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Journal articles on the topic 'Chemistry, Physical. Biophysics, Medical. Biophysics, General'

Author: Grafiati

Published: 4 June 2021

Last updated: 15 February 2022

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1

Vlasov, Alexey V., Nina L. Maliar, Sergey V. Bazhenov, Evelina I. Nikelshparg, Nadezda A. Brazhe, Anastasiia D. Vlasova, Stepan D. Osipov, et al. "Raman Scattering: From Structural Biology to Medical Applications." Crystals 10, no. 1 (January 15, 2020): 38. http://dx.doi.org/10.3390/cryst10010038.

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This is a review of relevant Raman spectroscopy (RS) techniques and their use in structural biology, biophysics, cells, and tissues imaging towards development of various medical diagnostic tools, drug design, and other medical applications. Classical and contemporary structural studies of different water-soluble and membrane proteins, DNA, RNA, and their interactions and behavior in different systems were analyzed in terms of applicability of RS techniques and their complementarity to other corresponding methods. We show that RS is a powerful method that links the fundamental structural biology and its medical applications in cancer, cardiovascular, neurodegenerative, atherosclerotic, and other diseases. In particular, the key roles of RS in modern technologies of structure-based drug design are the detection and imaging of membrane protein microcrystals with the help of coherent anti-Stokes Raman scattering (CARS), which would help to further the development of protein structural crystallography and would result in a number of novel high-resolution structures of membrane proteins—drug targets; and, structural studies of photoactive membrane proteins (rhodopsins, photoreceptors, etc.) for the development of new optogenetic tools. Physical background and biomedical applications of spontaneous, stimulated, resonant, and surface- and tip-enhanced RS are also discussed. All of these techniques have been extensively developed during recent several decades. A number of interesting applications of CARS, resonant, and surface-enhanced Raman spectroscopy methods are also discussed.

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2

Boregowda, Satish, Rod Handy, Darrah Sleeth, and Naomi Riches. "Using Thermodynamic Degradation Approach to Quantify Human Stress Response." Journal of Thermodynamics 2017 (September 11, 2017): 1–5. http://dx.doi.org/10.1155/2017/7546823.

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The present study provides a thermodynamic degradation approach to model human stress response. Finger skin temperature was used as an indicator of stress response to a stressor (or stressful event) followed by a recovery. The entropy change (ΔS) is calculated using heat transfer (δQ) from the peripheral skin and finger skin temperature (Tf). It was hypothesized that the human stress response, as evidenced by finger skin temperature change, is a quasi-static process. The entropy approach is demonstrated using data from a medical school experimental study. The finger skin temperature was measured under three conditions (relaxation, stressor task, and recovery) during the physiological test profile. The entropy change (ΔS) is postulated as entropy damage (ΔSD), which is a metric for measuring the aging or system degradation. The aging-ratio, Aaging-ratio, that is, the ratio of entropy change due to stressor to that of recovery, is presented for both male and female subjects. The statistical t-tests demonstrate statistical significance in human stress response to stressor and recovery states within and between male and female subjects. This novel approach could be valuable to medical researchers, particularly in the field of occupational health to evaluate human exposure to stressful environments.

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Boregowda, Satish, Rod Handy, Darrah Sleeth, and Andrew Merryweather. "Measuring Entropy Change in a Human Physiological System." Journal of Thermodynamics 2016 (February 22, 2016): 1–8. http://dx.doi.org/10.1155/2016/4932710.

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The paper presents a novel approach involving the use of Maxwell relations to combine multiple physiological measures to provide a measure of entropy change. The physiological measures included blood pressure (BP), heart rate (HR), skin temperature (ST), electromyogram (EMG), and electrodermal response (EDR). The multiple time-series physiological data were collected from eight subjects in an experimental pilot study conducted at the Human Engineering Laboratory of NASA Langley Research Center. The methodology included data collection during a relaxation period of eighteen minutes followed by a sixty-minute cognitive task. Two types of entropy change were computed: (a) entropy change (ΔSBP) due to blood pressure, heart rate, and skin temperature and (b) entropy change (ΔSEMG) due to electromyogram, electrodermal response, and skin temperature. The results demonstrate that entropy change provides a valuable composite measure of individual physiological response to various stressors that could be valuable in the areas of medical research, diagnosis, and clinical practice.

