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Journal articles on the topic 'Characteristics osteoblasts'

Author: Grafiati

Published: 28 May 2022

Last updated: 30 July 2025

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1

Wang, Liping, Hung-Yao Hsu, Xu Li, and Cory J. Xian. "Effects of Frequency and Acceleration Amplitude on Osteoblast Mechanical Vibration Responses: A Finite Element Study." BioMed Research International 2016 (2016): 1–16. http://dx.doi.org/10.1155/2016/2735091.

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Bone cells are deformed according to mechanical stimulation they receive and their mechanical characteristics. However, how osteoblasts are affected by mechanical vibration frequency and acceleration amplitude remains unclear. By developing 3D osteoblast finite element (FE) models, this study investigated the effect of cell shapes on vibration characteristics and effect of acceleration (vibration intensity) on vibrational responses of cultured osteoblasts. Firstly, the developed FE models predicted natural frequencies of osteoblasts within 6.85–48.69 Hz. Then, three different levels of acceler

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Chen, Wen-ming, Zi-xing Chen, Jian-nong Cen, et al. "The Biological Characteristics of Osteoblasts Derived from Myelodysplastic Syndrome Patients." Blood 110, no. 11 (2007): 4101. http://dx.doi.org/10.1182/blood.v110.11.4101.4101.

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Abstract It was hypothesized that osteoblasts play a central role in hematopoiesis, and it has been shown that osteoblasts produce many factors essential for the survival, renewal, and maturation of hematopoietic stem cells (HSCs). By using human fetal osteoblastic cell line hFOB1.19 as a model of control, we investigated the biological characteristics of osteoblasts derived from patients with myelodysplastic syndrome (MDS) and their hematopoietic supportive function in vitro. MSCs isolated from bone marrow of MDS patients and normal donors were cultured and checked for their morphology, immun

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Cha, Hyeonjin, Jaeyoung Lee, Hee Ho Park, and Ju Hyun Park. "Direct Conversion of Human Fibroblasts into Osteoblasts Triggered by Histone Deacetylase Inhibitor Valproic Acid." Applied Sciences 10, no. 20 (2020): 7372. http://dx.doi.org/10.3390/app10207372.

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The generation of functional osteoblasts from human somatic cells could provide an alternative means of regenerative therapy for bone disorders such as osteoporosis. In this study, we demonstrated the direct phenotypic conversion of human dermal fibroblasts (HDFs) into osteoblasts by culturing them in osteogenic medium supplemented with valproic acid (VPA), a histone deacetylase (HDAC) inhibitor. HDFs cultured with the VPA in osteogenic medium exhibited expression of alkaline phosphatase and deposition of mineralized calcium matrices, which are phenotypical characteristics of functional osteob

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Liao, Li, Lin Chen, Ai-Zheng Chen та ін. "Preparation and characteristics of novel poly-L-lactide/β-calcium metaphosphate fracture fixation composite rods". Journal of Materials Research 22, № 12 (2007): 3324–29. http://dx.doi.org/10.1557/jmr.2007.0435.

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A kind of novel poly-L-lactide (PLLA)/β-calcium metaphosphate (β-CMP) fracture-fixation composite rod was prepared by a two-step compression-molding method. The in vitro bioactivity of the composite rod was evaluated by investigating the effects of dissolved products from the composite rod on osteoblasts. In addition, the in vitro biocompatibility of the composite rod was evaluated by an osteoblast adhesion-and-proliferation assay. The products from composite rod dissolution significantly promoted cell growth. Furthermore, osteoblasts adhered and spread well on the rod. This PLLA/β-CMP composi

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Charoenphandhu, Narattaphol, Jarinthorn Teerapornpuntakit, Methajit Methawasin, Kannikar Wongdee, Kanogwun Thongchote, and Nateetip Krishnamra. "Prolactin decreases expression of Runx2, osteoprotegerin, and RANKL in primary osteoblasts derived from tibiae of adult female rats." Canadian Journal of Physiology and Pharmacology 86, no. 5 (2008): 240–48. http://dx.doi.org/10.1139/y08-037.

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Hyperprolactinemia caused by physiological or pathological conditions, such as those occurring during lactation and prolactinoma, respectively, results in progressive osteopenia. The underlying mechanisms, however, are controversial. Prolactin (PRL) may directly attenuate the functions of osteoblasts, since these bone cells express PRL receptors. The present study therefore aimed to investigate the effects of PRL on the expression of genes related to the osteoblast functions by using quantitative real-time PCR technique. Herein, we used primary osteoblasts that were derived from the tibiae of

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Wang, Peihuan, Pengyan Qiao, Helin Xing, Rong Zhang, E. Lingling, and Hongchen Liu. "Cytotoxicity, Oxidative Stress, and Autophagy Effects of Tantalum Nanoparticles on MC3T3-E1 Mouse Osteoblasts." Journal of Nanoscience and Nanotechnology 20, no. 3 (2020): 1417–24. http://dx.doi.org/10.1166/jnn.2020.17158.

