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Journal articles on the topic 'Chelidonium majus'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

Pavlenko, Oleksii, and Iryna Strokina. "The influences of alkaloids of Chelidonium majus L., Colchicum autumnale L, Catharanthus roseus (L.) G.Don and Vinca minor L. on malignant neoplasms, the review of modern researches." Ukrainian Scientific Medical Youth Journal 142, no. 4 (2023): 145–52. http://dx.doi.org/10.32345/usmyj.4(142).2023.145-152.

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natural alkaloids of Chelidonium majus L., Colchicum autumnale L. and Catharanthus roseus (L.) G.Don are anticancer agents. Some of them, such as colchicine, vincristine and vinblastine, are used in modern medicine, as chemotherapy medicines against malignant neoplasms, some of them are effective supplement to conventional methods or works to prevent cancer onset (chelidonine, sanguinarine, chelerythrine, protopine and allocryptopine). The effect of mitotic poisons that are alkaloids of Colchicum autumnale colchicine, Catharanthus roseus vincristine and vinblastine against malignant neoplasms

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2

&NA;. "Chelidonium majus." Reactions Weekly &NA;, no. 1264 (2009): 11. http://dx.doi.org/10.2165/00128415-200912640-00034.

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3

&NA;. "Chelidonium majus." Reactions Weekly &NA;, no. 1230 (2008): 12. http://dx.doi.org/10.2165/00128415-200812300-00034.

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4

Desmichelle, G. "Chelidonium majus." British Homoeopathic journal 79, no. 1 (1990): 67. http://dx.doi.org/10.1016/s0007-0785(05)80139-5.

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5

Zhalsrai, A., and L. Ts Sanzhieva. "The Study of the Neuroprotective Effect of the Extract from Chelidonium Majus L. in Vitro." Acta Biomedica Scientifica 4, no. 2 (2019): 106–13. http://dx.doi.org/10.29413/abs.2019-4.2.15.

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The protection of neurons from damage and death is an important challenge in the development of treatment of brain ischemia and neurodegenerative diseases. This study aims to investigate protective effect of the extract prepared from Chelidonium majus, which contains total alkaloids. In the present study, we examined antioxidant activity of total alkaloids from Chelidonium majus in vitro. Hydroxyl radical and lipid radicals were detected using spin trapping agents with ESR spectrometer. Chelidonium majus extract exhibited dose-dependent scavenging effects on lipid radicals. Halfmaximal inhibit

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Kaminskyy, Vitaliy, Maxim Lootsik, and Rostyslav Stoika. "Correlation of the cytotoxic activity of four different alkaloids, from Chelidonium majus (greater celandine), with their DNA intercalating properties and ability to induce breaks in the DNA of NK/Ly murine lymphoma cells." Open Life Sciences 1, no. 1 (2006): 2–15. http://dx.doi.org/10.2478/s11535-006-0001-y.

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AbstractThe purpose of this study was to examine the relationship between the DNA intercalating characteristics and the DNA damaging capacity of four alkaloids extracted from Chelidonium majus L, as well as their toxicity towards murine NK/Ly lymphoma cells. Chelerythrine, sanguinarine and coptisine were found to be intercalated into the DNA isolated from NK/Ly cells, meanwhile, chelidonine exhibited no affinity to DNA. Sanguinarine exhibited the greatest toxicity toward NK/Ly cells, and the toxicity of the other three decreased in descending order: chelerythrine, coptisine and chelidonine. Ch

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7

&NA;. "Chelidonium majus/Lycopodium serratum." Reactions Weekly &NA;, no. 1268 (2009): 13. http://dx.doi.org/10.2165/00128415-200912680-00038.

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8

Schilcher, Heinz. "Heilpflanzenporträt: Schöllkraut – Chelidonium majus." Zeitschrift für Komplementärmedizin 2, no. 05 (2010): 54–55. http://dx.doi.org/10.1055/s-0030-1250304.

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9

Cahlíková, Lucie, Lubomír Opletal, Milan Kurfürst, Kateřina Macáková, Andrea Kulhánková, and Anna Hošt'álková. "Acetylcholinesterase and Butyrylcholinesterase Inhibitory Compounds from Chelidonium Majus (Papaveraceae)." Natural Product Communications 5, no. 11 (2010): 1934578X1000501. http://dx.doi.org/10.1177/1934578x1000501110.