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Bünzli, Jean-Claude G. "Lanthanide light for biology and medical diagnosis." Journal of Luminescence 170 (February 2016): 866–78. http://dx.doi.org/10.1016/j.jlumin.2015.07.033.

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5

Bhadane, Mahesh S., Shahzad Akhtar, S. S. Dahiwale, K. Hareesh, K. Asokan, D. Kanjilal, V. N. Bhoraskar, and S. D. Dhole. "Evaluation of thermoluminescence of 200 keV carbon ion irradiated CaSO4:Dy nanophosphors for medical dosimetry." Journal of Luminescence 192 (December 2017): 695–700. http://dx.doi.org/10.1016/j.jlumin.2017.07.042.

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6

Glaser, R. "An Introduction of Biophysics with Medical Orientation." Bioelectrochemistry and Bioenergetics 28, no. 3 (October 1992): 499. http://dx.doi.org/10.1016/0302-4598(92)80043-g.

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Rontó, G. "BR 60 — An Introduction to Biophysics with Medical Orientation." Bioelectrochemistry and Bioenergetics 17, no. 3 (November 1987): 584–85. http://dx.doi.org/10.1016/0302-4598(87)80072-7.

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8

Bezzi, Georgina, Ernesto J. Piga, Andrés Binolfi, and Pablo Armas. "CNBP Binds and Unfolds In Vitro G-Quadruplexes Formed in the SARS-CoV-2 Positive and Negative Genome Strands." International Journal of Molecular Sciences 22, no. 5 (March 5, 2021): 2614. http://dx.doi.org/10.3390/ijms22052614.

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The Coronavirus Disease 2019 (COVID-19) pandemic has become a global health emergency with no effective medical treatment and with incipient vaccines. It is caused by a new positive-sense RNA virus called severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2). G-quadruplexes (G4s) are nucleic acid secondary structures involved in the control of a variety of biological processes including viral replication. Using several G4 prediction tools, we identified highly putative G4 sequences (PQSs) within the positive-sense (+gRNA) and negative-sense (−gRNA) RNA strands of SARS-CoV-2 conserved in related betacoronaviruses. By using multiple biophysical techniques, we confirmed the formation of two G4s in the +gRNA and provide the first evidence of G4 formation by two PQSs in the −gRNA of SARS-CoV-2. Finally, biophysical and molecular approaches were used to demonstrate for the first time that CNBP, the main human cellular protein bound to SARS-CoV-2 RNA genome, binds and promotes the unfolding of G4s formed by both strands of SARS-CoV-2 RNA genome. Our results suggest that G4s found in SARS-CoV-2 RNA genome and its negative-sense replicative intermediates, as well as the cellular proteins that interact with them, are relevant factors for viral genes expression and replication cycle, and may constitute interesting targets for antiviral drugs development.

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Reinsalu, Olavi, Anneli Samel, Elen Niemeister, and Reet Kurg. "MAGEA4 Coated Extracellular Vesicles Are Stable and Can Be Assembled In Vitro." International Journal of Molecular Sciences 22, no. 10 (May 14, 2021): 5208. http://dx.doi.org/10.3390/ijms22105208.

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Extracellular vesicles (EVs) are valued candidates for the development of new tools for medical applications. Vesicles carrying melanoma-associated antigen A (MAGEA) proteins, a subfamily of cancer-testis antigens, are particularly promising tools in the fight against cancer. Here, we have studied the biophysical and chemical properties of MAGEA4-EVs and show that they are stable under common storage conditions such as keeping at +4 °C and −80 °C for at least 3 weeks after purification. The MAGEA4-EVs can be freeze-thawed two times without losing MAGEA4 in detectable quantities. The attachment of MAGEA4 to the surface of EVs cannot be disrupted by high salt concentrations or chelators, but the vesicles are sensitive to high pH. The MAGEA4 protein can bind to the surface of EVs in vitro, using robust passive incubation. In addition, EVs can be loaded with recombinant proteins fused to the MAGEA4 open reading frame within the cells and also in vitro. The high stability of MAGEA4-EVs ensures their potential for the development of EV-based anti-cancer applications.

