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Dissertations / Theses on the topic 'Chemotherapy of cancer'

Author: Grafiati
Published: 4 June 2021
Last updated: 14 February 2022

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1

Bates, Robert W. "Prodrugs for cancer chemotherapy." Thesis, University of Oxford, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.333294.

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2

Prytz, Anna, and Linda Harnfeldt. "Chemotherapy and Cancer - childrens experiences." Thesis, Kristianstad University College, Department of Health Sciences, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:hkr:diva-3754.

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<p>With good knowledge about the disease and the treatment, the fear and worry of children and parents can be reduced. Children may be helped by painting to express their experiences. In order to have a good care, the care-personnel need to see and understand what the children need. It is important to live an as regular life as possible during the disease and its treatment. The aim of this study was to elucidate how children experience chemotherapy in conection with their cancer disease. The method that was chosen was an systematic literature review. The result was based on five qualitative ar
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3

Sujendran, Vijay. "Neoadjuvant chemotherapy in oesophageal cancer." Thesis, University of East Anglia, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.501118.

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Neoadjuvant chemotherapy in oesophageal cancer has gained rapid favour in le United Kingdom over the past few years. It remains controversial outside the UK, with mixed results from clinical trials. The work in this thesis begins with a review of the literature on neoadjuvant chemotherapy, and of the antimetabolites and platinum agents used. The quantitative reverse transcriptase polymerase chain reaction (qRTPCR) used to identify molecular determinants of chemosensitivity is discussed followed by a look at the clinical experience of neoadjuvant chemotherapy at a single centre. Over the past s
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4

Miles, Philip James. "Metal complexes for cancer chemotherapy." Thesis, University of Manchester, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.627992.

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5

Taylor, W. B. "Control of emesis in cancer chemotherapy." Thesis, University of Newcastle upon Tyne, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.378877.

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6

Vacchelli, Erika. "Immunogenetic determinants of chemotherapy response in cancer." Thesis, Paris 11, 2014. http://www.theses.fr/2014PA11T041.

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L’efficacité de la chimiothérapie contre la croissance tumourale repose sur l'induction d'une mort des cellules tumourales dite immunogène. Les cellules tumourales mourantes agissent alors comme un vaccin thérapeutique en stimulant une réponse immunitaire anti-tumourale capable de contrôler, voire d'éliminer, les cellules cancéreuses résiduel. Les trois marqueurs principales de la mort cellulaire immunogène (MCI), sont (i) l'exposition pré-apoptotique de la calréticuline (CRT) à la surface des cellules, (ii) la sécrétion de l'ATP pendant l'apoptose qui dépend du processus d'autophagie, et (iii
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7

Jackson, Trachette L. "Mathematical models in two-step cancer chemotherapy /." Thesis, Connect to this title online; UW restricted, 1998. http://hdl.handle.net/1773/5730.

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8

Sims, Margaret Alison. "Azoreductases in cancer therapy." Thesis, Open University, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.261397.

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9

Smit, Egbert Frederik. "Aspects of palliative chemotherapy for lung cancer." [S.l. : [Groningen : s.n.] ; University Library Groningen] [Host], 1990. http://irs.ub.rug.nl/ppn/292220588.

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10

Kaestner, Sabine Anna. "Studies on dose-banding of cancer chemotherapy." Thesis, University of Bath, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.438893.

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11

Meerten, Esther van. "Chemotherapy and Chemoradiotherapy Studies in Oesophageal Cancer." [S.l.] : Rotterdam : [The Author] ; Erasmus University [Host], 2008. http://hdl.handle.net/1765/13209.

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12

Hartman, J. E. M. "Motor performance following chemotherapy for childhood cancer." [S.l.] : Rotterdam : [The Author] ; Erasmus University [Host], 2009. http://hdl.handle.net/1765/14636.

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13

Chen, Danny. "Approaches to improve efficacy of cancer chemotherapy /." The Ohio State University, 2002. http://rave.ohiolink.edu/etdc/view?acc_num=osu1486463321624467.