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As a bone implant material, porous tantalum (Ta) has better corrosion resistance and more suitable elastic modulus than titanium. Surface nanomodification can accelerate the integration of Ta implants with bone tissue, which has broad application prospects in the field of dental implantology. Due to mechanical stress and load wear, nanoscale Ta fragments are inevitably exfoliated from the implant surface and brought into direct contact with osteoblasts surrounding the implant. These wear fragments may affect the biological characteristics of osteoblasts and thus the stability of implants. To d

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Skelton, Anne M., D. Joshua Cohen, Barbara D. Boyan, and Zvi Schwartz. "Osteoblast-Derived Matrix Vesicles Exhibit Exosomal Traits and a Unique Subset of microRNA: Their Caveolae-Dependent Endocytosis Results in Reduced Osteogenic Differentiation." International Journal of Molecular Sciences 24, no. 16 (2023): 12770. http://dx.doi.org/10.3390/ijms241612770.

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Matrix vesicles (MVs) are nano-sized extracellular vesicles that are anchored in the extracellular matrix (ECM). In addition to playing a role in biomineralization, osteoblast-derived MVs were recently suggested to have regulatory duties. The aims of this study were to establish the characteristics of osteoblast-derived MVs in the context of extracellular vesicles like exosomes, assess their role in modulating osteoblast differentiation, and examine their mechanism of uptake. MVs were isolated from the ECM of MG63 human osteoblast-like cell cultures and characterized via enzyme activity, trans

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Maccarinelli, Giuseppina, Valeria Sibilia, Antonio Torsello, et al. "Ghrelin regulates proliferation and differentiation of osteoblastic cells." Journal of Endocrinology 184, no. 1 (2005): 249–56. http://dx.doi.org/10.1677/joe.1.05837.

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It has previously been reported that growth hormone secretagogues (GHS) may have a role in the regulation of bone metabolism in animals and humans. In this study we evaluated the effect of ghrelin, the endogenous ligand of GHS receptors, on the proliferation rate and on osteoblast activity in primary cultures of rat calvaria osteoblasts. In the same experiments, we compared the effects of ghrelin with those of hexarelin (HEXA) and EP-40737, two synthetic GHS with different characteristics. Both ghrelin and HEXA (10−11−10−8 M) significantly stimulated osteoblast proliferation at low concentrati

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Rawson, Monica, Warren Haggard, and Jessica A. Jennings. "Osteocompatibility of Biofilm Inhibitors." Open Orthopaedics Journal 8, no. 1 (2014): 442–49. http://dx.doi.org/10.2174/1874325001408010442.

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The demand for infection prevention therapies has led to the discovery of several biofilm inhibitors. These inhibiting signals are released by bacteria, fungi, or marine organisms to signal biofilm dispersal or disruption in Gram-positive, Gram-negative, and fungal microorganisms. The purpose of this study was to test the biocompatibility of five different naturally-produced biofilm chemical dispersal and inhibition signals with osteoblast-like cells: D-amino acids (D-AA), lysostaphin (LS), farnesol, cis-2-decenoic acid (C2DA), and desformyl flustrabromine (dFBr). In this preliminary study, co

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Gunnet, JW, K. Granger, E. Cryan, and KT Demarest. "Characterization of the progestin receptors in the human TE85 and murine MC3T3-E1 osteoblast-like cell lines." Journal of Endocrinology 163, no. 1 (1999): 139–47. http://dx.doi.org/10.1677/joe.0.1630139.

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Progestins are believed to exert positive effects on bone density through receptors located in osteoblasts. In the present studies, the binding characteristics and regulation of the progestin receptors in two osteoblast-like cell lines were compared with those in human breast lines. Human TE85 and murine MC3T3-E1 osteoblast-like cells contain a single, high-affinity progestin binding site whose affinity and concentration are lower than in human breast cells. The osteoblastic progestin binding sites showed the expected steroid specificity and associated with the cell nuclei when occupied by lig

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Devi Rianti, Noor Zain Salsabilla Prabowo, Maryama Aflaha, Titien Hary Agustantina, and Adriansyah syahrom. "Application of chitosan-gelatin-carbonate hydroxy apatite scaffold toward the number of osteoblasts in alveolar bone defects in Wistar Rats." World Journal of Advanced Research and Reviews 18, no. 3 (2023): 768–75. http://dx.doi.org/10.30574/wjarr.2023.18.3.0840.

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Tooth extraction may cause bone defects that require regenerative therapy. Chitosan, gelatin, and carbonate hydroxyapatite can help increase osteoblast proliferation and differentiation, which plays a role in the bone regeneration process. Scaffold made from chitosan-gelatin carbonate hydroxyapatite has promising characteristics that may help enhance the bone regeneration process. This study aimed to determine the effect of chitosan-gelatin carbonate hydroxyapatite (CG:CHA) scaffold application towards the number of osteoblasts on alveolar bone defect in Wistar rats after tooth extraction. In

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Devi, Rianti, Zain Salsabilla Prabowo Noor, Aflaha Maryama, Hary Agustantina Titien, and Adriansyah. "Application of chitosan-gelatin-carbonate hydroxy apatite scaffold toward the number of osteoblasts in alveolar bone defects in Wistar Rats." World Journal of Advanced Research and Reviews 18, no. 3 (2023): 768–75. https://doi.org/10.5281/zenodo.8434533.