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10

Gardner, Kevin H. "Molecular biophysics at UT Southwestern Medical Center: Strength through breadth." Biopolymers 89, no. 4 (2008): 244–47. http://dx.doi.org/10.1002/bip.20927.

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Ishitsuka, Yosuke, and Dennis R. Roop. "Loricrin: Past, Present, and Future." International Journal of Molecular Sciences 21, no. 7 (March 25, 2020): 2271. http://dx.doi.org/10.3390/ijms21072271.

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The terminal differentiation of the epidermis is a complex physiological process. During the past few decades, medical genetics has shown that defects in the stratum corneum (SC) permeability barrier cause a myriad of pathological conditions, ranging from common dry skin to lethal ichthyoses. Contrarily, molecular phylogenetics has revealed that amniotes have acquired a specialized form of cytoprotection cornification that provides mechanical resilience to the SC. This superior biochemical property, along with desiccation tolerance, is attributable to the proper formation of the macromolecular protein-lipid complex termed cornified cell envelopes (CE). Cornification largely depends on the peculiar biochemical and biophysical properties of loricrin, which is a major CE component. Despite its quantitative significance, loricrin knockout (LKO) mice have revealed it to be dispensable for the SC permeability barrier. Nevertheless, LKO mice have brought us valuable lessons. It is also becoming evident that absent loricrin affects skin homeostasis more profoundly in many more aspects than previously expected. Through an extensive review of aggregate evidence, we discuss herein the functional significance of the thiol-rich protein loricrin from a biochemical, genetic, pathological, metabolic, or immunological aspect with some theoretical and speculative perspectives.

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12

Lenaz, G. "Biomembranes: Basic and Medical Research." Bioelectrochemistry and Bioenergetics 22, no. 3 (December 1989): 420. http://dx.doi.org/10.1016/0302-4598(89)87062-x.

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Gardner, Kevin H. "Erratum: “Molecular Biophysics at UT Southwestern Medical Center: Strength through breadth”." Biopolymers 89, no. 8 (2008): 710. http://dx.doi.org/10.1002/bip.21007.

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Makarov, Dmitrii E., and Benjamin Schuler. "Preface: Special Topic on Single-Molecule Biophysics." Journal of Chemical Physics 148, no. 12 (March 28, 2018): 123001. http://dx.doi.org/10.1063/1.5028275.

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Schlamadinger, Diana E., Dina I. Kats, and Judy E. Kim. "Quenching of Tryptophan Fluorescence in Unfolded Cytochromec: A Biophysics Experiment for Physical Chemistry Students." Journal of Chemical Education 87, no. 9 (September 2010): 961–64. http://dx.doi.org/10.1021/ed900029c.

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16

Stiers, Kyle M. "Personalized biophysics of human PGM1 deficiency." Acta Crystallographica Section A Foundations and Advances 73, a1 (May 26, 2017): a167. http://dx.doi.org/10.1107/s0108767317098348.

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17

Couture, Maxime, Sandy Shuo Zhao, and Jean-Francois Masson. "Modern surface plasmon resonance for bioanalytics and biophysics." Physical Chemistry Chemical Physics 15, no. 27 (2013): 11190. http://dx.doi.org/10.1039/c3cp50281c.

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18

Sorrin, Aaron J., Mustafa Kemal Ruhi, Nathaniel A. Ferlic, Vida Karimnia, William J. Polacheck, Jonathan P. Celli, Huang‐Chiao Huang, and Imran Rizvi. "Photodynamic Therapy and the Biophysics of the Tumor Microenvironment." Photochemistry and Photobiology 96, no. 2 (March 2020): 232–59. http://dx.doi.org/10.1111/php.13209.

