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Dissertations / Theses on the topic 'Checkpoints'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

Ho, Chui Chui. "Characterization of the regulation of p53 and checkpoint kinases in DNA integrity checkpoints /." View abstract or full-text, 2006. http://library.ust.hk/cgi/db/thesis.pl?BICH%202006%20HO.

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2

Fialho, de Queiroz Leonardo. "Fault Tolerance Configuration for Uncoordinated Checkpoints." Doctoral thesis, Universitat Autònoma de Barcelona, 2011. http://hdl.handle.net/10803/79095.

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La tendencia general de los computadores paralelos es crecer en complejidad y en número de componentes. La miniaturización y la concentración de dichos elementos es la principal causa de la aparición y aumento de los fallos en estos computadores. Asimismo, para permitir la ejecución correcta de las aplicaciones paralelas, existe la necesidad de proveer soporte y de tolerar fallos en estos entornos. Una estrategia amplamente utilizada es el rollback-recovery, que consiste en guardar periódicamente el estado de la aplicación y, en caso de fallos, reanudar la aplicación desde el último estado gu

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3

Martinsson, Hanna-Stina. "Single cell analysis of checkpoints in G₁ /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-455-4/.

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4

Thelakkad, Chathoth Keerthi. "An investigation of splicing-dependent transcriptional checkpoints." Thesis, University of Edinburgh, 2013. http://hdl.handle.net/1842/17547.

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Pre-mRNA splicing and other RNA processing events occur co-transcriptionally. High resolution kinetic studies performed in our lab showed splicing-dependent RNA Pol II (RNA polymerase II) pausing near the 3’ splice site of a reporter gene. Pausing requires splicing, as mutations that block splicing lead to loss of pausing, and restoring splicing restores pausing. It was proposed that RNA Pol II pausing may occur at splicing-dependent transcriptional checkpoints. In this study, I aimed to search for splicing helicases that might couple splicing with transcription. The ts alleles prp5-1 and prp1

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5

Burgess, Andrew J. "Targeting cell cycle checkpoints to specifically kill cancer /." St. Lucia, Qld, 2004. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe17890.pdf.

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6

Gauger, Michele Ann Sancar Aziz. "Cryptochrome, circadian cycle, cell cycle checkpoints, and cancer." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2007. http://dc.lib.unc.edu/u?/etd,971.

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Thesis (Ph. D.)--University of North Carolina at Chapel Hill, 2007.<br>Title from electronic title page (viewed Dec. 18, 2007). "... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Department of Biochemistry and Biophysics." Discipline: Biochemistry and Biophysics; Department/School: Medicine.

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7

Egger, Tom. "Mutations de la voie ATR-CHK1, réponse au stress réplicatif et cancer." Thesis, Montpellier, 2018. http://www.theses.fr/2018MONTT031.

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Le cancer colorectal est responsable de plus de 17500 décès par an et se situe à la 3ème place des cancers les plus fréquents en France. En altérant le processus de réplication de l’ADN des cellules cancéreuses, certaines des molécules utilisées en chimiothérapie induisent du stress réplicatif. Au niveau cellulaire, ce stress est géré par la voie ATR-CHK1. Quand elle est activée par des régions d’ADN simple brin protégées par RPA au niveau de fourches de réplication ralenties/bloquées, ATR déclenche l’activation du checkpoint intra-S via la phosphorylation de son effecteur CHK1. Ce checkpoint

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8

Groom, Joanna Ruth School of Medicine UNSW. "Loss of immune regulatory checkpoints in BAFF transgenic mice." Awarded by:University of New South Wales. School of Medicine, 2006. http://handle.unsw.edu.au/1959.4/27281.

