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Journal articles on the topic "Chas. T. Main, Inc"
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Willoughby, Jay. "Confessions of an Economic Hit Man." American Journal of Islam and Society 22, no. 2 (April 1, 2005): 124–26. http://dx.doi.org/10.35632/ajis.v22i2.1719.
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Confessions of an Economic Hit Man is the story of why the so-calleddeveloping never seems to develop, as seen through the eyes of JohnPerkins, who was involved in “developing” several oil-rich nations. Theopening chapters deal with his childhood, which was permeated with elitismand ideas of how only the “right people” really mattered, his subsequentrebellion by defying his parents’ plan for his life, his initial contacts(through his wife) with government employment, and a 2-year Peace Corpsstint with an indigenous Indian tribe in Ecuador. While there, he wasrecruited by the National Security Agency. After his time was up, he washired by Chas. T. Main, Inc. to devise a 25-year forecast of seriously inflatedelectricity needs for Indonesia so that it would agree to take out an enormousloan. He did so, albeit with some misgivings, and his career as an economichit man (EMH) was launched.Claudine, his handler, made his task perfectly clear:We’re a small, exclusive club,” she said. “We’re paid – well paid – to cheatcountries around the globe out of billions of dollars. Alarge part of your jobis to encourage world leaders to become part of a vast network that promotesU.S. commercial interests. In the end, those leaders become ensnaredin a web of debt that ensures their loyalty. We can draw on them wheneverwe desire – to satisfy our political, economic, or military needs. In turn,these leaders bolster their political positions by bringing industrial parks,power plants, and airports to their people. Meanwhile, the owners of U.S.engineering and construction companies become very wealthy. (p. 17)Praised for his success, he was given “the opportunity, something fewmen ever receive, even at twice your age” (p. 57): to bring on boardPanama’s popular president, Omar Torrijos, who wanted all Panamanians,instead of only the small elite, to benefit. Torrijos’ assertion that sovereign ...
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Du, Wei-Shih, Young-Ye Huang, and Chi-Lin Yen. "Fixed point theorems for nonexpansive mappings on nonconvex sets in UCED Banach spaces." International Journal of Mathematics and Mathematical Sciences 31, no. 4 (2002): 251–57. http://dx.doi.org/10.1155/s0161171202107113.
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It is shown that every asymptotically regular orλ-firmly nonexpansive mappingT:C→Chas a fixed point wheneverCis a finite union of nonempty weakly compact convex subsets of a Banach spaceXwhich is uniformly convex in every direction. Furthermore, if{T i}i∈Iis any compatible family of strongly nonexpansive self-mappings on such aCand the graphs ofT i,i∈I, have a nonempty intersection, thenT i,i∈I, have a common fixed point inC.
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Ullah, Sami, Faiz Ahmad, and Anildav Singh. "Development and Testing of Intumescent Fire Retardant Coating on Various Structural Geometries." Applied Mechanics and Materials 699 (November 2014): 360–65. http://dx.doi.org/10.4028/www.scientific.net/amm.699.360.
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Materials are prone to fire and in modern construction their protection from fire is required. In any structure, various joints such as T-joint, I-beam and elbows are used. The geometry of the component has significant role in protection of structure. A weak joint may lead to failure of main structure. In order to meet these challenges, Intumescent fire retardant coating (IFRC) were developed and tested on various structural geometries such as T-joints, elbows, I-beams and pipe. The control coating formulation (IFC-C) was developed from main ingredients; Ammonium Polyphosphate (APP), expandable Graphite (EG), Melamine (Mel), Boric Acid (BA) mixed with bisphenol A epoxy resin and polyamide hardener. Another set of formulations containing various percentage of aluminium Tri-Hydrate (ATH). Fire test results of ATH based formulation showed that I-beam geometry showed the high expansion of 19 mm. T-joint showed the average surface temperature of 55°C after one hour of Bunsen burner test. The X-ray Diffraction (XRD) showed the presence of boron oxide, boron phosphate, sassolite and aluminium oxide in IFC-ATH5 residual char. The 5wt% ATH filler in IFC-C enhanced the fire protection performance of intumescent fire retardant coating formulation.
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Umekita, K., Y. Hashiba, R. Kudou, S. Miyauchi, M. Kimura, M. Matsuda, C. Iwao, et al. "AB0268 HUMAN T-CELL LEUKAEMIA VIRUS TYPE 1 MAY INVALIDATE T-SPOT.TB RESULTS AMONG RHEUMATOID ARTHRITIS PATIENTS: A RETROSPECTIVE OBSERVATIONAL STUDY." Annals of the Rheumatic Diseases 79, Suppl 1 (June 2020): 1432.1–1433. http://dx.doi.org/10.1136/annrheumdis-2020-eular.1588.
