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Dissertations / Theses on the topic 'Chemotherapy response'

Author: Grafiati

Published: 4 June 2021

Last updated: 27 July 2025

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1

Wong, Ka Yeung Mark. "Drug clearance mechanisms and chemotherapy response." Thesis, The University of Sydney, 2007. https://hdl.handle.net/2123/28094.

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Cytotoxic chemotherapeutic agents have a major role in the treatment of cancers. However, many cytotoxic agents have a narrow therapeutic window with best treatment response achieved only within a small range of drug concentrations.

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2

Vacchelli, Erika. "Immunogenetic determinants of chemotherapy response in cancer." Thesis, Paris 11, 2014. http://www.theses.fr/2014PA11T041.

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L’efficacité de la chimiothérapie contre la croissance tumourale repose sur l'induction d'une mort des cellules tumourales dite immunogène. Les cellules tumourales mourantes agissent alors comme un vaccin thérapeutique en stimulant une réponse immunitaire anti-tumourale capable de contrôler, voire d'éliminer, les cellules cancéreuses résiduel. Les trois marqueurs principales de la mort cellulaire immunogène (MCI), sont (i) l'exposition pré-apoptotique de la calréticuline (CRT) à la surface des cellules, (ii) la sécrétion de l'ATP pendant l'apoptose qui dépend du processus d'autophagie, et (iii

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3

Jaramillo, Melba Concepcion Corrales. "Redox Regulation of Chemotherapy Response in Lymphoma." Diss., The University of Arizona, 2010. http://hdl.handle.net/10150/193526.

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Glucocorticoids are exploited for the treatment of hematological malignancies due to their ability to cause apoptosis in lymphoid cells. Innate and acquired resistance, however, limits their efficacy in the clinic. The mechanisms contributing to resistance are poorly understood. A better understanding of the critical events during glucocorticoid-induced apoptosis are needed in order to develop novel agents that will exploit these critical targets and improve the response to glucocorticoid-based therapies. Previously, using WEHI7.2 murine thymic lymphoma cells, our laboratory demonstrated that

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4

Allen, W. L. "The role of Fas in response to chemotherapy." Thesis, Queen's University Belfast, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.403264.

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5

Adlard, Julian Weldon. "Colorectal cancer : predictive factors for response to chemotherapy." Thesis, University of Leeds, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.415610.

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6

Gao, Bo. "Genetic polymorphisms and chemotherapy response in ovarian cancer." Thesis, The University of Sydney, 2014. http://hdl.handle.net/2123/12884.

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Epithelial ovarian cancer (EOC) is usually treated with paclitaxel and carboplatin combination. Germline genetic variations may affect drug clearance therefore response. ABCB1 (ATP-binding cassette B1) is an efflux transporter of paclitaxel. We found an association between ABCB1 polymorphisms and survival in EOC patients. In lymphoblastoid cell lines (LCLs), ABCB1 expression correlated with transporter activity and paclitaxel sensitivity, but not with ABCB1 polymorphisms. In a prospective pharmacokinetic study, an association was identified between ABCB1 genotypes and paclitaxel clearance in t

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7

Wang, Kendric. "A systems biology approach for identifying markers of chemotherapy response." Thesis, University of British Columbia, 2012. http://hdl.handle.net/2429/42134.

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High-throughput gene expression data has been widely used to identify biomarkers for the classification of clinical outcome in cancer studies. In breast cancer, conventional methods have successfully identified molecular markers predictive of disease progression; however, predicting response to chemotherapy has proved more challenging and warrants the development of novel approaches. Recently developed systems biology methods that integrate transcriptomic and proteomic data have shown promising results in various classification problems; therefore, we investigated the use of this approach in p

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8

Narendrula, Rashmi. "rRNA Disruption: A Predictive Marker of Response to Taxane Chemotherapy." Thesis, Laurentian University of Sudbury, 2014. https://zone.biblio.laurentian.ca/dspace/handle/10219/2174.

