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Dissertations / Theses on the topic 'Chemoterapie'

Author: Grafiati

Published: 4 June 2021

Last updated: 18 February 2022

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1

Rutkauskienė, Giedrė. "Vaikų meduloblastomos klinikinės eigos ypatumai, gydant radioterapija ir palaikomąja chemoterapija." Doctoral thesis, Lithuanian Academic Libraries Network (LABT), 2006. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2006~D_20060925_214203-42383.

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Aim of the study was to evaluate the influence of clinical characteristics to the prognosis of disease and effectiveness of postoperative radiotherapy and adjuvant chemotherapy using lomustine, cisplatinum and vincristin in the treatment of children with medulloblastoma. This study was performed 2000 – 2005 in the Kaunas University of Medicine Hospital, department of children diseases. The data of patients, treated with medulloblastoma in 1994 - 2003, were used in this study. During ten-years period in Lithuania the medulloblastoma was diagnosed for 32 children. Twenty-seven of them were inclu

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2

Markelis, Rytis. "Sergančiųjų skrandžio vėžiu adjuvantinio gydymo efektyvumas po radikalių operacijų." Doctoral thesis, Lithuanian Academic Libraries Network (LABT), 2009. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2009~D_20091207_081331-89597.

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Skrandžio vėžys yra ketvirta pagal dažnį ir antra pagal mirtingumą onkologinė liga pasaulyje. Sergančių šia liga 5 metų išgyvenamumas siekia tik 25 proc. Esant didelei ligos atkryčio rizikai dažniausiai skiriama adjuvantinė chemoterapija, nors daugumoje atsitiktinių imčių studijų statistiškai reikšmingo išgyvenamumo pagerėjimo nenustatyta. Dažniausia skrandžio vėžio gydymo nesėkmės priežastis yra lokoregioninis recidyvas (40-65 proc. ligonių, kuriems atliktos radikalios operacijos) ir pilvaplėvės metastazės. Siekiant sumažinti lokoregioninių recidyvų dažnį, pradėtas taikyti suderintas chemospi

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3

Liutkauskienė, Sigita. "P53 baltymo raiškos ir kitų veiksnių prognozinės vertės tyrimas, gydant krūties vėžį chemoterapija ir granuliocitų kolonijas stimuliuojančiais faktoriais." Doctoral thesis, Lithuanian Academic Libraries Network (LABT), 2010. http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2010~D_20101122_113300-78280.

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Disertaciniame darbe analizuojama ankstyvo ir metastazavusio krūties vėžio prognozė priklausomai nuo skirtos chemoterapijos dozės ir molekulinių žymenų. Tyrimas susidėjo iš trijų etapų. I tyrimo etape buvo atlikta molekulinių žymenų (p53 baltymo, HER2, estrogeno ir progesterono receptorių) prognozinės vertės analizė retrospektyviojo ankstyvo krūties vėžio tyrimo metu, kartu įvertinta sumažintos chemoterapijos dozės įtaka ligos išeitims. II tyrimo etape ištirtas naujo rGKSF filgrastimo saugumas ir veiksmingumas gydant chemoterapija metastazavusį krūties vėžį. III tyrimo etape atlikta molekulini

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4

Notaro, Anna. "Préparation, caractérisation et évaluation biologique de complexes polypyridyles de ruthenium(II) comme agents anticancéreux." Thesis, Paris Sciences et Lettres (ComUE), 2019. http://www.theses.fr/2019PSLEC025.

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Ce projet de thèse porte sur la synthèse, la caractérisation et l'évaluation biologique de nouveauxcomplexes polypyridyles de Ru (II) en tant qu'agents chimiothérapeutiques contre le cancer. Lachimiothérapie est l’une des principales stratégies anticancéreuses, ainsi, l’industriepharmaceutique et le monde universitaire sont très investis dans la recherche de tels agents. Lesmédicaments à base de platine, tels que le cisplatine, le carboplatine et l'oxaliplatine, sont desmédicaments à base de métaux, approuvés et utilisés en clinique contre le cancer. Cependant, cestraitements peuvent entraîner

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5

Jančiauskienė, Rasa. "Gaubtinės ir tiesiosios žarnos vėžio chemoterapijos veiksmingumo įvertinimas." Doctoral thesis, Lithuanian Academic Libraries Network (LABT), 2006. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2006~D_20060222_151117-67092.

