Engineering Science 225, no. 2 (2010): 304–11. http://dx.doi.org/10.1243/09544062jmes2350.

Full text

Abstract:

Super-convergent element formulations in local co-ordinates are obtained using inverse strategies. In the inverse approach discretization errors of the element formulation are minimized leading to super-convergent solutions. In the development of the inverse element model, no shape functions are introduced and therefore the task of element transformation from local to global co-ordinates system remains a challenge. In this paper, a procedure is proposed to produce shape functions associated with the inverse element formulations via hierarchical polynomials. A membrane element formulation is de

APA, Harvard, Vancouver, ISO, and other styles

18

Csányi, Erzsébet, Mónika Bakonyi, Anita Kovács, Mária Budai-Szűcs, Ildikó Csóka, and Szilvia Berkó. "Development of Topical Nanocarriers for Skin Cancer Treatment Using Quality by Design Approach." Current Medicinal Chemistry 26, no. 35 (2019): 6440–58. http://dx.doi.org/10.2174/0929867325666181116143713.

Full text

Abstract:

Background: One of the most compelling medical challenges of this century is the treatment of cancer and among them, skin cancer is the most common type. Thus, current treatments need to be renewed continuously to handle this challenge. Objective: This review presents considerations which can be employed during the development of nanosized formulations dedicated to the topical treatment of skin cancer. We aimed to collect and organize literature data on the treatment options for skin cancer in order to determine the required quality attributes of an effective dermal anticancer formulation. Met

APA, Harvard, Vancouver, ISO, and other styles

19

Lee, Chin Long, and Filip C. Filippou. "Evaluation of Mixed Formulation for Modelling RC Columns with Bond Slip." Applied Mechanics and Materials 553 (May 2014): 470–75. http://dx.doi.org/10.4028/www.scientific.net/amm.553.470.

Full text

Abstract:

Modelling composite members is a challenge for the computer simulation of structural response under extreme loads, because of the energy dissipation due to relative slip between constituent components. Among several finite element formulations proposed in the last years, the recent mixed formulation proposed by the authors could accommodate the slip discontinuity across the element nodes. In this paper this approach is evaluated with the study of the monotonic and cyclic response of a cantilever reinforced concrete column. The first load case showcases the unique capability of the mixed formul

APA, Harvard, Vancouver, ISO, and other styles

20

Kariuki, Stephen Warui, Jackson Wachira, Millien Kawira, and Genson Murithi. "Formaldehyde Use and Alternative Biobased Binders for Particleboard Formulation: A Review." Journal of Chemistry 2019 (October 13, 2019): 1–12. http://dx.doi.org/10.1155/2019/5256897.

Full text

Abstract:

Formaldehyde-based resins are conventionally used as a binder in formulation of particleboard. Epidemiologic studies have shown that formaldehyde is carcinogenic. Efforts to reduce the health hazard effects of the fomaldehyde-based resin in the particleboard formulation have included use of scavengers for formaldehydes and use of an alternative binder. Use of scavengers for the formaldehyde increases the cost and maintenance of particleboard formulation. There is no proof that scavengers eliminate the emission of formaldehyde from particleboard. Use of biobased binders in particleboard formula

APA, Harvard, Vancouver, ISO, and other styles

21

Mansour, Ahd A., Sukalyani Banik, Meenakshi Malik, Alison A. McCormick, and Chandra Shekhar Bakshi. "Development of a Multivalent Subunit Vaccine against Respiratory Tularemia." Journal of Immunology 198, no. 1_Supplement (2017): 147.17. http://dx.doi.org/10.4049/jimmunol.198.supp.147.17.

Full text

Abstract:

Abstract Francisella tularensis (Ft); the causative agent of a fatal human disease tularemia is classified as a Category A Select Agent. No licensed vaccine is available for prevention of tularemia in the U.S.A. In this study, we used a novel Tobacco Mosaic Virus (TMV) based delivery platform for development of a fully protective multi-antigen subunit tularemia vaccine. Previously we have published that a trivalent TMV-conjugate vaccine confers 50% protection in immunized mice against respiratory Ft LVS challenge. In this study, we refined TMV-conjugate vaccine formulation to improve the level

APA, Harvard, Vancouver, ISO, and other styles

22

Kumar, Vipin, Kapil Malviya, and Lavakesh Kumar Omray. "Formulation, characterization and evaluation of Tramadol Hydrochloride Hydrogel." Journal of Drug Delivery and Therapeutics 10, no. 5-s (2020): 177–85. http://dx.doi.org/10.22270/jddt.v10i5-s.4368.

