Academic literature on the topic 'Checkpoint'

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Journal articles on the topic "Checkpoint"

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PAUN, MIHAELA, NICHAMON NAKSINEHABOON, RAJA NASSAR, CHOKCHAI LEANGSUKSUN, STEPHEN L. SCOTT, and NARATE TAERAT. "INCREMENTAL CHECKPOINT SCHEMES FOR WEIBULL FAILURE DISTRIBUTION." International Journal of Foundations of Computer Science 21, no. 03 (2010): 329–44. http://dx.doi.org/10.1142/s0129054110007283.

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Incremental checkpoint mechanism was introduced to reduce high checkpoint overhead of regular (full) checkpointing, especially in high-performance computing systems. To gain an extra advantage from the incremental checkpoint technique, we propose an optimal checkpoint frequency function that globally minimizes the expected wasted time of the incremental checkpoint mechanism. Also, the re-computing time coefficient used to approximate the re-computing time is derived. Moreover, to reduce the complexity in the recovery state, full checkpoints are performed from time to time. In this paper we pre
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Rhind, Nicholas, and Paul Russell. "The Schizosaccharomyces pombe S-Phase Checkpoint Differentiates Between Different Types of DNA Damage." Genetics 149, no. 4 (1998): 1729–37. http://dx.doi.org/10.1093/genetics/149.4.1729.

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Abstract We have identified an S-phase DNA damage checkpoint in Schizosaccharomyces pombe. This checkpoint is dependent on Rad3, the S. pombe homolog of the mammalian ATM/ATR checkpoint proteins, and Cds1. Cds1 had previously been believed to be involved only in the replication checkpoint. The requirement of Cds1 in the DNA damage checkpoint suggests that Cds1 may be a general target of S-phase checkpoints. Unlike other checkpoints, the S. pombe S-phase DNA damage checkpoint discriminates between different types of damage. UV-irradiation, which causes base modification that can be repaired dur
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Naksinehaboon, Nichamon, Mihaela P[un, Raja Nassar, Chokchai Box Leangsuksun, and Stephen Scott. "High Performance Computing Systems with Various Checkpointing Schemes." International Journal of Computers Communications & Control 4, no. 4 (2009): 386. http://dx.doi.org/10.15837/ijccc.2009.4.2455.

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Finding the failure rate of a system is a crucial step in high performance computing systems analysis. To deal with this problem, a fault tolerant mechanism, called checkpoint/ restart technique, was introduced. However, there are additional costs to perform this mechanism. Thus, we propose two models for different schemes (full and incremental checkpoint schemes). The models which are based on the reliability of the system are used to determine the checkpoint placements. Both proposed models consider a balance of between checkpoint overhead and the re-computing time. Due to the extra costs fr
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Rhind, Nicholas, and Paul Russell. "Roles of the Mitotic Inhibitors Wee1 and Mik1 in the G2 DNA Damage and Replication Checkpoints." Molecular and Cellular Biology 21, no. 5 (2001): 1499–508. http://dx.doi.org/10.1128/mcb.21.5.1499-1508.2001.

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ABSTRACT The G2 DNA damage and DNA replication checkpoints in many organisms act through the inhibitory phosphorylation of Cdc2 on tyrosine-15. This phosphorylation is catalyzed by the Wee1/Mik1 family of kinases. However, the in vivo role of these kinases in checkpoint regulation has been unclear. We show that, in the fission yeastSchizosaccharomyces pombe, Mik1 is a target of both checkpoints and that the regulation of Mik1 is, on its own, sufficient to delay mitosis in response to the checkpoints. Mik1 appears to have two roles in the DNA damage checkpoint; one in the establishment of the c
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Garber, Peter M., and Jasper Rine. "Overlapping Roles of the Spindle Assembly and DNA Damage Checkpoints in the Cell-Cycle Response to Altered Chromosomes in Saccharomyces cerevisiae." Genetics 161, no. 2 (2002): 521–34. http://dx.doi.org/10.1093/genetics/161.2.521.