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Background:In clinical rheumatology, interferon-γ release assays (IGRAs) have been reported as a useful diagnostic test for latent tuberculosis infection (LTBI) before beginning the administration of biologics such as anti-TNF therapies (1). CD4-positive T cells are the main target in Human T-cell leukaemia virus type 1 (HTLV-1) infection. Several reports suggest that the reaction of tuberculin skin test (TST) is attenuated in HTLV-1-positive individuals compared with that in HTLV-1-negative individuals (2). However, it remains unclear whether IGRAs are reliable for detecting TB infection among HTLV-1-positive RA patients.Objectives:The present study aimed to investigate the usefulness of the T-SPOT.TBassay in HTLV-1-positive RA patients. In addition, the association between the existence of IFN-γ producing T cells and HTLV-1 proviral loads (PVLs) in HTLV-1-positive RA patients was analysed on the basis of the T-SPOT.TBassay results.Methods:We reviewed the medical records of 75 HTLV-1-negative and 29 HTLV-1-positive RA patients were suspected cases of LTBI and evaluated using the T-SPOT.TBassay as a clinical practice from April 2012 to July 2019. The results of T-SPOT.TBwere collected from medical records, retrospectively. Peripheral blood samples were obtained from HTLV-1-positive RA patients for the analysis of HTLV-1 PVLs values. The study protocol was approved by the research ethics committees of our hospitals.Results:Approximately 55% of the HTLV-1-positive RA patients showed invalid results for the T-SPOT.TBassay (p < 0.0001); the cause of invalid results was a spot-forming count of >10 spots in the negative controls of the T-SPOT.TBassay among HTLV-1-positive RA patients. Among HTLV-1-positive RA patients, HTLV-1 PVL values were significantly higher in 16 patients who showed invalid results than in 13 patients who did not (p = 0.003). There were no between-group differences in female patient ratio, age, RA disease activity and therapeutic regimens. IFN-γ producing cells were detected in the peripheral blood of HTLV-1-positive RA patients without stimulation with TB-specific antigens.Conclusion:The incidence of invalid results for the T-SPOT.TBassay has been reported to be as low as 0.6% (3). The results of this assay for screening of LTBI in HTLV-1-positive RA patients should be interpreted with caution. Furthermore, our results show that an increase in IFN-γ producing T cell numbers due to HTLV-1 infection in RA patients may affect the pathogenesis of RA.References:[1]Iannone, F., et al.J. Rheumatol. Suppl.91, 41-46 (2014).[2]Tachibana, N., et al.Int. J. Cancer42, 829-831 (1988).[3]Rego, K., et al.Tuberculosis (Edinb.)108, 178-185 (2018).Acknowledgments:We would like to thank Dr Yuki Hashikura and Ms Yuki Kaseda of the University of Miyazaki for their technical support in this work. We would also like to acknowledge Ms Yumiko Kai at the Institute of Rheumatology, Zenjinkai Shimin-no-Mori Hospital, for her help in data management.A part this work was supported by a grant from the Practical Research Project for Rare/Intractable Diseases of the Japan Agency for Medical Research and Development (Grant No. JP19ek0109356), a Health and Labor Sciences Research Grant on Rare and Intractable Diseases from the Ministry of Health, Labor and Welfare of Japan (Grant No. 19FC1007), and a Grant-in-Aid for Clinical Research from Miyazaki University Hospital.Disclosure of Interests:Kunihiko Umekita Paid instructor for: Astellas Pharma Inc. Chugai Pharma Inc. Tanabe-Mitsubishi Pharma Inc., Speakers bureau: Bristol-Myers Squibb, Yayoi Hashiba: None declared, Risa Kudou: None declared, Shunichi Miyauchi: None declared, Masatoshi Kimura: None declared, Motohiro Matsuda: None declared, Chihiro Iwao: None declared, Yumi Kariya: None declared, Takeshi Kawaguchi: None declared, Katoko Takajo: None declared, Koushou Iwao: None declared, Yuuki Rikitake: None declared, Ichiro Takajo: None declared, Toshihiko Hidaka Paid instructor for: Astellas Pharma Inc. Chugai Pharma Inc. Tanabe-Mitsubishi Pharma Inc., Speakers bureau: Astellas Pharma Inc. Chugai Pharma Inc. Tanabe-Mitsubishi Pharma Inc., Akihiko Okayama: None declared
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Barcellini, Wilma, Anna Ines Gregorini, Giulia Soverini, Anna Zaninoni, Juri A. Giannotta, Cristina Vercellati, Valeria Ferri, Paola Bianchi, Agostino Cortelezzi, and Maria Domenica Cappellini. "Iron Overload and Cytokine Serum Levels in Congenital Hemolytic Anemias." Blood 128, no. 22 (December 2, 2016): 2458. http://dx.doi.org/10.1182/blood.v128.22.2458.2458.