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A recent clinical trial for locally advanced breast cancer patients treated with epirubicin and docetaxel prior to surgery reported significant dose-dependent reductions in tumour RNA integrity values which correlated with pathological complete response. The purpose of the present study was to assess whether similar chemotherapy-dependent alterations in RNA integrity could occur in vitro and to assess its relationship, if any, to apoptosis. Treatment of wildtype A2780 ovarian carcinoma cells with taxanes resulted in dose- and time-dependent RNA degradation, identified as several unique bands o

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9

Wen, Hao. "Albendazole chemotherapy and antibody response in cystic and alveolar echinococcosis." Thesis, University of Salford, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.262050.

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10

Pericleous, Stephanos. "Cholangiocarcinoma cell lines : proteomic analysis and enhancing response to chemotherapy." Thesis, Queen Mary, University of London, 2013. http://qmro.qmul.ac.uk/xmlui/handle/123456789/8622.

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Cholangiocarcinoma (CCA) is a rare cancer with a poor prognosis. Much of medical research has focused on investigating cancers with a higher incidence and little focus has been devoted to this disease. The aim of this thesis was to perform a protein analysis of CCA and cholangiocyte cell lines. Differences between immortalised cancer and normal cells were sought in order to identify potential therapeutic targets and/or diagnostic tools. A variety of CCA cell lines were used, reflecting both intra and extrahepatic disease. The different subtypes of CCA through the developed and developing world

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11

Jalgaonkar, Swati. "An investigation of Atf3, an adaptive-response gene, in breast cancer chemotherapy and stress response." The Ohio State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=osu1460387137.

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12

Ding, Zhenyu. "Molecular prediction of drug response using machine learning methods." Morgantown, W. Va. : [West Virginia University Libraries], 2008. https://eidr.wvu.edu/etd/documentdata.eTD?documentid=5544.

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Thesis (M.S.)--West Virginia University, 2008.<br>Title from document title page. Document formatted into pages; contains viii, 65 p. : ill. (some col.). Includes abstract. Includes bibliographical references (p. 63-65).

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13

Norris, Eleanor S. "Modelling the growth of avascular tumours and their response to chemotherapy." Thesis, University of Nottingham, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.246319.

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14

Freemantle, Sarah Joy. "Thymidylate synthase gene amplification and overexpression in response to antimetabolite chemotherapy." Thesis, University of Newcastle Upon Tyne, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.241530.

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15

Österberg, Lovisa. "Characterization of genetic alterations in ovarian cancer associated with chemotherapy response /." Göteborg : Department of Oncology, Institute of Clinical Sciences, The Sahlgrenska Academy at University of Gothenburg, 2009. http://hdl.handle.net/2077/20291.

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16

Marinovich, Michael Luke. "Imaging in measurement of response to neoadjuvant chemotherapy in breast cancer." Thesis, The University of Sydney, 2014. http://hdl.handle.net/2123/12462.

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Neoadjuvant chemotherapy (NAC) is chemotherapy delivered prior to breast cancer surgery, aimed at reducing tumour size and inducing pathologic complete response (pCR). The studies in this thesis evaluated the accuracy of imaging tests for assessing response during and after NAC. A systematic review of magnetic resonance imaging (MRI) during NAC to predict pCR (13 studies, N=605) found that accuracy was highest for alternatives to tumour size measurements (quantitative dynamic contrast and volumetric parameters). In a study of ultrasound for the same purpose (N=832), accuracy was higher than pr

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17

Nelmes, David-John. "Genetic biomarkers of chemotherapy response and resistance in lung cancer patients." Thesis, Cardiff University, 2018. http://orca.cf.ac.uk/109686/.

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In advanced lung cancer, careful selection of systemic anticancer therapy (SACT) is of vital importance. Companion biomarkers can optimise treatment selection, such as with the use of EGFR tyrosine kinase inhibitors (EGFR TKi) in patients with EGFRmut+ve adenocarcinoma of the lung. There is increasing interest in mutation detection and monitoring, in circulating cell free tumour DNA (ctDNA). This thesis reports that Next Generation Sequencing (NGS) with software VarScan with Annovar, can detect mutations at a 10-fold lower alternate allele frequency compared to alternative software available t

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18

Tran, William T. "Measuring chemotherapy response in breast cancer using optical and ultrasound spectroscopy." Thesis, Sheffield Hallam University, 2018. http://shura.shu.ac.uk/21926/.