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1. INTRODUCTION Colon and rectum cancers (CRC) accounted for about 1 million new cases in 2002 (9.4 % of the world total) with about 529,000 deaths and 2.8 million alive with CRC diagnosed within 5 years of diagnosis [Parkin DM et al, 2005]. Recent estimates indicate that in 2004 CRC among the most common incident form of cancer in the Europe was in the second position with more than 380,000 new cases (13.2% of total). CRC was also one of two most common causes of cancer deaths in Europe (203,700 per year) [Boyle P et al, 2005]. A favourable pattern in CRC mortality for both genders was obser

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6

Latkauskas, Tadas. "Sergančiųjų II–III stadijos tiesiosios žarnos vėžiu chirurginio gydymo rezultatų įvertinimas po priešoperacinio spindulinio ir chemospindulinio gydymo." Doctoral thesis, Lithuanian Academic Libraries Network (LABT), 2010. http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2010~D_20100708_095442-63061.

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Perspektyvinio atsitiktinių imčių tyrimo tikslas – palyginti II–III stadijos rezektabilaus tiesiosios žarnos vėžio chirurginio gydymo rezultatus po priešoperacinės smulkiafrakcijinės spindulinės terapijos ir chemoterapijos ar priešoperacinės stambiafrakcijinės spindulinės terapijos. Darbo uždaviniai: 1. Atlikti sisteminės literatūros apžvalgos metu gautų duomenų matematinę analizę, tikslu palyginti smulkiafrakcijinės spindulinės tarapijos su chemoterapija ir stambiafrakcijinės spindulinės terapijos poveikį ir galimus skirtumus. 2. Nustatyti ir palyginti radikalių operacijų dažnį chST ir tST

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7

Maliauskaitė, Donata. "Obelų veislių virusologinė būklė ir devirusavimas in vitro." Master's thesis, Lithuanian Academic Libraries Network (LABT), 2013. http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2013~D_20130621_111205-44411.

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Darbo objektas − ištirti LAAMC SDI genetinių išteklių sodo obelų veislių virusologinę būklę ir taikant chemoterapijos ir termoterapijos metodus devirusuoti 'Connel Red' obels veislės mikroūglius. Darbo metodai: taikant PGR metodą ištirtos 35 introdukuotos obelų veislės įtrauktos į Nacionalinį augalų veislių sąrašą (2011 m.). Taikant chemoterapijos ir termoterapijos in vitro metodus siekta devirusuoti 'Connel Red' obels veislės mikroūglius. Tyrimai vykdyti Sodininkystės ir daržininkystės instituto (LAAMC SDI) sodo augalų genetikos ir biotechnologijos laboratorijoje. Virusų tyrimui 'Connel Red

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8

Druktenienė, Jurgita. "Pacientų nuomonė apie chemoterapijos dienos stacionaro paslaugas." Master's thesis, Lithuanian Academic Libraries Network (LABT), 2005. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2005~D_20050609_121407-41422.

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Aim of the study. To estimate patients’ opinion of services at the chemotherapy day-care department Methods. A survey was carried out at the Kaunas Medical University Hospital Chemotherapy department November 2004. 207 patients participated in it (response rate – 77,5 %). Statistical analysis was carried out using SPSS 11.5 for Windows. Associations between the variables were tested by Chi squared (χ²) test. Patients’ satisfaction with the doctors and nurses work was analyzed by measuring means that were compared using the Student test (t). Significance level (p) less than 0.05 was considered

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9

Balevičienė, Regina. "Moterų, sergančių vėžiu, gyvenimo kokybės sąsajos su klinikine ligos forma, gydymo būdais ir šeimynine padėtimi." Master's thesis, Lithuanian Academic Libraries Network (LABT), 2009. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2008~D_20090114_155926-38679.

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Vėžys dažniausiai asocijuojamas su mirtimi. Vis dėlto, ankstyva diagnozė ir taikomi nauji efektyvūs ligos gydymo būdai leidžia vėžiu sergančiam ligoniui vis ilgiau išgyventi. Tačiau suvokiama, kad, siekiant kaip galima ilgiau išsaugoti vėžiu sergančio žmogaus gyvybę, svarbu ne tik išgyventų metų skaičius, bet ir šių metų kokybė. Šiame darbe buvo siekiama įvertinti vėžiu sergančių moterų gyvenimo kokybės ypatumus priklausomai nuo vėžio formos (krūties, ginekologinis, kitos formos), gydymo metodo (chemoterapija ir spinduliavimas, kiti metodai), moterų šeimyninės situacijos (netekėjusios, ištekė

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10

Silva, Viviane Palmeira da. "Análise do comportamento das células de linhagens de carcinoma espinocelular de boca em microambiente ácido." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2017. http://hdl.handle.net/10183/157508.

