Relevant bibliographies by topics / Charantin / Journal articles

To see the other types of publications on this topic, follow the link: Charantin.

Journal articles on the topic 'Charantin'

Author: Grafiati

Published: 5 June 2025

Last updated: 15 July 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 journal articles for your research on the topic 'Charantin.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

Afita, Mella, Nani Wijayanti Dyah Nurrahman, and Giftania Wardani Sudjarwo. "AKTIVITAS ANTIDIABETES DARI BERBAGAI Genus Momordica SECARA IN VIVO." JOURNAL OF PHARMACY SCIENCE AND TECHNOLOGY 3, no. 2 (2023): 217–26. http://dx.doi.org/10.30649/pst.v3i2.43.

Full text

Abstract:

Diabetes melitus (DM) adalah penyakit kronis berupa gangguan metabolik dimana kadar glukosa darah di atas batas normal. Salah satu contoh tanaman yang dapat menurunkan kadar glukosa darah yaitu dari Genus Momordica, terdapat 3 tanaman dari Genus Momordica yaitu Momordica charantia, Momordica cymbalaria dan Momordica dioica yang mempunyai kandungan senyawa yang paling banyak ditemukan yaitu saponin dan charantin. Pada penelitian ini bertujuan untuk mengkaji adanya aktivitas antidiabetes dari berbagai Genus Momordica secara in vivo. Kandungan Saponin pada Genus Momordica bekerja dengan cara menghambat kerja enzim α-glukosidase yaitu enzim yang ada didalam usus yang berfungsi untuk mengubah karbohidrat menjadi glukosa. Kandungan kedua adalah charantin. Charantin bekerja engan menstimulasi sel beta kelenjar pankreas untuk memproduksi insulin lebih banyak dan meningkatkan cadangan glikogen di hati. Dari literatur review yang dilakukandapat disimpulkan bahwa tanaman dari Genus Momordica yaitu Momordica charantia, Momordica cymbalaria, dan Momordica dioica mengandung senyawa saponin dan charantin yang mempunyai potensi sebagai antidiabetes atau menurunkan kadar glukosa darah secara in vivo.

APA, Harvard, Vancouver, ISO, and other styles

Zaini, Ahmad Syahmi, Noor Aiysah Aris, Nicky Rahmana Putra, et al. "Comparison of charantin extract from Momordica Charantia using modified supercritical carbon dioxide and soxhlet extraction method." Malaysian Journal of Fundamental and Applied Sciences 14, no. 4 (2018): 462–66. http://dx.doi.org/10.11113/mjfas.v14n4.1092.

Full text

Abstract:

Charantin extract from Momordica Charantia fruits for anti-diabetic compound was proposed via Supercritical Fluid Extraction using carbon dioxide (SC-CO2) as solvent. This method is a promising alternative technique to a conventional Soxhlet and shaking water bath extraction method. Experiments were conducted to analyze the charantin i) with and without modifier (ethanol), ii) Soxhlet extraction with four types of solvent (distilled water, ethanol, dichloromethane, and petroleum ether) and iii) shaking water bath with distilled water as a solvent. A purification step was conducted post extraction to remove intrusive components such as chlorophylls and sugar from analyte in order to quantify charantin extract using high performance liquid chromatography (HPLC). The results show that, in 2.5 hours SC-CO2 with ethanol as modifier gives highest charantin yield with 0.7817 mg charantin per gram sample. In contrast, shaking water bath gives the highest charantin yield for conventional method with 0.712 mg charantin per gram sample during 6 hours of extraction. The result shows that by using SC-CO2 modified with ethanol can be a promising “green” extraction than conventional method.

APA, Harvard, Vancouver, ISO, and other styles

Ahamad, Javed, Showkat R Mir, and Saima Amin. "ANTIHYPERGLYCEMIC ACTIVITY OF CHARANTIN-RICH EXTRACT FROMTHE FRUITS OF Momordica charantia Linn. IN in vitro AND in vivo STUDIES." Applied Biological Research 26, no. 4 (2024): 521–27. https://doi.org/10.48165/abr.2024.26.01.60.

Full text

Abstract:

Momordica charantia Linn. (Bitter gourd or Karela) fruits are one of the common vegetable consumed in India; traditionally used for the management of blood glucose levels (BGL) in diabetes. The present study aimed to evaluate the antihyperglycemic potential of charantin-rich extract from the fruits of bitter gourd in in-vitro enzyme inhibition assay (α-amylase and α-glucosidase) and in-vivo using carbohydrate-challenged normal and STZ-induced diabetic rats. The bitter gourd fruits were extracted using an ultrasonicator and the extract was assayed for the charantin content using the HPTLC method. The standardized extract of M. charantia (SMC) contained 0.34±0.15% w/w charantin. The charantin-rich extracts of M. charantia showed concentration-dependent inhibition of α-amylase and α-glucosidase enzymes with IC50 values 1.41±0.17 and 2.29 ± 1.84 mg/mL, respectively. In starch and sucrose challenged normal rats, pre-treatment with SMC (200 mg/kg, b.w.) produced 13.04% and 16.32% reduction in peak BGL compared to the negative control. In starch and sucrose-challenged diabetic rats (induced by a single intraperitoneal injection of streptozotocin, 50 mg/kg, b.w.), pre-treatment with SM at a dose of 200 mg/kg, b.w. produced 7.44% and 8.32% reduction in peak BGL when compared with toxic control. The study results provided scientific evidence for the fact that bitter gourd fruits are effective in the management of BGL in diabetes which can be mainly attributed to charantin.

APA, Harvard, Vancouver, ISO, and other styles

Jadhav, Shailaja, and Adhikarao Yadav. "Supercritical CO2 Extraction, Quantification and Pharmacological Screening of Steroidal Saponins from Fruits of Momordica charantia L." INTERNATIONAL JOURNAL OF PHARMACEUTICAL QUALITY ASSURANCE 14, no. 03 (2023): 563–72. http://dx.doi.org/10.25258/ijpqa.14.3.18.

Full text

Abstract:

Momordica charantia L. (MC), a Cucurbitaceae family member, is the most recognized plant for its hypoglycemic activity. Charantin, a steroidal saponin, is the most studied potent phytochemical in MC for diabetes. This research paper aims at the extraction, quantification and pharmacological screening of charantin, from fruits of MC. Extraction was performed by using traditional soxhlet extraction and modified supercritical fluid extraction (SFE) techniques, and compared the results of both techniques in terms of percent extract yield, quantity of charantin and in-vitro antidiabetic activity of both extracts. (Soxhlet extract and SC-CO2 extract). Further, quantitative estimation of charantin in both extracts was done by HPLC-UV method and it was validated as per the ICH guidelines. When compared to soxhlet extract, the SC-CO2 extract displayed high antihyperglycemic activity by blocking α-amylase and α-glucosidase enzymes. Study also indicates that SC-CO2 extract had higher antioxidant activity (0.25 mg/mL) than soxhlet extract (0.33 mg/mL), signifying the SFE technique’s efficiency over the traditional soxhlet extraction method. In-vitro antidiabetic study indicated that the biomolecule charantin extracted from fruits of MC possess potent antidiabetic and high antioxidant activities and, therefore, hold potential for manufacturing innovative natural remedies to treat diabetes and its complications with no side effects.

APA, Harvard, Vancouver, ISO, and other styles

Nuchtavorn, Nantana, Jiraporn Leanpolchareanchai, Satsawat Visansirikul, and Somnuk Bunsupa. "Optimization of Magnetic and Paper-Based Molecularly Imprinted Polymers for Selective Extraction of Charantin in Momordica charantia." International Journal of Molecular Sciences 24, no. 9 (2023): 7870. http://dx.doi.org/10.3390/ijms24097870.

Full text

Abstract:

Charantin is a mixture of β-sitosterol and stigmastadienol glucosides, which effectively lowers high blood glucose. Novel molecularly imprinted polymers coated magnetic nanoparticles (Fe3O4@MIPs) and filter paper (paper@MIPs) were synthesized by sol-gel polymerization to selectively extract charantin. β-sitosterol glucoside was selected as a template for imprinting a specific recognition owing to its larger molecular surface area than that of 5,25-stigmastadienol glucoside. Factorial designs were used to examine the effects of the types of porogenic solvents and cross-linkers on the extraction efficiency and imprinting factor before investigating other factors (for example, amounts of template and coated MIPs, and types of substrates for MIP immobilization). Compared to traditional liquid–liquid extraction, the optimal Fe3O4@MIP-based dispersive micro-solid phase extraction and paper@MIP extraction provided excellent extraction efficiency (87.5 ± 2.1% and 85.0 ± 2.9%, respectively) and selectivity. Charantin was well separated, and a new unidentified sterol glucoside was observed using the developed high-performance liquid chromatography with diode-array detection (Rs ≥ 2.0, n > 16,400). The developed methods were successfully utilized to extract and quantify charantin from M. charantia fruit powder and herbal products. Moreover, these methods are rapid (<10 min), inexpensive, simple, reproducible, and environmentally friendly.

APA, Harvard, Vancouver, ISO, and other styles

Rahayu, Sri, and Nor Anisah. "PENGARUH VARIASI KONSENTRASI AMPROTAB SEBAGAI DESINTEGRANT TERHADAP SIFAT FISIK TABLET EKSTRAK BUAH PARE (MOMORDICA CHARANTIA L.)." Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan 6, no. 1 (2021): 39–48. http://dx.doi.org/10.36387/jiis.v6i1.572.