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Abstract The MAD2-dependent spindle checkpoint blocks anaphase until all chromosomes have achieved successful bipolar attachment to the mitotic spindle. The DNA damage and DNA replication checkpoints block anaphase in response to DNA lesions that may include single-stranded DNA and stalled replication forks. Many of the same conditions that activate the DNA damage and DNA replication checkpoints also activated the spindle checkpoint. The mad2Δ mutation partially relieved the arrest responses of cells to mutations affecting the replication proteins Mcm3p and Pol1p. Thus a previously unrecognize
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Yamada, Ayumi, Brad Duffy, Jennifer A. Perry, and Sally Kornbluth. "DNA replication checkpoint control of Wee1 stability by vertebrate Hsl7." Journal of Cell Biology 167, no. 5 (2004): 841–49. http://dx.doi.org/10.1083/jcb.200406048.

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G2/M checkpoints prevent mitotic entry upon DNA damage or replication inhibition by targeting the Cdc2 regulators Cdc25 and Wee1. Although Wee1 protein stability is regulated by DNA-responsive checkpoints, the vertebrate pathways controlling Wee1 degradation have not been elucidated. In budding yeast, stability of the Wee1 homologue, Swe1, is controlled by a regulatory module consisting of the proteins Hsl1 and Hsl7 (histone synthetic lethal 1 and 7), which are targeted by the morphogenesis checkpoint to prevent Swe1 degradation when budding is inhibited. We report here the identification of X
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Kumar, Parveen, and Rachit Garg. "Soft-Checkpointing Based Hybrid Synchronous Checkpointing Protocol for Mobile Distributed Systems." International Journal of Distributed Systems and Technologies 2, no. 1 (2011): 1–13. http://dx.doi.org/10.4018/jdst.2011010101.

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Minimum-process coordinated checkpointing is a suitable approach to introduce fault tolerance in mobile distributed systems transparently. In order to balance the checkpointing overhead and the loss of computation on recovery, the authors propose a hybrid checkpointing algorithm, wherein an all-process coordinated checkpoint is taken after the execution of minimum-process coordinated checkpointing algorithm for a fixed number of times. In coordinated checkpointing, if a single process fails to take its checkpoint; all the checkpointing effort goes waste, because, each process has to abort its
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Islam, Tanzima Zerin, Kathryn Mohror, Saurabh Bagchi, Adam Moody, Bronis R. de Supinski, and Rudolf Eigenmann. "McrEngine: A Scalable Checkpointing System Using Data-Aware Aggregation and Compression." Scientific Programming 21, no. 3-4 (2013): 149–63. http://dx.doi.org/10.1155/2013/341672.

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High performance computing (HPC) systems use checkpoint-restart to tolerate failures. Typically, applications store their states in checkpoints on a parallel file system (PFS). As applications scale up, checkpoint-restart incurs high overheads due to contention for PFS resources. The high overheads force large-scale applications to reduce checkpoint frequency, which means more compute time is lost in the event of failure. We alleviate this problem through a scalable checkpoint-restart system, mcrEngine. McrEngine aggregates checkpoints from multiple application processes with knowledge of the
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Qiu, Ling, Andrew Burgess, David P. Fairlie, Helen Leonard, Peter G. Parsons, and Brian G. Gabrielli. "Histone Deacetylase Inhibitors Trigger a G2 Checkpoint in Normal Cells That Is Defective in Tumor Cells." Molecular Biology of the Cell 11, no. 6 (2000): 2069–83. http://dx.doi.org/10.1091/mbc.11.6.2069.

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Important aspects of cell cycle regulation are the checkpoints, which respond to a variety of cellular stresses to inhibit cell cycle progression and act as protective mechanisms to ensure genomic integrity. An increasing number of tumor suppressors are being demonstrated to have roles in checkpoint mechanisms, implying that checkpoint dysfunction is likely to be a common feature of cancers. Here we report that histone deacetylase inhibitors, in particular azelaic bishydroxamic acid, triggers a G2 phase cell cycle checkpoint response in normal human cells, and this checkpoint is defective in a
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Soni, Aashish, Xiaolu Duan, Martin Stuschke, and George Iliakis. "ATR Contributes More Than ATM in Intra-S-Phase Checkpoint Activation after IR, and DNA-PKcs Facilitates Recovery: Evidence for Modular Integration of ATM/ATR/DNA-PKcs Functions." International Journal of Molecular Sciences 23, no. 14 (2022): 7506. http://dx.doi.org/10.3390/ijms23147506.