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Multiple checkpoints control the survival and activation of auto-reactive B cells. The discovery of the TNF family cytokine BAFF has been crucial to understanding peripheral B cell tolerance mechanisms. Homeostatic levels of BAFF are tightly regulated to maintain tolerance in the periphery. Chronically increased levels of BAFF lead to the survival of autoreactive B cells. Autoimmune patients display elevated serum BAFF levels. BAFF Tg mice model this situation with systemically high levels of BAFF and the subsequent development of two separate but related autoimmune syndromes; systemic lupus e

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9

Sar, Funda Sancar Aziz. "Understanding the role of Claspin in DNA damage checkpoints." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2006. http://dc.lib.unc.edu/u?/etd,281.

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Thesis (Ph. D.)--University of North Carolina at Chapel Hill, 2006.<br>Title from electronic title page (viewed Oct. 10, 2007). "... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Department of Biochemistry and Biophysics." Discipline: Biochemistry and Biophysics; Department/School: Medicine.

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10

Khan, Salman. "Putting checkpoints to work in thread level speculative execution." Thesis, University of Edinburgh, 2010. http://hdl.handle.net/1842/4676.

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With the advent of Chip Multi Processors (CMPs), improving performance relies on the programmers/compilers to expose thread level parallelism to the underlying hardware. Unfortunately, this is a difficult and error-prone process for the programmers, while state of the art compiler techniques are unable to provide significant benefits for many classes of applications. An interesting alternative is offered by systems that support Thread Level Speculation (TLS), which relieve the programmer and compiler from checking for thread dependencies and instead use the hardware to enforce them. Unfortunat

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11

Griffiths, Dominic John Finbar. "Analysis of DNA structure dependent checkpoints in Schizosaccharomyces pombe." Thesis, University of Sussex, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.294415.

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12

Alkhodairy, Fahad M. "Analysis of checkpoints and dependency relationships in S. pombe." Thesis, University of Sussex, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.333510.

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13

Weitzel, Douglas H. "Modulation of cell cycle checkpoints by anti-cancer agents /." The Ohio State University, 2001. http://rave.ohiolink.edu/etdc/view?acc_num=osu148820531851081.

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14

Wade, Mark. "p53 independent apoptosis and cell cycle checkpoints in human cells." Thesis, Imperial College London, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.251742.

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15

Lee, Hyunsook. "Cell cycle checkpoints and the breast cancer susceptibility gene, BRCA2." Thesis, University of Cambridge, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.624509.

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16

McBride, Claire Marie. "Characterisation of human cell cycle control systems." Thesis, University of Ulster, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.274083.

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17

Williams, Christine Janet. "DNA damage checkpoints in the development of normal and neoplastic lymphocytes." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape8/PQDD_0004/NQ41339.pdf.

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18

LeaÌƒo, Maria JoaÌƒo de Lemos Pinto Estrela. "Modulation of G2/M cell cycle checkpoints by Epstein-Barr virus." Thesis, Imperial College London, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.414473.

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19

Tsang, Ellen. "Interplay between checkpoints and recombination at sites of replication fork arrest." Thesis, University of Sussex, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.488568.

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20

Puett, Ronnie Douglas. "Reconfiguration in robust distributed real-time systems based on global checkpoints." Thesis, Monterey, California. Naval Postgraduate School, 1991. http://hdl.handle.net/10945/26720.

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21

Hass, Cathy Staloch. "Function of Replication Protein A in DNA repair and cell checkpoints." Diss., University of Iowa, 2012. https://ir.uiowa.edu/etd/2515.

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Replication Protein A (RPA), the major eukaryotic single-strand DNA (ssDNA) binding protein, is essential for replication, repair, recombination, and checkpoint activation. Defects in RPA-associated cellular activities lead to genomic instability, a major factor in the pathogenesis of cancer. The ssDNA-binding activity of RPA is primarily mediated by two domains in the RPA1 subunit. I characterized mutant forms of RPA to elucidate the contribution of specific residues in the high affinity DNA binding domains to the cellular function of RPA. These studies enhance the understanding of the proper

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22

Younger, J. Michael Cyr Douglas M. "Selection of misfolded CFTR for proteasomal degradation by sequential Quality Control checkpoints." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2006. http://dc.lib.unc.edu/u?/etd,525.