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The roots and aerial parts of Chelidonium majus L. were extracted with EtOH and fractionated using CHCl3 and EtOH. Repeated column chromatography, preparative TLC and crystallization led to the isolation of five isoquinoline alkaloids, stylopine (3), chelidonine (4), homochelidonine (5), protopine (6), and allocryptopine (7), along with two isolation artifacts 6-ethoxydihydrosanguinarine (1) and 6-ethoxydihydrochelerythrine (2). All isolated compounds were tested for human blood acetylcholinesterase (HuAChE) and human plasma butyrylcholinesterase (HuBuChE) inhibitory activity. The isolation ar

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10

Och, Anna, Daniel Zalewski, Łukasz Komsta, Przemysław Kołodziej, Janusz Kocki, and Anna Bogucka-Kocka. "Cytotoxic and Proapoptotic Activity of Sanguinarine, Berberine, and Extracts of Chelidonium majus L. and Berberis thunbergii DC. toward Hematopoietic Cancer Cell Lines." Toxins 11, no. 9 (2019): 485. http://dx.doi.org/10.3390/toxins11090485.

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Isoquinoline alkaloids belong to the toxic secondary metabolites occurring in plants of many families. The high biological activity makes these compounds promising agents for use in medicine, particularly as anticancer drugs. The aim of our study was to evaluate the cytotoxicity and proapoptotic activity of sanguinarine, berberine, and extracts of Chelidonium majus L. and Berberis thunbergii DC. IC10, IC50, and IC90 doses were established toward hematopoietic cancer cell lines using trypan blue staining. Alterations in the expression of 18 apoptosis-related genes in cells exposed to IC10, IC50

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Jang, Hyun-Jin, Jae Ho Yang, Eunmi Hong, et al. "Chelidonine Induces Apoptosis via GADD45a-p53 Regulation in Human Pancreatic Cancer Cells." Integrative Cancer Therapies 20 (January 2021): 153473542110061. http://dx.doi.org/10.1177/15347354211006191.

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Chelidonium majus has been used as a traditional medicine in China and western countries for various diseases, including inflammation and cancer. However, the anti-cancer effect of chelidonine, a major compound of C. majus extracts, on pancreatic cancer remains poorly understood. In this study, we found that treatment with chelidonine inhibited proliferation of BxPC-3 and MIA PaCa-2 human pancreatic cancer cells. Annexin-V/propidium iodide staining assay showed that this growth inhibitory effect of chelidonine was induced through apoptosis. We found that chelidonine treatment upregulated mRNA

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Im, Sung Gyu, Sun Hong Yoo, Dong Ok Jeon, et al. "Chelidonium majus-Induced Acute Hepatitis." Ewha Medical Journal 37, no. 1 (2014): 60. http://dx.doi.org/10.12771/emj.2014.37.1.60.

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13

DUMITRIU BUZIA, Olimpia, Geanina Mihaela Ion, Kamel Earar, Gabriela Gurau, and Nela Mardare. "ANTIMICROBIAL ACTIVITY OF CHELIDONIUM SPECIES MAJUS L." Medicine and Materials 2, no. 1 (2022): 31–38. http://dx.doi.org/10.36868/medmater.2022.02.01.031.

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The present paper has as main objective the determination of the antimicrobial and antifungal activity of some pharmaceutical forms obtained in the laboratory of pharmaceutical technology of the Faculty of Pharmacy of the University "Lower Danube of Galati". We used semi-solid pharmaceutical forms with different concentrations of soft extract of Chelidonium majus L, 50%, 25% and 10% in two ointment bases, simple ointment and base III I performed the antimicrobial activity for all four ointments, compared to extract 1: 3.75 in hydroalcoholic solution (ethyl alcohol / water 35/65 by mass) from a

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14

Tuzimski, Tomasz, Anna Petruczynik, Tomasz Plech, et al. "Determination of Selected Isoquinoline Alkaloids from Chelidonium majus, Mahonia aquifolium and Sanguinaria canadensis Extracts by Liquid Chromatography and Their In Vitro and In Vivo Cytotoxic Activity against Human Cancer Cells." International Journal of Molecular Sciences 24, no. 7 (2023): 6360. http://dx.doi.org/10.3390/ijms24076360.