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Tooth extraction may cause bone defects that require regenerative therapy. Chitosan, gelatin, and carbonate hydroxyapatite can help increase osteoblast proliferation and differentiation, which plays a role in the bone regeneration process. Scaffold made from chitosan-gelatin carbonate hydroxyapatite has promising characteristics that may help enhance the bone regeneration process. This study aimed to determine the effect of chitosan-gelatin carbonate hydroxyapatite (CG:CHA) scaffold application towards the number of osteoblasts on alveolar bone defect in Wistar rats after tooth extraction.&nbs

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Pannone, Giuseppe, Riccardo Nocini, Angela Santoro, et al. "Expression of Beta-Catenin, Cadherins and P-Runx2 in Fibro-Osseous Lesions of the Jaw: Tissue Microarray Study." Biomolecules 12, no. 4 (2022): 587. http://dx.doi.org/10.3390/biom12040587.

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Fibrous dysplasia (FD) and hyperparathyroidism-jaw tumor syndrome (HPT-JT) are well-characterized benign bone fibro-osseous lesions. The intracellular mechanism leading to excessive deposition of fibrous tissue and alteration of differentiation processes leading to osteomalacia have not yet been fully clarified. Tissue Microarray (TMA)-based immunohistochemical expression of β-catenin, CK-AE1/AE3, Ki-67, cadherins and P-Runx2 were analyzed in archival samples from nine patients affected by FD and HPT-JT and in seven controls, with the aim of elucidating the contribution of these molecules (β-c

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Yoshizawa, Tatsuya, Fumio Takizawa, Futabako Iizawa, et al. "Homeobox Protein Msx2 Acts as a Molecular Defense Mechanism for Preventing Ossification in Ligament Fibroblasts." Molecular and Cellular Biology 24, no. 8 (2004): 3460–72. http://dx.doi.org/10.1128/mcb.24.8.3460-3472.2004.

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ABSTRACT Ligaments and tendons are comprised of tough yet flexible connective tissue. Little is known, however, about the precise characteristics of the cells in ligaments and tendons due to the absence of specific markers and cell lines. We recently reported a periodontal ligament cell line, PDL-L2, with suppressed Runx2/Osf2 transcriptional activity and an inability to form mineralized nodules. The present study demonstrates that the homeobox protein Msx2 is a key factor in suppressing those two functions. Msx2 colocalizes with Runx2/Osf2 and suppresses its activity cooperatively, acting wit

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Raybolt dos Santos, Aline, Fernando Costa e Silva, and Gloria Dulce de Almeida Soares. "The Interaction between Human Osteoblastic Cells and Titanium Anodized with Sulphuric Acid Coated or not with Human Plasma Fibronectin." Key Engineering Materials 396-398 (October 2008): 389–92. http://dx.doi.org/10.4028/www.scientific.net/kem.396-398.389.

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In this study, commercially pure titanium (Ti-cp) sheets grade 2 were used as substrates. To investigate the role of composition and characteristics of titanium surface oxides in cellular behavior of osteoblasts, the surface of titanium were modified by anodic oxidation with sulphuric acid. Subsequently were treated part of anodized samples with FN and cultured with osteoblast cells for 30, 120 and 240 minutes. The chemical composition and topography have influenced the interaction between fibronectin and substrate. Cells were found more associated to the surfaces that have been submitted to a

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Wachesk, C. C., V. J. Trava-Airoldi, N. S. Da-Silva, A. O. Lobo, and F. R. Marciano. "The Influence of Titanium Dioxide on Diamond-Like Carbon Biocompatibility for Dental Applications." Journal of Nanomaterials 2016 (2016): 1–7. http://dx.doi.org/10.1155/2016/8194516.

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The physical and chemical characteristics of diamond-like carbon (DLC) films make them suitable for implantable medical and odontological interests. Despite their good interactions with biological environment, incorporated nanoparticles can significantly enhance DLC properties. This manuscript studies the potential of titanium dioxide (TiO2) incorporated-DLC films in dental applications. In this scene, both osteoblasts attachment and spreading on the coatings and their corrosion characteristics in artificial saliva were investigated. The films were grown on 304 stainless steel substrates using

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de Lima Cavalcanti, José Henrique, Patrícia Matos, Cresus Vinícius Depes de Gouvêa, et al. "In Vitro Assessment of the Functional Dynamics of Titanium with Surface Coating of Hydroxyapatite Nanoparticles." Materials 12, no. 5 (2019): 840. http://dx.doi.org/10.3390/ma12050840.

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Manipulation of implant surface characteristics constitutes a promising strategy for improving cell growth and tissue response on a variety of materials with different surface topographies. Mesenchymal progenitor cells with a capacity to respond to titanium surface stimuli and differentiate into osteoblasts were used to perform comparative tests between two different implant topographies, including their functional interaction with pre-osteoblasts directly seeded onto the implants. Functional analysis of nanostructured implant surfaces was performed by in vitro assay analysis. The machined sur

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Torres-Hernández, Yaret, Gloria Ortega-Díaz, Lucía Téllez-Jurado, et al. "Biological Compatibility of a Polylactic Acid Composite Reinforced with Natural Chitosan Obtained from Shrimp Waste." Materials 11, no. 8 (2018): 1465. http://dx.doi.org/10.3390/ma11081465.

