Log in

Relevant bibliographies by topics / Characterization of piperazino / Journal articles

To see the other types of publications on this topic, follow the link: Characterization of piperazino.

Journal articles on the topic 'Characterization of piperazino'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 journal articles for your research on the topic 'Characterization of piperazino.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

N., Kalarani, Angumeenal AR., Kamalakannan P., and Venkappayya D. "Synthesis and characterization of piperazino-bis(methylantipyrine) and its complexes with chromium(III), manganese(II), cobalt(II), copper(II), zinc(II) and cadmium(II) ions." Journal of Indian Chemical Society Vol. 82, May 2005 (2005): 404–10. https://doi.org/10.5281/zenodo.5829979.

Full text

Abstract:

Department of Chemistry, National Institute or Technology, Tiruchirappalli-620 015, India School of Chemical and Biotechnology, SASTRA Deemed University, Thanjavur-613 402. India <em>E-mail</em> : angum@nitt.edu <em>Manuscript received 3 September 2003, revised 23 June 2004, accepted 2 February 2005</em> A new Mannich base, piperazino-his(methylantipyrine) (PBMA), was synthesized and characterized by spectral studies. Chelates of PBMA with chromium(III), manganese(ll), cobalt(II), copper(II), zinc(II) and cadmium(II) ions were prepared and characterized by elemental analyses and IR, UV and <su

APA, Harvard, Vancouver, ISO, and other styles

2

Skov, Joan, Torsten Bryld, Dorthe Lindegaard, et al. "Synthesis and structural characterization of piperazino-modified DNA that favours hybridization towards DNA over RNA." Nucleic Acids Research 39, no. 5 (2010): 1953–65. http://dx.doi.org/10.1093/nar/gkq1123.

Full text

APA, Harvard, Vancouver, ISO, and other styles

3

Little, Vanessa Renee, and Keith Vaughan. "Synthesis and characterization of several series of 4-acyl-1-[2-aryl-1-diazenyl]piperazines." Canadian Journal of Chemistry 92, no. 9 (2014): 838–48. http://dx.doi.org/10.1139/cjc-2014-0242.

Full text

Abstract:

Five series of a novel class of 4-acyl-1-[2-aryl-1-diazenyl]piperazines have been synthesized and characterized: the 4-acetyl-1-[2-aryl-1-diazenyl]piperazines [series 1]; the 4-cyclohexylcarbonyl-1-[2-aryl-1-diazenyl]piperazines [series 2]; the 4-benzoyl-1-[2-aryl-1-diazenyl]piperazines [series 3]; the benzyl 4-[2-aryl-1-diazenyl]-1-piperazinecarboxylates [series 4]; and the t-butyl 4-[2-aryl-1-diazenyl]-1-piperazinecarboxylates [series 5]. The compounds were synthesized by diazotization of a primary aromatic amine and subsequent coupling to an appropriate secondary amine: 1-acetylpiperazine [

APA, Harvard, Vancouver, ISO, and other styles

4

O’Malley, Karen, and Keith Vaughan. "Synthesis and Characterization of a Series of 1-Aryl-4-[Aryldiazenyl]-piperazines. Part II1. 1-Aryl-4-(2-Aryl-1-Diazenyl)-piperazines with Fluoro-, chloro-, Methyl-, Cyano- and Acetyl Substituents in The 1-Aryl Group." Open Chemistry Journal 3, no. 1 (2016): 42–55. http://dx.doi.org/10.2174/1874842201603010042.

Full text

Abstract:

This paper reports the synthesis and characterization of eight series of 1-aryl-4-(2-aryl-1-diazenyl)-piperazines (12 to 19). Several series of these triazenes have been synthesized by the diazotization of a primary arylamine followed by diazonium coupling with a secondary arylpiperazine . The arylpiperazines used in this study are: 1-phenylpiperazine, 1-(4-fluorophenyl-)piperazine, 1-(4-chlorophenyl-)piperazine, 1-(3,4-dichlorophenyl-)piperazine, 1-(2-methylphenyl-)-piperazine, 1-(4-acetophenyl-)-piperazine, 1-(2-pyridyl-)piperazine and 2-cyanophenylpiperazine. These new triazenes (series 12-

APA, Harvard, Vancouver, ISO, and other styles

5

Little, Vanessa Renée, Reid Tingley, and Keith Vaughan. "Triazene derivatives of (1,x)-diazacycloalkanes. Part III. Synthesis and characterization of a series of 1,4-di[2-aryl-1-diazenyl]piperazines." Canadian Journal of Chemistry 83, no. 5 (2005): 471–76. http://dx.doi.org/10.1139/v05-064.

Full text

Abstract:

Reaction of a series of diazonium salts with piperazine in a 2:1 molar ratio affords excellent yields of the 1,4-di-[2-aryl-1-diazenyl]piperazines (3), which have been characterized by IR and NMR spectroscopy. Structural characterization is supported by elemental analysis or by mass spectrometry with accurate mass measurement of the molecular ion. The protons of the piperazine ring hydrogens give rise to a sharp singlet at ca. 4 ppm in the NMR spectra, indicating that the conformational equilibrium in the piperazine ring is rapid on the NMR timescale. The four equivalent carbon atoms of the pi

APA, Harvard, Vancouver, ISO, and other styles

6

Zhang, Gang, and Courtney C. Aldrich. "Macozinone: revised synthesis and crystal structure of a promising new drug for treating drug-sensitive and drug-resistant tuberculosis." Acta Crystallographica Section C Structural Chemistry 75, no. 8 (2019): 1031–35. http://dx.doi.org/10.1107/s2053229619009185.