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The search for new substances with cytotoxic activity against various cancer cells, especially cells that are very resistant to currently used chemotherapeutic agents, such as melanoma cells, is a very important scientific aspect. We investigated the cytotoxic effect of Chelidonium majus, Mahonia aquifolium and Sanguinaria canadensis extracts obtained from different parts of these plants collected at various vegetation stages on FaDu, SCC-25, MCF-7, and MDA-MB-231 cancer cells. Almost all the tested extracts showed higher cytotoxicity against these cancer cells than the anticancer drug etoposi

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15

Zielińska, Sylwia, Monika Ewa Czerwińska, Magdalena Dziągwa-Becker, et al. "Modulatory Effect of Chelidonium majus Extract and Its Alkaloids on LPS-Stimulated Cytokine Secretion in Human Neutrophils." Molecules 25, no. 4 (2020): 842. http://dx.doi.org/10.3390/molecules25040842.

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Due to certain differences in terms of molecular structure, isoquinoline alkaloids from Chelidonium majus engage in various biological activities. Apart from their well-documented antimicrobial potential, some phenanthridine and protoberberine derivatives as well as C. majus extract present with anti-inflammatory and cytotoxic effects. In this study, the LC–MS/MS method was used to determine alkaloids, phenolic acids, carboxylic acids, and hydroxybenzoic acids. We investigated five individually tested alkaloids (coptisine, berberine, chelidonine, chelerythrine, and sanguinarine) as well as C.

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16

Fik, E., M. Dalgalarrondo, T. Haertlé, and A. Goździcka-Józefiak. "Comparative biochemical analysis of lectin and nuclease from Chelidonium majus L." Acta Biochimica Polonica 47, no. 2 (2000): 413–20. http://dx.doi.org/10.18388/abp.2000_4020.

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It has been recently recognized that lectins exhibit other activities besides hemagglutination. Previously we have found that purified lectin from Chelidonium majus showed DNase activity (Fik, Goździcka-Józefiak & Kedzia, 1995, Herba Polon. 41, 84-95). Comparison of lectin and DNase from the sap from leaves and roots of Chelidonium majus proved that both these compounds are composed of 24 kDa monomer subunits which have an identical N-terminal sequence but differ in amino-acid composition and degree of glycosylation. Possible interrelationship between lectin and DNase is discussed.

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17

Topor, Gabi, Cristina Stanescu, Olimpia Dumitriu Buzia, Doriana Agop Forna, and Cristina Serban. "ANTIMICROBIAL ACTIVITY A CHELIDONIUM SPECIES MAJUS L." Romanian Journal of Oral Rehabilitation 16, no. 3 (2024): 678–87. https://doi.org/10.62610/rjor.2024.3.16.68.

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The present paper has as main objective the determination of the antimicrobial and antifungal activity of some pharmaceutical forms obtained in the laboratory of pharmaceutical technology of the Faculty of Pharmacy of the University “Lower Danube of Galati”. We used semi-solid pharmaceutical forms with different concentrations of soft extract of Chelidonium majus L, 50%, 25% and 10% in two ointment bases, simple ointment and base III I performed the antimicrobial activity for all four ointments, compared to extract 1: 3.75 in hydroalcoholic solution (ethyl alcohol / water 35/65 by mass) from a

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18

ÇİTOĞLU, SALTAN, Gülçin; ÖZBEK, Hanefi; Hanefi;, Özlem; Özlem;, and Eszter Eszter. "Solation of chelidonine as an analgesic compound from Chelidonium Majus L." Ankara Universitesi Eczacilik Fakultesi Dergisi 38, no. 1 (2009): 9–16. http://dx.doi.org/10.1501/eczfak_0000000513.

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19

Lee, Yeon-Kyeong, Ki Won Lee, Minju Kim, et al. "Chelidonine Induces Caspase-Dependent and Caspase-Independent Cell Death through G2/M Arrest in the T98G Human Glioblastoma Cell Line." Evidence-Based Complementary and Alternative Medicine 2019 (May 26, 2019): 1–8. http://dx.doi.org/10.1155/2019/6318179.