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19

Brighenti, Elisa <1981&gt. "Relevance of cell cycle regulators on chemotherapy response in breast cancer." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2011. http://amsdottorato.unibo.it/3454/1/Brighenti_Elisa_tesi.pdf.

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20

Brighenti, Elisa <1981&gt. "Relevance of cell cycle regulators on chemotherapy response in breast cancer." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2011. http://amsdottorato.unibo.it/3454/.

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21

Aswad, Saad Ghazal. "The clinical and cellular pharmacology of carboplatin in relation to toxicity and response in epithelial ovarian cancer." Thesis, University of Newcastle Upon Tyne, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.241070.

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22

Ah-See, Mei-Lin Wong. "Evaluation of the vascular response to neoadjuvant chemotherapy in primary breast cancer." Thesis, University College London (University of London), 2007. http://discovery.ucl.ac.uk/1444532/.

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Neoadjuvant chemotherapy (NAC) is being increasingly used in the treatment of primary breast cancer (PBC). With the primary tumour in situ, the neoadjuvant treatment setting allows an in vivo assessment of tumour chemo-responsiveness and permits an evaluation of the possible underlying biological mechanisms of response. Angiogenesis is critical for the growth and metastases of breast cancer and with the development of novel agents targeting this process, an understanding of the vascular effects of conventional chemotherapy will enable the rational design of future drug combinations. Functional

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23

Coyle, V. "Identification of predictive markers of response to chemotherapy in advanced colorectal cancer." Thesis, Queen's University Belfast, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.517260.

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24

Canning, Paul. "Quantitative assessment of response to mitomycin C chemotherapy in superficial bladder cancer." Thesis, Queen's University Belfast, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.394633.

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25

McLean, Estelle Grace. "Pharmacogenomic identification of novel markers of response to chemotherapy in colorectal cancer." Thesis, Queen's University Belfast, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.437479.

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26

Huang, Rui. "Roles of HDACs in chromatin remodelling and response to chemotherapy in cancer." Thesis, University of Edinburgh, 2014. http://hdl.handle.net/1842/9626.

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Background: The higher-order structure of chromatin changes in response to extracellular and environmental signals. We observed nuclear morphological changes in biopsied cancer tissue after chemotherapy. Since chromatin structure dictates gene expression, and therefore function, further investigation of this phenomenon may increase our understanding of therapeutic responses. I hypothesised that nuclear morphological changes in cancer in response to DNA-damage by chemotherapy are mediated by histone deacetylases (de Ruijter, van Gennip et al.). Methods: Ovarian cancer cell lines PEO1/PEO4 (plat

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27

CAROCCIA, NATASCIA. "Antidepressants targeting the ubiquitin-proteasome-autophagy pathway increase mesothelioma response to chemotherapy." Doctoral thesis, Università degli studi di Ferrara, 2020. http://hdl.handle.net/11392/2488197.

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Malignant mesothelioma (MM) is a highly aggressive neoplasm with poor prognosis and survival averaging 6-12 months after diagnosis. The efficacy of the first-line treatment (pemetrexed plus cis-platinum) improves the overall survival of only 2-3 months because the marked resistance of MM cells to chemo-induced apoptosis limits response to the therapy. Recently, we demonstrated that the release of calcium (Ca2+) from the endoplasmic reticulum (ER) to mitochondria, a crucial event in apoptotic cell death, is deregulated in MM cells. Similarly, different studies highlighted a pivotal role of the

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28

Nakamura, Kenichi. "Determination of the optimal cutoff percentage of residual tumors to define the pathological response rate for gastric cancer treated with preoperative therapy (JCOG1004-A)." Kyoto University, 2016. http://hdl.handle.net/2433/217718.

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29

Saha, Arin Kumar. "On the prediction of response to neo-adjuvant chemotherapy for primary oesophageal adenocarcinoma." Thesis, University of Leeds, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.582135.

