Relevant bibliographies by topics / Chimera

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Chimera'

Author: Grafiati
Published: 4 June 2021
Last updated: 10 March 2023

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Journal articles on the topic "Chimera"

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Chen, Wuyan, Zhi Xu, Annie Sullivan, Gabriela P. Finkielstain, Carol Van Ryzin, Deborah P. Merke, and Nazli B. McDonnell. "Junction Site Analysis of Chimeric CYP21A1P/CYP21A2 Genes in 21-Hydroxylase Deficiency." Clinical Chemistry 58, no. 2 (February 1, 2012): 421–30. http://dx.doi.org/10.1373/clinchem.2011.174037.

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Abstract BACKGROUND Chimeric CYP21A1P/CYP21A2 genes, caused by homologous recombination between CYP21A2 (cytochrome P450, family 21, subfamily A, polypeptide 2) and its highly homologous pseudogene CYP21A1P (cytochrome P450, family 21, subfamily A, polypeptide 1 pseudogene), are common in patients with congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency (21-OHD). A comprehensive junction site analysis of chimeric CYP21A1P/CYP21A2 genes is needed for optimizing genetic analysis strategy and determining clinical relevance. METHODS We conducted a comprehensive genetic analysis of chimeric CYP21A1P/CYP21A2 genes in a cohort of 202 unrelated 21-OHD patients. Targeted CYP21A2 mutation analysis was performed, and genotyping of chimeric CYP21A1P/CYP21A2 genes was cross-confirmed with Southern blot, RFLP, and multiplex ligation-dependent probe amplification analyses. Junction sites of chimera genes were determined by sequencing the long-PCR products amplified with primers CYP779f and Tena32F. An updated bioinformatics survey of Chi-like sequences was also performed. RESULTS Of 100 probands with a chimeric allele, 96 had a chimera associated with the severe classic salt-wasting form of CAH, and the remaining 4 carried an uncommon attenuated chimera with junction sites upstream of In2G (c.293–13A/C>G), which is associated with a milder phenotype. In addition to 6 of 7 reported chimeras, we identified a novel classic chimera (CH-8) and a novel attenuated chimera (CH-9). Attenuated chimeras explained prior genotype–phenotype discrepancies in 3 of the patients. Sequencing the CYP779f/Tena32F amplicons accurately differentiated between classic and attenuated chimeras. The bioinformatics survey revealed enrichment of Chi-like sequences within or in the vicinity of intron 2. CONCLUSIONS Junction site analysis can explain some genotype–phenotype discrepancies. Sequencing the well-established CYP779f/Tena32F amplicons is an unequivocal strategy for detecting attenuated chimeric CYP21A1P/CYP21A2 genes, which are clinically relevant.
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Sugawara, Kuniaki, Takumi Wakizuka, Atsushi Oowada, Takaya Moriguchi, and Mitsuo Omura. "Histogenic Identification by RAPD Analysis of Leaves and Fruit of Newly Synthesized Chimeric Citrus." Journal of the American Society for Horticultural Science 127, no. 1 (January 2002): 104–7. http://dx.doi.org/10.21273/jashs.127.1.104.

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Randomly amplified polymorphic DNA (RAPD) analysis was used to investigate the histogenic structure of leaf and fruit tissues in four graft chimeras, two intentional chimeras that were produced in combination with `Hamlin' orange [Citrus sinensis (L.) Osbeck] and `Satsuma' mandarin (C. unshiu Marc.), and two naturally occurring periclinal chimera cultivars, Kobayashi Mikan (a graft chimera of C. unshiu and C. natsudaidai Hayata), and Kinkoji Unshu (a graft chimera of C. unshiu and C. obovoidea hort. ex Takahashi). RAPD profiles of the lamina epidermis and the mesophyll cells of specific individuals indicated that the four graft chimeras were interspecific monekto chimeras, whose outermost layer (histogenic layer L-1) of the shoot apical meristem consisted of a species that was different from that in the inner layers (histogenic layers L-2 and L-3). Moreover, juice vesicles, which develop from the inside cells of the pericarp and become the main edible parts of Citrus fruit, were a mixture of the cells from both parental source cultivars. Therefore, the vesicles were at least composed of L-1 and subepidermal inner L-2 cells. This determination of interspecific chimeral construction (which was made possible by molecular techniques) is a valuable finding, in terms of improving Citrus through intentional use of periclinal chimerism.
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Kozikova, L., and E. Polteva. "New achievements in cell biology in poultry." Genetics and breeding of animals, no. 2 (August 26, 2022): 114–18. http://dx.doi.org/10.31043/2410-2733-2022-2-114-118.