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Ampliar nosso conhecimento sobre a biologia do carcinoma espinocelular bucal é fundamental para o desenvolvimento de novas estratégias terapêuticas e para melhorar a sobrevida dos pacientes acometidos por essa patologia. Para tanto, compreender as contribuições do microambiente tumoral à carcinogênese é muito importante. Um característica importante a ser avaliada do microambiente tumoral é a acidificação do meio extracelular. Considerando que o pH ácido tumoral está relacionado à maior agressividade da lesão, o objetivo deste projeto é estudar os efeitos de um microambiente ácido na biologia

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11

Brasiūnienė, Birutė. "Kasos vėžio kombinuoto gydymo įtaka ligonių gyvenimo trukmei ir gyvenimo kokybei." Doctoral thesis, Lithuanian Academic Libraries Network (LABT), 2006. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2006~D_20060130_151509-67222.

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Treatment of pancreatic cancer is an important medical problem. Most pancreatic cancer patients are diagnosed with advanced disease and their prognosis is poor. In Lithuania there were 440 new cases in year 2004. More than fifty percent of patients are diagnosed with stage IV disease [Kurtinaitis J et al., 2005]. Median survival of patients diagnosed with pancreatic cancer, depending on a stage of a disease, spread of the tumor, treatment method, functional status of a patient is from 6 to 20 months. Five-year survival is only 0–5 percent [Bramhall S et al., 1998; Oya N, 2004]. Today, pancre

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12

Brazienė, Jolanta. "Medikų,dirbančių su onkologiniais ligoniais, darbo sąlygų ir nusiskundimų sveikata sasajos." Master's thesis, Lithuanian Academic Libraries Network (LABT), 2008. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2008~D_20080616_145420-35201.

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Darbo tikslas: Įvertinti medikų nusiskundimų savo sveikata sąsajas su darbo sąlygomis. Darbo uždaviniai: 1. Ištirti medikų savo sveikatos vertinimą. 2. Įvertinti darbuotojų nuomonę apie darbo aplinkos rizikos veiksnius KMUK filialo Onkologijos ligoninėje. 3. Ištirti darbo sąlygų sąsajas su medikų nusiskundimais savo sveikatos būkle. 4. Pateikti rekomendacijas medikų sveikatos saugai KMUK filialo Onkologijos ligoninėje. Tyrimo metodika. Buvo atliktas vienmomentis paplitimo tyrimas. Anoniminės anketinės apklausos pagalba 2008m. vasario mėn. buvo apklausti KMUK filialo Onkologijos ligoninės medic

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13

Alaveckienė, Inga. "Chemoterapijos įtaka pacientų, sergančių onkologinėmis ligomis, mitybos būklei ir gyvenimo kokybei." Master's thesis, Lithuanian Academic Libraries Network (LABT), 2013. http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2013~D_20130618_095437-22970.

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Sergamumas piktybiniais navikais didėja. Kasmet Lietuvoje diagnozuojama po daugiau nei 17 800 naujų vėžio atvejų. Onkologinių ligonių gydyme dažnai taikoma chemoterapija, gydymas citotoksiniais preparatais. Šis gydymas sukelia eilę toksinių reiškinių, kurie pablogina paciento būklę, mitybos statusą, gydymo efektyvumą. Darbe tiriama, kaip pasikeičia pacientų, sergančių ginekologinės ir abdominalinės lokalizacijos piktybiniais navikais ir gaunančius gydymą chemoterapija, mityba, fizinė, emocinė, socialinė būsenos, kaip jos psichologiškai reaguoja į chemoterapinį gydymą. Darbo tikslas - įvertint

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14

Oliveira, Vilma Ferreira de. "Resposta inflamatória em cadelas após exerese de neoplasia mamária maligna submetidas a quimioterapia e suplementadas ou não com imunoestimulante." Universidade Federal de Goiás, 2014. http://repositorio.bc.ufg.br/tede/handle/tede/4050.

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Submitted by Luciana Ferreira (lucgeral@gmail.com) on 2015-01-30T11:41:08Z No. of bitstreams: 2 license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5) Tese - Vilma Ferreira de Oliveira - 2014.pdf: 1400510 bytes, checksum: 4e1a043e0e504c7215955ca226053318 (MD5)<br>Approved for entry into archive by Luciana Ferreira (lucgeral@gmail.com) on 2015-01-30T14:40:06Z (GMT) No. of bitstreams: 2 license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5) Tese - Vilma Ferreira de Oliveira - 2014.pdf: 1400510 bytes, checksum: 4e1a043e0e504c7215955ca226053318 (MD5)<br>Made

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Paula, Daniela Trivelato da Silveira de. "Atividade de análogos de imidazolidinas e hexahidropirimidinas em espécies de Leishmania associadas à leishmaniose cutânea." Universidade Federal de Juiz de Fora, 2012. https://repositorio.ufjf.br/jspui/handle/ufjf/2016.

