Relevant bibliographies by topics / Chimeric competency

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Reports

Academic literature on the topic 'Chimeric competency'

Author: Grafiati
Published: 21 December 2024
Last updated: 31 July 2025

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Journal articles on the topic "Chimeric competency"

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Strell, Phoebe, Anala Shetty, Clifford J. Steer, and Walter C. Low. "Interspecies Chimeric Barriers for Generating Exogenic Organs and Cells for Transplantation." Cell Transplantation 31 (January 2022): 096368972211105. http://dx.doi.org/10.1177/09636897221110525.

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A growing need for organs and novel cell-based therapies has provided a niche for approaches like interspecies chimeras. To generate organs from one donor species in another host species requires techniques such as blastocyst complementation and gene editing to successfully create an embryo that has cells from both the donor and the host. However, the task of developing highly efficacious and competent interspecies chimeras is met by many challenges. These interspecies chimeric barriers impede the formation of chimeras, often leading to lower levels of chimeric competency. The barriers that ne
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Lacadena Calero, Juan Ramón. "BIOÉTIC AS MACAQUE-HUMAN CHIMERAS: SCIENTIFIC ASPECTS AND BIOETHICAL REFLECTIONS." Anales de la Real Academia Nacional de Farmacia, no. 87(02) (2021): 117–21. http://dx.doi.org/10.53519/anaesranf.2021.87.02.01.

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The obtention by Izpisua and collaborators (2021) of macaque-human chimeric embryos by microinjection of human pluripotent stem cells into early blastocysts of cynomolgus monkey is described. They studied the competency of human pluripotent stem cells in macaque embryos cultured ex vivo until 19 days post-fertilization. A reflection on these experiments is made from the bioethical point of view.
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Afanassieff, Marielle, Florence Perold, Wilhelm Bouchereau, Antoine Cadiou, and Nathalie Beaujean. "Embryo-derived and induced pluripotent stem cells: Towards naive pluripotency and chimeric competency in rabbits." Experimental Cell Research 389, no. 2 (2020): 111908. http://dx.doi.org/10.1016/j.yexcr.2020.111908.

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Hirabayashi, M., T. Goto, C. Tamura, M. Sanbo, and S. Hochi. "202 EFFECT OF LEUKEMIA INHIBITORY FACTOR AND FORSKOLIN ON ESTABLISHMENT OF RAT EMBRYONIC STEM CELL LINES." Reproduction, Fertility and Development 26, no. 1 (2014): 215. http://dx.doi.org/10.1071/rdv26n1ab202.

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Rat embryonic stem (ES) cell lines can be established in culture medium containing inhibitors for glycogen synthase kinase 3 (GSK3) and mitogen-activated protein kinase (MEK). We confirmed reproducibility of the 2i culture system in establishing rat ES cell lines (Hirabayashi et al. 2010 Mol. Reprod. Dev. 77, 94) and the likelihood of successful germline transmission (genuine) of rat ES cell lines established in leukemia inhibitory factor (LIF)- and forskolin (FK)-supplemented 2i medium (Hirabayashi et al. 2013 Transgenic Res. 22, 411–416). This study was designed to investigate whether LIF an
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Tapponnier, Yann, Marielle Afanassieff, Irène Aksoy, et al. "Reprogramming of rabbit induced pluripotent stem cells toward epiblast and chimeric competency using Krüppel-like factors." Stem Cell Research 24 (October 2017): 106–17. http://dx.doi.org/10.1016/j.scr.2017.09.001.

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Whitaker, Neal, Trista M. Berry, Nathan Rosenthal, et al. "Chimeric Coupling Proteins Mediate Transfer of Heterologous Type IV Effectors through the Escherichia coli pKM101-Encoded Conjugation Machine." Journal of Bacteriology 198, no. 19 (2016): 2701–18. http://dx.doi.org/10.1128/jb.00378-16.

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ABSTRACTBacterial type IV secretion systems (T4SSs) are composed of two major subfamilies, conjugation machines dedicated to DNA transfer and effector translocators for protein transfer. We show here that theEscherichia colipKM101-encoded conjugation system, coupled with chimeric substrate receptors, can be repurposed for transfer of heterologous effector proteins. The chimeric receptors were composed of the N-terminal transmembrane domain of pKM101-encoded TraJ fused to soluble domains of VirD4 homologs functioning inAgrobacterium tumefaciens,Anaplasma phagocytophilum, orWolbachia pipientis.
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Kondoh, Gen, Yoichi Yamamoto, Kayo Yoshida, et al. "Easy assessment of ES cell clone potency for chimeric development and germ-line competency by an optimized aggregation method." Journal of Biochemical and Biophysical Methods 39, no. 3 (1999): 137–42. http://dx.doi.org/10.1016/s0165-022x(99)00008-1.

