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1

Back to normal: Why ordinary childhood behavior is mistaken for ADHD, bipolar disorder, and Autism Spectrum Disorder. Boston: Beacon Press, 2013.

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2

Anglada, Tracy. The childhood bipolar disorder answer book: Practical answers to the top 300 questions parents ask. Naperville, Ill: Sourcebooks, Inc., 2008.

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3

Janice, Papolos, ed. The bipolar child: The definitive and reassuring guide to childhood's most misunderstood disorder. New York: Broadway Books, 2002.

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4

Papolos, Demitri F. The bipolar child: The definitive and reassuring guide to childhood's most misunderstood disorder. New York: Broadway Books, 1999.

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5

Papolos, Demitri F. The bipolar child: The definitive and reassuring guide to childhood's most misunderstood disorder. 3rd ed. New York: Broadway Books, 2006.

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6

Papolos, Demitri F. The bipolar child: The definitive and reassuring guide to childhood's most misunderstood disorder. 3rd ed. New York: Broadway Books, 2006.

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7

Janice, Papolos, ed. The bipolar child: The definitive and reassuring guide to childhood's most misunderstood disorder. New York: Broadway Books, 1999.

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8

Childhood Bipolar Disorder Answer Book. Naperville: Sourcebooks, Inc., 2008.

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9

The Childhood Bipolar Disorder Answer Book. Sourcebooks, Inc., 2008.

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10

(Editor), Barbara Geller, and Melissa P. DelBello (Editor), eds. Bipolar Disorder in Childhood and Early Adolescence. The Guilford Press, 2005.

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11

(Editor), Barbara Geller, and Melissa P. Delbello (Editor), eds. Bipolar Disorder in Childhood and Early Adolescence. The Guilford Press, 2003.

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12

Back to Normal: Why Ordinary Childhood Behavior Is Mistaken for ADHD, Bipolar Disorder, and Autism Spectrum Disorder. Beacon Press, 2014.

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13

James, Anthony. Depressive Disorders in Childhood and Adolescence. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780198801900.003.0008.

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This chapter focuses on depressive disorders in childhood and adolescence. Depression in children and adolescents is a complex and debilitating disease, and typically has a lifelong, chronic, and recurrent course. The peak age of onset of depression is between 13 and 15 years. After providing a clinical picture of depression, this chapter discusses early childhood depression and differential diagnosis, including paediatric bipolar disorder, psychotic depression and seasonal affective disorder, oppositional and conduct disorder, and substance misuse and medical conditions. It then examines comorbidity, paying attention to bipolar disorder and suicidal behaviour, along with the assessment and prevention of depression. It also considers some of the determinants of depression, such as stress, trauma, life events, and biological factors such as genetics, brain mechanisms, hormones, and resilience. Finally, it describes treatment options for childhood and adolescent depression.
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14

Bipolar Children: Cutting-Edge Controversy, Insights, and Research (Childhood in America). Praeger Publishers, 2007.

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15

The COBAD Syndrome: New Hope for People Suffering from the Inherited Syndrome of Childhood-Onset Bipolar Disorder with ADHD. AuthorHouse, 2005.

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16

Slaughter, Carolyn. Masculinity and Disability. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780190458997.003.0016.

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Ernest Hemingway was plagued all his life by sexual arousal linked to associations developed in early childhood. In his letters and writing, Hemingway does not easily use “I” or “you.” From Paris, he writes to his boyhood friends as simply a male: “Bring a male up to date.” Psychoanalysts have given us a full range of Hemingway’s mental disabilities: latent homosexuality, posttraumatic stress disorder, bipolar disorder, narcissism, gender-identity issues, self-image issues, domestic abuse, alcoholism, and sexual inadequacy. His most profound disability might perhaps have been his disconnection from himself and others. His deepest longing was to dissolve with another in a way that did not require him to be a separate, individual person. Ultimately, Hemingway’s desire for dissolution led to self-murder, even as the chaos, rage, and agony of his bipolar mind brought with it an astonishing blessing: stark, intense, and magnificent prose.
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17

Levinson, Douglas F., and Walter E. Nichols. Genetics of Depression. Edited by Dennis S. Charney, Eric J. Nestler, Pamela Sklar, and Joseph D. Buxbaum. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190681425.003.0024.

