Academic literature on the topic 'Children's plays. [from old catalog]'

Purpose – The purposes of this paper are to investigate the effects of integrated advertising formats on the persuasion of children, children’s awareness of the persuasive intent of these formats and how this awareness mediates the level of persuasion. Design/methodology/approach – An one-factor between-subjects experiment was conducted among 117 boys from 8 to 12 years old. Findings – This study showed that boys were more aware of the persuasive intent of a non-integrated catalog than of a brand-integrated magazine. In addition, higher awareness of the persuasive intent of the catalog enhanced persuasion in boys. Research limitations/implications – This study only focused on boys’ responses and not on girls. Practical implications – Findings imply that advertisers could focus on non-integrated print advertising formats, such as catalogs, to promote positive product attitudes among boys. Catalogs are also a more ethical way of communicating to boys because boys are generally aware of catalogs’ persuasive intent. Social implications – This study implies that even if children have sufficient persuasion knowledge, they do not necessarily use it to critically evaluate advertising. Originality/value – This paper is the first to systematically test the differences in effects of brand-integrated magazines versus catalogs targeted toward children. Importantly, it shows that persuasion knowledge plays a fundamentally different role in the persuasion process of children than of adults: awareness of the persuasive intent of catalogs increases persuasion among boys, whereas previous studies among adults showed opposite results.

This study explores the role of paradigm uniformity bias in the acquisition of Korean verbal inflections. Paradigm uniformity bias has been proposed in a constraint-based phonological framework, but has rarely been supported by experimental data. This paper provides experimental evidence for paradigm uniformity bias from four- to seven-year-old Korean children learning their native language phonology. Experiment 1 demonstrates that children alter morphological structures in order to produce non-alternating verb forms. Experiment 2 shows that the tendency to adjust morphological structures is rooted in children's preference for uniform paradigms, not in their ignorance of alternations. The results suggest that paradigm uniformity bias plays a role in determining children's preferred production patterns, which favour non-alternating forms even after they have acquired adult-like knowledge of the patterns of alternations.

Aims: To quantify the impact of the South African old age (social) pension on outcomes for pensioners and the prime-aged adults and children who live with them, and to examine alternative means by which pensions affect household outcomes. Methods: We collected socioeconomic data on 290 households in the Agincourt demographic surveillance area (DSA), stratifying our sample on the presence of a household member age-eligible for the old-age pension (women aged 60 and older, men aged 65 and older). Results: The presence of a pensioner significantly reduces household reports that adults and, separately, children missed meals because there was not enough money for food. In addition, girls are significantly more likely to be enrolled in school if they are living with a pensioner, an effect that is driven entirely by living with a female pensioner. Our results are consistent with a model in which pensioners have a greater say in household functioning once they begin to receive their pensions. Conclusions: We find a program targeted toward the elderly plays a significant role in children's health and development.

Abstract Using data from the 1995 Malawi Financial Markets and Food Security Survey, this study seeks to discover if rural Malawian women's relative control over household resources or intra-household bargaining power, gauged by their access to microcredit, plays a role in young children's food security. Access to microcredit is assessed in a novel way as self-reported credit limits at microcredit organizations. Since credit limits, that is, the maximum sums that might be borrowed, hinge upon supply-side factors such as the availability of credit programs and the financial resources of lenders, it is plausible they are more exogenous than demand driven loan uptake or participation in microcredit organizations, the common ways of gauging access to microcredit. It is found that household expenditure on food significantly increases in women's, though not in men's, access to microcredit. Thus, increasing rural Malawian women's relative control over household resources may yield children greater food security. It is also found that women's access to microcredit improves 0–6 year old girls', though not boys', long-term nutrition. Thus, empowering these women may deliver more benefit to girls than boys.

MP-ASI plays a role important in support Child growth . If mom not quick introduce MPASI with the right way for children moment he enter 6 months old , growing the flower can just disturbed . Activity MP-ASI socialization to mothers for Improving the Nutritional Status of Children carried out on day Tuesday, November 22, 2022 at the Village Office Dewi Sri District sea tador . Destination beginning MPASI socialization is for give understanding to women in the village area goddess sri that so important quality nutrition given to child ages 6-24 months as MPASI because in Century it's exclusive breastfeeding just no enough Fulfill nutrition child for grow and develop optimally. Reluctantly increasing knowledge moms regarding MPASI which is very important for the golden age child in grow and develop optimally. So will many mothers who will give solids in the right way, and follow existing rules like give eat appropriate time it means given when child already ready for eat, with sufficient nutrition from various menu options and types rich food carbohydrates , proteins and fats. And all his served in circumstances hygienic and processed by the mother yourself and given in a manner responsive .

