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Journal articles on the topic 'Chemo-profiling'

Author: Grafiati

Published: 4 June 2025

Last updated: 1 August 2025

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1

López, Isidoro, Julien Morey, Jean Bernard Ledeuil, Lénaïc Madec, and Hervé Martinez. "A critical discussion on the analysis of buried interfaces in Li solid-state batteries. Ex situ and in situ/operando studies." Journal of Materials Chemistry A 9, no. 45 (2021): 25341–68. http://dx.doi.org/10.1039/d1ta04532f.

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Rigorous approaches to study electro-chemo-mechanical processes at the analytically challenging buried interfaces in solid-state batteries are discussed. Furthermore, new experiments evidence potential misinterpretations in depth-profiling studies.

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Porciello, Nicla, Filippo Gallina, Giuseppe Frisullo, et al. "Spatial transcriptomics highlights B cells as key contributors to a complete and durable response to chemo-immunotherapy in a patient with resectable NSCLC." Journal for ImmunoTherapy of Cancer 13, no. 5 (2025): e011563. https://doi.org/10.1136/jitc-2025-011563.

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Neoadjuvant chemo-immunotherapy has significantly improved the treatment landscape for patients with ALK/EGFR wt resectable non-small cell lung cancer (NSCLC), offering novel opportunities for translational and clinical investigations. By leveraging deep molecular profiling through spatial transcriptomics integrated with single-cell RNA-sequencing from public atlases, and serum proteomic profiling, we report a case of a patient with resectable NSCLC and a solitary synchronous brain metastasis showing a complete pathologic response after chemo-immunotherapy, and a durable event-free survival. T

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Dey, Baishakhi, and Analava Mitra. "Chemo-profiling of eucalyptus and study of its hypoglycemic potential." World Journal of Diabetes 4, no. 5 (2013): 170. http://dx.doi.org/10.4239/wjd.v4.i5.170.

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Sufyani, Ohoud O., Magbool E. Oraiby, Ibraheem M. Attafi, et al. "Blood Chemo-Profiling in Workers Exposed to Occupational Pyrethroid Pesticides." International Journal of Environmental Research and Public Health 22, no. 5 (2025): 769. https://doi.org/10.3390/ijerph22050769.

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This study investigates the effect of occupational exposure to pyrethroid insecticides on the blood chemo-profiles of workers in the Jazan region. This study was conducted to examine this issue, and workers were divided into exposure groups based on how long they had been employed—from one to two years to more than eight years. Blood samples were analyzed to determine their hematological and biochemical parameters, and their chemo-profiles were assessed by GCMS analysis. Workers exposed for 8+ years had a 3.7 times higher risk of chronic diseases than those exposed for 1–2 years (p < 0.01).

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Sangar, Vineet, Mark Ricigliano, Eileen Mary O'Reilly, et al. "Use of pharmacogenomic modeling in pancreatic cancer for prediction of chemotherapy response and resistance." Journal of Clinical Oncology 31, no. 4_suppl (2013): 142. http://dx.doi.org/10.1200/jco.2013.31.4_suppl.142.

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142 Background: Pancreatic adenocarcinoma (PDAC) is uniformly lethal; despite this, modern cytotoxics (C) can induce tumor responses and extend life. Xenograft models have shown that pharmacogenomic (PGx) modeling of C can predict efficacy. Chemo-sensitivity and gene expression profiling of tumor progenitor (TP) cells isolated from peripheral blood may predict tumor response, progression and resistance. Methods: A prospective MSKCC study is ongoing with 46 of 60 planned patients accrued. 10 mL of peripheral blood is collected from patients with unresectable PDAC prior to C and at disease progr

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Yu, Kenneth H., Vineet Sangar, Mark Ricigliano, et al. "Use of pharmacogenomic modeling in pancreatic cancer for prediction of chemotherapy response and resistance." Journal of Clinical Oncology 31, no. 15_suppl (2013): 4017. http://dx.doi.org/10.1200/jco.2013.31.15_suppl.4017.