Full text

Abstract:

Bitter melon (Momordica charantia L.) is a type of medicinal plant that is widely used by the public. Charantin is one of the nutritious compounds contained in bitter melon. Charantin compounds can be used to reduce glucose levels in the blood so that it is widely used as a diabetes medicine. The research aims to determine the effect of variations in the concentration of amprotab as a desintegrant on the physical properties of Pare (Momordica charantia L.) extract tablets has been conducted. Viscous extract was made by maceration method by using ethanol 96%. Tablets made by wet granulation method in two different desintegrant concentration of 9,6% and 18%. Dried granule tested with flowability, angle of repose and indeks of compressibility. Tablet evaluation includes uniformity of weight test, friability test, hardness test and disintegration test. The results showed that formula with amprotab as desintegration at 9,6 % concentration was able to produce tablets that met the requirements. Variation in concentration of desintegrant material take effect on the uniformity of weight, hardness friability and disintegration time.

APA, Harvard, Vancouver, ISO, and other styles

Naik, Archana, Chhaya Gadgoli, Nikita Patil, and Ruchira Salunkhe. "Simultaneous Estimation for Diosgenin, Charantin and Hydroxychalcone from Herbal Antidiabetic Formulation using Validated HPTLC Method." INTERNATIONAL JOURNAL OF PHARMACEUTICAL QUALITY ASSURANCE 14, no. 03 (2023): 612–17. http://dx.doi.org/10.25258/ijpqa.14.3.26.

Full text

Abstract:

Most antidiabetic polyherbal preparations contain Trigonella foenum-graecum, Momordica charantia and Cinnamomum zeylanicum as active components. Although all ingredients are popular as antidiabetic agents, but the analytical method is not available for simultaneous estimation of marker compounds from herbal formulations due to several challenges. Hence, the HPTLC method was developed for simultaneous estimation of three active phytoconstituents viz. diosgenin, charantin and hydroxychalcone in polyherbal formulation. The stationary phase of the optimized HPTLC method is silica gel 60 GF254 and the mobile phase is chloroform: glacial acetic acid: methanol: water (4:3:2:1v/v). The Rf value of phytoconstituents charantin, diosgenin, and hydroxychalcone was found to be 0.72, 0.61 and 0.30 at detection wavelength 342 nm. According to ICH criteria, the analytical method validation was performed. All three markers showed linear and proportional responses in the 400 to 1400 ng/band range, which confirmed the markers’ linearity. Precision measurements were made at the intraday and interday levels, and the results were satisfactory and in line with the specifications. Accuracy was determined by the recovery method and %recovery was found to be in the range of 85.20 to 97.19. The validated HPTLC method was utilized to analyze the marketed Quanto Diab Forte capsule formulation containing charantin, diosgenin, and hydroxychalcone. The proposed validated analytical method was found to be simple, precise and accurate.

APA, Harvard, Vancouver, ISO, and other styles

Cuong, Do Manh, Ramaraj Sathasivam, Chang Ha Park, et al. "Analysis of triterpenoids, carotenoids, and phenylpropanoids in the flowers, leaves, roots, and stems of white bitter melon (Cucurbitaceae, Momordica charantia)." Tropical Journal of Pharmaceutical Research 20, no. 1 (2021): 155–60. http://dx.doi.org/10.4314/tjpr.v20i1.22.

Full text

Abstract:

Purpose: To evaluate the contents of carotenoids, triterpenoids, and phenylpropanoids in different parts of white bitter melon.Methods: We evaluated the accumulation of 2 triterpenoids, 10 carotenoids, and 11 phenylpropanoids in different parts of white bitter melon, including fruits at four different developmental stages using HPLC.Results: Charantin, lutein, and rutin were the main triterpenoids, carotenoids, and phenylpropanoids, respectively. The accumulation of triterpenoids (momordicine and charantin), carotenoids (antheraxanthin, lutein, violaxanthin, α-carotene, and β-carotene), and phenylpropanoids (caffeic acid, chlorogenic acid, epicatechin, gallic acid, p-coumaric acid, rutin, and trans-cinnamic acid) was high inthe leaves and/or flowers, which are exposed to direct sunlight, but low in the roots.Conclusion: Most of the analyzed components were accumulated at high levels in the leaves and/or flowers. These results will help exploit the compounds in various parts of white bitter melon that are beneficial for human health. Keywords: Momordica charantia, Bitter melon, Triterpenoid, Carotenoid, Phenylpropanoid

APA, Harvard, Vancouver, ISO, and other styles

Sharma, Shweta, and Viveka Katoch. "Anti-Diabetic Properties of Bitter Gourd." International Journal of Economic Plants 7, no. 1 (2020): 021–24. http://dx.doi.org/10.23910/2/2020.0331.

Full text

Abstract:

Bitter gourd (Momordica charantia L.) is a fruit that traditionally believe to have benefits on health. It is a widely used traditional remedy for the treatment of diabetes. Bitter gourd is suggested for hyperglycemia treatment due to its ability to reduce glucose levels in the body. Some of the bioactive compounds present in it possess anti diabetic effects. It contains phytochemicals with anti-diabetic properties such as charantin, p-insulin and vicine. Hypoglycemic effects of bitter gourd have been shown in clinical studies. This review will focus on the hyperglycemic properties of bitter gourd.

APA, Harvard, Vancouver, ISO, and other styles

Kusniawati, Mega Ayu. "Sistematik Review Aktivitas Buah Pare (Momordica charantia L.) Terhadap Target Molekuler Antidiabetes." Jurnal Farmasi Indonesia 18, no. 2 (2021): 141–51. http://dx.doi.org/10.31001/jfi.v18i2.974.

Full text

Abstract:

Diabetes melitus (DM) adalah penyakit kronis yang terjadi baik ketika pankreas tidak menghasilkan cukup insulin, atau ketika tubuh tidak dapat secara efektif menggunakan insulin yang dihasilkannya. Tujuan mengetahui aktivitas buah pare terhadap target molekuler antidiabetes secara literature review. Analisis dan tinjauan pencarian web sistematis dilakukan pada literatur penelitian yang berkaitan dengan buah pare digunakan untuk aktivitas DPP4, PTP1B, α-glukosidase, dan peningkatkan kadar GLUT4. Data dikumpulkan dari beberapa jurnal dengan kriteria inklusi. Data diekstraksi dan data sintesis. Studi literatur review senyawa charantin, cucurbitacin, dan momordicoside D secara bersamaan mengaktivasi reseptor TGR5 dan GLP1 untuk menghambat DPP4, senyawa cucurbitane 25-O-methylkaraviagein D dikaitkan dengan keberadaan –OH memiliki aktivitas penghambatan terhadap enzim PTP1B, senyawa 3β, 7β, 25-trihydroxycucurbita-5,23(E)-dien-19-al, charantal, charantoside XI, dan 25ξ- isopropenylchole-5, 6-ene-3-O- D-glukopiranosida diprediksi memiliki afinitas mengikat sisi aktif protein sehingga menghambat α-glukosidase, dan senyawa charantin, vicine, polypeptide-p, 5-,19-epoxy-3-, 25-dihydroxycucurbita-6,23 (E) -diene dan 3- 7-, 25-trihydroxycucurbita-5,23 (E)-dien-19-al. dapat meningkatkan jumlah GLUT4 pada permukaan sel.

APA, Harvard, Vancouver, ISO, and other styles

Ahamad, Javed, Showkat R. Mir, and Saima Amin. "ANTIHYPERGLYCEMIC ACTIVITY OF CHARANTIN ISOLATED FROM FRUITS OF MOMORDICA CHARANTIA LINN." International Research Journal Of Pharmacy 10, no. 1 (2019): 61–64. http://dx.doi.org/10.7897/2230-8407.100111.

Full text

APA, Harvard, Vancouver, ISO, and other styles

Afifah, Andi Retno, Sri Wahyu, Sri Wahyuni Gayatri, Indah Lestari Daeng Kanang, and Rezky Putri Indarwati Abdullah. "Pengaruh Pemberian Ekstrak Buah Pare Terhadap Penurunan Kadar Glukosa Darah Pada Mencit (Mus musculus)." Indonesian Journal of Health 1, no. 03 (2021): 163–69. http://dx.doi.org/10.33368/inajoh.v1i03.66.

Full text

Abstract:

Diabetes melitus (DM) mengacu pada sindrom hiperglikemia akibat berbagai penyebab. Dewasa ini, banyak masyarakat yang mengkonsumi buah pare sebagai obat diabetes. Karena menurut pemikiran mereka, rasa pahit nya dapat menetralisir kadar gula dalam darah. Momordica charantia (Buah Pare) adalah tanaman yang digunakan sebagai sayuran dan obat tradisional dengan aktivitas buah hipoglikemik. Momordica charantia (Buah Pare) mengandung senyawa seperti insulin yang disebut charantin yang memiliki sifat anti diabetes dan membantu mengurangi kadar gula darah. Penelitian ini bertujuan mengetahui pengaruh pemberian ekstrak buah pare (Momordica charantia) terhadap penurunan kadar glukosa darah pada mencit (Mus musculus). Jenis penelitian ini menggunakan Literature Review dengan desain Narrative Review. Ekstrak buah pare (Momordica charantia) dapat menurunkan kadar glukosa darah pada mencit (Mus musculus) diabetes dengan konsentrasi 100 mg/kgBB, 250 mg/kgBB dan 400 mg/kgBB. Ekstrak buah pare (Momordica charantia) dengan konsentrasi 400 mg/KgBB dapat menurunkan glukosa darah yang hampir setara dengan pemberian metformin pada mencit (Mus musculus) yang diabetes. Ekstrak buah pare (Momordica charantia) dapat menurunkan kadar glukosa darah pada mencit (Mus musculus) diabetes. Namun lebih efektif pada dosis 400 mg/Kg.