Temporal orienting of attention operates by biasing the allocation of cognitive and motor resources in specific moments in time, resulting in the improved processing of information from expected compared with unexpected targets. Recent findings have shown that temporal orienting operates relatively early across development, suggesting that this attentional mechanism plays a core role for human cognition. However, the exact neurophysiological mechanisms allowing children to attune their attention over time are not well understood. In this study, we presented 8- to 12-year-old children with a temporal cueing task designed to test (1) whether anticipatory oscillatory dynamics predict children's behavioral performance on a trial-by-trial basis and (2) whether anticipatory oscillatory neural activity may be supported by cross-frequency phase–amplitude coupling as previously shown in adults. Crucially, we found that, similar to what has been reported in adults, children's ongoing beta rhythm was strongly coupled with their theta rhythm and that the strength of this coupling distinguished validly cued temporal intervals, relative to neutral cued trials. In addition, in long trials, there was an inverse correlation between oscillatory beta power and children's trial-by-trial reaction, consistent with oscillatory beta power reflecting better response preparation. These findings provide the first experimental evidence that temporal attention in children operates by exploiting oscillatory mechanism.

Vitamin D receptors are widely expressed in brain tissue, including in the limbic system that plays a role in children's mental and emotional development. This study aimed to analyze the relationship between 25-(OH)-D level and children's mental-emotional development during their first 1000 days of life. A cross-sectional study was conducted on children aged ≤2 years old in Waled and Sukabumi regions using secondary data from previous cohort investigations entitled "The Role of Vitamin D in Efforts to Reduce Maternal and Infant mortality". The measurement of 25-(OH)-D concentration and assessment of the mental-emotional development were performed using the Ages and Stages Questionnaires: Social-Emotional (ASQ-SE) questionnaire. Other child and maternal characteristics, and several laboratory results, were also obtained. Statistical analyses were performed using the Spearman rank, Pearson correlation test, and multivariate linear regression analysis. A total of ninety-two children were included, and the median vitamin D level of the population was 20.17 ng/mL (IQR 4.43–49.97). The correlation analysis showed that no significant relationship between children's mental-emotional scores and the parameters tested, including the concentration of 25-(OH)-D (correlation coefficient 0.08; p=0.446). There was no relationship between the vitamin D concentration and mental-emotional development. Based on these results, it is concluded that there is no correlation between 25-(OH)-D concentration and children’s mental-emotional development during the first 1000 days of life. However, further investigations are recommended to eliminate various confounding factors.

Playing A Bike To Train The Rude Motor Ability Of Children Age 5-6 Years Old. During the Covid-19 pandemic, children with active characteristics will of course feel bored with games in the house that are less free. And children feel limited in exploring physical activities related to gross motor skills. Children at an early age are very important to carry out physical movements with the aim of stimulating the physical growth of children's motor skills, both fine and gross motor skills. To make children excited about doing physical activities, one of them is by inviting them to ride bikes together. In a joint cycling situation, direct observations can be made and also ask what children feel when playing a bicycle, the research conducted by the author uses a case study of a child aged 5-6 years who plays a two-wheeled bicycle with a focus on training the child's gross motor skills. , namely by locomotor, non-locomotor, and manipulative movements. From what has been done during the activity of playing bicycles, all of the movements made by children when playing bicycles have all referred to the gross motor skills of children, especially children aged 5-6 years.

ObjectivesPathogenetic mechanisms of hyperkinetic syndrome (HKS) or attention deficit hyperactivity disorder (ADHD) are not clear.AimTo elucidate some aspects of monoamine involvement in pathogenesis of disorder and response of monoaminergic systems to psychostimulant medication.MethodsLevels of different monoamines, their metabolites and N-methylnicotinamide (end product of kynurenine pathway) were measured in daily samples of urine from children (7–11 years old) with mild and severe HKS using fluorimetric and chromatographic methods as well as platelet monoamine oxidase (MAO) activity. Thirty children with mild HKS received psychostimulant Sydnocarb 5–15 mg daily for 1–1.5 months (for ethical reasons children with severe HKS were not included in study).ResultsHKS was accompanied by activation of dopaminergic and inhibition of noradrenergic systems. There were found metabolic differences between two forms of HKS. Compared with mild HKS, severe HKS was characterized by significant 2-fold increase of MAO activity and L-dopa, dopamine and adrenaline excretion. After sydnocarb treatment children's clinical status improved along with decrease of excretion of homovanillic, vanillylmandelic and 5-hydroxyindoleacetic acids and increase of N-methylnicotinamide.ConclusionsResults indicate that dopaminergic and noradrenergic systems play important role in pathogenesis of HKS. Clinical improvement of HKS children was accompanied by significant increase of N-methylnicotinamide excretion. It is proposed that increased urine excretion of kynurenine metabolite–N-methylnicotinamide and N-methylnicotinamide/5-hydroxyindoleacetic acid ratio can serve as potential biomarkers for evaluation of efficacy of psychostimulant medication. We hypothesize that kynurenine system plays significant role in pathogenesis of HKS/ADHD.Disclosure of interestThe authors have not supplied their declaration of competing interest.

