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1

Wang, Mei-Hui. "Xiaolin: Un'esplorazione su barzellette e umorismo nella cultura cinese antica." Traduction et Langues 23, no. 2 (2024): 209–32. http://dx.doi.org/10.52919/translang.v23i2.1003.

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Xiaolin: An Exploration of Jokes and Humor in Ancient Chinese Culture This article is based on the study of the book "Xiaolin" (The Forest of Laughter) by Handan Chun 邯鄲淳 (ca.132-ca.221) of the Cao Wei 曹魏 period in the Eastern Han Dynasty 東漢 (25-220).The first book dedicated to jokes in ancient China. The realistic and satirical folk stories produced against the backdrop of the times, reflected the interest in life, humor and the educational sense of the literati, lower-class and common peopleof that period (Wang, 1981; Huang, 1999). Focusing on the only 29 jokes left in the book, the extracts
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2

Chen, Naifei, Chengfei Pu, Lingling Zhao, et al. "Abstract 1130: A phase 1 dose escalation study of GCC19CART - a novel CoupledCAR therapy for subjects with metastatic colorectal cancer." Cancer Research 83, no. 7_Supplement (2023): 1130. http://dx.doi.org/10.1158/1538-7445.am2023-1130.

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Abstract Background: Chimeric antigen receptor (CAR) T-cell therapy has shown remarkable clinical efficacy in hematologic malignancies but limited success in solid tumors. GCC19CART, the first clinical candidate from the CoupledCAR solid tumor platform, is designed to overcome the limitations of conventional CAR T-cells in solid tumor malignancies by pairing solid tumor CAR T-cells with CD19 targeting CAR T-cells to amplify proliferation and activation of the solid tumor CAR T component. GCC19CART targets guanylate cyclase-C (GCC) which is expressed in the metastatic lesions of 70%-80% of subj
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Shen, Hongling, Xiaofeng Xu, Hongfei Rong, et al. "Abstract 501: Discovery of BPI-460372, a potent and selective inhibitor of TEAD for the treatment of solid tumors harboring Hippo pathway aberrations." Cancer Research 83, no. 7_Supplement (2023): 501. http://dx.doi.org/10.1158/1538-7445.am2023-501.

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Abstract The Hippo signaling pathway is critical for the regulation of organ development, tissue homeostasis, and tumorigenesis by controlling the activation status of yes-associated protein (YAP) or its homolog PDZ-binding motif (TAZ). As a major downstream effector, the transcription factor TEAD is activated by forming a complex with YAP/TAZ. Hippo pathway aberrations, such as NF2-deficiency or LATS1/2 mutations leading to hyperactivation of YAP/TAZ and subsequent activation of TEAD, have been reported in many cancers, including mesothelioma, meningioma, soft tissue sarcoma and non-small cel
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Lu, Si, Yu Chen, Meiyu Fang, et al. "Abstract CT208: Tebotelimab, a PD-1/LAG-3 bispecific antibody, in patients with untreated, unresectable, recurrent or metastatic, mucosal melanoma: An open-label, single-arm, Phase 1 study." Cancer Research 83, no. 8_Supplement (2023): CT208. http://dx.doi.org/10.1158/1538-7445.am2023-ct208.

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Abstract Background: Immune checkpoint inhibitors (CPIs) targeting PD-(L)1 have become a standard of care for untreated, advanced melanoma, but demonstrated limited efficacy in mucosal melanoma. Tebotelimab, also known as MGD013, is a PD-1/LAG-3 bispecific tetravalent DART® molecule with synergistic antitumor activity shown in preclinical studies. We conducted an open-label, single-arm, multi-cohort phase 1 study (NCT04653038) to assess the efficacy and safety of tebotelimab in melanoma patients (pts) including those with CPI-naïve mucosal melanoma. Methods: The CPI-naïve cohort of this study
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Liu, Yarong, Jingwei Sun, Yao Sheng, et al. "Abstract 4062: The discovery and development of a CRISPR/Cas9-engineered tumor-infiltrating lymphocytes product (GT316) as a next-generation TIL therapy." Cancer Research 83, no. 7_Supplement (2023): 4062. http://dx.doi.org/10.1158/1538-7445.am2023-4062.

