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Journal articles on the topic 'Challenges of FBD'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

H, Ouadi. "Applications of Underbalanced Fishbone Drilling for Improved Recovery and Reduced Carbon Footprint in Unconventional Plays." Petroleum & Petrochemical Engineering Journal 7, no. 1 (2023): 1–22. http://dx.doi.org/10.23880/ppej-16000331.

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Fishbone Drilling (FbD) consists of drilling several micro-holes in different directions from the main vertical or deviated wellbore. Similar to multilateral micro-hole drilling, FbD may be used to enhance hydrocarbon production in naturally fractured formations or in refracturing operations by interconnecting the existing natural fractures. When combined with underbalanced drilling using a coiled tubing rig, FbD enhances the production further by easing the natural flow of the hydrocarbon from the reservoir to the wellbore. The design aspects of the Fishbones include determining the number, l

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Ouadi, Habib, Aimen Laalam, Amjed Hassan, Abderraouf Chemmakh, Vamegh Rasouli, and Mohamed Mahmoud. "Design and Performance Analysis of Dry Gas Fishbone Wells for Lower Carbon Footprint." Fuels 4, no. 1 (2023): 92–110. http://dx.doi.org/10.3390/fuels4010007.

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Multilateral well drilling technology has recently assisted the drilling industry in improving borehole contact area and reducing operation time, while maintaining a competitive cost. The most advanced multilateral well drilling method is Fishbone drilling (FbD). This method has been utilized in several hydrocarbon fields worldwide, resulting in high recovery enhancement and reduced carbon emissions from drilling. FbD involves drilling several branches from laterals and can be considered as an alternative method to hydraulic fracturing to increase the stimulated reservoir volume. However, the

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Abdullah, Aleem MD* Maya Charuni Sarihan MD. "Holistic Remedies for Functional Bowel Disorders; Is It Time to Open the Narrative?" International Clinical and Medical Case Reports Journal 3, no. 6 (2024): 1–2. https://doi.org/10.5281/zenodo.11713280.

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In the clinical setting, gastroenterologists are often faced with the challenges of managing functional bowel disorders (FBD). Currently there are limited pharmacological and endoscopic interventions available, leading to a historically unhappy patient population. Patients are often left with unanswered questions and pharmacotherapies that may not address all their symptoms. In this digital age, a platform many patients seek as a resource for advice on health is social media. We looked to this space to get a snapshot of what therapies patients are speaking about when it comes to non-pharmacolo

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Nepomuceno, Fernanda Vinhal, Rita de Cassia Coelho de Almeida Akutsu, Cainara Lins Draeger, and Izabel Cristina Rodrigues da Silva. "Foodborne Diseases: A Study before and during the COVID-19 Pandemic in Brazil." Nutrients 16, no. 1 (2023): 60. http://dx.doi.org/10.3390/nu16010060.

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Foodborne Diseases (FBDs) are a worldwide problem and occur after contaminated food has been ingested, signaling a lack of food quality. Even though the SARS-CoV-2 virus is not transmitted through food, the COVID-19 pandemic has caused several challenges worldwide that have had direct implications on food production and handling, stimulating and reinforcing the adoption of good manufacturing and food handling practices. The aim of this study was to analyze data on notifications of FBD in Brazil in the years before (2018 and 2019) and during (2020 and 2021) the COVID-19 pandemic. Secondary data

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Mulvey, Laura P. A., Mark C. Nikolic, Bethany J. Allen, Tracy A. Heath, and Rachel C. M. Warnock. "From fossils to phylogenies: exploring the integration of paleontological data into Bayesian phylogenetic inference." Paleobiology 51, no. 1 (2025): 214–36. https://doi.org/10.1017/pab.2024.47.

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AbstractIncorporating paleontological data into phylogenetic inference can greatly enrich our understanding of evolutionary relationships by providing insights into the diversity and morphological evolution of a clade over geological timescales. Phylogenetic analysis of fossil data has been significantly aided by the introduction of the fossilized birth–death (FBD) process, a model that accounts for fossil sampling through time. A decade on from the first implementation of the FBD model, we explore its use in more than 170 empirical studies, summarizing insights gained through its application.

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Ndulue, Uchenna Frank, Olusegun Stanley Tomomewo, and Houdaifa Khalifa. "A Comprehensive Review of Fishbone Well Applications in Conventional and Renewable Energy Systems in the Path towards Net Zero." Fuels 4, no. 4 (2023): 376–96. http://dx.doi.org/10.3390/fuels4040024.