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Abstract Background: Congenital hemolytic anemias (CHAs) are a heterogeneous group of inherited RBC disorders including membrane and enzyme defects and dyserythropoietic anemias. Iron overload is a well recognized complication of hereditary hemoglobinopathies, both in transfusion-dependent and independent cases. However, little is known in congenital hemolytic anemias, with the exception of anecdotic reports in pyruvate kinase deficiency and dyserythropoietic anemias. Aim: to describe the clinical and hematological features at diagnosis and enrolment, to investigate iron overload by hepatic and cardiac T2* MRI, and to study inflammatory/regulatory cytokine profiles (IL-6, TNF-alpha, IFN-gamma, IL-10, IL-17) and hepcidin levels in patients with CHAs. Confounding factors such as hemocromatosis genotyping, metabolic syndrome, and hepatic viral profile were also considered. Methods: Between July 2015 and April 2016, 38 patients were enrolled (13 hereditary spherocytosis -HS, 3 hereditary stomatocytosis - HSt, 8 congenital dyserythropoietic anemia type II - CDAII, 13 pyruvate kinase deficiency - PKD, 1 glucose-phosphate isomerase deficiency). HS cases were enrolled on the basis of ferritin >300 ng/mL at diagnosis. Cytokine levels were detected in serum by ELISA. Comparisons were made by Students T test (continuous) and Fisher's exact test (categorical), and correlations by Pearson's linear coefficient. Results: The main clinical and hematological findings are shown in table. Median Hb values progressively decreased in the 4 groups considered, being close to normal in HS and moderately reduced in CDAII patients, whereas hemolytic parameters were comparable among groups. Consistently with clinical severity, ferritin values were particularly high in CDAII (together with transferrin saturation-TfS) and PKD patients, notwithstanding chelation in about half cases of both groups. Of note, only 2 PKD patients were transfusion-dependent, suggesting that other factors are involved in iron overload. Splenectomy had been performed in 17/38 (44.7%), mainly CDAII. Liver iron concentration (LIC) showed a great heterogeneity in all groups, with a trend towards higher values in CDAII; 16/36 (44%) patients had a LIC>4 mg/g DW (23%, 33%, 38% and 88% in HS, HSt, PKD and CDAII, respectively). Cardiac T2* value was normal in all subjects, with the exception of a HS and a CDAII case. Regarding possible cofactors, 12/16 displayed at least one of the following: 1 homozygous for HFE C282Y and 1 for H63D mutations, 3 HCV+, 4 BMI>25, 2 alcohol abuse, 3 heterozygous for HFE mutations. The following positive correlations were observed at enrolment: LIC and ferritin (r=0.68, p<0.05), LIC and TfS (r=0.34, p=0.05), and cardiac T2* and TfS (r=0.34, p<0.05). Moreover Hb values at diagnosis negatively correlated with LIC (r=0.37, p<0.05). Interestingly, among the 28 cases with ferritin <800 ng/mL, 10 (36%) displayed liver iron overload (LIC>4), of whom 5 with the above listed cofactors. As regards cytokine levels, IL-10 was significantly increased in HS, PKD and CDAII groups compared with normal cases; TNF-alpha was decreased in HS and PKD, and IFN-gamma increased in HS and CDAII. Ferritin values were positively correlated with IL-6 and IFN-gamma, and TfS negatively with IL-6 (r= -0.38, p<0.05). Hepcidin values were slightly increased in CHAs compared with normal controls, and correlated positively with ferritin (r=0.33; p<0.05), and negatively with TfS (r= -0.56; p<0.001). Finally, hepcidin levels were positively correlated with IL-6 (r=0.62; p<0.001), and negatively with IFN-gamma (r=0.3; p<0.05). Conclusion: Iron overload is highly prevalent in CHAs, particularly in PKD and CDAII, is independent from transfusion support, and is also observed in cases with ferritin <800 ng/mL. T2* MRI is the gold standard approach to evaluate iron overload in CHAs (as in other congenital anemias) and its use is advisable, particularly in the presence of cofactors, for early chelation. Cytokine studies suggest the existence of a positive loop among ferritin, hepcidin, and inflammatory cytokines such as IL-6 and IFN-gamma, and of a negative loop among TfS, hepcidin, and the same inflammatory cytokines. These findings disclose important hints to understand the multiple biological mechanisms of iron overload, and support the rationale for new emerging therapies. Table Table. Disclosures Barcellini: Agios: Consultancy.
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Tkachev, Victor, Frank Kuhnert, Scott N. Furlan, Hengqi Zheng, Daniel J. Hunt, Lucrezia Colonna, Judith M. Carlson, et al. "Pharmacologic Blockade of Notch/Delta-like Ligand 4 Signaling Protects from Gastrointestinal Acute Graft-Versus-Host Disease in Non-Human Primates." Blood 132, Supplement 1 (November 29, 2018): 2027. http://dx.doi.org/10.1182/blood-2018-99-110030.
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Abstract The Notch signaling pathway is an evolutionarily conserved, cell-cell communication system with critical functions in organogenesis and tissue homeostasis, including hemato- and immuno-poiesis. Recent data have revealed important roles for Notch in the regulation of mature T cell differentiation and function. Studies in mouse models have identified Notch as a critical regulator of pathogenic T-cell responses during acute GVHD (aGVHD) (Zhang Y, 2011, Blood). However, the exact biological effects and the therapeutic potential of Notch pathway manipulation in clinical settings remains unclear. To address this question, we tested the activity of Notch pathway blockade in a non-human primate (NHP) aGVHD model, previously shown to exhibit donor T cell-intrinsic activation of the Notch pathway during aGVHD (Furlan SN, 2015, Sci Transl Med). To inhibit the Notch pathway, we used a blocking mAb to the Notch ligand DLL4, identified as the dominant ligand in a mouse aGVHD model (Tran, 2013, JCI; Chung, 2017, JCI). Prophylactic treatment regimens with either a single administration of anti-DLL4 mAb on day 0 (3 mg/kg), or with 3 doses (3 mg/kg each) on days 0, 7 and 14 significantly improved GVHD-free survival of allo-HCT recipients (median survival time (MST) = 26.5 days for the single dose regimen, and MST = 26 days for the triple dose regimen) in comparison with unprophylaxed controls (MST = 8 days, p<0.005; Fig 1A). Importantly, donor cell engraftment and hematopoietic reconstitution were normal (Fig 1B). Of note, DLL4 blockade dramatically changed the clinical phenotype of break-through GVHD, providing complete protection from gastrointestinal (GI) aGVHD, and instead showing clinical manifestations predominantly restricted to liver (Fig 1C, D). We next sought to determine the mechanism of GI aGVHD protection caused by DLL4 inhibition. Notably, anti-DLL4 GVHD prophylaxis decreased the expression of the gut-homing α4β7 integrin on CD8 T cells from the peripheral blood, spleen, mesenteric lymph nodes and colon in treated recipients (Fig 2A). Intestinal CD8 T cells also displayed a skewing towards a mature, effector-memory phenotype (Fig 2B) and reduced Ki67+ proliferation (Fig 2C). In contrast, CD8 T cells isolated from liver, the main site of break-through GVHD in anti-DLL4 mAb-treated animals, demonstrated a similar proliferation rate in anti-DLL4-treated compared to unprophylaxed cohorts (Fig 2C). Moreover, anti-DLL4 mAb prophylaxis was associated with an improved regulatory T cell/conventional T cell ratio in the colon but not in liver (Fig 2D). Collectively, our results show that the function of individual Notch ligands is preserved from mice to primates in aGVHD. We provide the first demonstration of the important role of Notch signaling in alloimmune T cell activation in a large animal model of aGVHD, and the therapeutic potential of DLL4 blockade for aGVHD prevention. Disclosures Tkachev: Regeneron Pharmaceuticals, Inc.: Research Funding. Kuhnert:Regeneron Pharmaceuticals, Inc.: Employment. Blazar:Kadmon Corporation, LLC: Consultancy, Research Funding. Carpenter:Regeneron Pharmaceuticals, Inc.: Employment. Harari:Regeneron Pharmaceuticals, Inc.: Employment. Thurston:Regeneron Pharmaceuticals, Inc.: Employment, Equity Ownership. Kean:Regeneron Pharmaceuticals, Inc.: Research Funding.