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Abstract Adoptive cell therapy by tumor-infiltrating lymphocytes (TILs) has demonstrated promising therapeutic effects in multiple types of solid tumors and significantly prolonged the survival of late-stage patients. However, the “prone-to-exhaustion” phenotype of the final TIL product after rapid expansion during manufacture and the presence of various immunosuppressive mechanisms in tumor microenvironment (TME) compromises the persistence and anti-tumor efficacy of TIL post infusion. To discover potential immunoregulatory targets that could maximize the function of TIL, we established a gen
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Abass, Athraa A., Radhwan Alhashem, and Ghazwan Alhashem. "A cross-sectional study on the symptoms of depression in dental students in Kerbela." Technium BioChemMed 11 (November 29, 2024): 16–22. http://dx.doi.org/10.47577/biochemmed.v11i.12117.

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Doktorchik C, Patten S, Eastwood C, et al. Validation of a case definition for depression in administrative data against primary chart data as a reference standard. BMC Psychiatry. 2019;19(1):9. doi:10.1186/s12888-018-1990-6 Mancuso E, Sampogna G, Boiano A, Della Rocca B, Di Vincenzo M, Lapadula MV, Martinelli F, Lucci F, Luciano M. Biological correlates of treatment resistant depression: a review of peripheral biomarkers. Front Psychiatry. 2023 Oct 24; 14:1291176. doi: 10.3389/fpsyt.2023.1291176. PMID: 37941970; PMCID: PMC10628469. Machado MO, Veronese N, Sanches M, et al. The association of
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7

Frentzas, Sophia, Haesong Park, George Budd, et al. "Abstract PO1-04-01: Phase 1 dose escalation study of ARX788, a next-generation anti-HER2 antibody drug conjugate, in heavily pretreated breast cancer patients." Cancer Research 84, no. 9_Supplement (2024): PO1–04–01—PO1–04–01. http://dx.doi.org/10.1158/1538-7445.sabcs23-po1-04-01.

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Abstract Introduction: ARX788 is a next-generation anti-HER2 antibody-drug conjugate (ADC) conjugated to amberstatin269 (AS269), a potent cytotoxic tubulin inhibitor. ARX788 is highly stable with nearly identical PK profiles for the total ADC and the total antibody due to proprietary site-specific oxime conjugation chemistry. The stability of ARX788 results in limited systemic toxicity and increased targeted delivery of payload to tumor cells. Clinical benefit of ARX788 has been observed in patients (pts) with HER2-positive (HER2-pos) breast cancer (BC) in multiple clinical trials and recently
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8

Warmansyah, Jhoni, Elis Komalasari, Eliza Febriani, Gusmiati, and Amalina. "Factors Affecting Teacher Readiness for Online Learning (TROL) in Early Childhood Education: TISE and TPACK." JPUD - Jurnal Pendidikan Usia Dini 16, no. 1 (2022): 32–51. http://dx.doi.org/10.21009/jpud.161.03.

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This study aims to find empirical information about the effect of Technological Pedagogical Content Knowledge (TPACK), and Technology Integration Self Efficacy (TISE) on Teacher Readiness for Online Learning (TROL). This study uses a quantitative survey method with path analysis techniques. This study measures the readiness of kindergarten teachers in distance learning in Tanah Datar Regency, West Sumatra Province, Indonesia with a sampling technique using simple random sampling involving 105 teachers. Empirical findings reveal that; 1) there is a direct positive effect of Technology Integrati
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9

Notícias, Transfer. "Noticias." Transfer 11, no. 1-2 (2021): 309–20. http://dx.doi.org/10.1344/transfer.2016.11.309-320.