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Fishbone drilling (FbD) involves drilling multiple micro-holes branching out in various directions from the primary vertical or deviated wellbore. FbD is similar to multilateral micro-hole drilling and can be employed to boost hydrocarbon production in naturally fractured formations or during refracturing operations by connecting existing natural fractures. Key design elements in fishbones include determining the number, length, and spacing between the branches, and the angle at which the branches deviate from the main borehole. Fishbone wells have emerged as a promising technology for improvi

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Silva, Bianca Lucindo Neves da, and Paula Góes. "LAR, DOCE LAR: LEVANTAMENTO DE DADOS SOBRE O IMPACTO DO AMBIENTE DOMÉSTICO EM FELINOS ACOMETIDOS PELA SÍNDROME DE PANDORA." Revista ft 29, no. 141 (2024): 21–22. https://doi.org/10.69849/revistaft/fa10202412071521.

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Pandora Syndrome in domestic felines is a complex and multifactorial condition that has been gaining increasing attention due to its diagnostic and therapeutic challenges. This Feline Behavioral Disorder (FBD) presents a variety of clinical signs and lower urinary tract disturbances, significantly impacting the quality of life of affected animals. Understanding the genetic and environmental factors involved in the syndrome is essential for the development of effective therapeutic strategies. This study aims to conduct a data survey on the domestic management practices used by cat owners dealin

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Dr., Vishal Yadav Gayatri Pawar* Rutuja Sonawalkar Dr. V. Y. Lokhande. "Challenges and Quality Attributes in Fluidized Bed Processing Method in The Manufacturing of Multiparticulates." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 3182–93. https://doi.org/10.5281/zenodo.15463206.

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Particle coating in fluidized beds is a frequently used technology to preserve active substances or produce well-defined features of the dispersed materials. The bulk of coating procedures is conducted batch-wise, eliminating the possible advantages of the continuous mode of operation, such as lower cost or enhanced management of the process. Particularly when applying many layers of coating, notable advantages may result from ongoing activity. The current study advances    the creation of continuous fluidized beds. covering for chemical and pharmaceutical uses. It is shown that

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Jain, Ishant, and Raghav Upasani. "Innovative Engineering Solutions for Short Neutral Section Maintenance Reduction in Railway Overhead Lines." Advanced Engineering Forum 51 (January 12, 2024): 61–74. http://dx.doi.org/10.4028/p-0kmhu2.

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This work addresses the challenges associated with the development of short neutral sections (SNS) for overhead lines of high-speed moving trains. A crucial function of a short neutral section is to provide electrical isolation between the different phases of AC traction. These sections are typically located in proximity to the traction substation and sectioning posts. The current SNS design presents several issues, including pantograph arcing, wear and tear of the overhead line system, and the need for manual rotation during periodic maintenance. To address these challenges TRIZ is used, a pr

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Ye, Xin, Gencheng Xu, Xueli Cheng, Jin Zhou, and Zhiguang Qin. "Invalid Signatures Searching Bitwise Divisions-Based Algorithm for Vehicular Ad-Hoc Networks." Journal of Advanced Transportation 2021 (May 24, 2021): 1–12. http://dx.doi.org/10.1155/2021/9970851.

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Vehicular ad-hoc networks (VANETs) are the crucial part of intelligent transportation systems (ITS), which are brought to enhance the security, efficiency, and comfort of transportation. VANETs have aroused extensive attention in the world recently. One of the challenges in practice is real time and low delay, which strongly requires VANETs to be efficient. Existing schemes have properly solved the problem which is how to aggregate the signatures and verify the aggregated signature. However, few solutions are proposed to pinpoint all invalid signatures if existing. The algorithms that can find

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Wang, Chengfei. "ELUCIDATING PRODUCT BASED ON SYSTEM-LEVEL DESIGN PHASE: INTELLIGENT FROST PREVENTION EQUIPMENT DESIGN FOR TEA." New Design Ideas 8, no. 2 (2024): 334–47. http://dx.doi.org/10.62476/ndi82334.