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Duvic, Madeleine, Timothy M. Kuzel, Nam H. Dang, Miles Prince, Tatyana Feldman, Francine M. Foss, Matthew Guo, Lone Harild Ottesen, Chean Eng Ooi, and Youn H. Kim. "A Dose Finding Lead-in Study of E7777 (Diphtheria toxin fragment-Interleukin-2 Fusion Protein) in Persistent or Recurrent Cutaneous T-Cell Lymphoma (CTCL)." Blood 124, no. 21 (December 6, 2014): 3097. http://dx.doi.org/10.1182/blood.v124.21.3097.3097.
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Abstract Introduction: E7777 is a recombinant cytotoxic fusion protein composed of diphtheria toxin fragments A and B and human interleukin-2. E7777 has the same amino acid sequence as denileukin diftitox (DD) (approved as ONTAK in the USA for treatment of persistent or recurrent CTCL) but with improved purity and an increased percentage of active protein monomer species. This study is a pivotal multicenter open-label single-arm study comprising a Lead-In part (approx. 20 pts) to select the E7777 dose for the Main Study (70 patients [pts]) in which primary efficacy and safety of E7777 is assessed. Dose finding is necessary since the specific bioactivity of E7777 is 1.5 – 2 times that of the prior less purified form (ONTAK). The Lead-In study is reported in this abstract. Methods: A Continual Reassessment Method (CRM) is used for dose-finding with E7777 doses ranging from 3 – 18 µg/kg to be tested. The CRM is designed to target a DLT rate of approx. 20%. Inclusion criteria were patients ≥ 18 yr old, with a diagnosis of Mycosis Fungoides (MF) or Sézary Syndrome (SS) with stage I-IV disease at study entry, measurable CD25+ tumor, and who have received at least one prior therapy for CTCL. Prior commercial DD therapy was not allowed. E7777 was administered as monotherapy by iv infusion over 60 min on 5 consecutive days every cycle of 21 days. Pts were be dosed up to 8 cycles; additional dosing is allowed if deemed beneficial by the treating physician. Required premedication included an antihistamine, anti-pyretic, and anti-emetic; in case of infusion-related reaction low-dose systemic steroid premedication was allowed. The aim of the Lead–in study was to establish the maximum tolerated dose (MTD) and the recommended Main Study dose (based on the MTD and clinical judgment), and to assess safety and tumor response. Tumor responses were assessed according to the new ISCL/EORTC criteria (Olsen 2011). Results: Seventeen pts have been treated in the Lead-In. There were 8 males and 9 females, with median age 64 (range 26-81). Thirteen pts had MF (3, 7, 1, and 2 pts with Stage I, II, III, and IV disease, respectively) and 4 had SS (Stage IV). Fourteen or more pts had at least 4 lines of prior therapy. Pts were treated for a median of 4 cycles (range 1-8 cycles) and 8 patients are ongoing. Of the 9 pts who have discontinued from the study, 5 were for disease progression, 2 for AEs, 1 completed treatment per protocol, and 1 was pt choice. Pts were treated at doses ranging from 6 to 15 µg/kg; dose levels were assigned by the CRM based on the cumulative DLT information. The dose levels for each pt are shown in chronological order in the Table below, with the corresponding DLT assessments.TableContinual Reassessment MethodPatient #Dose (µg/kg)DLT16No29No312No415Yes56No6-129No13-1512No1615Yes1712No In the 17 patients treated, there were two DLTs; both occurred at the 15 µg/kg dose level and were capillary leak syndrome (CLS) (one Gr 2 with hospitalization, and one Gr 4). Based on preliminary results from these 17 pts, the highest dose with a DLT rate of ≤ 20% is 12 µg/kg. The most frequent AEs occurring in ≥ 3 pts were nausea (6 pts), ALT increased and AST increased (4 pts each), and vomiting, chills, fatigue, pyrexia, myalgia, rash, staph skin infection (3 pts each). Serious AEs considered related to study drug were CLS (2 pts) and pruritus, rash, diarrhea, vomiting, hypoxemia, and tumor flare (all in 1 pt each). AEs leading to drug discontinuation were CLS (2 pts). There were no deaths on study. Five pts achieved an objective response (OR) as assessed by the investigator, including 1 pt with relapse after allogeneic stem cell transplantation who received 8 courses and achieved a complete remission with associated skin graft-vs-host disease. These responses occurred at dose levels of 6, 9, and 12 µg/kg, including in 3 pts with stage IV disease (2 MF, 1 SS). Conclusion: Dose finding of E7777 in CTCL is proceeding with the CRM method. The toxicity profile is acceptable and so far no new safety signals compared to ONTAK has been identified. Initial signs of activity have been observed. Final data from this Lead-in study will be presented. Disclosures Duvic: Eisai Inc.: Member of safety monitoring committee for trial Other, Research Funding. Kuzel:Eisai Inc.: Research Funding. Dang:Eisai Inc.: Protocol Steering Committee Other, Research Funding. Prince:Eisai Inc.: Research Funding. Foss:Eisai Inc.: Consultancy. Guo:Eisai Inc.: Employment. Ottesen:Eisai: Employment. Ooi:Eisai Inc.: Employment. Kim:Eisai inc.: Protocol Steering Committee Other.
