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Dissertations / Theses on the topic 'Chemotherapy-Induced'

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Published: 4 June 2021
Last updated: 9 March 2023

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1

Mulholland, K. C. "Experimental chemotherapy-induced mucositis." Thesis, Queen's University Belfast, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.479433.

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2

Lindner, Oana. "Chemotherapy-induced cognitive changes." Thesis, University of Manchester, 2015. https://www.research.manchester.ac.uk/portal/en/theses/chemotherapyinduced-cognitive-changes(48ea95ea-4510-41b6-850e-72e733747c7c).html.

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The present thesis, entitled Chemotherapy-induced cognitive changes, is being submitted in the alternative format, by Oana Calina Lindner to The University of Manchester for the degree of Doctor of Philosophy in the Faculty of Medical and Human Sciences, School of Psychological Sciences. The thesis consists of five empirical studies, written in article formats and three connecting chapters. The General introduction in Chapter 1, places the thesis in the context of late effects research in cancer survivors. I describe the prevalence of physical and emotional late effects, before going into more
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3

AlEjielat, Rowan Fahad Ibrahim. "Pharmacogenomics of chemotherapy induced cognitive dysfunction." Diss., University of Iowa, 2013. https://ir.uiowa.edu/etd/1528.

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Cognitive decline is increasingly recognized as a side effect of chemotherapy. However, cognitive decline doesn't occur in all patients receiving chemotherapy, and there is variability in the cognitive domains affected (Ahles; JCO,Oct 20, 2012:3675-3686). Safety pharmacogenomics, i.e. using genetic variations to predict response/toxicity, offers an exciting approach to identify the subset of patients most likely to suffer from cognitive decline post chemotherapy. Consequently specific therapeutic interventions can be developed to target this group of patients, and/or alternate chemotherapeutic
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4

Thomas, M. "STAT1 : a modulator of chemotherapy induced apoptosis." Thesis, Queen's University Belfast, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.426906.

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5

Roca-Alonso, Laura. "MicroRNA implications in chemotherapy-induced cardiac toxicity." Thesis, Imperial College London, 2014. http://hdl.handle.net/10044/1/24960.

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The use of anthracyclines such as doxorubicin (DOX) has improved mortality and morbidity in cancer patients, yet associated risks of cardiomyopathy have limited their clinical application. DOX-associated cardiotoxicity typically progresses to heart failure (HF). The knowledge of the mechanisms underlying DOX-related cardiac dysfunction is currently limited, hampering the development of cardioprotective strategies. MicroRNAs (miRNAs) are gene expression regulators that play potent roles in both cardiovascular disease and cancer. We wished to investigate DOX-induced changes in cardiac miRNA expr
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6

Bossaer, John B. "Olanzapine for Chemotherapy-Induced Nausea and Vomiting." Digital Commons @ East Tennessee State University, 2016. https://dc.etsu.edu/etsu-works/2312.

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7

Koning, Barbara Anna Eleonora de. "Chemotherapy induced intestinal mucositis: from bench to bed." [S.l.] : Rotterdam : [The Author] ; Erasmus University [Host], 2008. http://hdl.handle.net/1765/10865.

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8

Opperman, Caleigh Margaret. "Toxic mitochondrial effects induced by "red devil" chemotherapy." Thesis, Stellenbosch : Stellenbosch University, 2015. http://hdl.handle.net/10019.1/96676.

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Thesis (MSc)--Stellenbosch University, 2015.<br>ENGLISH ABSTRACT: Introduction: Doxorubicin (DOX), infamously known as the “red devil,” is considered the most effective antineoplastic drug utilized in oncologic practice today. However, its clinical use is hampered due to cumulative, dose-dependent cardiotoxicity, which can lead to reduced quality of life, irreversible heart failure and death. The mechanisms involved in the pathogenesis of cardiotoxicity have not been fully elucidated, but have previously been demonstrated to involve oxidative stress, calcium dysregulation and mitochondria
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9

Jarrett, Brant Lee. "Chemotherapy Induced Deficits in Cognition and Affective Behavior." The Ohio State University, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=osu1385457601.

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10

Tran, Cuong Duy. "Intestinal zinc and metallothionein : role in chemotherapy-induced mucositis." Title page, contents and abstract only, 2001. http://web4.library.adelaide.edu.au/theses/09PH/09phc9736.pdf.

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11

Bowen, Joanne Marie. "Chemotherapy-induced intestinal mucositis the role of apoptosis regulators /." Click here to access, 2006. http://thesis.library.adelaide.edu.au/public/adt-SUA20060831.142913/index.html.