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Purpose: development of new cell engineering in poultry farmingMaterials and methods. The following breeds of chickens were selected for research: Russian White, Minorca, Light Brahma and Fawn Brahma in comparison with the interspecific chimera of Japanese quail and Beijing duck. All chimeras were obtained by transplantation in the latter case of primary germ cells, in other breeds of blastodermal cells into the sub-embryonic region of recipient embryos. All embryonic cells before transplantation were cultivated for two days in special culture media supplemented with fetal cow serum and antibiotics. Chimeras were identified by the presence of contrasting feathers, unusual for this breed.Results. Unlike mammals, birds have a completely different embryonic development, which requires the development of new developments in cell biology to obtain chimeric birds. There are intrabreed chimeras and interspecies, obtained from organisms of different species. As an example of an interspecific chimera, a chimera of a Japanese quail and a Peking duck with a chimeric phenotype of black feathers on the neck is presented. Primary germ cells of Japanese quail served as donors. We obtained interbreeding chimeras of light and yellow brahma, when the donors were blastodermal cells of the light brahma, and the recipients were early embryos of the fawn brahma. Another variant of chimeras were chimeras between the breeds Russian White (donor blastodermal cells) and Minorca (embryo recipient).Conclusion. The observed sharp decline in the number of bird breeds requires new approaches to their conservation and the creation of new genetic organisms. With the help of modern developments in cell biology, it has become possible to create a new strategy for obtaining chimeric birds. The use of pluripotent embryonic cells has led to the creation of interbreed and interspecies bird chimeras.
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Ebrahimzadeh, P., M. Schiek, P. Jaros, T. Kapitaniak, S. van Waasen, and Y. Maistrenko. "Minimal chimera states in phase-lag coupled mechanical oscillators." European Physical Journal Special Topics 229, no. 12-13 (September 2020): 2205–14. http://dx.doi.org/10.1140/epjst/e2020-900270-4.

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Abstract We obtain experimental chimera states in the minimal network of three identical mechanical oscillators (metronomes), by introducing phase-lagged all-to-all coupling. For this, we have developed a real-time model-in-the-loop coupling mechanism that allows for flexible and online change of coupling topology, strength and phase-lag. The chimera states manifest themselves as a mismatch of average frequency between two synchronous and one desynchronized oscillator. We find this kind of striking “chimeric” behavior is robust in a wide parameter region. At other parameters, however, chimera state can lose stability and the system behavior manifests itself as a heteroclinic switching between three saddle-type chimeras. Our experimental observations are in a qualitative agreement with the model simulation.
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Slack, Jeffrey M., Edward M. Dougherty, and Susan D. Lawrence. "A study of the Autographa californica multiple nucleopolyhedrovirus ODV envelope protein p74 using a GFP tag." Journal of General Virology 82, no. 9 (September 1, 2001): 2279–87. http://dx.doi.org/10.1099/0022-1317-82-9-2279.

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The Autographa californica multiple nucleopolyhedrovirus (AcMNPV) protein p74 is associated with the occlusion-derived virus (ODV) envelope. p74 is essential for oral infectivity of ODV and has been proposed to play a role in midgut attachment and/or fusion. In this study, p74 protein was expressed in-frame with green fluorescent protein (GFP) to create a p74–GFP chimera. The C-terminal GFP portion of the chimera facilitated visualization of the trafficking of p74 in baculovirus-infected Spodoptera frugiperda (Sf-9) cells. p74–GFP chimeric proteins localized in the intranuclear ring zone of the nucleus and were found to co-precipitate with the microvesicle fraction of cell lysates. A series of truncations of p74 was expressed as p74–GFP chimeras in recombinant baculoviruses. When C-terminal region S580–F645 was deleted from p74, p74–GFP chimera localization became non-specific and chimeras became soluble. p74 region S580–F645 directed GFP to the intranuclear ring zone in a similar pattern to full-length p74. The hydrophobic C terminus of p74 plays a role in protein localization and possibly in transmembrane anchoring and insertion.
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Zakharova, Anna, Marie Kapeller, and Eckehard Schöll. "Amplitude chimeras and chimera death in dynamical networks." Journal of Physics: Conference Series 727 (June 2016): 012018. http://dx.doi.org/10.1088/1742-6596/727/1/012018.

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Wataghin, Lucia. "La Chimera di Dino Campana e Altre Chimere." Revista de Italianística, no. 16 (August 30, 2008): 37. http://dx.doi.org/10.11606/issn.2238-8281.v0i16p37-43.

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Patidar, Manoj, Naveen Yadav, and Sarat K. Dalai. "Influence of Length and Amino Acid Composition on Dimer Formation of Immunoglobulin based Chimera." Current Pharmaceutical Design 24, no. 11 (June 27, 2018): 1211–23. http://dx.doi.org/10.2174/1381612823666171018115206.