Full text

Abstract:

Mycobacterium tuberculosis (Mtb), the principal etiological agent of tuberculosis (TB), infects over one-quarter of humanity and is now the leading cause of infectious disease mortality by a single pathogen. Macozinone {2-[4-(cyclohexylmethyl)piperazin-1-yl]-8-nitro-6-(trifluoromethyl)-4H-1,3-benzothiazin-4-one, C20H23F3N4O3S} is a promising new drug for treating drug-sensitive and drug-resistant TB that has successfully completed phase I clinical trials. We report the complete spectroscopic and structural characterization by 1H NMR, 13C NMR, HRMS, IR, and X-ray crystallography. The cyclohexyl

APA, Harvard, Vancouver, ISO, and other styles

7

Hussien, Nasry Jassim, Jasim M. S. Alshawi, Khalid Tuama Abdullah, Enaam I. Yousif, and Mohamad J. Al-Jeboori. "Dimethyltin (IV) complexes of new thiosemicarbazone ligand with piperazine-1-yimethylene moiety: Synthesis, spectral characterization and antibacterial activity." Edelweiss Applied Science and Technology 9, no. 3 (2025): 266–78. https://doi.org/10.55214/25768484.v9i3.5202.

Full text

Abstract:

Three new thiosemicarbazone ligands and their dimethyltin (IV) complexes are reported. The condensation of piperazine-1-carbaldehyde with thiosemicarbazide, 4-methyl-3-thiosemicarbazide, and 4-ethyl-3-thiosemicarbazide was carried out in an ethanol medium using HBr as a catalyst, resulting in the isolation of the ligands (E)-2-(piperazin-1-ylmethylene) hydrazine-1-carbothioamide (HL1), (E)-N-methyl-2-(piperazin-1-ylmethylene) hydrazine-1-carbothioamide (HL2), and (E)-N-ethyl-2-(piperazin-1-ylmethylene) hydrazine-1-carbothioamide (HL3), respectively. The reaction of ligands HL1 - HL3 with dimet

APA, Harvard, Vancouver, ISO, and other styles

8

Hulinská, Hana, Zdeněk Polívka, Jiří Jílek, et al. "Experimental antiulcer agents: N-substituted 2-(4-methyl-1-piperazinyl)acetamides as pirenzepine models and some related compounds." Collection of Czechoslovak Chemical Communications 53, no. 8 (1988): 1820–44. http://dx.doi.org/10.1135/cccc19881820.

Full text

Abstract:

Reactions of N-cyclohexyl-2-chloroacetamide, N-phenyl-2-chloroacetamide, N-(4-dimethylaminophenyl)-2-chloroacetamide, N-(2-nitrophenyl)-N-phenyl-2-chloroacetamide, its 3-nitrophenyl and 4-nitrophenyl analogues, N-(2-benzylphenyl)-2-chloroacetamide, 5-(chloroacetyl)-dibenz[b,f]azepine, and its 10,11-dihydro derivative with piperazine, 1-methylpiperazine, 2-(1-piperazinyl)ethanol, and 3-(1-piperazinyl)propanol resulted in compounds II, III, V-XV, XVIII, XXI, and XXIII, simple analogues of the antiulcer agent pirenzepine (I). Contributions to the syntheses and characterization of mianserin (XIX),

APA, Harvard, Vancouver, ISO, and other styles

9

Raad, Saad Jihad, Abed Abdul-Reda Nabeel та Mousa Juda Al-Shamari Amer. "Synthesis, characterization and molecular docking of new deriva-tives that contain quіnoxazlіne moities and study antioxidant prop-erties". Pakistan Journal of Analytical & Environmental Chemistry 23, Special Issue (2023): 174–88. https://doi.org/10.5281/zenodo.7702678.

Full text

Abstract:

<strong>   Abstract </strong>     In this study we are prepared some novel derivatives from cetirizine Impurity A by react 1-((4-chlorophenyl)(phenyl) methyl)piperazine with 2-chloro acetyl chloride to prepared 2-chloro-1-(4-((4-chlorophenyl)(phenyl)methyl)piperazin-1-yl)ethan-1-one (1) from this directive prepared the derivatives (2-6) when react with o-phenylenediamine derivatives to obtain analytically pure quinoxaline derivatives .The reaction was monitored by thin‐layer chromatography (TLC) technique. All new compounds were characterized by melting points, element

APA, Harvard, Vancouver, ISO, and other styles

10

Little, Vanessa Renée, and Keith Vaughan. "Synthesis and characterization of a series of 1-methyl-4-[2-aryl-1-diazenyl]piperazines and a series of ethyl 4-[2-aryl-1-diazenyl]-1-piperazinecarboxylates." Canadian Journal of Chemistry 82, no. 8 (2004): 1294–303. http://dx.doi.org/10.1139/v04-081.

Full text

Abstract:

1-Methylpiperazine was coupled with a series of diazonium salts to afford the 1-methyl-4-[2-aryl-1-diazenyl]piperazines (2), a new series of triazenes, which have been characterized by 1H and 13C NMR spectroscopy, IR spectroscopy, and elemental analysis. Assignment of the chemical shifts to specific protons and carbons in the piperazine ring was facilitated by comparison with the chemical shifts in the model compounds piperazine and 1-methylpiperazine and by a HETCOR experiment with the p-tolyl derivative (2i). A DEPT experiment with 1-methylpiperazine (6) was necessary to distinguish the meth

APA, Harvard, Vancouver, ISO, and other styles

11

Sharma, Divyanshu, Nitin Kumar, and Devender Pathak. "Synthesis, characterization and biological evaluation of some newer carbazole derivatives." Journal of the Serbian Chemical Society 79, no. 2 (2014): 125–32. http://dx.doi.org/10.2298/jsc130123069s.