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Thesis (Ph.D.) -- University of Adelaide, School of Medicine, Discipline of Medicine, 2006.<br>Includes author's previously published papers. "March 2006" Bibliography: leaves 168-191. Also available in a print form.
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12

McCormick, Barry. "Antioxidant protection in mitochondria in chemotherapy-induced neuropathic pain." Thesis, University of Aberdeen, 2015. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=229728.

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Neuropathic pain is a common and dose-limiting adverse effect of several cancer chemotherapeutic agents including paclitaxel. Current treatments for chemotherapy-induced peripheral neuropathy (CIPN) are largely ineffective and the pain can persist long after the cessation of the chemotherapy regimen. Whilst the specific underlying mechanisms are not fully understood, oxidative stress and mitochondrial damage are thought to be involved in the development of CIPN. Antioxidants which protect mitochondria may inhibit oxidative stress and protect mitochondrial function more effectively than antioxi
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13

Timmins, Hannah. "Chemotherapy-Induced Peripheral Neuropathy: Assessment, Phenotypes and Risk Factors." Thesis, The University of Sydney, 2021. https://hdl.handle.net/2123/25385.

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This thesis examined treatment specific chemotherapy-induced peripheral neuropathy (CIPN) profiles and explored patient characteristics which may contribute to CIPN severity utilising multimodal CIPN assessment in taxane and oxaliplatin treated patients. Initially, bilateral neuropathy assessments including clinical examination, neurophysiology and patient questionnaires revealed discrepancies between the patient experience and objective CIPN following taxane treatment. Further electrophysiological assessments revealed features more typical of entrapment neuropathy present in >50% of taxane-
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14

High, Rachel. "Detection of Chemotherapy-Induced Apoptosis in Human Breast Cancer." Thesis, The University of Arizona, 2015. http://hdl.handle.net/10150/578931.

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Caspase-cleaved keratin 18 (K18) is used as a biomarker of apoptosis to measure chemotherapy-induced cell death. The M30-FITC antibody can be used as a method of detection for caspase-cleaved K18, giving it potential as a prognostic and predictive tool in cancer treatment. This study tests the M30-FITC antibody for use with the human breast cancer cell lines MCF7, SKBR3, and MDA-MB-231 in flow cytometry, with the goal of optimizing the M30-FITC assay for use in human whole blood. The assay was evaluated for use with two different apoptotic pathways: first induced by the chemotherapy docetaxel
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15

BONOMO, ROBERTA. "ASSESSMENT OF METABOLOMIC CHANGES IN CHEMOTHERAPY-INDUCED PERIPHERAL NEUROPATHY." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2023. https://hdl.handle.net/10281/403017.

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La neuropatia periferica indotta da chemioterapia (CIPN) rappresenta da tempo uno degli effetti collaterali neurologici più rilevanti delle terapie oncologiche. Tuttavia, nonostante i progressi dei regimi terapeutici oncologici, la comparsa di importanti eventi avversi influisce ancora sull’efficacia della terapia antineoplastica, portando alla riduzione o all’interruzione del trattamento. Il paclitaxel è un efficace agente antitumorale utilizzato nel trattamento di diversi tumori, sebbene il suo uso clinico sia spesso limitato dall’insorgenza della neuropatia periferica indotta da paclitaxel
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16

Gao, Jiang [Verfasser]. "A novel concept for hyperthermia induced local chemotherapy / Jiang Gao." Berlin : Freie Universität Berlin, 2011. http://d-nb.info/1026174856/34.

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17

Bingham, J. M. M. "Gut mucosal architecture and barrier function in chemotherapy induced mucositis." Thesis, Queen's University Belfast, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.411063.

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18

Huang, Kevin M. "Contribution of organic cation-type transporters to chemotherapy-induced toxicities." The Ohio State University, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=osu1606768331375801.

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19

Lucas, Antigone. "Chemotherapy-Induced Cognitive Impairments: Targeting Neuroimmune Processes as Potential Treatments." Thesis, The University of Sydney, 2018. http://hdl.handle.net/2123/20561.