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Submitted by Renata Lopes (renatasil82@gmail.com) on 2016-07-08T14:59:50Z No. of bitstreams: 1 danielatrivelatodasilveiradepaula.pdf: 1200045 bytes, checksum: f8ebaf5127aea71d80cdf654a3635613 (MD5)<br>Approved for entry into archive by Adriana Oliveira (adriana.oliveira@ufjf.edu.br) on 2016-07-13T16:33:54Z (GMT) No. of bitstreams: 1 danielatrivelatodasilveiradepaula.pdf: 1200045 bytes, checksum: f8ebaf5127aea71d80cdf654a3635613 (MD5)<br>Made available in DSpace on 2016-07-13T16:33:55Z (GMT). No. of bitstreams: 1 danielatrivelatodasilveiradepaula.pdf: 1200045 bytes, checksum: f8ebaf5127aea7

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Cruz, Érika de Paula da. "Estudo clínico, bioquímico e histológico do efeito da terapia fotodinâmica na mucosite oral induzida por 5-Fluorouracil em hamsters." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/23/23140/tde-19092014-173126/.

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A mucosite oral (MO) é uma consequência debilitante do tratamento quimioterápico, que pode ser aliviada com o uso de fototerapias. A terapia fotodinâmica (Photodynamic Therapy - PDT), pode ser usada para o tratamento da MO, quando esta se encontra infectada por microrganismos. No entanto, não há estudos que demonstrem se a PDT, quando aplicada sobre lesões em mucosa oral, pode interferir na reparação tecidual. Assim, este trabalho tem o objetivo de induzir a MO, em hamsters, através da confecção de ranhuras em animais que receberam o quimioterápico 5-Fluorouracil (5-FU), e avaliar, através de

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17

Cholevová, Lenka. "Chemoterapie kolorektálního karcinomu." Master's thesis, 2006. http://www.nusl.cz/ntk/nusl-272166.

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18

Chmelová, Helena. "Použití imunomodulace pro potenciaci chemoterapie polymerními cytostatiky." Master's thesis, 2009. http://www.nusl.cz/ntk/nusl-279727.

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Cancer treatment with polymer-bound cytostatic drugs and its potentiation through immunomodulation Poly[N-2-(hydroxypropyl)-methacrylamide] (PHPMA) is a synthetic water soluble and biocompatible polymer which can be used as a carrier of a cytostatic drug and an antibody as a targeting moiety. The antibody ensures the site-specific delivery of the conjugate. Nevertheless, even polymeric conjugates without any tumor-specific targeting moiety are passively accumulated within solid tumors via so called Enhanced Permeability and Retention (EPR) effect, in case that their molecular wight is at least

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19

Paračková, Zuzana. "Vliv chemoterapie na expresi imunoregulačních genů v mikroprostředí nádorů." Master's thesis, 2013. http://www.nusl.cz/ntk/nusl-321103.

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Tumor microenvironment is an area, where the local immunosuppressive effects dominate and prevents the immune system to perform its physiological functions. The cells infiltrating the microenvironment have an important function among many cell types since they produce a large quantity of factors suppressing the immune response. In our work, we monitored the immune changes in the microenvironment during tumor growth and chemotherapy. For these purposes, we utilized the methods for analysis of the proportion and phenotype of the distinct populations of immunocytes and for analysis of the total l

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20

Křivánková, Jana. "Změny nutričního stavu během vysokodávkované chemoterapie u vybraných hematoonkologických onemocnění." Master's thesis, 2021. http://www.nusl.cz/ntk/nusl-451056.

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Hematooncological diseases are often accompanied by dietary restriction, especially in cytotoxic therapy. The main purpose of the work was to assess the effect of high-dose chemotherapy on the change of nutritional status in two groups of hematooncological patients. A total of 16 patients were enrolled. Changes of the body composition were evaluated using bioelectrical impedance analysis supplemented by monitoring of biochemical nutritional indicators. Observations showed that in both groups the majority lost weight. In the first group of eight patients with acute myeloid leukemia observed dur

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21

Voříšková, Jana. "Využití kometového testu pro stanovení poškození DNA v průběhu protinádorové chemoterapie." Master's thesis, 2011. http://www.nusl.cz/ntk/nusl-296377.