Full text

Abstract:

A series of novel 5-((9H-carbazol-9-yl)methyl)-N-((substituted phenyl)(piperazin-1-yl)methyl)-1,3,4-oxadiazol-2-amine (4a-4o) derivatives was synthesized by starting with carbazole which on reaction with ethyl choloroacetate yielded ethyl 2-(9H-carbazole-9-yl)acetate (1), compound (1) on reaction with semicarbazide followed by cyclisation with sulphuric acid gave 5-((9H-carbazole-9-yl)-1,3,4-oxadiazol-2-amine (3) which through Mannich reaction with piperazine and a variety of aromatic aldehydes in the presence of acetic acid yielded the titled compounds (4a-4o). The structures of compounds wer

APA, Harvard, Vancouver, ISO, and other styles

12

Sweidan, Kamal, Hiba Zalloum, Dima A. Sabbah, Ghada Idris, Khadija Abudosh, and Mohammad S. Mubarak. "Synthesis, characterization, and anticancer evaluation of some new N1-(anthraquinon-2-yl) amidrazone derivatives." Canadian Journal of Chemistry 96, no. 12 (2018): 1123–28. http://dx.doi.org/10.1139/cjc-2018-0145.

Full text

Abstract:

A new series of novel N1-anthraquinon-2-yl amidrazones incorporating N-piperazines and related congeners were synthesized via reaction of the hydrazonoyl chloride derived from 2-qaminoanthraquinone with the appropriate piperazine (secondary amine). Structures of the new compounds were confirmed by a panel of spectroscopic methods including IR, NMR, and MS and by elemental analysis. The antitumor activity of the newly prepared compounds was evaluated in vitro against MCF-7 breast cancer, K562 chronic myelogenous leukemia, and dermal fibroblasts cell lines by means of a cell viability assay usin

APA, Harvard, Vancouver, ISO, and other styles

13

Casalone, Enrico, Tiziano Vignolini, Laura Braconi, et al. "Characterization of substituted piperazines able to reverse MDR in Escherichia coli strains overexpressing resistance-nodulation-cell division (RND) efflux pumps." Journal of Antimicrobial Chemotherapy 77, no. 2 (2021): 413–24. http://dx.doi.org/10.1093/jac/dkab388.

Full text

Abstract:

Abstract Background MDR in bacteria is threatening to public health. Overexpression of efflux pumps is an important cause of MDR. The co-administration of antimicrobial drugs and efflux pump inhibitors (EPIs) is a promising approach to address the problem of MDR. Objectives To identify new putative EPIs and to characterize their mechanisms of action. Methods The effects of four selected piperazine derivatives on resistance-nodulation-cell division (RND) pumps was evaluated in Escherichia coli strains overexpressing or not expressing RND pumps by assays aimed at evaluating antibiotic potentiati

APA, Harvard, Vancouver, ISO, and other styles

14

Aesha F SH Abdassalam, Aesha F. SH Abdassalam, Semih Kurban Semih Kurban, and Nahide Gulsah Deniz and Cigdem Sayil Nahide Gulsah Deniz and Cigdem Sayil. "Synthesis and Characterization of New Naphtho- and Tetracyclic Diazaquinone Derivatives." Journal of the chemical society of pakistan 41, no. 5 (2019): 834. http://dx.doi.org/10.52568/000805/jcsp/41.05.2019.

Full text

Abstract:

In this study, new 1,4-naphtho- and 5-nitro-1,4-naphtho derivatives containing N- and N,N-substituted groups which has not been reported yet, have been synthesized from 2,3-dichloronaphthalene-1,4-diones (1,9). Compounds of 2-choloro-3-((2,4,6-triflorophenyl)amino)naphthalene-1,4-dione (3) and 2-chloro-3-((4-florophenyl)amino)naphtalene-1,4-dione (7) were obtained by reactions of 2,3-dichloronaphthalene-1,4-dione 1 with 4-fluoroaniline (6) and 2,4,6-trifloroaniline (2), respectively involving a Michael addition. We reported the cyclization reactions of compounds 1 to benzo[g]pirido[3,2-b]quino

APA, Harvard, Vancouver, ISO, and other styles

15

SARI, Sait, and Mehmet YILMAZ. "Synthesis and characterization of piperazine-substituted dihydrofuran derivatives viaMn(OAc)3 mediated radical cyclizations." TURKISH JOURNAL OF CHEMISTRY 44, no. 5 (2020): 1303–13. http://dx.doi.org/10.3906/kim-2003-23.

Full text

Abstract:

The aim of this study is to synthesize novel piperazine-containing dihydrofuran compounds (3a-n)from radical additions and cyclizations of diacyl and alkyl-acyl piperazine derivatives (1a-h) with 1,3-dicarbonyl compounds (2a-c) mediated by Mn(OAc)3 for the first time. From the reactions of 1a-c with dimedone (2a);1a, 1c, and 1d with acetylacetone (2b); and 1a with ethylacetoacetate(2c) ,the dihydrofuran-piperazine compounds 3a-c, 3d-f, and 3g were obtained in medium to high yields (31%–81%), respectively. In addition, dihydrofuran-piperazine compounds 3h-j and 3k-n were prepared at low to medi

APA, Harvard, Vancouver, ISO, and other styles

16

Mamat, Constantin, Marc Pretze, Matthew Gott, and Martin Köckerling. "Synthesis, dynamic NMR characterization and XRD studies of novel N,N’-substituted piperazines for bioorthogonal labeling." Beilstein Journal of Organic Chemistry 12 (November 21, 2016): 2478–89. http://dx.doi.org/10.3762/bjoc.12.242.

