Academic literature on the topic 'Chemo-profiling'

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Journal articles on the topic "Chemo-profiling"

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López, Isidoro, Julien Morey, Jean Bernard Ledeuil, Lénaïc Madec, and Hervé Martinez. "A critical discussion on the analysis of buried interfaces in Li solid-state batteries. Ex situ and in situ/operando studies." Journal of Materials Chemistry A 9, no. 45 (2021): 25341–68. http://dx.doi.org/10.1039/d1ta04532f.

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Rigorous approaches to study electro-chemo-mechanical processes at the analytically challenging buried interfaces in solid-state batteries are discussed. Furthermore, new experiments evidence potential misinterpretations in depth-profiling studies.
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Porciello, Nicla, Filippo Gallina, Giuseppe Frisullo, et al. "Spatial transcriptomics highlights B cells as key contributors to a complete and durable response to chemo-immunotherapy in a patient with resectable NSCLC." Journal for ImmunoTherapy of Cancer 13, no. 5 (2025): e011563. https://doi.org/10.1136/jitc-2025-011563.

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Neoadjuvant chemo-immunotherapy has significantly improved the treatment landscape for patients with ALK/EGFR wt resectable non-small cell lung cancer (NSCLC), offering novel opportunities for translational and clinical investigations. By leveraging deep molecular profiling through spatial transcriptomics integrated with single-cell RNA-sequencing from public atlases, and serum proteomic profiling, we report a case of a patient with resectable NSCLC and a solitary synchronous brain metastasis showing a complete pathologic response after chemo-immunotherapy, and a durable event-free survival. T
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Dey, Baishakhi, and Analava Mitra. "Chemo-profiling of eucalyptus and study of its hypoglycemic potential." World Journal of Diabetes 4, no. 5 (2013): 170. http://dx.doi.org/10.4239/wjd.v4.i5.170.

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Sufyani, Ohoud O., Magbool E. Oraiby, Ibraheem M. Attafi, et al. "Blood Chemo-Profiling in Workers Exposed to Occupational Pyrethroid Pesticides." International Journal of Environmental Research and Public Health 22, no. 5 (2025): 769. https://doi.org/10.3390/ijerph22050769.

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This study investigates the effect of occupational exposure to pyrethroid insecticides on the blood chemo-profiles of workers in the Jazan region. This study was conducted to examine this issue, and workers were divided into exposure groups based on how long they had been employed—from one to two years to more than eight years. Blood samples were analyzed to determine their hematological and biochemical parameters, and their chemo-profiles were assessed by GCMS analysis. Workers exposed for 8+ years had a 3.7 times higher risk of chronic diseases than those exposed for 1–2 years (p < 0.01).
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Sangar, Vineet, Mark Ricigliano, Eileen Mary O'Reilly, et al. "Use of pharmacogenomic modeling in pancreatic cancer for prediction of chemotherapy response and resistance." Journal of Clinical Oncology 31, no. 4_suppl (2013): 142. http://dx.doi.org/10.1200/jco.2013.31.4_suppl.142.

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142 Background: Pancreatic adenocarcinoma (PDAC) is uniformly lethal; despite this, modern cytotoxics (C) can induce tumor responses and extend life. Xenograft models have shown that pharmacogenomic (PGx) modeling of C can predict efficacy. Chemo-sensitivity and gene expression profiling of tumor progenitor (TP) cells isolated from peripheral blood may predict tumor response, progression and resistance. Methods: A prospective MSKCC study is ongoing with 46 of 60 planned patients accrued. 10 mL of peripheral blood is collected from patients with unresectable PDAC prior to C and at disease progr
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Yu, Kenneth H., Vineet Sangar, Mark Ricigliano, et al. "Use of pharmacogenomic modeling in pancreatic cancer for prediction of chemotherapy response and resistance." Journal of Clinical Oncology 31, no. 15_suppl (2013): 4017. http://dx.doi.org/10.1200/jco.2013.31.15_suppl.4017.

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4017 Background: Pancreatic adenocarcinoma (PDAC) is uniformly lethal and is the 4th leading cause of cancer mortality. Despite this, modern cytotoxics (C) can induce tumor responses and extend life. Xenograft models have shown that pharmacogenomic (PGx) modeling of C can predict efficacy. Chemo-sensitivity and gene expression profiling of circulating tumor and invasive cells (CTICs) isolated from peripheral blood may predict tumor response, progression and resistance. Methods: A prospective MSKCC study has completed planned accrual of 50 patients. 10 mL of peripheral blood is collected from p
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Schaffrin-Nabe, Dorthe, Tim Crook, Sewanti Limaye, et al. "Multidimensional tumor profiling and its meaningful impact on personalized therapy outcomes: Insights from a real-world study." Journal of Clinical Oncology 42, no. 16_suppl (2024): e15064-e15064. http://dx.doi.org/10.1200/jco.2024.42.16_suppl.e15064.

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e15064 Background: This real-world study underscores the transformative potential of multidimensional tumor profiling, including tissue and blood-based markers, in guiding personalized oncology treatments. We established a robust link between comprehensive diagnostics and improved clinical outcomes by correlating extensive profiling data with progression-free survival (PFS), the ratio of PFS2 to PFS1, and comparing these with treatment modalities. Methods: Over five years, 44 patients with advanced-stage solid tumors underwent comprehensive tumor profiling, including genetic markers from tissu
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Malik, Bisma, Tanveer Bilal Pirzadah, Inayatullah Tahir, and Reiaz Ul Rehman. "Chemo-profiling, Antioxidant Potential and Ionomic Analysis of Cichorium intybus L." Pharmacognosy Journal 9, no. 6 (2017): 917–28. http://dx.doi.org/10.5530/pj.2017.6.144.