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Major depressive disorder (MDD) is a common and heterogeneous complex trait. Twin heritability is 35%–40%, perhaps higher in severe/recurrent cases. Adverse life events (particularly during childhood) increase risk. Current evidence suggests some overlap in genetic factors among MDD, bipolar disorder, and schizophrenia. Large genome-wide association studies (GWAS) are now proving successful. Polygenic effects of common SNPs are substantial. Findings implicate genes with effects on synaptic development and function, including two obesity-associated genes (NEGR1 and OLFM4), but not previous “candidate genes.” It can now be expected that larger GWAS samples will produce additional associations that shed new light on MDD genetics.
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18

Post, Robert M. Depression as a Recurrent, Progressive Illness. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190603342.003.0003.

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Clinical Highlights and summary of Chapter• Episodes of depression and bipolar illness progress in two ways:faster recurrences as a function of number of prior episodes, andgreater autonomy (decreased need for precipitation by stressors(Episode Sensitization)• Recurrent stressors result in increased reactivity to subsequent stressors(Stress sensitization) and bouts of stimulant abuse increase in severity with repetition(Stimulant-induced behavioral sensitization)• Each type of sensitization cross-sensitizes to the others and drives illness progression• Each type of sensitization involves specific memory-like epigenetic processes as well as nonspecific cellular toxicities• Childhood onset depression and bipolar illness have a more adverse course than adult onset illness and are increasing in incidence via a cohort (year of birth) effect• As opposed to genetic vulnerability, each type of sensitization can be prevented with appropriate clinical intervention and prevention, which should lessen illness severity and progression• Seeing depression and bipolar disorder as progressive illnesses changes the therapeutic emphasis away from acute treatment and instead to long term prophylaxis• Preventing recurrent depressions will likely protect the brain, the body, and the personWord count with Named refs = 6,417>Depression and bipolar disorder are illnesses which tend to progress with each new recurrence. Stressors, mood episodes, and bouts of substance abuse each sensitize (show increased reactivity) upon their repetition and cross-sensitization to the others. These sensitization processes appear to have a memory-like and epigenetic basis, in some instances conveying lifelong increased vulnerability to illness recurrence and progression. Greater numbers of episodes are associated with faster recurrences, lesser need for stress precipitation, cognitive dysfunction, pathological changes in brain, treatment refractoriness, and loss of many years of life expectancy, predominantly from cardiovascular disease. Such a perspective emphasizes the need for greater awareness of higher incidence of psychiatric and medical comorbidities in the United States compared to many European countries, and the need for earlier intervention and more sustained long term prophylaxis to prevent illness progression and its adverse consequences on brain and body.
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19

Papolos, Janice, and Demitri Papolos MD. The Bipolar Child: The Definitive and Reassuring Guide to Childhood's Most Misunderstood Disorder. Tantor Audio, 2018.

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20

Papolos, Demitri, and Janice Papolos. The Bipolar Child: The Definitive and Reassuring Guide to Childhood's Most Misunderstood Disorder. Broadway, 2000.

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21

Papolos, Janice, and Demitri Papolos MD. The Bipolar Child: The Definitive and Reassuring Guide to Childhood's Most Misunderstood Disorder. Tantor Audio, 2018.

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22

The Bipolar Child: The Definitive and Reassuring Guide to Childhood's Most Misunderstood Disorder -- Third Edition. 3rd ed. Broadway, 2007.

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23

Papolos, Demitri Md, and Janice Papolos. The Bipolar Child: The Definitive and Reassuring Guide to Childhood's Most Misunderstood Disorder -- Third Edition. 3rd ed. Broadway, 2006.

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24

Papolos, Demitri Md, and Janice Papolos. The Bipolar Child: The Definitive and Reassuring Guide to Childhood's Most Misunderstood Disorder (Revised and Expanded Edition). Broadway, 2002.

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25

Mohammad, Shafii, and Shafii Sharon Lee, eds. Clinical guide to depression in children and adolescents. Washington, DC: American Psychiatric Press, 1992.

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