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14

Lindner, Oana. "Chemotherapy-induced cognitive changes." Thesis, University of Manchester, 2015. https://www.research.manchester.ac.uk/portal/en/theses/chemotherapyinduced-cognitive-changes(48ea95ea-4510-41b6-850e-72e733747c7c).html.

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The present thesis, entitled Chemotherapy-induced cognitive changes, is being submitted in the alternative format, by Oana Calina Lindner to The University of Manchester for the degree of Doctor of Philosophy in the Faculty of Medical and Human Sciences, School of Psychological Sciences. The thesis consists of five empirical studies, written in article formats and three connecting chapters. The General introduction in Chapter 1, places the thesis in the context of late effects research in cancer survivors. I describe the prevalence of physical and emotional late effects, before going into more
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15

Sutterfield, Shelbi Lorrae. "Microvascular function in patients undergoing chemotherapy." Thesis, Kansas State University, 2017. http://hdl.handle.net/2097/38216.

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Master of Science<br>Department of Kinesiology<br>Carl Ade<br>Adjuvant systemic chemotherapy for the treatment of certain cancers, particularly breast and lymphoma, adversely impacts cardiovascular health. However, the extent to which it impairs endothelial function is not well understood. Therefore, the purpose of this study was to determine if microvascular and macrovascular endothelial-dependent vasoreactivity is attenuated in breast cancer and lymphoma patients currently being treated with chemotherapy compared to healthy counterparts. With laser Doppler imaging, cutaneous microvascular fu
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16

Berglund, Åke. "Optimisation of Chemotherapy Treatment in Advanced Colorectal Cancer." Doctoral thesis, Uppsala University, Department of Oncology, Radiology and Clinical Immunology, 2002. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2609.

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<p>Colorectal cancer is one of the most common malignant diseases in Sweden – more than 5000 new cases are diagnosed each year. The overall five-year survival is about 60% and in cases of recurrence the prognosis is poor.</p><p>In a phase III study in advanced colorectal cancer the response rate was doubled when 5-FU was given as a bolus injection versus as a short infusion. The toxicity was similar and time to progression was longer in the injection group. However, overall survival was not significantly different. Dose-effect relationships of 5-FU were studied in another phase III study recru
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17

Tohnai, Iwai. "Chemotherapy using Intra-Arterial Infusion for Oral Cancer." Nagoya University School of Medicine, 2006. http://hdl.handle.net/2237/6962.

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18

Beyer, Kathryn. "Depression in patients with cancer receiving adjuvant chemotherapy." University of Southern Queensland, Faculty of Sciences, 2009. http://eprints.usq.edu.au/archive/00006177/.

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This simple quantitative research investigated whether patients with cancer developed depression whilst receiving adjuvant chemotherapy, and whether there was a particular time in the treatment cycle that it was likely to develop. A longitudinal survey method was chosen and the instrument of use was the Beck Depression Inventory II (BDI-II). The content of this survey include factors that reflect negative attitudes towards self, performance impairment and somatic disturbances as well as general factors of depression. Twenty-six participants were given the BDI-II, and asked to report on side ef
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19

Anderson, Judith Anne 1949. "Sleep and fatigue in cancer patients, receiving chemotherapy." Thesis, The University of Arizona, 1994. http://hdl.handle.net/10150/278425.

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A descriptive correlational study was conducted to examine the relationship between sleep characteristics and fatigue in persons with cancer, receiving chemotherapy. Twenty-five adult patients, receiving chemotherapy in outpatient and inpatient hospital settings, participated in the study. The Verran and Snyder-Halpern (VAS) Sleep Scale (1989) was used to measure the sleep characteristics of subjects and the Piper Fatigue Scale (PFS) (1992) was used to measure characteristics of fatigue. Demographic data were also collected. Significant relationships (p 0.05) were found between the dimension
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20

Bray, Johanne S. "Pharmacogenetic influences on the chemotherapy of breast cancer." Thesis, University of Newcastle Upon Tyne, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.506606.