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We have monitored the DNA damage induced by tumor chemotherapy. The combination of platin derivate (cis-platine or carboplatin) and another chemotherapy agent (gemcitabin, paclitaxel or vinorelbin) was applied to patients with lung carcinoma. The whole chemotherapy includes 4 cycles. We have monitored the DNA damage in peripheral blood lymphocytes through the first and the third cycle of chemotherapy and 3 weeks after the last cycle of chemotherapy. For detection we have used comet assay which seems to be accurate and reliable method. Lymphocytes were isolated from whole blood through the medi

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Hubáčková, Miluše. "Vliv biotransformace a transportu na účinky chemoterapie a prognózu rakoviny prsu." Doctoral thesis, 2013. http://www.nusl.cz/ntk/nusl-328224.

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Influence of biotransformation and transport to the effects of chemotherapy and prognosis of breast cancer Abstract: Introduction: The aim of this study was to evaluate the influence of biotransformation enzymes and enzymes of multidrug resistance for the prognosis and effects of chemotherapy of breast cancer patients. The first part dealed with the genetic factors and the influence of genetic polymorphisms in selected biotransformation genes and in ABCB1 gene and their influence in the formation and prognosis of breast cancer. In the second part, the expression profiles of these genes were an

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Krus, Ivona. "Vliv biotransformace a transportu xenobiotik na incidenci rakoviny kolorekta a účinky chemoterapie." Doctoral thesis, 2013. http://www.nusl.cz/ntk/nusl-328216.

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Introduction: Colorectal cancer (CRC) is one of the most frequent malignancies and affects approximately 5% of worldwide population. More than 75% of CRC cases represent sporadic forms. Susceptibility to nonhereditary CRC is significantly influenced by polymorphisms and mutations in low-penetrance genes. Variations in biotransformation and DNA repair genes may result in acumulation of toxins and DNA damage in cells leading to the development of cancer. Furthermore, different gene expression profiles of membrane transporters affecting the accumulation of anticancer drugs in tumour cells, e.g. A

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Hlaváč, Viktor. "Studium úlohy genetických faktorů v prognóze a predikci účinků chemoterapie karcinomu prsu." Doctoral thesis, 2017. http://www.nusl.cz/ntk/nusl-371012.

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Breast carcinoma is the most common cancer among women in our country and worldwide. One of the obstacles to successful therapy is a multidrug resistance. It can be caused by different factors, such as overexpression of ABC transporters, or decreased expression of SLC transporters, deregulation of drug metabolizing enzymes, variability of the targets of anticancer drugs, failure of apoptosis or increased capacity of repair genes. The aim of this study was to search for associations of genes of drug transport and metabolism with the prognosis of patients or response to chemotherapy. From the vi

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Plšková, Martina. "Vliv chemoterapie na mikrofloru dutiny ústní a střevní mikrofloru u onkologických pacientů." Master's thesis, 2012. http://www.nusl.cz/ntk/nusl-309660.

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Author: Bc. Martina Plšková Title: The effect of chemotherapy on the microflora in the oral cavity and intestinal microflora in cancer patients Field of study: Specialist in laboratory methods Objective: The aim of this study is to assess and compare changes of side effects of chemotherapy on the microflora in the oral cavity and large intestine in patients with colorectal cancer and breast cancer and to evaluate bacterial colonization during cancer treatment. Methods: Microbiological diagnostic testing of culture of swabs from the mouth and rectum. Results: The investigators found that chemot

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Brynychová, Veronika. "Studium úlohy genetických faktorů v prognóze a predikci účinku chemoterapie u pacientek s karcinomem prsu." Doctoral thesis, 2017. http://www.nusl.cz/ntk/nusl-370891.

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Changes in the regulation of apoptosis and cell cycle are involved in tumor development, progression, and resistance to antitumor therapy. The aim of this work was to evaluate the importance of apoptotic caspases and regulators of cytokineses as possible prognostic and predictive markers in breast carcinoma patients. In addition to determining the transcript levels of selected genes in tumor and control tissues obtained from breast carcinoma patients, we have also focused on the importance of alternative splice variants of caspases and their potential genetially determined regulation. We analy

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Kudělková, Martina. "Možnosti využití antivirotik v procesu eliminace virů u česneku kuchyňského." Doctoral thesis, 2016. http://www.nusl.cz/ntk/nusl-425531.