APA, Harvard, Vancouver, ISO, and other styles

Andi Retno Afifah, Sri Wahyu, Sri Wahyuni Gayatri, et al. "Pengaruh Pemberian Ekstrak Buah Pare (Momordica Charantia) Terhadap Penurunan Kadar Glukosa Darah Pada Mencit (Mus Musculus)." Fakumi Medical Journal: Jurnal Mahasiswa Kedokteran 2, no. 3 (2022): 224–30. http://dx.doi.org/10.33096/fmj.v2i3.158.

Full text

Abstract:

Diabetes melitus (DM) mengacu pada sindrom hiperglikemia akibat berbagai penyebab. Dewasa ini, banyak masyarakat yang mengkonsumi buah pare sebagai obat diabetes. Karena menurut pemikiran mereka, rasa pahitnya dapat menetralisir kadar gula dalam darah. Momordica charantia (Buah Pare) adalah tanaman yang digunakan sebagai sayuran dan obat tradisional dengan aktivitas buah hipoglikemik. Momordica charantia (Buah Pare) mengandung senyawa seperti insulin yang disebut charantin yang memiliki sifat anti diabetes dan membantu mengurangi kadar gula darah. Penelitian ini bertujuan mengetahui pengaruh pemberian ekstrak buah pare (Momordica charantia) terhadap penurunan kadar glukosa darah pada mencit (Mus musculus). Jenis penelitian ini menggunakan Literature Review dengan desain Narrative Review. Ekstrak buah pare (Momordica charantia) dapat menurunkan kadar glukosa darah pada mencit (Mus musculus) diabetes dengan konsentrasi 100 mg/kgBB, 250 mg/kgBB dan 400 mg/kgBB. Ekstrak buah pare (Momordica charantia) dengan konsentrasi 400 mg/KgBB dapat menurunkan glukosa darah yang hampir setara dengan pemberian metformin pada mencit (Mus musculus) yang diabetes. Ekstrak buah pare (Momordica charantia) dapat menurunkan kadar glukosa darah pada mencit (Mus musculus) diabetes. Namun lebih efektif pada dosis 400 mg/KgBB

APA, Harvard, Vancouver, ISO, and other styles

Cristiannanda, Daniel, Dinda Mutiara Hati, Gina Mutia Hafid, et al. "Molecular docking of triterpene glycoside compounds (cucurbitane, charantin and momordicin) in bitter gourd (Momordica charantia L.) fruit as anti-diabetes mellitus type 2." Pharmacy Reports 2, no. 3 (2024): 68. https://doi.org/10.51511/pr.68.

Full text

Abstract:

Diabetes mellitus is a chronic metabolic disorder characterized by elevated blood glucose levels due to impaired insulin secretion, insulin resistance, or both. Type 2 diabetes mellitus (T2DM) accounts for approximately 90% of all diabetes cases and remains a significant global health challenge. Current pharmacological treatments often have limited efficacy and adverse side effects, necessitating the exploration of safer, more effective antidiabetic agents. Momordica charantia (bitter melon) is a medicinal plant known for its hypoglycemic properties, attributed to bioactive compounds such as cucurbitane-type triterpenoid glycosides, charantin, and momordicin. This study evaluated the potential of cucurbitane, charantin, and momordicin as antidiabetic agents for T2DM using molecular docking simulations. The crystal structure of aldose reductase (PDB ID 2HV5) was obtained from the Protein Data Bank, and AutoDock Tools 1.5.7 was used for docking studies. The binding affinities and interaction patterns of the test compounds were compared with zopolrestat, a standard ligand. Cucurbitane exhibited the lowest binding free energy (-11.70 kcal/mol), indicating the strongest interaction with the 2HV5 protein. All compounds demonstrated similarities in their interactions with key amino acid residues, suggesting comparable biological activity. These findings highlight cucurbitane’s potential as a lead compound for developing more effective antidiabetic therapies for T2DM.

APA, Harvard, Vancouver, ISO, and other styles

Rahma, Jaini, Ira Munirah, Latifah Mukhlisatunnafsi, M. Diaz Nur Syamsu, and Herpan Syafii Harahap. "POTENSI Momordica charantia SEBAGAI ANTIDIABETIK : STUDI LITERATUR." Jurnal Medika Malahayati 8, no. 1 (2024): 60–69. http://dx.doi.org/10.33024/jmm.v8i1.12816.

Full text

Abstract:

Abstrak: Potensi Momordica Charantia Sebagai Antidiabetik : Studi Literatur. Momordica charantia (MC) atau yang dikenal dengan buah pare merupakan tanaman tradisional yang memiliki senyawa aktif seperti charantin polypeptide-P insulin untuk menurunkan kadar glukosa. Diabetes melitus adalah penyakit yang tidak menular dengan angka prevalensi penderita diabetes pada usia 20-79 tahun sekitar 11,3% yang menempatkannya di posisi ke-3 dengan wilayah arab-afrika dan pasifik barat sebagai posisi ke-1 dan ke-2. Dan Indonesia menjadi satu-satunya negara Asia Tenggara yang masuk kedalam 10 besar negara yang diproyeksikan IDF dengan angka diabetes ke-7 tertinggi. Metode yang digunakan yaitu dengan cara pencarian secara komprehensif pada 2 database (Pubmed dan Google Scholar) dari tahun 2015-2023, serta menggunakan kata kunci “Momordica charantia”, “Antidiabetes”, “Diabetes mellitus”. Data yang ditelaah dari setiap artikel penelitian yaitu meliputi identitas artikel, definisi, senyawa aktif yang berperan, patofisiologi, mekanisme kerja senyawa serta hasil dan kesimpulan penelitian. Hasil yang didapatkan menunjukkan bahwa Momordica charantia berguna untuk menurunkan glukosa darah. Ekstrak air yang terkandung dalam pare dapat mempengaruhi penggunaan glukosa dengan mengaktifkan Adenosine-monophosphate-activated protein kinase (AMPK) di jaringan otot.

APA, Harvard, Vancouver, ISO, and other styles

Lee, Shi Yan, Won Fen Wong, Jiyang Dong, and Kian-Kai Cheng. "Momordica charantia Suppresses Inflammation and Glycolysis in Lipopolysaccharide-Activated RAW264.7 Macrophages." Molecules 25, no. 17 (2020): 3783. http://dx.doi.org/10.3390/molecules25173783.

Full text

Abstract:

Macrophage activation is a key event that triggers inflammatory response. The activation is accompanied by metabolic shift such as upregulated glucose metabolism. There are accumulating evidences showing the anti-inflammatory activity of Momordica charantia. However, the effects of M. charantia on inflammatory response and glucose metabolism in activated macrophages have not been fully established. The present study aimed to examine the effect of M. charantia in modulating lipopolysaccharide (LPS)-induced inflammation and perturbed glucose metabolism in RAW264.7 murine macrophages. The results showed that LPS-induced NF-κB (p65) nuclear translocation was inhibited by M. charantia treatment. In addition, M. charantia was found to reduce the expression of inflammatory genes including IL6, TNF-α, IL1β, COX2, iNOS, and IL10 in LPS-treated macrophages. Furthermore, the data showed that M. charantia reduced the expression of GLUT1 and HK2 genes and lactate production (−28%), resulting in suppression of glycolysis. Notably, its effect on GLUT1 gene expression was found to be independent of LPS-induced inflammation. A further experiment also indicated that the bioactivities of M. charantia may be attributed to its key bioactive compound, charantin. Taken together, the study provided supporting evidences showing the potential of M. charantia for the treatment of inflammatory disorders.

APA, Harvard, Vancouver, ISO, and other styles

Lee, Hee Ju, Ji-Hye Moon, Woo-Moon Lee, et al. "Charantin Contents and Fruit Characteristics of Bitter Gourd (Momordica charantia L.) Accessions." Journal of Bio-Environment Control 21, no. 4 (2012): 379–84. http://dx.doi.org/10.12791/ksbec.2012.21.4.379.

Full text

APA, Harvard, Vancouver, ISO, and other styles

Valyaie, Akram, Majid Azizi, Abdolkarim Kashi, et al. "Evaluation of Growth, Yield, and Biochemical Attributes of Bitter Gourd (Momordica charantia L.) Cultivars under Karaj Conditions in Iran." Plants 10, no. 7 (2021): 1370. http://dx.doi.org/10.3390/plants10071370.

Full text

Abstract:

Vegetative and reproductive characteristics, fruit yield, and biochemical compounds of six bitter melon cultivars (Iranshahr, Mestisa, No. 486, Local Japanese, Isfahan, and Ilocano) were evaluated under Karaj conditions in Iran. The phytochemical properties of the cultivars were evaluated using both shade-dried and freeze-dried samples at three fruit developmental stages (unripe, semi-ripe, and ripe). There were significant differences in the vegetative and reproductive characteristics among cultivars, where cv. No. 486 was superior to most vegetative attributes. The fruit yield of cultivars varied from 2.98–5.22 kg/plant. The number of days to male and female flower appearance ranged from 19.00–25.33 and from 25–33 days, respectively. The leaf charantin content was in the range of 4.83–11.08 μg/g. Fruit charantin content varied with developmental stage, drying method, and cultivar. The highest charantin content (13.84 ± 3.55 µg/g) was observed at the semi-ripe fruit stage, and it was much higher in the freeze-dried samples than the shade-dried samples. Cultivar No. 486 had the highest (15.43 ± 2.4 µg/g) charantin content, whereas the lowest charantin content (8.51 ± 1.15 µg/g) was recorded in cultivar cv. Local Japanese. The highest total phenol content (25.17 ± 2.27 mg GAE/g) was recorded in freeze-dried samples of ripe fruits of cv. No. 486, whereas the lowest phenol content was detected in the shade-dried samples of semi-ripe fruits of Isfahan. cv. Flavonoid content was higher with the shade-drying method, irrespective of cultivar. In conclusion, considering the fruit yield and active biological compounds in the studied cultivars, cv. No. 486 should be grown commercially because of its higher yield and production of other secondary metabolites.