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The aim of this work is to evaluate the effect of chitosan content (1, 3 and 5 wt %) dispersed in polylactic acid (PLA) on the structure and properties of composites. Also, the hydrolytic degradation, and the cell viability and adhesion of human MG-63 osteoblasts are analyzed to determine the composites’ suitability for use in tissue engineering. For the manufacture of the materials, natural chitosan was extracted chemically from shrimp exoskeleton. The composites were fabricated by extrusion, because it is a low-cost process, it is reproducible, and it does not compromise the biocompatibility

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Gutiérrez-Prieto, Sandra J., Sandra J. Perdomo-Lara, José M. Diaz-Peraza, and Luis Gonzalo Sequeda-Castañeda. "Analysis of In Vitro Osteoblast Culture on Scaffolds for Future Bone Regeneration Purposes in Dentistry." Advances in Pharmacological Sciences 2019 (February 6, 2019): 1–9. http://dx.doi.org/10.1155/2019/5420752.

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One of the main focuses of tissue engineering is to search for tridimensional scaffold materials, complying with nature’s properties for tissue regeneration. Determining material biocompatibility is a fundamental step in considering its use. Therefore, the purpose of this study was to analyze osteoblast cell adhesion and viability on different materials to determine which was more compatible for future bone regeneration. Tridimensional structures were fabricated with hydroxyapatite, collagen, and porous silica. The bovine bone was used as material control. Biocompatibility was determined by se

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Zamani, Mehdi, Masoud Farahnakian, and Sadegh Elhami. "Employment of ultrasonic assisted turning in the fabrication of microtextures to improve the surface adhesion of the titanium implant." Proceedings of the Institution of Mechanical Engineers, Part B: Journal of Engineering Manufacture 235, no. 12 (2021): 1983–91. http://dx.doi.org/10.1177/09544054211011029.

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Since the presentation of the cell adhesion concept, properties of the contact surface between osteoblasts and titanium implant and possible methods to enhance related characteristics have attracted much attention in orthopedic investigations. The creation of microtextures on the titanium implant is an important method to improve cell adhesion. This research includes the employment of Ultrasonic Assisted Turning (UAT) to create special microtextures on the titanium implant. Also, the developed interfacial ratio (Sdr) are analyzed to understand the effect of main surface characteristics on the

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Osorio-Arciniega, Rodrigo, Manuel García-Hipólito, Octavio Alvarez-Fregoso, and Marco Antonio Alvarez-Perez. "Composite Fiber Spun Mat Synthesis and In Vitro Biocompatibility for Guide Tissue Engineering." Molecules 26, no. 24 (2021): 7597. http://dx.doi.org/10.3390/molecules26247597.

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Composite scaffolds are commonly used strategies and materials employed to achieve similar analogs of bone tissue. This study aims to fabricate 10% wt polylactic acid (PLA) composite fiber scaffolds by the air-jet spinning technique (AJS) doped with 0.5 or 0.1 g of zirconium oxide nanoparticles (ZrO2) for guide bone tissue engineering. ZrO2 nanoparticles were obtained by the hydrothermal method and characterized by X-ray diffraction (XRD) and scanning electron microscopy (SEM). SEM and fourier-transform infrared spectroscopy (FTIR) analyzed the synthesized PLA/ZrO2 fiber scaffolds. The in vitr

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Morse, C. C., J. E. Saik, D. W. Richardson, and A. W. Fetter. "Equine Juvenile Mandibular Ossifying Fibroma." Veterinary Pathology 25, no. 6 (1988): 415–21. http://dx.doi.org/10.1177/030098588802500603.

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Benign proliferative fibro-osseous lesions of the rostral mandible in six young horses are classified as equine juvenile mandibular ossifying fibroma. Histologically there is a characteristic abrupt transition from subgingival fibroblastic stroma to a zone of proliferating osteoblasts that form irregular spicules of osteoid. The layer of proliferating osteoblasts blends with a deeper zone of bony trabeculae rimmed by osteoblasts and separated by intertrabecular spaces of moderate cellular density. Incomplete surgical excision resulted in local recurrence, while rostral mandibulectomies resulte

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Barrio, Daniel A., Elizabeth R. Cattáneo, María C. Apezteguía, and Susana B. Etcheverry. "Vanadyl(IV) complexes with saccharides. Bioactivity in osteoblast-like cells in cultureThis paper is one of a selection of papers published in this Special issue, enititled Second Messengers and Phosphoproteins—12th International Conference." Canadian Journal of Physiology and Pharmacology 84, no. 7 (2006): 765–75. http://dx.doi.org/10.1139/y06-021.

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Complexes of vanadyl(IV) with 4 monosaccharides and 5 disaccharides were tested in 2 osteoblast-like cell lines (MC3T3E1 and UMR106). Many complexes caused stimulation of UMR106 proliferation (120% basal) in the range of 2.5 to 25 µmol/L. In the nontransformed osteoblasts, some vanadyl–saccharide complexes stimulated the mitogenesis (115% basal) in the same range of concentration. The glucose and sucrose complexes were the most efficient inhibitory agents (65% and 88% of inhibition vs. basal, respectively) for tumoral cells at 100 µmol/L. The galactose and turanose complexes exerted a similar

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Ehnert, Sabrina, Romina Haydée Aspera-Werz, Thomas Freude, et al. "Distinct Gene Expression Patterns Defining Human Osteoblasts' Response to BMP2 Treatment: Is the Therapeutic Success All a Matter of Timing?" European Surgical Research 57, no. 3-4 (2016): 197–210. http://dx.doi.org/10.1159/000447089.