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Thesis (Ph. D.)--University of North Carolina at Chapel Hill, 2006.<br>Title from electronic title page (viewed Oct. 10, 2007). "... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Department of Cell and Developmental Biology." Discipline: Cell and Developmental Biology; Department/School: Medicine.

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23

LaRocque, Jeannine Ruth Sekelsky Jeff. "DNA damage response in Drosophila melanogaster orchestrating repair with cell cycle checkpoints /." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2007. http://dc.lib.unc.edu/u?/etd,1131.

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Thesis (Ph. D.)--University of North Carolina at Chapel Hill, 2007.<br>Title from electronic title page (viewed Mar. 27, 2008). "... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Department of Biology." Discipline: Biology; Department/School: Biology.

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24

Ongkeko, Weg M. "The role of Cdc2 and p53 in cell cycle checkpoints and apoptosis." Thesis, University of Oxford, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.244848.

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25

Buligon, Clairton. "Implementação de recuperação por retorno de aplicações distribuídas baseada em checkpoints coordenados." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2005. http://hdl.handle.net/10183/5018.

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A recuperação por retorno baseada em checkpointing é largamente usada como técnica de tolerância a falhas. O modelo complexo de sistemas distribuídos tem motivado o desenvolvimento de diversos algoritmos na tentativa de encontrar soluções mais simples e eficientes. Os processos que formam o sistema distribuído podem coordenar suas operações para garantir que o conjunto de checkpoints locais componha um estado global consistente (linha de recuperação). A partir desse estado, no caso de ocorrência de falhas, o sistema pode ser recuperado e a computação retomada a partir de um momento anterior ao

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26

Ahmed, Bokhtiar. "Beyond checkpoints: Identity and developmental politics in the Chittagong Hill Tracts, Bangladesh." Thesis, Australian Catholic University, 2017. https://acuresearchbank.acu.edu.au/download/9e31dff5c8745177718766afd3331cb84f4f7326d38e69b70d066b6a2be37383/8687922/Ahmed_2017_Beyond_checkpoints_identity_and_developmental_politics.pdf.

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This thesis is about contemporary identity and developmental politics in the Chittagong Hill Tracts (CHT) of Bangladesh. Based on ethnographic research among the Pangkhuas, one of the twelve marginal ethnic groups living here, the thesis examines the everyday forms of identity and developmental practices in relation to a continuous hegemonic articulation of the state’s presence in this geopolitical margin. The central methodology of the research has been multi-sited ethnography characterized by anti-essentialism. A number of key themes and issues are explored in this thesis. First, the process

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27

Chow, Jeremy Pak Hong. "Inhibitory phosphorylation of cyclin-dependent kinases in normal cell cycle and checkpoints /." View Abstract or Full-Text, 2003. http://library.ust.hk/cgi/db/thesis.pl?BICH%202003%20CHOW.

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Thesis (M. Phil.)--Hong Kong University of Science and Technology, 2003.<br>Includes bibliographical references (leaves 127-148). Also available in electronic version. Access restricted to campus users.

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28

Surapu, Reddy Padmakar Reddy. "NON-BLOCKING ROLL-FORWARD RECOVERY APPROACH FOR DISTRIBUTED SYSTEMS." Available to subscribers only, 2009. http://proquest.umi.com/pqdweb?did=1966550061&sid=5&Fmt=2&clientId=1509&RQT=309&VName=PQD.

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29

Santhana, Krishnan Archanaa. "Top-down Approach To Securing Intermittent Embedded Systems." Diss., Virginia Tech, 2021. http://hdl.handle.net/10919/105128.

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The conventional computing techniques are based on the assumption of a near constant source of input power. While this assumption is reasonable for high-end devices such as servers and mobile phones, it does not always hold in embedded devices. An increasing number of Internet of Things (IoTs) is powered by intermittent power supplies which harvest energy from ambient resources, such as vibrations. While the energy harvesters provide energy autonomy, they introduce uncertainty in input power. Intermittent computing techniques were proposed as a coping mechanism to ensure forward progress even

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30

Boekhold, Josephus Wilhelmus Anna Sibilla van. "Evaluating security screening checkpoints for domestic flights using a general microscopic simulation model." Access to citation, abstract and download form provided by ProQuest Information and Learning Company; downloadable PDF file 1.89 Mb., 242 p, 2006. http://proquest.umi.com/pqdlink?did=1163268061&Fmt=7&clientId=79356&RQT=309&VName=PQD.