Full text

Abstract:

The challenge in the formulation of novel systems for TDDS is to identify technologies and formulation excipients which simultaneously optimize drug permeation. Our main goal was to design and evaluate a recent alternative for the administration of tramadol HCl. Performed the preformulation study as different evaluation parameters Physiochemical Studies, Solubility Determination, Partition Coefficient, and Preparation of Calibration Curve simultaneously Preparation & Characterization of Hydrogel Formulation Homogeneity, pH Measurement, Drug Content, Viscosity, Spreadability, In-Vitro Perme

APA, Harvard, Vancouver, ISO, and other styles

23

Li, Xuanwen, Fengqiang Wang, Hong Li, Douglas D. Richardson, and David J. Roush. "The measurement and control of high-risk host cell proteins for polysorbate degradation in biologics formulation." Antibody Therapeutics 5, no. 1 (2022): 42–54. http://dx.doi.org/10.1093/abt/tbac002.

Full text

Abstract:

Abstract Nonionic surfactant polysorbates, including PS-80 and PS-20, are commonly used in the formulation of biotherapeutic products for both preventing surface adsorption and acting as stabilizer against protein aggregation. Trace levels of residual host cell proteins (HCPs) with lipase or esterase enzymatic activity have been shown to degrade polysorbates in biologics formulation. The measurement and control of these low abundance, high-risk HCPs for polysorbate degradation are an industry-wide challenge to achieve desired shelf life of biopharmaceuticals in liquid formulation, especially f

APA, Harvard, Vancouver, ISO, and other styles

24

Abbott, Steven. "Practical Formulation Science for Particle-Based Inks." Colloids and Interfaces 3, no. 1 (2019): 23. http://dx.doi.org/10.3390/colloids3010023.

Full text

Abstract:

There is a big gap between idealized colloid science and the needs of a printing ink formulator. This often leads to formulations based on intuition and experience rather than good science. By bringing together the most relevant colloid and interface science with the capabilities of modern apps, it is possible to bridge the gap between theory and reality to the benefit of both the colloid science community and those who need the science to improve their formulations. The process of making current science usable also exposes the limitations of available theories. This suggests a methodology for

APA, Harvard, Vancouver, ISO, and other styles

25

Ahmad, Usama, Zeeshan Ahmad, Ahmed Khan, Juber Akhtar, Satya Singh, and Farhan Ahmad. "Strategies in Development and Delivery of Nanotechnology Based Cosmetic Products." Drug Research 68, no. 10 (2018): 545–52. http://dx.doi.org/10.1055/a-0582-9372.

Full text

Abstract:

AbstractThe science of formulation involving cosmetic ingredients has always been a challenge since the release of active components greatly depends upon the carrier system involved and the selectivity of skin barrier. The principle obstacle of the skin resides in the epidermis and it’s hard for many active components to cross it. The formulation related factors like size of particles, viscosity and lipophilicity of the components also play an important role in permeation of the dermal composition. Though widely used; conventional creams and gels still struggle in terms of success. This work f

APA, Harvard, Vancouver, ISO, and other styles

26

Elzayat, Ehab M., Abdelrahman Y. Sherif, Fahd A. Nasr, et al. "Enhanced Codelivery of Gefitinib and Azacitidine for Treatment of Metastatic-Resistant Lung Cancer Using Biodegradable Lipid Nanoparticles." Materials 16, no. 15 (2023): 5364. http://dx.doi.org/10.3390/ma16155364.

Full text

Abstract:

Lung cancer is a formidable challenge in clinical practice owing to its metastatic nature and resistance to conventional treatments. The codelivery of anticancer agents offers a potential solution to overcome resistance and minimize systemic toxicity. The encapsulation of these agents within nanostructured lipid carriers (NLCs) provides a promising strategy to enhance lymphatic delivery and reduce the risk of relapse. This study aimed to develop an NLC formulation loaded with Gefitinib and Azacitidine (GEF-AZT-NLC) for the treatment of metastatic-resistant lung cancer. The physicochemical prop

APA, Harvard, Vancouver, ISO, and other styles

27

Bullock, Jim. "Challenging the Formulator: Biocontrol and Conventional Crop Protection." Outlooks on Pest Management 31, no. 3 (2020): 132–36. http://dx.doi.org/10.1564/v31_jun_10.