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Background: The dimeric immunoglobulin (Ig) chimeras used for drug targeting and delivery are preferred biologics over their monomeric forms. Designing these Ig chimeras involves critical selection of a suitable Ig base that ensures dimer formation. In the present study, we systematically analyzed several factors that influence the formation of dimeric chimera. We designed and predicted 608 cytokine-Ig chimeras where we tested the contributions of (1) different domains of Ig constant heavy chain, (2) length of partner proteins, (3) amino acid (AA) composition and (4) position of cysteine in the formation of homodimer. Method: The sequences of various Ig and cytokines were procured from Uniprot database, fused and submitted to COTH (CO-THreader) server for the prediction of dimer formation. Contributions of different domains of Ig constant heavy chain, length of chimeric proteins, AA composition and position of cysteine to the homodimer formation of 608 cytokine-Ig chimeras were tested. Various in silico approaches were adopted for validating the in silico findings. Experimentally we also validated our approach by expressing the chimeric design of shorter cytokine with Ig domain in CHO cells and analyzing the protein by SDS-PAGE. Results: Our results advocate that while the CH1 region and the Hinge region of Ig heavy chain are critical, the length of partner proteins also crucially influences homodimer formation of the Ig-based chimera. We also report that the CH1 domain of Ig is not required for dimer formation of Ig based chimera in the presence of larger partner proteins. For shorter partner proteins fused to CH2-CH3, careful selection of partner sequence is critical, particularly the hydrophobic AA composition, cysteine content & their positions, disulphide bond formation property, and the linker sequences. We validated our in silico observation by various bioinformatics tools and checked the ability of chimeras to bind with the receptors of native protein by docking studies. As a proof of concept, we have expressed the chimeric proteins in CHO cells and found that our design favors the synthesis of dimeric proteins. Conclusion: Our structural prediction study suggests that extra amino acids in the range of 15-20 added to the CH2 domain of Ig is a critical requirement to make homodimer. This information from our study will have implication in designing efficacious homodimeric chimera.
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Pham, Quynh N., Stéphane Biacchesi, Mario H. Skiadopoulos, Brian R. Murphy, Peter L. Collins, and Ursula J. Buchholz. "Chimeric Recombinant Human Metapneumoviruses with the Nucleoprotein or Phosphoprotein Open Reading Frame Replaced by That of Avian Metapneumovirus Exhibit Improved Growth In Vitro and Attenuation In Vivo." Journal of Virology 79, no. 24 (December 15, 2005): 15114–22. http://dx.doi.org/10.1128/jvi.79.24.15114-15122.2005.

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ABSTRACT Chimeric versions of recombinant human metapneumovirus (HMPV) were generated by replacing the nucleoprotein (N) or phosphoprotein (P) open reading frame with its counterpart from the closely related avian metapneumovirus (AMPV) subgroup C. In Vero cells, AMPV replicated to an approximately 100-fold-higher titer than HMPV. Surprisingly, the N and P chimeric viruses replicated to a peak titer that was 11- and 25-fold higher, respectively, than that of parental HMPV. The basis for this effect is not known but was not due to obvious changes in the efficiency of gene expression. AMPV and the N and P chimeras were evaluated for replication, immunogenicity, and protective efficacy in hamsters. AMPV was attenuated compared to HMPV in this mammalian host on day 5 postinfection, but not on day 3, and only in the nasal turbinates. In contrast, the N and P chimeras were reduced approximately 100-fold in both the upper and lower respiratory tract on day 3 postinfection, although there was little difference by day 5. The N and P chimeras induced a high level of neutralizing serum antibodies and protective efficacy against HMPV; AMPV was only weakly immunogenic and protective against HMPV challenge, reflecting antigenic differences. In African green monkeys immunized intranasally and intratracheally, the mean peak titer of the P chimera was reduced 100- and 1,000-fold in the upper and lower respiratory tracts, whereas the N chimera was reduced only 10-fold in the lower respiratory tract. Both chimeras were comparable to wild-type HMPV in immunogenicity and protective efficacy. Thus, the P chimera is a promising live HMPV vaccine candidate that paradoxically combines improved growth in vitro with attenuation in vivo.
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Cairns, Tina M., Richard S. B. Milne, Manuel Ponce-de-Leon, Deanna K. Tobin, Gary H. Cohen, and Roselyn J. Eisenberg. "Structure-Function Analysis of Herpes Simplex Virus Type 1 gD and gH-gL: Clues from gDgH Chimeras." Journal of Virology 77, no. 12 (June 15, 2003): 6731–42. http://dx.doi.org/10.1128/jvi.77.12.6731-6742.2003.

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ABSTRACT In alphaherpesviruses, glycoprotein B (gB), gD, gH, and gL are essential for virus entry. A replication-competent gL-null pseudorabies virus (PrV) (B. G. Klupp and T. C. Mettenleiter, J. Virol. 73:3014-3022, 1999) was shown to express a gDgH hybrid protein that could replace gD, gH, and gL in cell-cell fusion and null virus complementation assays. To study this phenomenon in herpes simplex virus type 1 (HSV-1), we constructed four gDgH chimeras, joining the first 308 gD amino acids to various gH N-terminal truncations. The chimeras were named for the first amino acid of gH at which each was truncated: 22, 259, 388, and 432. All chimeras were immunoprecipitated with both gD and gH antibodies to conformational epitopes. Normally, transport of gH to the cell surface requires gH-gL complex formation. Chimera 22 contains full-length gH fused to gD308. Unlike PrV gDgH, chimera 22 required gL for transport to the surface of transfected Vero cells. Interestingly, although chimera 259 failed to reach the cell surface, chimeras 388 and 432 exhibited gL-independent transport. To examine gD and gH domain function, each chimera was tested in cell-cell fusion and null virus complementation assays. Unlike PrV gDgH, none of the HSV-1 chimeras substituted for gL for fusion. Only chimera 22 was able to replace gH for fusion and could also replace either gH or gD in the complementation assay. Surprisingly, this chimera performed very poorly as a substitute for gD in the fusion assay despite its ability to complement gD-null virus and bind HSV entry receptors (HveA and nectin-1). Chimeras 388 and 432, which contain the same portion of gD as that in chimera 22, substituted for gD for fusion at 25 to 50% of wild-type levels. However, these chimeras functioned poorly in gD-null virus complementation assays. The results highlight the fact that these two functional assays are measuring two related but distinct processes.
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Dissertations / Theses on the topic "Chimera"

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Tobe, Rachel. "The Chimera." University of Cincinnati / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1495807870248537.

