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Dissertations / Theses on the topic 'Chiral drugs Chromatographic analysis'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Layton, Sherry E. "Comparison of various chiral stationary phases for the chromatographic separation of chiral pharmaceuticals /." Electronic version (PDF), 2005. http://dl.uncw.edu/etd/2005/laytons/sherrylayton.pdf.

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2

Watt, Alan Paul. "Liquid chromatographic and mass spectrometric methods for the chiral analysis of drugs and drug metabolites." Thesis, University of Hertfordshire, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.421286.

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3

Crabb, Nicholas Clive. "Applications of chiral chromatography to the analysis of drugs and herbicides." Thesis, University of Bradford, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.277117.

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4

Mertzman, Melissa Danielle Foley Joe Preston. "Chiral microemulsion electrokinetic chromatography /." Philadelphia, Pa. : Drexel University, 2004. http://dspace.library.drexel.edu/handle/1860/340.

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5

Kahle, Kimberly Ann Foley Joe Preston. "Effect of identity and number of chiral microemulsion components in chiral microemulsion electrokinetic chromatography /." Philadelphia, Pa. : Drexel University, 2007. http://hdl.handle.net/1860/1293.

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6

Hider, Gregg C. "High-performance liquid chromatographic analysis of commonly used drugs /." Online version of thesis, 1988. http://hdl.handle.net/1850/10693.

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Thesis (M.S.)--Rochester Institute of Technology, 1988.<br>Includes Addendum: High-performance liquid chromatographic analysis of commonly used drugs: Six laboratory experiments for clinical chemistry students. Includes bibliographical references (leaves 48-52).

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7

Carlsson, Björn. "From achiral to chiral analysis of citalopram /." Linköping : Univ, 2003. http://www.ep.liu.se/diss/med/07/93/index.html.

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8

Song, Shin Miin, and shinmiin@singnet com sg. "Comprehensive two-dimensional gas chromatography (GCxGC ) for drug analysis." RMIT University. Applied Sciences, 2006. http://adt.lib.rmit.edu.au/adt/public/adt-VIT20080627.114511.

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Separation technologies have occupied a central role in the current practices of analytical methods used for drug analysis today. As the emphasis in contemporary drug analysis shifts towards ultra-trace concentrations, the contribution from unwanted matrix interferences takes on greater significance. In order to single out a trace substance with confidence from a rapidly expanding list of drug compounds (and their metabolites) in real complex specimens, analytical technologies must evolve to keep up with such trends. Today, the task of unambiguous identification in forensic toxicology still re

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9

Modzabi, Selorm Kwame Busch Kenneth W. Busch Marianna A. "Studies on new approaches of chiral discrimination for chiral analysis by regression modeling of spectral data." Waco, Tex. : Baylor University, 2009. http://hdl.handle.net/2104/5349.

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10

Carlsson, Björn. "From achiral to chiral analysis of citalopram." Doctoral thesis, Linköpings universitet, Klinisk farmakologi, 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-5217.

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Within the field of depression the “monoamine hypothesis” has been the leading theory to explain the biological basis of depression. This theory proposes that the biological basis of depression is due to a deficiency in one or more of three key neurotransmitter systems, namely noradrenaline, dopamine and serotonin which are thought to mediate the therapeutic actions of virtually every known antidepressant agent. Citalopram is a selective serotonin-reuptake inhibitor (SSRI) used for the treatment of depression and anxiety disorders. Citalopram is a racemic compound, in other words composed of a

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11

Reilly, John. "A comparison of electrophoretic and chromatographic separation techniques for the determination of chiral and achiral impurities." Thesis, Imperial College London, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.270880.

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12

Stauffer, Scott T. "Expert system shells in chemistry : CHIRULE, a chiral chromatographic column selection system using similarity searching and personal construct theory /." Diss., This resource online, 1993. http://scholar.lib.vt.edu/theses/available/etd-10042006-143845/.

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Thesis (Ph. D.)--Virginia Polytechnic Institute and State University, 1993.<br>Vita. Abstract. Vol. 2 is appendices. Includes bibliographical references (leaves 327-337). Also available via the Internet.

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13

Noctor, T. A. G. "Chiral separation of drugs and related compounds by high-performance liquid chromatography : Evaluation of enantioselective high-performance liquid chromatographic techniques and their application to drugs, metabolites and related compounds." Thesis, University of Bradford, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.233673.

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14

Morrison, Calum M. "Chiral and achiral analysis of benzodiazepine and anti-anginal drugs in forensic toxicology." Thesis, University of Glasgow, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.321443.

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15

Malm, Mikaela. "Drug Analysis : Bioanalytical Method Development and Validation." Doctoral thesis, Uppsala universitet, Analytisk kemi, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8547.

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This thesis describes bioanalytical methods for drug determination in biological matrixes, with drugs in focus used against diseases largely affecting low-income countries. Solid-phase extraction is used for sample cleanup, and processed samples are analyzed by liquid chromatography. Developed bioanalytical methods are validated according to international guidelines. Eflornithine (DFMO) is a chiral drug, used for treating human African trypanosomiasis. A bioanalytical method for determination of DFMO enantiomers in plasma is presented. The enantiomers are detected by evaporative light-scatteri

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16

Fowlis, I. A. "Studies of chromatographic and spectroscopic methods for the analysis of anabolic steroids and other drugs." Thesis, Swansea University, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.636999.