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4017 Background: Pancreatic adenocarcinoma (PDAC) is uniformly lethal and is the 4th leading cause of cancer mortality. Despite this, modern cytotoxics (C) can induce tumor responses and extend life. Xenograft models have shown that pharmacogenomic (PGx) modeling of C can predict efficacy. Chemo-sensitivity and gene expression profiling of circulating tumor and invasive cells (CTICs) isolated from peripheral blood may predict tumor response, progression and resistance. Methods: A prospective MSKCC study has completed planned accrual of 50 patients. 10 mL of peripheral blood is collected from p

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Schaffrin-Nabe, Dorthe, Tim Crook, Sewanti Limaye, et al. "Multidimensional tumor profiling and its meaningful impact on personalized therapy outcomes: Insights from a real-world study." Journal of Clinical Oncology 42, no. 16_suppl (2024): e15064-e15064. http://dx.doi.org/10.1200/jco.2024.42.16_suppl.e15064.

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e15064 Background: This real-world study underscores the transformative potential of multidimensional tumor profiling, including tissue and blood-based markers, in guiding personalized oncology treatments. We established a robust link between comprehensive diagnostics and improved clinical outcomes by correlating extensive profiling data with progression-free survival (PFS), the ratio of PFS2 to PFS1, and comparing these with treatment modalities. Methods: Over five years, 44 patients with advanced-stage solid tumors underwent comprehensive tumor profiling, including genetic markers from tissu

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Malik, Bisma, Tanveer Bilal Pirzadah, Inayatullah Tahir, and Reiaz Ul Rehman. "Chemo-profiling, Antioxidant Potential and Ionomic Analysis of Cichorium intybus L." Pharmacognosy Journal 9, no. 6 (2017): 917–28. http://dx.doi.org/10.5530/pj.2017.6.144.

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M, Mandira, Nataraj SK, M. Jadeyegowda, Hemanth Kumar P, and Shankar M. "Chemo-profiling of aqueous extract of Nauclea latifolia using GC-XX." International Journal of Advanced Biochemistry Research 8, no. 12S (2024): 292–94. https://doi.org/10.33545/26174693.2024.v8.i12sd.3130.

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Bhad, Vaishnavi, Dr Rathod, Dr AG Deshmukh, Dr Dipika Padole, Dr VS Kale, and Vaishnavi Zade. "Chemo-profiling of aqueous extract of Nauclea latifolia using GC-XX." International Journal of Advanced Biochemistry Research 8, no. 11S (2024): 43–46. http://dx.doi.org/10.33545/26174693.2024.v8.i11sa.2796.

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Beaton, Nigel, Marco Tognetti, Kamil Sklodowski, Roland Bruderer, and Lukas Reiter. "Abstract 5300: Mass spectrometry-based protein biomarker analysis in chemoimmunotherapy combinations identifies unique immune signatures in pancreatic cancer." Cancer Research 83, no. 7_Supplement (2023): 5300. http://dx.doi.org/10.1158/1538-7445.am2023-5300.

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Abstract Although the combination of chemotherapy with immunotherapy has led to significant improvements in the treatment of some solid tumors, metastatic pancreatic ductal adenocarcinoma (mPDAC) prognosis has remained largely unaffected by such approaches. Recently, PRINCE, a randomized phase 2 clinical study, reported significantly improved 1-year overall survival (OS) for mPDAC patients treated with nivolumab and chemotherapy (nivo/chemo) compared to historical control but not for sotigalimab and chemotherapy (sotiga/chemo) or a combination of the three. Interestingly, the study identified

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Shah, Neil J., David H. Aggen, Junting Zheng, et al. "HER2 mutation and bladder cancer (BC): Prevalence and clinical outcomes." Journal of Clinical Oncology 42, no. 4_suppl (2024): 574. http://dx.doi.org/10.1200/jco.2024.42.4_suppl.574.

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574 Background: Novel HER2-directed targeted therapies have revolutionized the treatment paradigm for patients with breast cancer and are being actively investigated in BC. The impact of pathogenic HER2 mutation and/or its amplification on clinical outcomes across various stages of BC is underdefined. Methods: In our retrospective study, we identified 999 BC patients who underwent genetic profiling using MSKCC IMPACT and had at least one year of follow-up. The BC disease states included non-muscle invasive (NMIBC), muscle-invasive (MIBC), and metastatic (MetBC). Patient demographics and HER2 a

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Homann, Arne, Malte Timm, and Jürgen Seibel. "Chemo-enzymatic synthesis and in vitro cytokine profiling of tailor-made oligofructosides." BMC Biotechnology 12, no. 1 (2012): 90. http://dx.doi.org/10.1186/1472-6750-12-90.