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Chemotherapy has prolonged the survival rates of cancer patients. However, chemotherapy causes peripheral neuropathies and cognitive impairments. Isolating which chemotherapy agents are responsible for these behavioural changes is difficult. Patients are given regimens that contain several agents alongside hormone therapy and radiation. Animal models are useful to elucidate which class of agents have the most neurotoxic effect and can determine which neural mechanisms are vulnerable to chemotherapy. Animal models can also determine which pharmacological agents reduce neurotoxic side effects to
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20

Gustafson, Heather Lynn. "Role of Manganese Superoxide Dismutase in Chemotherapy-induced Oxidative Stress." Diss., The University of Arizona, 2011. http://hdl.handle.net/10150/203510.

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Existing treatments for mantle cell lymphoma (MCL) are non-curative, demonstrating a need for a refined treatment approach. Recent clinical trials have shown promising results with the use of mammalian target of rapamycin inhibitors. I hypothesize that the anti-tumor effect of mTOR inhibitors in mantle cell lymphoma is mediated by an increase in manganese superoxide dismutase (MnSOD) protein expression and accumulation of hydrogen peroxide (H₂O₂). Findings indicate that the rapamycin-induced cytostatic effect is characterized by increased levels of MnSOD and H₂O₂, and is necessary for the full
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21

MOSCHETTI, GIORGIA. "TARGETING PROKINETICIN SYSTEM TO COUNTERACT EXPERIMENTAL CHEMOTHERAPY-INDUCED PERIPHERAL NEUROPATHY." Doctoral thesis, Università degli Studi di Milano, 2019. http://hdl.handle.net/2434/690366.

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La neuropatia periferica indotta da chemioterapici (CIPN) rappresenta uno degli effetti collaterali dose-limitante di numerosi agenti antineoplastici comunemente utilizzati in clinica. Il trattamento della CIPN, con i comuni farmaci analgesici è spesso insoddisfacente, pertanto è necessario lo sviluppo di nuovi approcci terapeutici. La patofisiologia della CIPN è molto complessa e non è stata ancora completamente chiarita; è caratterizzata da meccanismi multipatogenici tra cui: danno mitocondriale, stress ossidativo, alterazioni di canali ionici e neuroinfiammazione (Boyette-Davis et al., 2015
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22

Taylor, Vicki Leanne. "Whey growth factor protection against chemotherapy drug-induced toxicity in vitro /." Title page, contents and abstract only, 1998. http://web4.library.adelaide.edu.au/theses/09PH/09PHT246.pdf.

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23

Wong, Chung-lim, and 黃仲廉. "The role of GEP on chemotherapy induced alterations in hepatocellular carcinoma." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hdl.handle.net/10722/197132.

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Hepatocellular carcinoma (HCC) is the fifth most common malignancy and the third leading cause of cancer related death worldwide. Chemo-therapy has been commonly used to treat unresectable HCC but with limited efficacy. Therefore, there is an urgent demand for the development of better therapeutic approaches. Granulin-epithelin precursor (GEP) is a novel growth factor with over-expression in more than 70% of HCCs and has been demonstrated as potential therapeutic target. The aims of this study are to examine the role of GEP in chemo-resistance and the therapeutic potential of GEP antibody ther
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24

McDermott, Ultan. "The role of Fas in chemotherapy-induced colorectal cancer cell death." Thesis, Queen's University Belfast, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.426703.

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25

Rogers, K. M. A. "Interferon-γ-mediated modulation of chemotherapy-induced breast cancer cell death." Thesis, Queen's University Belfast, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.432507.

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26

Williams, Evan, and Jacob Dale Stearley. "Physicochemical Properties of a ‘Magic Mouthwash’ for Chemotherapy Induced Oral Mucositis." The University of Arizona, 2011. http://hdl.handle.net/10150/623534.

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Class of 2011 Abstract<br>OBJECTIVES: To determine the solubility and stability of hydrocortisone in a ‘magic mouthwash; suspension. METHODS: A literature review was conducted to establish the most common ingredients in a ‘magic mouthwash’ suspension It was decided that the test suspension would consist of 75% commercially available diphenhydramine solution, 12.5% nystatin suspension (100,000 units/ml) , and 12.5% lidocaine solution (2% lidocaine). Powdered hydrocortisone was then added to the test suspensions at different concentrations and stored at 27C, 38C, and 48C. Aliquots were taken fro
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27

Teng, Christina Sian Hwa. "Chemotherapy-induced peripheral neuropathy: Novel approaches to assessment, prevention and treatment." Thesis, The University of Sydney, 2022. https://hdl.handle.net/2123/29993.