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Fields, Chris, and Michael Levin. "Competency in Navigating Arbitrary Spaces as an Invariant for Analyzing Cognition in Diverse Embodiments." Entropy 24, no. 6 (2022): 819. http://dx.doi.org/10.3390/e24060819.

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One of the most salient features of life is its capacity to handle novelty and namely to thrive and adapt to new circumstances and changes in both the environment and internal components. An understanding of this capacity is central to several fields: the evolution of form and function, the design of effective strategies for biomedicine, and the creation of novel life forms via chimeric and bioengineering technologies. Here, we review instructive examples of living organisms solving diverse problems and propose competent navigation in arbitrary spaces as an invariant for thinking about the sca
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Zaslavsky, Alexander, Mackenzie Adams, Sandra Wissmueller, et al. "Glypican-1 as a novel immunotherapeutic target in prostate cancer." Journal of Clinical Oncology 36, no. 6_suppl (2018): 174. http://dx.doi.org/10.1200/jco.2018.36.6_suppl.174.

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174 Background: New effective therapies for men with prostate cancer are desperately needed. Recently, cancer immunotherapy has emerged as an important new treatment strategy for prostate cancer and for castrate resistant prostate cancer (CRPC). Multiple studies have identified the heparan sulfate proteoglycan-1 Glypican 1 (GPC-1) as being overexpressed in different cancers, and also as being a possible marker of poor prognosis in several solid tumor cancers. GPC-1 has been recently identified as a potential marker for prostate cancer. The MIL-38 monoclonal antibody detects GPC-1 and an IgG1 c
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Ugale, Amol Sanjay, Gudmundur Logi Norddahl, Martin Wahlestedt, et al. "Hematopoietic Stem Cells Are Intrinsically Protected Against MLL-ENL Mediated Transformation." Blood 124, no. 21 (2014): 839. http://dx.doi.org/10.1182/blood.v124.21.839.839.

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Abstract Studies on the developmental pathways of hematopoietic stem cells (HSCs) have led to roadmaps of differentiation and resulted in key information concerning lineage relationships and restriction points in the blood system. This knowledge is also central to understand the etiology of acute myeloid leukemia (AML), where recent work has proposed that the heterogeneity and aggressiveness of AML can associate with the developmental stage of transformation. Balanced chromosomal translocations that result in fusion proteins with aberrant transcriptional regulatory activities are frequent init
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Dissertations / Theses on the topic "Chimeric competency"

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Pijoff, Yannicke. "Colonisation embryonnaire et compétence chimérique des cellules souches pluripotentes : étude chez la souris, le lapin et le chimpanzé." Electronic Thesis or Diss., Lyon 1, 2024. http://www.theses.fr/2024LYO10255.

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Les cellules souches pluripotentes (PSC) naïves ont la capacité de réintégrer le développement embryonnaire normal et de produire des fœtus chimériques chez les rongeurs. Cependant, les PSC naïves provenant d'espèces autres que les rongeurs présentent une capacité nettement moins efficace à coloniser les embryons. Actuellement, notre compréhension des mécanismes impliqués dans la formation des chimères est limitée. Le projet avait pour objectif de mieux comprendre les mécanismes impliqués dans la capacité des PSC à coloniser l’embryon pré-implantatoire. Dans un premier temps, nous nous sommes
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Mutungi, Evans Mulandi. "Humoral immune responses against novel recombinant replication-competent poxvirus candidate vaccines expressing full length and chimeric lyssavirus glycoprotein genes." Diss., University of Pretoria, 2011. http://hdl.handle.net/2263/31290.

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Rabies is a neurological disease caused by viruses of the genus Lyssavirus belonging to the family Rhabdoviridae and order Mononegavirales. The Lyssavirus genus consists of eleven species namely rabies virus; Lagos bat virus; Mokola virus , Duvenhage virus; European bat lyssavirus virus type 1; European bat lyssavirus type 2; Australian bat lyssavirus; Aravan; Khujand; Irkut; West Caucasian bat viruses and recently isolated Shimoni bat virus. The prototype virus of the Lyssavirus genus is represented by rabies virus. The remaining lyssaviruses are collectively denoted as rabies-related viruses
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Books on the topic "Chimeric competency"

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Friedman, Jeffrey. Power without Knowledge. Oxford University Press, 2019. http://dx.doi.org/10.1093/oso/9780190877170.001.0001.