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The dissertation is focused on the effect of three antivirals (acyclovir, rimanatadine or zidovudine) for their potencial use in the process of chemotherapy in the combination of meristem culture method as a possible method for Onion yellow stripe virus, Leek yellow stripe virus, Garlic common laten virus and Shallot latent virus eradication in in vitro conditions. Antivirals were always applied separately into cultivation media and two amounts of antivirals (25 or 50 mg.l-1) were used. The treatment time was two weeks. Meristem culture only was a control method. Murashige and Skood medium w

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Mecl, Jan. "Výsledky vysokodávkované chemoterapie s podporou periferních kmenových buněk u pacientůs mnohočetným myelomem: zkušenosti centra. Srovnání jednotlivých léčebných postupů." Master's thesis, 2008. http://www.nusl.cz/ntk/nusl-294003.

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The submitted thesis is based on comparison of therapeutical effectivity of two different methods using in multiple myeloma patients for therapy. The best therapy seems to be single or tandem autologous stem cell transplantation ASCT with stimulation and separation of periferal blood stem cells (PBSCs). The stimulation could be done by CFA (cyclofosfamid) or cytostatik combinaňtion, e.g. IVE (ifosfamide, vepeside, epirubicine) in combination with G - CSF (granulocyte - colony - stimulating factor). The question which is not answered is which one of those methods is more effective. And which on

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MRÁZKOVÁ, Ivana. "Virocidní účinnost ribavirinu a acyklických nukleosid fosfonátů na virus žluté mozaiky vodnice." Master's thesis, 2010. http://www.nusl.cz/ntk/nusl-53042.

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A new method was developed for testing antiviral compounds against plant viruses based on rapidly growing brassicas in vitro on liquid medium. While using ribavirin as a standard for comparison, phytotoxicity and ability of the acyclic nucleotide analogues(R)-PMPA, PMEA, PMEDAP, and (S)-HPMPC to eliminate ssRNA Turnip yellow mosaic virus (TYMV) were evaluated by this method. Double antibody sandwich ELISA was used for relative quantification of viral protein in plants. Ribavirin had the most powerful antiviral effect against TYMV. On the other hand, (R)-PMPA and PMEA had no antiviral effect an

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Skálová, Helena. "Studium biomarkerů karcinomu prsu po neoadjuvantní léčbě." Doctoral thesis, 2020. http://www.nusl.cz/ntk/nusl-410798.

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Chemotherapy is one of the basic therapeutic procedures of breast cancer (BC) which may precede and/or follow the surgical resection of a tumor as a part of neoadjuvant or adjuvant therapy. However, the selective pressure of chemotherapy on tumor cells may change their molecular and expression profile and thus also their chemosensitivity. The aim of our work was to document the expression changes of selected markers in BC after neoadjuvant chemotherapy, which may contribute to the understanding of the role of these proteins and genes in tumor response to chemotherapy and the development of che

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VOZÁBOVÁ, Tereza. "Virocidní účinnost ribavirinu a acyklických nukleosid fosfonátů na virus mozaiky ředkvičky." Master's thesis, 2010. http://www.nusl.cz/ntk/nusl-110167.

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Evaluation of the antiviral effectiveness of ribavirin and acyclic nucleotide phosphonates to radish mosaic virus. Virus inoculation of plants with RaMV and immunological assay of the virus by ELISA. Subsequent application of antiviral agents and monitoring relative content of the virus in plants. Subsequent processing of data in tables and graphs, and then statistical evaluation.

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Stein, Radim. "Ochrana personálu při cytoredukční chirurgii a hypertermické intraperitoneální chemoterapii." Master's thesis, 2018. http://www.nusl.cz/ntk/nusl-386821.

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The diploma thesis deals with the protection of personnel in cytoreductive surgery and hyperthermic intraperitoneal chemotherapy, focusing on non-medical healthcare workers - anesthetist nurses. The aim of the work was to analyze the knowledge of anesthesia nurses in the use of personal protective equipment, the specifics of selection for the given performance, the use of an electrocautery with integrated suction, the availability of decontamination aids In case of an accident of cytotoxic substances and if the staff is afraid of their own health. The data was obtained through a questionnaire.

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CIMBÁLNÍKOVÁ, Eva. "Transplantace kostní dřeně, její historický vývoj a současné trendy." Master's thesis, 2019. http://www.nusl.cz/ntk/nusl-395695.

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The transplantation of bone marrow - more generally said of hematopoietic cells - is in the present time one of the modern therapeutical methods used in cases of malfunction of haematogenesis inside of the bone. The ususal reason for going through with transplantation is leukemia, lymphomas, also anemia, congenital metabolic disorders, autoimmune disorders or some of the solid tumors. Thanks to the transplantation of hematopoietic cells, it is possible to highten the chance of restoration in more than 50 % of patients suffering from oncological disease. The submitted thesis is processed in th

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Koutová, Linda. "MikroRNA v patogenezi AML." Doctoral thesis, 2019. http://www.nusl.cz/ntk/nusl-405909.