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Background: Bone morphogenetic proteins (BMPs) play a key role in bone formation. Local application of BMP2 (Dibotermin alfa) supports bone formation when applied to complex fractures. However, up to 33% of patients do not respond to this therapy. Purpose: Aiming to investigate whether inter-individual responses to BMP2 treatment can be predicted by gene expression patterns, we investigated the effect of BMP2 on primary human osteoblasts and THP-1 cell-derived osteoclasts from 110 donors. Methods: Osteoblasts were obtained by collagenase digestion of spongy bone tissues. Osteoclasts were diffe

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Barbeck, Mike, Marie-Luise Schröder, Said Alkildani, Ole Jung, and Ronald E. Unger. "Exploring the Biomaterial-Induced Secretome: Physical Bone Substitute Characteristics Influence the Cytokine Expression of Macrophages." International Journal of Molecular Sciences 22, no. 9 (2021): 4442. http://dx.doi.org/10.3390/ijms22094442.

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In addition to their chemical composition various physical properties of synthetic bone substitute materials have been shown to influence their regenerative potential and to influence the expression of cytokines produced by monocytes, the key cell-type responsible for tissue reaction to biomaterials in vivo. In the present study both the regenerative potential and the inflammatory response to five bone substitute materials all based on β-tricalcium phosphate (β-TCP), but which differed in their physical characteristics (i.e., granule size, granule shape and porosity) were analyzed for their ef

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TSAI, SHIAO-WEN, FU-YIN HSU, and YNG JIIN WANG. "ENCAPSULATION AND GROWTH CHARACTERISTICS OF THREE DIFFERENT CELLS IN ALGINATE GEL BEADS CONTAINING RECONSTITUTED COLLAGEN FIBERS." Biomedical Engineering: Applications, Basis and Communications 18, no. 02 (2006): 62–66. http://dx.doi.org/10.4015/s1016237206000129.

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Alginate gel beads containing reconstituted collagen fibers were fabricated and used to culture three different cells - GH3 pituitary tumor cells, L929 fibroblasts and rat calvaria osteoblasts. These cells when entrapped within the collagen-containing alginate behaved differently from those grown in the alginate matrix. Of the three cells tested, the existence of collagen fibers is most beneficial for the viability and proliferation of GH3 cells which can grow either as suspended or attached to the matrix. For the case of osteoblasts derived from the primary culture of rat calvaria, most of th

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Koutsilieris, M., S. A. Rabbani, and D. Goltzman. "Effects of human prostatic mitogens on rat bone cells and fibroblasts." Journal of Endocrinology 115, no. 3 (1987): 447—NP. http://dx.doi.org/10.1677/joe.0.1150447.

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ABSTRACT We examined several characteristics of the mitogenic activity of extracts of human prostatic adenocarcinoma and human benign prostatic hyperplasia in fetal rat calvarial cells, cloned rat osteosarcoma cells and rat skin fibroblasts. Prostatic moieties produced maximal stimulation of [3H]thymidine incorporation at 24 h, were mitogenic in the absence or presence of various concentrations of serum, and were active in calvarial cells enriched with osteoblasts, skin fibroblasts and the cloned rat osteosarcoma cell line UMR 108. The known growth-promoting agents insulin, insulin-like growth

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Xu, Y. "Effects of sophoricoside and genistein on biological characteristics of osteoblasts." Journal of Chinese Integrative Medicine 7, no. 3 (2009): 223–27. http://dx.doi.org/10.3736/jcim20090305.

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Jiang, S. Y., R. Shu, Y. F. Xie, and S. Y. Zhang. "Age-related changes in biological characteristics of human alveolar osteoblasts." Cell Proliferation 43, no. 5 (2010): 464–70. http://dx.doi.org/10.1111/j.1365-2184.2010.00696.x.

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Gay, Carol V., Qin P. Lloyd, and Virginia R. Gilman. "Characteristics and culture of osteoblasts derived from avian long bone." In Vitro Cellular & Developmental Biology - Animal 30, no. 6 (1994): 379–83. http://dx.doi.org/10.1007/bf02634358.

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Ichioka, Yuki, Farah Asa'ad, Behnosh Öhrnell Malekzadeh, Anna Westerlund, and Lena Larsson. "Epigenetic changes of osteoblasts in response to titanium surface characteristics." Journal of Biomedical Materials Research Part A 109, no. 2 (2020): 170–80. http://dx.doi.org/10.1002/jbm.a.37014.

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Benz, Korbinian, Andreas Schöbel, Marisa Dietz, Peter Maurer, and Jochen Jackowski. "Adhesion Behaviour of Primary Human Osteoblasts and Fibroblasts on Polyether Ether Ketone Compared with Titanium under In Vitro Lipopolysaccharide Incubation." Materials 12, no. 17 (2019): 2739. http://dx.doi.org/10.3390/ma12172739.