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Song, Hoyoung. "Park Un's ‘philosophy of self-cultivation’: Focusing on the System of Thought in 'Gyukmongpyeon'." Institute of Korean Cultural Studies Yeungnam University 84 (August 31, 2023): 305–36. http://dx.doi.org/10.15186/ikc.2023.8.31.10.
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This article examines the system of thought concerning Park Un's philosophy of self-cultivation, based on one of his two main works, Gyukmongpyeon.
Park Un was a representative scholar of Neo-Confucianism from the Gyeongbuk Seonsan region during the middle period of the Joseon Dynasty. He gained widespread recognition for his filial devotion to his parents. He studied under Park Young along with the Kim brothers, Kim Chwiseong and Kim Chwimun, contributing to the nationwide prominence of the Songdang school of thought. However, following the last wishes of his father, Park Jongwon, who had witnessed the tyrannical rule of King Yeonsan and the political chaos during King Jungjong's reign, he did not pursue a career in government. Instead, he stayed in his hometown, dedicated himself to scholarly pursuits, and worked to pass down his academic achievements to future generations. He also gained fame as a great scholar of his time through interactions and academic discussions with contemporary scholars like Lee Eonjeok and Lee Hwang.
At the age of 50 (in 1542), Park Un compiled Gyukmongpyeon by selecting various sayings from the Cheng-Zhu school of Confucianism centered around Cheng Yi and Zhu Xi, focusing on ‘Geo Gyeong Gung Ri’. ‘Geo Gyeong’ refers to a self-cultivation method that targets the heart-mind to foster virtue, while ‘Gung Ri’ refers to a study method targeting principles to explore all things and expand knowledge. These two elements collectively indicate the self-cultivation philosophy of the Cheng-Zhu school that needs to be integrated to prevent the human mind from falling into desire.
Lee Yulgok wrote in the postscript of Gyukmongpyeon: “Only after reading Master Park Un's Gyukmongpyeon did I realize how deep his research into the self-cultivation theory of the Cheng-Zhu school was, and how diligently he had studied. Had that not been the case, the sentences he selected could not have been so precise and heartfelt.
Although we can't meet t he v arious masters o f the C heng-Zhu s chool today, Park Un has gathered all their beneficial teachings left for future generations. The grace he has bestowed upon future scholars is indeed immense.” Through compiling Gyukmongpyeon, Park Un not only succinctly and clearly organized the self-cultivation philosophy of previous sages but also significantly contributed to the scholarly activities of future generations.
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Walker, Brian A., Shweta S. Chavan, Jie He, Ruslana Tytarenko, Shan Zhong, Shayu Deshpande, Purvi Patel, et al. "A Survey of Fusion Genes in Myeloma Identifies Kinase Domain Activation Which Could be Targeted with Available Treatments." Blood 128, no. 22 (December 2, 2016): 117. http://dx.doi.org/10.1182/blood.v128.22.117.117.
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Abstract Introduction Although fusion genes other than the immunoglobulin (Ig) translocation, t(4;14), which results in IGH-WHSC1fusions, are not frequently detected in multiple myeloma (MM), recent evidence suggests that kinase fusion gene fusions do occur relatively frequently and may inform on treatment algorithms. Here we use a hybrid-capture based, next-generation sequencing assay to survey fusion genes in patients with MM. Methods We report on 1421 samples from 958 individuals diagnosed with either monoclonal gammopathy of unknown significance (MGUS), smoldering multiple myeloma (SMM) or MM who underwent targeted sequencing with the FoundationOne Heme® (F1H) assay. Tumor samples were obtained from bone marrow aspirates, enriched by CD138+selection using magnetic beads (AutoMACs, Miltenyi Biotech, Cologne, Germany or RoboSep, StemCell Technologies, Vancouver, Canada). RNA and DNA were extracted using the AllPrep DNA/RNA mini kit (Qiagen, Hilden, Germany), RNeasy RNA extraction kit (Qiagen) or Puregene DNA extraction kit (Qiagen). ≥ 50 ng of extracted DNA or RNA was processed on the F1H assay. The current assay analyzes the complete coding DNA sequence of 405 genes, as well as selected introns of 31 genes involved in chromosomal rearrangements as well as the RNA sequence of 265 commonly rearranged genes resulting in gene fusions. Genes included in this assay encode known or likely targets of therapy, either approved or in clinical trials, or are otherwise known drivers of oncogenesis. Sequencing was to an average depth of 510x and was performed using the Illumina HiSeq 2500. Sequences were analyzed for selected gene rearrangements including fusion genes which were detected by a combination of DNA and RNA sequencing. Results Rearrangements into the Ig loci were detected and included the 5 main translocations: t(4;14), t(6;14), t(11;14), t(14;16), and t(14;20), as well as translocations involving MYC at 8q24. From a combination of DNA capture and RNA-seq expression values we used 107 samples in a training set with matching gene expression profiling data to determine cut-offs for FGFR3, WHSC1, CCND3, MAF, MAFB, CCND2 and CCND1to stratify patients into the 5 main translocation groups. We used these values to classify a further 391 samples with corresponding gene expression profiling (GEP) data, resulting in sensitivities and specificities of t(4;14), 98% and 100%; t(6;14), 100% and 99%; t(11;14), 99% and 95%; t(14;16), 77% and 100%; t(14;20), 100% and 100%, respectively. 