Academic literature on the topic 'Chemical Neurostimulation'

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Journal articles on the topic "Chemical Neurostimulation"

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Azizi, Farouk, Hui Lu, Hillel J. Chiel, and Carlos H. Mastrangelo. "Chemical neurostimulation using pulse code modulation (PCM) microfluidic chips." Journal of Neuroscience Methods 192, no. 2 (2010): 193–98. http://dx.doi.org/10.1016/j.jneumeth.2010.07.011.

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Bhat, Ankita, Alexa R. Graham, Hemang Trivedi, Matthew K. Hogan, Philip J. Horner, and Anthony Guiseppi-Elie. "Engineering the ABIO-BIO interface of neurostimulation electrodes using polypyrrole and bioactive hydrogels." Pure and Applied Chemistry 92, no. 6 (2020): 897–907. http://dx.doi.org/10.1515/pac-2019-1107.

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AbstractFollowing spinal cord injury, the use of electrodes for neurostimulation in animal models has been shown to stimulate muscle movement, however, the efficacy of such treatment is impaired by increased interfacial impedance caused by fibrous encapsulation of the electrode. Sputter-deposited gold-on-polyimide electrodes were modified by potentiostatic electrodeposition of poly(pyrrole-co-3-pyrrolylbutyrate-conj-aminoethylmethacrylate): sulfopropyl methacrylate [P(Py-co-PyBA-conj-AEMA):SPMA] to various charge densities (0–100 mC/cm2) to address interfacial impedance and coated with a phosphoryl choline containing bioactive hydrogel to address biocompatibility at the ABIO-BIO interface. Electrodes were characterized with scanning electron microscopy (surface morphology), multiple-scan rate cyclic voltammetry (peak current and electroactive area), and electrochemical impedance spectroscopy (charge transfer resistance and membrane resistance). SEM analysis and electroactive area calculations identified films fabricated with a charge density of 50 mC/cm2 as well suited for neurostimulation electrodes. Charge transfer resistance demonstrated a strong inverse correlation (−0.83) with charge density of electrodeposition. On average, the addition of polypyrrole and hydrogel to neurostimulation electrodes decreased charge transfer resistance by 82 %. These results support the use of interfacial engineering techniques to mitigate high interfacial impedance and combat the foreign body response towards epidurally implanted neurostimulation electrodes.
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Yang, Li‐Zhuang, Wei Zhang, Wenjuan Wang, et al. "Neurostimulation: Neural and Psychological Predictors of Cognitive Enhancement and Impairment from Neurostimulation (Adv. Sci. 4/2020)." Advanced Science 7, no. 4 (2020): 2070022. http://dx.doi.org/10.1002/advs.202070022.

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Hossain, Mohammad Zakir, Hiroshi Ando, Shumpei Unno, and Junichi Kitagawa. "Targeting Chemosensory Ion Channels in Peripheral Swallowing-Related Regions for the Management of Oropharyngeal Dysphagia." International Journal of Molecular Sciences 21, no. 17 (2020): 6214. http://dx.doi.org/10.3390/ijms21176214.

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Oropharyngeal dysphagia, or difficulty in swallowing, is a major health problem that can lead to serious complications, such as pulmonary aspiration, malnutrition, dehydration, and pneumonia. The current clinical management of oropharyngeal dysphagia mainly focuses on compensatory strategies and swallowing exercises/maneuvers; however, studies have suggested their limited effectiveness for recovering swallowing physiology and for promoting neuroplasticity in swallowing-related neuronal networks. Several new and innovative strategies based on neurostimulation in peripheral and cortical swallowing-related regions have been investigated, and appear promising for the management of oropharyngeal dysphagia. The peripheral chemical neurostimulation strategy is one of the innovative strategies, and targets chemosensory ion channels expressed in peripheral swallowing-related regions. A considerable number of animal and human studies, including randomized clinical trials in patients with oropharyngeal dysphagia, have reported improvements in the efficacy, safety, and physiology of swallowing using this strategy. There is also evidence that neuroplasticity is promoted in swallowing-related neuronal networks with this strategy. The targeting of chemosensory ion channels in peripheral swallowing-related regions may therefore be a promising pharmacological treatment strategy for the management of oropharyngeal dysphagia. In this review, we focus on this strategy, including its possible neurophysiological and molecular mechanisms.
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Chung, Tsai-Wei, Chih-Ning Huang, Po-Chun Chen, Toshihiko Noda, Takashi Tokuda, and Jun Ohta. "Fabrication of Iridium Oxide/Platinum Composite Film on Titanium Substrate for High-Performance Neurostimulation Electrodes." Coatings 8, no. 12 (2018): 420. http://dx.doi.org/10.3390/coatings8120420.

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Electrode materials for neural stimulation have been widely investigated for implantable devices. Among them, iridium and iridium oxide are attractive materials for bio-interface applications due to their desirable stability, electrochemical performance, and biocompatibility. In this study, iridium oxide/platinum (IrOx/Pt) composite films were successfully fabricated on titanium substrates by chemical bath deposition and these films are expected to be used as biocompatible stimulation electrodes. We modified the film compositions to optimize the performances. In addition, these IrOx/Pt composite films were characterized before and after annealing by SEM and XRD. We also identified the hydrophilicity of these iridium oxide/platinum composite films by measuring contact angles. Finally, the charge storage capacities of these iridium oxide/platinum composite films were evaluated by an electrochemical workstation. As a result, the charge storage capacities of the iridium oxide/platinum composite films are largely increased, and this leads to a very efficient neurostimulation electrode. Additionally, we successfully demonstrated the chemical bath deposition of IrOx film on the surface of the bullet-shaped titanium microelectrode.
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Guerra, Joaquín, Hortensia Lema, Carlos Agra, Pedro Martínez, and Jesús Devesa. "Laryngeal Paralysis Recovered Two Years after a Head Trauma by Growth Hormone Treatment and Neurorehabilitation." Reports 4, no. 3 (2021): 19. http://dx.doi.org/10.3390/reports4030019.