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The objectives of these studies were to develop multidimensional chromatographic techniques and combine them, in some cases with mass spectrometry, in order to provide improved methods for the determination of an anabolic steroid in plasma extracts and for the identification of by-products in drug process waste streams and bulk products. Combination of high pressure liquid chromatography (HPLC) with high resolution capillary gas chromatography (HRGG) was studied using an autosampler as an interface device. Detailed investigations were carried out using liquid chromatography solute preconcentra

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17

McGrath, Gareth. "The determination of selected drugs and endogenous molecules by modern electrophoretic, chromatographic and voltammetric techniques." Thesis, University of Ulster, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.241755.

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18

Yeung, Kai Tai. "Molecular simulations of the enantioseparating mechanism of polysaccharide-based chiral stationary phase and enzymatic acylation of N-benzoyl-L-arginine ethyl ester in binary aquo-organic solvent mixtures." HKBU Institutional Repository, 2007. http://repository.hkbu.edu.hk/etd_ra/819.

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19

Khundker, Sharmin. "Theory of solvation and its application to the supercritical fluid extraction/supercritical fluid chromatographic analysis of pharmaceuticals." Thesis, Northumbria University, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.245283.

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The roam objectives of this PhD project were to relate anal~ te solubility in supercritical carbon dioxide via molecular structure and also to investigate the factors that influence the solubility and extraction of analytes in a supercritical fluid extraction (SFE) when using carbon dioxide as the solvent. The polarity of an analyte was selected as the key parameter to developing a means of estimating steroid solubility in supercritical carbon dioxide. Polarity can be estimated by the hydrophobicity term, log P (based on partition coefficients), and also of the solubility parameter, 0,. The us

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20

Marchant, Carol A. "NMR studies of the cyclodextrin complexes of some 2-arylpropionates and their application to chiral analysis." Thesis, University of Bath, 1992. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.303408.

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21

Mitheo, Yannick K. "Determination of Solute Descriptors for Illicit Drugs Using Gas Chromatographic Retention Data and Abraham Solvation Model." Thesis, University of North Texas, 2015. https://digital.library.unt.edu/ark:/67531/metadc804935/.

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In this experiment, more than one hundred volatile organic compounds were analyzed with the gas chromatograph. Six capillary columns ZB wax plus, ZB 35, TR1MS, TR5, TG5MS and TG1301MS with different polarities have been used for separation of compounds and illicit drugs. The Abraham solvation model has five solute descriptors. The solute descriptors are E, S, A, B, L (or V). Based on the six stationary phases, six equations were constructed as a training set for each of the six columns. The six equations served to calculate the solute descriptors for a set of illicit drugs. Drugs studied are

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22

Aldlgan, Abdulaziz. "Chromatographic analysis and survey studies to evaluate the emerging drugs of synthetic cannabinoids in Scotland and Saudi Arabia." Thesis, University of Glasgow, 2016. http://theses.gla.ac.uk/7579/.

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Synthetic cannabinoid receptor agonists or more commonly known as synthetic cannabinoids (SCs) were originally created to obtain the medicinal value of THC but they are an emerging social problem. SCs are mostly produced coated on herbal materials or in powder form and marketed under a variety of brand names, e.g. “Spice”, “K2”. Despite many SCs becoming controlled under drug legislation, many of them remain legal in some countries around the world. In Scotland, SCs are controlled under the Misuse of Drugs Act 1971 and Psychoactive Substances Act 2016 that only cover a few early SCs. In Saudi

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23

Nickum, Elisa A. "Analysis of Regulated Drugs Using Chromatographic and Spectrophotometric Techniques Coupled with Spectroscopy An Orthogonal Approach to Protecting Public Health." University of Cincinnati / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1504799568245931.

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24

Zu, Chengli. "Enantiomer analysis using electrospray ionization mass spectrometry." Diss., Mississippi State : Mississippi State University, 2007. http://library.msstate.edu/etd/show.asp?etd=etd-04092007-103342.

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25

Dogra, Jody A. Busch Kenneth W. Busch Marianna A. "Multivariate analyses of near-infrared and UV spectral data." Waco, Tex. : Baylor University, 2009. http://hdl.handle.net/2104/5347.

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26

Arnell, Robert. "Development and Validation of Methods for Characterization of Multi-Component Systems in Preparative LC." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7422.

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27

Mandimika, Nyaradzo. "Evaluation of the pharmaceutical availability of erythromycin from topical formulations." Thesis, Rhodes University, 2008. http://eprints.ru.ac.za/1176/.

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28

Nascimento, Andréia Peraro do. "Desenvolvimento e validação de metodologia para medicamentos contendo dipirona sódica e cloridrato de papaverina isolados e em associação." Universidade de São Paulo, 2006. http://www.teses.usp.br/teses/disponiveis/9/9139/tde-01082012-162353/.