40 non-Ig rearrangements were detected in 38 patients (4.2%), of which 21 in-frame fusion genes were predicted. Recurrent fusion-genes, identified in more than one patient, included EIF4E3-FOXP1, TXNDC5-MYC and SUB1-WHSC1. As well as TXNDC5, MYC was also partnered with FOXO3, both of which are known partners of the MYC translocation. 12 of the 21 in-frame fusion genes involved kinase domains, including fusions with BRAF (n=4), NTRK3 (n=2), ALK (n=1), ROS1 (n=1), MAPK14 (n=1), MAP3K14 (n=1), FGFR1 (n=1), and DLG2 (n=1). Fusions involving each of these genes have been documented in other cancers. BRAF fusions are thought to partner with genes encoding homodimerization domains, resulting in downstream activation of Ras signaling. Other kinase fusions result in receptor signaling and downstream activation of the Ras signaling pathway. Of the patients with kinase fusions, 2 had an activating KRAS, NRAS or BRAF mutation but only one was clonal (84% cancer clonal fraction). One patient with samples taken at different timepoints had a GTF2I-BRAF fusion and concomitant KRAS G13C mutation (16% allele frequency), both of which were not detectable 8 months later but an AGK-BRAF fusion was detected at that time suggesting clonal selection. Conclusion Non-Ig fusion genes are present in myeloma patients, but at a low frequency. Most of the fusions detected contained a kinase domain indicating activation of the Ras signaling pathway, which is also activated through KRAS, NRAS and BRAF mutations in 50% of patients. Although rare (1%), these kinase fusions are potential clinical targets in myeloma where kinase inhibitors, such as crizotinib, can be used which has shown to be effective against ALK and ROS1 fusions. Disclosures He: Foundation Medicine, Inc: Employment, Equity Ownership. Zhong:foundation medicine: Employment. Bailey:Foundation Medicine, Inc: Employment, Equity Ownership. Vergillo:Foundation Medicine, Inc: Employment. Ross:Foundation Medicine, Inc: Employment. Miller:Foundation Medicine: Employment, Equity Ownership. Stephens:Foundation Medicine: Employment, Equity Ownership. Mughal:Foundation Medicine: Employment, Equity Ownership. Davies:Celgene: Consultancy, Honoraria; Takeda: Consultancy, Honoraria; Janssen: Consultancy, Honoraria. Morgan:Janssen: Research Funding; Univ of AR for Medical Sciences: Employment; Celgene: Consultancy, Honoraria, Research Funding; Takeda: Consultancy, Honoraria; Bristol Meyers: Consultancy, Honoraria.
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Du, Xiaoru. "IDEO Product Development Case Analysis." BCP Business & Management 13 (November 16, 2021): 396–401. http://dx.doi.org/10.54691/bcpbm.v13i.116.
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IDEO is one of the successful product development companies, it established in 1991 and combined with 3 companies (David Kelley Design, ID Two and Matrix Product Design). As one of the world’s leading design firms, IDEO won a large number of awards than other product development firms. This company has a rapidly development in last several years, owned over 660 employees in the various disciplines. IDEO help organizations in the public and private sectors to find new design approach to innovate and grow, its major well-know clients are include Apple Inc., AT&T, Coca-Cola, Microsoft, Steelcase, PNC Financial Services and Palm. The company utilize design thinking as their main design process approach and focus on investigate and satisfied consumers’ needs.
Books on the topic "Chas. T. Main, Inc"
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Eryk, Czajkowski, ed. Hit man: Wyznania ekonomisty od brudnej roboty. Warszawa: Wydawnictwo Studio Emka, 2006.
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Antonio, Bravo Alfonso José, ed. Confesiones de un gángster económico. Barcelona: Ediciones Urano, 2009.
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John, Perkins. Confesiones de un gángster económico: La cara oculta del imperialismo americano. Barcelona: Ediciones Urano, 2005.
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John, Perkins. Ārthika ghātanayaku gē pāpōccāraṇaya. Koḷamba: Dēśa Hitaiṣi Jātika Vyāpāraya, 2008.
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New Confessions of an Economic Hit Man. Berrett-Koehler Publishers, Incorporated, 2016.
Find full textConference papers on the topic "Chas. T. Main, Inc"
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Cocco, Daniele, Fabio Serra, and Vittorio Tola. "Fixed-Bed Coal Gasifiers Integrated With MCFC-GT Hybrid Systems for Distributed Power and Heat Generation." In ASME Turbo Expo 2008: Power for Land, Sea, and Air. ASMEDC, 2008. http://dx.doi.org/10.1115/gt2008-50777.