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Hatleback, Eric Nelson. "Chimera of the cosmos." Thesis, University of Pittsburgh, 2015. http://pqdtopen.proquest.com/#viewpdf?dispub=3647982.

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Multiverse cosmology exhibits unique epistemic problems because it posits the existence of universes inaccessible from our own. Since empirical investigation is not possible, philosophical investigation takes a prominent role. The inaccessibility of the other universes causes argumentation for the multiverse hypothesis to be wholly dependent upon typicality assumptions that relate our observed universe to the unobserved universes. The necessary reliance on typicality assumptions results in the Multiverse Circularity Problem: the multiverse hypothesis is justified only through invoking typicality assumptions, but typicality assumptions are justified only through invoking the multiverse hypothesis. The unavoidability of the circularity is established through argumentation for each of the two conjuncts that comprise it.

Historical investigation proves the first conjunct of the Multiverse Circularity Problem. Detailed study of the now-neglected tradition of multiverse thought shows that philosophers and scientists have postulated the multiverse hypothesis with regularity, under different names, since antiquity. The corpus of argumentation for the existence of the multiverse breaks cleanly into three distinct argument schemas: implication from physics, induction, and explanation. Each of the three argument schemas is shown to be fully reliant upon unsupported typicality assumptions. This demonstrates that the multiverse hypothesis is justified only through invoking typicality assumptions.

Philosophical assessment of cosmological induction establishes the second conjunct of the Multiverse Circularity Problem. Independent justification for typicality assumptions is not forthcoming. The obvious candidate, enumerative induction, fails: Hume’s attack against inference through time is extended to inference through space. This move undercuts external justification for typicality assumptions, such as the Cosmological Principle, which cosmologists implement to justify induction. Removing the legitimacy of enumerative induction shows that typicality assumptions are justified only through invoking the multiverse hypothesis, thereby establishing the Multiverse Circularity Problem.

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Envall, Pelle. "Accessibility planning : a chimera?" Thesis, University of Leeds, 2007. http://etheses.whiterose.ac.uk/11279/.

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This thesis investigates whether Accessibility Planning is a chimera. Is Accessibility Planning an illusion without reality, or is it a feasible planning Concept? Are accessibility-based planning approaches not already included in Mainstream transport planning practice? The objectives of the study are explored Through literature' reviews' and primary research of planning practitioners and Pedestrians. The literature reviews identify a number of potential barriers to Accessibility Planning through assessing research literature and collecting Information on previously abandoned approaches that were similar in scope to Accessibility Planning. The potential barriers were rephrased into eight research Propositions, divided into two groups, culture and tools. A further literature review And two surveys seek to answer the propositions. A survey of transport planners in British local authorities investigates difficulties in implementing Accessibility Planning and planners' attitudes to it. A second survey uses questionnaires and an Innovative GIS-based analysis to examine pedestrian route choice. The evidence Collected by the new GIS methodology assesses the reliability of 'local' Accessibility indicators based solely on notional distance. This part of the study also Presents new evidence on pedestrian route choice behaviour. Finally, the findings From the two surveys and the literature reviews are brought together and used to Confirm or reject the propositions. The results of the study portray how British. Transport planning culture has changed to take up an accessibility-based planning Approach and where the strengths and weaknesses of Accessibility Planning lie. The Study concluded that Accessibility Planning is not a chimera and that the tools that Have dominated transport planning do not incorporate an accessibility-based Planning approach. It also found that there is a significant problem in specifying Useful accessibility indicators, that this is an obstacle for effective Accessibility Planning, and that Accessibility Planning requires new skills and ways of working.
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Galbraith, Marshall C. "A Discontinuous Galerkin Chimera Overset Solver." University of Cincinnati / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1384427339.

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Ruzzene, Giulia. "Control of chimera states in oscillator networks." Doctoral thesis, Universitat Pompeu Fabra, 2020. http://hdl.handle.net/10803/669638.