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Tong, Zhi-Bin, Ruili Huang, Yuhong Wang, et al. "The Toxmatrix: Chemo-Genomic Profiling Identifies Interactions That Reveal Mechanisms of Toxicity." Chemical Research in Toxicology 31, no. 2 (2017): 127–36. http://dx.doi.org/10.1021/acs.chemrestox.7b00290.

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Bruheim, S., Y. Xi, J. Ju, and O. Fodstad. "Chemo-response biomarker discovery via expression profiling using soft-tissue sarcoma xenografts." Journal of Clinical Oncology 24, no. 18_suppl (2006): 9569. http://dx.doi.org/10.1200/jco.2006.24.18_suppl.9569.

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9569 Background: Soft-tissue sarcoma (STS) constitute a heterogeneous group of tumours of mesenchymal origin. Whereas the mainstay of treatment has been surgery and radiation, these tumours are generally considered as quite chemoresistant. However, it is well known that subgroups of patients benefit from chemotherapy. Markers that could predict drug response would therefore be beneficial for the management of this malignancy. We have previously established panel of 17 unique human soft tissue xenografts, representing 7 different histological subgroups and assessed their responsiveness to doxor

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Piktel, Debbie, Rajesh R. Nair, Stephanie L. Rellick, et al. "Pitavastatin Is Anti-Leukemic in a Bone Marrow Microenvironment Model of B-Lineage Acute Lymphoblastic Leukemia." Cancers 14, no. 11 (2022): 2681. http://dx.doi.org/10.3390/cancers14112681.

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The lack of complete therapeutic success in the treatment of B-cell acute lymphoblastic leukemia (ALL) has been attributed, in part, to a subset of cells within the bone marrow microenvironment that are drug resistant. Recently, the cholesterol synthesis inhibitor, pitavastatin (PIT), was shown to be active in acute myeloid leukemia, prompting us to evaluate it in our in vitro co-culture model, which supports a chemo-resistant ALL population. We used phospho-protein profiling to evaluate the use of lipid metabolic active compounds in these chemo-resistant cells, due to the up-regulation of mul

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Dhir, Hardika, Monica Choudhury, Ketki Patil, et al. "Interception of Signaling Circuits of Esophageal Adenocarcinoma Cells by Resveratrol Reveals Molecular and Immunomodulatory Signatures." Cancers 13, no. 22 (2021): 5811. http://dx.doi.org/10.3390/cancers13225811.

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Deregulation of signaling pathways due to mutations sets the cell on a path to neoplasia. Therefore, recent reports of increased mutations observed in esophageal tissue reflects the enhanced risk of tumor formation. In fact, adenocarcinoma of the esophagus has been on the rise lately. Increase in mortality due to a paucity of efficacious drugs for this cancer prompted us to discover molecular signatures to combat this malady. To this end, we chose resveratrol—a polyphenol with anticancer property—and studied its impact on three esophageal adenocarcinoma cell lines (OE33, OE19 and FLO-1) by mul

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Li, L., S. Yuan, J. Sun, et al. "Genomic Profiling Identified Prognostic Biomarkers of Definitive Chemo-Radiotherapy Response in Esophageal Carcinoma." International Journal of Radiation Oncology*Biology*Physics 111, no. 3 (2021): S13. http://dx.doi.org/10.1016/j.ijrobp.2021.07.061.

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Dahlgaard, Jesper O., Karen Dybkaer, Hans Erik Johnsen, and Steen Knudsen. "A Novel Chemo Sensitivity Index for Melphalan Based on Gene Expression Profiling (GEP)." Blood 110, no. 11 (2007): 4191. http://dx.doi.org/10.1182/blood.v110.11.4191.4191.

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Abstract Multiple Myeloma (MM) is a lethal hematological malignancy with an incidence of 40–60 per 1.000.000 per year. Over the last decade, the most significant therapeutic improvement has been the introduction of high-dose Melphalan therapy in combination with autologous stem cell support. This strategy has led to an increase in survival from a median of approximately 3 years till now >6 years also in Denmark (unpublished data from Nordic Myeloma Study Group, NMSG #7/98). Despite this important increase in survival, substantial variability still persists among patients in response to high

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Pandotra, Pankaj, Bhavana Viz, Gandhi Ram, Ajai Prakash Gupta, and Suphla Gupta. "Multi-elemental profiling and chemo-metric validation revealed nutritional qualities of Zingiber officinale." Ecotoxicology and Environmental Safety 114 (April 2015): 222–31. http://dx.doi.org/10.1016/j.ecoenv.2014.01.021.