Full text

Abstract:

Whether it is a synthetic or a biological material, the journey of an active ingredient (AI) from manufacture to its target site is a perilous one. Along the way there are numerous opportunities for the AI to be degraded, destroyed or removed. Following production of the AI, it may be vulnerable to chemical and thermal instability. Again, during formulation and on storage after manufacture, possible physical and chemical instability will need to be considered. Compatibility of the AI and co-formulants with packaging materials will also need to be taken into account. During application there ar

APA, Harvard, Vancouver, ISO, and other styles

28

Whitacre, Margaret, Janine Ward, Konner Jackson, et al. "Pre-treatment with a novel synthetic TLR4 agonist prior to challenge with mouse-adapted H1N1 and H2N3 influenza strains reduced morbidity and mortality in BALB/c mice." Journal of Immunology 208, no. 1_Supplement (2022): 64.04. http://dx.doi.org/10.4049/jimmunol.208.supp.64.04.

Full text

Abstract:

Abstract According to the World Health Organization, influenza causes 3–5 million cases of severe illness and 250,000 – 500,000 deaths annually despite the availability of a seasonal vaccine. As an alternative therapy for use in high-risk groups and environments, we evaluated the efficacy of prophylactic treatment with a novel synthetic TLR4 agonist in BALB/c mice. Animals were anesthetized and treated with a TLR4 agonist intranasally (IN) 0 to 28 days prior to a lethal challenge with either H1N1 or H3N2 mouse-adapted human influenza. Animals were monitored daily for weight loss, decreased bod

APA, Harvard, Vancouver, ISO, and other styles

29

Plaunt, Adam J., Sadikul Islam, Tony Macaluso, et al. "Development and Characterization of Treprostinil Palmitil Inhalation Aerosol for the Investigational Treatment of Pulmonary Arterial Hypertension." International Journal of Molecular Sciences 22, no. 2 (2021): 548. http://dx.doi.org/10.3390/ijms22020548.

Full text

Abstract:

Treprostinil palmitil (TP) is a prodrug of treprostinil (TRE), a pulmonary vasodilator that has been previously formulated for inhaled administration via a nebulizer. TP demonstrates a sustained presence in the lungs with reduced systemic exposure and prolonged inhibition of hypoxia-induced pulmonary vasoconstriction in vivo. Here, we report on re-formulation efforts to develop a more convenient solution-based metered-dose inhaler (MDI) formulation of TP, a treprostinil palmitil inhalation aerosol (TPIA) that matches the pharmacokinetic (PK) and efficacy profile of a nebulized TP formulation,

APA, Harvard, Vancouver, ISO, and other styles

30

Plaunt, Adam J., Sadikul Islam, Tony Macaluso, et al. "Development and Characterization of Treprostinil Palmitil Inhalation Aerosol for the Investigational Treatment of Pulmonary Arterial Hypertension." International Journal of Molecular Sciences 22, no. 2 (2021): 548. http://dx.doi.org/10.3390/ijms22020548.

Full text

Abstract:

Treprostinil palmitil (TP) is a prodrug of treprostinil (TRE), a pulmonary vasodilator that has been previously formulated for inhaled administration via a nebulizer. TP demonstrates a sustained presence in the lungs with reduced systemic exposure and prolonged inhibition of hypoxia-induced pulmonary vasoconstriction in vivo. Here, we report on re-formulation efforts to develop a more convenient solution-based metered-dose inhaler (MDI) formulation of TP, a treprostinil palmitil inhalation aerosol (TPIA) that matches the pharmacokinetic (PK) and efficacy profile of a nebulized TP formulation,

APA, Harvard, Vancouver, ISO, and other styles

31

Das, Biswamitra, Tiyasa Das, Rathin Bhowmik, et al. "Development and Evaluation of Preparations Based on Ethanol Extract of Chrysopogon zizanioides, Asteracantha longifolia, Asparagus racemosus, Tinospora cordifolia." Saudi Journal of Biomedical Research 9, no. 07 (2024): 138–48. http://dx.doi.org/10.36348/sjbr.2024.v09i07.001.