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Management of oesophageal cancer is associated with poor outcomes and it has become apparent that surgery alone is not sufficient to effect genuine long term survival. In the UK, it is standard practice to treat oesophageal adenocarcinoma with neo-adjuvant chemotherapy (no radiation) and surgery. One problem with this approach is the issue of those patients who do not respond. The aim of this study was to investigate biomarkers which might predict response to chemotherapy. Methods A retrospective audit was carried out on post-operative outcome after oesophagectomy from 2000 to 2006 and results

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30

Kennedy, R. D. "Investigation of the role played by BRCA1 in modulating the response to chemotherapy." Thesis, Queen's University Belfast, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.411374.

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31

McCulla, Andrea Anna Louise. "Pharmacogenomic identification and analysis of determinants of response to chemotherapy in colorectal cancer." Thesis, Queen's University Belfast, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.432662.

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32

Muhammad, Aun. "Microbubble ultrasound as surrogate imaging biomarker for response to systemic and regional chemotherapy." Thesis, Imperial College London, 2014. http://hdl.handle.net/10044/1/44958.

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New treatments such as anti-angiogenic therapy, chemoembolisation, radio-embolisation cause tumour stabilisation which may render conventional size based imaging invalid for monitoring early response to therapy. The aim of this thesis was to develop an alternative index which can predict response for patients with liver tumours earlier, at 2 weeks, than the contemporary gold standard response evaluation criteria at 3 months. This technique was based on the use of microbubble ultrasound as an alternative method for detection of hepatic arterialisation. In this thesis, I evaluated the microbubbl

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33

Harwood, Reuben. "The response of tumour-infiltrating myeloid cells to the chemotherapy-treatment of tumours." Thesis, University of Sheffield, 2013. http://etheses.whiterose.ac.uk/6640/.

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Myeloid cells are a major component of most forms of malignant tumour. The plasticity of such cells means that they can alter their phenotype in response to changes in the tumour microenvironment, including the pronounced ones that take place after chemotherapy. Tumour cell death, as well as the various cytokines and chemokines released by cells in tumours after such treatments, are now known to alter both the recruitment and function of myeloid cells. Recent studies have shown that monocytes recruited into tumours during/following chemotherapy can promote tumour chemoresistance and metastasis

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34

BENFANTE, Antonina. "BMP7v induces cancer stem cells differentiation and enhances chemotherapy response in colorectal cancer." Doctoral thesis, Università degli Studi di Palermo, 2014. http://hdl.handle.net/10447/91185.

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Cancer stem cells (CSCs), characterized by high levels of ATP-binding cassette, anti-apoptotic molecules, active DNA-repair and slow replication capacities, surviving to conventional anti-cancer therapies, able to eradicate only the highly proliferating tumor cells, represent the elective target for new therapies. Colorectal CSCs (CR-CSCs) represent a powerful tool for preclinical validation of target therapies. In particular the elucidation of the mechanisms that govern stem cell survival and differentiation appears very essential for the identification of new molecular targets in canc

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35

Fantozzi, Giulia. "Influence of centrosome amplification on the response to chemotherapy in epithelial ovarian cancer." Electronic Thesis or Diss., Université Paris sciences et lettres, 2023. http://www.theses.fr/2023UPSLS058.

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Le cancer épithélial de l’ovaire (CEO) est l’une des principales causes de décès par cancer chez la femme, en raison d’un diagnostic souvent tardif. Le traitement de première intention consiste en une chirurgie, suivie d’une combinaison de paclitaxel et de carboplatine comme chimiothérapie. Malgré une réponse initiale à ces traitements chez 80 % des patientes, malheureusement 70 % d’entre elles vont présenter une récidive. Le centrosome est le principal centre organisateur des microtubules dans les cellules animales. Il contribue à la division cellulaire, à la migration et à l’invasion. L’ampl

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36

Mirza, Ahmad. "Markers of treatment response for gastro-oesophageal cancers." Thesis, University of Manchester, 2012. https://www.research.manchester.ac.uk/portal/en/theses/markers-of-treatment-response-for-gastrooesophageal-cancers(c53c4845-7120-4490-831d-c27bfc823a93).html.