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NOTICIAS / NEWS (“Transfer”, 2016) 1) CONGRESOS / CONFERENCES: 1. Languages & the Media – Agile Mediascapes: Personalising the Future, Hotel Radisson Blu, Berlín, 2-4 Nov. 2016 www.languages-media.com 2. Third Chinese Drama Translation Colloquium Newcastle University, UK, 28-19 Junio 2016. www.ncl.ac.uk/sml/about/events/item/drama-translation-colloquium 3. 16th Annual Portsmouth Translation Conference – Translation & Interpreting: Learning beyond the Comfort Zone, University of Portsmouth, UK, 5 Nov. 2016. www.port.ac.uk/translation/events/conference 4. 3rd International Conference on
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Amin, Adam Aliathun, and Eva Imania Eliasa. "Parenting Skills as The Closest Teacher to Early Childhood at Home." JPUD - Jurnal Pendidikan Usia Dini 17, no. 2 (2023): 312–30. http://dx.doi.org/10.21009/jpud.172.09.

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Parents play an important role in the development of their children. This research reflects the role of parents in developing children. Through four stages of identification, screening, eligibility, and acceptable results, this method uses a systematic literature review using the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-analyses) method. The findings from the fourteen articles examined show that parenting skills play an important role in a child's growth and development from birth to death. The determining factor in the development of physical, motoric, moral, language
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11

RBDINF. "RBINF - Coleção (jun. 2012/jun. 2020)." July 24, 2020. https://doi.org/10.5281/zenodo.5893340.

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Revista Brasileira de Infraestrutura - RBINF | 01 v. 1 n. 01 (2012) Revista Completa (PDF) Apresenta&ccedil;&atilde;o <strong>Doutrina |&nbsp;</strong><strong>Artigos</strong> Nuevas formas de relacionamiento p&uacute;blico-privado en el cumplimiento de los cometidos del Estado&nbsp;| Augusto Dur&aacute;n Mart&iacute;nez Nuevas perspectivas para la financiaci&oacute;n de obras p&uacute;blicas locales en el derecho espa&ntilde;ol&nbsp;| Jaime Rodr&iacute;guez-Arana Mu&ntilde;oz, Jorge Buj&aacute;n Regula&ccedil;&atilde;o sustent&aacute;vel de infraestruturas&nbsp;| Thiago Marrara Notas sobre o
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12

Van Dem, Pham, Pham Trung Kien, Nguyen Thanh Trung, et al. "Clinical, Paraclinical Characteristics and Relative Risk Factors of Severe Degree in Children with COVID-19: Systematic Review." VNU Journal of Science: Medical and Pharmaceutical Sciences 38, no. 1 (2022). http://dx.doi.org/10.25073/2588-1132/vnumps.4371.

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Aim: systematic review of studies in the medical literature of children with COVID – 19 in order to provide evidence of clinical, paraclinical characteristics and relative risk factors of severe degree in children with COVID-19. Research subjects: A systematic review of studies on COVID-19 in children published in the international medical literature. Research methods: the information of research reports was selected from information posted on the COVID-19 update reporting portal of the Ministry of Health, PubMed, EMBASE, Cochrane Library, WHO COVID-19 Database, China National Knowledge Infras
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13

Thanh Huyen, Le, Dao Sy Duc, Nguyen Xuan Hoan, Nguyen Huu Tho, and Nguyen Xuan Viet. "Synthesis of Fe3O4-Reduced Graphene Oxide Modified Tissue-Paper and Application in the Treatment of Methylene Blue." VNU Journal of Science: Natural Sciences and Technology 35, no. 3 (2019). http://dx.doi.org/10.25073/2588-1140/vnunst.4883.