Full text

Abstract:

The emergence of antibiotic-resistant bacteria poses a critical challenge to global public health, necessitating the exploration of alternative therapeutic strategies. This study investigates the antimicrobial potential of bioactive compounds derived from four medicinal plants: Chrysopogon zizanioides, Asteracantha longifolia, Asparagus racemosus, and Tinospora cordifolia. These plants, traditionally used in various medicinal systems, contain compounds such as khusimol, stigmasterol, lupeol, shatavarin IV, asparagamine A, tinosporin, and cordifolioside A, which have shown promising antimicrobi

APA, Harvard, Vancouver, ISO, and other styles

32

Reichelt, Katharina, Laura Moody, Julia Wells, and Ian A. James. "Formulating and formulations in dementia care: Reviewing our perspectives." FPOP Bulletin: Psychology of Older People 1, no. 148 (2019): 17–25. http://dx.doi.org/10.53841/bpsfpop.2019.1.148.17.

Full text

Abstract:

Seventy four participants were given the opportunity to comment on a 15 minute presentation on formulation for Behaviours that Challenge (BtC) and to participate in a guided-workshop on the topic. The contents of the responses, feedback and discussions were analysed. It emerged that participants, particularly non-psychologists, were cautious about the use of formulations in the treatment of BtC. Some participants were unclear about the meaning of the term; some felt that formulations were ‘too psychological’; it was also thought that formulations were not always required. These issues are exam

APA, Harvard, Vancouver, ISO, and other styles

33

Patton, D. L., Y. T. Cosgrove Sweeney, T. D. McCarthy, and S. L. Hillier. "Preclinical Safety and Efficacy Assessments of Dendrimer-Based (SPL7013) Microbicide Gel Formulations in a Nonhuman Primate Model." Antimicrobial Agents and Chemotherapy 50, no. 5 (2006): 1696–700. http://dx.doi.org/10.1128/aac.50.5.1696-1700.2006.

Full text

Abstract:

ABSTRACT Three gel formulations (1%, 3%, and 5% [wt/wt]) of SPL7013, a dendrimer known to have antiviral (anti-human immunodeficiency virus and anti-herpes simplex virus) activities, completed a range of preclinical tests in the pigtailed macaque models for vaginally and rectally applied topical microbicide safety assessments. The vaginal safety profile of the 3% SPL7013 gel formulation was equal to that of the 1% formulation but was superior to that of the 5% formulation. The 3% SPL7013 gel was further evaluated for rectal safety and for antichlamydial efficacy with cervical challenge with Ch

APA, Harvard, Vancouver, ISO, and other styles

34

Gonçalves, Gisele Mara Silva, and Adeline Leonello Da Silva. "Oncological cosmetics formulations based on medicinal plants." Revista Eletrônica Acervo Saúde 13, no. 2 (2021): e6195. http://dx.doi.org/10.25248/reas.e6195.2021.

Full text

Abstract:

Objective: Developing dermocosmetic formulations to minimize the harmful and/or undesirable effects of chemotherapy on the skin. Methods: Vegetable compounds with proven hydrating, emollient, anti-inflammatory and antimicrobial action were selected: extracts or tinctures of Arnica montana L., Calendula officinalis L., Punica granatum and Rosmarinus officinalis L. Two formulations were proposed, cream and gel-cream, evaluated for accelerated stability and preservation challenge test, with inoculation of Staphylococcus aureus, Pseudomonas aeruginosa and Escherichia coli, and evaluation for 28 da

APA, Harvard, Vancouver, ISO, and other styles

35

Strazzabosco, Giovanni, Alessia Liboni, Giulia Pezzi, Andrea Alogna, and Daria Bortolotti. "Insights into Liposomal and Gel-Based Formulations for Dermatological Treatments." Gels 11, no. 4 (2025): 245. https://doi.org/10.3390/gels11040245.

Full text

Abstract:

Dermatological diseases pose a significant challenge due to their chronic nature, complex pathophysiology, and the need for effective, patient-friendly treatments. Recent advancements in liposomal and gel-based formulations have played a crucial role in improving drug delivery, therapeutic efficacy, and patient compliance. Liposomal formulations have garnered considerable attention in dermatology due to their ability to encapsulate both hydrophilic and lipophilic compounds, enabling controlled drug release and enhanced skin penetration. However, challenges such as formulation complexity, stabi

APA, Harvard, Vancouver, ISO, and other styles

36

Faers, M. "The Formulation Challenge: Applying Science to Understand and Control Biodelivery and Stability Complexity in Advanced Suspension Formulations." Chemie Ingenieur Technik 86, no. 9 (2014): 1468–69. http://dx.doi.org/10.1002/cite.201450589.