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19

Jaminon, Armand, Koen Reesink, Abraham Kroon, and Leon Schurgers. "The Role of Vascular Smooth Muscle Cells in Arterial Remodeling: Focus on Calcification-Related Processes." International Journal of Molecular Sciences 20, no. 22 (November 14, 2019): 5694. http://dx.doi.org/10.3390/ijms20225694.

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Arterial remodeling refers to the structural and functional changes of the vessel wall that occur in response to disease, injury, or aging. Vascular smooth muscle cells (VSMC) play a pivotal role in regulating the remodeling processes of the vessel wall. Phenotypic switching of VSMC involves oxidative stress-induced extracellular vesicle release, driving calcification processes. The VSMC phenotype is relevant to plaque initiation, development and stability, whereas, in the media, the VSMC phenotype is important in maintaining tissue elasticity, wall stress homeostasis and vessel stiffness. Clinically, assessment of arterial remodeling is a challenge; particularly distinguishing intimal and medial involvement, and their contributions to vessel wall remodeling. The limitations pertain to imaging resolution and sensitivity, so methodological development is focused on improving those. Moreover, the integration of data across the microscopic (i.e., cell-tissue) and macroscopic (i.e., vessel-system) scale for correct interpretation is innately challenging, because of the multiple biophysical and biochemical factors involved. In the present review, we describe the arterial remodeling processes that govern arterial stiffening, atherosclerosis and calcification, with a particular focus on VSMC phenotypic switching. Additionally, we review clinically applicable methodologies to assess arterial remodeling and the latest developments in these, seeking to unravel the ubiquitous corroborator of vascular pathology that calcification appears to be.

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Kang, B. P. S., M. P. Bansal, and Uma Mehta. "Department of Biophysics, Panjab University, Chandigarh-160014, India." Biological Trace Element Research 77, no. 3 (2000): 231–40. http://dx.doi.org/10.1385/bter:77:3:231.

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21

Wüthrich, Kurt. "Nuclear magnetic resonance – from molecules to man." Quarterly Reviews of Biophysics 19, no. 1-2 (February 1987): 3–5. http://dx.doi.org/10.1017/s0033583500004005.

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Initial observations of the physical phenomenon of nuclear magnetic resonance (NMR) date back to the late 1940s. In the following two decades high-resolution NMR in solution became an indispensible analytical tool in chemistry, and solid state NMR had an increasingly important role in physics. Some of the potentialities of the method for investigations of complex biological systems had also long been anticipated, and initial experiments with biological specimens were described already 30 years ago. In practice, however, biological applications of NMR have become really attractive only during the last decade, following revolutionary advances in NMR instrumentation and the methodology for their use. NMR projects in biology and medicine now include studies of biomacromolecular structure and function, work on biological membranes, in vivo studies of biochemical processes, and imaging of macroscopic objects. Because of imminent practical applications in medical diagnosis and thanks to extensive coverage by the popular news media, interest in some of the recent developments spreads far beyond the scientific community, making NMR a widely popular field.

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22

Lakowicz, Joseph R., Ignacy Gryczynski, Valery Bogdanov, and Jozef Kusba. "Light quenching and fluorescence depolarization of rhodamine B and applications of this phenomenon to biophysics." Journal of Physical Chemistry 98, no. 1 (January 1994): 334–42. http://dx.doi.org/10.1021/j100052a055.

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23

Trifonov, S. V., V. V. Velichko, N. A. Tikhomirova, V. N. Shikhov, E. A. Morozov, and A. A. Tikhomirov. "Deep Physical-Chemical Purification of Gas Medium in Artificial Ecosystems." Doklady Biochemistry and Biophysics 492, no. 1 (May 2020): 112–16. http://dx.doi.org/10.1134/s1607672920030059.

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24

Wang, Tianqi, Weiwei Jin, Fuyou Liang, and Jordi Alastruey. "Machine Learning-Based Pulse Wave Analysis for Early Detection of Abdominal Aortic Aneurysms Using In Silico Pulse Waves." Symmetry 13, no. 5 (May 5, 2021): 804. http://dx.doi.org/10.3390/sym13050804.