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The intra-S-phase checkpoint was among the first reported cell cycle checkpoints in mammalian cells. It transiently slows down the rate of DNA replication after DNA damage to facilitate repair and thus prevents genomic instability. The ionizing radiation (IR)-induced intra-S-phase checkpoint in mammalian cells is thought to be mainly dependent upon the kinase activity of ATM. Defects in the intra-S-phase checkpoint result in radio-resistant DNA synthesis (RDS), which promotes genomic instability. ATM belongs to the PI3K kinase family along with ATR and DNA-PKcs. ATR has been shown to be the ke
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Dissertations / Theses on the topic "Checkpoint"

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Ho, Chui Chui. "Characterization of the regulation of p53 and checkpoint kinases in DNA integrity checkpoints /." View abstract or full-text, 2006. http://library.ust.hk/cgi/db/thesis.pl?BICH%202006%20HO.

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Liang, Hongqing. "Quantitative analysis of interactions between cell cycle kinases and checkpoint pathways during checkpoint recovery." Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.607913.

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Wang, Kexi. "Silencing of the Mitotic Checkpoint." University of Toledo / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1410369908.

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Ji, Wenbin. "Regulation of the Mitotic Checkpoint." University of Toledo / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1484174079006341.

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Smoler, Gunilla Kanter. "Functional characterization of conserved checkpoint genes." Göteborg, Sweden : Dept. of Cellular and Molecular Biology, Göteborg University, 1998. http://books.google.com/books?id=vM5qAAAAMAAJ.

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Mirchenko, L. "Mitotic checkpoint inactivation at anaphase onset." Thesis, University College London (University of London), 2011. http://discovery.ucl.ac.uk/1302282/.

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The mitotic checkpoint prevents chromosome segregation until all chromosomes have reached bi-polar orientation and come under tension on the mitotic spindle. Once this is achieved, the protease separase is activated to cleave the chromosomal cohesin complex and trigger anaphase. Cohesin cleavage releases tension between sister chromatids, however the mitotic checkpoint fails to respond to this apparent tension defect. The aim of this study was to understand why the mitotic checkpoint remains silent when sisters lose tension due to cohesin cleavage in anaphase. We showed in budding yeast that l
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Kanter, Smoler Gunilla. "Functional characterisation of conserved checkpoint genes." Göteborg : [s.n.], 1998. http://catalog.hathitrust.org/api/volumes/oclc/45150869.html.

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Yuan, Ivan. "Generation of synthetic spindle checkpoint signals." Thesis, University of Edinburgh, 2016. http://hdl.handle.net/1842/22030.

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The spindle checkpoint ensures proper chromosome segregation by monitoring kinetochore-microtubule interactions: unattached kinetochores recruit checkpoint proteins that combine to form a diffusible inhibitor which delays anaphase, thus buying cells time to fix attachment errors. Although the major checkpoint proteins were identified some 25 years ago, we have only just begun to understand how they assemble at unattached kinetochores to generate the crucial checkpoint signal. Much of this can be attributed to the difficulty associated with studying these proteins at the kinetochores, which are
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On, Kin Fan. "The role of MAD2L1BP in the silencing of the spindle-assembly checkpoint and the DNA damage checkpoint /." View abstract or full-text, 2009. http://library.ust.hk/cgi/db/thesis.pl?BICH%202009%20ON.

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Weirich, Alexandra. "Initiating the Spindle Assembly Checkpoint Signal: Checkpoint Protein Mad1 Associates with Outer Kinetochore Protein Ndc80 in Budding Yeast." Thèse, Université d'Ottawa / University of Ottawa, 2013. http://hdl.handle.net/10393/24248.

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The spindle assembly checkpoint (SAC) is an evolutionarily conserved mechanism that delays the initiation of anaphase by inhibiting the Anaphase Promoting Complex (APC) until all kinetochores have achieved bipolar attachment on the mitotic spindle. Mad1-3, Bub1, and Bub3, components of the SAC, are conserved from yeast to humans. These proteins localize to unattached kinetochores, though it is unknown with which kinetochore proteins they interact and how these interactions transduce information about microtubule attachement. Here, purification of the checkpoint proteins from Saccharomyces ce
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Books on the topic "Checkpoint"

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Šimičić, Darko. Checkpoint. Soros Centar zu Suvremenu Umjetnost, 1995.