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Partial synchronization is an important phenomenon observed in nature and model systems. Chimera states are the most studied type of partially synchronized dynamics and attract interest from many fields of science. In homogeneous networks of identical oscillators, a chimera state is a symmetry broken dynamics in which the oscillators spontaneously split into two complementary groups: one in which they are synchronized and one in which they are not. The quest for chimera states in real-world scenarios has been made challenging by their unstable nature in systems of finite size. Therefore, it became crucial to find ways to control them. In this thesis we propose a new control method based on a pacemaker oscillator. We show how it can control all of the chimeras’ instabilities in networks of phase oscillators and we generalized this concept to more complex scenarios by applying it to multiplex networks of phase and FitzHugh-Nagumo oscillators.
La sincronització parcial és un fenomen que s'observa en la naturalesa i en models matemàtics. Els anomenats estats quimera són entre els exemples més estudiats de sincronització parcial i atrauen l'interès de molts àmbits científics. En xarxes homogènies d’oscil·ladors idèntics, un estat quimera és una dinàmica en què es trenca la simetria perquè els oscil·ladors es divideixen espontàniament en dos grups complementaris: en un grup estan sincronitzats i en l'altre no. La cerca d’estats de quimera en escenaris del món real s’ha vist dificultada per la seva naturalesa inestable en sistemes finits. Per tant, és crucial trobar formes de controlar-les. En aquesta tesi proposem un nou mètode de control que utilitza un pacemaker (oscil·lador marcapassos). Mostrem com el pacemaker pot controlar totes les inestabilitats de les quimeres en xarxes d’oscil·ladors de fase i generalitzem aquest concepte a escenaris més complexos aplicant-lo a xarxes formades per capes d’oscil·ladors de fases i models de neurones de FitzHugh-Nagumo.
La sincronización parcial es un fenómeno importante que se observa en la naturaleza y en modelos matemáticos. Los denominados estados quimera son el tipo m\'as estudiado de dinámica parcialmente sincronizada y atraen el interés de muchos campos de la ciencia. En redes homogéneas de osciladores idénticos, un estado quimera es una dinámica con simetría rota en la que los osciladores se dividen espontáneamente en dos grupos complementarios: en uno están sincronizados y en el otro no. La investigación de estados quimera en escenarios reales se ha convertido en un desafío por su naturaleza inestable en sistemas finitos. Por lo tanto, es crucial encontrar forma de controlarlos. En esta tesis proponemos un nuevo método de control basado en un oscilador marcapasos (pacemaker). Mostramos cómo esto puede controlar las inestabilidades de las quimeras en redes de osciladores de fase y generalizamos el concepto a escenarios más complejos al aplicarlo a redes multi-capa de osciladores de fase y de modelos de neuronas de FitzHugh-Nagumo.
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Drozdek, Justyna. "Life and Chimera framing modernism in Poland /." online version, 2008. http://rave.ohiolink.edu/etdc/view.cgi?acc%5Fnum=case1212425287.

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Mayor, Olivier. "Lineage analysis of neurogenesis in mouse chimera." Thesis, McGill University, 1989. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=59410.

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To investigate the lineage relationships that are postulated to underlie the origins of phenotypically different neurons, Thy-1.1 $ leftrightarrow$ Thy-1.2 and hNF-L $ leftrightarrow$ +/+ mouse chimeras were examined for the distribution of the two neuron genotypes. Throughout the nervous system, a finely variegated pattern of mosaicism was always observed and, in each chimera, similar genotype proportions were found in all analysed neuronal populations of the peripheral and central nervous system. These findings require that the chimera neuroectoderm was a homogeneous mix of the two genotypes and that different neuronal phenotypes do not arise clonally from a small number of prespecified progenitors. Rather it would seem that all progenitors contribute daughter cells to all of the neuronal subpopulations at each level of the neuroaxis.
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Goh, Leong H. "The Chimera of the Asean regional security community." Thesis, Monterey, Calif. : Springfield, Va. : Naval Postgraduate School ; Available from National Technical Information Service, 1999. http://handle.dtic.mil/100.2/ADA371203.

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Thesis (M.A. in National Security Affairs) Naval Postgraduate School, December 1999.
"December 1999". Thesis advisor(s): Mary P. Callahan. Includes bibliographical references (p. 113-117). Also available online.
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Herrmann, Anke. "Predicting nitrogen mineralization from soil organic matter - a chimera? /." Uppsala : Dept. of Soil Sciences, Swedish Univ. of Agricultural Sciences, 2003. http://epsilon.slu.se/a429.pdf.

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Anderson, Graham. "Organisational culture in English further education : chimera or substance." Thesis, University of Warwick, 2007. http://wrap.warwick.ac.uk/1115/.

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Since the mid-1970s there has been a greater emphasis placed on markets and competition as a means of allocating scarce resources. As a consequence of this the provision of public services has come under close scrutiny. In the English further education sector there has been structural and strategic change. The further education (FE) colleges are positioned to be able to play a key role in· the economic and social regeneration of the UK. The development- of 'managerialism' has occasioned the use of many practices and procedures more commonly associated with the private sector provision of goods and services. This study examines whether the concept of organizational culture has meaning and validity in a further education context. Research in this area is complex, time consuming and expensive. The concept of organizational culture is examined and evidence is gathered from a case study in Templeton College. The analysis of the evidence employs some of Pierre Bourdieu's concepts of the social world: field habitus and game. The evidence suggests that there is no integrated pattern of shared beliefs or behaviours that can claim to be a distinct entity. External factors are more likely to determine the situated social practices that exist within colleges. The case study approach has limited the external validity of the research and further analysis of . colleges is needed to verify the claims in this thesis. The study demonstrates that the migration of private sector management practices and concepts to the public sector is not an unproblematic process. FE would benefit from more extensive practitioner research; the more widely and deeply the colleges understand themselves the better chance for securing lasting improvements. Organizational culture is unlikely to be a significant lever of change in FE and colleges may be better advised to build a teaching and learning ethos.
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Books on the topic "Chimera"

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Chimera. New York: Tor, 2001.