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Chemotherapy-induced peripheral neuropathy (CIPN) is a common and often persistent problem of cancer treatment, with no proven preventative and few effective treatment strategies. Consensus is lacking about the appropriate tools to diagnose and monitor CIPN. With improved survival outcomes, it is increasingly important to understand the impact of CIPN and improve its management. The research in this thesis was conducted to characterise challenges that CIPN presents to patients and clinicians, and explore potential solutions. The thesis addresses the prevalence, assessment, and impact of CIP
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28

Seibert, Laurel, Sierra Vig, and Myke Green. "Impact of Olanzapine on Refractory Chemotherapy-Induced Nausea and Vomiting: a Retrospective Study." The University of Arizona, 2013. http://hdl.handle.net/10150/614310.

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Class of 2013 Abstract<br>Specific Aims: To describe the outcomes of olanzapine in the treatment of refractory chemotherapy-induced nausea and vomiting (CINV). Methods: Data were collected regarding demographic information, chemotherapy regimen, CINV prophylaxis, rescue antiemetics, and olanzapine usage for subjects, age 18-79, who were admitted to the University of Arizona Medical Center for chemotherapy and received at least one dose of olanzapine for CINV between January 2008 and January 2012. The primary outcome measure was the number of rescue antiemetics required following the first d
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29

Tofthagen, Cindy S. "Development and psychometric evaluation of the chemotherapy induced peripheral neuropathy assessment tool." [Tampa, Fla] : University of South Florida, 2008. http://purl.fcla.edu/usf/dc/et/SFE0002663.

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30

Ito, Katsuki, Kenji Hibi, Yasuhiro Kodera, and Seiji Akiyama. "Prolonged cytostatic tumor dormancy induced by serial exchange of chemotherapy in colorectal carcinoma." Nagoya University School of Medicine, 2004. http://hdl.handle.net/2237/5399.

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31

Al-Saffar, Nada M. Salman. "Investigations of Fas- and chemotherapy induced apoptosis in Jurkat T-cells using MRS." Thesis, Institute of Cancer Research (University Of London), 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.271613.

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32

Matthewman, Linda Alison. "Microbiota changes in acute chemotherapy-induced gastrointestinal injury and the efficacy of probiotics." Thesis, Royal Veterinary College (University of London), 2018. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.766326.

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33

Bloomingdale, Peter. "Machine Learning and Network-Based Systems Toxicology Modeling of Chemotherapy-Induced Peripheral Neuropathy." Thesis, State University of New York at Buffalo, 2019. http://pqdtopen.proquest.com/#viewpdf?dispub=13427432.

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<p> The overarching goal of my thesis work was to utilize the combination of mathematical and experimental models towards an effort to resolve chemotherapy-induced peripheral neuropathy (CIPN), one of the most common adverse effects of cancer chemotherapy. In chapter two, we have developed quantitative-structure toxicity relationship (QSTR) models using machine learning algorithms that enable the prediction of peripheral neuropathy incidence solely from a chemicals molecular structure. The QSTR models enable the prediction of clinical neurotoxicity, which could be potentially useful in early d
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34

Gardner, R., and John Bossaer. "Possible Drug-Induced Pancreatitis in a Patient Receiving Cyclophosphamide, Vincristine, and Prednisone Chemotherapy." Digital Commons @ East Tennessee State University, 2019. https://dc.etsu.edu/etsu-works/7797.

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Drug-induced pancreatitis is a condition characterized by sudden inflammation of the pancreas that can be mild or severe but usually subsides. Signs and symptoms consist of abdominal pain, nausea/vomiting, low-grade fever and pain radiating to the lower back. The incidence of acute drug-induced pancreatitis is approximately 2% but in patients that have disease states that predispose them to the development of pancreatitis, such as malignancy, hypercalcemia, tumor lysis syndrome, and immunosuppression it is found to be much higher. Conditions that should be considered in the differential diagno
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35

Vincent, Jacob Adam. "Sensorimotor Deficits Following Oxaliplatin Chemotherapy." Wright State University / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=wright1496136263522854.

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36

Wang, Jie. "Broad-Spectrum Protection Against Chemotherapy-Induced Alopecia by Acidic and Basic Fibroblast Growth Factors." The Ohio State University, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=osu1111433922.

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37

Gibson, Rachel J. "Chemotherapy-induced mucositis : mechanisms of damage, time course of events and possible preventative strategies /." Title page, table of contents and abstract only, 2004. http://web4.library.adelaide.edu.au/theses/09PH/09phg4481.pdf.

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38

Ramnarine, Sabrina. "Translational approach to the characterisation, early identification and treatment of chemotherapy-induced peripheral neuropathy." Thesis, University of Edinburgh, 2017. http://hdl.handle.net/1842/28888.