Full text

APA, Harvard, Vancouver, ISO, and other styles

37

Rani, Nisha, Dhruv Dev, and D. N. Prasad. "Recent Trends in developments of Superdisintegrants: An Overview." Journal of Drug Delivery and Therapeutics 12, no. 1 (2022): 163–69. http://dx.doi.org/10.22270/jddt.v12i1.5148.

Full text

Abstract:

Fast dissolving tablets are solid unit dosage forms that dissolve or disintegrate quickly in the mouth without using water. To provide this type of character in a dosage form, different excipients are required. Superdisintegrants are a class of novel agents that have emerged in recent years. Improving drug bioavailability in the pharmaceutical field is a challenge. The inclusion of superdisintegrants in the formulation enhances the formulation's efficacy. The main goal of this review article is to highlight current development in the superdisintegrants. Novel medication delivery techniques hav

APA, Harvard, Vancouver, ISO, and other styles

38

Hoyt, Anne L., Don Bushman, Nathan Lewis, and Robert Faber. "Developing a Modified Preservative Efficacy Testing Approach as a Predictive Tool for the Evaluation of Preservative Systems in Liquid Home Care Products Under Variable Test Conditions." Journal of AOAC INTERNATIONAL 95, no. 1 (2012): 203–5. http://dx.doi.org/10.5740/jaoacint.10-513.

Full text

Abstract:

Abstract How can a formulator have confidence that a preservative system will perform as expected under adverse conditions? Extreme conditions that can lead to the development of “off odors” in the product can be a serious challenge for companies providing home care products in the global market. Formulation and stability testing occur under controlled parameters that simulate limited environmental conditions and microbial challenges are typically performed with a standard inoculum level. While this is an acceptable and dependable process, it does not necessarily assess how well a preservative

APA, Harvard, Vancouver, ISO, and other styles

39

Guembe-Michel, Nerea, Paul Nguewa, and Gustavo González-Gaitano. "Soluplus®-Based Pharmaceutical Formulations: Recent Advances in Drug Delivery and Biomedical Applications." International Journal of Molecular Sciences 26, no. 4 (2025): 1499. https://doi.org/10.3390/ijms26041499.

Full text

Abstract:

Poor water solubility remains a significant challenge in the pharmaceutical industry that limits the therapeutic efficacy and bioavailability of many active pharmaceuticals. Soluplus® (SLP), an amphiphilic graft copolymer made of polyethylene glycol, polyvinyl caprolactam, and polyvinyl acetate, has been gaining interest in recent years as it addresses these limitations by acting as a versatile carrier. Its ability to form stable amorphous dispersions and enhance drug solubility, as well as its physicochemical properties, support its role as a key excipient in advanced drug delivery systems. R

APA, Harvard, Vancouver, ISO, and other styles

40

Rugved, Kashalikar* Gauri Bhivshet Vijay Jagtap. "Review On Ocular in Situ Gels Using Natural Polymers: A Promising Approach for Sustained Ocular Drug Delivery." International Journal of Pharmaceutical Sciences 2, no. 12 (2024): 3498–505. https://doi.org/10.5281/zenodo.14582671.

Full text

Abstract:

Ocular drug delivery remains a significant challenge due to the anatomical and physiological barriers present in the eye. Traditional ocular dosage forms such as eye drops often suffer from issues of poor bioavailability and rapid drug clearance. In recent years, ocular in situ gels, formed by natural polymers, have emerged as a promising strategy for sustained drug delivery to the eye. This review provides an overview of the advantages, formulation strategies, and potential of ocular in situ gels, focusing on natural polymers. These gels are designed to undergo a sol-to-gel transition in resp

APA, Harvard, Vancouver, ISO, and other styles

41

Lorenzo-Veiga, Blanca, Hakon Sigurdsson, and Thorsteinn Loftsson. "Nepafenac-Loaded Cyclodextrin/Polymer Nanoaggregates: A New Approach to Eye Drop Formulation." Materials 12, no. 2 (2019): 229. http://dx.doi.org/10.3390/ma12020229.