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Chelidonium majus L. (family Papaveraceae), commonly known as greater celandine or tetterwort, has been reported to have antibacterial and anticancer effects and chelidonine is known as a functional metabolite extracted from C. majus. In this study, we observed the cytotoxicity of the alkaloid, chelidonine, and investigated its functional mechanism in T98G glioblastoma cell line. Chelidonine induced apoptosis in a dose-dependent manner, which was accompanied by decreased antiapoptotic protein Mcl-1. Caspase-3 and -9 were activated by treatment with chelidonine, but chelidonine-mediated apoptos

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20

Ljubešić, Nikola, and Mercedes Wrischer. "Chromoplast biogenesis in Chelidonium majus petals." Acta Societatis Botanicorum Poloniae 75, no. 2 (2011): 107–12. http://dx.doi.org/10.5586/asbp.2006.013.

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The differentiation of chromoplasts, with special emphasis on the formation and the organisation of chromoplast fibrils, was followed in the petals of the greater celandine, <em>Chelidonium majus</em> L. Electron microscopic observations showed that, in the epidermis, differentiation of chromoplasts started from leucoplasts, while mesophyll chromoplasts originated from chloroplasts. During petal maturation, fibrils accumulated in the plastids, often arranging in a parallel fashion to form compact birefringent bundles. Immediately before flower opening, these fibrillar bundles start

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21

Paczkowska, Magdalena, Justyna Chanaj-Kaczmarek, Aleksandra Romaniuk-Drapała, et al. "Mucoadhesive Chitosan Delivery System with Chelidonii Herba Lyophilized Extract as a Promising Strategy for Vaginitis Treatment." Journal of Clinical Medicine 9, no. 4 (2020): 1208. http://dx.doi.org/10.3390/jcm9041208.

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Chelidonium majus (also known as celandine) contains pharmacologically active compounds such as isoquinoline alkaloids (e.g., chelidonine, sanguinarine), flavonoids, saponins, carotenoids, and organic acids. Due to the presence of isoquinoline alkaloids, Chelidonii herba extracts are widely used as an antibacterial, antifungal, antiviral (including HSV-1 and HIV-1), and anti-inflammatory agent in the treatment of various diseases, while chitosan is a biocompatible and biodegradable carrier with valuable properties for mucoadhesive formulations preparation. Our work aimed to prepare mucoadhesiv

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22

Och, Anna, Katarzyna Szewczyk, Łukasz Pecio, Anna Stochmal, Daniel Załuski, and Anna Bogucka-Kocka. "UPLC-MS/MS Profile of Alkaloids with Cytotoxic Properties of Selected Medicinal Plants of the Berberidaceae and Papaveraceae Families." Oxidative Medicine and Cellular Longevity 2017 (2017): 1–7. http://dx.doi.org/10.1155/2017/9369872.

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Cancer is one of the most occurring diseases in developed and developing countries. Plant-based compounds are still researched for their anticancer activity and for their quantity in plants. Therefore, the modern chromatographic methods are applied to quantify them in plants, for example, UPLC-MS/MS (ultraperformance liquid chromatography tandem mass spectrometry). Therefore, the aim of the present study was to evaluate the content of sanguinarine, berberine, protopine, and chelidonine in Dicentra spectabilis (L.) Lem., Fumaria officinalis L., Glaucium flavum Crantz, Corydalis cava L., Berberi

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23

Strzemski, Maciej, Sławomir Dresler, Beata Podkościelna, et al. "Effectiveness of Volatile Natural Deep Eutectic Solvents (VNADESs) for the Green Extraction of Chelidonium majus Isoquinoline Alkaloids." Molecules 27, no. 9 (2022): 2815. http://dx.doi.org/10.3390/molecules27092815.