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Technocrats claim to know how to solve the social and economic problems of complex modern societies. But this would require predicting how people will act once technocrats impose their policy solutions. Power Without Knowledge argues that people’s ideas, w hich govern their deliberate actions, are too heterogeneous for their behavior to be reliably predicted. Thus, a technocracy of social-scientific experts cannot be expected to accomplish its objectives. The author also shows that a large part of contemporary mass politics, even populist mass politics, is technocratic, as members of the gener
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Book chapters on the topic "Chimeric competency"

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McGrath, Eoin, and Petr Machalik. "The Regulatory Framework for CAR-T Cells in Europe: Current Status and Foreseeable Changes AND Centre Qualification by Competent Authorities and Manufacturers." In The EBMT/EHA CAR-T Cell Handbook. Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-94353-0_37.

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AbstractUnder current European Union regulations, CAR-T cell therapies fall under the advanced therapy medicinal products (ATMPs) framework. ATMPs represent a category of medicinal products defined in EU Regulation 1394/2007 and subdivided into four categories, of which autologous or allogeneic CAR-T cells, among other therapies, are considered gene therapy medicinal products (GTMPs). ATMPs are subject to a centralized evaluation framework whereby one authorization is valid for all countries in the EU led by the European Medicines Agency’s Committee for Advanced Therapies (CAT). The framework
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Torres, Raul M., and Ralf Kühn. "ES cells - handling and use." In Laboratory Protocols for Conditional Gene Targeting. Oxford University PressOxford, 1997. http://dx.doi.org/10.1093/oso/9780199636778.003.0014.

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Abstract Pluripotent embryonic cells (ES cells) were first established directly from murine blastocysts in 1981 (136, 137) after unsuccessful early attempts to obtain germline chimerism with teratocarcinoma (EC) cells (138, 139 for review), and later shown to efficiently produce germline chimeras (140) even after transfection (141, 142). Since then, a fairly large number of ES cell lines have been generated and the lines currently often used for gene targeting experiments include D3 (143), E14 (144, 145), ABl (146), Rl (147), Jl (148) and CCE (140) which are all derived from 129 substrains or
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Eriksen, Andreas, and Michelle Everson. "Health Policy." In EU Regulatory Responses to Crises. Oxford University PressOxford, 2025. https://doi.org/10.1093/9780198913825.003.0004.

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Abstract This chapter uses the COVID-19 crisis as a magnifying glass to uncover the dynamics of integration in the field of health. The pandemic was met with a stretching of competences along with informal tactics that illustrate how narrow formal confines call for creative workarounds. While crisis management may legitimately call for creativity, informality, and flexibility, this chapter asks whether a more fundamental instability was brought to the fore. The Treaties suggest that the European Union (EU) can deal with regulatory issues concerned with public health, while redistributive issue
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Boomsma, Jacobus J. "The multicellular organisms and colonial superorganisms." In Domains and Major Transitions of Social Evolution. Oxford University PressOxford, 2022. http://dx.doi.org/10.1093/oso/9780198746171.003.0006.

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Abstract Comparative data indicate that clades of differentiated multicellular organisms and colonial superorganisms always originated by somatic adherence to a diploid (zygotic) cell and by comparable loyalty of a worker caste to monogamous parents. However, the functional analogy remains ambiguous because multicellular animals ultimately die from somatic failure while single-queen colonies die from germline failure. This difference relates to the forms of corruption that plague the two levels of organizational complexity, metazoan cancers due to somatic mosaicicm and inquiline social parasit
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Reports on the topic "Chimeric competency"

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Dolja, Valerian V., Amit Gal-On, and Victor Gaba. Suppression of Potyvirus Infection by a Closterovirus Protein. United States Department of Agriculture, 2002. http://dx.doi.org/10.32747/2002.7580682.bard.

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The plant virus family Polyviridae is the largest and most destructive of all plant viruses. Despite the continuous effort to develop resistant plant varieties, there is a desperate need for novel approaches conferring wide-range potyvirus resistance. Based on experiments with the tobacco etch potyvirus (TEV)-derived gene expression vector, we suggested approach for screening of the candidate resistance genes. This approach relies on insertion of the genes into a virus vector and evaluation of the phenotypes of the resulting recombinant viruses. The genes which suppress infection by the recomb
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Gurevitz, Michael, Michael E. Adams, Boaz Shaanan, et al. Interacting Domains of Anti-Insect Scorpion Toxins and their Sodium Channel Binding Sites: Structure, Cooperative Interactions with Agrochemicals, and Application. United States Department of Agriculture, 2001. http://dx.doi.org/10.32747/2001.7585190.bard.

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Integrated pest management in modern crop protection may combine chemical and biological insecticides, particularly due to the risks to the environment and livestock arising from the massive use of non-selective chemicals. Thus, there is a need for safer alternatives, which target insects more specifically. Scorpions produce anti-insect selective polypeptide toxins that are biodegradable and non-toxic to warm-blooded animals. Therefore, integration of these substances into insect pest control strategies is of major importance. Moreover, clarification of the molecular basis of this selectivity
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