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Das, Arundhati, Kailash Chandra Samal, and Akshaya Kumar Bastia. "Chemo-profiling and assessment of antioxidant activity and antibacterial potentials of selected plants of family Combretaceae." GSC Biological and Pharmaceutical Sciences 10, no. 2 (2020): 030–39. https://doi.org/10.5281/zenodo.4280486.

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Traditional medicine is used all over the world, especially in developing countries. Though synthetic drugs are very effective but are harmful to human beings because of their side effects. Genus of <em>Terminalia</em> and <em>Combretum</em> species belongs to the family Combretaceae, which contains 20 genera and 600 species as herbs, shrubs, and trees. These plants are used in different traditional medicine for their antioxidant property and also for the treatment of hepatitis and malaria due to the presence of antibacterial properties. The present study is focused on

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Qiu, Tian, Samuel Maiwald, Brendan G. Dwyer, et al. "Abstract LB195: Activity based protein profiling on kinase PROTACs leads to the discovery of selective APT1/2 degrader." Cancer Research 85, no. 8_Supplement_2 (2025): LB195. https://doi.org/10.1158/1538-7445.am2025-lb195.

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Abstract Targeted protein degradation (TPD) refers to the use of small molecules to induce ubiquitin-dependent protein degradation. Most success has been achieved by designing selective degraders starting from known binders of a protein of interest (POI). Chemo-proteomics analysis of these degraders can be used to confirm their selectivity for target proteins but often results in the serendipitous discovery of additional degradation targets. While this has provided a means to the discovery of unanticipated degraders, the relatively low throughput of proteomics combined with the idiosyncrasy of

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Klempner, Samuel J., Julia Quintanilha, Ali Aboosaiedi, et al. "De-risking 1st line chemotherapy-free immune checkpoint inhibitor (ICI) use for patients with advanced gastroesophageal cancer (aGEJ) with tumor mutational burden (TMB)." Journal of Clinical Oncology 42, no. 3_suppl (2024): 407. http://dx.doi.org/10.1200/jco.2024.42.3_suppl.407.

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407 Background: ICI + chemotherapy (chemo-ICI) is becoming an increasingly common 1st line regimen for patients with aGEJ. However, direct outcome comparison between biomarker-enriched groups receiving chemo-ICI vs. ICI monotherapy (mono-ICI) is limited in phase III trials. We sought to evaluate if TMB might identify patients for whom mono-ICI vs. chemo-ICI might be de-risked. We prospectively hypothesized that (1) patients with TMB <10 mut/mB would have more favorable outcomes receiving ICI-chemo vs. mono-ICI and (2) patients with TMB ≥10 mut/mB would have diminished additional benefit fro

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Sankar, Anushya, Shanthi Periyasamy, and Sownthariya Chandrabalan. "In vitro Evaluation of Antioxidant Property, Chemo-profiling, Elemental Analysis of Morinda umbellata L." International Journal of Pharmaceutical Investigation 12, no. 4 (2022): 423–29. http://dx.doi.org/10.5530/ijpi.2022.4.73.

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Raiya, Birva, Shana Laliwala, Jayendra Patel, Pina Trivedi, and Hemangini Vora. "Routine Diagnostic Immunophenotypic Profiling in AML Identifies Chemo Resistant Patients and Predicts Treatment Outcomes." Asian Hematology Research Journal 7, no. 4 (2024): 160–69. https://doi.org/10.9734/ahrj/2024/v7i4180.

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De Felice, Marco, Pasquale Pisapia, Francesco Pepe, et al. "Unusual Clinical Experience in BRAF Exon 15 p.K601E-Mutated Lung Cancer: A Case Report and Brief Review of the Literature." Applied Sciences 12, no. 15 (2022): 7552. http://dx.doi.org/10.3390/app12157552.