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The Chelidonium majus plant is rich in biologically active isoquinoline alkaloids. These alkaline polar compounds are isolated from raw materials with the use of acidified water or methanol; next, after alkalisation of the extract, they are extracted using chloroform or dichloromethane. This procedure requires the use of toxic solvents. The present study assessed the possibility of using volatile natural deep eutectic solvents (VNADESs) for the efficient and environmentally friendly extraction of Chelidonium alkaloids. The roots and herb of the plant were subjected three times to extraction wi

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Кармалиев, Рашид, Нуржанова Ф. Х., Ертлеуова Б. О. та Сидихов Б. М. "ОЦЕНКА АНТИМИКРОБНЫХ СВОЙСТВ ЛЕКАРСТВЕННЫХ РАСТЕНИЙ ДЛЯ РАЗРАБОТКИ КОМПЛЕКСНОГО РАСТИТЕЛЬНОГО ПРЕПАРАТА". Ġylym ža̋ne bìlìm 1, № 1(74) (2024): 28–40. https://doi.org/10.52578/2305-9397-2024-1-1-28-40.

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Аннотация. Проведено изучение антимикробных свойств настоев растений полыни (Artemisia absinthum, Artemisia lerchiana), зверобоя (Hypericum perforatum), череды (Bidens tripartita), чистотела (Chelidonium majus), календулы (Calendula оfficinalis) и ромашки (Сhamomilla recutita) in vitro методом задержки роста культуры тест-микробов Staphylococcus aureus, Streptococcus и Escherichia сoli на МПБ и МПА. Указанные растения обладают антисептическим, противосудорожным, антимикробным, противопаразитарным, дезинфицирующим, кровоостанавливающим, успокаивающим, ранозаживляющим обезболивающим, противовосп

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Krizhanovska, Valerija, Inga Sile, Arta Kronberga, et al. "The Cultivation of Chelidonium majus L. Increased the Total Alkaloid Content and Cytotoxic Activity Compared with Those of Wild-Grown Plants." Plants 10, no. 9 (2021): 1971. http://dx.doi.org/10.3390/plants10091971.

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The effect of cultivation practises on both the phytochemical profile and biological activity of aqueous ethanol extracts of Chelidonium majus L. was studied. Extracts were prepared from aerial parts of the same plant population collected in the wild and grown under organic farming conditions. Both qualitative and quantitative analyses of alkaloids and flavonoid derivatives were performed by LC/MS methods, and the cytotoxicity of lyophilised extracts was studied in B16-F10, HepG2, and CaCo-2 cells. Coptisine was the dominant alkaloid of extracts prepared from wild-grown plants, whereas after c

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Hauser, Marie-Theres, and Michael Wink. "Uptake of Alkaloids by Latex Vesicles and Isolated Mesophyll Vacuoles of Chelidonium ntajus (Papaveraceae)." Zeitschrift für Naturforschung C 45, no. 9-10 (1990): 949–57. http://dx.doi.org/10.1515/znc-1990-9-1005.

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Abstract Latex vacuoles of Chelidonium majus (Papaveraceae) naturally sequester protoberberine and benzophenanthridine alkaloids. Isolated vesicles take up a number of other heterologous alkaloids, such as 9,10-dihydroergocryptine, vinblastine, strychnine, nicotine, colchicine, lupanine, and 13-hydroxylupanine, with a strong preference for the indole alkaloids and for nicotine. Kinetic data clearly show that the uptake proceeds via simple diffusion and not by carrier-mediated transport. The alkaloids are concentrated in the vesicles against a concentra tion gradient. MgATP has no influence on

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Staniak, Wójciak-Kosior, Sowa, et al. "Applicability of a Monolithic Column for Separation of Isoquinoline Alkalodis from Chelidonium majus Extract." Molecules 24, no. 19 (2019): 3612. http://dx.doi.org/10.3390/molecules24193612.

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Isoquinoline alkaloids are the main group of secondary metabolites present in Chelidonium majus extracts, and they are still the object of interest of many researchers. Therefore, the development of methods for the investigation and separation of the alkaloids is still an important task. In this work, the application potential of a silica-based monolithic column for the separation of alkaloids was assessed. The influence of the organic modifier, temperature, salt concentration, and pH of the eluent on basic chromatographic parameters such as retention, resolution between neighboring peaks, chr

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Rogelj, Boris, Tatjana Popovič, Anka Ritonja, Borut Štrukelj, and Jože Brzin. "Chelidocystatin, a novel phytocystatin from Chelidonium majus." Phytochemistry 49, no. 6 (1998): 1645–49. http://dx.doi.org/10.1016/s0031-9422(98)00281-7.