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Background Chemotherapy-induced peripheral neuropathy (CIPN) is a common dose-limiting toxicity with significant sequelae impacting prognosis and quality of life. The natural history and pathophysiological mechanisms of CIPN are unclear. Equally, the lack of systematic approach to diagnosis and assessments contribute to difficulty identifying at risk patients with implications on symptom burden. Effective management of CIPN is also difficult due to limited treatment options. To try and address this challenging clinical problem, this thesis aimed to adopt a translational approach to: 1) charact
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39

Lee, Jiyeon. "Exploring chemotherapy-induced nausea and vomiting: The symptoms, interventions, and relationship to functional status." Diss., Search in ProQuest Dissertations & Theses. UC Only, 2008. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3311334.

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40

Ritter, Andrea [Verfasser], and Andreas [Akademischer Betreuer] Bechthold. "Investigation of chemotherapy-induced non-coding RNA expression alterations in clinical breast cancer management." Freiburg : Universität, 2020. http://d-nb.info/1214179789/34.

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41

Hamada, Shota. "Antiemetic efficacy and safety of a combination of palonosetron, aprepitant, and dexamethasone in patients with testicular germ cell tumor receiving 5-day cisplatin-based combination chemotherapy." 京都大学 (Kyoto University), 2014. http://hdl.handle.net/2433/192148.

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Published in Supportive Care in Cancer 2014;22(8):2161-6. DOI:10.1007/s00520-014-2182-7<br>Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>博士(社会健康医学)<br>甲第18548号<br>社医博第59号<br>新制||社医||8(附属図書館)<br>31448<br>京都大学大学院医学研究科社会健康医学系専攻<br>(主査)教授 武藤 学, 教授 佐藤 俊哉, 教授 千葉 勉<br>学位規則第4条第1項該当
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42

McAllister, Rebecca Denise. "Evaluation of Oncology Nurses' Knowledge, Practice Behaviors, and Confidence Specific to Chemotherapy Induced Peripheral Neuropathy." Scholar Commons, 2010. http://scholarcommons.usf.edu/etd/3524.

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Chemotherapy induced peripheral neuropathy (CIPN) remains one of the most serious and challenging symptoms oncology nurses encounter in caring for patients receiving neurotoxic chemotherapy. CIPN is under-addressed, under-reported, and symptoms are minimized by healthcare providers, which adversely affect patient quality of life, physical function, and emotional well-being. There is an absence of research examining nurses’ knowledge and practice behaviors related to CIPN. The purpose of this study was to explore oncology nurses knowledge, practice behaviors, confidence, and the relationship be
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43

Seretny, Marta. "Investigating Chemotherapy Induced Peripheral Neuropathy (CIPN) and its treatment, using functional Magnetic Resonance Imaging (fMRI)." Thesis, University of Edinburgh, 2017. http://hdl.handle.net/1842/23611.

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Background: Chemotherapy Induced Peripheral Neuropathy (CIPN) is a debilitating neuropathy caused by commonly used chemotherapeutics. Clinically, the problem of CIPN is compounded by difficulties with diagnosis and limited treatment options. The pathophysiology of CIPN remains elusive, with current mechanistic postulates focused mainly on the peripheral nervous system. However, animal and human models of non-CIPN neuropathic conditions have shown the brain to be central to the development and maintenance of painful neuropathy. Moreover, evidence suggests that aberrant activity in key regions o
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44

Huang, Beijing Kara. "A quantitative analysis of chemotherapy-induced reactive oxidative species using genetically encoded sensors and generators." Thesis, Massachusetts Institute of Technology, 2015. http://hdl.handle.net/1721.1/103692.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Biological Engineering, 2015.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references.<br>Recent advances in chemotherapeutic development have targeted vital mechanisms that ensure survival of cancer cells; these include the ability to evade immune surveillance, undergo metabolic adaptations and form a defense mechanism against oxidative stress. Cancer cells often possess higher endogenous levels of reactive oxidative species (ROS) compared to normal cells due to the cumulative effects from genomic ins
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45

Piedra, Barrull Sheila 1992. "Targeting glial cells as a therapeutic approach for the treatment of chemotherapy-induced neuropathic pain." Doctoral thesis, TDX (Tesis Doctorals en Xarxa), 2022. http://hdl.handle.net/10803/673349.