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An abdominal aortic aneurysm (AAA) is usually asymptomatic until rupture, which is associated with extremely high mortality. Consequently, the early detection of AAAs is of paramount importance in reducing mortality; however, most AAAs are detected by medical imaging only incidentally. The aim of this study was to investigate the feasibility of machine learning-based pulse wave (PW) analysis for the early detection of AAAs using a database of in silico PWs. PWs in the large systemic arteries were simulated using one-dimensional blood flow modelling. A database of in silico PWs representative of subjects (aged 55, 65 and 75 years) with different AAA sizes was created by varying the AAA-related parameters with major impacts on PWs—identified by parameter sensitivity analysis—in an existing database of in silico PWs representative of subjects without AAAs. Then, a machine learning architecture for AAA detection was trained and tested using the new in silico PW database. The parameter sensitivity analysis revealed that the AAA maximum diameter and stiffness of the large systemic arteries were the dominant AAA-related biophysical properties considerably influencing the PWs. However, AAA detection by PW indexes was compromised by other non-AAA related cardiovascular parameters. The proposed machine learning model produced a sensitivity of 86.8 % and a specificity of 86.3 % in early detection of AAA from the photoplethysmogram PW signal measured in the digital artery with added random noise. The number of false positive and negative results increased with increasing age and decreasing AAA size, respectively. These findings suggest that machine learning-based PW analysis is a promising approach for AAA screening using PW signals acquired by wearable devices.

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25

Blakely, Eleanor A. "The 20th Gray lecture 2019: health and heavy ions." British Journal of Radiology 93, no. 1115 (November 1, 2020): 20200172. http://dx.doi.org/10.1259/bjr.20200172.

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Objective Particle radiobiology has contributed new understanding of radiation safety and underlying mechanisms of action to radiation oncology for the treatment of cancer, and to planning of radiation protection for space travel. This manuscript will highlight the significance of precise physical and biologically effective dosimetry to this translational research for the benefit of human health. This review provides a brief snapshot of the evolving scientific basis for, and the complex current global status, and remaining challenges of hadron therapy for the treatment of cancer. The need for particle radiobiology for risk planning in return missions to the Moon, and exploratory deep-space missions to Mars and beyond are also discussed. Methods Key lessons learned are summarized from an impressive collective literature published by an international cadre of multidisciplinary experts in particle physics, radiation chemistry, medical physics of imaging and treatment planning, molecular, cellular, tissue radiobiology, biology of microgravity and other stressors, theoretical modeling of biophysical data, and clinical results with accelerator-produced particle beams. Results Research pioneers, many of whom were Nobel laureates, led the world in the discovery of ionizing radiations originating from the Earth and the Cosmos. Six radiation pioneers led the way to hadron therapy and the study of charged particles encountered in outer space travel. Worldwide about 250,000 patients have been treated for cancer, or other lesions such as arteriovenous malformations in the brain between 1954 and 2019 with charged particle radiotherapy, also known as hadron therapy. The majority of these patients (213,000) were treated with proton beams, but approximately 32,000 were treated with carbon ion radiotherapy. There are 3500 patients who have been treated with helium, pions, neon or other ions. There are currently 82 facilities operating to provide ion beam clinical treatments. Of these, only 13 facilities located in Asia and Europe are providing carbon ion beams for preclinical, clinical, and space research. There are also numerous particle physics accelerators worldwide capable of producing ion beams for research, but not currently focused on treating patients with ion beam therapy but are potentially available for preclinical and space research. Approximately, more than 550 individuals have traveled into Lower Earth Orbit (LEO) and beyond and returned to Earth. Conclusion Charged particle therapy with controlled beams of protons and carbon ions have significantly impacted targeted cancer therapy, eradicated tumors while sparing normal tissue toxicities, and reduced human suffering. These modalities still require further optimization and technical refinements to reduce cost but should be made available to everyone in need worldwide. The exploration of our Universe in space travel poses the potential risk of exposure to uncontrolled charged particles. However, approaches to shield and provide countermeasures to these potential radiation hazards in LEO have allowed an amazing number of discoveries currently without significant life-threatening medical consequences. More basic research with components of the Galactic Cosmic Radiation field are still required to assure safety involving space radiations and combined stressors with microgravity for exploratory deep space travel. Advances in knowledge The collective knowledge garnered from the wealth of available published evidence obtained prior to particle radiation therapy, or to space flight, and the additional data gleaned from implementing both endeavors has provided many opportunities for heavy ions to promote human health.