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The aim of this in vitro pilot study was to analyse the adhesion behaviour of human osteoblasts and fibroblasts on polyether ether ketone (PEEK) when compared with titanium surfaces in an inflammatory environment under lipopolysaccharide (LPS) incubation. Scanning electron microscopy (SEM) images of primary human osteoblasts/fibroblasts on titanium/PEEK samples were created. The gene expression of the LPS-binding protein (LBP) and the LPS receptor (toll-like receptor 4; TLR4) was measured by real-time polymerase chain reaction (PCR). Immunocytochemistry was used to obtain evidence for the dist

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Arai, Fumio, Yuka Nakamura, Kentaro Hosokawa, et al. "Fractionated Osteoblastic Niche Cells Enhances the Homing Activity of Hematopoietic Stem Cells." Blood 114, no. 22 (2009): 560. http://dx.doi.org/10.1182/blood.v114.22.560.560.

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Abstract Abstract 560 Hematopoietic stem cells (HSCs) retain quiescent state in the adult bone marrow (BM), interacting with specialized niches along the endosteum (osteoblastic niche) and in perivascular sites adjacent to endothelial and reticular cells (perivascular niche). We have previously reported that the regulations of HSCs in the osteoblastic niche through the receptor-cytokine, cell-to-cell, and cell-to-extracellular matrix (ECM) interactions are critical for the maintenance of cell cycle quiescence. However, osteoblast population is heterogeneous in terms of the degree of differenti

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Barille, S., M. Collette, R. Bataille, and M. Amiot. "Myeloma cells upregulate interleukin-6 secretion in osteoblastic cells through cell-to-cell contact but downregulate osteocalcin." Blood 86, no. 8 (1995): 3151–59. http://dx.doi.org/10.1182/blood.v86.8.3151.3151.

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Abstract Previous studies have shown that bone marrow, especially the bone microenvironment, may play an important role in the pathogenesis of multiple myeloma (MM). To elucidate the relationship between myeloma cells and bone cells, mainly osteoblasts, we have established a coculture system between two interleukin-6 (IL-6)-dependent myeloma cell lines, XG1 and XG6, and the osteosarcoma cell lines Saos-2 and MG63. Both osteosarcoma cell lines have retained major functions of normal osteoblasts; principally, the capacity to produce hematopoietic growth factors (including IL-6) and osteocalcin,

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Barille, S., M. Collette, R. Bataille, and M. Amiot. "Myeloma cells upregulate interleukin-6 secretion in osteoblastic cells through cell-to-cell contact but downregulate osteocalcin." Blood 86, no. 8 (1995): 3151–59. http://dx.doi.org/10.1182/blood.v86.8.3151.bloodjournal8683151.

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Previous studies have shown that bone marrow, especially the bone microenvironment, may play an important role in the pathogenesis of multiple myeloma (MM). To elucidate the relationship between myeloma cells and bone cells, mainly osteoblasts, we have established a coculture system between two interleukin-6 (IL-6)-dependent myeloma cell lines, XG1 and XG6, and the osteosarcoma cell lines Saos-2 and MG63. Both osteosarcoma cell lines have retained major functions of normal osteoblasts; principally, the capacity to produce hematopoietic growth factors (including IL-6) and osteocalcin, a noncoll

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Son, Young-Bum, Yeon Ik Jeong, Yeon Woo Jeong, et al. "Comparative Study of Biological Characteristics, and Osteoblast Differentiation of Mesenchymal Stem Cell Established from Camelus dromedarius Skeletal Muscle, Dermal Skin, and Adipose Tissues." Animals 11, no. 4 (2021): 1017. http://dx.doi.org/10.3390/ani11041017.

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Mesenchymal stem cells (MSCs) showed in vitro mesoderm-lineage differentiation and self-renewal capacity. However, no comparative study was reported on the biological characteristics of stem cells derived from skeletal muscle (SM-MSCs), dermal skin (DS-MSCs), and adipose tissues (A-MSCs) from a single donor in camels. The present study aimed to evaluate the influence of MSCs source on stem cell characteristics. We evaluated proliferation capacity and mesoderm-lineage differentiation potential from SM-MSCs, DS-MSCs, and A-MSCs. They showed spindle-like morphology after homogenization. The proli

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Su, Hengjie, Tomoko Fujiwara, Omar Skalli, et al. "Porous Nano-Fiber Structure of Modified Electrospun Chitosan GBR Membranes Improve Osteoblast Calcium Phosphate Deposition in Osteoblast-Fibroblast Co-Cultures." Marine Drugs 22, no. 4 (2024): 160. http://dx.doi.org/10.3390/md22040160.

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Desirable characteristics of electrospun chitosan membranes (ESCM) for guided bone regeneration are their nanofiber structure that mimics the extracellular fiber matrix and porosity for the exchange of signals between bone and soft tissue compartments. However, ESCM are susceptible to swelling and loss of nanofiber and porous structure in physiological environments. A novel post-electrospinning method using di-tert-butyl dicarbonate (tBOC) prevents swelling and loss of nanofibrous structure better than sodium carbonate treatments. This study aimed to evaluate the hypothesis that retention of n

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Scimeca, Manuel, Nicoletta Urbano, Bonfiglio Rita, et al. "Prostate Osteoblast-Like Cells: A Reliable Prognostic Marker of Bone Metastasis in Prostate Cancer Patients." Contrast Media & Molecular Imaging 2018 (December 9, 2018): 1–12. http://dx.doi.org/10.1155/2018/9840962.