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Molecular profiling has revolutionized the treatment of metastatic NSCLC. Uncommon mutations have been reported primarily in EGFR and BRAF genes and are frequently associated with atypical clinical presentations. Here, we present a rare case of a patient affected by BRAF exon 15 p.K601E-mutated lung cancer with synchronous peritoneal carcinomatosis. First line treatment with chemo-immunotherapy combinations provided a PFS of 8–9 months, whereas a second line treatment with BRAF and MEK inhibitors elicited a dissociated response. The latter clinical outcome suggests that these inhibitors have o

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Sudha, Thangirala, Kavitha Godugu, Gennadi V. Glinsky та Shaker A. Mousa. "Triazole Modified Tetraiodothyroacetic Acid Conjugated to Polyethylene Glycol, a Thyrointegrin αvβ3 Antagonist as a Radio- and Chemo-Sensitizer in Pancreatic Cancer". Biomedicines 10, № 4 (2022): 795. http://dx.doi.org/10.3390/biomedicines10040795.

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Thyroid hormone L thyroxine stimulates pancreatic carcinoma cell proliferation via thyrointegrin αvβ3 receptors, and antagonist tetraiodothyroacetic acid (tetrac) inhibits cancer cell growth. Chemically modified bis-triazole-tetrac conjugated with polyethylene glycol (P-bi-TAT) has higher binding affinity to αvβ3 receptors compared to tetrac. We investigated the antiproliferation effect of P-bi-TAT in pancreatic cancer cells (SUIT2) and its radio- and chemo-sensitizing roles in a mouse model of pancreatic cancer. P-bi-TAT treatment increased tumor-targeted radiation-induced cell death and decr

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Chen, Yang, Jiajia Yuan, Yanyan Li, et al. "Profiling heterogenous sizes of circulating tumor microemboli to track therapeutic resistance and prognosis in advanced gastric cancer." Human Cell 34, no. 5 (2021): 1446–54. http://dx.doi.org/10.1007/s13577-021-00568-2.

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AbstractCirculating tumor microemboli (CTM) aggregated by ≥ 2 circulating tumor cells (CTCs) are more migratory than single CTCs. Aside from the plasticity in their molecular characteristics, which have been considered tumor migration, CTM also possesses high size heterogeneity. This study, therefore, systematically investigated the heterogeneous sizes of CTM and their involvement in therapeutic resistance in 114 patients with advanced gastric cancer (GC) using a pre-established surface molecule-independent subtraction enrichment (SE)-iFISH strategy. CTM, which was pre-therapeutically detected

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Suresh Babu, Vishnu Suresh, Anadi Bisht, Ashwin Mallipatna, et al. "Enhanced Epithelial-to-Mesenchymal Transition and Chemoresistance in Advanced Retinoblastoma Tumors Is Driven by miR-181a." Cancers 14, no. 20 (2022): 5124. http://dx.doi.org/10.3390/cancers14205124.

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Advanced retinoblastoma (Rb) tumors display high metastatic spread to distant tissues, causing a potent threat to vision and life. Through transcriptomic profiling, we discovered key upregulated genes that belonged to the epithelial–mesenchymal transition (EMT) and chemotherapy resistance pathways in advanced Rb tumors. Through in vitro models, we further showed that Rb null tumor cells under prolonged chemo drug exposure, acquires a metastasis-like phenotype through the EMT program mediated by ZEB1 and SNAI2 and these cells further acquires chemotherapeutic resistance through cathepsin-L- and

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Hijazo-Pechero, Sara, Ania Alay, Raúl Marín, et al. "Gene Expression Profiling as a Potential Tool for Precision Oncology in Non-Small Cell Lung Cancer." Cancers 13, no. 19 (2021): 4734. http://dx.doi.org/10.3390/cancers13194734.

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Recent technological advances and the application of high-throughput mutation and transcriptome analyses have improved our understanding of cancer diseases, including non-small cell lung cancer. For instance, genomic profiling has allowed the identification of mutational events which can be treated with specific agents. However, detection of DNA alterations does not fully recapitulate the complexity of the disease and it does not allow selection of patients that benefit from chemo- or immunotherapy. In this context, transcriptional profiling has emerged as a promising tool for patient stratifi

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Zuccaro, Valentina, Andrea Lombardi, Erika Asperges, et al. "The Possible Role of Gut Microbiota and Microbial Translocation Profiling During Chemo-Free Treatment of Lymphoid Malignancies." International Journal of Molecular Sciences 20, no. 7 (2019): 1748. http://dx.doi.org/10.3390/ijms20071748.