Full text

Abstract:

Novel, functionalized piperazine derivatives were successfully synthesized and fully characterized by 1H/13C/19F NMR, MS, elemental analysis and lipophilicity. All piperazine compounds occur as conformers resulting from the partial amide double bond. Furthermore, a second conformational shape was observed for all nitro derivatives due to the limited change of the piperazine chair conformation. Therefore, two coalescence points were determined and their resulting activation energy barriers were calculated using 1H NMR. To support this result, single crystals of 1-(4-nitrobenzoyl)piperazine (3a,

APA, Harvard, Vancouver, ISO, and other styles

17

Devender, Pathak, Lata Pandey Suman, and Kumar Nitin. "Synthesis, characterization and in vivo anthelmintic activity of some newer piperazine derivatives." Journal of Indian Chemical Society Vol. 89, May 2012 (2012): 683–88. https://doi.org/10.5281/zenodo.5763407.

Full text

Abstract:

Department of Pharmaceutical Chemistry, Rajiv Academy for Pharmacy, Mathura, N.H. #2 Delhi-Mathura Bye-pass, P.O. Chhatikara, Mathura-281 001, Uttar Pradesh, India <em>E-mail</em> : dev_15@rediffmail.com <em>Manuscript received 24 May 2011, revised 30 August 2011, accepted 07 September 2011</em> Substituted primary aromatic amines on diazotization gives diazonium salt which on reaction with various piperazine derivatives get converted into diazotized product 3a-e, 4a-e and Sb-c. The structures of the newly synthesized piperazine derivatives were accomplished through IR, <sup>1</sup>H NMR and m

APA, Harvard, Vancouver, ISO, and other styles

18

Berezuk, Márcio E., Rafael B. Samulewski, Nakédia M. F. Carvalho, Andrea Paesano Jr., Pedro A. Arroyo, and Lúcio Cardozo-Filho. "Mononuclear iron(III) piperazine-derived complexes and application in the oxidation of cyclohexane." Kataliz v promyshlennosti 21, no. 3 (2021): 183. http://dx.doi.org/10.18412/1816-0387-2021-3-183.

Full text

Abstract:

Oxygenated products from selective hydrocarbon oxidation have high commercial value as industrial feedstocks. One of the most important industrial processes is the cyclohexane oxidation to produce cyclohexanol and cyclohexanone. These organic substances have special importance in the Nylon manufacture as well as building blocks for a variety of commercially useful products. In this work we present the synthesis and characterization of a new mononuclear piperazine-derived series of iron(III) complexes and their catalytic activity towards cyclohexane oxidation essays. All complexes present octah

APA, Harvard, Vancouver, ISO, and other styles

19

Samanta, Subhas, Harris I. Qureshi, and G. Andrew Woolley. "A bisazobenzene crosslinker that isomerizes with visible light." Beilstein Journal of Organic Chemistry 8 (December 14, 2012): 2184–90. http://dx.doi.org/10.3762/bjoc.8.246.

Full text

Abstract:

Background: Large conformational and functional changes of azobenzene-modified biomolecules require longer azobenzene derivatives that undergo large end-to-end distance changes upon photoisomerization. In addition, isomerization that occurs with visible rather than UV irradiation is preferred for biological applications. Results: We report the synthesis and characterization of a new crosslinker in which a central piperazine unit links two azobenzene chromophores. Molecular modeling indicates that this crosslinker can undergo a large change in end-to-end distance upon trans,trans to cis,cis iso

APA, Harvard, Vancouver, ISO, and other styles

20

Mancilla, Teresa, Lourdes Canillo, Luis S. Zamudio-Rivera, Hiram I. Beltrán, and Norberto Farán. "SYNTHESIS AND CHARACTERIZATION OF PIPERAZINE-2,6-DIONES." Organic Preparations and Procedures International 34, no. 1 (2002): 87–94. http://dx.doi.org/10.1080/00304940209355746.

Full text

APA, Harvard, Vancouver, ISO, and other styles

21

Girimanchanaika, Swamy Savvemala, Dukanya Dukanya, Ananda Swamynayaka, et al. "Investigation of NPB Analogs That Target Phosphorylation of BAD-Ser99 in Human Mammary Carcinoma Cells." International Journal of Molecular Sciences 22, no. 20 (2021): 11002. http://dx.doi.org/10.3390/ijms222011002.

Full text

Abstract:

The design and development of a small molecule named NPB [3-{(4(2,3-dichlorophenyl)piperazin-1-yl}{2-hydroxyphenyl)methyl}-N-cyclopentylbenzamide], which specifically inhibited the phosphorylation of BAD at Ser99 in human carcinoma cells has been previously reported. Herein, the synthesis, characterization, and effect on cancer cell viability of NPB analogs, and the single-crystal X-ray crystallographic studies of an example compound (4r), which was grown via slow-solvent evaporation technique is reported. Screening for loss of viability in mammary carcinoma cells revealed that compounds such

APA, Harvard, Vancouver, ISO, and other styles

22

Ruan, Chang Shun, Yuan Liang Wang, Mao Lan Zhang, and Bing Bing Zhang. "Synthesis, Characterization and Optical Properties of a Novel Piperazine Derivative Microcrystal." Advanced Materials Research 194-196 (February 2011): 708–11. http://dx.doi.org/10.4028/www.scientific.net/amr.194-196.708.

Full text

Abstract:

A novel piperazine derivative (4, 4'-(1, 4-piperazinediyl) bis (4-oxo-2-butenoic acid),PBBA) was successfully synthesized under mild conditions by using piperazine and maleic anhydride as feedstock. Its molecular weight and structure were characterized through High-performance liquid chromatography-electrospray mass spectrometry (HPLC-EMS) and Nuclear magnetic resonance (NMR). Then its especial micrystal was also obtained by recrystallizing through co-precipitation in dimethyl sulfoxide-ethanol system. Scanning electron microscopy (SEM) and optical microscope revealed that the uniform shape mi

APA, Harvard, Vancouver, ISO, and other styles

23

Rezler, Mateusz, Teresa Żołek, Irena Wolska, and Dorota Maciejewska. "Structural aspects of intermolecular interactions in the solid state of 1,4-dibenzylpiperazines bearing nitrile or amidine groups." Acta Crystallographica Section B Structural Science, Crystal Engineering and Materials 70, no. 5 (2014): 820–27. http://dx.doi.org/10.1107/s2052520614013754.