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Gillilan, Richard, Durgesh K. Rai, Robert Miller, Sol Gruner, Nozomi Ando, and Qingqiu Huang. "HP-Bio: high-pressure BioSAXS for deep life and extreme biophysics." Acta Crystallographica Section A Foundations and Advances 76, a1 (August 2, 2020): a136. http://dx.doi.org/10.1107/s0108767320098645.

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27

Berg, Hermann. "Magnetobiology—underlying physical problems." Bioelectrochemistry 59, no. 1-2 (April 2003): 131. http://dx.doi.org/10.1016/s1567-5394(03)00011-2.

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28

Jezierska, Karolina, Anna Sękowska, Wojciech Podraza, Helena Gronwald, and Magdalena Łukowiak. "The effect of ionising radiation on the physical properties of 3D-printed polymer boluses." Radiation and Environmental Biophysics 60, no. 2 (January 22, 2021): 377–81. http://dx.doi.org/10.1007/s00411-021-00892-z.

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AbstractIn recent years, a method for designing radiotherapy boluses using 3D printing technology has been established in the West Pomeranian Oncology Centre in Szczecin, Poland. The aim of the present study was to investigate whether the ionising radiation used in radiotherapy affects the physical properties of the printing material. Particularly, the purpose of this study was to determine the effect of a 60 Gy X-ray radiation dose on the hardness and dimensions of 3D-printed boluses. Four cuboids were printed on a Zortrax M200 printer with acrylonitrile–butadiene–styrene (ABS) polymer. All printed samples were exposed to 60 Gy of X-ray radiation delivered by a medical accelerator. After irradiation, changes in the hardness (using Vickers test) and dimensions of the prints were measured. The therapeutic X-ray dose had a minimal effect on the dimensions of the printed samples, resulting in a maximum contraction of only 0.4%. Changes of the hardness were not statistically significant. In conclusion, regarding the radiotherapy planning process, the application of this therapeutic X-ray dose does not significantly influence the hardness and dimensions of ABS-printed boluses.

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Thévenot, Daniel R., Klara Toth, Richard A. Durst, and George S. Wilson. "Electrochemical biosensors: recommended definitions and classification1International Union of Pure and Applied Chemistry: Physical Chemistry Division, Commission I.7 (Biophysical Chemistry); Analytical Chemistry Division, Commission V.5 (Electroanalytical Chemistry).1." Biosensors and Bioelectronics 16, no. 1-2 (January 2001): 121–31. http://dx.doi.org/10.1016/s0956-5663(01)00115-4.

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Randoll, Ulrich G. "Biomagnetic stimulation. “Proceedings of an international symposium on biomagnetic stimulation, July 15, 1991, Fukuoka, Japan”, a satellite meeting of the World congress on medical physics and biomedical engineering in Kyoto, Shoogo Ueno." Bioelectrochemistry and Bioenergetics 39, no. 1 (February 1996): 149–50. http://dx.doi.org/10.1016/s0302-4598(96)90029-x.

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Tuinier, R., P. Zoon, C. Olieman, M. A. Cohen Stuart, G. J. Fleer, and C. G. de Kruif. "Isolation and physical characterization of an exocellular polysaccharide." Biopolymers 49, no. 1 (January 1999): 1–9. http://dx.doi.org/10.1002/(sici)1097-0282(199901)49:1<1::aid-bip1>3.0.co;2-b.