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31

Richards, Andrea. "The role of vacuoles in size-dependent cell cycle checkpoints in Candida albicans." Thesis, University of Aberdeen, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.540457.

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A size-mediated checkpoint operates at the beginning of each new cell cycle in budding yeast. This checkpoint, named Start, coordinates cell growth with cell division so that cells retain a uniform size over many generations. Evidence from studies using polymorphic fungus <i>Candida albicans </i>shows that vacuole content of a cell influences timing of Start, suggesting that the space occupied by vacuole material influences size-dependent functions of the cell cycle. This thesis explores the hypothesis that the volume of the cytoplasm (i.e. minus the volume of the vacuole and other organell

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32

Playle, Laura Charlotte. "Radiation-induced apoptosis and cell cycle checkpoints in human colorectal tumour cell lines." Thesis, University of Bristol, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.341501.

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33

Thomas, Sally Edwina. "The role of cell cycle checkpoints in the survival of endoplasmic reticulum stress." Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.608043.

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34

Preuss, Sasha Ben. "The genetic dissection of DNA damage induced cell cycle checkpoints in Arabidopsis thaliana /." For electronic version search Digital dissertations database. Restricted to UC campuses. Access is free to UC campus dissertations, 2002. http://uclibs.org/PID/11984.

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35

Houles, Thibault. "Rôle de E4F1 dans la régulation de l'homéostasie des cellules cancéreuses." Thesis, Montpellier, 2015. http://www.theses.fr/2015MONTS053.

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E4F1 est un facteur de transcription liant l'ADN, exprimé de façon ubiquitaire par tous les tissus, et qui possède une activité E3 ubiquitine ligase atypique dirigée contre le suppresseur de tumeur p53. La protéine E4F1 interagit directement avec plusieurs suppresseurs de tumeurs cellulaires et des oncogènes viraux (p53, pRb, DRAL, RASSF1A, p19ARF, BMI1, HBX et GAM1...), suggérant qu’elle est elle-même impliquée dans la tumorigenèse. La perte d’E4F1 dans des fibroblastes embryonnaires (Mefs) transformés ou dans des cellules de sarcomes histiocytaires déficientes pour la voie p53, entraine la m

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36

Ivanova, Tsvetomira Georgieva 1978. "The DNA damage and the DNA synthesis checkpoints converge at the MBF transcription factor." Doctoral thesis, Universitat Pompeu Fabra, 2012. http://hdl.handle.net/10803/116932.

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DNA damage is an ongoing threat to both the ability of the cell to faithfully transmit genetic information to its offspring as well as to its own survival. In order to maintain genomic integrity, eukaryotes have developed a highly conserved mechanism to detect, signal and repair damage in DNA, known as the DNA damage response (DDR). In fission yeast the two DDR pathways converge at the regulation of single transcriptional factor complex (MBF) resulting in opposite directions. We have shown that when the DNA-synthesis checkpoint is activated, Max1 is phosphorylated by Cds1 resulting in the abro

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37

Lowery, Drew M. "Modulation of mitotic progression and cell cycle checkpoints by phosphorylation-dependent protein-protein interactions." Thesis, Massachusetts Institute of Technology, 2007. http://hdl.handle.net/1721.1/40953.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 2007.<br>Includes bibliographical references.<br>Alteration of mitotic gene function has recently been discovered to play a key role in tumor formation and cancer progression through the induction of chromosomal aberrations and genomic instability. Polo-like-kinase-1 is a critical mitotic regulator, overexpressed in human tumors, that functions in mitotic entry after cellular stress, centrosome maturation, mitotic spindle control, and cytokinesis, which are all disregulated in cancer cells. To study the role of Polo-like

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38

O'Nions, Jenny Clare. "Regulation of proliferation and cell cycle checkpoints in EBV infected and normal human B cells." Thesis, Imperial College London, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.406421.