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Baker, Nicholson. Checkpoint. Knopf Doubleday Publishing Group, 2004.

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Baker, Nicholson. Checkpoint. Alfred A. Knopf, 2004.

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Gladstone, Eve. Checkpoint. Harlequin, 1986.

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Mondadori, ed. Checkpoint. Mondadori, 2004.

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Chartered Institute of Management Accountants. and Accountancy Tuition Centre, eds. CIMA checkpoint. ATC Foulks Lynch, 1993.

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Chukwu, Onyema. Police checkpoint. West and Solomon Pub. Coy, 1997.

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Wägeus, Mats. Checkpoint: Roman. Bonnier Alba, 1994.

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Chartered Institute of Management Accountants. and Accountancy Tuition Centre, eds. CIMA checkpoint. ATC Foulks Lynch, 1993.

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Chartered Institute of Management Accountants. and Accountancy Tuition Centre, eds. CIMA checkpoint. ATC Foulks Lynch, 1993.

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Book chapters on the topic "Checkpoint"

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Gupta, Dipankar. "Urban Planning for “Citizens”: Emphasising Space Over Non-Space." In Checkpoint Sociology. Routledge, 2023. http://dx.doi.org/10.4324/9781003406204-6.

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Gupta, Dipankar. "Numerical Thresholds as Industrial Inhibitors: Raising Capacity and Formalizing the Economy." In Checkpoint Sociology. Routledge, 2023. http://dx.doi.org/10.4324/9781003406204-2.

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Gupta, Dipankar. "Normalising Caste: Same Numbers, Differing Relations." In Checkpoint Sociology. Routledge, 2023. http://dx.doi.org/10.4324/9781003406204-4.

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Gupta, Dipankar. "Smell Check Your Numbers: Public Policy and Sociological Sensitivity." In Checkpoint Sociology. Routledge, 2023. http://dx.doi.org/10.4324/9781003406204-1.

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Gupta, Dipankar. "Checkpoint Sociology: Three Theses on Method." In Checkpoint Sociology. Routledge, 2023. http://dx.doi.org/10.4324/9781003406204-13.

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Gupta, Dipankar. "Culture War Won: Defying Arithmetic in 2019 Elections." In Checkpoint Sociology. Routledge, 2023. http://dx.doi.org/10.4324/9781003406204-11.

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Gupta, Dipankar. "Beyond Numbers to Citizenship: Overcoming the Majority-Minority Divide." In Checkpoint Sociology. Routledge, 2023. http://dx.doi.org/10.4324/9781003406204-5.

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Gupta, Dipankar. "The Changing Villager: What the Numbers Do Not Tell." In Checkpoint Sociology. Routledge, 2023. http://dx.doi.org/10.4324/9781003406204-3.

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Gupta, Dipankar. "Source Credibility and Campaign Redundancy: The Merits of Slow Thinking." In Checkpoint Sociology. Routledge, 2023. http://dx.doi.org/10.4324/9781003406204-9.

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Gupta, Dipankar. "Why Other People Matter: Empathy and its Policy Implications." In Checkpoint Sociology. Routledge, 2023. http://dx.doi.org/10.4324/9781003406204-12.

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Conference papers on the topic "Checkpoint"

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Gao, Yingbo, Christian Herold, Zijian Yang, and Hermann Ney. "Revisiting Checkpoint Averaging for Neural Machine Translation." In Findings of the Association for Computational Linguistics: AACL-IJCNLP 2022. Association for Computational Linguistics, 2022. http://dx.doi.org/10.18653/v1/2022.findings-aacl.18.

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Huang, Xin, Wubiao Xu, Shiman Meng, et al. "Scrutinizing Variables for Checkpoint Using Automatic Differentiation." In SC24-W: Workshops of the International Conference for High Performance Computing, Networking, Storage and Analysis. IEEE, 2024. https://doi.org/10.1109/scw63240.2024.00056.

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Ravi, Divya, Veronica C. Torres, and Kimberley S. Samkoe. "Multi-spectral Paired-agent Imaging for Detection of Available Immune Checkpoint Proteins in Tumor Cells." In Clinical and Translational Biophotonics. Optica Publishing Group, 2025. https://doi.org/10.1364/translational.2025.ttu1f.4.

