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Relevant bibliographies by topics / Chemical Induced Toxicity / Dissertations / Theses

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Dissertations / Theses on the topic 'Chemical Induced Toxicity'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Lovatt, Cerys Ann. "The role of glutathione S-transferase Pi in chemical-induced toxicity." Thesis, University of Liverpool, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.412639.

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2

Kang, SooYeon. "HIGH-THROUGHPUT METABOLISM-INDUCED TOXICITY ASSAYS ON A 384-PILLAR PLATE." Cleveland State University / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=csu1530883608111352.

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3

Mehta, Darshan. "New Fragmentation Method to Enhance Structure-Based In Silico Modeling of Chemically-Induced Toxicity." The Ohio State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=osu1449759891.

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4

Rajanahalli, Krishnamurthy Pavan. "Toxicity Of Silver Nanoparticles In Mouse Embryonic Stem Cells And Chemical Based Reprogramming Of Somatic Cells To Sphere Cells." University of Dayton / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=dayton1327115925.

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5

Yang, Jianhua. "Protective action of metallothionein against chemically induced toxicity." HKBU Institutional Repository, 1999. http://repository.hkbu.edu.hk/etd_ra/185.

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6

Sauer, John-Michael. "All- trans-retinol modulation of chemically-induced pulmonary and hepatic toxicity." Diss., The University of Arizona, 1996. http://hdl.handle.net/10150/187501.

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It has been previously reported that acute hypervitaminosis A in rats dramatically increases the hepatotoxicity of a number of chemicals. This potentiation appears to be mediated by the enhanced release of reactive oxygen species from retinol-primed Kupffer cells. However, in the lung it has been shown that retinol can protect against many of the inflammatory effects caused by bleomycin. Whether or not retinol pretreatment can modulate chemical-induced injury of compounds that cause both liver and lung toxicity is unknown. Therefore, the studies presented here were designed to test the hypothe

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7

Smith, Bill J. "The role of epoxidation in 4-vinylcyclohexene-induced ovarian toxicity." Diss., The University of Arizona, 1990. http://hdl.handle.net/10150/185059.

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The basis for the species difference between B6C3F1 mice (susceptible) and Fischer 344 rats (resistant) to 4- vinylcyclohexene (VcH)-induced ovarian tumorigenicity was investigated. Greater than 95% of a single oral 400 mg/kg dose of [¹⁴C]VCH was eliminated in 48 hr by mice and rats. Approximately 50-60% of the administered dose was excreted in the urine, while the remaining 30-40% of the dose was expired as organically soluble radioactivity. VCH-treated mice had dramatically higher blood concentrations of the VCH metabolite VCH-1,2-epoxide compared to VCH-treated rats. Furthermore, mouse hepa

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8

Nahle, Sara. "Réponse macrophagique aux nanomatériaux carbonés : effets de leur caractéristiques physiques et chimiques sur le transcriptome Carbon-based nanomaterials induce inflammation and autophagy in rat alveolar macrophages Single wall and multiwall carbon nanotubes induce different toxicological responses in rat alveolar macrophages Gene expression profiling of alveolar macrophages exposed to non-functionalized, anionic or cationic multi-walled carbon nanotubes shows three different mechanisms of toxicity Cytotoxicity and global transcriptional responses induced by zinc oxide nanoparticles NM 110 in PMA-differentiated THP-1 cells Protein and lipid homeostasis altered in rat macrophages after exposure to metallic oxide nanoparticles." Thesis, Université de Lorraine, 2019. http://www.theses.fr/2019LORR0142.

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Les nanomatériaux carbonés (NMC) sont très utilisés dans le monde industriel et leurs applications, nombreuses, sont en plein développement. L’absence de réglementation pour leur préparation et leur emploi fait qu’il est nécessaire comme pour tous les nano-objets, de déterminer le risque qu’une exposition fait courir à l’Homme et d’adapter la législation en conséquence. Une meilleure connaissance de leur potentiel toxique est donc nécessaire. Les difficultés de plus en plus grandes pour utiliser les modèles animaux, rend nécessaire le développement d’études avec des lignées cellulaires au sein

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9

Galdones, Eugene. "The role of retinoic acid receptor gamma in retinoid-induced limb dysmorphogenesis /." Thesis, McGill University, 2009. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=115711.

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Retinol (vitamin A) and its active metabolite, all-trans retinoic acid, signal through nuclear retinoic acid and retinoid X receptor (RAR/RXR) heterodimers. These complexes regulate the expression of genes involved in developmental processes such as limb development. In excess, retinoids are potent teratogens and cause marked reductive effects on the developing limb. The goal of this thesis was to elucidate the molecular mechanisms underlying retinoid-induced limb dysmorphogenesis. Specifically, using an in vitro limb culture system, I examined the involvement of one RAR isoform, RARgamma, in

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10

Campbell, Holly R. 1976. "Chlorine-induced lung injury and the role of iNOS." Thesis, McGill University, 2009. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=111574.

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Reactive airways dysfunction syndrome (RADS), a form of irritant-induced asthma (IIA) has been observed in humans following acute chlorine (Cl 2) gas exposure in occupational and domestic settings. Following Cl 2 injury, subepithelial fibrosis, mucous hyperplasia, and non-specific airway hyperresponsiveness have been reported. Based on the disease profile, we hypothesized that pulmonary damage may be oxidative in nature.<br>The aim of this work was to develop a murine model of irritant-induced asthma in order to investigate the pathogenic processes and potential oxidative mechanisms involved i

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11

Dyck, Richard Henry. "Cytochrome oxidase histopathology in the central nervous system of developing rats displaying methylmercury-induced movement and postural disorders." Thesis, University of British Columbia, 1988. http://hdl.handle.net/2429/27873.