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Carroll, Lois. Chimera. Waterville, Me: Five Star, 2006.

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Chimera. New York: Tor, 2000.

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Chimera. Bologna: Coconino Press, 2011.

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Chimera. Sevenoaks: New English Library, 1990.

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Chimera. New York, NY: Orbit, 2012.

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Slade, Jan. Chimera. Cardigan: Parthian, 2009.

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John, Barth. Chimera. New York: Ballantine Books, 1988.

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Rachael, Thomas, Jackson Georgina, and Irish Museum of Modern Art (Kilmainham, Dublin, Ireland), eds. Chimera. Dublin: Irish Museum of Modern Art, 2008.

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(Firm), UE Books, ed. Chimera. Forest Park, Ill: UE Books, 2015.

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Book chapters on the topic "Chimera"

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Hoyer, Daniel, Eric P. Zorrilla, Pietro Cottone, Sarah Parylak, Micaela Morelli, Nicola Simola, Nicola Simola, et al. "Chimera." In Encyclopedia of Psychopharmacology, 278. Berlin, Heidelberg: Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-540-68706-1_634.

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Frasca, Mattia, Lucia Valentina Gambuzza, Arturo Buscarino, and Luigi Fortuna. "Chimera States." In Synchronization in Networks of Nonlinear Circuits, 39–56. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-75957-9_3.

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Hawthorne, Nathaniel. "The Chimera." In Red Magic, 139–53. London: Routledge, 2022. http://dx.doi.org/10.4324/9781003297482-18.

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Tabone-Weil, Dominique. "The Chimera." In Psychoanalysts in Session, 85–87. Abingdon, Oxon; New York, NY: Routledge, 2021. | Series: The new library of psychoanalysis | “Published in French, 2016”–Title page verso.: Routledge, 2020. http://dx.doi.org/10.4324/9780429196751-3d.

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Nute, Kevin. "A built chimera." In The Constructed Other, 1–4. London: Routledge, 2021. http://dx.doi.org/10.4324/9780429423222-001.

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Walker, Stuart. "The Chimera Reified." In The Spirit of Design, 97–110. London: Routledge, 2021. http://dx.doi.org/10.4324/9781849776769-8.

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Totz, Jan Frederik. "Spiral Wave Chimera." In Springer Theses, 55–97. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-11057-4_4.

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Zakharova, Anna. "Amplitude Chimeras and Chimera Death in Ring Networks." In Understanding Complex Systems, 37–95. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-21714-3_2.

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Cwykiel, Joanna, and Maria Z. Siemionow. "In Vivo Chimera Model: Creation of Primary and Secondary Chimera." In Plastic and Reconstructive Surgery, 581–91. London: Springer London, 2014. http://dx.doi.org/10.1007/978-1-4471-6335-0_71.

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Meo, Rosa, Giuseppe Psaila, and Stefano Ceri. "Composite events in Chimera." In Advances in Database Technology — EDBT '96, 56–76. Berlin, Heidelberg: Springer Berlin Heidelberg, 1996. http://dx.doi.org/10.1007/bfb0014143.

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Conference papers on the topic "Chimera"

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Minhas, Umar Farooq, David Lomet, and Chandramohan A. Thekkath. "Chimera." In the 15th Symposium. New York, New York, USA: ACM Press, 2011. http://dx.doi.org/10.1145/2076623.2076642.

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Anderson, Kenneth M., Richard N. Taylor, and E. James Whitehead. "Chimera." In the 1994 ACM European conference. New York, New York, USA: ACM Press, 1994. http://dx.doi.org/10.1145/192757.192783.

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Park, Jason Jong Kyu, Yongjun Park, and Scott Mahlke. "Chimera." In ASPLOS '15: Architectural Support for Programming Languages and Operating Systems. New York, NY, USA: ACM, 2015. http://dx.doi.org/10.1145/2694344.2694346.

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Lee, Dongyoon, Peter M. Chen, Jason Flinn, and Satish Narayanasamy. "Chimera." In the 33rd ACM SIGPLAN conference. New York, New York, USA: ACM Press, 2012. http://dx.doi.org/10.1145/2254064.2254119.

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Li, Shigang, and Torsten Hoefler. "Chimera." In SC '21: The International Conference for High Performance Computing, Networking, Storage and Analysis. New York, NY, USA: ACM, 2021. http://dx.doi.org/10.1145/3458817.3476145.

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LIJEWSKI, LAWRENCE, and NORMAN SUHS. "Chimera-EAGLE store separation." In Astrodynamics Conference. Reston, Virigina: American Institute of Aeronautics and Astronautics, 1992. http://dx.doi.org/10.2514/6.1992-4569.

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Zhao, Xiang, and Sijun Zhang. "An Overset Chimera Unstructured Grid Method and Its Applications." In ASME/JSME 2007 5th Joint Fluids Engineering Conference. ASMEDC, 2007. http://dx.doi.org/10.1115/fedsm2007-37124.