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In this paper, a performance assessment of coal gasification processes integrated with molten carbonate fuel cells (IG-MCFC) is reported on. The main aim of the study was to evaluate the performance of small and medium size IG-MCFC systems based on fixed-bed gasifiers for distributed power and heat generation. In particular, the plant configuration considered here was developed on the basis of the 700 kg/h fixed-bed up-draft coal gasifier located in the Sotacarbo Research Centre in Carbonia, Italy. The MCFC section is based on the DFC/T® hybrid system developed by FCE Inc., and includes a MCFC stack integrated with an indirectly heated gas turbine. Two different coals, namely a low and a high sulphur coal, were considered. Moreover, the performance of MCFC hybrid systems fuelled by natural gas and coal gas were also compared. The results of the performance assessment show that the optimum value of the gas turbine pressure ratio is around 3, which is very similar to that used by the DFC/T systems proposed by FCE Inc. and fuelled by natural gas. However, replacing methane with coal gases leads to a significant decrease in MCFC efficiency, on the order of 10–11 percentage points. On the whole, the performance assessment carried out in this paper demonstrates that IG-MCFC systems could be an interesting option for small- and medium-size power generation plants fuelled by coal as they can reach efficiencies of nearly 40%.
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Xu, Fei, Tak-Ming Chan, and Ju Chen. "Punching Shear Mechanism Based Design of Concrete-Filled CHS T-Joints under In-Plane Bending." In 12th international conference on ‘Advances in Steel-Concrete Composite Structures’ - ASCCS 2018. Valencia: Universitat Politècnica València, 2018. http://dx.doi.org/10.4995/asccs2018.2018.7513.
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The in-plane bending behaviour of concrete-filled circular hollow section (CHS) T-joints was examined in this paper. The main failure mode, the punching shear of the chord-wall, was observed from the test of four large-scale joints with the diameter ratio of brace to chord (β) ranging from 0.44 to 0.85. The tube-wall deformation was measured to assess the governing failure mode of the composite joints. Complementary finite element (FE) methodology was verified against the experimental findings and the validated FE models were used to further investigate the mechanical behaviour and the design methodology. The feasibility to apply a fracture criterion in the material-level to a large-scale structural simulation was evaluated. The validated FE modes could successfully capture the tube-wall fracture initiation and propagation. Based on both experimental and numerical investigations, it was shown that the capacity of composite joints was governed by the ultimate strength limit, i.e. punching shear strength, due to the infill concrete that mitigated both inward and outward deformation on the compressive and tensile sides, respectively. The analytical model was established to reveal the composite actions between the tube and the inner concrete, and to elaborate the development of the flexural section-resistance. Finally, the design equation was proposed and could well predict the moment capacity.
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Ding, Wowo, Yihui Yang, Wei You, and Yunlong Peng. "Morphological analysis: to evaluate the pattern of Residential building based on wind performance." In 24th ISUF 2017 - City and Territory in the Globalization Age. Valencia: Universitat Politècnica València, 2017. http://dx.doi.org/10.4995/isuf2017.2017.5977.
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Yihui Yang, Wei You, Yunlong Peng, Wowo Ding*, School of Architecture and Urban Planning, Nanjing University, No.22 Hankou Rd, Jiangsu 210093, P.R.China. E-mail:yi_hui_yang@outlook.com, youwei@nju.edu.cn, 249626020@qq.com, dww@nju.edu.cn,Phone number:15850561165, 13852293251, +86 25 83593020, Keyword: Residential plot, Apartment pattern, performance evaluation, wind environment Conference topics and scale: Tools of analysis in urban morphology Residential morphological patterns are reflection of people's living habits and tradition, local climate and building regulations, so that one of those factors could be studied through in order to understand residential morphological patterns. Based upon our previous study, we do know that in China living habits and local climate mainly influence the shape of residential buildings and apartment patterns, but we do not know whether the pattern of residential plots determined by FAR and sunshine hours are suitable for wind environment related to residential environmental quality. Therefore, it is very significant to evaluate wind environment within residential plots based on the apartment pattern controlled by various building codes. Our study focuses on the pattern of Slab apartments in Nanjing, which are mainly used in China, and selects 40 residential slices with different plot shapes, plot FAR, building heights and sizes. Based upon MATLAB, we have got all geometrical data between buildings among these slices to identify the spatial pattern character of each residential plot. Through evaluating wind environment of these slices by simulation we can obtain wind speed, pressure and age of air and choose the pattern of age of air as the main evaluation factor of wind performance. Correlation analysis will be made between the apartment patterns and pattern of age of air, by doing so, each typical space between buildings will be evaluated. Our study will reveal the relevance of apartment pattern and wind environment, which can be used to support and improve design in the future. References（95 words） Oke. T. R (1988) ‘Street Design and Urban Canopy Layer Climate’, Energy and Buildings11, 103-113. Wowo Ding, Youpei Hu, Pingping Dou (2012) ‘Study on Interrelationship between Urban Pattern and Urban Microclimate’, Architectural Journal 527, 16-21. Edward Ng, Chao Yuan, Liang Chen, Chao Ren, Jimmy C.H. Fung (2011) ‘Improving the wind environment in high-density cities by understanding urban morphology and surface roughness: A study in Hong Kong’, Landscape and Urban Planning101, 59-74. Youpei Hu (2014) ‘A Performance-Oriented Study on the Morphological Optimization in a High Density Area Concerning Urban Heat Island Effect’, Architectural Journal 557, 23-29. *corresponding author
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Stoica, Marius, and Bogdan Gozu. "ORIGINAL ASPECTS REGARDING THE PSYCHOMOTOR EVALUATION OF THE PRIMARY SCHOOL STUDENTS." In eLSE 2013. Carol I National Defence University Publishing House, 2013. http://dx.doi.org/10.12753/2066-026x-13-241.