Full text

Abstract:

The crystal structures of the title 1,4-bis(4-cyanobenzyl)piperazine (1) and 1,4-bis(4-amidinobenzyl)piperazine tetrahydrochloride tetrahydrate (2) are reported. Compound (1) crystallizes in the triclinic space group P\bar 1 and compound (2) in the monoclinic space groupP21/n. In both (1) and (2) the asymmetric unit contains one half of the molecule because the central piperazine rings were located across a symmetry center. The packing of both molecules was dominated by hydrogen bonds. The crystal lattice of (1) was formed by weak C—H...N and C—H...π interactions. The crystal structure of (2)

APA, Harvard, Vancouver, ISO, and other styles

24

Q. Abdul-Kadir, Maadh, Nadhum E. AL-Ani, and Shakir M. Alwan. "Synthesis of New Cyclic Amines-Linked Metronidazole Derivatives as Possible Prodrugs." Iraqi Journal of Pharmaceutical Sciences ( P-ISSN: 1683 - 3597 , E-ISSN : 2521 - 3512) 18, no. 2 (2017): 1–7. http://dx.doi.org/10.31351/vol18iss2pp1-7.

Full text

Abstract:

Certain cyclic amine derivatives of metronidazole via acetate spacer were prepared. Cyclic amines used are piperidine and piperazine to improve the physicochemical properties and reduce some of metronidazole side effects. This is believed to be done by modification of its structural features to get prodrugs with improved properties over that of metronidazole. The present work includes esterification of metronidazole with choroacetic acid, N-alkylation of the cyclic amines by the halogenated ester and characterization of their structures by spectral(UV and IR) and elemental(CHN)analysis.The mel

APA, Harvard, Vancouver, ISO, and other styles

25

Bodempudi, Suresh Babu, Ravi Chandra Babu Rupakula, Konda S. Reddy, and Mahesh Reddy Ghanta. "ISOLATION, CHARACTERIZATION AND VALIDATION OF HPLC METHOD FOR QUANTIFICATION OF BIS-[10-(2-METHYL-4H-3-THIA-4,9-DIAZABENZO[F]AZULENE)]-1,4-PIPERAZINE IN AN ANTI-PSYCHOTIC DRUG SUBSTANCE, OLANZAPINE." International Journal of Current Pharmaceutical Research 10, no. 4 (2018): 22. http://dx.doi.org/10.22159/ijcpr.2018v10i4.28454.

Full text

Abstract:

Objective: The main objective of present study was to Isolate, characterize and validate a reverse phase high performance liquid chromatographic method was validated for quantification of bis-[10-(2-methyl-4H-3-thia-4,9-diazabenzo[f]azulene)]-1,4-piperazine in Olanzapine drug substance; it decreases the mental disorders in human body. The method is specific, rapid, precise and accurate for the separation and determination of bis-[10-(2-methyl-4H-3-thia-4,9-diazabenzo[f]azulene)]-1,4-piperazine in Olanzapine drug substance form.Methods: The bis-[10-(2-methyl-4H-3-thia-4,9-diazabenzo[f]azulene)]

APA, Harvard, Vancouver, ISO, and other styles

26

Carbonell, Diógenes J., Rodrigo Montoya, Victoria J. Gelling, Juan Carlos Galván, and Antonia Jiménez-Morales. "Enhancing the Corrosion Protection of AA2024-T3 Alloy by Surface Treatments Based on Piperazine-Modified Hybrid Sol–Gel Films." Metals 10, no. 4 (2020): 539. http://dx.doi.org/10.3390/met10040539.

Full text

Abstract:

The aim of this study was to develop new chrome-free surface pretreatments for AA2024-T3 aluminum alloy. These pretreatments were based on hybrid organic–inorganic sol–gel thin films prepared from mixtures of γ-methacryloxypropyltrimethoxysilane (MAPTMS) and tetramethylorthosilicate (TMOS). Different MAPTMS/TMOS molar ratios were used for optimizing the physical–chemical characteristics of the sol–gel films. The formulation of a set of these sols was modified by incorporating piperazine (1,4-diazacyclohexane) as a corrosion inhibitor. The resulting sol–gel films were characterized by using Fou

APA, Harvard, Vancouver, ISO, and other styles

27

Fjellaksel, Richard, Marc Boomgaren, Rune Sundset, Ira H. Haraldsen, Jørn H. Hansen, and Patrick J. Riss. "Small molecule piperazinyl-benzimidazole antagonists of the gonadotropin-releasing hormone (GnRH) receptor." MedChemComm 8, no. 10 (2017): 1965–69. http://dx.doi.org/10.1039/c7md00320j.

Full text

Abstract:

In this communication, we report the synthesis and characterization of a library of small molecule antagonists of the human gonadotropin releasing hormone receptor based upon the 2-(4-tert-butylphenyl)-4-piperazinyl-benzimidazole scaffold via Cu-catalysed azide alkyne cycloaddition.

APA, Harvard, Vancouver, ISO, and other styles

28

Hunter, Naomi, Reid Tingley, Brad Peori, and Keith Vaughan. "Triazene derivatives of (1,x)-diazacycloalkanes. Part VIII. Synthesis and characterization of a series of 1,4-di[2-aryl-1-diazenyl]-2-methylpiperazines1." Canadian Journal of Chemistry 85, no. 3 (2007): 189–96. http://dx.doi.org/10.1139/v07-013.