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21

Rendle, P. M. "The preparation of possible prodrugs for cancer chemotherapy." Thesis, University of Canterbury. Chemistry, 1997. http://hdl.handle.net/10092/7259.

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This thesis concerns the design and preparation of compounds which are relevant to a new strategy for the selective chemotherapeutic treatment of tumour cells. These bridged polycyclic compounds are prepared by Diels-Alder chemistry involving cyclic dienes. The bridge is to be cleaved at the cancer site by tumour-selective chemistry acting on an appropriate trigger. This activation of a low toxicity 'prodrug' results in the formation of a planar, aromatic structure which is a characteristic of known anti-cancer drugs (intercalating agents). The crucial step in the organic synthesis of these p
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22

Newton, C. "Clinical resistance to platinum chemotherapy in ovarian cancer." Thesis, University College London (University of London), 2009. http://discovery.ucl.ac.uk/1446312/.

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Platinum drugs are the most active agents in ovarian cancer. Their cytotoxicty results from DNA crosslinking. High tumour response rates are seen, but 80 % of patients relapse. Major mechanisms of platinum resistance in patients remain to be established. We have studied DNA interstrand crosslinking and its repair in response to ex vivo treatment with cisplatin in forty patients with ovarian cancer using the single cell gel electrophoresis (comet) assay. Tumour cells from resected tumours or tumour and mesothelial cells from ascites were obtained from chemonaive patients and those relapsing aft
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23

Adlard, Julian Weldon. "Colorectal cancer : predictive factors for response to chemotherapy." Thesis, University of Leeds, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.415610.

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24

Dive, C. "Flow cytoenzymology with special reference to cancer chemotherapy." Thesis, Open University, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.384585.

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25

Zhao, Liang. "Evaluation of combination cancer chemotherapy theory and practice /." Connect to this title online, 2003. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1070398620.

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Thesis (Ph. D.)--Ohio State University, 2003.<br>Title from first page of PDF file. Document formatted into pages; contains xvii, 158 p.; also includes graphics (some col.) Includes bibliographical references (p. 146-158). Available online via OhioLINK's ETD Center
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26

Jansen, Catherine E. "Cognitive function in breast cancer patients undergoing chemotherapy." Diss., Search in ProQuest Dissertations & Theses. UC Only, 2007. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3261235.

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27

Zheng, Jenny Huimin. "Regional Cancer Chemotherapy: Drug Penetration and Pharmacokinetic Evaluation." The Ohio State University, 2000. http://rave.ohiolink.edu/etdc/view?acc_num=osu1392044351.

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28

Chen, Jun. "Transition Metal Complexes of Nucleosides for Cancer Chemotherapy." University of Dayton / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=dayton1461516224.

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29

Barnes, John George. "Synthesis of agents potentially useful in cancer chemotherapy." Thesis, University of Manchester, 2011. https://www.research.manchester.ac.uk/portal/en/theses/synthesis-of-agents-potentially-useful-in-cancer-chemotherapy(9ca50dd6-7c8f-4137-93a0-d68b77b596b6).html.

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A range of novel, potent, inhibitors of NAD(P)H quinone oxidoreductase 1 (NQO1) and NAD(P)H quinone oxidoreductase 2 (NQO2) were synthesised. The therapeutic utility of this could be three-fold: 1) Impairing tumour growth.2) Promoting the transient degradation of the p53 tumour suppressor protein in cells can enhance the activity of conventional anti-cancer drugs. 3) For probing the effects of NQO1 or NOQ2 inhibition within cells. The potential inhibitors were classified as three distinct groups based on the core structure, known as the triazoloacridinones (31), imidazoacridinones (131), and 4
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30

Kirkham, Amy Ashley. "Exercise cardio-protection from chemotherapy for breast cancer." Thesis, University of British Columbia, 2016. http://hdl.handle.net/2429/57056.