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Introduction: The incidence of gastro-oesophageal cancers has increased considerably over the last decade. As the disease is associated with a poor prognosis, there is a need to identify markers of treatment response which could be used in the future to improve the management of gastro-oesophageal tumours. Aims: 1) To compare the ability of published histological grading criteria (Becker, Mandard and Ninomiya) to assess response to neo-adjuvant chemotherapy (NCT) in gastro-oesophageal cancers. 2) To evaluate the expression of thymidylate synthase (TS) in pre-treatment diagnostic biopsy samples

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37

NAGANAWA, SHINJI, MASATAKA SAWAKI, AKIKO NISHIO, SATOKO ISHIGAKI, HIROKO SATAKE, and MARIKO KAWAMURA. "EARLY PREDICTION OF RESPONSE TO NEOADJUVANT CHEMOTHERAPY FOR LOCALLY ADVANCED BREAST CANCER USING MRI." Nagoya University School of Medicine, 2011. http://hdl.handle.net/2237/15357.

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38

Byström, Per. "Colorectal cancer treatment and early response evaluation how do we best evaluate treatment response? /." Stockholm, 2010. http://diss.kib.ki.se/2010/978-91-7409-766-5/.

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39

Scherling, Carole Susan. "What Happens Before Chemotherapy?! Neuro-anatomical and -functional MRI Investigations of the Pre-chemotherapy Breast Cancer Brain." Thèse, Université d'Ottawa / University of Ottawa, 2011. http://hdl.handle.net/10393/20398.

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The side-effects of chemotherapy treatment are an increasingly important research focus as more cancer patients are reaching survivorship. While treatment allows for survival, it can also lead to problems which can significantly affect quality of life. Cognitive impairments after chemotherapy treatment are one such factor. First presented as anecdotal patient reports, over the last decade empirical evidence for this cognitive concern has been obtained. Much attention has been focused on post-chemotherapy research, yet little attention has been granted to these same patients’ cognition befor

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40

Datta, Shreelata. "A study to investigate the immune response in ovarian cancer patients treated with chemotherapy." Thesis, Imperial College London, 2016. http://hdl.handle.net/10044/1/57030.

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Women with ovarian cancer usually present with advanced stage disease and, although sensitive to chemotherapy initially, the majority will relapse following first line treatment. Resistance to chemotherapy contributes to poor prognosis in ovarian cancer. A potential strategy to prolong the response to treatment and reduce chemotherapy resistance is immune based therapies. These therapies are likely to be most effective when disease is minimal or subclinical, such as at completion of first line chemotherapy, but depend on the ability to mobilize a sufficient immune response. Currently, little i

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41

Thaci, Louise Ann. "Flow cytometry for monitoring the response to chemotherapy in low grade B-cell disorders." Thesis, Ulster University, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.646857.

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Low Grade B-cell Disorders (LO-BCDs) have been found to be formed from B cells with clonal proliferations arising as B cells differentiate. There are 5 main groups of particular interest in this research project: Chronic Lymphocytic Leukaemia (CLL), Follicular Cell Lymphoma (FCL), Low Grade Lymphoma - unspecified (LOL) Mantle Cell Lymphoma (MCL) and Multiple Myeloma (MM). Currently, bone marrow analysis provides clear indication of relapse, though the procedure is invasive. Immunophenotyping of peripheral blood can identify minute numbers of T cells involved in the pathogenesis of relapse and

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42

Wilson, P. M. D. "A proteomic approach to identifying novel determinants of tumour response to chemotherapy in colorectal cancer." Thesis, Queen's University Belfast, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.487468.

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Colorectal cancer (CRC)is the leading cause of cancer-related deaths in the western world. In the metastatic setting, less than half of patients who undergo chemotherapy will receive any , ...' benefit from treatment. A major factor limiting the 'effectiveness of chemotherapy is .acquired or inherent drug-resistance. We have developed a panel of 5-fluorouracil- (5-FU-), oxaliplatinand CPT-ll-resistant HCT1l6 CRC cell lines and using 2D electrophoresis in combination with MALDI-TOF mass spectrometry, analysed differences in basal protein expression in parental and drug-resistant cells. Furtherm

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43

Ballal, H. "Investigation of association between natural variants in sub-cellular pathways and breast cancer chemotherapy response." Thesis, University of Liverpool, 2018. http://livrepository.liverpool.ac.uk/3015246/.