APA, Harvard, Vancouver, ISO, and other styles

Pramesthi, Asri Dwi Endah Dewi, Kafka Navisa Suwarno, Aldo Pratama, Jamiatur Rasyidah, I Wayan Surya Rahadi, and Rima Rasida. "IN SILICO ANALYSIS OF MOMORDICA CHARANTIA L. AS ANTIDIABETIC AGENTS THROUGH ACTIVATION OF HUMAN UDP-GALACTOSE 4-EPIMERASE RECEPTORS." Media Farmasi 20, no. 2 (2024): 201–8. http://dx.doi.org/10.32382/mf.v20i2.1002.

Full text

Abstract:

This study investigates the antidiabetic potential of compounds found in Momordica charantia L., commonly known as bitter melon, through molecular docking and ADME (Absorption, Distribution, Metabolism, and Excretion) analysis. Utilizing in silico methods, several bioactive compounds from bitter melon, such as charantin, vicine, momordenol, momordicilin, and momordicoside, were evaluated for their ability to interact with the human UDP-Galactose 4-Epimerase receptor, a key enzyme involved in glucose metabolism. The docking results indicate that these compounds exhibit strong binding affinities, suggesting their role in glucose regulation. Further ADME analysis revealed that the compounds generally comply with the Lipinski Rule of Five, indicating favorable drug-like properties, though some compounds exhibited potential toxicities requiring further investigation. These findings highlight the potential of Momordica charantia as a source of antidiabetic agents, warranting additional in vivo and clinical studies to confirm their efficacy and safety in managing diabetes mellitus.

APA, Harvard, Vancouver, ISO, and other styles

Sung Goo, Kang, Sumeru Ashari, Nur Basuki, and Arifin Noor Sugiharto. "The Bitter Gourd Momordica charantia L.: Morphological Aspects, Charantin and Vitamin C Contents." IOSR Journal of Agriculture and Veterinary Science 09, no. 10 (2016): 76–81. http://dx.doi.org/10.9790/2380-0910017681.

Full text

APA, Harvard, Vancouver, ISO, and other styles

Guo, Zijun, Guocai Wang, Maoxin Zhang, Guangwen Liang, Qiang Li, and Bing Ling. "Evaluation of Cytotoxic Activity in vitro of Charantin A Extracted from Momordica charantia." Records of Natural Products 12, no. 5 (2018): 416–25. http://dx.doi.org/10.25135/rnp.61.17.12.190.

Full text

APA, Harvard, Vancouver, ISO, and other styles

PITIPANAPONG, J., S. CHITPRASERT, M. GOTO, W. JIRATCHARIYAKUL, M. SASAKI, and A. SHOTIPRUK. "New approach for extraction of charantin from Momordica charantia with pressurized liquid extraction." Separation and Purification Technology 52, no. 3 (2007): 416–22. http://dx.doi.org/10.1016/j.seppur.2005.11.037.

Full text

APA, Harvard, Vancouver, ISO, and other styles

Mahwish, Farhan Saeed, M. Tauseef Sultan, et al. "Bitter Melon (Momordica charantia L.) Fruit Bioactives Charantin and Vicine Potential for Diabetes Prophylaxis and Treatment." Plants 10, no. 4 (2021): 730. http://dx.doi.org/10.3390/plants10040730.

Full text

Abstract:

Natural products are gaining clinical significance in modern day health care systems to prevent diseases. Bitter melon, a health promoting vegetable, is traditionally used for medical nutrition therapy to cure diabetes but to reap maximum health claims, vigilant control of its substances in diet is crucial as part of curative action for effective diabetes management. In the present research, first phase focused on detection of key bioactive components, i.e., charantin and vicine in different parts of its fruit. In the second phase, normal and hyperglycemic Sprague Dawley rats were fed on skin, flesh and whole fruit of bitter melon at 150 and 300 mg/kg body weight and assessed for diabetes prophylaxis and treatment. The highest amount of charantin (0.16 ± 0.02 mg/g) was recorded in flesh while vicine was present in abundance in whole fruit (0.21 ± 0.01 μg/100 g). In normal rats, bitter melon supplementation was helpful in managing the onset of diabetes. Hyperglycemic rats showed diabetic complications including polydipsia, polyuria, glycosuria, renal hypertrophy and increased glomerular filtration rate. However, bitter melon consumption showed significant improvements in these parameters. The most potent dose was 300 mg/kg whole fruit that resulted in 31.64% lowering of blood glucose level and 27.35% increase in insulin level in hyperglycemic rats.

APA, Harvard, Vancouver, ISO, and other styles

Kuanhut, Wichuta, Thammarat Aree, Surachai Pornpakakul, and Pattara Sawasdee. "Novel Cucurbitane Triterpenoids and Anti-cholinesterase Activities of Constituents from Momordica charantia L." Natural Product Communications 9, no. 6 (2014): 1934578X1400900. http://dx.doi.org/10.1177/1934578x1400900609.

Full text

Abstract:

The C-19 epimers of 5β,19-epoxycucurbita-6,23( E),25(26)-triene-3β,19-diol (1) and 5β,19-epoxy-25-methoxycucurbita-6,23-diene-3β,19-diol (2) along with (19 R, 23 E)-5β,19-epoxy-19-methoxycucurbita-6,23,25-trien-3β-ol (3), (23 E)-5β,19-epoxycucurbita-6,23-diene-3β,25-diol (4), ligballinol (5), charantin (6) and momordicoside K (7) were isolated from the green fruits of Momordica charantia. The ( S)-epimers of 1 and 2 are the first reports in nature. The acetyl- and butyryl-cholinesterase inhibitory activities of the isolated compounds were evaluated, and 5 showed the highest activity of these compounds against butyrylcholinesterase (IC50 = 32.20 μM) with a reversible and non-competitive inhibition mode.

APA, Harvard, Vancouver, ISO, and other styles

Cuong, Do Manh, Jin Jeon, Abubaker M. A. Morgan, et al. "Accumulation of Charantin and Expression of Triterpenoid Biosynthesis Genes in Bitter Melon (Momordica charantia)." Journal of Agricultural and Food Chemistry 65, no. 33 (2017): 7240–49. http://dx.doi.org/10.1021/acs.jafc.7b01948.

Full text

APA, Harvard, Vancouver, ISO, and other styles

Singh, Shivali, Anshu Sharma, Rahul Reddy K, and Mahesh Kumar Samota. "Eco-Friendly Processing of Momordica Charantia L. Based Chemical Free Functionally Enriched Nectar And Evaluation of Its Nutritional Profile." Bangladesh Journal of Botany 51, no. 3 (2022): 445–53. http://dx.doi.org/10.3329/bjb.v51i3.61990.

Full text

Abstract:

The study was conducted to utilize functional attributes of Momordica charantia juice extract by mixing with papaya pulp for imparting yellow-orangecolour of its carotenoids and aonla juice with high Vitamin C to develop Momordica charantia blended functional nectar beverage without any preservative and synthetic food colorant. The ratio of 50 : 25 : 25 of bitter gourd juice extract, aonla juice and papaya pulp with best sensory scores on a nine-point hedonic scale was optimized for the processing of the blended beverage. Functional profile in terms of quality attributes such as reducing sugars (8.39%), DPPH activity (64.20%), total phenolics (41 mg/100 ml), carotenoids (0.58 mg/100 ml), and ascorbic acid (28.8 mg/100 ml) were recorded best in organic honey-based spiced blended nectar. However, charantin content (0.111 mg/100 ml) was found highest in plain bitter gourd beverage. Organoleptic scores and rich functional profile recorded during studies strongly indicated a positive perception of consumers and the need for commercialization. Bangladesh J. Bot. 51(3): 445-453, 2022 (September)

APA, Harvard, Vancouver, ISO, and other styles

Kusuma, Ikhwan Yuda, and Yuli Yuli Maesaroh. "THE PARE FRUIT ACTIVITY (Momordica charantia L.) AS HERBAL ANTI-HYPERGLYCEMIC FOR DIABETES MELLITUS CONDITIONS: LITERATURE REVIEW." JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X 12, no. 2 (2020): 186–93. http://dx.doi.org/10.35617/jfionline.v12i2.20.

