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Dissertations / Theses on the topic 'Chemical entity'

Author: Grafiati

Published: 7 June 2025

Last updated: 2 August 2025

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1

Herrmann, Andrea [Verfasser]. "Comparison of a global submission of new biological entity and a new chemical entity – strategic decisions and criteria for implementation / Andrea Herrmann." Bonn : Universitäts- und Landesbibliothek Bonn, 2011. http://d-nb.info/101615612X/34.

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2

Batista-Navarro, Riza Theresa Bautista. "Information extraction from pharmaceutical literature." Thesis, University of Manchester, 2014. https://www.research.manchester.ac.uk/portal/en/theses/information-extraction-from-pharmaceutical-literature(3f8322b6-8b8d-44eb-a8cd-899026b267b9).html.

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With the constantly growing amount of biomedical literature, methods for automatically distilling information from unstructured data, collectively known as information extraction, have become indispensable. Whilst most biomedical information extraction efforts in the last decade have focussed on the identification of gene products and interactions between them, the biomedical text mining community has recently extended their scope to capture associations between biomedical and chemical entities with the aim of supporting applications in drug discovery. This thesis is the first comprehensive st

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3

Chen, Guohua 1963. "Impingement heat transfer with re-entry channel nozzles." Thesis, McGill University, 1989. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=59261.

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Intensity of axial turbulence at the nozzle exit and impingement heat transfer rate were measured for the re-entry slot channel nozzle, with nozzle length, L, nozzle width, w, and jet Reynolds number, Re, as parameters. With increasing Reynolds number over the range 5000-20000 the turbulence intensity decreases, but only slightly. For the shortest nozzles, i.e. orifices, turbulence varies greatly across the nozzle width, from 0% near the nozzle walls. A nozzle length of 3w-4w is sufficient to produce relatively flat profiles. Turbulence intensity is better characterized at the mid-plane, I$ s

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4

Jain, Surbhi. "Role of Disulfide Bond Rearrangement in Newcastle Disease Virus Entry: A Dissertation." eScholarship@UMMS, 2008. https://escholarship.umassmed.edu/gsbs_diss/379.

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Newcastle disease virus (NDV), an avian paramyxovirus, enters the host cell by fusion of viral and host cell membranes. The fusion of two membranes is mediated by the viral fusion (F) protein. The F protein, like other class I fusion proteins, is thought to undergo major conformational changes during the fusion process. The exact mechanism that leads to major refolding of F protein is not clear. Recently, it has been proposed that disulfide bond reduction in the fusion protein of some viruses may be involved in the conformational changes in fusion proteins. In some viruses, the reduction of di

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5

Wu, Keng-Tung. "Bubble coalescence from multiple entry nozzles in fluidized beds." Thesis, University College London (University of London), 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.286488.

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6

Elkhatib, Tarek Naim. "Design and operation of a dual-entry laser chemical vapor deposition rapid prototyping system." Thesis, Georgia Institute of Technology, 2002. http://hdl.handle.net/1853/17705.

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7

Wills, Susan Eileen 1965. "Personality characteristics of chemically dependent persons in a nontraditional, long-term re-entry program." Thesis, The University of Arizona, 1991. http://hdl.handle.net/10150/277889.

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The purpose of this study was to determine if persons with a history of chemical dependency have personality traits that differ from a norm group and to determine if personality traits are associated with the perceived level of recovery facilitation. Thirty-one subjects volunteered to fill out the research instruments (16 Personality Factor Questionnaire and a Self-Rated Perceived Level of Recovery Facilitation Scale). The results indicated that persons with a history of substance abuse are significantly more cool, shrewd, dominant, and undisciplined in self conflict, than the norm population.

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8

DAL, BIANCO ALESSANDRA. "Modeling and Numerical Simulation of the Behavior of Charring Ablators During Atmospheric Re-Entry." Doctoral thesis, Politecnico di Torino, 2013. http://hdl.handle.net/11583/2541908.

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During the atmospheric entry of a blunt body, a bow shock wave is generated on the nose of the vehicle, originating a zone at the wall where gaseous species are in thermochemical non-equilibrium. In fact, the large kinetic energy of the flow is converted through the shock into internal energy causing an increase in temperature, especially close to the nose. The temperature rise occurring near the stagnation region may excite the vibrational energy of the gas molecules and may also lead to dissociation and even to ionization. Thus, a hypersonic flow is frequently a chemically reacting flow. Ano

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9

Martin, Benlloch Xavier. "Synthesis and physico-chemical study of a novel flavone antiviral lead." Thesis, Strasbourg, 2015. http://www.theses.fr/2015STRAF002/document.