Full text

Abstract:

A series of 1,4-di-[2-aryl-1-diazenyl]-2-methylpiperazines (4a–n) have been synthesized by the reaction of 2-methylpiperazine with 2 equiv. of the appropriate diazonium salt. The products have been characterized by IR and NMR spectroscopy, and the molecular composition has been verified by HR-EIMS, with accurate mass measurement of the molecular ion. The presence of a chiral centre at C2 of the piperazine ring in the bistriazene 4 creates a multitude of diastereotopic protons in the methylene groups of the piperazine ring, as evidenced by the complexity of the NMR spectra, which nevertheless c

APA, Harvard, Vancouver, ISO, and other styles

29

Kwok, Chun-Kiu, and Thomas C. W. Mak. "Synthesis and structural characterization of N,N′-diarylpiperazine N,N′-dioxide tetrahydrates (aryl = o-tolyl, p-tolyl, p-chlorophenyl)." Canadian Journal of Chemistry 66, no. 8 (1988): 1836–47. http://dx.doi.org/10.1139/v88-297.

Full text

Abstract:

The synthesis and X-ray structure determination of N,N′-di(o-tolyl)piperazine N,N′-dioxide tetrahydrate, I, N,N′-di(p-tolyl)piperazine N,N′-dioxide tetrahydrate, II, and N,N′-di(p-chlorophenyl)piperazine N,N′-dioxide tetrahydrate, III, are described. Compound I crystallizes in space group [Formula: see text] with a = 7.778(1), b = 7.915(2), c = 8.919(2) Å, α = 106.25(2), β = 99.56(1), γ = 108.80(2)°, and Z = 1. Compound II crystallizes in space group [Formula: see text] with a = 6.558(1), b = 7.134(2), c = 11.610(3) Å; α = 73.23(2), β = 78.08(2), γ = 72.67(2)°, and Z = 1. Compound III crystall

APA, Harvard, Vancouver, ISO, and other styles

30

Hu, Ting-Chia, Ming-Chun Wu, Shih-Sheng Wu, et al. "Synthesis, characterization and reactivity study of aluminum compounds incorporating bi- and tri-dentate pyrrole–piperazine ligands." RSC Advances 6, no. 20 (2016): 16331–39. http://dx.doi.org/10.1039/c6ra01694d.

Full text

Abstract:

A series of Al derivatives are afforded incorporating substituted bi- and tri-dentate pyrrole–piperazine precursors. The reactivity with small organic molecules and the associated mechanistic details are also reported.

APA, Harvard, Vancouver, ISO, and other styles

31

Gajjar, Dhaval G., Rinkesh M. Patel, Hema N. Patel, and Pravinkumar M. Patel. "Designing, characterization, and thermal behavior of triazine-based dendrimers." Journal of Polymer Engineering 35, no. 1 (2015): 41–52. http://dx.doi.org/10.1515/polyeng-2014-0123.

Full text

Abstract:

Abstract Different generations of dendritic architecture with piperazine in core moiety and hydroxyl groups on the periphery were designed by divergent method. 1,4-biz(4,6-trichloro-1,3,5-triazin-2-yl)piperazine was synthesized as a core for dendrimer synthesis. Dendrimer was then grown to G3 from core compound using diethanolamine and cyanuric chloride as branching units. Dendrimer generations were characterized by infrared (IR) spectroscopy [Fourier transform IR (FTIR)], 1H-nuclear magnetic resonance (NMR), 13C-NMR, electrospray ionization-mass spectrometry (ESI-MS), and elemental analysis.

APA, Harvard, Vancouver, ISO, and other styles

32

Yang, Fei, Zhaoyuan Jing, Yingqiu Wang, and Guodong Jiang. "A Novel Type II Photoinitiator with Self-Supplied Hydrogen for Anti-Creep Crosslinking Polyethylene Film." Materials 18, no. 6 (2025): 1313. https://doi.org/10.3390/ma18061313.

Full text

Abstract:

Two macromolecular photoinitiators, bis(4-benzoylphenyl) malonate (BPMD) and bis(4-benzoylphenyl) 3,3’-(piperazine-1,4-diyl)bis(3-oxopropanoate) (DBPMD), were successfully synthesized from 4-hydroxybenzophenone (4-BP), malonyl chloride, and anhydrous piperazine. Structural characterization using Fourier transform infrared spectroscopy (FTIR) and proton nuclear magnetic resonance spectroscopy (1H NMR) confirmed the expected molecular framework. Ultraviolet (UV) absorption spectroscopy revealed that BPMD and DBPMD exhibited enhanced molar extinction coefficients and red-shifted absorption maxima

APA, Harvard, Vancouver, ISO, and other styles

33

Shrivastava, Shobhit, and Dharmendra Ahuja. "Synthesis, Characterization and Antimicrobial Activity of Some Novel Mannich Bases of Indole-2,3-dione." Asian Journal of Chemistry 35, no. 5 (2023): 1183–88. http://dx.doi.org/10.14233/ajchem.2023.27738.

Full text

Abstract:

Indole-2,3-dione (isatin) and its 5-substituted derivatives have been reacted with N2-benzylidenepyridine-2,6-diamine to form Schiff bases and the Mannich bases of these compounds were synthesized by reacting them with some secondary amines in presence of formaldehyde. Their chemical structures have been confirmed by mean of their IR and 1H NMR. Antimicrobial screening of synthesized compounds was done by well diffusion method against 4 pathogenic bacteria and 2 pathogenic fungi. Amongst the tested compounds 3-{[6-(benzylideneamino)pyridin-2-yl]imino}-1- (piperazin-1-ylmethyl)-5-fluoro-indolin

APA, Harvard, Vancouver, ISO, and other styles

34

Li, Xu, Xiaolan Chen, Jinwei Yuan, et al. "Synthesis and Characterization of Phosphoramide Piperazine Analogs of Paeonol." Phosphorus, Sulfur, and Silicon and the Related Elements 190, no. 4 (2015): 404–10. http://dx.doi.org/10.1080/10426507.2014.965822.