Full text

Abstract:

The topical administration route is commonly used for targeting therapeutics to the eye; however, improving the bioavailability of drugs applied directly to the eye remains a challenge. Different strategies have been studied to address this challenge. One of them is the use of aggregates that are formed easily by self-assembly of cyclodextrin (CD)/drug complexes in aqueous solution. The aim of this study was to design a new eye drop formulation based on aggregates formed between CD/drug complexes. For this purpose, the physicochemical properties of the aggregates associated with six CDs and se

APA, Harvard, Vancouver, ISO, and other styles

42

Yosief, Hailemichael O., Majher I. Sarker, Syed Ammar Hussain, and Zerlina Muir. "Effective Removal of Manure/Mud Balls from Cattle Hides using Thioglycolate Salt Containing Formulations." Journal of the American Leather Chemists Association 117, no. 9 (2022): 359–66. http://dx.doi.org/10.34314/jalca.v117i9.6166.

Full text

Abstract:

The effective removal of hardened manure/mud balls from cattle hides remains a challenge for the livestock industry. Hardened manure/mud balls must be removed to minimize the risk of microbial meat contamination and hide quality deterioration. To overcome this challenge, we developed thioglycolic acid and its sodium, potassium and ammonium salts containing formulations. In this study, the developed four formulations were compared based on their efficacy in removing adobe type mud/manure balls from the hides in short time. Hide pieces containing hardened manure/mud balls were soaked in the form

APA, Harvard, Vancouver, ISO, and other styles

43

Anushka, Verma, Nigam Parul, and Rahmath Samah. "Antibacterial Efficacy of a Hydrogel Formulation using Saururus cernuus." PEXACY International Journal of Pharmaceutical Science 6, no. 1 (2023): 81–97. https://doi.org/10.5282/pexacy.8227776.

Full text

Abstract:

Abstract: Antibacterial resistance has become a pressing global health concern, necessitating the exploration of alternative therapeutic agents. This study delved into the potential of <em>Saururus cernuus</em>, a traditionally acknowledged medicinal plant, in a hydrogel formulation, to combat bacterial infections. Four distinct hydrogel formulations were prepared and meticulously evaluated based on various parameters, including pH, viscosity, spreadability, in vitro drug release, and, most crucially, antibacterial activity. The results showcased that all formulations, especially F4, exhibited

APA, Harvard, Vancouver, ISO, and other styles

44

Lee, Wing-Hin, Ching-Yee Loo, Daniela Traini, and Paul M. Young. "Development and Evaluation of Paclitaxel and Curcumin Dry Powder for Inhalation Lung Cancer Treatment." Pharmaceutics 13, no. 1 (2020): 9. http://dx.doi.org/10.3390/pharmaceutics13010009.

Full text

Abstract:

Despite the effort to develop efficient targeted drug delivery for lung cancer treatment, the outcome remains unsatisfactory with a survival rate of 15% after 5 years of diagnosis. Inhalation formulation is an ideal alternative that could ensure the direct deposition of chemotherapeutics to the lungs. However, the design of an inhalable formulation that could simultaneously achieve a high local chemotherapeutic dose to the solid tumor and exert low pulmonary toxicities is a challenge, as the presence of 10–30% of chemotherapeutics in the lung is sufficient to induce toxicity. Therefore, this s

APA, Harvard, Vancouver, ISO, and other styles

45

Angulo-Ibáñez, Adrián, Estibaliz Aranzabe, Garikoitz Beobide, et al. "Slot-Die Process of a Sol–Gel Photocatalytic Porous Coating for Large-Area Fabrication of Functional Architectural Glass." Catalysts 11, no. 6 (2021): 711. http://dx.doi.org/10.3390/catal11060711.

Full text

Abstract:

The slot-die process is an appealing technology for the fabrication of coatings on large-area substrates. However, its application on the production of photocatalytic coatings based on sol–gel formulations remains virtually unexplored. Thus, assessing the suitable formulation of the sol and operational parameters that allow one to yield high-efficacy photocatalyst coatings is a current challenge. This work aims to analyze the transferability of titania sol formulation optimized for dip-coating processes to slot-die technology. In this sense, firstly, the sol formulation is optimized by analyzi

APA, Harvard, Vancouver, ISO, and other styles

46

Singh, Preeti. "Enhanced Medicated Lacquer Formulation for Managing Psoriatic Nail Disease." International Journal of Medical Science And Diagnosis Research 9, no. 1 (2025): 6–18. https://doi.org/10.32553/ijmsdr.v9i1.1050.