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The purpose of this study is to address the challenges of conceptual design creativity and functional derivation for complex products in the System-level Design Phase, filling the research gap in design strategies at the conceptual design stage. Conceptual design of complex products is recognized as a challenging and ill-defined problem involving various interdisciplinary aspects such as technological trends, social factors, functional requirements and aesthetic preferences. Based on a literature review, this study integrates Bytheway's FBD model and Benami & Jin's Creative Stimulation met

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Sharma, S., C. Heisler, J. Jones, and M. J. Stewart. "A77 IMPLEMENTATION OF GUT LINK-IBS; RESULTS OF A SEMI-STRUCTURED INTERVIEW OF PRIMARY CARE PROVIDERS." Journal of the Canadian Association of Gastroenterology 5, Supplement_1 (2022): 89–90. http://dx.doi.org/10.1093/jcag/gwab049.076.

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Abstract Background The Division of Digestive Care and Endoscopy in Halifax, Nova Scotia has had longstanding challenges with GI referral volume outstripping divisional capacity resulting in limited access to specialist care. Many referrals for functional bowel disorders (FBD) are returned to referring providers. Although this helps rationalize limited system resources, it often impairs access to appropriate and necessary GI care. The co-development and implementation of clinical care pathways across gastroenterology and primary care may help to improve access to high-quality GI care. Aims The

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13

Barido-Sottani, Joëlle, Orlando Schwery, Rachel C. M. Warnock, Chi Zhang, and April Marie Wright. "Practical guidelines for Bayesian phylogenetic inference using Markov Chain Monte Carlo (MCMC)." Open Research Europe 3 (June 28, 2024): 204. http://dx.doi.org/10.12688/openreseurope.16679.2.

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Phylogenetic estimation is, and has always been, a complex endeavor. Estimating a phylogenetic tree involves evaluating many possible solutions and possible evolutionary histories that could explain a set of observed data, typically by using a model of evolution. Modern statistical methods involve not just the estimation of a tree, but also solutions to more complex models involving fossil record information and other data sources. Markov Chain Monte Carlo (MCMC) is a leading method for approximating the posterior distribution of parameters in a mathematical model. It is deployed in all Bayesi

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Barido-Sottani, Joëlle, Orlando Schwery, Rachel C. M. Warnock, Chi Zhang, and April Marie Wright. "Practical guidelines for Bayesian phylogenetic inference using Markov chain Monte Carlo (MCMC)." Open Research Europe 3 (August 5, 2024): 204. http://dx.doi.org/10.12688/openreseurope.16679.3.

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Phylogenetic estimation is, and has always been, a complex endeavor. Estimating a phylogenetic tree involves evaluating many possible solutions and possible evolutionary histories that could explain a set of observed data, typically by using a model of evolution. Values for all model parameters need to be evaluated as well. Modern statistical methods involve not just the estimation of a tree, but also solutions to more complex models involving fossil record information and other data sources. Markov chain Monte Carlo (MCMC) is a leading method for approximating the posterior distribution of pa

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Barido-Sottani, Joëlle, Orlando Schwery, Rachel C. M. Warnock, Chi Zhang, and April Marie Wright. "Practical guidelines for Bayesian phylogenetic inference using Markov Chain Monte Carlo (MCMC)." Open Research Europe 3 (November 20, 2023): 204. http://dx.doi.org/10.12688/openreseurope.16679.1.

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Phylogenetic estimation is, and has always been, a complex endeavor. Estimating a phylogenetic tree involves evaluating many possible solutions and possible evolutionary histories that could explain a set of observed data, typically by using a model of evolution. Modern statistical methods involve not just the estimation of a tree, but also solutions to more complex models involving fossil record information and other data sources. Markov Chain Monte Carlo (MCMC) is a leading method for approximating the posterior distribution of parameters in a mathematical model. It is deployed in all Bayesi

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16

Cai, Yanxuan (Tina), Michael McLaughlin, and Kai Zhang. "Advancing the FDA/Office of Regulatory Affairs Mycotoxin Program: New Analytical Method Approaches to Addressing Needs and Challenges." Journal of AOAC INTERNATIONAL 103, no. 3 (2020): 705–9. http://dx.doi.org/10.1093/jaocint/qsz007.

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Abstract The U.S. Food and Drug Administration (FDA), Office of Regulatory Affairs (ORA) oversees FDA field laboratories, monitoring the occurrence and levels of toxic mycotoxins in domestic and imported human and animal food products that have the potential to impact human and animal health when consumed. The mycotoxins being routinely monitored in human and animal foods and feeds by the Agency include aflatoxins (B1, B2, G1, G2, and M1), fumonisins (FB1, FB2, and FB3), deoxynivalenol, ochratoxin A, patulin, and zearalenone. There has been an ongoing expansion of the Sample Collection Operati

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Yan, Zhengjun, Xing Zheng, Wei Li, et al. "FireDA: A Domain Adaptation-Based Method for Forest Fire Recognition with Limited Labeled Scenarios." Forests 15, no. 10 (2024): 1684. http://dx.doi.org/10.3390/f15101684.