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Acute myeloid leukemia (AML) is a very heterogeneous disease associated with cytogenetic aberrations and genetic mutations. Many of these changes have been revealed and their detection became usual part of the diagnostic process today. However, changes of expression profiles of small, noncoding RNAs, so called microRNAs (miRNAs), are less known and not used for diagnostics yet. These RNAs, 19-24 nucleotides long, take part in the regulation of expression of different genes through complementary base pairing to the 3'non- translated region (3'UTR) of the target messenger RNA (mRNA). They can in

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Dostálek, Lukáš. "Možnosti značení lymfatických uzlin v axile u pacientek s karcinomem prsu." Doctoral thesis, 2021. http://www.nusl.cz/ntk/nusl-446960.

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Introduction Axillary dissection has little diagnostic and therapeutic benefit in the node-positive breast cancer patients in whom axillary disease has been completely eradicated after neoadjuvant chemotherapy (ypN0). We sought to assess the efficacy of an algorithm used for the identification of the ypN0 patients consisting of intraoperative evaluation of sentinel and tattooed (initially positive) lymph nodes. Methods Included were T1 and T2 breast cancer patients with one to three positive axillary lymph nodes marked with carbon who were referred for neoadjuvant chemotherapy followed by a su

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Haruštiak, Tomáš. "Optimalizace předooperační a operační léčby karcinomu jícnu a ezfago-gatstrické junkce: využití PET/CT v diagnostice a hodnocení efektivity předoperační chemoterapie a technika konstrukce anastomozy jako faktor pooperačních komplikací po ezofagektomii." Doctoral thesis, 2017. http://www.nusl.cz/ntk/nusl-372353.

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Key words: adenocarcinoma of the esophagus and esophagogastric junction, neoadjuvant chemotherapy, PET/CT, histopathological response, technique of esophagogastric anastomosis, anastomotic leak, anastomotic stricture Previous studies have shown that preoperative chemotherapy of locally advanced AEG is beneficial only for patients with a good histopathological response, the so-called responders. The aim of the first part of the thesis was to prospectively verify whether positron emission tomography (PET/CT) could be used for early identification of histopathological non- responders, who could b

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Jaščevská, Nikola. "Vliv topoisomerasy II beta na citlivost nádorových buněk k protinádorové terapii." Master's thesis, 2021. http://www.nusl.cz/ntk/nusl-446116.

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Charles University Faculty of Pharmacy in Hradec Králové Department of Biochemical Sciences Candidate: Nikola Jaščevská Supervisor: PharmDr. Anna Jirkovská, Ph.D. Title of diploma thesis: The effects of topoisomerase II beta on the sensitivity of the cancer cells to the antineoplastics Topoisomerase II (TOP II) is a cellular enzyme responsible for solving topological problems of double-stranded DNA. Alpha and beta isoforms of TOP II are different gene products having similar catalytic activities. The expression of TOP IIα is cell-cycle dependent, peaking in G2/M phase, while TOP II isoform is

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Černý, Viktor. "Užití biodegradabilních polymerních konjugátů s vysokou molekulovou hmotností k účinnému/ doručení cytostatických léčiv do solidních nádorů." Master's thesis, 2015. http://www.nusl.cz/ntk/nusl-353801.

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Cancer remains one of the most pressing issues of contemporary science and medicine. Incidence of malignant diseases is rising worldwide and they represent a major problem for the society due to both economic and ethical issues they cause. Although the progress in cancer biology, therapy and immunology has led to the introduction of many novel therapeutic protocols, approaches and drugs with specificity defined on a molecular level into clinical practice, many malignancies retain their poor prognosis. Therefore, intense research into new ways to increase our therapeutic options is warranted. U

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Kunická, Tereza. "Genetické faktory rezistence vůči chemoterapii a klinické charakteristiky nádorů prsu." Master's thesis, 2011. http://www.nusl.cz/ntk/nusl-312722.

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Breast cancer is the most frequent malignancy in women population both in the Czech Republic and worldwide. Treatment of this disease involves surgical removal of the tumor, radiotherapy, chemotherapy and hormonal therapy. Recently, targeted biological treatment is also approached. Each patient reacts to the treatment individually and thus high variability in response is common. Multidrug resistance (MDR) presents one of the most important obstacles to successful chemotherapy. MDR is often associated with a decreased intracellular accumulation of anticancer drugs and an increased expression of

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Sivák, Ladislav. "Překonání rezistence nádorů k chemoterapii pomocí konjugátů na bázi HPMA kopolymerů." Doctoral thesis, 2019. http://www.nusl.cz/ntk/nusl-406083.