Full text

Abstract:

Nail psoriasis often requires prolonged treatment, with frequent relapses being common. Effective management typically involves extended therapy, as oral anti-psoriatic medications can pose a risk of liver toxicity as a notable side effect. Alternative treatments include monthly corticosteroid injections into the nail folds. Topical therapies, such as medicated nail lacquers, offer the advantage of targeted drug delivery directly to the affected area, reducing systemic exposure and minimizing potential adverse effects. However, a significant challenge is achieving effective drug penetration th

APA, Harvard, Vancouver, ISO, and other styles

47

Patel, Pooja, Chinmayi Joshi, Snehal Funde, Hanumanthrao Palep, and Vijay Kothari. "Prophylactic potential of a Panchgavya formulation against certain pathogenic bacteria." F1000Research 7 (October 8, 2018): 1612. http://dx.doi.org/10.12688/f1000research.16485.1.

Full text

Abstract:

A Panchgavya preparation was evaluated for its prophylactic efficacy against bacterial infection, employing the nematode worm Caenorhabditis elegans as a model host. Worms fed with the Panchgavya preparation prior to being challenged with pathogenic bacteria had a better survival rate against four out of five test bacterial pathogens, as compared to the control worms. Panchgavya feeding prior to bacterial challenge was found to be most effective against Staphylococcus aureus, resulting in 27% (p=0.0001) better worm survival. To the best of our awareness, this is the first report demonstrating

APA, Harvard, Vancouver, ISO, and other styles

48

Al-Amin, MD, Federica Bellato, Francesca Mastrotto, et al. "Dexamethasone Loaded Liposomes by Thin-Film Hydration and Microfluidic Procedures: Formulation Challenges." International Journal of Molecular Sciences 21, no. 5 (2020): 1611. http://dx.doi.org/10.3390/ijms21051611.

Full text

Abstract:

Liposomes have been one of the most exploited drug delivery systems in recent decades. However, their large-scale production with low batch-to-batch differences is a challenge for industry, which ultimately delays the clinical translation of new products. We have investigated the effects of formulation parameters on the colloidal and biopharmaceutical properties of liposomes generated with a thin-film hydration approach and microfluidic procedure. Dexamethasone hemisuccinate was remotely loaded into liposomes using a calcium acetate gradient. The liposomes produced by microfluidic techniques s

APA, Harvard, Vancouver, ISO, and other styles

49

Goel, Achhrish, and Dr Himani Goel. "STABILIZATION OF ANTACID FORMULATION WITHOUT SORBITOL." International Journal of Engineering Science and Humanities 3, no. 1 (2013): 29–36. http://dx.doi.org/10.62904/7haetz76.

Full text

Abstract:

The aim of present study was to develop Stabilized Antacid formulation without using sorbitol base. Sedimentation, Redispersibility and caking were the major problem in the stabilization of the antacid formulation. It was very challenging to achieve Antacid formulation without using sorbitol. This challenge achieved by taking nine different (F1-F9) trails batches using Sodium alginate and Xanthan Gum (G). Formulation (F9) obtained from the above trail batches were selected on the basis of three months accelerated stability data.

APA, Harvard, Vancouver, ISO, and other styles

50

Patel, Hinal, Foram Patel, Vinit Jani, et al. "Anti-pathogenic potential of a classical ayurvedic Triphala formulation." F1000Research 8 (October 1, 2020): 1126. http://dx.doi.org/10.12688/f1000research.19787.2.

Full text

Abstract:

A classical ayurvedic polyherbal formulation namely Triphala was assessed for its anti-pathogenic potential against five different pathogenic bacteria. Virulence of four of them towards the model host Caenorhabditis elegans was attenuated (by 18-45%) owing to pre-treatment with Triphala Formulation (TF) (≤20 µg/ml). TF could also exert significant therapeutic effect on worms already infected with Chromobacterium violaceum (MTCC 2656), Serratia marcescens (MTCC 97) or Staphylococcus aureus (MTCC 737). Prophylactic use of TF allowed worms to score 14-41% better survival in face of subsequent pat

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!