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Vision-based forest fire detection systems have significantly advanced through Deep Learning (DL) applications. However, DL-based models typically require large-scale labeled datasets for effective training, where the quality of data annotation is crucial to their performance. To address challenges related to the quality and quantity of labeling, a domain adaptation-based approach called FireDA is proposed for forest fire recognition in scenarios with limited labels. Domain adaptation, a subfield of transfer learning, facilitates the transfer of knowledge from a labeled source domain to an unl

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18

Li, Jinhua, Dongxu Jia, Zhenyuan Zhou, Jincheng Du, Qiangang Xiao, and Mingrong Cao. "Stability Analysis and Multi-Trait Selection of Flowering Phenology Parameters in Olive Cultivars Under Multi-Environment Trials." Plants 14, no. 13 (2025): 1906. https://doi.org/10.3390/plants14131906.

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Flowering represents the most important process in the reproductive stage of fruit trees, including olive trees. Previous studies have demonstrated that the genotype–environment interaction (GEI) has a considerable influence on olive flowering time. This study investigated the GEI and genetic parameters influencing olive flowering phenology in Southwestern China (a non-Mediterranean region), using multi-trait-based stability selection methods. Sixteen olive cultivars from five countries were evaluated over two years in two distinct climatic regions of Southwestern China. Flowering phenology wa

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19

Claudino-Silva, S. C., B. Lala, N. H. A. P. Mora, et al. "Challenge with fumonisins B1 and B2 changes IGF-1 and GHR mRNA expression in liver of Nile tilapia fingerlings." World Mycotoxin Journal 11, no. 2 (2018): 237–45. http://dx.doi.org/10.3920/wmj2017.2208.

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Although fumonisins are identified as responsible for alterations in weight gain, little information is available on their effects on expression of growth-related genes, especially for Nile tilapia (Oreochromis niloticus) fingerlings. In this study, Nile tilapia fingerlings were treated with increasing levels of fumonisin B1 (FB1) and fumonisin B2 (FB2) (diets of 0, 20, 40, and 60 mg/kg) to evaluate their effects on weight gain (WG), feed intake (FI), feed efficiency (FE), growth hormone receptor (GHR) and insulin growth factor 1 (IGF-1) mRNA expression in liver of this fish. All variables wer

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Lala, Bruno, Carolina Toledo Santos, Gabriel Roldi, et al. "Challenge with fumonisin FB1 + FB2 alters profile of fatty acids in Nile tilapia fingerlings." Aquaculture 516 (February 2020): 734546. http://dx.doi.org/10.1016/j.aquaculture.2019.734546.

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Enck, Paul, and Nazar Mazurak. "Dysbiosis in Functional Bowel Disorders." Annals of Nutrition and Metabolism 72, no. 4 (2018): 296–306. http://dx.doi.org/10.1159/000488773.

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Functional bowel disorders (FBD) resemble a group of diseases of the gastrointestinal (GI) tract that are without a clear pathogenesis; the best known is probably the “irritable bowel syndrome” (IBS). Only recently we have been able to explore the role of the gut microbiota in FBD due to progress in microbiological analytic techniques. There are different ways to explore the role of the gut microbiota and its dysbiosis in FBD. Comparison of the microbial composition in a group of patients with FBD, for example, with IBS to a group of healthy volunteers is one way. Studies have shown that the m

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Khawandanah, Jomana, and Ihab Tewfik. "Fad Diets: Lifestyle Promises and Health Challenges." Journal of Food Research 5, no. 6 (2016): 80. http://dx.doi.org/10.5539/jfr.v5n6p80.

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Chronic excess of dietary intake combined with reduced energy expenditure increase the positive energy balance. This transition in behaviour contributes significantly to prevalence of obesity, impairment of health, reduction in quality of life and increases health-care costs. While obesity has turned into a public health threat, with the government failing to reverse this growing trend, good number of people is undertaking fad diets with the hope to lose weight fast and easy. Furthermore, media and peers contribute to the popularity of fad diets as they put pressure to individuals who desire a

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23

Gresham, Frank M. "Establishing the Technical Adequacy of Functional Behavioral Assessment: Conceptual and Measurement Challenges." Behavioral Disorders 28, no. 3 (2003): 282–98. http://dx.doi.org/10.1177/019874290302800305.