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Chemotherapy-induced peripheral neuropathy (CIPN) is the most common adverse effect of many first-line antineoplastic agents, which negatively affects the quality of life and clinical outcome. Current clinical management of this condition provides unsatisfactory efficacy and unwanted side effects, highlighting the urgent need for the identification and development of novel effective therapeutic strategies that can prevent or mitigate this debilitating disease. Accumulating evidence has revealed that glial cells are powerful contributors to pathological pain of different etiologies; how
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46

Narayanaswamy, Hema Malini. "An exploratory study to investigate potential sensory biomarkers of chemotherapy-induced and diabetic peripheral neuropathy." Thesis, Imperial College London, 2012. http://hdl.handle.net/10044/1/9508.

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Aims: Identification of neurophysiological or skin innervation biomarkers which can be used to assess and monitor progression of diabetic sensory polyneuropathy (DPN) and chemotherapy-induced neuropathy (CIPN). Sensitive and robust measures are needed to detect changes in the relatively short duration of clinical trials aimed to modify progression of neuropathy. Methods: 40 patients with DPN were studied longitudinally over 1 year, and 33 patients with CIPN in a cross-sectional study. Clinical assessments, questionnaires, quantitative sensory testing, histamine-induced skin flare, nerve conduc
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47

Brisbois, Maryellen D. "Chemotherapy-Induced Premature Menopause Among Latina Women With Breast Cancer: An Interpretive Description: A Dissertation." eScholarship@UMMS, 2013. https://escholarship.umassmed.edu/gsn_diss/29.

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The description and interpretation of Latinas’ experience with chemotherapyinduced premature menopause from breast cancer treatment were explored in this study, which utilized an interpretive descriptive method from a feminist lens, and Knobf’s (1998, 2002) “Carrying on” theory. The specific aims of the study and the interview questions were guided by the state of the science literature. Overall, the impact of physiological effects, psychosocial effects, barriers, influencing factors that made their experience easier or harder, and how participants adjusted to a cancer diagnosis, treatment cou
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48

Sistigu, Antonella. "Inflammatory and immune reactions in response to chemotherapy-induced cell death. Viral mimicry chemotherapy : ds RNA sensors and IFNAR signalling indispensable for immunogenic tumor cell death." Thesis, Paris 11, 2013. http://www.theses.fr/2013PA11T052.

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Certains motifs moléculaires associés à la mort cellulaire semblent identifier les cancers prompts à répondre à une thérapie cytotoxique. Ceci en élaborant une réponse anti-tumorale basées sur une réponse T protectrice. Mon travail de thèse montre que le traitement par chimiothérapie immunogène active des voies moléculaires mimant une infection virale. Ceci conduit au niveau des cellules tumorales à une signalisation autocrine via l’IFNαβ / IFNAR1/2, initiée par la reconnaissance d’ARN double brin (dsRNA) endogène par les Récepteurs endosomaux de Reconnaissance des Motifs (PRRs). De façon plus
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49

Moradian, Saeed. "Management of chemotherapy-induced nausea and vomiting : a pilot randomised controlled trial using Nevasic audio programme." Thesis, University of Manchester, 2013. https://www.research.manchester.ac.uk/portal/en/theses/management-of-chemotherapyinduced-nausea-and-vomiting-a-pilot-randomised-controlled-trial-using-nevasic-audio-programme(29571f19-466c-4fdd-a9b9-725cc2634889).html.

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Major advances in antiemetic therapy have been made over the past two decades. Despite these advances in antiemetic management, nausea and vomiting are still important problems in clinical practice, and approximately 50% of patients receiving chemotherapy still experience nausea and/or vomiting, highlighting the need for further developments in the field. Non-pharmacological interventions are suggested as possible adjuncts to standard anti-emetic therapy. A recently developed non-pharmacological intervention to alleviate nausea and vomiting is Nevasic, which may have potential to reduce CINV a
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50

Poon, Sze-wan, and 潘詩尹. "An evidence-based guideline on using cryotherapy for chemotherapy-induced oral mucositis in adult cancer patients." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hub.hku.hk/bib/B48339192.

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Oral mucositis is a common adverse side-effect caused by cancer treatments and can lead to mucosa toxicity. Patients with oral mucositis may experience extreme pain and may not be able to eat, drink and talk and, as a result, their quality of life is impaired. Thirty to eighty five percent of patients undergoing chemotherapy would develop oral mucositis. Preventing or reducing incidence of oral mucositis and its severity can help reduce patients’ sufferings. One of the methods to achieve this objective is the oral cryotherapy, which is a prophylactic intervention. However, there is no evidenc
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