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In this paper, an overset Chimera method is extended to unstructured mesh, the unstructured grid solver enhanced by the overset Chimera method is employed to various specific applications, in which time dependent fluid flows involving multiple moving bodies needs to be solved. The present method possesses not only the novel feature of Chimera method but also the advantage of unstructured grid approach. Its robustness and efficiency are illustrated in this paper through typical applications.
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English, R. Elliot, Linhai Qiu, Yue Yu, and Ronald Fedkiw. "Chimera grids for water simulation." In the 12th ACM SIGGRAPH/Eurographics Symposium. New York, New York, USA: ACM Press, 2013. http://dx.doi.org/10.1145/2485895.2485897.

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Nicola, Mario, Beatrice Motella, and Micaela Troglia Gamba. "The Chimera solution: performance assessment." In 2020 European Navigation Conference (ENC). IEEE, 2020. http://dx.doi.org/10.23919/enc48637.2020.9317338.

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Aiello, S., A. Anzalone, M. Bartolucci, M. G. Campisi, G. Cardella, Sl Cavallaro, E. De Filippo, et al. "The Chimera Facility at LNS." In Experimental nuclear physics in europe: Facing the next millennium. AIP, 1999. http://dx.doi.org/10.1063/1.1301817.

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Reports on the topic "Chimera"

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Lin, Cheng-Wen, Scott Percival, and Eugene H. Gotimer. Application of Chimera Composite Grid Scheme to Ship Appendages. Fort Belvoir, VA: Defense Technical Information Center, January 1995. http://dx.doi.org/10.21236/ada400727.

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Edge, Harris L., and Jubaraj Sahu. Computational Modeling of a Finned Projectile by Chimera Technique. Fort Belvoir, VA: Defense Technical Information Center, December 1997. http://dx.doi.org/10.21236/ada334011.

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Wang, Y. A Three-Dimensional Inviscid Flow Solver in Chimera Flow Simulation. Fort Belvoir, VA: Defense Technical Information Center, February 1994. http://dx.doi.org/10.21236/ada294176.

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Velappan, Nileena. Construction, characterization and crystal structure of a fluorescent single-chain Fv chimera. Office of Scientific and Technical Information (OSTI), March 2021. http://dx.doi.org/10.2172/1771063.

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Dolja, Valerian V., Amit Gal-On, and Victor Gaba. Suppression of Potyvirus Infection by a Closterovirus Protein. United States Department of Agriculture, March 2002. http://dx.doi.org/10.32747/2002.7580682.bard.

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The plant virus family Polyviridae is the largest and most destructive of all plant viruses. Despite the continuous effort to develop resistant plant varieties, there is a desperate need for novel approaches conferring wide-range potyvirus resistance. Based on experiments with the tobacco etch potyvirus (TEV)-derived gene expression vector, we suggested approach for screening of the candidate resistance genes. This approach relies on insertion of the genes into a virus vector and evaluation of the phenotypes of the resulting recombinant viruses. The genes which suppress infection by the recombinant virus are selected as candidates for engineering transgenic resistance. Our analysis of the TEV variants expressing proteins of the beet yellows closterovirus (BYV) revealed that one of those, the leader proteinase (L-Pro), strongly and specifically interfered with the hybrid TEV infection. Since closterovirus L-Pro is evolutionary related to potyviral helper component-proteinase (HC-Pro), we suggested that the L-Pro interfered with HC-Pro function via a trans-dominant inhibitory effect. Based on these findings, we proposed to test two major hypotheses. First, we suggested that L-Pro-mediated suppression of potyvirus infection is a general phenomenon effective against a range of potyviruses. The second hypothesis stated that the suppression effect can be reproduced in transgenic plants expressing L-Pro, and can be utilized for generation of resistance to potyviruses. In accord with these hypotheses, we developed two original objectives of our proposal: A) to determine the range of the closterovirus-derived suppression of potyviral infection, and B) to try and utilize the L-Pro-mediated suppression for the development of transgenic resistance to potyviruses. In the first phase of the project, we have developed all major tools and technologies required for successful completion of the proposed research. These included TEV and ZYMV vectors engineered to express several closteroviral L-Pro variants, and generation of the large collection of transgenic plants. To our satisfaction, characterization of the infection phenotypes exhibited by chimeric TEV and ZYMV variants confirmed our first hypothesis. For instance, similar to TEV-L- Pro(BYV) chimera, ZYMV-L-Pro(LIYV) chimera was debilitated in its systemic spread. In contrast, ZYMV-GUS chimera (positive control) was competent in establishing vigorous systemic infection. These and other results with chimeric viruses indicated that several closteroviral proteinases inhibit long-distance movement of the potyviruses upon co-expression in infected plants. In order to complete the second objective, we have generated ~90 tobacco lines transformed with closteroviral L-Pro variants, as well as ~100 lines transformed with BYV Hsp70-homolog (Hsp70h; a negative control). The presence and expression of the trans gene in each line was initially confirmed using RT-PCR and RNA preparations isolated from plants. However, since detection of the trans gene-specific RNA can not guarantee production of the corresponding protein, we have also generated L-Pro- and Hsp70h-specific antisera using corresponding synthetic peptides. These antisera allowed us to confirm that the transgenic plant lines produced detectable, although highly variable levels of the closterovirus antigens. In a final phase of the project, we tested susceptibility of the transgenic lines to TEV infection. To this end, we determined that the minimal dilution of the TEV inoculum that is still capable of infecting 100% of nontransgenic plants was 1:20, and used 10 plants per line (in total, ~2,000 plants). Unfortunately, none of the lines exhibited statistically significant reduction in susceptibility. Although discouraging, this outcome prompted us to expand our experimental plan and conduct additional experiments. Our aim was to test if closteroviral proteinases are capable of functioning in trans. We have developed agroinfection protocol for BYV, and tested if co- expression of the L-Pro is capable of rescuing corresponding null-mutant. The clear-cut, negative results of these experiments demonstrated that L-Pro acts only in cis, thus explaining the lack of resistance in our transgenic plants. We have also characterized a collection of the L-Pro alanine- scanning mutants and found direct genetic evidence of the requirement for L-Pro in virus systemic spread. To conclude, our research supported by BARD confirmed one but not another of our original hypotheses. Moreover, it provided an important insight into functional specialization of the viral proteinases and generated set of tools and data with which we will be able to address the molecular mechanisms by which these proteins provide a variety of critical functions during virus life cycle.
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Rafaeli, Ada, Russell Jurenka, and Chris Sander. Molecular characterisation of PBAN-receptors: a basis for the development and screening of antagonists against Pheromone biosynthesis in moth pest species. United States Department of Agriculture, January 2008. http://dx.doi.org/10.32747/2008.7695862.bard.