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The crosstalk between gut microbiota (GM) and the immune system is intense and complex. When dysbiosis occurs, the resulting pro-inflammatory environment can lead to bacterial translocation, systemic immune activation, tissue damage, and cancerogenesis. GM composition seems to impact both the therapeutic activity and the side effects of anticancer treatment; in particular, robust evidence has shown that the GM modulates the response to immunotherapy in patients affected by metastatic melanoma. Despite accumulating knowledge supporting the role of GM composition in lymphomagenesis, unexplored a

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Bhandari, Koushik, Baishakhi De, Gargi Saha, and Tridib K. Goswami. "Black Tea: A Possible Multitherapeutic Combinatorics Aiding Neuroprotection in Alzheimer’s Disease." International Journal of Tea Science 14, no. 01 (2018): 62–66. http://dx.doi.org/10.20425/ijts1419.

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This article aims at reviewing the effectiveness of compounds in black tea in combating neuroinflammation in Alzheimer’s disease (AD). Detailed chemo profiling of black tea showed the presence of theaflavins, different catechins, and amino acids viz., L-theanine and methylxanthines. A literature search showed a multitude of pharmacological activities diversity of black tea. Structural and anti-inflammatory activity relationship studies showed the anti-inflammatory potentials of benzotropolone moiety containing compounds, flavonoids, flavones, phenolics and methylxanthines e.g. caffeine, theobr

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K, Brijesh, Nesari Tanuja, Mallya Suma V, and Kamath Madhusoodan. "Chemo-profiling of Pandanus odoratissimus L. fragrant inflorescence used in ayurveda, through HPTLC and GC." International Journal of Pharmacognosy and Life Science 1, no. 2 (2020): 18–23. http://dx.doi.org/10.33545/27072827.2020.v1.i2a.13.

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Righi, Davide, Laurence Marcourt, Alexey Koval, et al. "Chemo-Diversification of Plant Extracts Using a Generic Bromination Reaction and Monitoring by Metabolite Profiling." ACS Combinatorial Science 21, no. 3 (2019): 171–82. http://dx.doi.org/10.1021/acscombsci.8b00132.

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Kusari, Souvik, Selahaddin Sezgin, Katarina Nigutova, Eva Cellarova, and Michael Spiteller. "Spatial chemo-profiling of hypericin and related phytochemicals in Hypericum species using MALDI-HRMS imaging." Analytical and Bioanalytical Chemistry 407, no. 16 (2015): 4779–91. http://dx.doi.org/10.1007/s00216-015-8682-6.

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Cioce, Mario, Daniela Rutigliano, Annamaria Puglielli, and Vito Michele Fazio. "Butein-instigated miR-186-5p-dependent modulation of TWIST1 affects resistance to cisplatin and bioenergetics of Malignant Pleural Mesothelioma cells." Cancer Drug Resistance 5, no. 3 (2022): 814–28. http://dx.doi.org/10.20517/cdr.2022.56.

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Aim: Malignant pleural mesothelioma is a chemoresistant tumor, and biphasic and sarcomatoid histologies portend the worst prognosis for malignant pleural mesothelioma (MPM) patients. We obtained the microRNA expression profile of three biphasic-sarcomatoid MPM cell lines to identify commonly expressed microRNAs and evaluate the effect of butein, a chemo-sensitizing compound, on this microRNA subset. Methods: Nanostring-based microRNA profiling and analysis through the ROSALIND platform were employed to identify the commonly modulated microRNAs and their targets. MicroRNA-mimic transfection, Lu

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Suryanarayana Birudukota, N. V., Raimo Franke, and Bernd Hofer. "An approach to “escape from flatland”: chemo-enzymatic synthesis and biological profiling of a library of bridged bicyclic compounds." Organic & Biomolecular Chemistry 14, no. 15 (2016): 3821–37. http://dx.doi.org/10.1039/c5ob02539g.

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A small library of 78 bridged bicyclic compounds were synthesized via a chemo-enzymatic pathway. Biological evaluation suggested that rigid spherical scaffolds are useful to enhance the success rate of compound libraries for drug development.