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One in nine women in Canada will be diagnosed with breast cancer during their lifetime, yet 88% will live for at least five years after diagnosis. Cardiovascular disease has become the most common cause of death of older breast cancer survivors, and breast cancer survivors are more likely to die of cardiovascular disease than women who have not had breast cancer. One of the contributing factors to the increased cardiovascular morbidity and mortality is anthracycline chemotherapy-related cardiotoxicity, or damage to the myocardium. The need for balance of oncological efficacy with cardiotoxicit
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31

Richardson, Alison. "Patterns of fatigue in patients receiving chemotherapy." Thesis, King's College London (University of London), 1995. https://kclpure.kcl.ac.uk/portal/en/theses/patterns-of-fatigue-in-patients-receiving-chemotherapy(077d4a6d-4c32-4639-93aa-f442e4d1775f).html.

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32

Zhang, Qian, and 张茜. "Retrospective analysis of bevacizumab and cetuximab in advanced Asian colorectal cancer patients." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2015. http://hdl.handle.net/10722/209506.

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Colorectal cancer is a serious health problem that has concerned people for decades. In Hong Kong, it is the most common cancer and the second leading cause of death. Among colorectal cancer patients, around 40-50% of them will develop metastatic disease. Chemotherapy is playing an important role all the time in the treatment of advanced colorectal cancer. In the past decade, the application of targeted therapies in treatment has largely improved efficacy and prolonged survival. Bevacizumab and cetuximab are two commonly used targeted agents in daily clinical practice of Hong Kong. Since multi
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33

Yan, Tristan Dongbo Clinical School St George Hospital Faculty of Medicine UNSW. "Cytoreductive surgery and perioperative intraperitoneal chemotherapy for peritoneal surface malignancy." Awarded by:University of New South Wales. Clinical School - St George Hospital, 2007. http://handle.unsw.edu.au/1959.4/40538.

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In the past, patients with peritoneal surface malignancy were considered incurable and were only offered palliative treatments. However, in a substantial number of patients, disease progression that is isolated to peritoneum may occur. It has been realised that elimination of peritoneal surface tumours may have an impact on the survival of these cancer patients, in whom a prominent cause of death is peritoneal carcinomatosis. The focus of this PhD. thesis is on the combined treatment of cytoreductive surgery and perioperative intrapersonal chemotherapy for diffuse malignant peritoneal mesothel
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34

High, Rachel. "Detection of Chemotherapy-Induced Apoptosis in Human Breast Cancer." Thesis, The University of Arizona, 2015. http://hdl.handle.net/10150/578931.

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Caspase-cleaved keratin 18 (K18) is used as a biomarker of apoptosis to measure chemotherapy-induced cell death. The M30-FITC antibody can be used as a method of detection for caspase-cleaved K18, giving it potential as a prognostic and predictive tool in cancer treatment. This study tests the M30-FITC antibody for use with the human breast cancer cell lines MCF7, SKBR3, and MDA-MB-231 in flow cytometry, with the goal of optimizing the M30-FITC assay for use in human whole blood. The assay was evaluated for use with two different apoptotic pathways: first induced by the chemotherapy docetaxel
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35

Berrieman, Helen Katherine. "Resistance to chemotherapy in non-small cell lung cancer." Thesis, University of Hull, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.415803.

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36

Evert, Jasmine. "Molecular studies of radiotherapy and chemotherapy in colorectal cancer." Doctoral thesis, Örebro universitet, Institutionen för hälsovetenskap och medicin, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-43635.

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37

Barnawi, Ibrahim. "Mechanisms of apoptosis resistance in chemotherapy-resistant cancer cells." Thesis, University of Reading, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.627931.

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Most chemotherapy drugs work through the induction of apoptosis in tumour cells. Mutations in apoptotic pathways, notably p53 and Bcl-2, are common in cancer and associated with increased resistance to apoptosis and therefore to chemotherapy. The sensitivity of two types of cells have been compared, A 172 human glioblastoma cells and MDA-MB-23l human breast cancer cells, for their sensitivity to the chemotherapy drugs cisplatin, doxorubicin, gemcitabine, vincristine and temozolomide. Data shows that there were differences in the sensitivity of breast cancer and glioma cells to a variety of che
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38

Khongkow, Pasarat. "The role of FOXM1 in breast cancer chemotherapy resistance." Thesis, Imperial College London, 2015. http://hdl.handle.net/10044/1/42884.