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M, Mandira, Nataraj SK, M. Jadeyegowda, Hemanth Kumar P, and Shankar M. "Chemo-profiling of aqueous extract of Nauclea latifolia using GC-XX." International Journal of Advanced Biochemistry Research 8, no. 12S (2024): 292–94. https://doi.org/10.33545/26174693.2024.v8.i12sd.3130.

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Bhad, Vaishnavi, Dr Rathod, Dr AG Deshmukh, Dr Dipika Padole, Dr VS Kale, and Vaishnavi Zade. "Chemo-profiling of aqueous extract of Nauclea latifolia using GC-XX." International Journal of Advanced Biochemistry Research 8, no. 11S (2024): 43–46. http://dx.doi.org/10.33545/26174693.2024.v8.i11sa.2796.

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Conference papers on the topic "Chemo-profiling"

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Strand, C., M. Bak, S. Borgquist, et al. "Abstract P2-10-28: The Prognostic Index, KiGE, Combining Proliferation, Histological Grade and Estrogen Receptor Status Challenges Gene Profiling – A Study in 1,854 Chemo-Naïve Women with N0/N1 Primary Breast Cancer." In Abstracts: Thirty-Fifth Annual CTRC‐AACR San Antonio Breast Cancer Symposium‐‐ Dec 4‐8, 2012; San Antonio, TX. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/0008-5472.sabcs12-p2-10-28.

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Guerrero-Preston, Rafael E., James Robert White, Filipa Godoy-Vitorino, et al. "Abstract 1018: High-resolution microbiome profiling and genome wide arrays uncover bacteria driven alterations of oncogenic and immune pathways in head and neck cancer patients treated with surgery, chemo-radiation and PD-1 checkpoint blockade therapy." In Proceedings: AACR Annual Meeting 2017; April 1-5, 2017; Washington, DC. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1538-7445.am2017-1018.

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Guerrero-Preston, Rafael E., Kelvin Navarro, Filipa Godoy-Vitorino, et al. "Abstract 570: High-resolution microbiome profiling of 16SrRNA sequencing data, Microbiome Arrays, and expression arrays identifies differential bacterial communities in head and neck cancer patients treated with surgery, chemo-radiation, and PD-1 checkpoint blockade therapy." In Proceedings: AACR Annual Meeting 2018; April 14-18, 2018; Chicago, IL. American Association for Cancer Research, 2018. http://dx.doi.org/10.1158/1538-7445.am2018-570.

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Beljkas, Milan, Jelena Rebić, Milica Radan, Teodora Đikić, Slavica Oljačić, and Katarina Nikolic. "Virtual Docking, design and in silico ADMET profiling of novel Rho-associated protein kinases-1 (ROCK1) inhibitors." In 2nd International Conference on Chemo and Bioinformatics. Institute for Information Technologies, University of Kragujevac, 2023. http://dx.doi.org/10.46793/iccbi23.589b.

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Overexpression of Rho-associated protein kinases has been associated with various diseases, including tumors. None of the approved ROCK inhibitors are used for cancer treatment. However, some of them have been shown to have anti-tumor potential. The main objective of this study was to develop novel ROCK1 inhibitors using the structure-based method, molecular docking, and prediction of pharmacokinetic properties using the ADMET predictor. The key interactions that strongly correlate with the activity of ROCK1 inhibitors are hydrogen bonds between amino acid residues Met156, Glu154 and the hinge
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Pirić, David, and Romana Masnikosa. "Assessment of different machine learning tools employed in lipidomics." In 2nd International Conference on Chemo and Bioinformatics. Institute for Information Technologies, University of Kragujevac, 2023. http://dx.doi.org/10.46793/iccbi23.330p.

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Herein we present the potential of four machine learning (ML) algorithms: Partial Least Squares – Discriminant Analysis (PLS-DA), Random Forests (RF), Support Vector Machines (SVM) and Decision Trees (DT) to classify human plasma samples into cancer or control group, using a lipidomic dataset retrieved from the research article „Lipidomic profiling of human serum enables detection of pancreatic cancer“ by Wolrab et al. [1]. Our main objective was to assess and compare, for the four ML techniques, the performance metrics, that is accuracy, precision, sensitivity, F1 score and ROC-AUC, with thos
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Tomović, Jovica, Perica Vasiljević, Aleksandar Kočović, and Nedeljko Manojlović. "HPLC/UV profile and determination of total phenolic and flavonoid contents of lichen Umbilicaria crustulosa growing in Serbia." In 2nd International Conference on Chemo and Bioinformatics. Institute for Information Technologies, University of Kragujevac, 2023. http://dx.doi.org/10.46793/iccbi23.511t.

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The lichens synthesize a large number of secondary metabolites and most of these compounds are unique to lichen. The present study provides data concerning the chemical characterization and determination of total phenolic and flavonoid contents of lichen extracts of Umbilicaria crustulosa. Chemical profiling of the extracts was done by high-performance liquid chromatography coupled with a UV detector (HPLC/UV), while the determination of total phenolic and flavonoid contents was done by the spectrophotometric method. HPLC analysis of the acetone and methanol extracts of U. crustulosa lichen re
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