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Multidrug resistance (MDR) is a common cause of failure in chemotherapy for malignant diseases. Cancer cells develop MDR most often via the up-regulation of P- glycoprotein (P-gp) expression. P-gp is an efflux pump with broad specificity belonging to ATP-binding cassette (ABC) transporters which decreases the intracellular concentration of various drugs. We designed polymeric conjugates based on an N-(2-hydroxypropyl)methacrylamide (HPMA) bearing a cytostatic drug and/or P-gp inhibitor and tested their cytostatic/cytotoxic activity in vitro and their therapeutic efficacy in vivo in MDR tumors.

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Hornychová, Helena. "Morfologické změny a prediktivní faktory u karcinomu prsu léčeného neoadjuvantní chemoterapií." Doctoral thesis, 2008. http://www.nusl.cz/ntk/nusl-294922.

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Zemanová, Milada. "Vztah vybraných ukazatelů nutričního stavu a výsledků léčby chemoterapií a operací u karcinomů jícnu." Doctoral thesis, 2011. http://www.nusl.cz/ntk/nusl-311603.

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The impact was assessed of clinical and nutritional factors on prognosis of 107 oesophageal cancer patients treated with neoadjuvant chemoradiotherapy (CHRT) and surgery. Individualised nutritional support, according to grade of dysphagia was carried out in all the patients. Serum leptin, soluble leptin receptors (SLR), TNF, IGF and fatty acid (FA) profiles in plasma phosphatidylcholine (PC) were studied as well. Addition of paclitaxel to carboplatin and continual fluorouracil significantly increased toxicity without influencing efficacy of the treatment. Post-operative node negativity, grade

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Assis, Joana Isabel Gomes. "Pharmacogenomic profile of ovarian cancer patients submitted to taxane-based chemoterapy." Tese, 2019. https://hdl.handle.net/10216/123626.

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Assis, Joana Isabel Gomes. "Pharmacogenomic profile of ovarian cancer patients submitted to taxane-based chemoterapy." Doctoral thesis, 2019. https://hdl.handle.net/10216/123626.

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Zimovjanová, Martina. "Predikce chemosenzitivity na 5-fluorouracil a jeho deriváty u nemocných léčených chemoterapií pro kolorektální karcinom." Doctoral thesis, 2009. http://www.nusl.cz/ntk/nusl-278737.

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Aim: 5-Fluorouracil (5-FU) is the most commonly used anticancer drug for colorectal cancer (CRC). Initially, we aimed to compare expression of 5-FU metabolic enzymes genes: thymidylate synthase (TS), thymidin phosphorylase (TP) and dihydropyrimidine dehydrogenase (DPD) in colorectal cancer and normal colon mucosa. We have tried to prove the correlation of the mRNA levels in fresh frozen tissues and protein expression using immunohistochemistry in paraffin-embedded colorectal cancer and adjacent normal tissues. Finally, we aimed to clarify the prognostic and predictive value of the expression o

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Šímová, Michaela. "Detekce povrchového fenotypu a chemosenzitivity buněk nádorů močového měchýře in vitro." Master's thesis, 2021. http://www.nusl.cz/ntk/nusl-438307.

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Tumor malignancies are the second leading cause of death worldwide. One of the reasons for the failure of oncological treatment are the uniformly set clinical guidelines, which neglect the effect of high intertumoral heterogeneity. The in vitro chemosensitivity and resistance (CSRA) assays allow for the stratification of patients prior to therapy. Therefore, the CSRA are a long-considered method for personalization of components of chemotherapy regime. Nevertheless, none of them is being routinely used in clinical practice. Certain chemotherapeutics used for their cytotoxic and cytostatic effe

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Matoušková, Klára. "Vliv preventivního podávání rekombinantního erytropoetinu na redukci potřeby transfúzí erytrocytů a další parametry u pacientů s Hodgkinovým lymfomem léčených intenzivní chemoterapií." Master's thesis, 2006. http://www.nusl.cz/ntk/nusl-268943.

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Belada, David. "Stanovení transkriptu BCL-2/IgH u nemocných s folikulárním B-nehodgkinským lymfomem léčených chemoterapií event. v kombinaci s monoklonální protilátkou anti CD20 - rituximabem." Doctoral thesis, 2008. http://www.nusl.cz/ntk/nusl-293317.

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