Full text

Abstract:

Diabetes Melitus (DM) merupakan gangguan metabolik yang ditandai dengan glukosa darah tinggi (hiperglikemia) dan gangguan metabolisme karbohidrat, lemak, dan protein akibat efek pada sekresi insulin dan sensitivitas insulin. Antidiabetes oral merupakan salah satu pilihan terapi untuk mengontrol glukosa darah meskipun penggunaannya berpotensi munculnya efek samping dan sangat merugikan terutama dalam penggunaan jangka panjang. Terapi komplementer berbahan herbal seperti buah pare (Momordica charantia L.) menjadi aspek potensial untuk menjadi terapi alternatif karena potensi efek samping yang lebih rendah dan biaya yang terjangkau. Studi ini menjelaskan mengetahui aktivitas buah pare (Momordica charantia L.) sebagai antihiperglikemia. Jenis penelitian ini adalah penelitan kajian literatur (literature review) yang dipaparkan secara deskriptif. Metode pencarian literatur menggunakan jurnal internasional dan nasional dengan sumber data sekunder yang dilakukan secara online dan diidentifikasi menggunakan database elektronik dari PubMed, Science Direct dan Google Scholar. Proses pengumpulan data menggunakan pendekatan PICO (Population, Intervention, Compare, Outcame). Hasil penelitian ini diketahui bahwa buah pare (Momordica charantia L.) mengandung senyawa antidiabetes diantaranya charantin dan polipeptida-p. Buah pare baik dalam bentuk ekstrak maupun non-extract dan dalam sediaan tunggal maupun kombinasi terbukti menurunkan kadar glukosa darah, meningkatkan sensitivitas dan kadar insulin, menormalkan kadar HbA1c, memperbaiki profil lipid serta mengurangi stres oksidatif. kesimpulan penelitian ini adalah buah pare sangat berpotensi sebagai herbal antihiperglikemia pada kondisi diabetes

APA, Harvard, Vancouver, ISO, and other styles

Manisha, Chandrakar1 Neha Sharma2 Anjali Wahane3 Khomendra Kumar Sarwa4*. "Formulation And Evaluation of Momocardica Charantina Linn. Leaf Extracts Used to Treat Diabetes and Obesity." International Journal of Pharmaceutical Sciences 2, no. 11 (2024): 988–94. https://doi.org/10.5281/zenodo.14209448.

Full text

Abstract:

Diabetes and obesity are among the most frequent global health problems, and urban India has some of the highest rates. Due to the close relationship between obesity and type 2 diabetes, effective treatments, especially traditional medicine, are being sought for use in managing these diseases. A widely used tropical plant known for its healing abilities, especially in managing diabetes and obesity, is Momordica charantia – better known as the bitter melon. This study aimed to prepare and evaluate a medicinal syrup from Momordica charantia leaf extracts combined with Aloe vera gel, propylene glycol, methylparaben, and peppermint oil. Phytochemical analysis of the extracts indicated that they contain several bioactive components such as charantin, polypeptide-p, vicine, momordicoside, cucurbitacin B, gallic acid, epicatechin, isocercetin among others including momordicin I and II. These phytochemicals act by increasing glucose uptake inhibiting adipogenesis and modulating lipid metabolism thus contributing to their anti-obesity and anti-diabetic effects. The syrup was found to be physically and chemically stable while also possessing a good taste which makes it suitable for patient use. However, although no in vitro or in vivo tests were carried out in this study; based on the encouraging phytochemical profile as well as its stability Momordica charantia syrup should be considered as a potent theorist.

APA, Harvard, Vancouver, ISO, and other styles

Mir, ShowkatR, Javed Ahamad, and Saima Amin. "Optimization of ultrasound-assisted extraction of charantin from Momordica charantia fruits using response surface methodology." Journal of Pharmacy and Bioallied Sciences 7, no. 4 (2015): 304. http://dx.doi.org/10.4103/0975-7406.168032.

Full text

APA, Harvard, Vancouver, ISO, and other styles

William, Jessica Audrey, Vito Ananta, Ricky Fajar Adiputra, and Syarinta Adenina. "MOMORDICA CHARANTIA L. (PARE) SEBAGAI AGEN HIPOGLIKEMIK DALAM MANAJEMEN DIABETES MELITUS TIPE 2." Prominentia Medical Journal 6, no. 1 (2025): 28–40. https://doi.org/10.37715/pmj.v6i1.5489.

Full text

Abstract:

Latar Belakang: Diabetes melitus (DM) merupakan kondisi kadar gula darah tinggi persisten akibat gangguan metabolik kronis. DM tipe 2 mencakup 90% dari seluruh kasus diabetes melitus. Menurut laporan dari International Diabetes Federation (IDF) edisi ke-10, Indonesia berada pada peringkat ke-5 di dunia dengan jumlah penderita DM tipe 2 terbanyak (19,5 juta). Sebagai upaya mengatasi peningkatan kasus DM tipe 2, maka diperlukan manajemen efektif untuk mencapai sasaran kadar gula darah normal. Obat hipoglikemik oral (OHO) menjadi preferensi utama dalam pengobatan DM tipe 2. Namun, efek samping OHO menyebabkan kekhawatiran pada pasien DM tipe 2. Oleh sebab itu, diperlukan pendekatan lain, seperti terapi herbal tradisional berbasis tanaman untuk membantu menekan prevalensi kasus DM tipe 2. Metode: Pencarian literatur pada database PubMed, ScienceDirect, dan ClinicalKey. Artikel yang digunakan adalah yang dipublikasikan dalam 10 tahun terakhir, adapun kata kunci yang digunakan, antara lain “type 2 diabetes”, “Momordica charantia L.”, “bitter melon”, dan “blood glucose”. Hasil: Momordica charantia L. memiliki banyak senyawa yang memiliki khasiat antidiabetik. Kandungan tersebut antara lain polisakarida, peptida, terpenoid, saponin, alkaloid, flavonoid, dan lain-lain. Momordica charantia L. mengandung senyawa insulin mimetik mclRBP-19 yang ditemukan berhubungan dengan penurunan GDP dan HbA1c. Triterpenoid ditemukan dapat menstimulasi translokasi GLUT-4 pada sel otot dan lemak, serta inhibisi aktivitas PTP1B. Selain itu, charantin diketahui menghambat aktivitas DPP4. Simpulan: Momordica charantia L. memiliki potensi untuk menurunkan kadar glukosa darah pada pasien DM tipe 2 melalui komponen bioaktifnya.

APA, Harvard, Vancouver, ISO, and other styles

Kamaruddin, M. Yusril, and Armanto Makmun. "Laporan Kasus: Diabetes Melitus tipe 2 disertai Obesitas dengan Konsumsi Rebusan Buah Pare." Indonesian Journal of Health 4, no. 2 (2024): 67–72. https://doi.org/10.33368/inajoh.v4i2.115.

Full text

Abstract:

Diabetes melitus membutuhkan perawatan medis yang berkelanjutan karena merupakan kondisi yang berlangsung lama. Diabetes mellitus tipe 2 adalah jenis yang paling umum dan dipengaruhi oleh banyak variabel, termasuk lingkungan dan genetik. Disebabkan oleh urbanisasi, gaya hidup orang berubah, beralih dari makan makanan sehat ke makanan cepat saji. Dibandingkan dengan orang dengan berat badan normal, orang yang obesitas memiliki risiko diabetes tipe 2 empat kali lebih besar untuk mengontrol glukosa darah, pengobatan farmakologis dan non-farmakologi diperlukan dalam manajemen diabetes mellitus. Momordica Charantia, atau melon pahit, adalah tanaman alami yang dapat digunakan sebagai pengobatan alternatif untuk diabetes mellitus. Buah pear telah lama digunakan sebagai obat medis dan memiliki sifat hipoglikemik. Menurut studi literatur, bahan kimia charantin yang ditemukan dalam kacang-kacangan menunjukkan sifat yang mirip dengan insulin, membantu mengurangi kadar glukosa darah. Studi ini menunjukkan bahwa perawatan farmakologis dan penggabungan kacang sebagai terapi non-farmakologi dapat menurunkan kadar gula darah pada orang dengan diabetes mellitus.

APA, Harvard, Vancouver, ISO, and other styles

Fadhilah, Ira Nur, and Dwi Saryanti. "FORMULASI DAN UJI STABILITAS FISIK SEDIAAN TABLET EKSTRAK BUAH PARE (Momordica charantia L.) SECARA GRANULASI BASAH." Smart Medical Journal 2, no. 1 (2019): 25. http://dx.doi.org/10.13057/smj.v2i1.29676.

Full text

Abstract:

Bitter melon fruit is one type of medicinal plant used by the community. Charantin is one of the efficacious compounds contained in bitter melon fruit and can be used to reduce glucose levels in the blood. Tablets have advantage that are easy to consume and exactly the size, so in this study bitter melon is made from tablet preparations. The purpose of this study was to determine the concentration of gelatin binder which can produce tablets of bitter fruit extract (Momordica charantia L.) with good physical quality, and to determine the effect of gelatin as a binder on the physical stability test of bitter melon extract tablets (Momordica charantia L.) making bitter melon extract tablets is by wet granulation method, because the active ingredient of bitter melon fruit is not resistant to warming above 600C. Formulation tablets of bitter melon extract (Momordica charantia L.) with gelatin binder at a concentration of 5%, 7.5%, 10% able to produce tablets that meet the requirements of tablet physical examination for 28 days. Gelatin binding concentration has an effect on the physical properties of tablets, the best concentration of gelatin binder is formula III with 10% gelatin concentration. The higher the concentration of the binding material, the higher the hardness, and fragility decreases. Keywords: Bitter Melon Extract (Momordica charantia L.), Gelatin binder, Wet Granulation.

APA, Harvard, Vancouver, ISO, and other styles

Desai, Sonal, Pratima Tatke, Tukaram Mane, and Satish Gabhe. "Isolation, characterization and quantitative HPLC-DAD analysis of components of charantin from fruits of Momordica charantia." Food Chemistry 345 (May 2021): 128717. http://dx.doi.org/10.1016/j.foodchem.2020.128717.