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39

Ullah, Matti. "Immune Checkpoints in Peritoneal Carcinomatosis : HLA-G, PD-L1 & the Impact of Cancer Therapies." Thesis, Université Paris-Saclay (ComUE), 2019. http://www.theses.fr/2019SACLS288.

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Carcinomatose péritonéale est un terme utilisé pour désigner la dissémination métastatique généralisée du cancer dans la cavité péritonéale. Il se caractérise par l’accumulation de liquide appelé « ascite » et est considéré comme étant au stade terminal du cancer, car il est difficile à traiter. L'ascite accumulée dans la PC comprend des cellules tumorales, cytokines et cellules immunitaires. Les cellules cancéreuses expriment des protéines spécifiques qui les aident à supprimer les cellules immunitaires et à survivre, appelées points de contrôle immunitaires. Des points de contrôle immunitair

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40

Zielonka, Elisabeth Maria. "The function of p53 homologs in oocyte meiotic checkpoints and the innate airway immune system." Strasbourg, 2011. http://www.theses.fr/2011STRA6041.

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P53, un important gène suppresseur de tumeur, est muté dans plus de 70% des cancers. Ses paralogues p63 et p73 sont présents chez les mammifères mais diffèrent structuralement de p53. Les femelles ne possèdent qu’un réservoir limité de gamètes bloqués à la naissance au stade dictyé. Durant cette phase, les ovocytes sont très sensibles aux dommages de l'ADN, provoquant l'apoptose et réduisant la fertilité. TAp63α est un acteur clé du maintien de l'intégrité génomique dans les ovocytes. La cassure par irradiation du double brin d'ADN active TAp63α par phosphorylation. Contrairement à TAp63α, p53

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41

Eriksson, Sebastian, and Sebastian Zethraeus. "Man blir lite taggad men också frustrerad : En explorativ studie av checkpoints i spelet A Story About My Uncle." Thesis, Södertörns högskola, Institutionen för naturvetenskap, miljö och teknik, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:sh:diva-22233.

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In this study we pose the question if you through finding patterns in implementation of checkpoints can find ways to tailor the experience of the game A Story About My Uncle to hardcore gamers. To find out the answer we had hardcore players playing a modified level from the game A Story About My Uncle that was used as stimulus material for the following focus group interview. The analysis of the gathered material resulted in four patterns that can be used when implementing checkpoints to tailor the experience of the game A Story About My Uncle to hardcore gamers. Elements of checkpoints that o

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42

Haghnazari, Edwin. "Regulation of homologous recombinational DNA repair by DNA damage and replication block checkpoints in Saccharomyces cerevisiae /." For electronic version search Digital dissertations database. Restricted to UC campuses. Access is free to UC campus dissertations, 2004. http://uclibs.org/PID/11984.

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43

GREPPI, MARCO. "Expression, role and regulation of NK cell immune checkpoints (PD-1, KIRs, NKG2A) in Ovarian Cancer." Doctoral thesis, Università degli studi di Genova, 2021. http://hdl.handle.net/11567/1047416.

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Outstanding results can be obtained with immune-checkpoints (ICs)/ligands blockade strategies (mainly PD-1/PD-L axis) in immunotherapeutic protocols for aggressive tumors. We previously showed that higher proportions of PD-1+NK cells can be detected in ovarian cancer (OC) patients. Here, we deeply characterized the features of the PD-1+NK cell subset in a large cohort of patients with high-grade serous OC subtype with the aim to dissect the NK/tumor interconnections existing in this TME. We identified two new PD-1+NK subsets occurring only in OC patients, primarily in the peritoneal fluid (PF)

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44

Wu, Jiang. "CHECKPOINTING AND RECOVERY IN DISTRIBUTED AND DATABASE SYSTEMS." UKnowledge, 2011. http://uknowledge.uky.edu/cs_etds/2.