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Functional behavioral assessment (FBA) is being used increasingly in schools as a potentially effective means of matching intervention strategies to behavioral function. The unqualified use of FBA often is driven more by legal and policy decisions than by sound empirical data dictating its efficacy in all cases. Two fundamental questions have not been adequately answered by the FBA literature: (a) Are interventions matched to the operant function of behavior more effective than interventions not matched to the function of behavior? and (b) Can researchers and practitioners determine behavioral

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Togre, Namdev S., Ana M. Vargas, Gunapati Bhargavi, Mohan Krishna Mallakuntla, and Sangeeta Tiwari. "Fragment-Based Drug Discovery against Mycobacteria: The Success and Challenges." International Journal of Molecular Sciences 23, no. 18 (2022): 10669. http://dx.doi.org/10.3390/ijms231810669.

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The emergence of drug-resistant mycobacteria, including Mycobacterium tuberculosis (Mtb) and non-tuberculous mycobacteria (NTM), poses an increasing global threat that urgently demands the development of new potent anti-mycobacterial drugs. One of the approaches toward the identification of new drugs is fragment-based drug discovery (FBDD), which is the most ingenious among other drug discovery models, such as structure-based drug design (SBDD) and high-throughput screening. Specialized techniques, such as X-ray crystallography, nuclear magnetic resonance spectroscopy, and many others, are par

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Galanaki, Eleanna, Emma Parry, Ilona Bučiūnienė, and Leda Panayotopoulou. "Demographic challenges for management: fad or reality?" Evidence-based HRM: a Global Forum for Empirical Scholarship 7, no. 1 (2019): 2–7. http://dx.doi.org/10.1108/ebhrm-04-2019-065.

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Lidgate, D. "FBC Technology and the Environmental Challenge." Engineering Science and Education Journal 1, no. 4 (1992): 156. http://dx.doi.org/10.1049/esej:19920033.

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Lanni, Luigi, Valeria Morena, Adriana Scattareggia Marchese, et al. "Challenge Test as Special Tool to Estimate the Dynamic of Listeria monocytogenes and Other Foodborne Pathogens." Foods 11, no. 1 (2021): 32. http://dx.doi.org/10.3390/foods11010032.

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Over 23 million cases of foodborne disease (FBD) occur in Europe each year, with over 4700 deaths. Outbreaks of FBD have a significant impact on our society due to the high economic losses they cause (hospital treatment of affected patients and destruction of contaminated food). Among its health objectives, the European Union has set itself the goal of reducing the incidence of the main FBDs, approving various regulations that codify requirements in order to produce food that is “safe” for human consumption. Among these rules, Regulation 2005/2073 establishes precise food safety criteria for f

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Gottstein, Willi, Brett G. Olivier, Frank J. Bruggeman, and Bas Teusink. "Constraint-based stoichiometric modelling from single organisms to microbial communities." Journal of The Royal Society Interface 13, no. 124 (2016): 20160627. http://dx.doi.org/10.1098/rsif.2016.0627.

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Microbial communities are ubiquitously found in Nature and have direct implications for the environment, human health and biotechnology. The species composition and overall function of microbial communities are largely shaped by metabolic interactions such as competition for resources and cross-feeding. Although considerable scientific progress has been made towards mapping and modelling species-level metabolism, elucidating the metabolic exchanges between microorganisms and steering the community dynamics remain an enormous scientific challenge. In view of the complexity, computational models

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Bonadies, Anna, Felice Corvino, Margherita Rosa, et al. "Alcune malattie trasmesse da alimenti da non dimenticare." Medico e Bambino 40, no. 3 (2021): 167–72. http://dx.doi.org/10.53126/meb40167.

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Foodborne diseases (FBDs) are still a major public health problem. They are often caused by toxic sub-stances due to incorrect food storage. The paper describes three cases of FBD recently observed: the first concerns the so-called scombroid syndrome, the second Infant Botulism and the third acquired methemoglo-binemia. FBDs are now relatively rare so their recognition often represents a diagnostic challenge for pae-diatricians

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Walters, K., and M. F. Webster. "The distinctive CFD challenges of computational rheology." International Journal for Numerical Methods in Fluids 43, no. 5 (2003): 577–96. http://dx.doi.org/10.1002/fld.522.