Full text

APA, Harvard, Vancouver, ISO, and other styles

Srinivasulu, B., S. S. Vijaya Padma, L. M. Paratpara Rao, Ch Kiran Kumar, and V. Sekhar. "Assessment of Bitter Gourd Hybrids for Charantin and Other Vital Qualitative Traits." Environment and Ecology 42, no. 2 (2024): 509–15. http://dx.doi.org/10.60151/envec/nghc6017.

Full text

Abstract:

A field experiment was conducted in the Vegetable Experimental Field, College of Horticulture in Venkataramannagudem, Andhra Pradesh, during the summer and kharif seasons of 2022 in order to identify parents and cross combinations which have performed best for major quality attributes. To generate 21 F1 crosses, seven parents were maintained in a parental block (Summer 2022) and crossed in a half diallel mating pattern. For quality parameters like TSS, vitamin-C and iron the crosses viz., Preethi× Special Boldar, Kashi Mayuri× IC -68314, IC-68314 × Special Boldar were identified as promising ones. Charantin is important quality attribute, which was reported to be anti-diabetic in nature. Kashi Mayuri × IC-68314, IC-433630 × IC-68314 and IC-68314 × Special Boldar among the hybrids while IC-68314, IC-469512 and IC-433630 among the parents were found to be best performers for the charantin content in fruits. The identified promising crosses were further evaluated under multilocational trails and various seasons to know the potentiality before commercial release.

APA, Harvard, Vancouver, ISO, and other styles

Parkash, A., T. B. Ng, and W. W. Tso. "Purification and characterization of charantin, a napin-like ribosome-inactivating peptide from bitter gourd (Momordica charantia ) seeds." Journal of Peptide Research 59, no. 5 (2002): 197–202. http://dx.doi.org/10.1034/j.1399-3011.2002.00978.x.

Full text

APA, Harvard, Vancouver, ISO, and other styles

Pramesthi, Asri Dwi Endah Dewi, Mirhansyah Ardana, and Niken Indriyanti. "Drug-Herb Interaction between Metformin and Momordica charantia in Diabetic Mice." Molecular and Cellular Biomedical Sciences 3, no. 2 (2019): 81. http://dx.doi.org/10.21705/mcbs.v3i2.47.

Full text

Abstract:

Background: Bitter gourd has various metabolites, such as momordicosides, polypeptide-P, v-insulin, charantin, and vicine that have antidiabetic effect. It has synergistically effect while combined with oral diabetic drugs, such as metformin as glucose lowering agent. The aim of this study is to investigate the interaction of bitter gourd fruit juice and metformin as glucose lowering agent in mice.Materials and Methods: Alloxan-induced diabetic mice were treated with bitter gourd fruit juice, metformin, and the combination of those two for 21 days. Glucose level was checked on first and last day of treatment.Results: Furthermore, blood glucose levels measurement showed no significant difference between groups compared with negative control, which was p>0.05. The stomach of groups that treated with metformin and bitter gourd fruit juice histopathologically showed no significant differences.Conclusion: The use of bitter gourd once daily together with metformin is a better choice, while twice daily might induce hypoglycemia and mice death. There is no interaction between them on lowering blood glucose.Keywords: metformin, Momordica charantia, diabetes mellitus

APA, Harvard, Vancouver, ISO, and other styles

Nasution, Hasriati, Asmadi Saad, Yusfaneti, and Sri Mulyati. "Pupuk NPK Phoska dalam Meningkatkan Produksi Buah Pare di Kelompok Tani Sumber Rezeki, Jambi." Studium: Jurnal Pengabdian Kepada Masyarakat 4, no. 2 (2024): 55–62. https://doi.org/10.53867/jpm.v4i2.116.

Full text

Abstract:

Tanaman pare (Momordica charantia L.) memiliki nilai ekonomi dan manfaat kesehatan yang tinggi berkat kandungan saponin, flavonoid, polivenol, glikosida cucurbitacin, momordicin, dan charantin di dalamnya. Untuk mencapai produksi buah yang optimal, pemenuhan unsur hara melalui pemberian pupuk majemuk sangat penting. Penelitian ini bertujuan untuk meningkatkan keterampilan Kelompok Tani Sumber Rezeki di Desa Mendalo Indah, Kecamatan Jambi Luar Kota, Kabupaten Muaro Jambi, dalam budidaya pare melalui penyuluhan dan pemberian pupuk NPK Phoska. Metode yang digunakan meliputi penyuluhan materi pemupukan NPK Phoska dan demonstrasi langsung penanaman pare di lahan petani. Fasilitas yang disediakan antara lain bibit pare, pupuk NPK Phoska, alat pertanian (parang, cangkul, ember), timbangan, serta materi pendukung seperti alat peraga dan konsumsi selama demonstrasi. Hasil penelitian menunjukkan bahwa peserta penyuluhan sangat antusias, aktif dalam diskusi, dan memahami cara menentukan dosis pemberian pupuk NPK Phoska. Pemberian pupuk NPK Phoska diharapkan dapat meningkatkan pertumbuhan tanaman pare dan menghasilkan buah yang lebih lebat. Kesimpulannya, penyuluhan dan pemberian pupuk NPK Phoska efektif dalam meningkatkan keterampilan serta produktivitas kelompok tani dalam budidaya pare.

APA, Harvard, Vancouver, ISO, and other styles

Nirnadia, Nirnadia, Laila Kamilla, and Herlinda Djohan. "Potensi Pare (Momordica Charantia Linn) Sebagai Antidiabetes." Jurnal Laboratorium Khatulistiwa 4, no. 1 (2020): 34. http://dx.doi.org/10.30602/jlk.v4i1.942.

Full text

Abstract:

Diabetes mellitus merupakan penyakit menahun degeneratif yang ditandai dengan adanya kenaikan kadar gula di dalam darah yang disebabkan oleh kerusakan kelenjar pankreas sebagai penghasil hormon insulin. Pengobatan tradisional untuk terapi diabetes mellitus dianggap lebih aman dan dapat meminimalkan efek samping terhadap tubuh. Pare (Momordica charantia) merupakan tanaman terna semusim yang memiliki aroma bau khas dan rasa yang pahit mengandung senyawa kimia berupa flavonoid, saponin, steroid, tritepenoid, alkaloid, vicine, polipeptida, momordin, charantin dan polipeptida yang dapat menurunkan kadar glukosa dalam darah.Tujuan kajian literatur ini adalah mengkaji potensi pare dan mekanismenya sebagai antidiabetes. Pare memiliki kemampuan untuk menurunkan kadar glukosa darah dengan cara memiliki fungsi sebagai antioksidan untuk menurunkan resistensi insulin, meningkatkan sensitivitas insulin, asupan glukosa jaringan, sintesis glikogen otot hati, oksidasi glukosa, menurunkan glukoneogenesis hati, dan menekan absorbsi glukosa pada usus. Jenis penelitian yang digunakan adalah kajian literatur. Sumber basis data yang digunakan adalah sumber data sekunder yang diperoleh dengan melakukan penelusuran sumber pustaka melalui database Google scholar, PubMed, freefullpdf dan Google Book.Berdasarkan hasil kajian literatur didapatkan 16 jurnal, 14 jurnal dengan subjek penelitian terhadap hewan coba dan 2 jurnal secara in-vitro yaitu 1 jurnal terhadap flavonoid dari ekstrak daun pare metode nellson somogyi dan 1 jurnal terhadap isolasi polipeptida k dan minyak dari ekstrak biji pare. Dari 16 jurnal tersebut, 1 jurnal menyatakan bahwa ekstrak etanol pare 2% terhadap hewan coba tikus pada dosis 50 mg/kgBB sudah mampu menurunkan kadar glukosa darah. Kesimpulan dari hasil kajian literatur didapatkan adanya potensi pare (Momordica charantia) sebagai antidiabetes.

APA, Harvard, Vancouver, ISO, and other styles

Kim, Yong Kyoung, Woo Tae Park, Md Romij Uddin, et al. "Variation of Charantin Content in Different Bitter Melon Cultivars." Asian Journal of Chemistry 26, no. 1 (2014): 309–10. http://dx.doi.org/10.14233/ajchem.2014.15338.

Full text

APA, Harvard, Vancouver, ISO, and other styles

Jamil, Anna Moslihat, Maya Melati, and Sandra Arifin Aziz. "Plant growth, fruit production, and total terpenoid production in bitter melon (Momordica charantia L.) with guano fertilizer application." Jurnal Agronomi Indonesia (Indonesian Journal of Agronomy) 52, no. 3 (2024): 340–48. https://doi.org/10.24831/jai.v52i3.60164.

Full text

Abstract:

Bitter melon (Momordica charantia L.) is valued for its anti-diabetic properties due to terpenoid compounds like charantin, but production struggles to meet market demands. This study aimed to analyze the response of plant growth characteristics, fruit production, and terpenoid compound production in bitter melon fruit by improving phosphorus availability through guano fertilizer application as additional organic fertilizer in organic cultivation. The experiment was conducted from May to September 2024 at the IPB experimental station in Cikarawang, Bogor, Indonesia. The experiment used a randomized complete block design with varying guano fertilizer doses (0, 152, 304, and 456 g per plant). Observations were conducted on 10 sample plants per experimental unit. The observed characteristics included vegetative and reproductive growth, fruit production, and total terpenoid production. Terpenoid analysis was performed using a colorimetric method with an ELISA reader. The results showed that guano fertilizer significantly affected several plant growth and production variables. Higher doses increased several values of vegetative growth parameters, flower numbers, and fruit production. The 304 g guano per plant yielded the highest concentration and production of terpenoids. This study demonstrates the potential of guano fertilizer to enhance bitter melon growth, yield, and terpenoid content, contributing to improved production to meet market demands. Keywords: net assimilation rate; organic; phosphorus; relative growth rate

APA, Harvard, Vancouver, ISO, and other styles

Rahul, Kumar, Kathane Sudhir, Tanwar Ashwani, and Jain Ritesh. "Exploring the Efficacy of Herbal Antidiabetic Preparations: A Review of Current Research and Future Directions." International Journal of Clinical Endocrinology and Metabolism 11, no. 1 (2025): 014–19. https://doi.org/10.17352/ijcem.000066.