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Invasive breast cancer is the commonest cancer in the UK and adjuvant chemotherapy is often used to reduce the risk of local and distant recurrence in early stage disease. However, it is estimated that 70-80% of women receive no benefit from chemotherapy. In the current climate of personalised medicine the aim of the treating physician is to maximise individual benefit of treatment whilst minimising exposure to harmful side effects. Here we discuss the current tools available to stratify patients’ treatment including clinicopathological and molecular features, clinical guidelines, computer bas

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44

Braman, Nathaniel. "Novel Radiomics and Deep Learning Approaches Targeting the Tumor Environment to Predict Response to Chemotherapy." Case Western Reserve University School of Graduate Studies / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=case1586546527544791.

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45

Quartino, Angelica L. "Pharmacometric Models for Improved Prediction of Myelosuppression and Treatment Response in Oncology." Doctoral thesis, Uppsala universitet, Institutionen för farmaceutisk biovetenskap, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-150431.

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Chemotherapy plays an important role in the treatment of cancer. However, these drugs also cause death of non-malignant cells, resulting in severe side-effects. In addition, drug resistance may exist. Predictive tools for dose and drug selection are therefore warranted. In this thesis predictive pharmacometric models were developed for the main dose-limiting side-effect, neutropenia, and for treatment response following chemotherapy. Neutropenia is associated with a high risk for life-threatening infections and leads frequently to reduced dose delivery and thereby suboptimal treatment of the t

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46

Sistigu, Antonella. "Inflammatory and immune reactions in response to chemotherapy-induced cell death. Viral mimicry chemotherapy : ds RNA sensors and IFNAR signalling indispensable for immunogenic tumor cell death." Thesis, Paris 11, 2013. http://www.theses.fr/2013PA11T052.

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Certains motifs moléculaires associés à la mort cellulaire semblent identifier les cancers prompts à répondre à une thérapie cytotoxique. Ceci en élaborant une réponse anti-tumorale basées sur une réponse T protectrice. Mon travail de thèse montre que le traitement par chimiothérapie immunogène active des voies moléculaires mimant une infection virale. Ceci conduit au niveau des cellules tumorales à une signalisation autocrine via l’IFNαβ / IFNAR1/2, initiée par la reconnaissance d’ARN double brin (dsRNA) endogène par les Récepteurs endosomaux de Reconnaissance des Motifs (PRRs). De façon plus

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47

Yang, Ruizhen. "Cell-type and stimulus-dependent activation of p53 pathway in response to cytotoxic chemotherapeutics." HKBU Institutional Repository, 2019. https://repository.hkbu.edu.hk/etd_oa/646.

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Studies of drug resistance mostly characterize genetic mutations, and we know much less about the phenotypic mechanisms of drug resistance, especially at a quantitative level. p53 is an important mediator that regulates the cellular response to chemotherapy, but even cancer cells with wild-type p53 exhibited variable drug sensitivity for unclear reasons. In this PhD thesis, I investigated the mechanistic basis underlying differential p53 pathway activation in response to two types of chemotherapeutics, i.e., etoposide (a DNA-damaging drug) and 5-fluorouracil (5-FU, an antimetabolites), which l

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48

Aroori, S. "Identification of predictive markers of response to chemotherapy used in the treatment of human gastrointestinal cancers." Thesis, Queen's University Belfast, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.426969.

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49

Pickles, Martin Darren. "Prediction of response of patients with breast cancer to neoadjuvant chemotherapy using advanced magnetic resonance imaging." Thesis, University of Hull, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.440132.

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50

Suttie, Stuart Alistair. "The prediction of response to chemotherapy in patients with oesophago-gastric cencer using positron emission tomography." Thesis, University of Aberdeen, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.499960.

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Conventional anatomical imaging relies on changes in tumour volume, which do not become appreciable until late. Positron Emission Tomography (PET, using metabolically active tracers) offers an alternative, as metabolic changes occur prior to volume reduction. <sup>18</sup>FDG PET, monitoring glucose uptake in cells, has been used with some success. <sup>11</sup>C-Choline PET, monitoring cellular proliferation, may be more accurate. 18 patients with tumours at or around the gastro-oesophageal junction, underwent PET imaging with both <sup>18</sup>FDG and <sup>11</sup>C-Choline prior to and at d

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