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Le travail de recherche présenté dans ce mémoire de thèse a été centré sur une nouvelle famille de flavones aux propriétés antivirales. Mon travail de thèse avait pour premier objectif d'améliorer la synthèse de la ladanéine (tête de série) et permettre l'accès à d’autres analogues. Un développement méthodologique a permis de mettre au point une synthèse compatible avec les procédés industriels qui permette d'améliorer les rendements et de raccourcir significativement les délais d'obtention. De plus, aucune purification par colonne de silice n’est nécessaire. Une étude physico-chimique détaill

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10

Thakkar, Jay N. "DISCOVERY OF LIGNIN SULFATE AS A POTENT INHIBITOR OF HSV ENTRY INTO CELLS." VCU Scholars Compass, 2006. http://scholarscompass.vcu.edu/etd/711.

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The herpes virus family consists of more than hundred members that infect organisms, of which eight, differing markedly in the biology are known to infect humans. HSV- I is the most common one, causing oral lesions and sporadic encephalitis. These infections are highly prevalent affecting at least one in three individuals in the United States.The entry of the herpes virus into the cell is a two-step process. The initial step involves the cell surface heparan sulfate and glycoproteins in the viral envelope which enables the virus to penetrate into the cell. The second step is the fusion step. D

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11

Morrison, Jordan T., Ralph A. Lugo, Jim C. Thigpen, and Stacy D. Brown. "Stability of Extemporaneously Prepared Lansoprazole Suspension at Two Temperatures." Digital Commons @ East Tennessee State University, 2013. https://dc.etsu.edu/etsu-works/5315.

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OBJECTIVE The purpose of this study was to examine the stability of a generic lansoprazole product in a 3 mg/mL sodium bicarbonate suspension under room temperature and refrigerated conditions. METHODS Lansoprazole suspensions (3 mg/mL) were prepared in triplicate using an 8.4% sodium bicarbonate vehicle for each storage condition (room temperature and refrigerated). During 1 month, samples from each replicate were periodically removed and analyzed for lansoprazole concentration by liquid chromatography–tandem mass spectrometry (LC-MS/MS). Each sample was spiked with 10 mg/L omeprazole to serv

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12

Dougherty, Maximilian. "Numerical Simulations of Reacting Flow in an Inductively Coupled Plasma Torch." ScholarWorks @ UVM, 2015. http://scholarworks.uvm.edu/graddis/512.

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In the design of a thermal protection system for atmospheric entry, aerothermal heating presents a major impediment to efficient heat shield design. Recombination of atomic species in the boundary layer results in highly exothermic surface-catalyzed recombination reactions and an increase in the heat flux experienced at the surface. The degree to which these reactions increase the surface heat flux is partly a function of the heat shield material. Characterization of the catalytic behavior of these materials takes place in experimental facilities, however there is a dearth of detailed computat

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13

Barhoum, Patrick. "Synthèse et caractérisations de nouvelles sondes fluorescentes et réactifs chimiques pour l'étude structurale de l'ARN." Phd thesis, Université de Strasbourg, 2013. http://tel.archives-ouvertes.fr/tel-00998937.

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L'étude de la structure de l'ARN est reconnue un sujet d'actualité qui permet de connaître sa fonction. Il existe différentes techniques enzymatiques ou chimiques classiques et récentes couplées au séquençage à haut débit pour étudier la structure de l'ARN. Le projet de thèse vise l'optimisation de deux techniques de cartographie déjà existantes et se divise en deux parties. La première partie concerne l'optimisation de la technique de hSHAPE et ceci en synthétisant de nouvelles sondes fluorescentes à transfert d'énergie capables d'étudier de faibles quantités d'ARN et adaptées au séquenceur d

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14

Ko, Cathy, and 柯雅真. "The Analysis of Entry Strategy- in Everlight Chemical Industrial Corporation." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/5uh89u.

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碩士<br>國立臺北商業大學<br>國際商務系碩士班<br>103<br>Chemical industry is a traditional industry which developed in early century. Also, it's the essential industry of economic development for recently decades. In addition, SMEs are the important role for domestic economics, and we can find SMEs family business occupied the maximum. Under the trend of globalization, enterprise face the challenge that how to maintain the competitive advantage, it is a great urgency for the said industry to develop the new market. This study used qualitative research, and the main purpose of this study is to explore market entr

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15

Barros, Tiago Rudolfo Silva D’Oliveira. "Chemical and structural aspects of Ebolavirus sp. cell entry inhibitors." Master's thesis, 2016. http://hdl.handle.net/10451/34503.

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Trabalho Final de Mestrado Integrado, Ciências Farmacêuticas, Universidade de Lisboa, Faculdade de Farmácia, 2016<br>O vírus Ébola esteve na origem do surto ocorrido em 2014 resultando numa epidemia de proporções históricas na África ocidental. Constituem uma família de vírus denominada Filoviridae que inclui cinco estirpes virais e são responsáveis por infeções cujo sintoma principal são febres hemorrágicas graves. Nesta família de vírus está inserido o Ebolavirus sp.,agente causal da epidemia em questão, associado a taxas de mortalidade até 90%, tendo se tornado assim num grande foco de aten

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16

Pan, Hsuan-Heng, and 潘鉉衡. "A Study of Entire Improvement for Kaolinite Using Electro-Osmotic Chemical Treatment." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/hukde6.