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Vachnadze, N. S., A. D. Bozhadze, D. T. Berashvili, A. J. Bakuridze, and V. Yu Vachnadze. "Alkaloids from Chelidonium majus growing in Georgia." Chemistry of Natural Compounds 48, no. 5 (2012): 921. http://dx.doi.org/10.1007/s10600-012-0427-6.

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Kadan, Gülden, Tekant Gözler, and Maurice Shamma. "(-)-Turkiyenine, a New Alkaloid from Chelidonium majus." Journal of Natural Products 53, no. 2 (1990): 531–32. http://dx.doi.org/10.1021/np50068a046.

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De Rosa, Salvatore, and Giuseppe Di Vincenzo. "Isochelidonine, a benzophenanthridine alkaloid from chelidonium majus." Phytochemistry 31, no. 3 (1992): 1085–86. http://dx.doi.org/10.1016/0031-9422(92)80089-w.

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De Rosa, S. "Isochelidonine, a benzophenanthridine alkaloid from chelidonium majus." Phytochemistry 31, no. 2 (1992): 1085–86. http://dx.doi.org/10.1016/0031-9422(92)80235-7.

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Cord, Daniel, Mirela Claudia Rimbu, Cristiana Tanase, Cristina Tablet, and Gheorghe Duca. "Molecular docking study of some active principles from Silybum marianum, Chelidonium majus, ginkgo biloba, gelsemium sempervirens, Artemisia annua, and taraxacum officinale." Chemistry Journal of Moldova 20, no. 1 (2025): 100–105. https://doi.org/10.19261/cjm.2025.1337.

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In this study, it was investigated by molecular docking, the interaction of fourteen natural compounds (artemisinin, bilobalide, bilobetin, chelerythrine, chelidonin, epicatechin, gelsemic acid, ginkgolide A, isosilybin, silicristin, silybin, taraxacin, taraxacoside, and taraxinic acid) from Silbum marianum, Chelidonium majus, Ginkgo biloba, Gelsemium sempervirens, Artemisia annua, and Taraxacum officinale with three cancer-related GPCRs: the apelin receptor, the β2-adrenoceptor, and the A2B adenosine receptor. QuickVina2 was used to determine the binding affinities and identify the nature of

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Korotkikh, Mikhail Olegovich, Elena Petrovna Romanenko, Vera Dmitriyevna Tikhova, and Aleksej Vasil'evich Tkachev. "INVESTIGATION OF CELANDINE EXTRACTS (CHELIDONIUM MAJUS L.) BY 1H NMR AND QNMR METHODS." chemistry of plant raw material, no. 1 (March 13, 2023): 101–14. http://dx.doi.org/10.14258/jcprm.20230111663.

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The analysis of Celandine extracts (Chelidonium majus L.) by 1H NMR method makes it possible to identify the main alkaloids – derivatives of phenanthridine, protoberberin and protopin, and the use of the qNMR method provides information with satisfactory accuracy about the content of these alkaloids. The content of alkaloids determined in the composition of Celandine extracts by the qNMR method (0.35%) is 2 times lower than when using the spectrophotometric determination procedure described in the GF of the Russian Federation XIV (0.72%). The extraction results according to the methods given i

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Chinan, Vasilică-Claudiu. "Occurrence of the sexual morph of Erysiphe macleayae on Chelidonium majus in Romania." Acta Botanica Croatica 77, no. 2 (2018): 189–92. http://dx.doi.org/10.2478/botcro-2018-0015.

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Abstract The sexual morph (chasmothecium) of Erysiphe macleayae on Chelidonium majus has been found in Romania for the first time. Although the asexual morph of this powdery mildew on C. majus is known from many countries, the occurrence of chasmothecia on this host is rather rare. A description of morphological characters and an analysis of the phylogenetic relationship of ITS sequences of the Romanian specimens are presented.

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Nawaz, Aisha, Amina Arif, Adil Jamal, Muhammad Naveed Shahid, Ibtesam Nomani, and Fayez Saeed Bahwerth. "Medicinal plants show remarkable antiproliferative potential in human cancer cell lines." Bioscience, Biotechnology, and Biochemistry 86, no. 3 (2022): 362–67. http://dx.doi.org/10.1093/bbb/zbab225.