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Problem Statement. The study of the main factors specific to the psychomotor phenomenon (in this case, aspects related to manual dexterity and bilateral coordination), as well as of the connections between those factors in relation to the subjects' chronological age. Purpose. Our experiment envisages an analysis of the connection between motor proficiency age and chronological age in primary school students, based on the information provided by the Bruininks-Oseretsky Test - Second Edition (BOT-2) applied for the first time in Romania. Methods. Forty subjects were selected to participate in this research experiment (20 boys and 20 girls), 1st up to 4th grade students, coming from urban and rural areas alike. The subjects' evaluation took place from March 20, 2010 until June 4, 2010 and consisted in the application of 12 test items specific to manual dexterity and bilateral coordination subtests provided by the Bruininks-Oseretsky Test, Second Edition. In terms of computer software and specific tools used for statistical analysis of the obtained data, the following instruments were used: BOT-2 ASSISTTM, Scoring and Reporting System (integrated software of the Bruininks-Oseretsky Test - Second Edition), MINITAB 15.1 of MINITAB Inc. and MICROSOFT EXCEL 2003. Results and discussions. The tests revealed that with respect to manual dexterity, the average motor proficiency age (10 years and 5 months) was higher by 1 year and 2 months than the average chronological age of the tested subjects (9 years and 3 months), while the verification of the statistical hypothesis through the dependent T-Test revealed a statistically significant difference of means (P=0.009 is smaller than 0.05). Regarding the bilateral coordination subtest, the average motor proficiency age (8 years and 7 months) is lower by 8 months than the average chronological age (9 years and 3 months), and in this case the verification of the statistical hypothesis performed through the same test, revealed a statistically significant difference of means as well (P=0.019 is smaller than 0.05). Conclusions. The analysis of the results obtained by the tested subjects allows us to confirm the research hypothesis regarding the manual dexterity and bilateral coordination subtests. We can conclude as well that the use of the Bruininks-Oseretsky Test - Second Edition, for the first time in Romania, within an experimental research, represents, besides an original approach, a major opportunity of obtaining extremely valuable data regarding several psychomotor characteristics of primary school students.
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Naknaka, Manchukarn, Trinh Dinh Phu, Khamawat Siritheerasas, Pattarapong Prasongtham, Feras Abu-Jafar, Ali Abbasgolipour, and Pham Nam Hieu. "ERD Drilling Record Achieved in the Gulf of Thailand with an Outstanding Drilling Efficiency." In International Petroleum Technology Conference. IPTC, 2021. http://dx.doi.org/10.2523/iptc-21488-ms.
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Abstract The objective of this research is to describe the methodology used to drill the most extended reach well (ERD) in the Gulf of Thailand. The Jasmine field is a mature, sophisticated, oil field with many shallow reservoir targets that require a minimum 10,000ft horizontal displacement. As such, the main challenges faced, and the novel technology applied is described in detail by this research. The research is an example of successfully drilling a challenging well, safely and efficiently. The Jasmine C – Well X, is a 3-string design structure with an 11-3/4in top hole, an 8-1/2in intermediate section, and a 6-1/8in reservoir horizontal section. Well X was constructed by utilizing an existing platform well slot. The challenge involved drilling from the top hole to the kickoff point and directional drilling away from the casing stump of the existing well to avoid any collision with nearby wells emanating from the Jasmine C platform. The 8-1/2in hole section was the most important segment as it had to reach the landing point precisely in order to start the 6-1/8in section for GeoSteering in the reservoir section. The 8-1/2in section encountered three challenges that could affect drilling efficiency.Directional Drilling – The complexities of the well profile:The method involved making well inclination (INC) lower than 82deg in the tangent interval in order to reduce the well's tortuosity as much as possible.Hole condition – Hole cleaning and fluid losses control:The method involved the use of Low Toxicity Oil Based Mud (LTOBM) CaCO3 system, the chemical elements in the drilling fluid system could help to seal the high permeable zones.Drilling Engineering – Torque and Drag (T&D) control:The method taked into account the 7in casing run to the bottom of the hole, which the casing driven system did not allow for rotation The well was completed successfully without any additional trips. A Total Depth (TD) was of 13,052ftMD was achieved to reach reservoirs at 3,260ft TVDSS. It was therefore announced in 2019 as a new ERD record for Mubadala Thailand (ERD ratio = 3.26, Directional Difficulty Index (DDI) = 6.95). The top hole and 9-5/8in casing were set in the right depth. An 8-1/2in section was accomplished on the planned trajectory with an average on bottom Rate of Penetration (ROP) at 319 ft/hr. The 6-1/8in section was drilled by geosteering to achieve sub-surface objectives. A total of 2,143ft intervals inside the reservoir was successfully achieved. While drilling, lost circulation events occured, but the mud system was conditioned with Lost Circulation Materials (LCM). Therefore, drilling performance was unaffected. Moreover, the Bit's Total Flow Area (TFA) and Rotary steering systems (RSS) flow restrictor was configured to allow directional drilling at a very low Flow rate of 470gpm. Addition, 30 joints of 5-1/2in Heavy Weight Drill Pipe (HWDP) and 39 joints of 4in HWDP were added into the Bottom Hole Assembly (BHA) to transfer string weight to drill bitsand drill to well TD. As complexities of the well profile were fully aware, the casing was runned and minimized the open hole friction until the casing was deployed successfully. In the Gulf of Thailand, drilling the longest ERD well in a shallow True Vertical Depth (TVD) was clearly groundbreaking and entailed the successful management of the key operational challenges related to identification, job planning, design, technology selection, and implementation. This research illuminates the challenges and technical solutions of long ERD well and serves as an example of what can be achieved in the region and globally.