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Patil, Neha, and Marian Girgis. "Outcome of germinal center B-cell type compared to non-germinal center/activated B-cell type diffuse large b-cell lymphoma as determined by immunohistochemistry using the Hans algorithm." Journal of Clinical Oncology 38, no. 15_suppl (2020): e20076-e20076. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.e20076.

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e20076 Background: Classification of diffuse large B cell lymphoma (DLBCL) takes into consideration - cell of origin, germinal center B-cell (GCB) vs non germinal center/activated B-cell type (non-GCB/ABC), since its determination by gene expression profiling predicts prognosis when treated with standard therapy. In this report we evaluated impact of choice of therapy and stem cell transplant (SCT) on the outcome of GBC and ABC subtype determined by immunohistochemistry (IHC) using Hans algorithm. Methods: We reviewed pathology reports DLBCL patients diagnosed from 2009 - 2016. For GCB and non

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Hong, Lingzhi, Muhammad Aminu, Xuetao Lu, et al. "Abstract 964: Genomic and clinical predictors of early disease progression and chemoimmunotherapy benefit in advanced NSCLC." Cancer Research 83, no. 7_Supplement (2023): 964. http://dx.doi.org/10.1158/1538-7445.am2023-964.

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Abstract Background: Immune checkpoint inhibitors (ICIs) as monotherapy (ICI-mono) or with chemotherapy (ICI-chemo) are standard first-line treatment in NSCLC patients lacking targetable driver mutations. Biomarkers to identify patients at risk for early progression on ICI-mono or those who would maximally benefit from upfront ICI-chemo have not been defined. Methods: We queried the GEMINI database to identify metastatic NSCLC patients without targetable EGFR/ALK alterations who were treated with ICI-mono or ICI-chemo. Mutational profiling was performed on tissue or blood using targeted NGS. O

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Koedoot, Esmee, Timothy J. Sijsenaar, Lieke J. Ceton, et al. "Abstract 6396: Ex vivo 3D micro tumor testing to assess chemotherapy and immunotherapy responses for NSCLC patients." Cancer Research 84, no. 6_Supplement (2024): 6396. http://dx.doi.org/10.1158/1538-7445.am2024-6396.

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Abstract Background: Systemic treatment options for NSCLC patients consists of chemo-, targeted or immunotherapy. Although predictive biomarkers can guide treatment decisions, response prediction for chemo- and immunotherapy is still a challenge. Recent studies showed the potential of functional testing to assess patient sensitivity to drugs in various cancers, but NSCLC is lacking. This study reports the feasibility of ex vivo 3D micro lung tumor testing with native tumor microenvironment (TME) to enable treatment sensitivity profiling for all drug classes in parallel. Methods: Fresh NSCLC tu

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Bhatt, Nusrat Fayaz, Raghbir Chand Gupta, and Yogita Bansal. "Organ-based chemo-profiling of Echinops echinatus Roxb. using high-performance thin-layer chromatography (HPTLC) technique." JPC – Journal of Planar Chromatography – Modern TLC 34, no. 2 (2021): 173–81. http://dx.doi.org/10.1007/s00764-021-00101-z.

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Das Arundhati, Samal Kailash Chandra, and Bastia Akshaya Kumar. "Chemo-profiling and assessment of antioxidant activity and antibacterial potentials of selected plants of family Combretaceae." GSC Biological and Pharmaceutical Sciences 10, no. 2 (2020): 030–39. http://dx.doi.org/10.30574/gscbps.2020.10.2.0016.

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Veselkov, K. A., R. Mirnezami, N. Strittmatter, et al. "Chemo-informatic strategy for imaging mass spectrometry-based hyperspectral profiling of lipid signatures in colorectal cancer." Proceedings of the National Academy of Sciences 111, no. 3 (2014): 1216–21. http://dx.doi.org/10.1073/pnas.1310524111.

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Pishvaian, Michael J., Hongkun Wang, Aiwu Ruth He, et al. "A pilot study of molecularly tailored therapy for patients with metastatic pancreatic cancer (MPC)." Journal of Clinical Oncology 33, no. 3_suppl (2015): 329. http://dx.doi.org/10.1200/jco.2015.33.3_suppl.329.