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Lu, Hang, Nathan Horn, and Kola Ajuwon. "56 Effects of mycotoxins and selected feed additives on viability and tight junction integrity of IPEC-J2 cells." Journal of Animal Science 98, Supplement_4 (2020): 37. http://dx.doi.org/10.1093/jas/skaa278.066.

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Abstract Mycotoxins are deleterious feed contaminants routinely found in cereal gains used in livestock feed. Development of strategies to eliminate mycotoxins and mitigate their harmful effects on the animal is of major importance to the livestock industry. The objective of the current study was to determine the effects of deoxynivalenol (DON), aflatoxin B1 (AFB1) and fumonisin B1(FB1), and selected prebiotic, probiotic, and essential oil blended feed additives, on viability and integrity in porcine intestinal epithelial cell line (IPEC-J2). IPEC-J2 cells were treated with each individual myc

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van Lieshout, Machteld, Wendy Scholtes-Bos, Judith M. van der Horst-Graat, Puck van Holsteijn, and Sanne I. de Vries. "Development of the Food Boost Challenge: A Participatory Action Research Approach to Enhance Vegetable and Fruit Consumption among Adolescents." Nutrients 15, no. 23 (2023): 4921. http://dx.doi.org/10.3390/nu15234921.

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Prevention of non-communicable diseases through, among other factors, increasing vegetables and fruit (V&F) intake is a cost-effective strategy for risk reduction but requires behavioral change. Such changes in adolescents benefit from their active involvement. The Food Boost Challenge (FBC) was developed using a participatory action research approach to enhance healthy eating behaviors, namely V&F products among adolescents. The FBC is an innovation process, involving adolescents, (peer) researchers, and food system partners, like non-governmental and commercial organizations. In 2021

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Coyle, Joe, and Reto Walser. "Applied Biophysical Methods in Fragment-Based Drug Discovery." SLAS DISCOVERY: Advancing the Science of Drug Discovery 25, no. 5 (2020): 471–90. http://dx.doi.org/10.1177/2472555220916168.

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Fragment-based drug discovery (FBDD) has come of age in the last decade with the FDA approval of four fragment-derived drugs. Biophysical methods are at the heart of hit discovery and validation in FBDD campaigns. The three most commonly used methods, thermal shift, surface plasmon resonance, and nuclear magnetic resonance, can be daunting for the novice user. We aim here to provide the nonexpert user of these methods with a summary of problems and challenges that might be faced, but also highlight the potential gains that each method can contribute to an FBDD project. While our view on FBDD i

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Tobin, Margaret. "Money, Management and Outcomes: The New Challenge." Australasian Psychiatry 5, no. 5 (1997): 223–24. http://dx.doi.org/10.3109/10398569709082275.

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The proposition will be made in this paper, that the outcomes focus in mental health is not merely a passing political fad, destined to go the way of trends in terminology changes in health such as patients, customers, consumers etc. It is a challenge to service hinders and providers to make a difference to the health of the population being served. Its foundations lie in three main themes.

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Chapman, Annelise S., Pierrick Stévant, and Wenche Emblem Larssen. "Food or fad? Challenges and opportunities for including seaweeds in a Nordic diet." Botanica Marina 58, no. 6 (2015): 423–33. https://doi.org/10.1515/bot-2015-0044.

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Chapman, Annelise S., Stévant, Pierrick, Larssen, Wenche Emblem (2015): Food or fad? Challenges and opportunities for including seaweeds in a Nordic diet. Botanica Marina (Warsaw, Poland) 58 (6): 423-433, DOI: 10.1515/bot-2015-0044, URL: https://doi.org/10.1515/bot-2015-0044

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Yeung, Alex, Nagabhushana Rao Vadlamani, Tom Hynes, and Sumit Sarvankar. "Quasi 3D Nacelle Design to Simulate Crosswind Flows: Merits and Challenges." International Journal of Turbomachinery, Propulsion and Power 4, no. 3 (2019): 25. http://dx.doi.org/10.3390/ijtpp4030025.

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This paper studies the computational modelling of the flow separation over the engine nacelle lips under the off-design condition of significant crosswind. A numerical framework is set up to reproduce the general flow characteristics under crosswinds with increasing engine mass flow rate, which include: low-speed separation, attached flow and high speed shock-induced separation. A quasi-3D (Q3D) duct extraction method from the full 3D (F3D) simulations has been developed. Results obtained from the Q3D simulations are shown to largely reproduce the trends observed (isentropic Mach number variat

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Krymska, Anna, Andrii Chalii, Victoria Petruk, Olena Kobzieva, and Olena Tytar. "Challenges and opportunities of digital transformation in Ukrainian education." Futurity Education 4, no. 3 (2024): 182–99. http://dx.doi.org/10.57125/fed.2024.09.25.11.