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Resistance to chemotherapeutic agents is the main obstacle to the effective breast cancer management. Therefore, it is important to elucidate the molecular mechanisms of chemoresistance and develop novel therapeutic strategies in order to overcome drug resistance. In this work, I found that FOXM1 is a critical mediator of epirubicin and paclitaxel resistance in MCF-7 breast cancer cell lines. FOXM1 expression was upregulated in both epirubicin resistant MCF-7 (MCF-7 EpiR) and paclitaxel resistant MCF-7 (MCF-7 TaxR) cells compared to sensitive MCF-7 cells. Interestingly, its depletion dramatica
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39

Weinberg, Brent D. "Intratumoral Chemotherapy for Liver Cancer Using Biodegradable Polymer Implants." Case Western Reserve University School of Graduate Studies / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=case1176749922.

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40

Shirai, Takako. "Primary chemotherapy patterns for ovarian cancer treatment in Japan." Kyoto University, 2010. http://hdl.handle.net/2433/120581.

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41

Garnier, Nicolas. "Mechanisms of action of the novel anti-cancer organic arsenical darinaparsin (ZIO-101, S-dimethylarsino- glutathione, Dar) in cancer cells." Thesis, McGill University, 2013. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=119553.

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Arsenic trioxide (ATO) is a successful treatment option for Acute Promyelocytic Leukemia (APL), but other cancers remain mildly sensitive to ATO at clinically achievable doses. Moreover, APL cells can develop resistance to ATO. It has been shown that resistance to ATO and/or moderate sensitivity correlates with either modulation of arsenic transport or increased expression of cytoprotective enzymes. Darinaparsin (S-dimethylarsino-GSH; Dar) is a significantly more potent apoptosis-inducing arsenical than ATO in various malignant cell lines and in APL patient blasts. It also has a maximum tolera
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42

Scherling, Carole Susan. "What Happens Before Chemotherapy?! Neuro-anatomical and -functional MRI Investigations of the Pre-chemotherapy Breast Cancer Brain." Thèse, Université d'Ottawa / University of Ottawa, 2011. http://hdl.handle.net/10393/20398.

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The side-effects of chemotherapy treatment are an increasingly important research focus as more cancer patients are reaching survivorship. While treatment allows for survival, it can also lead to problems which can significantly affect quality of life. Cognitive impairments after chemotherapy treatment are one such factor. First presented as anecdotal patient reports, over the last decade empirical evidence for this cognitive concern has been obtained. Much attention has been focused on post-chemotherapy research, yet little attention has been granted to these same patients’ cognition befor
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43

Petrovski, Andrei. "An application of genetic algorithms to chemotherapy treatment." Thesis, Robert Gordon University, 1998. http://hdl.handle.net/10059/1259.

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The present work investigates methods for optimising cancer chemotherapy within the bounds of clinical acceptability and making this optimisation easily accessible to oncologists. Clinical oncologists wish to be able to improve existing treatment regimens in a systematic, effective and reliable way. In order to satisfy these requirements a novel approach to chemotherapy optimisation has been developed, which utilises Genetic Algorithms in an intelligent search process for good chemotherapy treatments. The following chapters consequently address various issues related to this approach. Chapter
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44

MacPhee, Meaghan. "Stabilized combi-molecules for the treatment of breast cancer." Thesis, McGill University, 2009. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=40846.