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ABSTRACT Molecules isolated and identified from plant origin are used to manufacture most chemotherapeutic drugs for cancer treatment. We assumed that these plant extracts contain prolific bioactive compounds with potent antiproliferative activities and could be effective against different human cancer cells. Ethanolic extracts were prepared from Chelidonium majus, Myrica cerifera, Fumaria indica, Nigella sativa, and Silybum marianum, and the antiproliferative assay was performed in HepG2 and HeLa human cancer cell lines. All plants extract exhibited antiproliferative potential against studied

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Paulsen, Jana, Mahdi Yahyazadeh, Sophie Hänsel, Maik Kleinwächter, Kerstin Ibrom, and Dirk Selmar. "13,14-Dihydrocoptisine - The genuine alkaloid from Chelidonium majus." Phytochemistry 111 (March 31, 2015): 149–53. https://doi.org/10.1016/j.phytochem.2015.01.006.

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Paulsen, Jana, Yahyazadeh, Mahdi, Hänsel, Sophie, Kleinwächter, Maik, Ibrom, Kerstin, Selmar, Dirk (2015): 13,14-Dihydrocoptisine - The genuine alkaloid from Chelidonium majus. Phytochemistry 111: 149-153, DOI: 10.1016/j.phytochem.2015.01.006, URL: http://dx.doi.org/10.1016/j.phytochem.2015.01.006

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Wu, Cuiting, Xin Wang, Ming Xu, Youping Liu, and Xin Di. "Intracellular Accumulation as an Indicator of Cytotoxicity to Screen Hepatotoxic Components of Chelidonium majus L. by LC–MS/MS." Molecules 24, no. 13 (2019): 2410. http://dx.doi.org/10.3390/molecules24132410.

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A novel strategy was developed to identify hepatotoxic compounds in traditional Chinese medicines (TCMs). It is based on the exposure of HL-7702 cells to a TCM extract, followed by the identification and further determination of potential hepatotoxic compounds accumulated in the cells by liquid chromatography–tandem mass spectrometry (LC–MS/MS). As a case study, potential hepatotoxic components in Chelidonium majus L. were screened out. Five alkaloids (sanguinarine, coptisine, chelerythrine, protopine, and chelidonine) were identified by LC–MS/MS within 10 min, and their intracellular concentr

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El-Readi, Mahmoud Zaki, SafaaYehia Eid, Mohamed Lotfy Ashour, Ahmad Tahrani, and Michael Wink. "Modulation of multidrug resistance in cancer cells by chelidonine and Chelidonium majus alkaloids." Phytomedicine 20, no. 3-4 (2013): 282–94. http://dx.doi.org/10.1016/j.phymed.2012.11.005.

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Zwerger, Michael, Lynda Boeck, Julia Manzl, Stefan Schwaiger, and Markus Ganzera. "Novel Approaches for the Analysis and Isolation of Benzylisoquinoline Alkaloids in Chelidonium majus." Planta Medica 90, no. 07/08 (2024): 523–33. http://dx.doi.org/10.1055/a-2204-5686.

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AbstractBenzylisoquinoline alkaloids are the major bioactive components in Chelidonium majus, a plant that has a long usage history for the treatment of gastrointestinal ailments in European and Asian phytomedicine. This study reports on the development and application of a supercritical fluid chromatography technique for the simultaneous qualitative and quantitative determination of seven benzylisoquinoline alkaloids in under six minutes using a Viridis BEH 2-EP column and a modifier comprising methanol with 30% acetonitrile and 20 mM ammonium formate. The method was fully validated according

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Marunych, R. Yu. "Chelidonium majus WATER EXTRACT INITIATES PLATELET AGGREGATION AND INHIBITS FIBRIN POLYMERIZATION IN BLOOD PLASMA." Biotechnologia Acta 15, no. 3 (2022): 29–34. http://dx.doi.org/10.15407/biotech15.03.029.