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An important and necessary trend in the modern Ukrainian education system is the digitalisation of the educational process due to the forced transition of many educational institutions to distance learning due to the coronavirus pandemic and the Russian-Ukrainian war. The purpose of the article is to theoretically substantiate the challenges and opportunities for the introduction of digital learning technologies in Ukrainian educational institutions. The following methods were used to write the article and to reveal its purpose: conceptual and terminological analysis, comparative and contrasti

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Kostenko, Liudmyla, Oksana Ruda, Maryna Sofilkanych, and Anna Bokshan. "Distance learning as an integrative response to contemporary challenges." Futurity Education 3, no. 1 (2023): 151–64. http://dx.doi.org/10.57125/fed/2022.10.11.12.

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The COVID-19 pandemic has raised the issue of using distance learning as a separate independent model of organizing the educational process. The purpose of the article is to analyze distance learning as a form of organizing the educational process, which is dynamically developing in response to global challenges, from the point of view of an integral approach. Accordingly, the object of the study is modern forms of distance learning as a way of organizing the educational process. To achieve this goal, an analytical research approach was used that allows correlating and identifying effective so

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Scholtes-Bos, Wendy, Machteld van Lieshout, Michelle H. I. van Roost, and Sanne I. de Vries. "Beyond Healthy Eating: The Broader Impact of the Food Boost Challenge’s Participatory Approach with Young People." Social Sciences 14, no. 4 (2025): 246. https://doi.org/10.3390/socsci14040246.

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The Food Boost Challenge (FBC) uses a community-up participatory action research approach to promote healthier eating habits among young people, aged 10–24 years old, by giving them a voice in food system change. This approach encourages turning ideas into action through collaboration with young people, both adolescents and students, teachers, researchers, and food system partners. This study explored the impact of the FBC beyond its direct effect on healthy eating behavior, focusing on innovative idea generation and how participation affected young people and partners, at both the individual

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Li, Charles, Hyun Lillehoj, Xianghe Yan, et al. "Immunization with a subunit of housekeeping proteins provide partial protection against experimental necrotic enteritis in broiler chickens." Journal of Immunology 204, no. 1_Supplement (2020): 168.25. http://dx.doi.org/10.4049/jimmunol.204.supp.168.25.

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Abstract Necrotic enteritis (NE) due to Clostridium perfringens (CP) infections is a prevalent enteric infectious disease accounting for $6 billion economical loss in global poultry industry. The increasing incidence of NE has been associated with the reduction and withdrawal of antibiotic growth promoters from animal feed during recent years. Therefore, the development of effective vaccines specific for NE assumes a priority for poultry industry. By far, no any effective vaccines are commercially available in broiler chickens. Our aim was to identify the potential CP proteins as vaccine targe

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Sarper Erikci, Volkan. "Airway Foreign Bodies in Children: A Review Article." Journal of Clinical Research and Reports 11, no. 3 (2022): 01–04. http://dx.doi.org/10.31579/2690-1919/250.

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Foreign body aspiration (FBA) in children represents a significant morbidity and even mortality producing sudden deaths. Regarded as a major public health issue, FBA may be the end result of aspiration of various organic and inorganic materials. Parental and public awareness including preventive measures is important in avoiding these injuries. The consequences of FBA may pose great challenge for both the children, their families together with clinicians dealing with these children. In this review article it is aimed to discuss the epidemiology, clinical presentations, diagnosis and treatment

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Chen, Jianlin, Junjie Peng, Changjun Ma, et al. "Co-Expression of Pig IL-2 and Fusion Bovine Cathelicidin Gene by Recombinant Plasmids in Yeast and Their Promotion of Mouse Antibacterial Defense." Biology 11, no. 10 (2022): 1491. http://dx.doi.org/10.3390/biology11101491.