Full text

APA, Harvard, Vancouver, ISO, and other styles

35

Smirani, W., C. Ben Nasr, and M. Rzaigui. "Synthesis and Structure Characterization of Piperazine-1,4-diium Triphosphate." Phosphorus, Sulfur, and Silicon and the Related Elements 179, no. 11 (2004): 2195–204. http://dx.doi.org/10.1080/10426500490475003.

Full text

APA, Harvard, Vancouver, ISO, and other styles

36

Li, Han, Le Li, Thu Nguyen, Gary T. Rochelle, and Jian Chen. "Characterization of Piperazine/2-Aminomethylpropanol for Carbon Dioxide Capture." Energy Procedia 37 (2013): 340–52. http://dx.doi.org/10.1016/j.egypro.2013.05.120.

Full text

APA, Harvard, Vancouver, ISO, and other styles

37

Mancilla, Teresa, Lourdes Carrillo, Luis S. Zamudio-Rivera, Hiram I. Beltran, and Norberto Farfan. "ChemInform Abstract: Synthesis and Characterization of Piperazine-2,6-diones." ChemInform 33, no. 25 (2010): no. http://dx.doi.org/10.1002/chin.200225149.

Full text

APA, Harvard, Vancouver, ISO, and other styles

38

Haque, Ashanul, Khalaf M. Alenezi, Ahmed Al-Otaibi, et al. "Synthesis, Characterization, Cytotoxicity, Cellular Imaging, Molecular Docking, and ADMET Studies of Piperazine-Linked 1,8-Naphthalimide-Arylsulfonyl Derivatives." International Journal of Molecular Sciences 25, no. 2 (2024): 1069. http://dx.doi.org/10.3390/ijms25021069.

Full text

Abstract:

To reduce the mortality and morbidity associated with cancer, new cancer theranostics are in high demand and are an emerging area of research. To achieve this goal, we report the synthesis and characterization of piperazine-linked 1,8-naphthalimide-arylsulfonyl derivatives (SA1–SA7). These compounds were synthesized in good yields following a two-step protocol and characterized using multiple analytical techniques. In vitro cytotoxicity and fluorescent cellular imaging of the compounds were assessed against non-cancerous fibroblast (3T3) and breast cancer (4T1) cell lines. Although the former

APA, Harvard, Vancouver, ISO, and other styles

39

Cheng, Feixiang, Jishu Chen, Fan Wang, and Ning Tang. "Preparation, Characterization, and Proton-induced Fluorescence Switching of Two Ru(II) Polypyridyl Complexes containing Different N-Heterocyclic Groups." Zeitschrift für Naturforschung B 67, no. 7 (2012): 657–66. http://dx.doi.org/10.5560/znb.2012-0103.

Full text

Abstract:

Two ligands H2L1 and HL2 containing imidazole rings and piperazine or morpholine units have been prepared by the reaction of 1,10-phenanthroline-5,6-dione with 4,4´- (1,4-piperazinediyl)bisbenzaldehyde and 4-morpholinobenzaldehyde, respectively. The Ru(II) polypyridyl complexes [(bpy)2Ru(H2L1)Ru(bpy)2]4+ and [(bpy)2Ru(HL2)]2+ have been synthesized by the reaction of Ru(bpy)2Cl2·2H2O with ligands H2L1 and HL2, respectively. The pH effects on the UV=Vis absorption and fluorescence spectra of both complexes have been studied. The ground-state and excited-state ionization constants of the acid-bas

APA, Harvard, Vancouver, ISO, and other styles

40

Staszewski, Marek, Anna Stasiak, Tadeusz Karcz, et al. "Design, synthesis, and in vitro and in vivo characterization of 1-{4-[4-(substituted)piperazin-1-yl]butyl}guanidines and their piperidine analogues as histamine H3 receptor antagonists." MedChemComm 10, no. 2 (2019): 234–51. http://dx.doi.org/10.1039/c8md00527c.

Full text

APA, Harvard, Vancouver, ISO, and other styles

41

Li, Hui Duan. "Synthesis, Structure and Characterization of a Novel 3D Zinc Organophosphonate." Advanced Materials Research 936 (June 2014): 915–18. http://dx.doi.org/10.4028/www.scientific.net/amr.936.915.

Full text

Abstract:

A novel zinc organophosphonate was synthesized under solvothermal conditions by using [piperazine-1,4-diyldi (methylene)] bis (phosphonic acid) as a organic ligand. Single-crystal X-ray diffraction analysis reveals that compound 1 crystallized in the triclinic space group P-1 (No. 2). Compound 1 formulated as Zn (O3PCH2NHC4H8NHCH2PO3)·H2O. Compound 1 featured a 3D open-framework. Notably, the structure of compound 1 featured one-dimensional channel in the [00 direction. Water molecules were located in these channels. Further characterizations of compound 1 have been performed, including X-ray

APA, Harvard, Vancouver, ISO, and other styles

42

Carrero, Maria G., James J. Posada, and Marcos A. Sabino. "Intelligent copolymers based on poly (N-isopropylacrylamide) PNIPAm with potential use in biomedical applications. Part i: PNIPAm functionalization with 3-butenoic acid and piperazine." International Journal of Advances in Medical Biotechnology - IJAMB 1, no. 1 (2018): 13. http://dx.doi.org/10.25061/2595-3931/ijamb/2018.v1i1.9.