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Chelidonium majus is a well-known source of biologically active compounds. Most of them are alkaloids, which are used in researches and for tradition medicine. In this study, we explored the influence of C. majus crude total extract onto blood coagulation system in vitro, primary and secondary hemostasis. Aim. To study influence of C. majus extract onto blood coagulation process. Methods. Turbidimetry of blood plasma, APTT test with chromogenic substrates, and platelet aggregation were used in the work. Results. We demonstrated moderate stimulating effect of the extract on platelets (the rate

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Sh.S., Achilova, Rabbimov A., and Ergashev SH.M. "Germination characteristics of greater celandine (CHELIDONIUM MAJUS L.) Seeds." American Journal Of Biomedical Science & Pharmaceutical Innovation 5, no. 2 (2025): 34–36. https://doi.org/10.37547/ajbspi/volume05issue02-09.

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This article presents the results of research conducted on the germination of Greater Celandine (Chelidonium majus L.), one of the valuable medicinal plant species. It was found that under laboratory conditions, seed germination was high (91.4-93%) with an optimal germination temperature of 25-30°C. Field germination, however, was relatively low (17.7-24.5%), influenced by the seeds' anatomical structure and variable environmental conditions.

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Kovalchuk, Halyna, Oksana Lupak, Halyna Klepach, and Ihor Polyuzhyn. "POTENTIOMETRIC DETERMINATION OF THE ANTIOXIDANT ACTIVITY OF MEDICINAL PLANTS." Scientific Journal of Polonia University 35, no. 4 (2019): 102–9. http://dx.doi.org/10.23856/3512.

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The article deals with the analysis of the existing methods of investigating the antioxidant activity of plants’ origin and the expediency of measuring oxidation-reduction potential for this purpose.The integral AOA of alcohol extracts Urtica dioica, Trifolium pretense, Chelidonium majus, Hippophae rhamnoides has been determined by potentiometric method using the mediator system. It was established that the leaves of sea – buckthorn are characterised by the highest antioxidant activity (2.05 ± 0.1 mg AA / ml). The АОА of plants Urtica dioica, Chelidonium majus, that were growing along the tran

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Gardin, N. E., S. A. Grines, and A. J. Braga. "Chelidonium majus and the image of COVID-19." Der Merkurstab 74, no. 5 (2021): 404–10. http://dx.doi.org/10.14271/dms-21406-en.

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Stickel, F., G. Pöschl, H. K. Seitz, R. Waldherr, E. G. Hahn, and D. Schuppan. "Acute Hepatitis Induced by Greater Celandine (Chelidonium majus)." Scandinavian Journal of Gastroenterology 38, no. 5 (2003): 565–68. http://dx.doi.org/10.1080/00365520310000942.

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Kirkilessi, Georgia, and Katerina Loukaki. "Therapie von Lebererkrankungen bei Haustieren mit Chelidonium majus." Zeitschrift für Ganzheitliche Tiermedizin 21, no. 3 (2007): 122–24. http://dx.doi.org/10.1055/s-2007-965559.

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Vinterhalter, B., and D. Vinterhalter. "Propagation of Chelidonium majus L. by Somatic Embryogenesis." Biologia plantarum 45, no. 4 (2002): 489–93. http://dx.doi.org/10.1023/a:1022360230668.

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Benninger, Johannes, H. Thomas Schneider, Detlef Schuppan, Thomas Kirchner, and Eckhart G. Hahn. "Acute hepatitis induced by greater celandine (Chelidonium majus)." Gastroenterology 117, no. 5 (1999): 1234–37. http://dx.doi.org/10.1016/s0016-5085(99)70410-5.

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Paulsen, Jana, Mahdi Yahyazadeh, Sophie Hänsel, Maik Kleinwächter, Kerstin Ibrom, and Dirk Selmar. "13,14-Dihydrocoptisine – The genuine alkaloid from Chelidonium majus." Phytochemistry 111 (March 2015): 149–53. http://dx.doi.org/10.1016/j.phytochem.2015.01.006.

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Zielinska, Sylwia, Magdalena Wójciak-Kosior, Bartosz J. Płachno, Ireneusz Sowa, Maciej Włodarczyk, and Adam Matkowski. "Quaternary alkaloids in Chelidonium majus in vitro cultures." Industrial Crops and Products 123 (November 2018): 17–24. http://dx.doi.org/10.1016/j.indcrop.2018.06.062.

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