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In order to develop an effective and safe immunomodulator to enhance the antimicrobial bioactivity and immunity of animals against infectious bacterial diseases, a recombinant plasmid pGAPZαA-IL2-B co-expressing pig interleukin-2 (PIL-2) and fused bovine cathelicidin (FBC) genes were constructed using the 2A self-cleavage technique. After being expressed in Pichia pastoris strain SMD1168, the recombinant yeast was administered orally to 5-week-old female ICR mice. The control mice were similarly dosed with P. pastoris with a blank plasmid or FBC recombinant plasmid alone. At 28 days post-treat

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Kruger, Nicholas J., and R. George Ratcliffe. "Fluxes through plant metabolic networks: measurements, predictions, insights and challenges." Biochemical Journal 465, no. 1 (2014): 27–38. http://dx.doi.org/10.1042/bj20140984.

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Although the flows of material through metabolic networks are central to cell function, they are not easy to measure other than at the level of inputs and outputs. This is particularly true in plant cells, where the network spans multiple subcellular compartments and where the network may function either heterotrophically or photoautotrophically. For many years, kinetic modelling of pathways provided the only method for describing the operation of fragments of the network. However, more recently, it has become possible to map the fluxes in central carbon metabolism using the stable isotope lab

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Joseph, Nisheed, and Gayathri Subhash Banasode. "Anaesthetic management of a rare case of congenital factor VII deficiency – Patient posted for shoulder arthroscopic synovectomy: A case report." Practical Evidence in Anaesthesia Knowledge 1 (February 15, 2025): 44–47. https://doi.org/10.25259/peak_10_2024.

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Factor VII deficiency (F7D) is a rare coagulation disorder. It poses significant challenges for anaesthetic management due to a heightened risk of bleeding. This case report describes the successful anaesthetic management of a 20-year-old woman with congenital F7D who underwent elective shoulder arthroplasty for ‘Pigmented Villonodular Synovitis.’ A multidisciplinary approach incorporating preoperative recombinant activated factor VII and tranexamic acid, general anaesthesia with an interscalene brachial block, and meticulous surgical technique and close monitoring ensured a favourable outcome

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Nakahashi, Kazuhiro, Yasushi Ito, and Fumiya Togashi. "Some challenges of realistic flow simulations by unstructured grid CFD." International Journal for Numerical Methods in Fluids 43, no. 6-7 (2003): 769–83. http://dx.doi.org/10.1002/fld.559.

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Vizzard, William. "Transforming the FBI: A Challenge of Culture, Resources, and Mission." Public Administration Review 66, no. 5 (2006): 764–66. http://dx.doi.org/10.1111/j.1540-6210.2006.00641.x.

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Holbrook, Morris B. "Complexity and Management: Fad or Radical Challenge to Systems Thinking?" Journal of Macromarketing 22, no. 2 (2002): 198–201. http://dx.doi.org/10.1177/0276146702238228.

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Hailu, Yohannes, and Sisay Yifru. "Assessment of knowledge, attitude, and practice towards the first aid management of foreign body aspiration and obstruction among parents of children visited SPHMMC, Addis Ababa, Ethiopia." International Journal of Scientific Reports 11, no. 4 (2025): 154–62. https://doi.org/10.18203/issn.2454-2156.intjscirep20250747.

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Background: Foreign body aspiration (FBA) is a leading cause of accidental death in childhood. FBs in the aerodigestive tract pose diagnostic and therapeutic challenges, contributing significantly to morbidity and mortality. Limited community awareness regarding FBA presentation and management exacerbates the problem. Few studies exist in this area, highlighting the need for further research to improve parental awareness of immediate first aid interventions and prevent delays in healthcare access. Methods: A descriptive cross-sectional study was conducted at St. Paul’s hospital millennium medi

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Yang, Yuyao, Shuangjia Zheng, Shimin Su, Chao Zhao, Jun Xu, and Hongming Chen. "SyntaLinker: automatic fragment linking with deep conditional transformer neural networks." Chemical Science 11, no. 31 (2020): 8312–22. http://dx.doi.org/10.1039/d0sc03126g.

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Osborne, James, Stanislava Panova, Magdalini Rapti, Tatsuya Urushima, and Harren Jhoti. "Fragments: where are we now?" Biochemical Society Transactions 48, no. 1 (2020): 271–80. http://dx.doi.org/10.1042/bst20190694.

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Fragment-based drug discovery (FBDD) has become a mainstream technology for the identification of chemical hit matter in drug discovery programs. To date, the food and drug administration has approved four drugs, and over forty compounds are in clinical studies that can trace their origins to a fragment-based screen. The challenges associated with implementing an FBDD approach are many and diverse, ranging from the library design to developing methods for identifying weak affinity compounds. In this article, we give an overview of current progress in fragment library design, fragment to lead o

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