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Graphene-based composites have received a great deal of attention in recent year because the presence of graphene can enhance the conductivity, strength of bulk materials and help create composites with superior qualities. Moreover, the incorporation of metal oxide nanoparticles such as Fe3O4 can improve the catalytic efficiency of composite material. In this work, we have synthesized a composite material with the combination of reduced graphene oxide (rGO), and Fe3O4 modified tissue-paper (mGO-PP) via a simple hydrothermal method, which improved the removal efficiency of the of methylene blue
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14

Trindade, Jonas Faviero. "O DIREITO ADMINISTRATIVO NA ERA DA REPRODUTIBILIDADE TÉCNICA: DOS PRECEDENTES, DAS SÚMULAS E DOS ENUNCIADOS DE TESES." October 15, 2021. https://doi.org/10.5281/zenodo.5571387.

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O DIREITO ADMINISTRATIVO NA ERA DA REPRODUTIBILIDADE T&Eacute;CNICA: DOS PRECEDENTES, DAS S&Uacute;MULAS E DOS ENUNCIADOS DE TESES Jonas Faviero Trindade Palavras-chave:&nbsp; Direito Administrativo, Interpreta&ccedil;&atilde;o construtiva, Literatura, Precedentes, Reprodutibilidade Resumo Em um pa&iacute;s de tradi&ccedil;&atilde;o&nbsp;<em>civil law</em>, como o Brasil, h&aacute; uma crescente valoriza&ccedil;&atilde;o dos precedentes, assim como de suas manifesta&ccedil;&otilde;es adjacentes, como os enunciados de s&uacute;mulas e de teses. O fen&ocirc;meno atinge diretamente o Direito Admi
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15

Chen, Jasmine Yu-Hsing. "Beyond Words." M/C Journal 27, no. 2 (2024). http://dx.doi.org/10.5204/mcj.3033.

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Introduction Despite the expansive and multimodal realm of Chinese Boys’ Love (BL) culture (also known as danmei in Chinese), audio works have been notably absent from scholarly discussions, with the focus predominantly being on novels (e.g. Bai; Zhang). This article aims to fill this gap by delving into the transformative impact of sound on narrative engagement within the Chinese BL culture. Focussing on the audio drama adaptations of Grandmaster of Demonic Cultivation (modao zushi, hereafter Grandmaster), originally a serialised Chinese BL novel, this analysis aims to unravel the meticulousl
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16

Kojo, Kosuke, Tomoko Oguri, Takazo Tanaka, et al. "Seminal plasma metallomics: a new horizon for diagnosing and managing male infertility." Revista Internacional de Andrología 23, Published Ahead of Print (2025). https://doi.org/10.22514/j.androl.2025.013.

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The authors, Kosuke Kojo and Tomoko Oguri, contributed equally. This HTML edition is publicly accessible at the following URL:https://academic298uro.github.io/open-archive/2025/seminal-plasma-metallomics-new-horizon/ Abstract Seminal plasma contains a wide range of biomolecules&mdash;including inorganic elements&mdash;that may significantly influence male reproductive function. Historically, semen analysis has focused on sperm count and motility, while overlooking the diagnostic potential of this acellular fraction. This narrative review synthesizes historical perspectives on seminal plasma me
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Nielsen, Hanne E. F., Chloe Lucas, and Elizabeth Leane. "Rethinking Tasmania’s Regionality from an Antarctic Perspective: Flipping the Map." M/C Journal 22, no. 3 (2019). http://dx.doi.org/10.5204/mcj.1528.

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IntroductionTasmania hangs from the map of Australia like a drop in freefall from the substance of the mainland. Often the whole state is mislaid from Australian maps and logos (Reddit). Tasmania has, at least since federation, been considered peripheral—a region seen as isolated, a ‘problem’ economically, politically, and culturally. However, Tasmania not only cleaves to the ‘north island’ of Australia but is also subject to the gravitational pull of an even greater land mass—Antarctica. In this article, we upturn the political conventions of map-making that place both Antarctica and Tasmania
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