Full text

Abstract:

The synthesis and characterization of the thermosensitive copolymers based on Poly (N-Isopropylacrylamide) (PNIPAm) and 3-butenoic acid and functionalized with piperazine was carried out. The free radical polymerization of the PNIPA copolymer with 3-butenoic acid was performed under microwave radiation. After obtaining this copolymer, the carboxyl groups present in the copolymer chain were activated with 1-ethyl- (3-3-dimethylaminopropyl) carbodiimide in the presence of N-hydroxysuccinimide, improving its reactivity to incorporate the piperazine through its amino group. The characterization co

APA, Harvard, Vancouver, ISO, and other styles

43

Xu, Yanping, and Zhe Lu. "Characterization of Inward-Rectifier K+Channel Inhibition by Antiarrhythmic Piperazine†." Biochemistry 43, no. 49 (2004): 15577–83. http://dx.doi.org/10.1021/bi0483099.

Full text

APA, Harvard, Vancouver, ISO, and other styles

44

Cumming, Jared, Suresh Babu, Ying Huang, et al. "Piperazine sulfonamide BACE1 inhibitors: Design, synthesis, and in vivo characterization." Bioorganic & Medicinal Chemistry Letters 20, no. 9 (2010): 2837–42. http://dx.doi.org/10.1016/j.bmcl.2010.03.050.

Full text

APA, Harvard, Vancouver, ISO, and other styles

45

Al-Qtaitat, Malath A., Haythem A. Saadeh, Amal G. Al-Bakri, et al. "Synthesis, characterization, and biological activity of novel metronidazole-piperazine amides." Monatshefte für Chemie - Chemical Monthly 146, no. 4 (2014): 705–12. http://dx.doi.org/10.1007/s00706-014-1352-0.

Full text

APA, Harvard, Vancouver, ISO, and other styles

46

Chandrasekhar, T., L. Vinay Kumar, P. Jagan Naik, A. Babul Reddy, and G. Narayana Swamy. "ChemInform Abstract: Synthesis and Characterization of New Piperazine Fused Triazoles." ChemInform 46, no. 23 (2015): no. http://dx.doi.org/10.1002/chin.201523197.

Full text

APA, Harvard, Vancouver, ISO, and other styles

47

Muñoz-Osses, Michelle, Fernando Godoy, Angélica Fierro, Alejandra Gómez та Nils Metzler-Nolte. "New organometallic imines of rhenium(i) as potential ligands of GSK-3β: synthesis, characterization and biological studies". Dalton Transactions 47, № 4 (2018): 1233–42. http://dx.doi.org/10.1039/c7dt04344a.

Full text

APA, Harvard, Vancouver, ISO, and other styles

48

Kossakowski, Jerzy, Elżbieta Hejchman та Irena Wolska. "Synthesis and Structural Characterization of Aminoalkanol Derivatives of 2,3-Dihydro-2,2-dimethyl-7-benzofuranol with an Expected β-Adrenolytic and / or Anxiolytic Activity". Zeitschrift für Naturforschung B 57, № 3 (2002): 285–94. http://dx.doi.org/10.1515/znb-2002-0305.

Full text

Abstract:

AbstractA series of fifteen new N-substituted derivatives of 2,3-dihydro-2,2-dimethyl-7-benzofuranol have been prepared and studied by IR and 1H NMR spectroscopy. In addition the crystal structures of 7-[3-[4-(4-fluorophenyl)-1-piperazinyl]propoxy]-2,3-dihydro-2,2-dimethylbenzofuran (16), 7-[3-(4-phenyl-1-piperazinyl)propoxy]-2,3-dihydro-2,2-dimethylbenzofuran (18) and 7-[3-(4-benzyl-1-piperazinyl)propoxy]-2,3-dihydro-2,2-dimethylbenzofuran (20) have been solved by X-ray structure analysis of single crystals. The crystals of two of them (16 and 18) are isostructural and there are only small di

APA, Harvard, Vancouver, ISO, and other styles

49

R., Parasuraman *. Vardhineedi Shirisha K. Pavan Kumar N. Namitha M. Keerthana N. Prashanth Reddy. "Synthesis, Characterization And Anti-Bacterial Activity Of Novel Chalcone Derivatives." International Journal in Pharmaceutical Sciences 2, no. 5 (2024): 1883–91. https://doi.org/10.5281/zenodo.11403805.

Full text

Abstract:

Chalcones have been a class of important synthetic anti-microbial agents and effectively used in clinic for infectious diseases. In this study, chalcone derivatives of 5(1-Ethyl piperazine 4-yl) 2-Acetyl thiophene and p-Substituted Benzaldehyde have been synthesized          and screened for antibacterial activities. All the synthesized compounds (TP1-TP4) were characterized by spectral studies and evaluated for in-vitro anti-bacterial activity. All the synthesized compounds (TP1-TP4) showed the antibacterial activity against strains of Bacillus sub

APA, Harvard, Vancouver, ISO, and other styles

50

Rueda, Juan Carlos, and Hellyn Gudiel Honoresa. "2-oxazoline telechelic polymers: Synthesis and characterization." Journal of Polymer Science and Engineering 8, no. 1 (2025): 11787. https://doi.org/10.24294/jpse11787.

Full text

Abstract:

New telechelic polymers functionalized with terminal ethyl xanthate or vinyl groups were synthesized via cationic ring-opening polymerization (CROP). The polymerization of 2-ethyl-2-oxazoline (Etoxa) and 2-methoxycarbonylethyl-2-oxazoline (Esteroxa) was initiated by 1,4-trans-dibromobutene in acetonitrile at 78 ℃, with termination using either potassium ethyl xanthate or 4-vinylbenzyl-piperazine. Structural characterization by 1H and 13C NMR and FTIR spectroscopy confirmed the telechelic architecture. 1H NMR analysis revealed degrees of polymerization (DP) of 24–29 for ethyl xanthate-terminate

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!