Full text

Abstract:

Diabetes mellitus, particularly type 2 diabetes, continues to pose a significant global health burden, with increasing prevalence, healthcare costs, and long-term complications. Conventional treatments, including insulin therapy and oral hypoglycemic agents, although effective, often come with limitations such as side effects, high costs, and reduced patient compliance. In this context, herbal antidiabetic preparations have gained growing attention as alternative and complementary therapeutic options, driven by traditional medicinal knowledge and an increasing body of scientific evidence. This review explores the efficacy, mechanisms of action, and therapeutic potential of various herbal formulations in the management of diabetes, while also identifying gaps in current research and proposing future directions. A wide range of medicinal plants, including Momordica charantia (bitter melon), Gymnema sylvestre, Trigonella foenum-graecum (fenugreek), Cinnamomum verum (cinnamon), and Berberis aristata, have demonstrated hypoglycemic activity in both experimental and clinical studies. These herbs contain bioactive constituents such as charantin, gymnemic acids, berberine, trigonelline, and cinnamaldehyde, which act through multiple mechanisms. These include enhancing insulin secretion, regenerating pancreatic beta cells, improving insulin sensitivity, inhibiting intestinal glucose absorption, and exerting antioxidant and anti-inflammatory effects. Unlike synthetic drugs that typically target a single pathway, herbal preparations often provide a multifaceted approach, making them particularly suitable for the complex pathophysiology of diabetes.

APA, Harvard, Vancouver, ISO, and other styles

Roy, Anwesh, Anindita Chakraborty, Muthummal Sudarshan, Sayak Gangulic, and Sarmistha Sen Raychaudhuri. "Trace elements study using x-ray fluorescence, charantin accumulation and squalene synthase gene expression in different Momordica charantia Linn fruit." African Journal of Biological Sciences 4, no. 2 (2022): 57. http://dx.doi.org/10.33472/afjbs.4.2.2022.57-76.

Full text

APA, Harvard, Vancouver, ISO, and other styles

Setiawan, Haris, and Roby Ahmad Subagja. "Pengaruh Pemberian Jus Pare (Momordica charantia L.) Terhadap Kualitas Sperma dan Histologi Testis Tikus Wistar." Al-Kauniyah: Jurnal Biologi 17, no. 1 (2023): 10–20. http://dx.doi.org/10.15408/kauniyah.v16i2.1.23216.

Full text

Abstract:

AbstrakBuah pare merupakan salah satu kandidat agen kontrasepsi karena memiliki beberapa senyawa seperti flavonoid, triterpenoid, steroid, charantin, dan momordicin yang memiliki peran sebagai agen antispermatogenik. Penelitian bertujuan untuk mengetahui pengaruh pemberian jus pare (Momordica charantia L.) terhadap kualitas sperma dan histologi testis tikus Wistar (Rattus norvegicus Berkenhout, 1769). Penelitian menggunakan 20 ekor tikus Wistar jantan, dibagi menjadi 4 perlakuan yang terdiri dari kelompok pemberian akuades (K), kelompok pemberian jus pare konsentrasi 25% (P1), 50% (P2), dan 75% (P3) yang dilakukan selama 49 hari menggunakan sonde lambung 1 mL. Pada hari ke-50 tikus dibedah untuk diambil cauda epididymis dan testis. Cauda epididymis dilarutkan ke dalam Phospate Buffer Saline (PBS) untuk pengamatan kualitas sperma yang terdiri dari motilitas, jumlah, viabilitas, dan morfologi sperma. Testis dibuat sediaan histologi dengan metode parafin (pewarnaan Hematoxylin-Eosin). Seluruh parameter dianalisis menggunakan uji One-Way Anova dan dilanjutkan Duncan test (P <0,05). Hasil menunjukkan terdapat penurunan motilitas, viabilitas, dan jumlah sperma pada konsentrasi 50% dibandingkan dengan kontrol (P <0,05), namun tidak terdapat perbedaan pada morfologi sperma (P >0,05). Terdapat penurunan jumlah sel spermatogonium, spermatosit, dan spermatozoa pada konsentrasi 25% dibandikan dengan kontrol (P <0,05), namun tidak terlihat penurunan pada sel spermatid dan index spermatogenesis (P >0,05). Jus pare dapat menurunkan sebagian besar parameter kualitas sperma sehingga berpotensi sebagai antispermatogenik.AbstractBitter melon fruit is one of the candidates for contraceptive agents because it contains several compounds such as flavonoids, triterpenoids, steroids, charantin, and momordicin which have a role as antispermatogenic agents. The research aims to determine the effect of giving bitter melon juice (Momordica charantia L.) on sperm quality and testicular histology of Wistar rats (Rattus norvegicus Berkenhout, 1769). The study used 20 male Wistar rats, divided into 4 treatments consisting of groups given distilled water (K), groups given bitter melon juice with concentrations of 25% (P1), 50% (P2), and 75% (P3) which were carried out for 49 days. using a 1 mL gastric probe. On the 50th day, mice were dissected to remove the cauda epididymis and testes. The cauda epididymis is dissolved in Phosphate Buffer Saline (PBS) to measure sperm quality consisting of sperm motility, number, viability and morphology. Testes were made into histological preparations using the paraffin method (Hematoxylin-Eosin staining). All parameters were analyzed using the One-Way Anova test and continued with the Duncan test (P<0.05). The results showed that there was a decrease in sperm motility, viability and number at a concentration of 50% compared to the control (P<0.05), but there was no difference in sperm morphology (P>0.05). There was a decrease in the number of spermatogonium cells, spermatocytes and spermatozoa at a concentration of 25% compared to the control (P<0.05), but there was no visible decrease in spermatid cells and spermatogenesis index (P>0.05). Bitter melon juice can reduce most sperm quality parameters so it has the potential to be antispermatogenic.

APA, Harvard, Vancouver, ISO, and other styles

Sadique, Saqulain1 Makrand Verma2 Harjot Singh3 Sudhahar Dharmalingam4 Eldhose. M. J.5 Yash Srivastav6 Konda V. V. S. Krishna7 Tejas Ghadge8 Anil Kumar*9. "Therapeutic Role of Gymnema sylvestre and Momordica charantia in Diabetes Management: A Detailed Review of Their Mechanisms in Insulin Resistance, Glucose Metabolism Regulation, and Clinical Efficacy in Type 2 Diabetes Mellitus." International Journal of Pharmaceutical Sciences 3, no. 2 (2025): 1757–68. https://doi.org/10.5281/zenodo.14902101.

Full text

Abstract:

Type 2 Diabetes Mellitus (T2DM) is a chronic metabolic disorder characterized by insulin resistance, β-cell dysfunction, and impaired glucose metabolism. While conventional treatments like metformin and insulin therapy are widely used, interest in herbal and alternative medicine has grown due to their potential efficacy, fewer side effects, and complementary mechanisms.Among the promising botanical agents, Gymnema sylvestre and Momordica charantia have demonstrated antidiabetic properties in preclinical and clinical studies. Objectives: This review aims to: Examine the pathophysiology of T2DM, focusing on insulin resistance, glucose dysregulation, and oxidative stress. Analyze the mechanisms of action of Gymnema sylvestre and Momordica charantia in improving insulin sensitivity, stimulating insulin secretion, and regulating glucose metabolism. Evaluate clinical studies assessing their effectiveness in diabetes management. Compare their pharmacological effects and explore their potential for synergistic use. Highlight future research directions for improving their clinical applications. Methods: A comprehensive literature review was conducted using databases like PubMed, Scopus, and Google Scholar to identify in vitro, in vivo, and human clinical studies on Gymnema sylvestre and Momordica charantia in diabetes management. Relevant articles were selected based on mechanistic insights, clinical evidence, and safety considerations. Results” Gymnema sylvestre contains gymnemic acids, saponins, and flavonoids, which enhance insulin secretion, regenerate pancreatic β-cells, inhibit intestinal glucose absorption, and improve glucose uptake in peripheral tissues. Momordica charantia contains charantin, polypeptide-p, and vicine, which mimic insulin action, regulate glucose metabolism, and exert antioxidant and anti-inflammatory effects. Clinical trials suggest significant reductions in fasting blood glucose (FBG), postprandial glucose (PPG), and HbA1c in patients consuming extracts of these plants. However, variability in phytochemical composition and dosing regimens limits standardization. Comparative analysis shows overlapping mechanisms of action, suggesting that combining these herbs may have additive or synergistic benefits in glycemic control. Research gaps include a lack of large-scale, long-term clinical trials, inconsistencies in extract standardization, and insufficient safety data for chronic use. Conclusions: Gymnema sylvestre and Momordica charantia exhibit promising antidiabetic properties through multiple mechanisms, including insulin secretion enhancement, glucose uptake facilitation, and oxidative stress reduction. While existing evidence supports their potential as adjuncts to conventional diabetes therapies, further randomized controlled trials (RCTs), phytochemical standardization, and formulation innovations are needed to ensure efficacy, safety, and clinical integration.