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A transaction-consistent global checkpoint of a database records a state of the database which reflects the effect of only completed transactions and not the re- sults of any partially executed transactions. This thesis establishes the necessary and sufficient conditions for a checkpoint of a data item (or the checkpoints of a set of data items) to be part of a transaction-consistent global checkpoint of the database. This result would be useful for constructing transaction-consistent global checkpoints incrementally from the checkpoints of each individual data item of a database. By applying

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45

Myer, David. "Role of the Mammalian Polo-Like Kinase 3(Plk3) in Cell Cycle Regulation and DNA Damage Checkpoints." University of Cincinnati / OhioLINK, 2006. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1141395911.

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NOCI, V. M. LE. "CANCER THERAPY THROUGH TLR-INDUCED LOCAL INNATE IMMUNITY ACTIVATION AND BLOCK OF IMMUNE CHECKPOINTS OR SUPPRESSIVE CELLS." Doctoral thesis, Università degli Studi di Milano, 2017. http://hdl.handle.net/2434/480559.

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The immunostimulatory ability of oligonucleotides containing CpG motif (CpG-ODN), agonists of TLR9, can be harnessed to promote antitumor immunity by their application at the tumor site to stimulate local activation of innate immunity; however, this is not always true for lung tumor where the immunosuppressive microenvironment, crucial to avoid tissue damage by inflammatory response to the continuous exposition to inhaled particles, limits the power of immunotherapy. Thus, the tumor microenvironment is a critical factor for successful use of these immunotherapeutics, and strategies to shift a

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47

Liu, Shengqin. "Effects of arsenic on DNA repair and cell cell checkpoints involvement in arsenic co-mutagenesis and co-carcinogenesis /." Cincinnati, Ohio : University of Cincinnati, 2005. http://www.ohiolink.edu/etd/view.cgi?acc%5Fnum=ucin1109283103.

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48

Dempsey, Kristina. "Examining the Relationship Among Middle School Students’ Performance on the TNReady Assessment, District Checkpoints, and Teacher-Assigned Grades." Digital Commons @ East Tennessee State University, 2020. https://dc.etsu.edu/etd/3799.

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The purpose of this nonexperimental, quantitative study was to determine if there is a significant correlation among teacher-assigned grades (TAG), district checkpoint scores (CP), and student scale-scores on TNReady tests. The focus was on 1,445 seventh and eighth grade students who were enrolled at a middle school in northeast Tennessee during the academic years of 2017-2018 and 2018-2019, specifically for the content areas of English Language Arts and mathematics. The second purpose of this study was to examine any moderating effects of the categorical variable, students with disabilities (

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49

LIU, SHENGQIN. "EFFECTS OF ARSENIC ON DNA REPAIR AND CELL CELL CHECKPOINTS: INVOLVEMENT IN ARSENIC CO-MUTAGENESIS AND CO-CARCINOGENESIS." University of Cincinnati / OhioLINK, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1109283103.

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50

Casadei, Beatrice <1986&gt. "Ruolo del Microbiota Intestinale Nella Risposta al Trattamento con Anticorpi anti Checkpoints Immunitari in Pazienti Affetti da Linfoma." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2021. http://amsdottorato.unibo.it/9789/1/Casadei%20B.%20PhD%20Def.pdf.

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L’interazione tra il sistema immunitario dell’ospite e la cellula tumorale rappresenta uno degli elementi cardine dello sviluppo del clone neoplastico: la capacità della cellula cancerosa di evadere il controllo immunitario sfruttando meccanismi fisiologici come i checkpoint immunitari è alla base di diverse neoplasie, incluse le sindromi linfoproliferative. Lo sviluppo di anticorpi monoclonali che bloccano selettivamente l’interazione tra il recettore trans-membrana PD-1 (programmed death -1) ed i propri ligandi (PD-L1 e PD-L2), rappresenta una delle scoperte terapeutiche più promettenti in a

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