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Multi-spectral paired-agent imaging quantifies available PD-L1, PD-1, and CD80 receptor concentrations in lymphoma-mimicking phantoms. Dynamic measurements of PD-L1, PD-1, and CD80 can serve as a promising biomarker of PD-1 checkpoint inhibitor response.
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Garcia, Islene C., and Luiz E. Buzato. "Using Common Knowledge to Improve Fixed-Dependency-After-Send." In Workshop de Testes e Tolerância a Falhas. Sociedade Brasileira de Computação - SBC, 2000. http://dx.doi.org/10.5753/wtf.2000.23468.

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Checkpoint patterns that enforce the rollbak-dependency trackability (RDT) property allow effcient solutions to the determination of consistent global checkpoints that include a given set of checkpoints. Fixed-Dependency-After-Send (FDAS) is a well-known RDT protocol that forces the dependency vector of a process to remain unchanged during a checkpoint interval after the first message-send event. In this paper, we explore processes' common knowledge about their behavior to derive a more effcient condition to induce checkpoints under FDAS. We consider that our approach can be used to improve ot
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Sakata, Tiemi C., Islene C. Garcia, and Luiz E. Buzato. "Uso de Broadcast na Sincronização de Checkpoints em Protocolos Minimais." In Workshop de Testes e Tolerância a Falhas. Sociedade Brasileira de Computação - SBC, 2004. http://dx.doi.org/10.5753/wtf.2004.23387.

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Nos protocolos de checkpointing síncronos, a aplicação pode ser facilmente restabelecida após a ocorrência de uma falha, pois basta que todos os processos retornem ao seu último checkpoint salvo. Neste artigo, exploramos a classe de protocolos síncronos minimais na qual um número minimal de processos salva checkpoints a cada invocação do protocolo para a construção de um checkpoint global consistente. Cao e Singhal propuseram uma nova abordagem para desenvolver um protocolo minimal que utiliza broadcast para bloquear todos os processos e centralizar a um único processo a tarefa de determinar q
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Goulart, Henrique, Álvaro Franco, and Odorico Mendizabal. "Checkpointing Techniques in Distributed Systems: A Synopsis of Diverse Strategies Over the Last Decades." In Workshop de Testes e Tolerância a Falhas. Sociedade Brasileira de Computação - SBC, 2023. http://dx.doi.org/10.5753/wtf.2023.785.

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This paper concisely reviews checkpointing techniques in distributed systems, focusing on various aspects such as coordinated and uncoordinated checkpointing, incremental checkpoints, fuzzy checkpoints, adaptive checkpoint intervals, and kernel-based and user-space checkpoints. The review highlights interesting points, outlines how each checkpoint approach works, and discusses their advantages and drawbacks. It also provides a brief overview of the adoption of checkpoints in different contexts in distributed computing, including Database Management Systems (DBMS), State Machine Replication (SM
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Cardoso, Paulo Vinicus, Rhauani Weber Aita Fazul, and Patrícia Pitthan Barcelos. "Validação de Políticas para o Estabelecimento Dinâmico de Checkpoints no Apache Spark." In Simpósio Brasileiro de Redes de Computadores e Sistemas Distribuídos. Sociedade Brasileira de Computação, 2020. http://dx.doi.org/10.5753/sbrc.2020.12271.

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O Apache Spark é uma plataforma voltada ao processamento distribuído de dados em memória. Para uma persistência confiável e tolerante a falhas, o Spark usa a técnica de checkpoint. O estabelecimento de checkpoints, entretanto, precisa ser realizado manualmente através do código-fonte, o que dificulta uma configuração eficiente. Esse trabalho apresenta e valida uma arquitetura de configuração dinâmica para checkpoints no Spark. A arquitetura proposta inicia procedimentos de checkpoint automaticamente, com base em políticas de monitoramento que observam o sistema e suas aplicações. Os experiment
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Cardoso, Paulo Vinicius, and Patricia Pitthan Barcelos. "Impacto do Custo de Salvamento e dos Atributos de Configuração no Checkpoint do Apache Hadoop." In XXXVII Simpósio Brasileiro de Redes de Computadores e Sistemas Distribuídos. Sociedade Brasileira de Computação - SBC, 2019. http://dx.doi.org/10.5753/sbrc.2019.7384.