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Stimpson, Donald I., and Victor A. Bloomfield. "Physical properties of rod-shaped molecules in solution." Biopolymers 24, no. 2 (February 1985): 387–402. http://dx.doi.org/10.1002/bip.360240207.

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Dias, R., F. Antunes, M. Miguel, S. Lindman, and B. Lindman. "DNA-lipid systems: A physical chemistry study." Brazilian Journal of Medical and Biological Research 35, no. 5 (May 2002): 509–22. http://dx.doi.org/10.1590/s0100-879x2002000500002.

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Heyer, J. "General and Applied Aspects of Halophilic Microorganisms." Bioelectrochemistry and Bioenergetics 28, no. 3 (October 1992): 497–98. http://dx.doi.org/10.1016/0302-4598(92)80041-e.

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Astumian, R. D. "Bioelectrochemistry principles and practice Vol. I, Bioelectrochemistry: General introduction." Bioelectrochemistry and Bioenergetics 39, no. 2 (March 1996): 313. http://dx.doi.org/10.1016/s0302-4598(96)90001-x.

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Desamero, Ruel Z. B., Hu Cheng, Sean Cahill, Mark Girvin, Hua Deng, Robert Callender, Parshuram Rath, Bruce Variano, and John E. Smart. "Physical properties of compounds promoting oral delivery of macromolecular drugs." Biopolymers 67, no. 1 (2002): 26–40. http://dx.doi.org/10.1002/bip.10039.

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Tan, Pan, Juan Huang, Eugene Mamontov, Victoria García Sakai, Franci Merzel, Zhuo Liu, Yiyang Ye, and Liang Hong. "Decoupling between the translation and rotation of water in the proximity of a protein molecule." Physical Chemistry Chemical Physics 22, no. 32 (2020): 18132–40. http://dx.doi.org/10.1039/d0cp02416c.

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Simons, Elizabeth R. "The Blout Laboratory at Harvard Medical School from 1957 to 1972." Biopolymers 89, no. 5 (2008): 336–37. http://dx.doi.org/10.1002/bip.20922.

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Tuinier, R., W. H. M. van Casteren, P. J. Looijesteijn, H. A. Schols, A. G. J. Voragen, and P. Zoon. "Effects of structural modifications on some physical characteristics of exopolysaccharides fromLactococcus lactis." Biopolymers 59, no. 3 (September 2001): 160–66. http://dx.doi.org/10.1002/1097-0282(200109)59:3<160::aid-bip1015>3.0.co;2-v.

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Lee, B. "The physical origin of the low solubility of nonpolar solutes in water." Biopolymers 24, no. 5 (May 1985): 813–23. http://dx.doi.org/10.1002/bip.360240507.

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Choo-Smith, L. P., H. G. M. Edwards, H. P. Endtz, J. M. Kros, F. Heule, H. Barr, J. S. Robinson, H. A. Bruining, and G. J. Puppels. "Medical applications of Raman spectroscopy: From proof of principle to clinical implementation." Biopolymers 67, no. 1 (2002): 1–9. http://dx.doi.org/10.1002/bip.10064.

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Owicki, John C., and J. Wallace Parce. "Biosensors based on the energy metabolism of living cells: The physical chemistry and cell biology of extracellular acidification." Biosensors and Bioelectronics 7, no. 4 (1992): 255–72. http://dx.doi.org/10.1016/0956-5663(92)87004-9.

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Melillo, Jorge H., Jan Philipp Gabriel, Florian Pabst, Thomas Blochowicz, and Silvina Cerveny. "Dynamics of aqueous peptide solutions in folded and disordered states examined by dynamic light scattering and dielectric spectroscopy." Physical Chemistry Chemical Physics 23, no. 28 (2021): 15020–29. http://dx.doi.org/10.1039/d1cp01893k.

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Rahman, Mahmudur, Mohammad Julker Neyen Sampad, Aaron Hawkins, and Holger Schmidt. "Recent advances in integrated solid-state nanopore sensors." Lab on a Chip 21, no. 16 (2021): 3030–52. http://dx.doi.org/10.1039/d1lc00294e.