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We recently developed a novel strategy termed “combi-targeting” that seeks to design “combi-molecules” which are able to not only block EGFR but to also damage DNA. Previous studies that sought to stabilize triazene based combi-molecules were based on masking the 1,2,3-triazene chain with a 2-acetoxymethylene group, leading to the synthesis of RB24 and RB107. The half-lives of these two molecules proved to be only about 5 minutes longer than their parent triazenes. The novel series of molecules presented herein were designed containing hydrolysable groups to modulate the kinetics of their degr
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45

Matheson, Karen Ann. "Learning needs of cancer patients receiving chemotherapy : patient, nurse, and physician perceptions." Thesis, University of British Columbia, 1987. http://hdl.handle.net/2429/26133.

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Accurate assessment of educational needs is central to the planning of effective patient education programs. Adult learning theory holds that the more agreement that exists in the educator's and the learner's assessment of learning needs, the higher the probability that effective learning will occur. This descriptive survey was carried out to compare the learning needs of cancer patients receiving chemotherapy as perceived by three groups involved in patient education: nurses, physicians, and patients themselves. Using the Assessment of Learning Needs Questionnaire (ALNQ) developed by Lauer,
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46

Hartmann, Neil Godfried. "Intercalative drugs in cancer chemotherapy : two approaches towards drug development." Thesis, University of Cambridge, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.292983.

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47

Petryk, Alicia Ailie. "Magnetic nanoparticle hyperthermia as an adjuvant cancer therapy with chemotherapy." Thesis, Dartmouth College, 2014. http://pqdtopen.proquest.com/#viewpdf?dispub=3634608.

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<p> Magnetic nanoparticle hyperthermia (mNPH) is an emerging cancer therapy which has shown to be most effective when applied in the adjuvant setting with chemotherapy, radiation or surgery. Although mNPH employs heat as a primary therapeutic modality, conventional heat may not be the only cytotoxic effect. As such, my studies have focused on the mechanism and use of mNPH alone and in conjunction with cisplatinum chemotherapy in murine breast cancer cells and a related in vivo model. MNPH was compared to conventional microwave tumor heating, with results suggesting that mNPH (mNP directly inje
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48

Burrow, Shuna M. "The membrane as a barrier or target in cancer chemotherapy." Thesis, University of Central Lancashire, 1997. http://clok.uclan.ac.uk/7909/.

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The overall aim of the project was to investigate the role of the cell membrane as a barrier and/or target for drug action and relate this to the development of strategies for overcoming multiple drug resistance (MDR). The effects of doxorubicin on various bacterial strains expressing different levels of anionic phospholipid were compared. Giowth of wild-type Echerichia coli (E. coli) strain MRE600 was severely affected up to 9 hours following doxorubicin treatment (15uM), but resistance occurred after 9 hours. E. coli strain FIDL1 1 was resistant to doxorubicin (1 O0piM) over 9 hours, however
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49

Beech, Adam. "Metabolic profiling analysis of pharmacodynamic responses to chemotherapy in cancer." Thesis, Imperial College London, 2016. http://hdl.handle.net/10044/1/51548.

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Cancer is one of the leading causes of death worldwide, and various chemotherapeutic agents are in use for its treatment. However, response to these therapies is generally low and resistance to these drugs is a daunting problem for cancer intervention. Prediction of response to drug treatment and the pharmacodynamics of response following treatment are important avenues for research into the clinical efficacy of chemical interventions in cancer, and in the goal of personalisation of medicine through patient stratification. This research project investigated potential pharmacodynamic biomarkers
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50

Robinson, Timothy. "Targeting cFLIP to inhibit residual cancer stem cells after chemotherapy." Thesis, Cardiff University, 2017. http://orca.cf.ac.uk/107539/.

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The emergence of the cancer stem cell (CSC) hypothesis has helped to explain previously poorly understood clinical concepts such as metastases, late tumour recurrence and resistance to chemotherapy. Triple Negative Breast Cancer (TNBC) has the worst prognosis of all types of breast cancer with a more frequent relapse rate and reduced length of survival in metastatic disease. It has been shown to contain a higher proportion of CSCs than other types of breast cancer. Paclitaxel, a taxane in widespread use in breast cancer, induces apoptosis in a ligand-independent manner through the extrinsic ap
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