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The original objectives of the approved proposal included: (a) The determination of species- and tissue-specificity of the PBAN-R; (b) the elucidation of the role of juvenile hormone in gene regulation of the PBAN-R; (c) the identificationof the ligand binding domains in the PBAN-R and (d) the development of efficient screening assays in order to screen potential antagonists that will block the PBAN-R. Background to the topic: Moths constitute one of the major groups of pest insects in agriculture and their reproductive behavior is dependent on chemical communication. Sex-pheromone blends are utilised by a variety of moth species to attract conspecific mates. In most of the moth species sex-pheromone biosynthesis is under circadian control by the neurohormone, PBAN (pheromone-biosynthesis-activating neuropeptide). In order to devise ideal strategies for mating disruption/prevention, we proposed to study the interactions between PBAN and its membrane-bound receptor in order to devise potential antagonists. Major conclusions: Within the framework of the planned objectives we have confirmed the similarities between the two Helicoverpa species: armigera and zea. Receptor sequences of the two Helicoverpa spp. are 98% identical with most changes taking place in the C-terminal. Our findings indicate that PBAN or PBAN-like receptors are also present in the neural tissues and may represent a neurotransmitter-like function for PBAN-like peptides. Surprisingly the gene encoding the PBAN-receptor was also present in the male homologous tissue, but it is absent at the protein level. The presence of the receptor (at the gene- and protein-levels), and the subsequent pheromonotropic activity are age-dependent and up-regulated by Juvenile Hormone in pharate females but down-regulated by Juvenile Hormone in adult females. Lower levels of pheromonotropic activity were observed when challenged with pyrokinin-like peptides than with HezPBAN as ligand. A model of the 3D structure of the receptor was created using the X-ray structure of rhodopsin as a template after sequence alignment of the HezPBAN-R with several other GPCRs and computer simulated docking with the model predicted putative binding sites. Using in silico mutagenesis the predicted docking model was validated with experimental data obtained from expressed chimera receptors in Sf9 cells created by exchanging between the three extracellular loops of the HezPBAN-R and the Drosophila Pyrokinin-R (CG9918). The chimera receptors also indicated that the 3ʳᵈ extracellular loop is important for recognition of PBAN or Diapause hormone ligands. Implications: The project has successfully completed all the objectives and we are now in a position to be able to design and screen potential antagonists for pheromone production. The successful docking simulation-experiments encourage the use of in silico experiments for initial (high-throughput) screening of potential antagonists. However, the differential responses between the expressed receptor (Sf9 cells) and the endogenous receptor (pheromone glands) emphasize the importance of assaying lead compounds using several alternative bioassays (at the cellular, tissue and organism levels). The surprising discovery of the presence of the gene encoding the PBAN-R in the male homologous tissue, but its absence at the protein level, launches opportunities for studying molecular regulation pathways and the evolution of these GPCRs. Overall this research will advance research towards the goal of finding antagonists for this important class of receptors that might encompass a variety of essential insect functions.
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Omenetto, Fiorenzo, and David L. Kaplan. Dynamic Camouflage Materials Based on Silk-Reflectin Chimeras. Fort Belvoir, VA: Defense Technical Information Center, August 2012. http://dx.doi.org/10.21236/ada567581.

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Liao, Dezhong. RNA Chimeras as a Gene Signature of Breast Cancer. Fort Belvoir, VA: Defense Technical Information Center, June 2014. http://dx.doi.org/10.21236/ada612049.

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Liao, D. J. RNA Chimeras as a Gene Signature of Breast Cancer. Fort Belvoir, VA: Defense Technical Information Center, May 2013. http://dx.doi.org/10.21236/ada582144.

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Migliori, Amy Davenport. Chimeric Protein Treatment of Pierce Disease. Office of Scientific and Technical Information (OSTI), June 2020. http://dx.doi.org/10.2172/1634942.

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