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Nanopores are powerful single molecule sensors that have a wide range of applications from single molecule biophysics to medical diagnostics. This review covers all aspects of nanopore sensor integration into increasingly complex lab-on-chip systems.

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Gabitto, Jorge F., and Costas Tsouris. "Physical Properties of Gas Hydrates: A Review." Journal of Thermodynamics 2010 (January 12, 2010): 1–12. http://dx.doi.org/10.1155/2010/271291.

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Methane gas hydrates in sediments have been studied by several investigators as a possible future energy resource. Recent hydrate reserves have been estimated at approximately 1016 m3 of methane gas worldwide at standard temperature and pressure conditions. In situ dissociation of natural gas hydrate is necessary in order to commercially exploit the resource from the natural-gas-hydrate-bearing sediment. The presence of gas hydrates in sediments dramatically alters some of the normal physical properties of the sediment. These changes can be detected by field measurements and by down-hole logs. An understanding of the physical properties of hydrate-bearing sediments is necessary for interpretation of geophysical data collected in field settings, borehole, and slope stability analyses; reservoir simulation; and production models. This work reviews information available in literature related to the physical properties of sediments containing gas hydrates. A brief review of the physical properties of bulk gas hydrates is included. Detection methods, morphology, and relevant physical properties of gas-hydrate-bearing sediments are also discussed.

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Yang, Kerong, Qing Han, Bingpeng Chen, Yuhao Zheng, Kesong Zhang, Qiang Li, and Jincheng Wang. "Antimicrobial hydrogels: promising materials for medical application." International Journal of Nanomedicine Volume 13 (April 2018): 2217–63. http://dx.doi.org/10.2147/ijn.s154748.

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Jayawant, Eleanor S., Jonathan D. Beadle, Ina Wilkening, Piotr Raubo, Michael Shipman, Rebecca Notman, and Ann M. Dixon. "Impact of oxetane incorporation on the structure and stability of alpha-helical peptides." Physical Chemistry Chemical Physics 22, no. 43 (2020): 25075–83. http://dx.doi.org/10.1039/d0cp03818k.

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Thiel, Brad L., Dennis D. Kunkel, and Christopher Viney. "Physical and chemical microstructure of spider dragline: A study by analytical transmission electron microscopy." Biopolymers 34, no. 8 (August 1994): 1089–97. http://dx.doi.org/10.1002/bip.360340812.

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Green, Ellen, Richard Ellis, and Peter Winlove. "The molecular structure and physical properties of elastin fibers as revealed by Raman microspectroscopy." Biopolymers 89, no. 11 (November 2008): 931–40. http://dx.doi.org/10.1002/bip.21037.

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Thoma, Johannes, and Björn M. Burmann. "Fake It ‘Till You Make It—The Pursuit of Suitable Membrane Mimetics for Membrane Protein Biophysics." International Journal of Molecular Sciences 22, no. 1 (December 23, 2020): 50. http://dx.doi.org/10.3390/ijms22010050.

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Membrane proteins evolved to reside in the hydrophobic lipid bilayers of cellular membranes. Therefore, membrane proteins bridge the different aqueous compartments separated by the membrane, and furthermore, dynamically interact with their surrounding lipid environment. The latter not only stabilizes membrane proteins, but directly impacts their folding, structure and function. In order to be characterized with biophysical and structural biological methods, membrane proteins are typically extracted and subsequently purified from their native lipid environment. This approach requires that lipid membranes are replaced by suitable surrogates, which ideally closely mimic the native bilayer, in order to maintain the membrane proteins structural and functional integrity. In this review, we survey the currently available membrane mimetic environments ranging from detergent micelles to bicelles, nanodiscs, lipidic-cubic phase (LCP), liposomes, and polymersomes. We discuss their respective advantages and disadvantages as well as their suitability for downstream biophysical and structural characterization. Finally, we take a look at ongoing methodological developments, which aim for direct in-situ characterization of membrane proteins within native membranes instead of relying on membrane mimetics.

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