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Sprague-Dawley rats were administered daily, subcutaneous injections of methylmercuric chloride at a dose of 5 mg/Hg/kg beginning on postnatal day 5. By their fourth postnatal week, animals exhibited a constellation of neurological signs of motor impairment which resembled the cerebral palsy syndrome of humans perinatally exposed to methylmercury. Routine histological examination of the brain revealed no gross differences between methylmercury-treated (MeHg), normal control (NC) or weight-matched littermates. The histochemical localization of the mitochondrial enzyme cytochrome oxidase (CO) w

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12

Srđan, Živojinov. "Razvoj animalnog modela nefrotoksične tubulointersticijalne lezije." Phd thesis, Univerzitet u Novom Sadu, Medicinski fakultet u Novom Sadu, 2016. http://www.cris.uns.ac.rs/record.jsf?recordId=99867&source=NDLTD&language=en.

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U eksperimantalnom postupku disertacije mi&scaron;evi NMRI soja su tretirani infuzom biljke Aristolochia clematitis. Sasu&scaron;eni listovi, grane i plodovi biljke potopljeni su u ključalu vodu i ostavljeni 3-5 sati da stoje, a potom su profiltrirani kroz filter papir. Pravljen je rastvor biljke/vode od 10g/ 1000ml (1%), 20g/ 1000ml (2%) i 40g/ 1000ml (4%). Različite koncentracije infuza su date mi&scaron;evima da piju u neograničenoj količini u periodu od 7 nedelja. Tako su formirane tri ispitne grupe, prva koja je primala 1% infuz, druga 2% infuz i treća 4% infuz i kontrolna grupa koja je d

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13

Fló, Claudia Marina. "Efeito da atividade física sobre a evolução do enfisema pulmonar: um estudo experimental em ratos wistar." Universidade de São Paulo, 2003. http://www.teses.usp.br/teses/disponiveis/5/5160/tde-05092014-161209/.

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O propósito da presente investigação foi avaliar o papel da atividade física no desenvolvimento de enfisema induzido por papaína em ratos. Para tanto, ratos Wistar foram randomicamente divididos em quatro grupos (n = 10 para cada grupo) que receberam, respectivamente, infusão intra-traqueal de papaína (6 mg em 1 mL de NaCl 0,9%) ou veículo e foram submetidos ou não ao protocolo de exercício em uma esteira ergométrica. Os ratos exercitaram-se a 13,3 m/min, 6 dias por semana, durante 9 semanas (o tempo de exercício foi aumentado gradualmente, de 10 a 35 min). Foram medidas a elastância e a resis

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14

Watt, James. "Identifying and modeling the contribution of nuclear receptors to environmental obesogen-induced toxicity in bone." Thesis, 2016. https://hdl.handle.net/2144/19516.

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Bone is a dynamic tissue, where bone forming osteoblasts and bone resorbing osteoclasts maintain homeostasis. Research into bone toxicology has largely focused on pharmaceutical side effects adversely affecting bone development. However, many environmental toxicants can regulate bone homeostasis. Recently, the nuclear receptor peroxisome proliferator activated receptor gamma (PPARγ) has emerged as an important target of environmental toxicants. PPARγ dimerizes with the retinoid-X receptor alpha (RXRα), is a central transcription factor in adipogenesis, and in bone can transdifferentiate osteob

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15

Shan, Weiwei. "Peroxisome proliferator-activated receptor [beta] attenuates chemically-induced liver toxicity." 2007. http://etda.libraries.psu.edu/theses/approved/WorldWideIndex/ETD-2250/index.html.

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16

"Mechanism of glutamate induced neurotoxicity in retina of adult rats." 2000. http://library.cuhk.edu.hk/record=b6073231.

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Tingan Chen.<br>"March 2000."<br>Thesis (Ph.D.)--Chinese University of Hong Kong, 2000.<br>Includes bibliographical references (p. 100-142).<br>Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web.<br>Mode of access: World Wide Web.<br>Abstracts in English and Chinese.

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17

Dinis, João Paulo Pires. "Early remyelination in the murine model exposed to cuprizone: are there any behavioral alterations?" Master's thesis, 2017. http://hdl.handle.net/10316/81967.

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Trabalho de Projeto do Mestrado Integrado em Medicina apresentado à Faculdade de Medicina<br>A administração de cuprizona (CPZ) a ratinhos machos C57BL/6 durante 5 semanas induz desmielinização extensa e generalizada do sistema nervoso central semelhante à encontrada na Esclerose Múltipla (EM). Todavia, caso se termine a intoxicação, ocorrerá remielinização espontânea. Este fenómeno único associado à inexistência de uma resposta imune exuberante torna este modelo um dos mais utilizados para o estudo da remielinização associada à EM. Propusémo-nos a desvendar qual o fenótipo dos animais durante

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18

Laslo-Baker, Dionne. "Child Neurodevelopment following In Utero Exposure to Organic Solvents." Thesis, 2012. http://hdl.handle.net/1807/34778.

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BACKGROUND: Many women of reproductive age are employed in industries involving exposure to organic solvents. Animal toxicological studies and human case reports demonstrate that exposure to organic solvents can cause neuropsychological deficits in exposed offspring; however, there is limited data from prospective controlled human studies. OBJECTIVE: To compare neuropsychological functioning between children whose mothers were occupationally exposed to organic solvents during pregnancy with a non-exposed matched comparison group. METHODS: Participants were 48 women who had previously contact

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