APA, Harvard, Vancouver, ISO, and other styles

Deviana, Katerina Zielda, and Diniatik Diniatik. "Analisis Penambatan Molekuler dan Prediksi Toksisitas dan ADME Penghambat Enzim Dipeptidil Peptidase IV dari Senyawa Aktif Momordica charantia L. sebagai Antidiabetes." PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) 18, no. 2 (2021): 361. http://dx.doi.org/10.30595/pharmacy.v18i2.8556.

Full text

Abstract:

Angka kejadian penyakit diabetes melitus (DM) di Indonesia terus meningkat setiap tahunnya, khususnya diabetes melitus tipe II yang disebabkan oleh resistensi insulin pada sel-sel tubuh. Salah satu pengobatan diabetes tipe II yang saat ini sedang dikembangkan adalah inhibitor enzim dipeptidyl peptidase IV (DPP-IV). Banyak digunakan sebagai obat herbal, pare (Momordica charantia L.) mengandung senyawa yang bersifat antidiabetes, sehingga berpotensi sebagai inhibitor DPP-IV. Penelitian ini bertujuan untuk memprediksi potensi penghambatan dan beberapa prinsip aktif pare terhadap aktivitas enzim DPP-IV secara in silico melalui penambatan molekuler. Data tersebut diolah dengan metode doking molekuler menggunakan program PyRx-Vina didukung dengan program PyMOL dan PLIP untuk membuat profil visual ligan-protein, ligan alami PF2 digunakan sebagai ligan pembanding dengan 18 senyawa uji. Molekul dengan hasil doking terbaik akan diprediksi toksisitasnya menggunakan program Toxtree dan absorbsi, distribusi, metabolisme, dan eliminasi (ADME) menggunakan program SwissADME secara online. Hasil doking menunjukkan charantin dan oleanolic acid memiliki binding affinity (ΔG) terendah yaitu -9.8 Kkal/mol dan -8.9 Kkal/mol, sedangkan ligan alami -8.7 Kkal/mol. Hasil prediksi toksisitas menunjukkan bahwa hanya ada satu senyawa yang memiliki toksisitas rendah (oleanolic acid) serta semua senyawa tidak bersifat karsinogenik. Hasil ADME menunjukkan bahwa hanya ada satu senyawa yang memenuhi aturan Lipinski (epicatechin). Hasil penambatan molekuler dengan metode PyRx-Vina menunjukkan bahwa senyawa aktif dari tanaman pare secara in silico terbukti dapat menghambat DPP-IV.

APA, Harvard, Vancouver, ISO, and other styles

& Al-jebory, Al-asadi. "EFFECT OF SPRAYING AMINO ACIDS ON GROWTH AND YIELD OF BITTER GOURD PLANT GENOTYPES Momordica charantia L. AND ITS CHARANTIN CONTENT." IRAQI JOURNAL OF AGRICULTURAL SCIENCES 51, no. 4 (2020): 991–1000. http://dx.doi.org/10.36103/ijas.v51i4.1078.

Full text

Abstract:

This Experiment was carried out in the plastic houses , College of Agricultural Engineering Sciences , University of Baghdad during the spring season 2018. Six inbred lines of bitter gourd were crossed full diallel crosses and planted during season 2018-2019 (six inbred lines +15 diallel hybrid + 15 Reciprocal hybrid + control hybrid). These genotypes were studied under the influence of amino acid spraying. This experiment was carried out using the split-plot design included two factors: The first factor represents amino acid spraying with control treatment and spraying phenylalanine amino acid at a concentration of 50 mg/L, and spraying Tyrosine amino acid at 100 mg/L with three times during the growing season. Represents the main plot were distributed randomly on three replicates.The second factor represents 37 genotypes of the bitter gourd represents Subplot. The results were showed highest that the interaction [T (5 × 4)] had total chlorophyll concentration in leaves (29.11 mg .g-1) , percentage of fruit setting (86.95%), fruit weight (122.6 g). While the interaction P (2×3) had the highest charnitin yield in the plant (0.857 g). The hybrid(2×3) gave the highest charantine in the plant (0.760 g).

APA, Harvard, Vancouver, ISO, and other styles

Aumeeruddy, Muhammad Zakariyyah, and Mohamad Fawzi Mahomoodally. "Ethnomedicinal Plants for the Management of Diabetes Worldwide: A Systematic Review." Current Medicinal Chemistry 28, no. 23 (2021): 4670–93. http://dx.doi.org/10.2174/0929867328666210121123037.

Full text

Abstract:

Background: The increasing incidence of diabetes worldwide has urged researchers to explore novel antidiabetic agents from natural products. Ethnomedicinal field studies on diabetes have expanded across the globe, documenting large numbers of folk medicinal plants against diabetes. Nonetheless, a systematic review of these surveys has not been conducted so far. This study documents the medicinal plants traditionally used globally for managing diabetes. Methods: Key databases including Sciencedirect, Medline/PubMed, and Google Scholar were scrutinized. The Plant List and The International Plant Names Index (IPNI) were used to validate the scientific plant names. Results: 2004 traditionally used plants belonging to 1112 genera and 197 families were reported across 92 countries for the management of diabetes. Leguminosae (105 genera and 193 species), Compositae (97 genera and 188 species), and Lamiaceae (47 genera and 121 species) were the main plant families reported. Momordica charantia L., Syzygium cumini (L.) Skeels, Allium sativum L., Azadirachta indica A.Juss., Catharanthus roseus (L.) G.Don, Olea europaea L., Trigonella foenum-graecum L., Gymnema sylvestre (Retz.) R.Br. ex Sm., Aloe vera (L.) Burm.f., and Allium cepa L were the species mostly reported. Indeed, the antidiabetic properties of these main species have been evidenced by experimental studies. Several antidiabetic compounds acting via different mechanisms have been identified, including momordicoside, karaviloside, cucurbitacin, charantin, and charantoside from M. charantia, cuminoside from S. cumini, S-allyl cysteine sulfoxide from A. sativum, limonoids from A. indica, alkaloids including vindoline, vindolidine, vindolicine and vindolinine from C. roseus, oleuropein and oleanolic acid from O. europaea, flavone C-glycosides such as vicenin-1, isoschaftoside, and schaftoside from T. foenum-graecum seeds, gymnemosides, gymnemagenin, and pregnane glycosides from G. sylvestre, chysalodin from A. vera, and quercetin from A. cepa. Conclusion: This review is the first to provide a compiled list of traditional medicinal plants used worldwide against diabetes.

APA, Harvard, Vancouver, ISO, and other styles

ma K V, Nirupa, Adlin Jino Nesalin J, and Tamizh Mani T. "Preparation and Evaluation of Microparticles Containing Charantin by Solvent Evaporation Technique." International Journal of Pharmacy and Biomedical Engineering 6, no. 1 (2019): 24–28. http://dx.doi.org/10.14445/23942576/ijpbe-v6i1p103.

Full text

APA, Harvard, Vancouver, ISO, and other styles

Nguyễn, Thị Mai, Anh Vũ Trần, Huệ Minh Nguyễn та Hữu Phúc Nguyễn. "Nghiên cứu công thức viên nang cứng chứa cao khổ qua rừng Momordica charantia". TẠP CHÍ KHOA HỌC TRƯỜNG ĐẠI HỌC QUỐC TẾ HỒNG BÀNG 24 (6 липня 2023): 63–72. http://dx.doi.org/10.59294/hiujs.24.2023.314.

Full text

Abstract:

Đặt vấn đề: Xu hướng sử dụng dược liệu và các sản phẩm từ dược liệu hiện nay rất phổ biến, thuốc từ dược liệu ngày càng phát triển mạnh, đặc biệt các thuốc dùng cho các bệnh lý mãn tính như tiểu đường, huyết áp, tim mạch. Mục tiêu nghiên cứu: Nghiên cứu công thức điều chế viên nang khổ qua rừng có tác dụng hỗ trợ hạ đường huyết cho bệnh nhân tiểu đường type 2 là điều cần thiết. Đối tượng và phương pháp nghiên cứu: Cao đặt khổ qua rừng cải thiện độ tan trong nước được dùng làm nguyên liệu chính cho viên nang khổ qua rừng, Xây dựng và thẩm định quy trình định lượng hoạt chất charantin bằng phương pháp HPLC, Xây dựng công thức, quy trình điều chế viên nang khổ qua rừng, xây dựng TCCS và kiểm tra thành phẩm theo TCCS. Kết quả: Đã xây dựng và thẩm định được quy trình định lượng charantin trong viên nang khổ qua rừng. Xây dựng được công thức viên nang khổ qua rừng với các thành phần theo tỷ lệ thích hợp gồm: cao đặc khổ qua rừng cải thiện 55%, calcium silicate 10%, hỗn hợp lactose monohydrat và avicel PH 101 với tỷ lệ 6:4 chiếm 34%, 1% talc. Tiến hành nâng cấp cỡ lô 2000 viên, thực hiện bào chế 3 lô pilot đạt độ ổn định về quy trình bào chế và tiêu chuẩn kiểm nghiệm.

APA, Harvard, Vancouver, ISO, and other styles

Nguyen, Trang T. T., та Ha V. H. Nguyen. "Effects of Fermentation Conditions Using Lactobacillus plantarum on the Charantin, Stigmasterol Glucoside and β-sitosterol Glucoside Contents of Bitter Gourd (Momordica charantia L.) Juice". Plant Foods for Human Nutrition 75, № 4 (2020): 656–58. http://dx.doi.org/10.1007/s11130-020-00860-w.

Full text

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!