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329 Background: We have entered an era where multiple chemotherapeutic (chemo) agents can be utilized in the treatment (Tx) of patients (pts) with MPC. However, there are no methods for selecting the optimal regimen for any individual pt, and pure empiricism has not proven to be an optimal strategy. Molecular profiling is now widely used, albeit without evidence-based studies linking molecular profiles to Tx choices. Methods: We initiated a pilot study to assess the feasibility of following a simple algorithm, basing Tx on 3 published predictive markers of response to chemo: RRM1 (for gemcitab

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Kimura, Alisa, Takahiro Tsujikawa, Junichi Mitsuda, et al. "Abstract 5172: Tumor-immune microenvironmental profiling during chemo- and targeted therapy for head and neck squamous cell carcinoma." Cancer Research 83, no. 7_Supplement (2023): 5172. http://dx.doi.org/10.1158/1538-7445.am2023-5172.

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Abstract Understanding longitudinal changes of tumor-immune microenvironment during chemo/targeted therapies contributes to the development of optimized combinations of immunotherapy with chemotherapy and targeted therapy for patients with head and neck squamous cell carcinoma (HNSCC). We previously reported a chromogenic sequential immunohistochemical (IHC) platform enabling quantitative and spatial assessment of 29+ biomarkers in a single tissue section (Tsujikawa T et al. Cell Reports 2017, Banik G et al. Methods Enzymology 2020). Using this platform, densities, phenotypes, and distribution

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Zhang, Lei, Likun Hou, Junqi Wu, et al. "Peripheral blood mononuclear cells (PBMCs), an ideal liquid biopsy approach to evaluate systematic immunity and predict response of neoadjuvant chemo-immunotherapy in resectable NSCLC." Journal of Clinical Oncology 40, no. 16_suppl (2022): e20618-e20618. http://dx.doi.org/10.1200/jco.2022.40.16_suppl.e20618.

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e20618 Background: Immune checkpoint inhibitors (ICIs) dramatically improved clinical outcomes of patients with resectable non-small cell lung cancer (NSCLC). However, ICIs are not the scenario of “One-size fits to all”. It is of great importance to explore biomarkers, especially via liquid biopsy-based approach, to predict or monitor treatment response. Besides comprehensive genomic profiling of primary tumor tissue, this study focused on gene expression profile of PBMCs at baseline as well as one week post 1st immunotherapy administration, and its association with major pathological response

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Zhang, Lei, Likun Hou, Junqi Wu, et al. "Peripheral blood mononuclear cells (PBMCs), an ideal liquid biopsy approach to evaluate systematic immunity and predict response of neoadjuvant chemo-immunotherapy in resectable NSCLC." Journal of Clinical Oncology 40, no. 16_suppl (2022): e20618-e20618. http://dx.doi.org/10.1200/jco.2022.40.16_suppl.e20618.

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e20618 Background: Immune checkpoint inhibitors (ICIs) dramatically improved clinical outcomes of patients with resectable non-small cell lung cancer (NSCLC). However, ICIs are not the scenario of “One-size fits to all”. It is of great importance to explore biomarkers, especially via liquid biopsy-based approach, to predict or monitor treatment response. Besides comprehensive genomic profiling of primary tumor tissue, this study focused on gene expression profile of PBMCs at baseline as well as one week post 1st immunotherapy administration, and its association with major pathological response

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Sahu, Bhamini, Laxmipreeya Behera, Amrita Priyadarshini, and Kailash Ch Samal. "Vitro plantlet regeneration from Tinospora cordifolia (Willd.) Miers - a highly valuable medicinal plant and its chemo-profiling." International Journal of Chemical Studies 8, no. 3 (2020): 1424–29. http://dx.doi.org/10.22271/chemi.2020.v8.i3s.9397.

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Sheoran, Neelam, Agisha Valiya Nadakkakath, Vibhuti Munjal, et al. "Genetic analysis of plant endophytic Pseudomonas putida BP25 and chemo-profiling of its antimicrobial volatile organic compounds." Microbiological Research 173 (April 2015): 66–78. http://dx.doi.org/10.1016/j.micres.2015.02.001.

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Urbini, M., M. Canale, M. Flospergher, et al. "2017P Comprehensive molecular profiling of small cell lung cancer patients treated with chemo-immunotherapy or chemotherapy alone." Annals of Oncology 34 (October 2023): S1072—S1073. http://dx.doi.org/10.1016/j.annonc.2023.09.1248.

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