Abstract Background: Fetal hemoglobin (HbF, α2g2) induction is known to reduce the clinical complications of sickle cell anemia (SCA). Progress in identifying novel HbF inducing strategies has been slowed by an incomplete understanding of gamma-globin regulation. We have used natural genetic variation to identify novel genes and pathways associated with HbF levels in patients with SCA, beginning with whole exome sequencing (WES). This approach identified FOXO3, a transcription factor important for insulin signaling and erythroid maturation, among other functions, as a positive regulator of HbF. We then confirmed the role of FOXO3 in HbF regulation with functional studies in erythroid culture (Zhang, Blood 2018). To overcome the limitations of WES, namely the absence of regulatory and promotor sequencing data, we performed whole genome sequencing (WGS) on 658 pediatric SCA patients, and analyzed the data for common variants predictive of HbF levels. Methods : WGS was performed on a cohort of 658 pediatric patients with HbSS and HbSβ0 with IRB approval from Texas Children's Hospital, and from St Jude Children's Research Hospital, as part of the Sickle Cell Clinical Research and Intervention Program (Hankins et al 2018). Baseline HbF levels, not on hydroxyurea therapy, was measured by HPLC. Subjects were between 6 months and 21 years of age from both institutions; 52% were male. We used mixed linear regression models to screen for variants associated with transformed HbF values, and performed ridge regression with 10-fold cross-validation to confirm associations after adjustment for HBG and BCL11A-associated variants, age, sex, and race (determined by principal components analysis). Hematopoietic stem and progenitor cells (HSPCs) from 3 patients (all HbSS) were treated with recombinant human IGFBP3 (1µg/ml) beginning on day 7 of two-phase culture. Effects of IGFBP3 on gamma-globin expression were evaluated by RT-qPCR, and on HbF levels by HPLC, on days 14 and 21 of culture. The effects of IGFBP3 on known modifiers of HbF and the FOXO3 pathway were assessed by RT-qPCR and western blot on day 21 of culture. Erythroid maturation was assessed by flow cytometry using anti-CD71, GPA, and Band3 on day 21 of culture. Results: Our whole genome sequencing data identified a strong association between all 11 variants 200 kb upstream of IGFBP3 and baseline HbF levels (p<1x10-9). The association of IGFBP3 variants with HbF remained after correcting for HBG and BCL11A variants in addition to patient age, sex, and race (p<0.001). Eleven SNPs were tested, and corrected for multiple testing. Mean HbF levels for patients heterozygous for an IGFBP3 variant predicted to alter IGFBP3 levels as determined by NESDA conditional eQTL catalog (Jenson et al, 2017) were 43% higher compared to patients without a variant (t-test p<0.0002). In erythroblasts treated with IGFBP3, gamma globin expression doubled compared to untreated (p=0.01). %HbF in IGFBP3 treated cells at day 21 of culture was the same as on day 14, while the HbF of untreated cells declined (Figure 1). IGFBP3 did not alter expression of known gamma globin regulators BCL11A, KLF1, and MYB, nor did it alter erythroid maturation as measured by flow cytometry with anti-CD71, GPA, and Band3, and morphologic examination. Conclusions: WGS analysis identified variants in the regulatory region of IGFBP3 as associated with higher levels of HbF. Addition of exogenous human recombinant IGFBP3 to HSPCs prevented the physiologic decline of HbF, resulting in higher %HbF levels in erythroblasts, functionally confirming the association. Exogenous IGFBP3 did not arrest maturation, supporting our hypothesis that IGFBP3 affects HbF production directly via gamma globin induction, rather than through manipulation of maturation. IGFBP3 did not alter expression of known regulators of HbF (BCL11A, KLF1, and MYB). These findings are compatible with our prior data identifying FOXO3 as a positive regulator of gamma globin, and our use of metformin as a HbF inducer in an ongoing clinical trial. Metformin increases IGFBP3 levels, and it has been shown that increases in IGFBP3 lead to activation of FOXO3 through the insulin signaling pathway. We therefore conclude that the insulin signaling pathway plays a significant role in gamma-globin regulation and is an important therapeutic target for HbF induction in patients with SCA. Disclosures Hankins: Global Blood Therapeutics: Research Funding; bluebird bio: Consultancy; Novartis: Research Funding; NCQA: Consultancy. Estepp:Global Blood Therapeutics: Consultancy, Research Funding; NHLBI: Research Funding; Daiichi Sankyo: Consultancy; ASH Scholar: Research Funding.

Play plays an important role in the child's emotional, cognitive, and physical development. Children play a role in social relations with social behavior, coming from the top of social conflict, social maturation, and self-esteem. The experiences gained while playing games give the child the ability to find solutions to the problems they face in the social environment. The game, which is the main object of amusement, has moved from the social environment to the virtual atmosphere as a result of technological developments. The main theme of this research is violent games, which are often played by children in elementary school age. Many have come up with the fact that violent visual and textual codes are being used. In this context, in regional surveys conducted in Bolu province, digital games played mostly by 8- to 12-year-old children were determined by face-to-face interview with children. Violent elements in these digital games have been discussed within the framework of relevant theoretical approaches through three games that children play most.