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The main aim of this study was to investigate the putative association among the presence of prostate cancer cells, defined as prostate osteoblast-like cells (POLCs), and showing the expression of typical morphological and molecular characteristics of osteoblasts, the development of bone metastasis within 5 years of diagnosis, and the uptake of 18F-choline evaluated by PET/CT analysis. To this end, prostate biopsies (n= 110) were collected comprising 44 benign lesions and 66 malignant lesions. Malignant lesions were further subdivided into two groups: biopsies from patients that had clinical e

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Carnovali, Marta, Giuseppe Banfi, and Massimo Mariotti. "Molecular Hydrogen Prevents Osteoclast Activation in a Glucocorticoid-Induced Osteoporosis Zebrafish Scale Model." Antioxidants 12, no. 2 (2023): 345. http://dx.doi.org/10.3390/antiox12020345.

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Antioxidants represent a powerful tool for many human diseases and, in particular, molecular hydrogen has unique characteristics that make it a very promising therapeutic agent against osteoporosis. Zebrafish scales offer an innovative model in which new therapeutic approaches against secondary osteoporosis are tested. Scale bone loss obtained by prednisolone (PN) treatment is characterized by increased osteoclast activity and decreased osteoblast activity highlighted with bone enzymatic assays. We used this read-out system to test the therapeutic effects of hydrogen-rich water (HRW), an innov

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Pierfelice, Tania Vanessa, Emira D’Amico, Simonetta D’Ercole, et al. "Functionalization of A Cortical Membrane with a Photodynamic Protocol." Journal of Functional Biomaterials 14, no. 3 (2023): 133. http://dx.doi.org/10.3390/jfb14030133.

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Guided bone regeneration (GBR) comprehends the application of membranes to drive bone healing and to exclude non-osteogenic tissues from interfering with bone regeneration. However, the membranes may be exposed to bacterial attack, with the risk of failure of the GBR. Recently, an antibacterial photodynamic protocol (ALAD-PDT) based on a gel with 5% 5-aminolevulinic acid incubated for 45 min and irradiated for 7 min by a LED light at 630 nm, also showed a pro-proliferative effect on human fibroblasts and osteoblasts. The present study hypothesized that the functionalization of a porcine cortic

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Abuarqoub, Duaa A., Nazneen Aslam, Raghda B. Barham, et al. "The effect of platelet lysate in culture of PDLSCs: an in vitro comparative study." PeerJ 7 (August 8, 2019): e7465. http://dx.doi.org/10.7717/peerj.7465.

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Background Cellular therapy clinical applications require large-scale production of stem cells. Therefore, abundance, ease of isolation, and proliferative potential are the most important factors in choosing the appropriate source of cells for transplantation studies. Multipotent stem cells obtained from periodontal ligament (PDL) can be used in periodontal tissue regeneration. In this study, we aimed to evaluate and compare the characteristics of periodontal ligament stem cells (PDLSCs), extracted by either enzymatic digestion or explant methods, and expanded using two different serum types:

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Novello, Solen, Sylvie Tricot-Doleux, Agnès Novella, Pascal Pellen-Mussi, and Sylvie Jeanne. "Influence of Periodontal Ligament Stem Cell-Derived Conditioned Medium on Osteoblasts." Pharmaceutics 14, no. 4 (2022): 729. http://dx.doi.org/10.3390/pharmaceutics14040729.

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Mesenchymal stem cells (MSC) are involved in the regeneration of various missing or compromised periodontal tissues, including bone. MSC-derived conditioned medium (CM) has recently been explored as a favorable surrogate for stem cell therapy, as it is capable of producing comparable therapeutic effects. This study aimed to evaluate the influence of periodontal ligament stem cells (PDLSC)-CM on osteoblasts (OB) and its potential as a therapeutic tool for periodontal regeneration. Human PDLSC were isolated and characterized, and CM from these cells was collected. The presence of exosomes in the

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Béréziat, Véronique, Christelle Mazurier, Martine Auclair, et al. "Systemic Dysfunction of Osteoblast Differentiation in Adipose-Derived Stem Cells from Patients with Multiple Myeloma." Cells 8, no. 5 (2019): 441. http://dx.doi.org/10.3390/cells8050441.

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Multiple myeloma is characterized by bone lesions linked to increased osteoclast and decreased osteoblast activities. In particular, the osteoblast differentiation of bone marrow-derived stem cells (MSC) is impaired. Among the potential therapeutic tools for counteracting bone lesions, adipose-derived stem cells (ASC) could represent an appealing source for regenerative medicine due to their similar characteristics with MSC. Our study is among the first giving detailed insights into the osteoblastogenic capacities of ASC isolated by fat aspiration from myeloma patients (MM-ASC) compared to hea

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Lin, Y., W. Lian, Y. Chen, and F. Wang. "EXERKINE FNDC5 PRESERVES BONE ANABOLISM AND COUNTERACTS OESTROGEN DEFICIENCY-INDUCED OSTEOPOROSIS DEVELOPMENT." Orthopaedic Proceedings 106-B, SUPP_18 (2024): 124. http://dx.doi.org/10.1302/1358-992x.2024.18.124.