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碩士<br>國立臺灣科技大學<br>營建工程系<br>100<br>Previous studies indicated that the injection time of Calcium Chloride solution has large effects on the results of electro-osmotic chemical treatment. In particular, when the injection time is short, the improved soil strength in the vicinity of cathode will not be achieved. The longer injection time, on the other hand, will lead to the cementation near cathode, which, in turn, forms an impermeable layer around cathode and then prevents the injection of Sodium Silicate Solution. The thesis studies the injection time as the Sodium Silicate Solution is injected

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17

Yang, Tsey-Jiannn, and 楊子建. "Mergers and Acquisitions as Entry Mode Strategy for Developing Specialty Chemical Business in China." Thesis, 2002. http://ndltd.ncl.edu.tw/handle/63465571282521660506.

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碩士<br>國立臺灣大學<br>財務金融學研究所<br>90<br>Objective of this article is feasibility study for the two issues below: 1. Mergers and Acquisitions( M&A) as entry mode strategy for developing specialty chemical business in China; 2. Applying real options analysis( ROA) for M&A Valuation. It’s quite possible that foreign direct investment (FDI) will be on hot pace for M&A in China and gradually induce FDI toward cross-border M&A. The key driving forces are the China open-door policy, it’s focus on inviting FDI and gradual liberation after China’s WTO accession.

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18

(6617957), Yen H. Bui. "AUTOMATION OF THE VIRTUAL WORKBENCH: A PROTOCOL FOR THE ENTRY OF BIG DATA WITHIN A CHEMICAL DOMAIN." Thesis, 2020.

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<p>Here we describe recent technical implementations and modifications to the libefp package as well as applications of those implementations. Applications of the EFP method to biologically relevant systems are provided on a benchmark EFP-SAPT-CCSD study on the SSI dataset along with suggested basis set recommendations and a study on the pairwise EFP total energy decomposition on Factor Xa. We also report the technical overview of two computational tools we believe will lower the human barrier to utilizing the EFP method - iSpiEFP and EFPdB.</p>

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19

Liang, Chi-Tsong, and 梁棋聰. "A Comparison of entry modes into the China and Taiwan markets - using chemical company X as an example." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/19506162424235171719.

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碩士<br>國立中山大學<br>國際高階經營管理碩士班<br>92<br>A widely respected consultancy firm predicts that the amount of FDI (Foreign Direct Investment) into the petrochemical sector in China will reach USD 30 billion between 2000 and 2005. If we consider the huge investments in China announced by several renowned petrochemical MNCs (multinationals) such as BP, Exxon Mobil and Shell, we can quickly conclude that the chemical market in China has become one of the most attractive for investments. In a similar way, Company X has also followed this trend and increased its investment more than 250 Million USD in Chi

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20

Kuo, Tzong-hsing, and 郭宗鑫. "Follower’s Strategy For High Entry-Barrier Industry - Case Study of Company A’s Strategy for LCD Chemicals." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/30349835328534645520.

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碩士<br>國立中山大學<br>高階經營碩士班<br>93<br>Abstract This dissertation explores the strategy of entering a high –barrier industry for a conventional resin company. By analyzing the competitive advantage of nations in LCD industry, followed by comparisons made based on Resources Based View among the leading LCD chemical companies and the emerging Korea chemical firms in this industry ,the author analyzed the key successful factors of these firms and assemblied a set of strategies for the local players. The results leads to conclusions as follows: 1. The Taiwan LCD industry will have limited future ,witho

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21

Novick, Steven Louis. "Chemical studies of viral entry mechanisms: I. Hydrophobic protein-lipid interactions during sendai virus membrane fusion. II. Kinetics of bacteriophage λ DNA injection". Thesis, 1990. https://thesis.library.caltech.edu/8609/1/Novick-sl-1990.pdf.

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<p> Viruses possess very specific methods of targeting and entering cells. These methods would be extremely useful if they could also be applied to drug delivery, but little is known about the molecular mechanisms of the viral entry process. In order to gain further insight into mechanisms of viral entry, chemical and spectroscopic studies in two systems were conducted, examining hydrophobic protein-lipid interactions during Sendai virus membrane fusion, and the kinetics of bacteriophage λ DNA injection.</p> <p> Sendai virus glycoprotein interactions with target membranes during the early s

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22

Gao, Li. "Theoretical and Experimental Investigations of Permeate Gap Membrane Distillation." Thesis, 2019. https://vuir.vu.edu.au/40061/.

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Membrane Distillation (MD) is a separation process driven by the vapour pressure difference established across hydrophobic membrane. In order to combine the advantages of conventional MD configurations, Permeate Gap Membrane Distillation (PGMD) modules were developed. The objectives of this study were to systematically evaluate the performance of several new hollow fibre PGMD modules. This study consisted of four components. First of all, the membrane was systematically characterized. The membrane dimension and morphology were investigated using Scanning Electron Microscope (SEM). The membran

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