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O framework Apache Hadoop, usado para processar e armazenar grandes quantidades de dados, usa a técnica de Checkpoint and Recovery para auxiliar em recuperações pós-falha de seu sistema de arquivos distribuído. Porém, adaptações eficientes para período entre checkpoints do Hadoop dependem de observações apuradas do sistema. O objetivo deste trabalho é estimar o custo da realização de checkpoints e o tempo médio entre falhas do sistema a partir de um histórico de observações. Os fatores são observados e analisados com relação a diferentes variações de configuração do framework e do benchmark us
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Pintor, Erick, and Fernando Luís Dotti. "SMaRtTrie: Reducing Checkpoint’s Impact in SMR Systems with a CTrie Data Structure." In Simpósio Brasileiro de Redes de Computadores e Sistemas Distribuídos. Sociedade Brasileira de Computação - SBC, 2021. http://dx.doi.org/10.5753/sbrc.2021.16751.

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State Machine Replication (SMR) is a well-established approach for the development of fault tolerant systems through replication. Durable SMR systems rely on command logging and checkpoints for fast recovery upon failures. However, checkpoints are known to impact service's throughput as traditional SMR architectures stop serving requests in order to ensure checkpoint consistency. In this paper, we present SMaRtTrie: a simple in-memory key-value storage built on a concurrent trie data structure that supports the creation of consistent checkpoints in parallel with command execution. Exp
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Sababha, Belal H., and Osamah A. Rawashdeh. "Evaluation of Communication Induced Checkpointing in Resource Constrained Embedded Systems." In ASME 2011 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. ASMEDC, 2011. http://dx.doi.org/10.1115/detc2011-48634.

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Reconfiguration-Based Fault-Tolerance is one approach for developing dependable safety-critical embedded applications. This approach, compared to traditional hardware and software redundancy, is a promising technique that may achieve the required dependability with a significant reduction in cost in terms of size, weight, price, and power consumption. Reconfiguration necessitates using proper checkpointing protocols to support state reservation and task migration. One of the most common approaches is to use Communication Induced Checkpointing (CIC) protocols, which are well developed and under
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Reports on the topic "Checkpoint"

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Britt, Anne. G2 Checkpoint Responses in Arabidopsis. Office of Scientific and Technical Information (OSTI), 2013. http://dx.doi.org/10.2172/1116357.

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Duell, Jason, Paul H. Hargrove, and Eric S. Roman. Requirements for Linux Checkpoint/Restart. Office of Scientific and Technical Information (OSTI), 2002. http://dx.doi.org/10.2172/793773.

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Long, Junsheng, W. K. Fuchs, and Jacob A. Abraham. Compiler-Assisted Static Checkpoint Insertion. Defense Technical Information Center, 1992. http://dx.doi.org/10.21236/ada256039.

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Long, Junsheng, W. K. Fuchs, and Jacob A. Abraham. Compiler-Assisted Static Checkpoint Insertion. Defense Technical Information Center, 1991. http://dx.doi.org/10.21236/ada246496.

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Stern, David F. Mammalian Homologs of Yeast Checkpoint Genes. Defense Technical Information Center, 2001. http://dx.doi.org/10.21236/ada404591.

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Crocker, D., N. Freed, and A. Cargille. SMTP Service Extension for Checkpoint/Restart. RFC Editor, 1995. http://dx.doi.org/10.17487/rfc1845.

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Loncaric, Josip. Checkpoint-Restart and Platform Design Criteria. Office of Scientific and Technical Information (OSTI), 2019. http://dx.doi.org/10.2172/1544642.

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Stern, David. Mammalian Homologs of Yeast Checkpoint Genes. Defense Technical Information Center, 2000. http://dx.doi.org/10.21236/ada393426.

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Stern, David F. Mammalian Homologs of Yeast Checkpoint Genes. Defense Technical Information Center, 1999. http://dx.doi.org/10.21236/ada384149.

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Scott, Kenneth L., and Sharon E. Plon. Alternative DNA Damage Checkpoint Pathways in Eukaryotes. Defense Technical Information Center, 2001. http://dx.doi.org/10.21236/ada396714.

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