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IntroductionOsteoporosis accounts for a major risk factor of fracture-associated disability or premature death in the elderly. Enhancement of bone anabolism for slowing osteoporosis is highly demanding. Exerkine fibronectin type III domain containing 5 (FNDC5) regulates energy metabolism, inflammation, and aging. This study was aimed to investigate whether Fndc5 signaling in osteoblasts changed estrogen deficiency-mediated bone loss or microarchitecture deterioration.MethodFemale osteoblast-specific Fndc5 transgenic mice (Fndc5Tg), which overexpressed Fndc5 under the control of key osteoblast

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Jeanblanc, Christine Michelle, Evan Colletti, Christopher D. Porada, Graca Almeida-Porada, and Esmail D. Zanjani. "Defining the Development of Receptive Niches for in Utero Transplantation of Hematopoietic Stem Cells." Blood 114, no. 22 (2009): 3527. http://dx.doi.org/10.1182/blood.v114.22.3527.3527.

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Abstract Abstract 3527 Poster Board III-464 In utero hematopoietic stem cell transplantation (IUSCT) is a promising therapeutic alternative to postnatal stem cell transplantation which could potentially provide successful treatment for many genetic and developmental diseases affecting the immune and hematopoietic systems. Advances in molecular biological techniques and improvements in obstetrical procedures such as chorionic villous sampling now permit the collection of fetal material and the diagnosis of genetic disorders early enough in gestation to allow the use of IUSCT to treat these dise

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Kang, Yeon-Ho, Bohm Choi, Chihyun Ahn, Seunghan Oh, Myeung Soo Lee, and Eun-Jung Jin. "Titanium Oxide Nanotube Surface Topography and MicroRNA-488 Contribute to Modulating Osteogenesis." Journal of Nanomaterials 2014 (2014): 1–8. http://dx.doi.org/10.1155/2014/589710.

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Understanding the biocomplexity of cell behavior in relation to the topographical characteristics of implants is essential for successful osseointegration with good longevity and minimum failure. Here, we investigated whether culture on titanium oxide (TiO2) nanotubes of various diameters could affect the behavior and differentiation of MC3T3-E1 cells. Among the tested nanotubes, those of 50 nm in diameter were found to trigger the expression of the osteoblast-specific transcription factors, sp7 and Dlx5, and upregulate the expression of alkaline phosphatase (ALP). Here, we report that miR-488

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Huang, He, Jing Zheng, Xiaoyu Lai, Junli Cao, and Jianling Fan. "Biological Characteristics of ZUC3 Antigen Expressed on Rat Bone Marrow Mesenchymal Stem Cells." Blood 108, no. 11 (2006): 4254. http://dx.doi.org/10.1182/blood.v108.11.4254.4254.

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Abstract Objective: Bone marrow mesenchymal stem cells (MSCs) are widely studied in recent years. As an important part of cell identification, specific surface markers of MSCs have been paid a lot of attention to for long, but no breakthrough as yet. Monoclonal antibodies (McAb) against surface of certain cells have been used to characterize cell lineages. ZUC3, a novel murine McAb was produced by hybridoma technology previously, which was specifically reactive with both human MSCs and rat MSCs. Studying the expression of ZUC3 antigen on rat MSCs after passage and differentiation, it was to de

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Yao, Chun-Hsu, Bai-Shuan Liu, Chau-Guey Liu, and Yueh-Sheng Chen. "Osteogenic Potential Using a Malleable, Biodegradable Composite Added Traditional Chinese Medicine: in vitro and in vivo Evaluations." American Journal of Chinese Medicine 34, no. 05 (2006): 873–86. http://dx.doi.org/10.1142/s0192415x06004351.

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The purpose of this investigation was to prepare and evaluate the feasibility and biocompatibility of a new composite as a large defect bone substitute. The new GTGG was mainly composed of tricalcium phosphate ceramic particles and glutaraldehyde crosslinked gelatin in which Gui-Lu-Jiao was added (a mixture of Cervi Colla Cornus and Colla Plastri Testudinis). In the in vitro study, rat's calvaria osteoblasts were used to study bone characteristics upon exposure to different concentrations of the Gui-Lu-Jiao solution. In the in vivo study, GTGG composites were implanted into the defects of calv

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Esmaeilian, Yashar, Arzu Atalay, and Esra Erdemli. "Putative germline and pluripotent stem cells in adult mouse ovary and their in vitro differentiation potential into oocyte-like and somatic cells." Zygote 25, no. 3 (2017): 358–75. http://dx.doi.org/10.1017/s0967199417000235.

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SummaryAccording to classical knowledge of reproductive biology, in the ovary of female mammals there is a limited number of oocytes and there is no possibility of renewal if the oocytes are lost due to disease or injury. However, in recent years, the results of some studies on renewal and formation of oocytes and follicles in the adult mammalian ovary have led to the questioning of this opinion. The aim of our study is to demonstrate the presence of putative germline and pluripotent stem cells in the adult mouse ovary and their differentiation potential into germ and somatic cells. In ovary t

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Lee, Yong-Bae, Seong-Jin Lee, Suk-Joo You, Hyun-A. Kim, Hyung-Keun You, and Hyung-Shik Shin. "Study on the Biological Characteristics of Cultured Osteoblasts Derived from Alveolar Bone." Journal of the Korean Academy of Periodontology 34, no. 2 (2004): 317. http://dx.doi.org/10.5051/jkape.2004.34.2.317.

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