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The aim of this study was to describe the cognitive and speech results obtained after growth hormone (GH) treatment and neurorehabilitation in a man who suffered a traumatic brain injury (TBI). Seventeen months after the accident, the patient was treated with growth hormone (GH), together with neurostimulation and speech therapy. At admission, the flexible laryngoscopy revealed that the left vocal cord was paralyzed, in the paramedian position, a situation compatible with a recurrent nerve injury. Clinical and rehabilitation assessments revealed a prompt improvement in speech and cognitive functions and, following completion of treatment, endoscopic examination showed recovery of vocal cord mobility. These results, together with previous results from our group, indicate that GH treatment is safe and effective for helping neurorehabilitation in chronic speech impairment due to central laryngeal paralysis, as well as impaired cognitive functions.
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Yang, Li‐Zhuang, Wei Zhang, Wenjuan Wang, et al. "Neural and Psychological Predictors of Cognitive Enhancement and Impairment from Neurostimulation." Advanced Science 7, no. 4 (2020): 1902863. http://dx.doi.org/10.1002/advs.201902863.

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Shkurko, Y. S. "Neurotechnologies and Proliferation of the Ideas of Neuroscience." Social Psychology and Society 8, no. 4 (2017): 32–42. http://dx.doi.org/10.17759/sps.2017080403.

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In the article the author analyzed the idea of neuroplasticity-human brain change throughout person life under pressure of social, economic, cultural, and other factors-as a source of the increasing interest in human brain studies and widespread of the ideas of neuroscience within the body of scientific knowledge and beyond the laboratories. An opportunity to influence on social behavior by chemical brain intervention and neurostimulation attracted the attention of the politicians, militaries and pharmacological companies. The idea of brain plasticity was also continued in novel interdisciplinary research areas-social cognitive and affective neuroscience, cultural neuroscience, neuroeconomics, neurosociology, and others. This whole positive trend has a flaw. The transition from neuroscience facts to its social applications sometimes accompanies by information loss and misinterpretation. This damaged neuroscience and lead to dissemination of false ideas, promoting ambiguous social activity, strengthening control over person by access to the information ‘encrypted’ on the neural level. The analysis also sheds light on the background of the discussed recently neuroethics issues.
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Yin, Pengfei, Yang Liu, Lin Xiao, and Chao Zhang. "Advanced Metallic and Polymeric Coatings for Neural Interfacing: Structures, Properties and Tissue Responses." Polymers 13, no. 16 (2021): 2834. http://dx.doi.org/10.3390/polym13162834.

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Neural electrodes are essential for nerve signal recording, neurostimulation, neuroprosthetics and neuroregeneration, which are critical for the advancement of brain science and the establishment of the next-generation brain–electronic interface, central nerve system therapeutics and artificial intelligence. However, the existing neural electrodes suffer from drawbacks such as foreign body responses, low sensitivity and limited functionalities. In order to overcome the drawbacks, efforts have been made to create new constructions and configurations of neural electrodes from soft materials, but it is also more practical and economic to improve the functionalities of the existing neural electrodes via surface coatings. In this article, recently reported surface coatings for neural electrodes are carefully categorized and analyzed. The coatings are classified into different categories based on their chemical compositions, i.e., metals, metal oxides, carbons, conducting polymers and hydrogels. The characteristic microstructures, electrochemical properties and fabrication methods of the coatings are comprehensively presented, and their structure–property correlations are discussed. Special focus is given to the biocompatibilities of the coatings, including their foreign-body response, cell affinity, and long-term stability during implantation. This review article can provide useful and sophisticated insights into the functional design, material selection and structural configuration for the next-generation multifunctional coatings of neural electrodes.
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Jones, Peter D., and Martin Stelzle. "Can Nanofluidic Chemical Release Enable Fast, High Resolution Neurotransmitter-Based Neurostimulation?" Frontiers in Neuroscience 10 (March 31, 2016). http://dx.doi.org/10.3389/fnins.2016.00138.

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Dissertations / Theses on the topic "Chemical Neurostimulation"

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Jones, Peter D. [Verfasser], and Dieter P. [Akademischer Betreuer] Kern. "Nanofluidic technology for chemical neurostimulation / Peter D. Jones ; Betreuer: Dieter P. Kern." Tübingen : Universitätsbibliothek Tübingen, 2017. http://d-nb.info/116731090X/34.

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Azizi, Farouk. "Microfluidic Chemical Signal Generation." Cleveland, Ohio : Case Western Reserve University, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=case1244664596.

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Thesis(Ph.D.)--Case Western Reserve University, 2009<br>Title from PDF (viewed on 2009-11-23) Department of Electrical Engineering Includes abstract Includes bibliographical references and appendices Available online via the OhioLINK ETD Center
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Books on the topic "Chemical Neurostimulation"

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Campos, Lucas, and Jason E. Pope. Peripheral Nerve Stimulation. Edited by Mehul J. Desai. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199350940.003.0033.

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Neuromodulation is the process of altering nerve impulses through electrical or chemical mechanisms. Peripheral nerve stimulation (PNS) is one of the most diverse and rapidly expanding areas of neuromodulation. The goal of this chapter is to increase awareness of the theory, basic science, and ongoing clinical indications of PNS. The use of PNS is a natural outgrowth from traditional methods of using neurostimulation in the spinal canal. Various disease states are theoretically amenable to PNS, including headache disorders such as migraine and cluster headache. Significant and specific risks, safety concerns, and adverse events are possible with PNS, particularly without a focus on prevention.
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