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A dipirona sódica em associação com o cloridrato de papaverina é usada como medicamento analgésico e antiespasmódico. O objetivo desta pesquisa foi o desenvolvimento e validação de métodos analíticos para a determinação de dipirona sódica e cloridrato de papaverina em preparações farmacêuticas. A solução oral contendo dipirona sódica isolada e a solução oral contendo a associação de dipirona sódica e cloridrato de papaverina foram determinadas por cromatografia líquida de alta eficiência, com as condições padronizadas: Coluna cromatográfica: Supelcosil C18 - LCPH (250 mm X 4,6 mm, 5µm) Su

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29

He, Ying-Hong, and 何盈宏. "Titanium dioxide headspace in-needle solid-phase microextraction gas chromatographic- mass spectrometry for chiral amphetamine-like abuse drugs analysis." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/62100495163880171443.

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30

Khulu, Sinegugu. "Interaction studies of chiral non-steroidal anti-inflammatory drugs with HSA protein using capillary electrophoresis frontal analysis and electrokinetic chromatography." Thesis, 2015. http://hdl.handle.net/10321/1270.

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Submitted in fulfillment of the requirements of the degree of Master of Applied Science in Chemistry, Durban University of Technology, 2015.<br>Human Serum Albumin (HSA) predominantly found in the blood plasma proteins, acts as a carrier for many drugs. In the present work binding interactions of eight arylpropionate non-steroidal anti-inflammatory drugs (NSAIDs) were studied with Human Serum Albumin HSA using Capillary Electrophoresis (CE) under physiological conditions. The concentration of HSA was kept constant (525 μM) whereas the drug concentrations were varied between 50-300 μM in each c

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31

Sun, Ping. "Development of new chiral selectors for liquid chromatography and their performance relative to established chiral stationary phases (CSPS)." 2009. http://hdl.handle.net/10106/2031.

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32

Wang, Chunlei. "Enantiomeric separations and new chiral stationary phases." 2009. http://hdl.handle.net/10106/2038.

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33

Joseph, Kathryn (Krina) S. "Chromatographic studies of drug-protein binding in diabetes." 2010. http://proquest.umi.com/pqdweb?did=2020751081&sid=7&Fmt=2&clientId=14215&RQT=309&VName=PQD.

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Thesis (Ph.D.)--University of Nebraska-Lincoln, 2010.<br>Title from title screen (site viewed July 8, 2010). PDF text: x, 259 p. : ill. (chiefly col.) ; 4 Mb. UMI publication number: AAT 3398195. Includes bibliographical references. Also available in microfilm and microfiche formats.

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34

Adamusová, Hana. "Využití vysokoúčinných separačních metod pro analýzy biologicky aktivních látek." Doctoral thesis, 2017. http://www.nusl.cz/ntk/nusl-369437.

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In the first part of this doctoral thesis, a new analytical HPLC-MS/MS method for monitoring of concentration changes of 17β-estradiol (βE2) during in vitro mouse sperm capacitation was developed. Capacitation was performed for three initial concentrations of βE2 (200, 20 and 2 μg/L). For all the concentrations a similar trend for the total unbound βE2 was observed. In general, the βE2 concentration decreased to reach its minimum and then increased again. The position of the minimum differed for the individual tested βE2 concentrations. Experimentally obtained results were subjected to the kin

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35

Ncube, Somandla. "Liquid phase microextraction of hallucinogenic compounds from human urine samples based on single hollow fibre followed by chromatographic determination." Thesis, 2016. http://hdl.handle.net/10539/21207.

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A dissertation submitted to the Faculty of Science, University of the Witwatersrand in fulfilment of the requirements for the degree of Master of Science. University of the Witwatersrand, Johannesburg, March 2016<br>A liquid phase microextraction based on single hollow fibre followed by liquid chromatographic determination was developed for the extraction and quantification of the hallucinogenic muscimol and its two precursors, tryptophan and tryptamine from urine samples. A multivariate design of experiment was used in which a half fractional factorial approach was applied to screen six

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36

Lin, Ming-Chun, and 林明君. "Fluorogenic Derivatization and Liquid Chromatographic Method for the Analysis of Organic Acid Drugs in Plasma and Pharmaceutical Preparations." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/83764348687025539521.

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博士<br>高雄醫學大學<br>藥學研究所博士班<br>93<br>Organic acids are widely found in biological and pharmaceutical samples. Many important organic acids are lack of chromophore in structure; therefore, they can not be directly analyzed at trace levels by absorption spectrophotometry. We have developed several methods for the sensitive analysis of bile acids, valproic acid, undecylenic acid and zinc undecylenate. The analytes were derivatized with 2-(2-naphthoxy)ethyl 2-(piperidino)ethanesulfonate (NOEPES) catalyzed by 18-crown-6 ether and potassium bicarbonate. The resulting derivatives were analyzed by isocra

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37

Bokretsion, Rahel Girmai. "On-line process control in pharmaceutical industry." Diss., 2003. http://hdl.handle.net/2263/27182.

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